GPR162

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.29885187
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.70199347
3locomotory exploration behavior (GO:0035641)6.54909815
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.10349341
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.90679427
6axonemal dynein complex assembly (GO:0070286)5.61150360
7glutamate secretion (GO:0014047)5.54824333
8vocalization behavior (GO:0071625)5.50075331
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.42659964
10synaptic vesicle exocytosis (GO:0016079)5.34907674
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.31755869
12regulation of synaptic vesicle exocytosis (GO:2000300)5.20784950
13regulation of glutamate receptor signaling pathway (GO:1900449)4.96709435
14layer formation in cerebral cortex (GO:0021819)4.89505144
15neurotransmitter secretion (GO:0007269)4.78356136
16cilium or flagellum-dependent cell motility (GO:0001539)4.76045735
17exploration behavior (GO:0035640)4.74878941
18proline transport (GO:0015824)4.68391553
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.65276413
20regulation of neuronal synaptic plasticity (GO:0048168)4.64991857
21regulation of synaptic vesicle transport (GO:1902803)4.64446849
22protein localization to synapse (GO:0035418)4.61229405
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.59609100
24sodium ion export (GO:0071436)4.57443238
25cellular potassium ion homeostasis (GO:0030007)4.45589269
26neuronal action potential propagation (GO:0019227)4.44283488
27gamma-aminobutyric acid transport (GO:0015812)4.43425947
28regulation of synapse structural plasticity (GO:0051823)4.42684082
29dendritic spine morphogenesis (GO:0060997)4.39816277
30synaptic transmission, glutamatergic (GO:0035249)4.28505542
31cilium movement (GO:0003341)4.18235869
32neurotransmitter-gated ion channel clustering (GO:0072578)4.07148765
33motile cilium assembly (GO:0044458)4.06505476
34long-term memory (GO:0007616)4.04755667
35glutamate receptor signaling pathway (GO:0007215)4.01533433
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93438032
37neuromuscular process controlling balance (GO:0050885)3.91920903
38positive regulation of synapse maturation (GO:0090129)3.87817212
39positive regulation of membrane potential (GO:0045838)3.85511883
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84858242
41neurotransmitter transport (GO:0006836)3.83651422
42neuron cell-cell adhesion (GO:0007158)3.79633373
43neuron-neuron synaptic transmission (GO:0007270)3.79566571
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78283446
45activation of protein kinase A activity (GO:0034199)3.75388583
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71070094
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68531475
48glycine transport (GO:0015816)3.65533669
49cerebellar Purkinje cell differentiation (GO:0021702)3.63663255
50cell communication by electrical coupling (GO:0010644)3.63152904
51amino acid import (GO:0043090)3.63040810
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58657327
53regulation of dendritic spine morphogenesis (GO:0061001)3.57012912
54synaptic vesicle endocytosis (GO:0048488)3.55075956
55regulation of synaptic plasticity (GO:0048167)3.53949757
56regulation of neurotransmitter levels (GO:0001505)3.52365486
57regulation of postsynaptic membrane potential (GO:0060078)3.51664383
58regulation of voltage-gated calcium channel activity (GO:1901385)3.51169729
59epithelial cilium movement (GO:0003351)3.50838301
60neuromuscular process controlling posture (GO:0050884)3.50643090
61auditory behavior (GO:0031223)3.48362450
62axon ensheathment in central nervous system (GO:0032291)3.47398099
63central nervous system myelination (GO:0022010)3.47398099
64regulation of neurotransmitter secretion (GO:0046928)3.45847905
65regulation of ARF protein signal transduction (GO:0032012)3.44981534
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42941522
67dendrite morphogenesis (GO:0048813)3.42122645
68presynaptic membrane organization (GO:0097090)3.37697349
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36565268
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35694212
71regulation of synapse maturation (GO:0090128)3.31468843
72transmission of nerve impulse (GO:0019226)3.30854061
73presynaptic membrane assembly (GO:0097105)3.29953975
74response to auditory stimulus (GO:0010996)3.29675345
