GPR161

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)7.88865664
2melanin metabolic process (GO:0006582)7.08020561
3secondary metabolite biosynthetic process (GO:0044550)6.94406047
4positive regulation of synapse maturation (GO:0090129)4.65215861
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.48732331
6neuron recognition (GO:0008038)4.41276363
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36087517
8axonal fasciculation (GO:0007413)4.33373633
9tachykinin receptor signaling pathway (GO:0007217)4.29940365
10cell migration in hindbrain (GO:0021535)4.24255839
11dendritic spine morphogenesis (GO:0060997)4.20728714
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.19371133
13neuron cell-cell adhesion (GO:0007158)4.11493627
14positive regulation of action potential (GO:0045760)4.05673896
15nucleobase catabolic process (GO:0046113)3.95255957
16layer formation in cerebral cortex (GO:0021819)3.90008161
17glutamate receptor signaling pathway (GO:0007215)3.89624733
18central nervous system projection neuron axonogenesis (GO:0021952)3.88572839
19presynaptic membrane organization (GO:0097090)3.85513574
20positive regulation of vascular permeability (GO:0043117)3.82275306
21protein localization to synapse (GO:0035418)3.78753398
22vocalization behavior (GO:0071625)3.75996568
23regulation of synapse maturation (GO:0090128)3.72048467
24regulation of glutamate receptor signaling pathway (GO:1900449)3.68473936
25positive regulation of dendritic spine morphogenesis (GO:0061003)3.64152411
26exploration behavior (GO:0035640)3.63861414
27lung-associated mesenchyme development (GO:0060484)3.60583837
28locomotory exploration behavior (GO:0035641)3.60151504
29innervation (GO:0060384)3.59507073
30behavioral response to nicotine (GO:0035095)3.57275407
31phenol-containing compound biosynthetic process (GO:0046189)3.53719901
32axon extension involved in axon guidance (GO:0048846)3.52927974
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.52927974
34synaptic transmission, glutamatergic (GO:0035249)3.51588017
35urinary tract smooth muscle contraction (GO:0014848)3.51131043
36dendritic spine organization (GO:0097061)3.50524120
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44866095
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42631105
39negative regulation of axon guidance (GO:1902668)3.41684788
40behavioral defense response (GO:0002209)3.39905213
41behavioral fear response (GO:0001662)3.39905213
42negative regulation of axon extension involved in axon guidance (GO:0048843)3.36847193
43ganglion development (GO:0061548)3.36801445
44limb bud formation (GO:0060174)3.28469649
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28459926
46synaptic vesicle endocytosis (GO:0048488)3.28260665
47behavioral response to ethanol (GO:0048149)3.26107715
48axon extension (GO:0048675)3.24071927
49cerebral cortex radially oriented cell migration (GO:0021799)3.19417328
50ephrin receptor signaling pathway (GO:0048013)3.16192492
51regulation of dendritic spine morphogenesis (GO:0061001)3.15113879
52regulation of action potential (GO:0098900)3.07988305
53sympathetic nervous system development (GO:0048485)3.07449912
54inner ear receptor cell development (GO:0060119)3.07204131
55fear response (GO:0042596)3.06422410
56neuron-neuron synaptic transmission (GO:0007270)3.04903514
57dendrite morphogenesis (GO:0048813)3.04713327
58spinal cord development (GO:0021510)3.04294879
59olfactory bulb development (GO:0021772)3.03659138
60paraxial mesoderm development (GO:0048339)3.02576857
61postsynaptic membrane organization (GO:0001941)3.01608847
62regulation of neuronal synaptic plasticity (GO:0048168)3.00110230
63central nervous system neuron axonogenesis (GO:0021955)2.99487787
64neuron projection extension (GO:1990138)2.98824906
65cornea development in camera-type eye (GO:0061303)2.93370634
66retinal ganglion cell axon guidance (GO:0031290)2.90518652
67cochlea development (GO:0090102)2.88910928
68response to auditory stimulus (GO:0010996)2.88880859
69melanosome organization (GO:0032438)2.83191061
70startle response (GO:0001964)2.82687797
71synaptic vesicle exocytosis (GO:0016079)2.79956700
72pyrimidine nucleobase catabolic process (GO:0006208)2.79861981
73positive regulation of filopodium assembly (GO:0051491)2.78192730
74synaptic transmission, cholinergic (GO:0007271)2.76789188
75developmental pigmentation (GO:0048066)2.69671154
76hippocampus development (GO:0021766)2.69340012
77establishment of nucleus localization (GO:0040023)2.69004881
78positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67545161
79regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.66815127
80negative chemotaxis (GO:0050919)2.65859673
81regulation of synapse structural plasticity (GO:0051823)2.64651679
82developmental cell growth (GO:0048588)2.63254481
83hindbrain development (GO:0030902)2.63203876
84pigment granule organization (GO:0048753)2.62078941
85proline transport (GO:0015824)2.59311234
86regulation of synaptic vesicle transport (GO:1902803)2.59180007
87synaptic vesicle docking involved in exocytosis (GO:0016081)2.58563929
88positive regulation of dendritic spine development (GO:0060999)2.58525920
89dendrite development (GO:0016358)2.58014082
90glycosphingolipid biosynthetic process (GO:0006688)2.56573749
91positive regulation of uterine smooth muscle contraction (GO:0070474)2.56349861
92long-term memory (GO:0007616)2.55792551
