GPR158

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03243779
2synaptic vesicle maturation (GO:0016188)5.63395571
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.58891724
4locomotory exploration behavior (GO:0035641)5.52212780
5synaptic vesicle exocytosis (GO:0016079)5.38246918
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30222029
7vocalization behavior (GO:0071625)5.27629975
8L-amino acid import (GO:0043092)5.16097478
9glutamate secretion (GO:0014047)5.06076890
10neuronal action potential propagation (GO:0019227)5.05700612
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05030290
12regulation of synaptic vesicle exocytosis (GO:2000300)4.99425314
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.91549367
14amino acid import (GO:0043090)4.79665555
15regulation of glutamate receptor signaling pathway (GO:1900449)4.71010765
16potassium ion homeostasis (GO:0055075)4.59652329
17neurotransmitter secretion (GO:0007269)4.50007093
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.45929967
19potassium ion import (GO:0010107)4.45485151
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43975060
21protein localization to synapse (GO:0035418)4.43256466
22regulation of synaptic vesicle transport (GO:1902803)4.42261507
23regulation of neuronal synaptic plasticity (GO:0048168)4.34006870
24regulation of synapse structural plasticity (GO:0051823)4.31055908
25neuron cell-cell adhesion (GO:0007158)4.27849919
26synaptic transmission, glutamatergic (GO:0035249)4.18689403
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17262132
28negative regulation of dendrite morphogenesis (GO:0050774)4.17007285
29neuron-neuron synaptic transmission (GO:0007270)4.15515129
30exploration behavior (GO:0035640)4.15187237
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14244436
32central nervous system myelination (GO:0022010)4.14183564
33axon ensheathment in central nervous system (GO:0032291)4.14183564
34neurotransmitter-gated ion channel clustering (GO:0072578)4.09067572
35glutamate receptor signaling pathway (GO:0007215)4.03217156
36cellular sodium ion homeostasis (GO:0006883)4.00363384
37gamma-aminobutyric acid transport (GO:0015812)3.93437266
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.92685490
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91625535
40positive regulation of membrane potential (GO:0045838)3.88146106
41neurotransmitter uptake (GO:0001504)3.85167457
42long-term memory (GO:0007616)3.84359619
43righting reflex (GO:0060013)3.84053448
44cellular potassium ion homeostasis (GO:0030007)3.77129058
45regulation of synapse maturation (GO:0090128)3.76078587
46cerebellar Purkinje cell differentiation (GO:0021702)3.73529803
47regulation of postsynaptic membrane potential (GO:0060078)3.72933565
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71361945
49prepulse inhibition (GO:0060134)3.71162946
50activation of protein kinase A activity (GO:0034199)3.65896230
51regulation of ARF protein signal transduction (GO:0032012)3.64562031
52neurotransmitter transport (GO:0006836)3.64036351
53layer formation in cerebral cortex (GO:0021819)3.62039820
54startle response (GO:0001964)3.58348992
55positive regulation of synapse maturation (GO:0090129)3.58057382
56regulation of synaptic plasticity (GO:0048167)3.56843994
57auditory behavior (GO:0031223)3.54230454
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.52622574
59transmission of nerve impulse (GO:0019226)3.52452587
60dendritic spine morphogenesis (GO:0060997)3.51511270
61cerebellar Purkinje cell layer development (GO:0021680)3.50938128
62neuromuscular process controlling posture (GO:0050884)3.48851521
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48563439
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.47784624
65long-term synaptic potentiation (GO:0060291)3.47724918
66neuromuscular process controlling balance (GO:0050885)3.47427176
67positive regulation of dendritic spine development (GO:0060999)3.45107691
68proline transport (GO:0015824)3.44105867
69behavioral response to cocaine (GO:0048148)3.43167410
70regulation of neurotransmitter levels (GO:0001505)3.42688436
71positive regulation of neurotransmitter transport (GO:0051590)3.38890390
72regulation of dendritic spine morphogenesis (GO:0061001)3.38593599