75cerebellar granule cell differentiation (GO:0021707)3.27144803
76prepulse inhibition (GO:0060134)3.26157663
77L-amino acid import (GO:0043092)3.25393716
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24853451
79potassium ion import (GO:0010107)3.23617723
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23493504
81response to pheromone (GO:0019236)3.19030796
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18181879
83regulation of neurotransmitter transport (GO:0051588)3.17111047
84dendritic spine organization (GO:0097061)3.16961620
85neuronal ion channel clustering (GO:0045161)3.15992607
86neuron recognition (GO:0008038)3.15035151
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.14031422
88regulation of vesicle fusion (GO:0031338)3.13571154
89long-term synaptic potentiation (GO:0060291)3.12003356
90membrane depolarization during action potential (GO:0086010)3.11450468
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10233733
92positive regulation of neurotransmitter secretion (GO:0001956)3.10070229
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09530810
94regulation of clathrin-mediated endocytosis (GO:2000369)3.08381480
95establishment of mitochondrion localization (GO:0051654)3.08206463
96positive regulation of dendritic spine development (GO:0060999)3.07794038
97mechanosensory behavior (GO:0007638)3.07569470
98positive regulation of neurotransmitter transport (GO:0051590)3.07147206
99neuromuscular process (GO:0050905)3.05743448
100vesicle transport along microtubule (GO:0047496)3.05454580
101membrane depolarization (GO:0051899)3.04813115
102cellular sodium ion homeostasis (GO:0006883)3.04768362
103establishment of nucleus localization (GO:0040023)3.04105495
104axonal fasciculation (GO:0007413)3.04084724
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03851825
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02870343
107membrane hyperpolarization (GO:0060081)3.02714706
108potassium ion homeostasis (GO:0055075)2.98688182
109innervation (GO:0060384)2.98135251
110cell migration in hindbrain (GO:0021535)2.96405662
111cerebellar Purkinje cell layer development (GO:0021680)2.95877368
112postsynaptic membrane organization (GO:0001941)2.95267830
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.93386651
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.93223944
115regulation of dendritic spine development (GO:0060998)2.93008871
116regulation of synaptic transmission (GO:0050804)2.92880865
117positive regulation of synaptic transmission (GO:0050806)2.92118006
118adult walking behavior (GO:0007628)2.89039278
119left/right pattern formation (GO:0060972)2.87614592
120pyrimidine nucleobase catabolic process (GO:0006208)2.85388487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54564297
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.02687717
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97719864
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95168413
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89178189
6REST_21632747_ChIP-Seq_MESCs_Mouse2.89012025
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83595452
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83595452
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.81567413
10DROSHA_22980978_ChIP-Seq_HELA_Human2.81123984
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.67128316
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.66561138
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62495110
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54675137
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53761859
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.46431337
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40899514
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36083496
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35987428
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.32553676
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.31189470
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30986018
23GBX2_23144817_ChIP-Seq_PC3_Human2.29830229
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.27242478
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20665056
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.05185960
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00365930
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.98623152
