

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 7.43370894 |
| 2 | neuron cell-cell adhesion (GO:0007158) | 7.04096631 |
| 3 | amino acid import (GO:0043090) | 5.90721915 |
| 4 | activated T cell proliferation (GO:0050798) | 5.83357213 |
| 5 | L-amino acid import (GO:0043092) | 5.18566476 |
| 6 | central nervous system myelination (GO:0022010) | 5.16333791 |
| 7 | axon ensheathment in central nervous system (GO:0032291) | 5.16333791 |
| 8 | oligodendrocyte differentiation (GO:0048709) | 4.86365592 |
| 9 | presynaptic membrane assembly (GO:0097105) | 4.85152241 |
| 10 | myelination (GO:0042552) | 4.73048212 |
| 11 | dermatan sulfate biosynthetic process (GO:0030208) | 4.62263942 |
| 12 | ensheathment of neurons (GO:0007272) | 4.61685864 |
| 13 | axon ensheathment (GO:0008366) | 4.61685864 |
| 14 | exploration behavior (GO:0035640) | 4.54400808 |
| 15 | positive regulation of osteoblast proliferation (GO:0033690) | 4.50102689 |
| 16 | postsynaptic membrane organization (GO:0001941) | 4.31498421 |
| 17 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 4.28056114 |
| 18 | dendrite morphogenesis (GO:0048813) | 4.26303675 |
| 19 | dermatan sulfate metabolic process (GO:0030205) | 4.21687773 |
| 20 | presynaptic membrane organization (GO:0097090) | 4.20801779 |
| 21 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 4.14465226 |
| 22 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.14065219 |
| 23 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.03828752 |
| 24 | astrocyte differentiation (GO:0048708) | 4.02552573 |
| 25 | auditory behavior (GO:0031223) | 3.99698868 |
| 26 | chondroitin sulfate catabolic process (GO:0030207) | 3.91344267 |
| 27 | eye photoreceptor cell differentiation (GO:0001754) | 3.89412983 |
| 28 | photoreceptor cell differentiation (GO:0046530) | 3.89412983 |
| 29 | negative regulation of axon extension (GO:0030517) | 3.86527543 |
| 30 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.83150951 |
| 31 | nephron tubule formation (GO:0072079) | 3.81467212 |
| 32 | positive regulation of neurological system process (GO:0031646) | 3.74537372 |
| 33 | transmission of nerve impulse (GO:0019226) | 3.74498365 |
| 34 | dendritic spine morphogenesis (GO:0060997) | 3.71331230 |
| 35 | peripheral nervous system axon ensheathment (GO:0032292) | 3.69056443 |
| 36 | myelination in peripheral nervous system (GO:0022011) | 3.69056443 |
| 37 | cellular response to epinephrine stimulus (GO:0071872) | 3.68106075 |
| 38 | response to methylmercury (GO:0051597) | 3.64907412 |
| 39 | potassium ion import (GO:0010107) | 3.64536603 |
| 40 | regulation of transmission of nerve impulse (GO:0051969) | 3.63089121 |
| 41 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.60640487 |
| 42 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.57698823 |
| 43 | chondroitin sulfate biosynthetic process (GO:0030206) | 3.53607980 |
| 44 | vocalization behavior (GO:0071625) | 3.51636242 |
| 45 | mechanosensory behavior (GO:0007638) | 3.48195344 |
| 46 | cellular potassium ion homeostasis (GO:0030007) | 3.46531344 |
| 47 | enteric nervous system development (GO:0048484) | 3.44097825 |
| 48 | potassium ion homeostasis (GO:0055075) | 3.43343254 |
| 49 | response to epinephrine (GO:0071871) | 3.41681030 |
| 50 | C4-dicarboxylate transport (GO:0015740) | 3.41628377 |
| 51 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 3.38387269 |
| 52 | negative regulation of synaptic transmission (GO:0050805) | 3.35793074 |
| 53 | neuron recognition (GO:0008038) | 3.33612691 |
| 54 | cerebellar granule cell differentiation (GO:0021707) | 3.33413837 |
| 55 | negative regulation of axonogenesis (GO:0050771) | 3.32615591 |
| 56 | negative regulation of neurotransmitter transport (GO:0051589) | 3.32185002 |
| 57 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.29223115 |
| 58 | sodium ion export (GO:0071436) | 3.25892401 |
| 59 | protein localization to synapse (GO:0035418) | 3.25718303 |
| 60 | negative regulation of protein localization to cell surface (GO:2000009) | 3.25381408 |
| 61 | neurotransmitter uptake (GO:0001504) | 3.24475450 |
| 62 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.23446262 |
| 63 | regulation of synapse maturation (GO:0090128) | 3.20181156 |
| 64 | substantia nigra development (GO:0021762) | 3.19541770 |
| 65 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.19287230 |
| 66 | neuronal ion channel clustering (GO:0045161) | 3.18272297 |
| 67 | long-term synaptic potentiation (GO:0060291) | 3.17871052 |