73regulation of neurotransmitter secretion (GO:0046928)3.38566421
74acidic amino acid transport (GO:0015800)3.36831588
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34476418
76sodium ion export (GO:0071436)3.34389306
77membrane depolarization during action potential (GO:0086010)3.33971017
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31885808
79positive regulation of neurotransmitter secretion (GO:0001956)3.31539792
80striatum development (GO:0021756)3.30482477
81response to auditory stimulus (GO:0010996)3.29529759
82positive regulation of synaptic transmission, GABAergic (GO:0032230)3.29104310
83membrane depolarization (GO:0051899)3.28093048
84membrane hyperpolarization (GO:0060081)3.26328356
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24651437
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24423096
87regulation of vesicle fusion (GO:0031338)3.22922807
88regulation of neurotransmitter transport (GO:0051588)3.22641970
89response to histamine (GO:0034776)3.22573060
90synaptic vesicle endocytosis (GO:0048488)3.21877205
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21644835
92regulation of dendritic spine development (GO:0060998)3.20370099
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19775531
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.19154089
95negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17582419
96detection of calcium ion (GO:0005513)3.14835120
97regulation of voltage-gated calcium channel activity (GO:1901385)3.10890480
98presynaptic membrane assembly (GO:0097105)3.09334071
99neuron recognition (GO:0008038)3.08470007
100cerebellar granule cell differentiation (GO:0021707)3.06999764
101cell differentiation in hindbrain (GO:0021533)3.06933425
102cell communication involved in cardiac conduction (GO:0086065)3.05547562
103chemosensory behavior (GO:0007635)3.04766636
104neuronal ion channel clustering (GO:0045161)3.04023049
105vesicle docking involved in exocytosis (GO:0006904)3.03926899
106adult walking behavior (GO:0007628)3.03814591
107negative regulation of dendrite development (GO:2000171)3.02558779
108synaptic transmission (GO:0007268)3.01436742
109synaptic vesicle transport (GO:0048489)3.01358600
110establishment of synaptic vesicle localization (GO:0097480)3.01358600
111mechanosensory behavior (GO:0007638)3.01328748
112postsynaptic membrane organization (GO:0001941)3.00617190
113mating behavior (GO:0007617)3.00445215
114vesicle transport along microtubule (GO:0047496)3.00428759
115positive regulation of synaptic transmission (GO:0050806)2.99936532
116learning (GO:0007612)2.99681478
117presynaptic membrane organization (GO:0097090)2.98784202
118neuromuscular process (GO:0050905)2.98594124
119synaptic transmission, dopaminergic (GO:0001963)2.96787120
120glycine transport (GO:0015816)2.96365447
121cell communication by electrical coupling (GO:0010644)2.96344914
122behavioral defense response (GO:0002209)2.96264134
123behavioral fear response (GO:0001662)2.96264134
124synapse assembly (GO:0007416)2.95796273
125long term synaptic depression (GO:0060292)2.94680844
126regulation of synaptic transmission (GO:0050804)2.93085404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02739841
2GBX2_23144817_ChIP-Seq_PC3_Human3.65906944
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15239559
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08006891
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97304336
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.87294202
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.82955314
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65841165
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65841165
10DROSHA_22980978_ChIP-Seq_HELA_Human2.62271061
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59156182
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57441334
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52689290
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51863116
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48785642
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38160937
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.33000926
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.30859156
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15773994