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96184671
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94745570
31KDM2B_26808549_Chip-Seq_K562_Human1.79205160
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77479219
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.66327725
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60810298
35* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60553447
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55093939
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54598742
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.49508503
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47966372
40AR_21572438_ChIP-Seq_LNCaP_Human1.43021836
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40476127
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39962026
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.35056247
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34824346
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34157212
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33186529
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28801650
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26849147
49AR_19668381_ChIP-Seq_PC3_Human1.26557461
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23885337
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22752151
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22221684
53* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19297795
54SMAD4_21799915_ChIP-Seq_A2780_Human1.18202316
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16931717
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.16596138
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16460466
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.16147798
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16143512
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.14869834
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14142160
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.08494947
63SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08011419
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07277515
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07210569
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05801942
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05487527
68LXR_22292898_ChIP-Seq_THP-1_Human1.05352755
69* SMC4_20622854_ChIP-Seq_HELA_Human1.03930229
70TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02623258
71CTCF_27219007_Chip-Seq_Bcells_Human1.01944724
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01912741
73* P68_20966046_ChIP-Seq_HELA_Human0.99990392
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99375943
75KDM2B_26808549_Chip-Seq_JURKAT_Human0.98350237
76STAT3_23295773_ChIP-Seq_U87_Human0.97163185
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97000846
78SMAD3_21741376_ChIP-Seq_HESCs_Human0.96995383
79ZNF274_21170338_ChIP-Seq_K562_Hela0.96845996
80* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96035260
81* KDM2B_26808549_Chip-Seq_DND41_Human0.95947994
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95510569
83NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95342183
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95036093
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94413504
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94382999
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.92463767
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92364331
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.92209308
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91793418
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89185402
92AHR_22903824_ChIP-Seq_MCF-7_Human0.88448189
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.88380893
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88089234
95KLF4_19829295_ChIP-Seq_ESCs_Human0.87278813
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.86983481
97* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86589675
98AR_25329375_ChIP-Seq_VCAP_Human0.84902394
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.84857646
100* OCT4_19829295_ChIP-Seq_ESCs_Human0.84616788
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84574856
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83665535
103RXR_22108803_ChIP-Seq_LS180_Human0.83524874
104* SMAD4_21741376_ChIP-Seq_ESCs_Human0.83287700