93cerebellum development (GO:0021549)2.55350395
94regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54842864
95microtubule depolymerization (GO:0007019)2.52507415
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51445314
97regulation of synaptic vesicle exocytosis (GO:2000300)2.51390245
98righting reflex (GO:0060013)2.51388182
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51330185
100positive regulation of synapse assembly (GO:0051965)2.50146385
101regulation of synapse organization (GO:0050807)2.50042062
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49957434
103regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49007848
104acrosome reaction (GO:0007340)2.48978724
105regulation of development, heterochronic (GO:0040034)2.48208580
106regulation of synaptic plasticity (GO:0048167)2.46627306
107regulation of postsynaptic membrane potential (GO:0060078)2.46423699
108regulation of timing of cell differentiation (GO:0048505)2.45256109
109positive regulation of neuroblast proliferation (GO:0002052)2.44845461
110mitochondrion transport along microtubule (GO:0047497)2.44541613
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.44541613
112presynaptic membrane assembly (GO:0097105)2.44527159
113regulation of axon extension involved in axon guidance (GO:0048841)2.44360973
114peptidyl-arginine N-methylation (GO:0035246)2.42971151
115peptidyl-arginine methylation (GO:0018216)2.42971151
116regulation of uterine smooth muscle contraction (GO:0070472)2.42696479
117glutamate secretion (GO:0014047)2.42501728
118cerebellar granule cell differentiation (GO:0021707)2.41858669
119vitamin transmembrane transport (GO:0035461)2.41590777
120regulation of synaptic transmission, GABAergic (GO:0032228)2.40799240
121peptidyl-threonine dephosphorylation (GO:0035970)2.40448504
122neuromuscular process controlling balance (GO:0050885)2.39848104
123neuron remodeling (GO:0016322)2.38964723
124regulation of axon extension (GO:0030516)2.38068862
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37066415
126negative regulation of axon extension (GO:0030517)2.35377736
127regulation of dendritic spine development (GO:0060998)2.35361305
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.35222588
129social behavior (GO:0035176)2.34644904
130intraspecies interaction between organisms (GO:0051703)2.34644904
131cerebral cortex cell migration (GO:0021795)2.33708957
132head development (GO:0060322)2.32961118
133peptidyl-arginine omega-N-methylation (GO:0035247)2.32878125
134regulation of synapse assembly (GO:0051963)2.31849346
135establishment of mitochondrion localization (GO:0051654)2.31338005
136melanocyte differentiation (GO:0030318)2.31320994
137organelle transport along microtubule (GO:0072384)2.31059585
138regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30997164
139synaptic vesicle maturation (GO:0016188)2.30466356
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30408968
141neuroepithelial cell differentiation (GO:0060563)2.29286607
142neuron migration (GO:0001764)2.29152834
143chemosensory behavior (GO:0007635)2.28807728
144appendage development (GO:0048736)2.28795842
145limb development (GO:0060173)2.28795842
146regulation of axon guidance (GO:1902667)2.28525604
147intraciliary transport (GO:0042073)2.28381079
148aggressive behavior (GO:0002118)2.28318669
149cytoplasmic mRNA processing body assembly (GO:0033962)2.28108603
150response to histamine (GO:0034776)2.27332160
151synapse assembly (GO:0007416)2.26903919
152learning (GO:0007612)2.26795706
153retinal rod cell development (GO:0046548)2.26731012
154regulation of filopodium assembly (GO:0051489)2.25833494
155regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.25718968
156transmission of nerve impulse (GO:0019226)2.25174850
157regulation of DNA endoreduplication (GO:0032875)2.21622560
158mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.21586914
159regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.21403020
160nonmotile primary cilium assembly (GO:0035058)2.20378982
161pigment cell differentiation (GO:0050931)2.20011488
162lateral sprouting from an epithelium (GO:0060601)2.19854212
163inner ear receptor stereocilium organization (GO:0060122)2.19800857
164dorsal/ventral axis specification (GO:0009950)2.17039289
165somite development (GO:0061053)2.13387791
166negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.12813843
167embryonic foregut morphogenesis (GO:0048617)2.12563914
168inositol phosphate catabolic process (GO:0071545)2.10319771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89115679
2GBX2_23144817_ChIP-Seq_PC3_Human2.95136957
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83476293
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77436244
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.51998002
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45983962
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44141303
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42174682
9ZNF274_21170338_ChIP-Seq_K562_Hela2.38421999
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33614926
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.22594448
12REST_21632747_ChIP-Seq_MESCs_Mouse2.21871806
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20970402
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20970402
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20818418
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15420062