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.15213036
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13009216
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.12072743
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09587888
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02833296
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02278532
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89774832
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88423357
28TAF15_26573619_Chip-Seq_HEK293_Human1.83131622
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82213159
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80610938
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80079595
32SMAD4_21799915_ChIP-Seq_A2780_Human1.73694529
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70619485
34AR_21572438_ChIP-Seq_LNCaP_Human1.68327464
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62484438
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59843013
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.54789345
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42572303
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41746091
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38253728
41* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36752899
42STAT3_23295773_ChIP-Seq_U87_Human1.34869109
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34025421
44* P300_19829295_ChIP-Seq_ESCs_Human1.33168880
45ZNF274_21170338_ChIP-Seq_K562_Hela1.32266479
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.31752489
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30762859
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.27268744
49* AR_19668381_ChIP-Seq_PC3_Human1.25617898
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24428484
51AR_25329375_ChIP-Seq_VCAP_Human1.22538546
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.22393922
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.18611335
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18422898
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18343000
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17534977
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17438806
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17034009
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16640308
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16116526
61* TCF4_23295773_ChIP-Seq_U87_Human1.14630907
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14060812
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.13736001
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13297235
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13132208
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11299178
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10437157
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09533662
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07912478
70IGF1R_20145208_ChIP-Seq_DFB_Human1.07796768
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07269229
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07205694
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06161748
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06113535
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05880588
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.05506664
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.04814457
78AHR_22903824_ChIP-Seq_MCF-7_Human1.04725453
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00908741
80KDM2B_26808549_Chip-Seq_K562_Human1.00841279
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00427314
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99979799
83RUNX2_22187159_ChIP-Seq_PCA_Human0.99659467
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.99419283
85RING1B_27294783_Chip-Seq_NPCs_Mouse0.98952247
86* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98809572
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.98154684
88ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95407170
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94836764
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94713198
91TP53_16413492_ChIP-PET_HCT116_Human0.94431135
92BCAT_22108803_ChIP-Seq_LS180_Human0.93935937