| 68 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.16921687 |
| 69 | regulation of neuron projection regeneration (GO:0070570) | 3.15871332 |
| 70 | regulation of axon regeneration (GO:0048679) | 3.15871332 |
| 71 | synaptic vesicle maturation (GO:0016188) | 3.14544973 |
| 72 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.14095253 |
| 73 | glial cell differentiation (GO:0010001) | 3.09202552 |
| 74 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.08382149 |
| 75 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.07530947 |
| 76 | synaptic transmission, glutamatergic (GO:0035249) | 3.04772336 |
| 77 | peripheral nervous system development (GO:0007422) | 3.03686967 |
| 78 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.03376844 |
| 79 | neuron projection regeneration (GO:0031102) | 3.02828228 |
| 80 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.00822690 |
| 81 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.00777270 |
| 82 | response to auditory stimulus (GO:0010996) | 3.00282023 |
| 83 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.94894369 |
| 84 | negative regulation of myoblast differentiation (GO:0045662) | 2.94641033 |
| 85 | layer formation in cerebral cortex (GO:0021819) | 2.93510773 |
| 86 | glutamate receptor signaling pathway (GO:0007215) | 2.93347139 |
| 87 | fatty acid elongation (GO:0030497) | 2.92404572 |
| 88 | membrane hyperpolarization (GO:0060081) | 2.90340311 |
| 89 | respiratory tube development (GO:0030323) | 2.89540096 |
| 90 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.89063789 |
| 91 | regulation of synapse structural plasticity (GO:0051823) | 2.87527201 |
| 92 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.86340569 |
| 93 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.85875178 |
| 94 | Sertoli cell development (GO:0060009) | 2.85465376 |
| 95 | oligosaccharide catabolic process (GO:0009313) | 2.84158613 |
| 96 | gamma-aminobutyric acid transport (GO:0015812) | 2.83249417 |
| 97 | cGMP-mediated signaling (GO:0019934) | 2.83015744 |
| 98 | regulation of cardiac muscle cell contraction (GO:0086004) | 2.82371121 |
| 99 | neuromuscular process controlling balance (GO:0050885) | 2.82013431 |
| 100 | regulation of oligodendrocyte differentiation (GO:0048713) | 2.81276464 |
| 101 | positive regulation of synapse assembly (GO:0051965) | 2.80193774 |
| 102 | neuronal action potential propagation (GO:0019227) | 2.79567193 |
| 103 | astrocyte development (GO:0014002) | 2.79263280 |
| 104 | regulation of collateral sprouting (GO:0048670) | 2.79257147 |
| 105 | glycosphingolipid catabolic process (GO:0046479) | 2.78583663 |
| 106 | regulation of axon extension (GO:0030516) | 2.78097091 |
| 107 | regulation of extent of cell growth (GO:0061387) | 2.78077827 |
| 108 | positive regulation of gliogenesis (GO:0014015) | 2.77686288 |
| 109 | synapse organization (GO:0050808) | 2.77144830 |
| 110 | import into cell (GO:0098657) | 2.76738390 |
| 111 | membrane assembly (GO:0071709) | 2.73992210 |
| 112 | prepulse inhibition (GO:0060134) | 2.73772576 |
| 113 | positive regulation of membrane potential (GO:0045838) | 2.73638923 |
| 114 | axonal fasciculation (GO:0007413) | 2.72685213 |
| 115 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.72646898 |
| 116 | cell communication by electrical coupling (GO:0010644) | 2.71405849 |
| 117 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.69567314 |
| 118 | spinal cord motor neuron differentiation (GO:0021522) | 2.68754579 |
| 119 | regulation of respiratory system process (GO:0044065) | 2.68499517 |
| 120 | regulation of axon guidance (GO:1902667) | 2.68072424 |
| 121 | neurotransmitter catabolic process (GO:0042135) | 2.66399390 |
| 122 | long-chain fatty acid biosynthetic process (GO:0042759) | 2.66024906 |
| 123 | detection of mechanical stimulus involved in sensory perception (GO:0050974) | 2.65929663 |
| 124 | positive regulation of synapse maturation (GO:0090129) | 2.65103156 |
| 125 | adult walking behavior (GO:0007628) | 2.64924026 |
| 126 | acidic amino acid transport (GO:0015800) | 2.64781790 |
| 127 | synapse assembly (GO:0007416) | 2.63955406 |
| 128 | neuromuscular process (GO:0050905) | 2.61938933 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.27240153 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.44724707 |