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13859846
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10113434
19TAF15_26573619_Chip-Seq_HEK293_Human2.08974805
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08595808
21VDR_22108803_ChIP-Seq_LS180_Human2.06959942
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01961317
23* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97924102
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.93407656
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85450242
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81280876
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79724324
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75347040
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75025710
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72192578
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71271492
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.67585618
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67177477
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64803673
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62053974
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61680844
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60944940
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58575867
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.57877111
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56373824
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55425706
42AR_21572438_ChIP-Seq_LNCaP_Human1.53894801
43FUS_26573619_Chip-Seq_HEK293_Human1.52689591
44ZNF263_19887448_ChIP-Seq_K562_Human1.50019078
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48231730
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47561330
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.44689285
48* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42793713
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.38287083
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.37074188
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.36679801
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35174667
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33644871
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32905149
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.32515966
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30835241
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26279023
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25044731
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23483166
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23337037
61CBP_20019798_ChIP-Seq_JUKART_Human1.23337037
62TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23088644
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22627883
64RNF2_27304074_Chip-Seq_NSC_Mouse1.19998234
65* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19917985
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19648100
67AR_25329375_ChIP-Seq_VCAP_Human1.18922013
68P300_19829295_ChIP-Seq_ESCs_Human1.18874361
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.18195611
70DROSHA_22980978_ChIP-Seq_HELA_Human1.17505522
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17435860
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17240274
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17165359
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.16701771
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16689990
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16524508
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15087620
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14516588
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14489740
80STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14246907
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13685825
82AHR_22903824_ChIP-Seq_MCF-7_Human1.13132485
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13006565
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12872881
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.12201393
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11765773
87* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10764098
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10317329
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09446027
90IGF1R_20145208_ChIP-Seq_DFB_Human1.08895436
91TP53_16413492_ChIP-PET_HCT116_Human1.08035716
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.07283783
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06441306
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06441306
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05916178
96EWS_26573619_Chip-Seq_HEK293_Human1.04182982
97JUN_21703547_ChIP-Seq_K562_Human1.03341830
98TCF4_23295773_ChIP-Seq_U87_Human1.02929844
99AR_19668381_ChIP-Seq_PC3_Human1.02604110
100RUNX2_22187159_ChIP-Seq_PCA_Human1.02369673
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.01952833
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.01708419
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.01707356
104* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01063467
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00850897
106BCAT_22108803_ChIP-Seq_LS180_Human1.00811812
107ER_23166858_ChIP-Seq_MCF-7_Human1.00316444