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93632134
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92812898
95SOX9_26525672_Chip-Seq_HEART_Mouse0.92035967
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.92004820
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91674151
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.91521650
99RNF2_27304074_Chip-Seq_NSC_Mouse0.91215084
100TRIM28_21343339_ChIP-Seq_HEK293_Human0.90883412
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90728148
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90648725
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.90324536
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89927651
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89917415
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88903576
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87866733
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87866733
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87735700
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87529242
111* RXR_22108803_ChIP-Seq_LS180_Human0.85931611
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85729345
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.85494919
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85251216
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85213166
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84936167
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84164600
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81889201
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79727812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.20560923
2MP0003880_abnormal_central_pattern4.68869585
3MP0003635_abnormal_synaptic_transmissio4.17495935
4MP0002822_catalepsy3.99036129
5MP0004270_analgesia3.69723709
6MP0009745_abnormal_behavioral_response3.50925799
7MP0009046_muscle_twitch3.39559601
8MP0002063_abnormal_learning/memory/cond3.29866548
9MP0002064_seizures3.19518406
10MP0001968_abnormal_touch/_nociception2.96138174
11MP0002572_abnormal_emotion/affect_behav2.84296576
12MP0002272_abnormal_nervous_system2.74213238
13MP0002734_abnormal_mechanical_nocicepti2.61069928
14MP0001486_abnormal_startle_reflex2.56022495
15MP0005423_abnormal_somatic_nervous2.54288527
16MP0002909_abnormal_adrenal_gland2.37471406
17MP0001501_abnormal_sleep_pattern2.36018360
18MP0009780_abnormal_chondrocyte_physiolo2.34802842
19MP0004147_increased_porphyrin_level2.16632581
20MP0002735_abnormal_chemical_nociception2.12207446
21MP0002736_abnormal_nociception_after2.11895157
22MP0002733_abnormal_thermal_nociception2.06040993
23MP0002067_abnormal_sensory_capabilities2.00897156
24MP0008569_lethality_at_weaning2.00190459
25MP0005646_abnormal_pituitary_gland2.00172555
26MP0001970_abnormal_pain_threshold1.97558742
27MP0001440_abnormal_grooming_behavior1.94998007
28MP0005386_behavior/neurological_phenoty1.85634213
29MP0004924_abnormal_behavior1.85634213
30MP0003123_paternal_imprinting1.77170365
31MP0002557_abnormal_social/conspecific_i1.73020878
32MP0003879_abnormal_hair_cell1.70616237
33MP0003329_amyloid_beta_deposits1.70226968
34MP0004811_abnormal_neuron_physiology1.69938375
35MP0002184_abnormal_innervation1.68690387
36MP0001984_abnormal_olfaction1.65306035
37MP0004858_abnormal_nervous_system1.59179024
38MP0001529_abnormal_vocalization1.58646898
39MP0006276_abnormal_autonomic_nervous1.50141950
40MP0000955_abnormal_spinal_cord1.46471732
41MP0003633_abnormal_nervous_system1.45194170
42MP0003283_abnormal_digestive_organ1.42263913
43MP0002066_abnormal_motor_capabilities/c1.39980442
44MP0000778_abnormal_nervous_system1.33230135
45MP0002882_abnormal_neuron_morphology1.30350907
46MP0000013_abnormal_adipose_tissue1.30317543
47MP0001905_abnormal_dopamine_level1.26589578
48MP0003787_abnormal_imprinting1.23395907
49MP0010386_abnormal_urinary_bladder1.23182876
50MP0005645_abnormal_hypothalamus_physiol1.22923796
51MP0004145_abnormal_muscle_electrophysio1.22137414
52MP0001502_abnormal_circadian_rhythm1.20816092
53MP0004885_abnormal_endolymph1.19519259
54MP0003631_nervous_system_phenotype1.18078196
55MP0001188_hyperpigmentation1.16481548
56MP0004142_abnormal_muscle_tone1.13515912
57MP0004043_abnormal_pH_regulation1.12663217