105DPY_21335234_ChIP-Seq_ESCs_Mouse0.81671249
106SA1_27219007_Chip-Seq_ERYTHROID_Human0.81220564
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80009561
108RNF2_27304074_Chip-Seq_NSC_Mouse0.79974439
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79839700
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79299770
111CREB1_26743006_Chip-Seq_LNCaP_Human0.77170911
112TCF4_23295773_ChIP-Seq_U87_Human0.76999011
113* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76779668
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76490079
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75796455
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.75729873
117ELK4_26923725_Chip-Seq_MESODERM_Mouse0.74005693
118TP63_22573176_ChIP-Seq_HFKS_Human0.73606335
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.72702695
120* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72540127
121* CTCF_20526341_ChIP-Seq_ESCs_Human0.72390061
122SA1_27219007_Chip-Seq_Bcells_Human0.72106016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.29997267
2MP0003635_abnormal_synaptic_transmissio4.32763661
3MP0003880_abnormal_central_pattern4.07556500
4MP0004270_analgesia3.81143894
5MP0002063_abnormal_learning/memory/cond3.37428041
6MP0009745_abnormal_behavioral_response3.34698043
7MP0009046_muscle_twitch3.32571599
8MP0002064_seizures3.21206590
9MP0005423_abnormal_somatic_nervous3.11358004
10MP0002572_abnormal_emotion/affect_behav2.73569834
11MP0002734_abnormal_mechanical_nocicepti2.62741034
12MP0001486_abnormal_startle_reflex2.61658586
13MP0001968_abnormal_touch/_nociception2.61474825
14MP0004858_abnormal_nervous_system2.57852509
15MP0002822_catalepsy2.54113003
16MP0002272_abnormal_nervous_system2.53218505
17MP0008569_lethality_at_weaning2.22742001
18MP0001501_abnormal_sleep_pattern2.21745882
19MP0002733_abnormal_thermal_nociception1.94879040
20MP0001440_abnormal_grooming_behavior1.94767222
21MP0009780_abnormal_chondrocyte_physiolo1.93954640
22MP0004811_abnormal_neuron_physiology1.90844057
23MP0002909_abnormal_adrenal_gland1.90643469
24MP0001970_abnormal_pain_threshold1.86419303
25MP0003329_amyloid_beta_deposits1.85774603
26MP0002067_abnormal_sensory_capabilities1.84307413
27MP0004885_abnormal_endolymph1.83995945
28MP0002184_abnormal_innervation1.83146656
29MP0002736_abnormal_nociception_after1.78134113
30MP0000778_abnormal_nervous_system1.75598924
31MP0000955_abnormal_spinal_cord1.72117077
32MP0002557_abnormal_social/conspecific_i1.70812358
33MP0002735_abnormal_chemical_nociception1.69877548
34MP0003787_abnormal_imprinting1.59159701
35MP0005386_behavior/neurological_phenoty1.57078045
36MP0004924_abnormal_behavior1.57078045
37MP0002882_abnormal_neuron_morphology1.50872606
38MP0003283_abnormal_digestive_organ1.50040103
39MP0003879_abnormal_hair_cell1.48602113
40MP0002066_abnormal_motor_capabilities/c1.43899420
41MP0003633_abnormal_nervous_system1.43827696
42MP0008961_abnormal_basal_metabolism1.43727577
43MP0003122_maternal_imprinting1.40207295
44MP0005394_taste/olfaction_phenotype1.33928104
45MP0005499_abnormal_olfactory_system1.33928104
46MP0001984_abnormal_olfaction1.29791941
47MP0000569_abnormal_digit_pigmentation1.26736927
48MP0001502_abnormal_circadian_rhythm1.23361567
49MP0005646_abnormal_pituitary_gland1.21564042
50MP0004142_abnormal_muscle_tone1.18850844
51MP0003631_nervous_system_phenotype1.18202093
52MP0002152_abnormal_brain_morphology1.17908181
53MP0003075_altered_response_to1.15841288
54MP0005551_abnormal_eye_electrophysiolog1.15757199
55MP0001188_hyperpigmentation1.13103103
56MP0004133_heterotaxia1.09177856
57MP0002229_neurodegeneration1.08696912
58MP0001529_abnormal_vocalization1.07238356
59MP0005645_abnormal_hypothalamus_physiol1.06857336
60MP0008872_abnormal_physiological_respon1.05829460
61MP0003690_abnormal_glial_cell1.05515187
62MP0001485_abnormal_pinna_reflex1.04655244
63MP0002638_abnormal_pupillary_reflex1.02811025
64MP0004145_abnormal_muscle_electrophysio1.00404738
65MP0003632_abnormal_nervous_system0.97967470
66MP0005167_abnormal_blood-brain_barrier0.97432924
67MP0002249_abnormal_larynx_morphology0.95915980
68MP0003634_abnormal_glial_cell0.95771767
69MP0002069_abnormal_eating/drinking_beha0.93731371
70MP0008789_abnormal_olfactory_epithelium0.92799283
71MP0006276_abnormal_autonomic_nervous0.91652477
72MP0002653_abnormal_ependyma_morphology0.91056763
73MP0003172_abnormal_lysosome_physiology0.90514995