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00224409
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00222165
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00044501
111STAT3_23295773_ChIP-Seq_U87_Human0.99875027
112TP53_18474530_ChIP-ChIP_U2OS_Human0.99587306
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99570105
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98735501
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.98706667
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98052510
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.96922842
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96224212
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95775133
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94490351
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94212273
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90907741
123* SOX9_26525672_Chip-Seq_HEART_Mouse0.89283700
124* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88543033
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88428722
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87727495
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87444280
128* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86747674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.21539563
2MP0004859_abnormal_synaptic_plasticity5.09622466
3MP0003880_abnormal_central_pattern4.29536681
4MP0003136_yellow_coat_color4.12735343
5MP0005171_absent_coat_pigmentation4.11417445
6MP0003635_abnormal_synaptic_transmissio2.88131007
7MP0004270_analgesia2.84715508
8MP0002063_abnormal_learning/memory/cond2.57559721
9MP0000778_abnormal_nervous_system2.57267030
10MP0005408_hypopigmentation2.51056609
11MP0000015_abnormal_ear_pigmentation2.20502355
12MP0001968_abnormal_touch/_nociception2.07107322
13MP0002184_abnormal_innervation2.02943192
14MP0002735_abnormal_chemical_nociception1.97804413
15MP0001529_abnormal_vocalization1.97483365
16MP0002095_abnormal_skin_pigmentation1.94306748
17MP0002734_abnormal_mechanical_nocicepti1.93151303
18MP0005423_abnormal_somatic_nervous1.89477857
19MP0000537_abnormal_urethra_morphology1.89265365
20MP0003938_abnormal_ear_development1.87897813
21MP0000569_abnormal_digit_pigmentation1.85511933
22MP0002572_abnormal_emotion/affect_behav1.85421870
23MP0002736_abnormal_nociception_after1.84361326
24MP0002234_abnormal_pharynx_morphology1.79886035
25MP0006292_abnormal_olfactory_placode1.79516956
26MP0009745_abnormal_behavioral_response1.78914847
27MP0003123_paternal_imprinting1.78198033
28MP0006276_abnormal_autonomic_nervous1.77200479
29MP0002102_abnormal_ear_morphology1.75214340
30MP0001440_abnormal_grooming_behavior1.70644271
31MP0001324_abnormal_eye_pigmentation1.68136849
32MP0001188_hyperpigmentation1.64562726
33MP0002064_seizures1.63528554
34MP0004885_abnormal_endolymph1.56161108
35MP0005174_abnormal_tail_pigmentation1.55341520
36* MP0002938_white_spotting1.52051624
37MP0004858_abnormal_nervous_system1.50019714
38MP0002638_abnormal_pupillary_reflex1.49520536
39MP0005075_abnormal_melanosome_morpholog1.47237898
40MP0005377_hearing/vestibular/ear_phenot1.47058527
41MP0003878_abnormal_ear_physiology1.47058527
42MP0005187_abnormal_penis_morphology1.45674111
43MP0004811_abnormal_neuron_physiology1.38375752
44MP0000955_abnormal_spinal_cord1.36802156
45* MP0003861_abnormal_nervous_system1.35795831
46MP0002272_abnormal_nervous_system1.34309798
47MP0003122_maternal_imprinting1.33719343
48MP0003119_abnormal_digestive_system1.33312951
49MP0001486_abnormal_startle_reflex1.31855927
50MP0004133_heterotaxia1.31287874
51MP0002733_abnormal_thermal_nociception1.30681694
52MP0003941_abnormal_skin_development1.29623193
53MP0005197_abnormal_uvea_morphology1.29539128
54MP0000371_diluted_coat_color1.29289327
55MP0002067_abnormal_sensory_capabilities1.28041856
56MP0009046_muscle_twitch1.25523992
57MP0002557_abnormal_social/conspecific_i1.25013956
58MP0001984_abnormal_olfaction1.24173992
59MP0002822_catalepsy1.23817185
60MP0003787_abnormal_imprinting1.22943701
61MP0003890_abnormal_embryonic-extraembry1.22782318
62MP0002152_abnormal_brain_morphology1.22504524
63MP0005367_renal/urinary_system_phenotyp1.21487104
64MP0000516_abnormal_urinary_system1.21487104
65MP0001970_abnormal_pain_threshold1.21346782
66MP0001293_anophthalmia1.21165737
67MP0001501_abnormal_sleep_pattern1.20083806
68MP0001299_abnormal_eye_distance/1.20076088
69MP0003121_genomic_imprinting1.18361285
70MP0009379_abnormal_foot_pigmentation1.17977940
71MP0005253_abnormal_eye_physiology1.16351329
72MP0002882_abnormal_neuron_morphology1.15005138
73MP0000049_abnormal_middle_ear1.12456505
74MP0005257_abnormal_intraocular_pressure1.12355064
75MP0003755_abnormal_palate_morphology1.12085766
76MP0005503_abnormal_tendon_morphology1.11570462
77MP0005623_abnormal_meninges_morphology1.11397897
78MP0000428_abnormal_craniofacial_morphol1.10282492
79MP0003937_abnormal_limbs/digits/tail_de1.09565083
80MP0009780_abnormal_chondrocyte_physiolo1.09063777
81MP0002697_abnormal_eye_size1.07229438
82MP0003315_abnormal_perineum_morphology1.05735598
83MP0003111_abnormal_nucleus_morphology1.05242481
84MP0003385_abnormal_body_wall1.04636494
85MP0008260_abnormal_autophagy1.04240570
86MP0005391_vision/eye_phenotype1.03856643
87MP0003329_amyloid_beta_deposits1.02044699
88MP0000678_abnormal_parathyroid_gland1.01873238
89MP0002909_abnormal_adrenal_gland0.99167757
90MP0005394_taste/olfaction_phenotype0.99141977