58MP0008872_abnormal_physiological_respon1.11608683
59MP0003122_maternal_imprinting1.10713722
60MP0008877_abnormal_DNA_methylation1.08422253
61MP0002229_neurodegeneration1.02227283
62MP0000569_abnormal_digit_pigmentation1.01551439
63MP0005535_abnormal_body_temperature0.99837173
64MP0008874_decreased_physiological_sensi0.97739181
65MP0002152_abnormal_brain_morphology0.96919826
66MP0002837_dystrophic_cardiac_calcinosis0.94774896
67MP0002069_abnormal_eating/drinking_beha0.94333323
68MP0008961_abnormal_basal_metabolism0.90391887
69MP0004085_abnormal_heartbeat0.89387649
70MP0001348_abnormal_lacrimal_gland0.88590394
71MP0001177_atelectasis0.87375339
72MP0005551_abnormal_eye_electrophysiolog0.83044198
73MP0004742_abnormal_vestibular_system0.82376650
74MP0003075_altered_response_to0.82275925
75MP0000751_myopathy0.80469695
76MP0003632_abnormal_nervous_system0.79034133
77MP0003690_abnormal_glial_cell0.78067446
78MP0001986_abnormal_taste_sensitivity0.76646378
79MP0000631_abnormal_neuroendocrine_gland0.74600973
80MP0005409_darkened_coat_color0.74346485
81MP0003634_abnormal_glial_cell0.73504872
82MP0001963_abnormal_hearing_physiology0.72897235
83MP0000920_abnormal_myelination0.71360479
84MP0000604_amyloidosis0.70955155
85MP0003121_genomic_imprinting0.70728922
86MP0003183_abnormal_peptide_metabolism0.68756747
87MP0005394_taste/olfaction_phenotype0.67464409
88MP0005499_abnormal_olfactory_system0.67464409
89MP0002638_abnormal_pupillary_reflex0.66981938
90MP0002090_abnormal_vision0.66870738
91MP0001664_abnormal_digestion0.66230614
92MP0004215_abnormal_myocardial_fiber0.65956012
93MP0001485_abnormal_pinna_reflex0.65560959
94MP0005623_abnormal_meninges_morphology0.64365022
95MP0001346_abnormal_lacrimal_gland0.63152702
96MP0002693_abnormal_pancreas_physiology0.62920193
97MP0005167_abnormal_blood-brain_barrier0.62775764
98MP0002876_abnormal_thyroid_physiology0.62733028
99MP0003172_abnormal_lysosome_physiology0.62563109
100MP0002752_abnormal_somatic_nervous0.60268052
101MP0010234_abnormal_vibrissa_follicle0.57650944
102MP0003137_abnormal_impulse_conducting0.56889993
103MP0010769_abnormal_survival0.56887500
104MP0001299_abnormal_eye_distance/0.56765865
105MP0000639_abnormal_adrenal_gland0.55413600
106MP0000579_abnormal_nail_morphology0.54765487
107MP0005379_endocrine/exocrine_gland_phen0.54435845
108MP0003956_abnormal_body_size0.54038178
109MP0001765_abnormal_ion_homeostasis0.54031127
110MP0010768_mortality/aging0.53432964
111MP0001943_abnormal_respiration0.53073461
112MP0002082_postnatal_lethality0.53029487
113MP0010770_preweaning_lethality0.53029487
114MP0004484_altered_response_of0.52273360
115MP0004233_abnormal_muscle_weight0.51779289
116MP0001731_abnormal_postnatal_growth0.49905027
117MP0000026_abnormal_inner_ear0.49009063
118MP0003861_abnormal_nervous_system0.45751175

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.36995302
2Myokymia (HP:0002411)6.90750034
3Focal seizures (HP:0007359)6.05649042
4Visual hallucinations (HP:0002367)5.46382830
5Atonic seizures (HP:0010819)4.97135310
6Epileptic encephalopathy (HP:0200134)4.79848387
7Febrile seizures (HP:0002373)4.52053995
8Action tremor (HP:0002345)4.44936622
9Absence seizures (HP:0002121)4.39967572
10Progressive cerebellar ataxia (HP:0002073)4.38896182
11Dialeptic seizures (HP:0011146)4.05925046
12Generalized tonic-clonic seizures (HP:0002069)4.04218019
13Gaze-evoked nystagmus (HP:0000640)3.88079069
14Broad-based gait (HP:0002136)3.69049613
15Poor eye contact (HP:0000817)3.63485845
16Truncal ataxia (HP:0002078)3.44348034
17Obstructive sleep apnea (HP:0002870)3.40737989
18Cerebral hypomyelination (HP:0006808)3.39208069
19Dysdiadochokinesis (HP:0002075)3.38077972
20Depression (HP:0000716)3.37750615
21Hyperventilation (HP:0002883)3.37477701
22Abnormal social behavior (HP:0012433)3.32169994
23Impaired social interactions (HP:0000735)3.32169994
24Impaired vibration sensation in the lower limbs (HP:0002166)3.30969537
25Anxiety (HP:0000739)3.24895227
26Impaired smooth pursuit (HP:0007772)3.22870107
27Ankle clonus (HP:0011448)3.20926439
28Supranuclear gaze palsy (HP:0000605)3.15366261
29Dysmetria (HP:0001310)3.13136364
30Papilledema (HP:0001085)3.11657517
31Scanning speech (HP:0002168)3.08187522
32Urinary bladder sphincter dysfunction (HP:0002839)3.01867485
33Dysmetric saccades (HP:0000641)2.93981692