74MP0001346_abnormal_lacrimal_gland0.89973474
75MP0008874_decreased_physiological_sensi0.89585034
76MP0001177_atelectasis0.89017712
77MP0001986_abnormal_taste_sensitivity0.87225604
78MP0000920_abnormal_myelination0.85489068
79MP0005623_abnormal_meninges_morphology0.85450389
80MP0002090_abnormal_vision0.85076344
81MP0003137_abnormal_impulse_conducting0.84815387
82MP0000751_myopathy0.81521125
83MP0004085_abnormal_heartbeat0.81469048
84MP0002752_abnormal_somatic_nervous0.81179184
85MP0000604_amyloidosis0.80851408
86MP0003121_genomic_imprinting0.79479304
87MP0000026_abnormal_inner_ear0.79271603
88MP0005409_darkened_coat_color0.78962009
89MP0001905_abnormal_dopamine_level0.77573790
90MP0010234_abnormal_vibrissa_follicle0.76819116
91MP0009379_abnormal_foot_pigmentation0.76804676
92MP0004043_abnormal_pH_regulation0.74659701
93MP0005535_abnormal_body_temperature0.71027730
94MP0003878_abnormal_ear_physiology0.70023442
95MP0005377_hearing/vestibular/ear_phenot0.70023442
96MP0001963_abnormal_hearing_physiology0.69550904
97MP0008875_abnormal_xenobiotic_pharmacok0.69322558
98MP0006072_abnormal_retinal_apoptosis0.68382748
99MP0008877_abnormal_DNA_methylation0.67605117
100MP0001348_abnormal_lacrimal_gland0.67481385
101MP0003861_abnormal_nervous_system0.67203852
102MP0003938_abnormal_ear_development0.66916448
103MP0000631_abnormal_neuroendocrine_gland0.66468979
104MP0004742_abnormal_vestibular_system0.66379375
105MP0005253_abnormal_eye_physiology0.64854946
106MP0004130_abnormal_muscle_cell0.64052909
107MP0000013_abnormal_adipose_tissue0.63410076
108MP0004510_myositis0.62159523
109MP0006292_abnormal_olfactory_placode0.61950384
110MP0002089_abnormal_postnatal_growth/wei0.60814358
111MP0010769_abnormal_survival0.59778909
112MP0004233_abnormal_muscle_weight0.59482287
113MP0004215_abnormal_myocardial_fiber0.57730157
114MP0010768_mortality/aging0.55718712
115MP0001943_abnormal_respiration0.55126410
116MP0003123_paternal_imprinting0.54129164
117MP0010770_preweaning_lethality0.53665852
118MP0002082_postnatal_lethality0.53665852
119MP0003956_abnormal_body_size0.51815931
120MP0000681_abnormal_thyroid_gland0.49710960
121MP0000639_abnormal_adrenal_gland0.49698371
122MP0003303_peritoneal_inflammation0.49335964

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.80577728
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.65327706
3Focal motor seizures (HP:0011153)6.22406543
4Abnormal respiratory epithelium morphology (HP:0012253)6.03309198
5Abnormal respiratory motile cilium morphology (HP:0005938)6.03309198
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.98131407
7Absent/shortened dynein arms (HP:0200106)5.98131407
8Abnormal respiratory motile cilium physiology (HP:0012261)5.81211274
9Abnormal ciliary motility (HP:0012262)5.79660819
10Visual hallucinations (HP:0002367)5.48950963
11Focal seizures (HP:0007359)5.35945746
12Rhinitis (HP:0012384)5.11394636
13Abnormality of the lower motor neuron (HP:0002366)4.45731270
14Action tremor (HP:0002345)4.42919507
15Epileptic encephalopathy (HP:0200134)4.28998868
16Progressive cerebellar ataxia (HP:0002073)4.22467198
17Febrile seizures (HP:0002373)4.04610504
18Supranuclear gaze palsy (HP:0000605)3.91076949
19Atonic seizures (HP:0010819)3.88515109
20Chronic bronchitis (HP:0004469)3.63534550
21Ankle clonus (HP:0011448)3.61831983
22Absence seizures (HP:0002121)3.59714936
23Generalized tonic-clonic seizures (HP:0002069)3.50411819
24Nasal polyposis (HP:0100582)3.50019413
25Depression (HP:0000716)3.43079558
26Dialeptic seizures (HP:0011146)3.35955269
27Bronchiectasis (HP:0002110)3.35387561
28Dysdiadochokinesis (HP:0002075)3.33332374
29Mutism (HP:0002300)3.31504885
30Poor eye contact (HP:0000817)3.27186363
31Postural instability (HP:0002172)3.15728128
32Impaired vibration sensation in the lower limbs (HP:0002166)3.14515780
33Gaze-evoked nystagmus (HP:0000640)3.13325220
34Papilledema (HP:0001085)3.06951568
35Hemiparesis (HP:0001269)3.06067462
36Impaired social interactions (HP:0000735)3.03775466
37Abnormal social behavior (HP:0012433)3.03775466
38Broad-based gait (HP:0002136)3.00298463
39Urinary bladder sphincter dysfunction (HP:0002839)2.99915141
40Intention tremor (HP:0002080)2.99593884
41Hemiplegia (HP:0002301)2.99582770
42Dysmetria (HP:0001310)2.99522340
43Genetic anticipation (HP:0003743)2.93446504
44Abnormality of the nasal mucosa (HP:0000433)2.92844758
45Limb dystonia (HP:0002451)2.86057603
46Polyphagia (HP:0002591)2.85955572