91MP0005499_abnormal_olfactory_system0.99141977
92MP0000534_abnormal_ureter_morphology0.99010926
93MP0000631_abnormal_neuroendocrine_gland0.98052574
94MP0004924_abnormal_behavior0.97897561
95MP0005386_behavior/neurological_phenoty0.97897561
96MP0008789_abnormal_olfactory_epithelium0.97261039
97MP0005409_darkened_coat_color0.96794938
98MP0002075_abnormal_coat/hair_pigmentati0.96335251
99* MP0002066_abnormal_motor_capabilities/c0.95828212
100MP0002092_abnormal_eye_morphology0.94585961
101MP0003646_muscle_fatigue0.94467304
102MP0000566_synostosis0.93559227
103MP0001286_abnormal_eye_development0.92403782
104MP0003879_abnormal_hair_cell0.92224576
105MP0005551_abnormal_eye_electrophysiolog0.89894623
106MP0002233_abnormal_nose_morphology0.89636755
107MP0001186_pigmentation_phenotype0.86777676
108MP0002116_abnormal_craniofacial_bone0.85828500
109MP0000681_abnormal_thyroid_gland0.85643272
110MP0003935_abnormal_craniofacial_develop0.85308529
111MP0002090_abnormal_vision0.84369137
112MP0002177_abnormal_outer_ear0.84345515
113MP0005195_abnormal_posterior_eye0.84041007
114MP0003942_abnormal_urinary_system0.83893649
115MP0000647_abnormal_sebaceous_gland0.83482659
116MP0003115_abnormal_respiratory_system0.82542739
117MP0005248_abnormal_Harderian_gland0.82404391
118MP0002653_abnormal_ependyma_morphology0.81037730
119MP0002837_dystrophic_cardiac_calcinosis0.79958352
120MP0002081_perinatal_lethality0.79722482
121MP0003283_abnormal_digestive_organ0.79616476
122MP0004142_abnormal_muscle_tone0.78254523
123MP0004381_abnormal_hair_follicle0.78058271
124MP0009053_abnormal_anal_canal0.77787286
125MP0000026_abnormal_inner_ear0.76801214
126MP0004145_abnormal_muscle_electrophysio0.76672912
127MP0009250_abnormal_appendicular_skeleto0.74692705
128MP0002752_abnormal_somatic_nervous0.73664937
129MP0008438_abnormal_cutaneous_collagen0.73618670
130MP0002084_abnormal_developmental_patter0.72925179
131MP0003718_maternal_effect0.72440127
132MP0002249_abnormal_larynx_morphology0.71257580
133MP0003567_abnormal_fetal_cardiomyocyte0.68930437
134MP0010030_abnormal_orbit_morphology0.68903333
135MP0005508_abnormal_skeleton_morphology0.68697595
136MP0001905_abnormal_dopamine_level0.67922547
137MP0002751_abnormal_autonomic_nervous0.67785344
138* MP0002085_abnormal_embryonic_tissue0.67549649
139MP0002114_abnormal_axial_skeleton0.67525083

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)4.31325999
2Aplasia/Hypoplasia affecting the retina (HP:0008061)4.00826743
3Focal motor seizures (HP:0011153)3.87391860
4Blue irides (HP:0000635)3.76806245
5Hypoplasia of the fovea (HP:0007750)3.71823732
6Aplasia/Hypoplasia of the fovea (HP:0008060)3.71823732
7Iris hypopigmentation (HP:0007730)3.22619315
8Drooling (HP:0002307)3.19808311
9Excessive salivation (HP:0003781)3.19808311
10Focal seizures (HP:0007359)3.13906946
11Abnormality of the fovea (HP:0000493)3.09185133
12Ocular albinism (HP:0001107)3.03924038
13Hypopigmentation of the fundus (HP:0007894)3.01252220
14Visual hallucinations (HP:0002367)2.94035765
15Facial hemangioma (HP:0000329)2.88306263
16Intestinal atresia (HP:0011100)2.85417517
17White forelock (HP:0002211)2.83344063
18Premature rupture of membranes (HP:0001788)2.77358517
19Shoulder girdle muscle weakness (HP:0003547)2.74067677
20Mutism (HP:0002300)2.74013691
21Fibular hypoplasia (HP:0003038)2.72764273
22Patchy hypopigmentation of hair (HP:0011365)2.70460851
23Myokymia (HP:0002411)2.63776907
24Abnormality of the labia minora (HP:0012880)2.63386791
25Morphological abnormality of the middle ear (HP:0008609)2.60399819
26Shallow orbits (HP:0000586)2.56054058
27Amyotrophic lateral sclerosis (HP:0007354)2.48452661
28Broad-based gait (HP:0002136)2.47255842
29Generalized hypopigmentation (HP:0007513)2.42010349
30Neonatal short-limb short stature (HP:0008921)2.39837802
31Vitreoretinal degeneration (HP:0000655)2.38801579
32Supranuclear gaze palsy (HP:0000605)2.37180521
33Wrist flexion contracture (HP:0001239)2.36347300
34Cortical dysplasia (HP:0002539)2.33499801
35Aqueductal stenosis (HP:0002410)2.32782967
36Progressive cerebellar ataxia (HP:0002073)2.28484706
37Oligodactyly (hands) (HP:0001180)2.27151833
38Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.26984377
39Bifid tongue (HP:0010297)2.26427912
40Congenital stationary night blindness (HP:0007642)2.24635791
41Long clavicles (HP:0000890)2.23529105
42Genetic anticipation (HP:0003743)2.21465840
43Amblyopia (HP:0000646)2.19704280
44Facial cleft (HP:0002006)2.18908832
45Pelvic girdle muscle weakness (HP:0003749)2.17355384
46Abnormal auditory evoked potentials (HP:0006958)2.15910820
47Megalencephaly (HP:0001355)2.12962433
48Abnormality of midbrain morphology (HP:0002418)2.11272036
49Molar tooth sign on MRI (HP:0002419)2.11272036
50Aplasia/Hypoplasia of the fibula (HP:0006492)2.11141416
51Absence seizures (HP:0002121)2.09955122
52Bundle branch block (HP:0011710)2.09060488
53Abnormality of the lower motor neuron (HP:0002366)2.08628384
54Rib fusion (HP:0000902)2.08062450
55Freckling (HP:0001480)2.06921400
56Epileptic encephalopathy (HP:0200134)2.06334745
57Atonic seizures (HP:0010819)2.06089561
58Gait imbalance (HP:0002141)2.05704903
59Delusions (HP:0000746)2.05658667
60Dialeptic seizures (HP:0011146)2.04767593
61Oligodactyly (HP:0012165)2.04651608
62Abnormality of salivation (HP:0100755)2.02884525
63Nephronophthisis (HP:0000090)2.02542674
64Cerebral inclusion bodies (HP:0100314)2.01754339