34Postural instability (HP:0002172)2.86819569
35Akinesia (HP:0002304)2.84013253
36Amblyopia (HP:0000646)2.77162646
37Increased circulating renin level (HP:0000848)2.77145498
38Abnormality of ocular smooth pursuit (HP:0000617)2.76837658
39Epileptiform EEG discharges (HP:0011182)2.74664848
40Abnormal eating behavior (HP:0100738)2.73460237
41Resting tremor (HP:0002322)2.69129453
42Peripheral hypomyelination (HP:0007182)2.65058869
43Torticollis (HP:0000473)2.64624822
44EEG with generalized epileptiform discharges (HP:0011198)2.63318839
45Pheochromocytoma (HP:0002666)2.61465651
46Genetic anticipation (HP:0003743)2.60822307
47Intention tremor (HP:0002080)2.57818215
48Hemiparesis (HP:0001269)2.54966234
49Bradykinesia (HP:0002067)2.54143123
50Spastic gait (HP:0002064)2.52554155
51Limb dystonia (HP:0002451)2.52101942
52Drooling (HP:0002307)2.50937027
53Excessive salivation (HP:0003781)2.50937027
54Stereotypic behavior (HP:0000733)2.49886614
55Hypsarrhythmia (HP:0002521)2.49694167
56Hemiplegia (HP:0002301)2.47981444
57Sleep apnea (HP:0010535)2.46766610
58Urinary urgency (HP:0000012)2.46113799
59Focal dystonia (HP:0004373)2.45420745
60Abnormality of the lower motor neuron (HP:0002366)2.41693851
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41625350
62Annular pancreas (HP:0001734)2.40216398
63Status epilepticus (HP:0002133)2.39813683
64Ventricular fibrillation (HP:0001663)2.38661592
65Progressive inability to walk (HP:0002505)2.36889350
66Impaired vibratory sensation (HP:0002495)2.31609515
67Apathy (HP:0000741)2.31109988
68CNS hypomyelination (HP:0003429)2.30610128
69Choreoathetosis (HP:0001266)2.27004492
70Insidious onset (HP:0003587)2.25325283
71Termporal pattern (HP:0011008)2.25325283
72Diplopia (HP:0000651)2.24567661
73Abnormality of binocular vision (HP:0011514)2.24567661
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24527936
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.24527936
76Mutism (HP:0002300)2.22821677
77Agitation (HP:0000713)2.21880017
78Neuroendocrine neoplasm (HP:0100634)2.21729623
79Craniofacial dystonia (HP:0012179)2.21322709
80Cerebral inclusion bodies (HP:0100314)2.18291819
81Gait ataxia (HP:0002066)2.15561508
82Absent speech (HP:0001344)2.15156599
83Megalencephaly (HP:0001355)2.09146791
84Diminished motivation (HP:0000745)2.08920920
85Neurofibrillary tangles (HP:0002185)2.06510668
86Fetal akinesia sequence (HP:0001989)2.05308583
87Postural tremor (HP:0002174)2.04749174
88Insomnia (HP:0100785)2.03892398
89Morphological abnormality of the pyramidal tract (HP:0002062)2.03779203
90Blue irides (HP:0000635)2.00733948
91Inability to walk (HP:0002540)2.00514750
92Spastic tetraparesis (HP:0001285)1.99647656
93Lower limb muscle weakness (HP:0007340)1.99525419
94Abnormality of saccadic eye movements (HP:0000570)1.97287957
95Generalized myoclonic seizures (HP:0002123)1.96530994
96Abnormality of the corticospinal tract (HP:0002492)1.94957131
97Bundle branch block (HP:0011710)1.94046973
98Clonus (HP:0002169)1.93977084
99Abnormal EKG (HP:0003115)1.93929016
100Incomplete penetrance (HP:0003829)1.93840607
101Failure to thrive in infancy (HP:0001531)1.92474706
102Pointed chin (HP:0000307)1.91784723
103Prolonged QT interval (HP:0001657)1.90493366
104Psychosis (HP:0000709)1.88360208
105Rigidity (HP:0002063)1.86918415
106Neuronal loss in central nervous system (HP:0002529)1.85864540
107Ankyloglossia (HP:0010296)1.85781938
108Diminished movement (HP:0002374)1.85045473
109Protruding tongue (HP:0010808)1.84942086
110Rapidly progressive (HP:0003678)1.82238419
111Limb ataxia (HP:0002070)1.79846318
112Spinal canal stenosis (HP:0003416)1.76985223
113Lower limb asymmetry (HP:0100559)1.75115264
114Tetraplegia (HP:0002445)1.74241935
115Ocular albinism (HP:0001107)1.74177629
116Abnormality of the periventricular white matter (HP:0002518)1.70238098
117Iris hypopigmentation (HP:0007730)1.69837329
118Abnormality of salivation (HP:0100755)1.69276792
119Delusions (HP:0000746)1.67724272
120Heart block (HP:0012722)1.66942274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.86837223
2NTRK34.72505314
3MAP3K93.55639313
4MAP3K42.96757965
5DAPK22.83200938
6MINK12.46947190
7MAP2K72.42845797
8PRKD32.32305763
9RIPK42.21852652
10NTRK12.19900755
11KSR22.18606877
12CAMKK12.15861028
13CAMKK22.06811213
14CASK2.06452674