47Sleep apnea (HP:0010535)2.82406998
48Amblyopia (HP:0000646)2.82222717
49Impaired smooth pursuit (HP:0007772)2.80815408
50Annular pancreas (HP:0001734)2.78580701
51Amyotrophic lateral sclerosis (HP:0007354)2.78048133
52Ventricular fibrillation (HP:0001663)2.74949422
53Truncal ataxia (HP:0002078)2.71223888
54Abnormal eating behavior (HP:0100738)2.70399610
55Abnormality of ocular smooth pursuit (HP:0000617)2.69140218
56Anxiety (HP:0000739)2.68937134
57Insomnia (HP:0100785)2.61442037
58Diplopia (HP:0000651)2.60571868
59Abnormality of binocular vision (HP:0011514)2.60571868
60Urinary urgency (HP:0000012)2.59478909
61Spastic gait (HP:0002064)2.57426701
62Torticollis (HP:0000473)2.56573709
63Status epilepticus (HP:0002133)2.52565330
64Tetraplegia (HP:0002445)2.50663640
65Bradykinesia (HP:0002067)2.47086843
66Dysmetric saccades (HP:0000641)2.45410906
67Megalencephaly (HP:0001355)2.44543076
68Pointed chin (HP:0000307)2.44483516
69Infertility (HP:0000789)2.42686552
70Scanning speech (HP:0002168)2.40808680
71Hyperventilation (HP:0002883)2.40736468
72Abnormality of the corticospinal tract (HP:0002492)2.40156085
73Drooling (HP:0002307)2.37461523
74Excessive salivation (HP:0003781)2.37461523
75Stereotypic behavior (HP:0000733)2.34040736
76Focal dystonia (HP:0004373)2.32686583
77Akinesia (HP:0002304)2.30637616
78Neurofibrillary tangles (HP:0002185)2.29471145
79Apathy (HP:0000741)2.25918928
80Neuronal loss in central nervous system (HP:0002529)2.24163768
81Impaired vibratory sensation (HP:0002495)2.21621825
82Bundle branch block (HP:0011710)2.20651147
83Peripheral hypomyelination (HP:0007182)2.20516597
84Cerebral inclusion bodies (HP:0100314)2.19972129
85Lower limb muscle weakness (HP:0007340)2.19693780
86Neoplasm of the heart (HP:0100544)2.15073909
87Gait imbalance (HP:0002141)2.12542741
88Horizontal nystagmus (HP:0000666)2.12215710
89Atelectasis (HP:0100750)2.11351848
90Clonus (HP:0002169)2.07739228
91Resting tremor (HP:0002322)2.07365344
92Fetal akinesia sequence (HP:0001989)2.04496891
93Delusions (HP:0000746)2.02516874
94Craniofacial dystonia (HP:0012179)2.02337429
95Recurrent sinusitis (HP:0011108)2.01047655
96Generalized myoclonic seizures (HP:0002123)2.00806676
97Hand muscle atrophy (HP:0009130)1.98848357
98Generalized hypotonia (HP:0001290)1.98630999
99Diminished motivation (HP:0000745)1.98059014
100Progressive inability to walk (HP:0002505)1.97957445
101Recurrent otitis media (HP:0000403)1.97581005
102Cerebral hypomyelination (HP:0006808)1.97022705
103Ankyloglossia (HP:0010296)1.95726564
104Agitation (HP:0000713)1.95531528
105Macroorchidism (HP:0000053)1.94715156
106Rapidly progressive (HP:0003678)1.94194105
107Obstructive sleep apnea (HP:0002870)1.93958257
108Spastic tetraparesis (HP:0001285)1.91870323
109Occipital encephalocele (HP:0002085)1.90904210
110Inappropriate behavior (HP:0000719)1.90545708
111Intellectual disability, profound (HP:0002187)1.88327749
112Male infertility (HP:0003251)1.88258335
113Hepatoblastoma (HP:0002884)1.88172059
114Absent speech (HP:0001344)1.87408467
115Hyperacusis (HP:0010780)1.86891849
116Abnormality of saccadic eye movements (HP:0000570)1.85249358
117Distal upper limb amyotrophy (HP:0007149)1.83263785
118Upper limb amyotrophy (HP:0009129)1.83263785
119Achilles tendon contracture (HP:0001771)1.82200171
120Abnormal EKG (HP:0003115)1.81929904
121Gait ataxia (HP:0002066)1.81347519
122Epileptiform EEG discharges (HP:0011182)1.81000889
123EEG with generalized epileptiform discharges (HP:0011198)1.80747963
124Abnormality of the periventricular white matter (HP:0002518)1.79245673
125CNS hypomyelination (HP:0003429)1.78664184
126Hypsarrhythmia (HP:0002521)1.78045973
127Rigidity (HP:0002063)1.78036805
128Incomplete penetrance (HP:0003829)1.78031827
129Termporal pattern (HP:0011008)1.76313007
130Lower limb asymmetry (HP:0100559)1.75156546
131Chronic sinusitis (HP:0011109)1.75066689
132Failure to thrive in infancy (HP:0001531)1.75031264
133Morphological abnormality of the pyramidal tract (HP:0002062)1.70138622
134Aplasia involving bones of the upper limbs (HP:0009823)1.63313795
135Aplasia of the phalanges of the hand (HP:0009802)1.63313795
136Aplasia involving bones of the extremities (HP:0009825)1.63313795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.24895275
2NTRK33.95664068
3EPHA43.71486154
4MARK13.19698941
5DAPK22.70274603
6PAK62.62802389
7MINK12.60431191
8PRKD32.59723413
9MAP3K42.59609278
10MAPK152.30201344