65Hydroureter (HP:0000072)1.98742684
66Anophthalmia (HP:0000528)1.98150089
67Abnormality of the ischium (HP:0003174)1.98128049
68Exotropia (HP:0000577)1.98090627
69Termporal pattern (HP:0011008)1.96543782
70Insidious onset (HP:0003587)1.96543782
71Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96140112
72Short 1st metacarpal (HP:0010034)1.96140112
73Abnormality of the hip-girdle musculature (HP:0001445)1.95034265
74Abnormality of the musculature of the pelvis (HP:0001469)1.95034265
75Renal dysplasia (HP:0000110)1.94866996
76Astigmatism (HP:0000483)1.94498889
77Heterochromia iridis (HP:0001100)1.91165119
78Double outlet right ventricle (HP:0001719)1.88514734
79Congenital malformation of the right heart (HP:0011723)1.88514734
80Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88075022
81Short 4th metacarpal (HP:0010044)1.88075022
82Fetal akinesia sequence (HP:0001989)1.88005949
83Restlessness (HP:0000711)1.87505436
84Dysautonomia (HP:0002459)1.86866991
85Postaxial hand polydactyly (HP:0001162)1.86831761
86Postaxial foot polydactyly (HP:0001830)1.86352819
87Ventricular fibrillation (HP:0001663)1.85958047
88Gastrointestinal atresia (HP:0002589)1.85749159
89Microglossia (HP:0000171)1.85555251
90Breast hypoplasia (HP:0003187)1.84313420
91Hypoplastic ischia (HP:0003175)1.82959653
92Hyperventilation (HP:0002883)1.80273837
93Anterior segment dysgenesis (HP:0007700)1.80182190
94Lissencephaly (HP:0001339)1.79724611
95Preaxial hand polydactyly (HP:0001177)1.78518751
96Pancreatic fibrosis (HP:0100732)1.76755082
97Long nose (HP:0003189)1.76701833
98Absent speech (HP:0001344)1.76544853
99Medial flaring of the eyebrow (HP:0010747)1.75113092
100Ankle contracture (HP:0006466)1.74150018
101Hypoplasia of the iris (HP:0007676)1.73274646
102Pachygyria (HP:0001302)1.71884943
103Cutaneous finger syndactyly (HP:0010554)1.71830695
104Truncus arteriosus (HP:0001660)1.71569906
105Renal hypoplasia (HP:0000089)1.71460951
106Abnormality of the corticospinal tract (HP:0002492)1.71379067
107Abnormality of the 4th metacarpal (HP:0010012)1.70897962
108Gastroesophageal reflux (HP:0002020)1.69924297
109Volvulus (HP:0002580)1.69831525
110Birth length less than 3rd percentile (HP:0003561)1.69544603
111Retinal dysplasia (HP:0007973)1.68866136
112Buphthalmos (HP:0000557)1.68701860
113Febrile seizures (HP:0002373)1.68699029
114Megalocornea (HP:0000485)1.68645647
115Poor eye contact (HP:0000817)1.68170588
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.68162360
117Pancreatic cysts (HP:0001737)1.68135237
118True hermaphroditism (HP:0010459)1.68122348
119Short clavicles (HP:0000894)1.68105032
120Keratoconus (HP:0000563)1.65745071
121Increased corneal curvature (HP:0100692)1.65745071
122Epileptiform EEG discharges (HP:0011182)1.65442248
123Limb dystonia (HP:0002451)1.65373037
124High anterior hairline (HP:0009890)1.65136149
125Aplasia/Hypoplasia of the patella (HP:0006498)1.64818817
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.64383401
127Complete atrioventricular canal defect (HP:0001674)1.64200540
128Aplasia/Hypoplasia of the clavicles (HP:0006710)1.64184149
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64157122
130Abnormality of the renal medulla (HP:0100957)1.64142631
131Coronal craniosynostosis (HP:0004440)1.63921260
132Shawl scrotum (HP:0000049)1.63510972
133Abnormality of the antihelix (HP:0009738)1.63191400
134Apathy (HP:0000741)1.62910698
135Congenital sensorineural hearing impairment (HP:0008527)1.62225912
136Narrow forehead (HP:0000341)1.61988426
137Generalized tonic-clonic seizures (HP:0002069)1.61747645
138Small hand (HP:0200055)1.61630296
139Neoplasm of the adrenal cortex (HP:0100641)1.61376377
140Genital tract atresia (HP:0001827)1.60751478
141Action tremor (HP:0002345)1.60696483
142Natal tooth (HP:0000695)1.60333053
143Abnormality of the 1st metacarpal (HP:0010009)1.60130600
144Hypoplasia of the brainstem (HP:0002365)1.59461108
145Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59461108
146Patellar aplasia (HP:0006443)1.59454089
147Abnormality of the astrocytes (HP:0100707)1.59191112
148Astrocytoma (HP:0009592)1.59191112
149Urinary bladder sphincter dysfunction (HP:0002839)1.58654859
150Vaginal atresia (HP:0000148)1.58494726
151Intellectual disability, moderate (HP:0002342)1.58163521
152Congenital primary aphakia (HP:0007707)1.57610334
153Septo-optic dysplasia (HP:0100842)1.57095669
154Hypoplastic nipples (HP:0002557)1.56882350
155Insomnia (HP:0100785)1.56282392
156Absent eyebrow (HP:0002223)1.55730728
157Hemiparesis (HP:0001269)1.55131476
158Midline defect of the nose (HP:0004122)1.54806688
159Wide anterior fontanel (HP:0000260)1.54385265
160Meckel diverticulum (HP:0002245)1.54364314
161Short ribs (HP:0000773)1.53871451
162Optic nerve hypoplasia (HP:0000609)1.53763729
163Abnormality of the ileum (HP:0001549)1.53683257
164Enlarged penis (HP:0000040)1.53291394
165Hyperthyroidism (HP:0000836)1.53157286
166Impaired vibration sensation in the lower limbs (HP:0002166)1.52852080
167Impaired smooth pursuit (HP:0007772)1.51874340
168Sporadic (HP:0003745)1.51582980
169Bronchomalacia (HP:0002780)1.51389640
170Difficulty climbing stairs (HP:0003551)1.50539714
171Autism (HP:0000717)1.49689928
172Impaired social interactions (HP:0000735)1.48966835
173Abnormal social behavior (HP:0012433)1.48966835
174Truncal ataxia (HP:0002078)1.47688614
175EEG with generalized epileptiform discharges (HP:0011198)1.47371388