15PAK61.98946177
16MAP2K41.88859725
17MAP3K121.88451763
18NTRK21.85518038
19MARK11.82676620
20DAPK11.77808995
21MAP3K21.56373039
22CDK51.54425196
23CDK191.46649248
24KSR11.46648635
25TNIK1.39509343
26ARAF1.37507739
27GRK51.35249260
28STK381.30912846
29PLK21.24783869
30FES1.22822427
31PNCK1.22374044
32PRPF4B1.21345027
33PRKCG1.16594227
34MAP3K131.14450492
35SIK21.13002970
36UHMK11.12756773
37SGK2231.07389817
38SGK4941.07389817
39MAPK131.05310943
40SGK21.03503561
41PRKCH1.00341444
42CAMK2A0.99369314
43TAOK10.98089932
44TYRO30.97680260
45FGFR20.96554051
46RET0.93941718
47BMPR20.93547276
48CAMK10.90977456
49CAMK2B0.89834092
50STK110.89624343
51SGK30.87518823
52MAP3K10.87147669
53EEF2K0.86527496
54CDK180.81030099
55WNK10.79510900
56INSRR0.78640503
57CDK150.78559802
58OXSR10.77707890
59PINK10.76447794
60CDK140.76417569
61SGK10.75265436
62RAF10.74260960
63PTK2B0.73103555
64SCYL20.72854091
65AKT30.70947255
66PDK10.69413309
67CCNB10.68607318
68PDPK10.67818491
69CDK11A0.66612616
70MAPK120.65776001
71PKN10.65025160
72ALK0.64642109
73CDC42BPA0.61759542
74LMTK20.61727830
75RIPK10.61567356
76MARK20.61418070
77PAK30.59643967
78TNK20.58495007
79CAMK2D0.58401690
80PHKG10.56681670
81PHKG20.56681670
82CAMK1D0.55856318
83CSNK1G20.53486412
84STK390.53473963
85RPS6KA30.52227623
86IRAK20.52222910
87PRKCE0.52126875
88CAMK40.51242163
89DYRK1A0.50289746
90CAMK2G0.50232762
91CAMK1G0.49982592
92NEK60.49585567
93LATS20.45924361
94MAPK100.44478795
95MAP2K10.44335362
96BRAF0.43994339
97FYN0.41691364
98PRKCZ0.41019638
99ROCK20.40988531
100FRK0.40821468
101LIMK10.40503095
102HIPK20.40027668
103DAPK30.39631727
104SIK30.38354858
105FER0.37626047
106MAPKAPK50.36029645
107TESK10.35384773
108PRKCB0.34589210
109BRSK10.34300113
110RPS6KB10.33030254
111CSNK1D0.32998731
112PRKACA0.32414057
113CSNK1A10.32344570

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52918760
2Synaptic vesicle cycle_Homo sapiens_hsa047213.28121679
3Olfactory transduction_Homo sapiens_hsa047402.81043434
4Long-term potentiation_Homo sapiens_hsa047202.76181251
5Circadian entrainment_Homo sapiens_hsa047132.70051884
6Amphetamine addiction_Homo sapiens_hsa050312.68389253
7GABAergic synapse_Homo sapiens_hsa047272.67364136
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64056786
9Morphine addiction_Homo sapiens_hsa050322.55803998
10Glutamatergic synapse_Homo sapiens_hsa047242.55538678
11Insulin secretion_Homo sapiens_hsa049112.37380851
12Dopaminergic synapse_Homo sapiens_hsa047282.26449140
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18769297
14Salivary secretion_Homo sapiens_hsa049702.16478397
15Cocaine addiction_Homo sapiens_hsa050302.00655311
16Cholinergic synapse_Homo sapiens_hsa047252.00282103
17Taste transduction_Homo sapiens_hsa047421.96491588
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92568127
19Gastric acid secretion_Homo sapiens_hsa049711.86740853
20Vitamin B6 metabolism_Homo sapiens_hsa007501.82795091
21Renin secretion_Homo sapiens_hsa049241.74332592
22Serotonergic synapse_Homo sapiens_hsa047261.67188377
23Long-term depression_Homo sapiens_hsa047301.67073254
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67051968
25Oxytocin signaling pathway_Homo sapiens_hsa049211.61721984
26Calcium signaling pathway_Homo sapiens_hsa040201.60334256
27Type II diabetes mellitus_Homo sapiens_hsa049301.47583868
28Collecting duct acid secretion_Homo sapiens_hsa049661.47162612
29GnRH signaling pathway_Homo sapiens_hsa049121.41086615
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38824541
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35148215
32Gap junction_Homo sapiens_hsa045401.33782533
33cAMP signaling pathway_Homo sapiens_hsa040241.29725366
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29365431
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24770898
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19420611
37Estrogen signaling pathway_Homo sapiens_hsa049151.17152995
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07275017
39Pancreatic secretion_Homo sapiens_hsa049721.07112721
40Vibrio cholerae infection_Homo sapiens_hsa051101.03251159
41Glioma_Homo sapiens_hsa052141.03010974
42Nitrogen metabolism_Homo sapiens_hsa009101.01615650
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00075667
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.96248017