11CAMKK12.29355817
12NTRK22.27462545
13GRK52.20675300
14KSR22.16733847
15CASK2.10611672
16NTRK12.08535767
17TYRO32.02071841
18MAP2K41.86484612
19STK381.82981227
20MAP2K71.79866202
21SIK21.56690613
22CDK51.53487251
23KSR11.46209544
24TAOK11.44586042
25RIPK11.43934995
26ALK1.37822726
27DAPK11.34039923
28RIPK41.33912806
29PRPF4B1.31217154
30PRKCG1.18144581
31CDK191.16360766
32UHMK11.14840086
33CAMKK21.12537230
34PHKG11.12520305
35PHKG21.12520305
36LATS21.12447214
37PRKCH1.12173002
38CAMK11.05781135
39MAP3K21.04942689
40STK111.04308745
41MARK21.03067144
42MAP3K130.99074688
43PLK20.98899962
44CDK150.98517739
45FES0.98350324
46ARAF0.96086932
47CDK180.96003594
48MAP3K110.95797215
49PINK10.95540067
50WNK10.95177210
51MAPK130.92264885
52TNIK0.91253022
53MAP3K120.91214229
54RET0.89035389
55CDK140.86693863
56LMTK20.86539443
57CDK11A0.86422607
58CAMK40.85728015
59NEK60.84876488
60NEK10.81789119
61NME10.80424488
62SGK2230.79652843
63SGK4940.79652843
64PKN10.76605458
65MAP3K70.75378729
66PAK30.73839228
67SGK30.73670767
68DYRK1B0.73617679
69PDK10.72353630
70DYRK1A0.69756849
71CAMK2G0.67394032
72PNCK0.66515794
73DYRK20.66474762
74CAMK2A0.65593032
75CDC42BPA0.62645867
76BCR0.62122469
77CAMK1G0.61759220
78TRIB30.61552939
79RAF10.60498736
80ICK0.59892257
81SGK10.59509535
82TNK20.59476777
83BRSK10.58429499
84PDPK10.57134764
85SCYL20.57067950
86RPS6KA30.56814707
87SGK20.56327599
88MAPK100.52688752
89CSNK1G20.51556080
90PDGFRA0.50874723
91GRK60.50797055
92FYN0.50150956
93PRKCZ0.49804461
94RPS6KA20.48832523
95DDR20.48810199
96BRAF0.48315873
97CDK120.47642041
98MAP3K10.47610611
99ROCK20.46231493
100TAOK20.44706954
101PTK2B0.42896435
102MOS0.42675272
103MAPK70.42329625
104LIMK10.42306933
105CAMK2B0.41325476
106TESK10.39895816
107MAPK120.39354036
108BMX0.38971277
109DAPK30.36114625
110ERBB20.35613910
111JAK20.34914327
112OXSR10.34160067
113MAP2K60.33979758
114CSK0.33215955
115HIPK20.32810047
116SRC0.32150147
117MAPK80.31458768
118PRKCA0.31034507
119MATK0.30871306
120PRKD20.29017102

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.21849603
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16407433
3Olfactory transduction_Homo sapiens_hsa047402.73051822
4GABAergic synapse_Homo sapiens_hsa047272.65569719
5Glutamatergic synapse_Homo sapiens_hsa047242.59939189
6Circadian entrainment_Homo sapiens_hsa047132.58147199
7Long-term potentiation_Homo sapiens_hsa047202.52917049
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48554436
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35033987
10Morphine addiction_Homo sapiens_hsa050322.28036871
11Amphetamine addiction_Homo sapiens_hsa050312.17262120
12Salivary secretion_Homo sapiens_hsa049702.11446678
13Dopaminergic synapse_Homo sapiens_hsa047281.98780517
14Gastric acid secretion_Homo sapiens_hsa049711.91157738
15Insulin secretion_Homo sapiens_hsa049111.90869340
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84019231
17Cholinergic synapse_Homo sapiens_hsa047251.82846020
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77763919
19Nitrogen metabolism_Homo sapiens_hsa009101.76963868
20Long-term depression_Homo sapiens_hsa047301.63195945
21Oxytocin signaling pathway_Homo sapiens_hsa049211.62557565
22Taste transduction_Homo sapiens_hsa047421.53675104
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51301602
24GnRH signaling pathway_Homo sapiens_hsa049121.49447787
25Renin secretion_Homo sapiens_hsa049241.46866675
26Calcium signaling pathway_Homo sapiens_hsa040201.46328697
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45446162
28Cocaine addiction_Homo sapiens_hsa050301.45340333
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43677151
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36393721
31Serotonergic synapse_Homo sapiens_hsa047261.33472330
32Gap junction_Homo sapiens_hsa045401.30120653
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29732543
34cAMP signaling pathway_Homo sapiens_hsa040241.29705802
35Type II diabetes mellitus_Homo sapiens_hsa049301.29626570
36Glioma_Homo sapiens_hsa052141.22514030
37Estrogen signaling pathway_Homo sapiens_hsa049151.18491370
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10748017
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10221613
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.08299423
41ErbB signaling pathway_Homo sapiens_hsa040121.03655213
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01998480