176Cutaneous syndactyly (HP:0012725)1.46544528
177Hypoplasia of the maxilla (HP:0000327)1.45875306
178Atrioventricular canal defect (HP:0006695)1.45409964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.24423601
2NTRK34.20383096
3EPHA43.70513576
4LATS23.00404608
5PNCK2.98841868
6MAP3K92.82114701
7TNIK2.20788743
8AKT32.16886156
9MAP3K42.11852107
10MINK12.05056687
11BMPR1B1.80995682
12RIPK41.80822194
13BUB11.77504330
14KSR11.76936977
15PLK21.75438648
16TRIM281.75403966
17MAP4K21.68596475
18PAK61.65462708
19SIK21.56775423
20MAP2K71.55919210
21LATS11.54172349
22MAPK131.52830627
23NTRK21.52248961
24EPHB21.51954956
25NUAK11.49215337
26PRKD31.46826011
27DYRK21.45800596
28CASK1.39034418
29PLK31.38936602
30TSSK61.26702357
31NME11.24624515
32DDR21.20948838
33ERBB31.20579289
34FRK1.20471935
35STK381.20052466
36PRKCG1.19607927
37TIE11.17613847
38EPHA21.15975284
39WEE11.15370002
40PAK31.10531167
41PDGFRA1.07743407
42MKNK21.07587510
43CSNK1G21.05121685
44MAP2K41.04656180
45NEK21.03125924
46KSR21.02329025
47SRPK10.96856074
48STK38L0.93052769
49CDK50.92417501
50FGFR20.91050787
51PINK10.90158583
52DYRK1A0.88526484
53FER0.88516135
54MET0.87880216
55NTRK10.87661804
56TGFBR10.86104397
57CAMK2B0.84481100
58PRKCH0.83891600
59GRK50.83878236
60BRSK10.83872914
61CCNB10.80297564
62ADRBK10.80074830
63CHEK20.79590472
64CAMK2A0.79370995
65NEK10.76288369
66MKNK10.76011432
67ACVR1B0.73361717
68CSNK1G30.73219723
69STK30.71295904
70FGR0.70912015
71ADRBK20.69749639
72PRKCI0.69509952
73CDK30.68482013
74ALK0.66624522
75CSNK1A1L0.66334731
76WNK40.65272442
77DAPK10.64821908
78WNK30.62942341
79DAPK20.62883958
80CDK140.62797851
81CSNK1E0.62149500
82UHMK10.62063874
83PDK20.60975582
84CSNK1D0.60617468
85STK110.60247292
86PHKG20.59790980
87PHKG10.59790980
88CDK180.59785737
89CDK150.59540807
90PLK40.58653792
91MAP3K120.58452775
92BMPR20.58400113
93TYRO30.58230008
94PRKCZ0.57788430
95MAPK100.57357842
96CAMKK10.56728338
97PLK10.56476946
98GRK10.56220844
99ERBB40.56114593
100ATR0.55899882
101PKN10.55399180
102STK390.53961499
103PRKCE0.53549846
104CSNK1G10.53097806
105CDK11A0.49380063
106CAMK1G0.49144483
107ARAF0.49005339
108BCR0.48907915
109MARK20.48782444
110TAF10.48505772
111MST1R0.48419028
112TTK0.46739495
113BRSK20.46700775
114PRKAA10.46142093
115RAF10.45860321
116PTK2B0.44933091
117MAPK90.42505745
118MAPK150.42307796
119EIF2AK20.41817126
120DYRK30.40946648
121CSNK1A10.39747362
122ABL20.39631462
123STK240.39328918
124SGK10.38438492
125MAP3K20.37858408
126SGK4940.37164825
127SGK2230.37164825
128ATM0.36933498
129BRAF0.36793622
130EPHA30.36174015
131GSK3A0.35791177
132ZAK0.35155457
133CDK10.34919885
134AURKA0.34699106
135CDC70.34131960
136GSK3B0.34068781
137CDK20.33478661

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68976539
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.11413255
3Long-term potentiation_Homo sapiens_hsa047202.64064930
4Amphetamine addiction_Homo sapiens_hsa050312.40748462
5Circadian entrainment_Homo sapiens_hsa047132.15019158
6Glutamatergic synapse_Homo sapiens_hsa047242.11904456
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09954388
8Non-homologous end-joining_Homo sapiens_hsa034502.01013936
9Vitamin B6 metabolism_Homo sapiens_hsa007501.97544816
10Dopaminergic synapse_Homo sapiens_hsa047281.92636101
11Axon guidance_Homo sapiens_hsa043601.88146489
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85232398
13Protein export_Homo sapiens_hsa030601.81957185
14Oocyte meiosis_Homo sapiens_hsa041141.81175378
15Taste transduction_Homo sapiens_hsa047421.76076375
16Synaptic vesicle cycle_Homo sapiens_hsa047211.70637652
17GABAergic synapse_Homo sapiens_hsa047271.69442422
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69327136
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67109818
20Fanconi anemia pathway_Homo sapiens_hsa034601.63233822
21Morphine addiction_Homo sapiens_hsa050321.60569225
22Salivary secretion_Homo sapiens_hsa049701.60292926
23Long-term depression_Homo sapiens_hsa047301.52631088
24Insulin secretion_Homo sapiens_hsa049111.49495066
25Steroid biosynthesis_Homo sapiens_hsa001001.45368643
26Serotonergic synapse_Homo sapiens_hsa047261.41761437
27GnRH signaling pathway_Homo sapiens_hsa049121.41568019
28Gap junction_Homo sapiens_hsa045401.41298434
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40971838
30RNA polymerase_Homo sapiens_hsa030201.40386858
31Glioma_Homo sapiens_hsa052141.38086646
32Cocaine addiction_Homo sapiens_hsa050301.36648029
33Cholinergic synapse_Homo sapiens_hsa047251.35659600
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34580182
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34416717
36Oxytocin signaling pathway_Homo sapiens_hsa049211.33924632
37Olfactory transduction_Homo sapiens_hsa047401.33194053
38Homologous recombination_Homo sapiens_hsa034401.32732828
39Estrogen signaling pathway_Homo sapiens_hsa049151.32095733
40Calcium signaling pathway_Homo sapiens_hsa040201.31293814
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28414815
42Melanogenesis_Homo sapiens_hsa049161.27696081
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27409382
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26363402
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25899145
46Parkinsons disease_Homo sapiens_hsa050121.24857913
47Gastric acid secretion_Homo sapiens_hsa049711.22834138
48Renin secretion_Homo sapiens_hsa049241.22105630
49Regulation of autophagy_Homo sapiens_hsa041401.19279529