45Melanogenesis_Homo sapiens_hsa049160.95346333
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93897199
47Cardiac muscle contraction_Homo sapiens_hsa042600.91287447
48Thyroid hormone synthesis_Homo sapiens_hsa049180.89845148
49ErbB signaling pathway_Homo sapiens_hsa040120.88710409
50Dorso-ventral axis formation_Homo sapiens_hsa043200.84689374
51Type I diabetes mellitus_Homo sapiens_hsa049400.84337616
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82175459
53Oocyte meiosis_Homo sapiens_hsa041140.81925954
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80929062
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.79144491
56Phototransduction_Homo sapiens_hsa047440.76086451
57Fatty acid biosynthesis_Homo sapiens_hsa000610.75447756
58Axon guidance_Homo sapiens_hsa043600.74611118
59Dilated cardiomyopathy_Homo sapiens_hsa054140.69727197
60Glucagon signaling pathway_Homo sapiens_hsa049220.68562927
61MAPK signaling pathway_Homo sapiens_hsa040100.67235290
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66749488
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65231856
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63279873
65Circadian rhythm_Homo sapiens_hsa047100.63278255
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.61677860
67Choline metabolism in cancer_Homo sapiens_hsa052310.61284117
68Inositol phosphate metabolism_Homo sapiens_hsa005620.59775081
69Alcoholism_Homo sapiens_hsa050340.58462179
70mTOR signaling pathway_Homo sapiens_hsa041500.53947453
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53329594
72Arginine and proline metabolism_Homo sapiens_hsa003300.51440937
73VEGF signaling pathway_Homo sapiens_hsa043700.51046271
74Rap1 signaling pathway_Homo sapiens_hsa040150.50100128
75Bile secretion_Homo sapiens_hsa049760.49857093
76Ras signaling pathway_Homo sapiens_hsa040140.49213796
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48904140
78Arginine biosynthesis_Homo sapiens_hsa002200.48522050
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47887334
80Mineral absorption_Homo sapiens_hsa049780.45946128
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45682895
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45305323
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.44536776
84Histidine metabolism_Homo sapiens_hsa003400.43213377
85Prion diseases_Homo sapiens_hsa050200.42335221
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.41992196
87beta-Alanine metabolism_Homo sapiens_hsa004100.41138421
88Endocytosis_Homo sapiens_hsa041440.40882452
89Non-small cell lung cancer_Homo sapiens_hsa052230.40617215
90Insulin signaling pathway_Homo sapiens_hsa049100.40417428
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40009223
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39374817
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37800289
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37621748
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36819383
96ABC transporters_Homo sapiens_hsa020100.36360111
97AMPK signaling pathway_Homo sapiens_hsa041520.35242258
98Ovarian steroidogenesis_Homo sapiens_hsa049130.35157514
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33813110
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33311661
101Alzheimers disease_Homo sapiens_hsa050100.33302745
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33033930
103Endometrial cancer_Homo sapiens_hsa052130.32751176
104African trypanosomiasis_Homo sapiens_hsa051430.32145006
105Chemokine signaling pathway_Homo sapiens_hsa040620.31930557
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30918959
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29682717
108Prolactin signaling pathway_Homo sapiens_hsa049170.28517399
109Renal cell carcinoma_Homo sapiens_hsa052110.28262568
110Wnt signaling pathway_Homo sapiens_hsa043100.28236065
111Fatty acid metabolism_Homo sapiens_hsa012120.26885336
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.26087462
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25993849
114Tight junction_Homo sapiens_hsa045300.25500922
115Butanoate metabolism_Homo sapiens_hsa006500.24450551

Most similar genes based on co-expression Upload to Enrichr

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