| 3 | AR_21572438_ChIP-Seq_LNCaP_Human | 3.14751520 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.89803476 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.89135208 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.87821517 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.54327692 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.54327692 |
| 9 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.49066033 |
| 10 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.48862412 |
| 11 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.47286508 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.45738026 |
| 13 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.41237453 |
| 14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.39054109 |
| 15 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 2.36415088 |
| 16 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.34259009 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.32371445 |
| 18 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.24874131 |
| 19 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.24659436 |
| 20 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.15416976 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.14578760 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.10339970 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.07381556 |
| 24 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.00397201 |
| 25 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.91646860 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.89926841 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.84118705 |
| 28 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.82739551 |
| 29 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.79276705 |
| 30 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.76631470 |
| 31 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.76249216 |
| 32 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.75526402 |
| 33 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.71848113 |
| 34 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.67663884 |
| 35 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.65861062 |
| 36 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.63384078 |
| 37 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.61474892 |
| 38 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.59168493 |
| 39 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.56533452 |
| 40 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.51499495 |
| 41 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.48621550 |
| 42 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.45521640 |
| 43 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.45229528 |
| 44 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.45019402 |
| 45 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.44644186 |
| 46 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.42720259 |
| 47 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.42632538 |
| 48 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.41795919 |
| 49 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.41519270 |
| 50 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.39068360 |
| 51 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.38047537 |
| 52 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.37879275 |
| 53 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.37738413 |
| 54 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.37630992 |
| 55 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.33546364 |
| 56 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.31488815 |
| 57 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.29038668 |
| 58 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.27992783 |
| 59 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.27511399 |
| 60 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25534246 |
| 61 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.25477835 |
| 62 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.24322657 |
| 63 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.22738150 |
| 64 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.22731204 |
| 65 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.21943432 |
| 66 | P300_19829295_ChIP-Seq_ESCs_Human | 1.21359561 |
| 67 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.20070615 |
| 68 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.18805538 |
| 69 | FUS_26573619_Chip-Seq_HEK293_Human | 1.18277031 |
| 70 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.17408879 |