50Hedgehog signaling pathway_Homo sapiens_hsa043401.17648895
51mTOR signaling pathway_Homo sapiens_hsa041501.14224798
52ErbB signaling pathway_Homo sapiens_hsa040121.13531548
53RNA transport_Homo sapiens_hsa030131.12984395
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11213975
55Wnt signaling pathway_Homo sapiens_hsa043101.09255760
56ECM-receptor interaction_Homo sapiens_hsa045121.07746506
57Oxidative phosphorylation_Homo sapiens_hsa001901.05965261
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04304618
59Hippo signaling pathway_Homo sapiens_hsa043901.03241760
60Cardiac muscle contraction_Homo sapiens_hsa042601.00848874
61Choline metabolism in cancer_Homo sapiens_hsa052311.00285636
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99550708
63Huntingtons disease_Homo sapiens_hsa050160.97539324
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96477729
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96167751
66Mismatch repair_Homo sapiens_hsa034300.95760437
67Alzheimers disease_Homo sapiens_hsa050100.94995106
68cAMP signaling pathway_Homo sapiens_hsa040240.94605983
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94188214
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93032400
71Type II diabetes mellitus_Homo sapiens_hsa049300.90782538
72Endometrial cancer_Homo sapiens_hsa052130.90012674
73Colorectal cancer_Homo sapiens_hsa052100.88401797
74Lysine degradation_Homo sapiens_hsa003100.86766704
75Dorso-ventral axis formation_Homo sapiens_hsa043200.85613534
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84722462
77Renal cell carcinoma_Homo sapiens_hsa052110.84425408
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83990942
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83206120
80Basal cell carcinoma_Homo sapiens_hsa052170.82674581
81VEGF signaling pathway_Homo sapiens_hsa043700.82052063
82Base excision repair_Homo sapiens_hsa034100.81541296
83mRNA surveillance pathway_Homo sapiens_hsa030150.81524868
84RNA degradation_Homo sapiens_hsa030180.81447308
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81000031
86Cell cycle_Homo sapiens_hsa041100.80943593
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77826835
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76348549
89Tyrosine metabolism_Homo sapiens_hsa003500.75466843
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75423051
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74151049
92Circadian rhythm_Homo sapiens_hsa047100.73725458
93Dilated cardiomyopathy_Homo sapiens_hsa054140.72544399
94Rap1 signaling pathway_Homo sapiens_hsa040150.71371774
95Protein digestion and absorption_Homo sapiens_hsa049740.71080714
96Pathways in cancer_Homo sapiens_hsa052000.70863873
97Butanoate metabolism_Homo sapiens_hsa006500.70353613
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.70095016
99Collecting duct acid secretion_Homo sapiens_hsa049660.69588193
100Nucleotide excision repair_Homo sapiens_hsa034200.69516019
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.69247070
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68490089
103Ras signaling pathway_Homo sapiens_hsa040140.67902539
104MAPK signaling pathway_Homo sapiens_hsa040100.67138810
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.67013432
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66764378
107Propanoate metabolism_Homo sapiens_hsa006400.66210092
108MicroRNAs in cancer_Homo sapiens_hsa052060.64260856
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62394049
110Tight junction_Homo sapiens_hsa045300.62166374
111FoxO signaling pathway_Homo sapiens_hsa040680.60439259
112Phototransduction_Homo sapiens_hsa047440.59024972
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58666452
114Inositol phosphate metabolism_Homo sapiens_hsa005620.58293882
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58121768
116Melanoma_Homo sapiens_hsa052180.57709233
117Basal transcription factors_Homo sapiens_hsa030220.57255747
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55541550
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.55430810
120Adherens junction_Homo sapiens_hsa045200.54999444
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54893164
122Focal adhesion_Homo sapiens_hsa045100.54463057
123Alcoholism_Homo sapiens_hsa050340.54194083
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54110212
125Spliceosome_Homo sapiens_hsa030400.53108571
126Pancreatic secretion_Homo sapiens_hsa049720.52001164
127TGF-beta signaling pathway_Homo sapiens_hsa043500.51840911
128Prostate cancer_Homo sapiens_hsa052150.50343557
129Small cell lung cancer_Homo sapiens_hsa052220.49044998
130Ether lipid metabolism_Homo sapiens_hsa005650.48832633
131p53 signaling pathway_Homo sapiens_hsa041150.48005578
132Proteoglycans in cancer_Homo sapiens_hsa052050.47295543
133Selenocompound metabolism_Homo sapiens_hsa004500.47166535
134Sulfur relay system_Homo sapiens_hsa041220.47081058
135Glucagon signaling pathway_Homo sapiens_hsa049220.46759145
136Non-small cell lung cancer_Homo sapiens_hsa052230.46740162
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46422229
138Thyroid hormone synthesis_Homo sapiens_hsa049180.46321642
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44706773
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.44518141
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39658430

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