43Axon guidance_Homo sapiens_hsa043601.01118264
44Melanogenesis_Homo sapiens_hsa049160.99865168
45Phototransduction_Homo sapiens_hsa047440.94085183
46Dorso-ventral axis formation_Homo sapiens_hsa043200.89434910
47mTOR signaling pathway_Homo sapiens_hsa041500.89289428
48Oocyte meiosis_Homo sapiens_hsa041140.88662783
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.86266835
50Choline metabolism in cancer_Homo sapiens_hsa052310.83130236
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82316459
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82269008
53Histidine metabolism_Homo sapiens_hsa003400.81492187
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80269330
55Thyroid hormone synthesis_Homo sapiens_hsa049180.79644125
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79401444
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.79294116
58Pancreatic secretion_Homo sapiens_hsa049720.79059738
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78596686
60Dilated cardiomyopathy_Homo sapiens_hsa054140.77492439
61Collecting duct acid secretion_Homo sapiens_hsa049660.77160508
62VEGF signaling pathway_Homo sapiens_hsa043700.76550897
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75761169
64Cardiac muscle contraction_Homo sapiens_hsa042600.73381633
65Bile secretion_Homo sapiens_hsa049760.72708100
66MAPK signaling pathway_Homo sapiens_hsa040100.72693013
67Vitamin B6 metabolism_Homo sapiens_hsa007500.70226691
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66927161
69Inositol phosphate metabolism_Homo sapiens_hsa005620.65991607
70Endocytosis_Homo sapiens_hsa041440.63905658
71Non-small cell lung cancer_Homo sapiens_hsa052230.63878038
72Rap1 signaling pathway_Homo sapiens_hsa040150.63451002
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63036463
74Endometrial cancer_Homo sapiens_hsa052130.62695411
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.59739387
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58721602
77Ras signaling pathway_Homo sapiens_hsa040140.56005839
78beta-Alanine metabolism_Homo sapiens_hsa004100.55213599
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54803178
80Glucagon signaling pathway_Homo sapiens_hsa049220.52441289
81Phenylalanine metabolism_Homo sapiens_hsa003600.52021336
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50765352
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49963860
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48245588
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48097773
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47886577
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47341078
88Renal cell carcinoma_Homo sapiens_hsa052110.45548819
89Vibrio cholerae infection_Homo sapiens_hsa051100.45093895
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44929445
91Alcoholism_Homo sapiens_hsa050340.44326297
92Ovarian steroidogenesis_Homo sapiens_hsa049130.44106086
93Insulin signaling pathway_Homo sapiens_hsa049100.44047808
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43571698
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.42724565
96Wnt signaling pathway_Homo sapiens_hsa043100.41798390
97Chemokine signaling pathway_Homo sapiens_hsa040620.41410495
98Notch signaling pathway_Homo sapiens_hsa043300.41145357
99Prion diseases_Homo sapiens_hsa050200.38807778
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38234852
101Colorectal cancer_Homo sapiens_hsa052100.36608378
102Regulation of autophagy_Homo sapiens_hsa041400.36328930
103Type I diabetes mellitus_Homo sapiens_hsa049400.36081039
104Phagosome_Homo sapiens_hsa041450.35309078
105Circadian rhythm_Homo sapiens_hsa047100.35043783
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34338733
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33633079
108Tight junction_Homo sapiens_hsa045300.33351579
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32889192
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.30434116
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30308032
112Salmonella infection_Homo sapiens_hsa051320.30249685
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30002439
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29519279
115Hedgehog signaling pathway_Homo sapiens_hsa043400.27436242
116Hippo signaling pathway_Homo sapiens_hsa043900.25963311
117Huntingtons disease_Homo sapiens_hsa050160.25459205

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