| 71 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.17164902 |
| 72 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.15320125 |
| 73 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.12971287 |
| 74 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.12905481 |
| 75 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.12141664 |
| 76 | KDM2B_26808549_Chip-Seq_K562_Human | 1.11180481 |
| 77 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.08042777 |
| 78 | TP53_16413492_ChIP-PET_HCT116_Human | 1.07398474 |
| 79 | STAT3_23295773_ChIP-Seq_U87_Human | 1.06517853 |
| 80 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.06493520 |
| 81 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.06009754 |
| 82 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.05582533 |
| 83 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.05430195 |
| 84 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04537620 |
| 85 | AR_19668381_ChIP-Seq_PC3_Human | 1.04220613 |
| 86 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.03484528 |
| 87 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.02868235 |
| 88 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.02621478 |
| 89 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.02053001 |
| 90 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.02053001 |
| 91 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.01721591 |
| 92 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 1.01255243 |
| 93 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.01056897 |
| 94 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00632170 |
| 95 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.99906908 |
| 96 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.99521922 |
| 97 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.99111798 |
| 98 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.98816807 |
| 99 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.98724035 |
| 100 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98104191 |
| 101 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.97913181 |
| 102 | TCF4_23295773_ChIP-Seq_U87_Human | 0.97612551 |
| 103 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.97020170 |
| 104 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.96804917 |
| 105 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.96634542 |
| 106 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.95691989 |
| 107 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.95314134 |
| 108 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94932398 |
| 109 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.94834983 |
| 110 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.94730059 |
| 111 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.93875734 |
| 112 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93749032 |
| 113 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.93749032 |
| 114 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.93670191 |
| 115 | AR_25329375_ChIP-Seq_VCAP_Human | 0.93496404 |
| 116 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.93452233 |
| 117 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.92810460 |
| 118 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.91660503 |
| 119 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.91230447 |
| 120 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.90843622 |
| 121 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.90710315 |
| 122 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.86353811 |
| 123 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.83459873 |
| 124 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.83383992 |
| 125 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82568734 |
| 126 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.81359026 |
| 127 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.79314375 |
| 128 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.78232492 |
| 129 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.77367278 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.62888110 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.19456187 |
| 3 | * MP0000920_abnormal_myelination | 3.33314888 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.08930520 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 3.06948626 |
| 6 | MP0004270_analgesia | 3.02553945 |
| 7 | MP0000778_abnormal_nervous_system | 2.92797427 |
| 8 | MP0004782_abnormal_surfactant_physiolog | 2.84101806 |
| 9 | MP0002064_seizures | 2.78632744 |
| 10 | MP0003690_abnormal_glial_cell | 2.75323959 |
| 11 | MP0005171_absent_coat_pigmentation | 2.74943536 |
| 12 | MP0001486_abnormal_startle_reflex | 2.60889420 |
| 13 | MP0009745_abnormal_behavioral_response | 2.56351599 |
| 14 | MP0004742_abnormal_vestibular_system | 2.51822677 |
| 15 | MP0004885_abnormal_endolymph | 2.43596983 |
| 16 | MP0003172_abnormal_lysosome_physiology | 2.43379710 |
| 17 | MP0002063_abnormal_learning/memory/cond | 2.33537153 |
| 18 | MP0002272_abnormal_nervous_system | 2.27854493 |
| 19 | * MP0003634_abnormal_glial_cell | 2.16413997 |
| 20 | MP0000751_myopathy | 2.15819181 |
| 21 | MP0004142_abnormal_muscle_tone | 2.13377093 |
| 22 | MP0002572_abnormal_emotion/affect_behav | 2.09569286 |
| 23 | MP0003136_yellow_coat_color | 2.08311467 |
| 24 | MP0009046_muscle_twitch | 2.06273346 |
| 25 | MP0000955_abnormal_spinal_cord | 1.97728329 |
| 26 | MP0004858_abnormal_nervous_system | 1.96846905 |
| 27 | MP0001968_abnormal_touch/_nociception | 1.89230855 |
| 28 | MP0002734_abnormal_mechanical_nocicepti | 1.89136171 |
| 29 | MP0004134_abnormal_chest_morphology | 1.78327155 |
| 30 | MP0003329_amyloid_beta_deposits | 1.75884028 |
| 31 | MP0005670_abnormal_white_adipose | 1.73947245 |
| 32 | MP0003632_abnormal_nervous_system | 1.73642228 |
| 33 | MP0002067_abnormal_sensory_capabilities | 1.70570416 |
| 34 | MP0002736_abnormal_nociception_after | 1.69517089 |
| 35 | MP0004145_abnormal_muscle_electrophysio | 1.67817631 |
| 36 | MP0005623_abnormal_meninges_morphology | 1.66881852 |
| 37 | MP0001986_abnormal_taste_sensitivity | 1.62788093 |
| 38 | MP0001529_abnormal_vocalization | 1.61188442 |
| 39 | MP0004215_abnormal_myocardial_fiber | 1.58961818 |
| 40 | MP0002882_abnormal_neuron_morphology | 1.56409767 |
| 41 | MP0009780_abnormal_chondrocyte_physiolo | 1.56321965 |
| 42 | MP0001905_abnormal_dopamine_level | 1.55480228 |
| 43 | MP0001440_abnormal_grooming_behavior | 1.55286335 |
| 44 | MP0001299_abnormal_eye_distance/ | 1.52883956 |
| 45 | MP0000462_abnormal_digestive_system | 1.50353079 |
| 46 | MP0008569_lethality_at_weaning | 1.47709359 |
| 47 | MP0002184_abnormal_innervation | 1.47133631 |
| 48 | MP0005409_darkened_coat_color | 1.46271417 |
| 49 | MP0009384_cardiac_valve_regurgitation | 1.44020443 |
| 50 | MP0002557_abnormal_social/conspecific_i | 1.40270743 |
| 51 | MP0002066_abnormal_motor_capabilities/c | 1.34474673 |
| 52 | MP0002733_abnormal_thermal_nociception | 1.33765266 |
| 53 | MP0002152_abnormal_brain_morphology | 1.28180511 |
| 54 | MP0001970_abnormal_pain_threshold | 1.27404024 |
| 55 | MP0005646_abnormal_pituitary_gland | 1.27364184 |
| 56 | MP0000749_muscle_degeneration | 1.26448686 |
| 57 | MP0001958_emphysema | 1.23871977 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 1.23477108 |
| 59 | MP0001485_abnormal_pinna_reflex | 1.23030630 |
| 60 | MP0003075_altered_response_to | 1.22868946 |
| 61 | MP0002822_catalepsy | 1.22510444 |
| 62 | MP0004811_abnormal_neuron_physiology | 1.20777411 |
| 63 | MP0001984_abnormal_olfaction | 1.20182018 |
| 64 | MP0003631_nervous_system_phenotype | 1.18505500 |
| 65 | MP0003879_abnormal_hair_cell | 1.14985270 |
| 66 | MP0005645_abnormal_hypothalamus_physiol | 1.13767596 |
| 67 | MP0001177_atelectasis | 1.10534754 |
| 68 | MP0004924_abnormal_behavior | 1.10110856 |
| 69 | MP0005386_behavior/neurological_phenoty | 1.10110856 |
| 70 | MP0005167_abnormal_blood-brain_barrier | 1.09802166 |
| 71 | MP0002229_neurodegeneration | 1.05291817 |
| 72 | MP0000467_abnormal_esophagus_morphology | 1.04018880 |
| 73 | MP0005257_abnormal_intraocular_pressure | 1.03079140 |
| 74 | MP0003633_abnormal_nervous_system | 1.01887617 |
| 75 | MP0002972_abnormal_cardiac_muscle | 1.01155902 |
| 76 | MP0002752_abnormal_somatic_nervous | 1.01050412 |
| 77 | MP0003385_abnormal_body_wall | 0.98890692 |
| 78 | MP0001963_abnormal_hearing_physiology | 0.98213424 |
| 79 | MP0000534_abnormal_ureter_morphology | 0.97640522 |
| 80 | MP0002282_abnormal_trachea_morphology | 0.94974671 |
| 81 | MP0000343_altered_response_to | 0.92470060 |
| 82 | MP0010678_abnormal_skin_adnexa | 0.91820831 |
| 83 | MP0005620_abnormal_muscle_contractility | 0.90359993 |
| 84 | MP0005551_abnormal_eye_electrophysiolog | 0.90195270 |
| 85 | MP0004185_abnormal_adipocyte_glucose | 0.90132546 |
| 86 | MP0004130_abnormal_muscle_cell | 0.89603552 |
| 87 | MP0002653_abnormal_ependyma_morphology | 0.88656517 |
| 88 | MP0003861_abnormal_nervous_system | 0.88141664 |
| 89 | MP0001943_abnormal_respiration | 0.84844590 |
| 90 | MP0002735_abnormal_chemical_nociception | 0.83917832 |
| 91 | MP0000026_abnormal_inner_ear | 0.83266508 |
| 92 | MP0004084_abnormal_cardiac_muscle | 0.82510575 |
| 93 | MP0002090_abnormal_vision | 0.82332313 |
| 94 | MP0003938_abnormal_ear_development | 0.82279628 |
| 95 | MP0009379_abnormal_foot_pigmentation | 0.82161381 |
| 96 | MP0003137_abnormal_impulse_conducting | 0.80986247 |
| 97 | MP0003115_abnormal_respiratory_system | 0.80710716 |
| 98 | MP0002332_abnormal_exercise_endurance | 0.80066181 |
| 99 | MP0001661_extended_life_span | 0.79397641 |
| 100 | MP0002909_abnormal_adrenal_gland | 0.79277314 |
| 101 | MP0001501_abnormal_sleep_pattern | 0.79080774 |
| 102 | MP0002751_abnormal_autonomic_nervous | 0.79013920 |
| 103 | MP0000604_amyloidosis | 0.78029707 |
| 104 | MP0005410_abnormal_fertilization | 0.77802657 |
| 105 | MP0006276_abnormal_autonomic_nervous | 0.76388221 |
| 106 | MP0003091_abnormal_cell_migration | 0.76370318 |
| 107 | MP0009250_abnormal_appendicular_skeleto | 0.75570545 |
| 108 | MP0005595_abnormal_vascular_smooth | 0.74543174 |
| 109 | MP0004484_altered_response_of | 0.74124114 |
| 110 | MP0004036_abnormal_muscle_relaxation | 0.73797391 |
| 111 | MP0002089_abnormal_postnatal_growth/wei | 0.72743720 |
| 112 | MP0000733_abnormal_muscle_development | 0.72316497 |
| 113 | MP0000579_abnormal_nail_morphology | 0.72219574 |
| 114 | MP0001502_abnormal_circadian_rhythm | 0.71024493 |
| 115 | MP0005535_abnormal_body_temperature | 0.70496637 |
| 116 | MP0002069_abnormal_eating/drinking_beha | 0.69038605 |
| 117 | MP0005166_decreased_susceptibility_to | 0.68851595 |
| 118 | MP0002638_abnormal_pupillary_reflex | 0.68799081 |
| 119 | MP0005195_abnormal_posterior_eye | 0.68618274 |
| 120 | MP0000647_abnormal_sebaceous_gland | 0.68500798 |
| 121 | MP0000747_muscle_weakness | 0.67900595 |
| 122 | MP0004381_abnormal_hair_follicle | 0.67192154 |
| 123 | MP0000762_abnormal_tongue_morphology | 0.66167358 |
| 124 | MP0002133_abnormal_respiratory_system | 0.64457166 |
| 125 | MP0005388_respiratory_system_phenotype | 0.64457166 |
| 126 | MP0006138_congestive_heart_failure | 0.63188334 |
| 127 | MP0004085_abnormal_heartbeat | 0.62995279 |
| 128 | MP0005165_increased_susceptibility_to | 0.61484124 |
| 129 | MP0003183_abnormal_peptide_metabolism | 0.61213214 |
| 130 | MP0010770_preweaning_lethality | 0.60602737 |
| 131 | MP0005666_abnormal_adipose_tissue | 0.59275699 |
| 132 | MP0004087_abnormal_muscle_fiber | 0.56044262 |
| 133 | MP0005253_abnormal_eye_physiology | 0.55530872 |
| 134 | MP0002249_abnormal_larynx_morphology | 0.55473348 |
| 135 | MP0002876_abnormal_thyroid_physiology | 0.54833402 |
| 136 | MP0003279_aneurysm | 0.54453390 |
| 137 | MP0010769_abnormal_survival | 0.54181561 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Peripheral hypomyelination (HP:0007182) | 4.74965258 |
| 2 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 4.49993935 |
| 3 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 4.49993935 |
| 4 | Myokymia (HP:0002411) | 4.29833253 |
| 5 | Neurofibrillary tangles (HP:0002185) | 4.04906410 |
| 6 | Abnormality of the corticospinal tract (HP:0002492) | 4.04572080 |
| 7 | Alacrima (HP:0000522) | 3.98844191 |
| 8 | Abnormality of the sella turcica (HP:0002679) | 3.59089101 |
| 9 | Action tremor (HP:0002345) | 3.58588858 |
| 10 | Sensory axonal neuropathy (HP:0003390) | 3.58227081 |
| 11 | Akinesia (HP:0002304) | 3.53320284 |
| 12 | Absent speech (HP:0001344) | 3.47245749 |
| 13 | Bundle branch block (HP:0011710) | 3.46305142 |
| 14 | Intention tremor (HP:0002080) | 3.36721885 |
| 15 | Obstructive sleep apnea (HP:0002870) | 3.33607956 |
| 16 | Decreased lacrimation (HP:0000633) | 3.31860953 |
| 17 | Spastic gait (HP:0002064) | 3.24232860 |
| 18 | Supranuclear gaze palsy (HP:0000605) | 3.22517440 |
| 19 | Abnormal auditory evoked potentials (HP:0006958) | 3.13137247 |
| 20 | Muscle fiber splitting (HP:0003555) | 3.12796561 |
| 21 | Ankle clonus (HP:0011448) | 3.09758657 |
| 22 | Cerebral inclusion bodies (HP:0100314) | 3.09065744 |
| 23 | Epiphyseal dysplasia (HP:0002656) | 3.05363722 |
| 24 | Atonic seizures (HP:0010819) | 3.04507363 |
| 25 | Focal motor seizures (HP:0011153) | 3.02369063 |
| 26 | Abnormality of the septum pellucidum (HP:0007375) | 3.01836435 |
| 27 | Diplopia (HP:0000651) | 3.01137470 |
| 28 | Abnormality of binocular vision (HP:0011514) | 3.01137470 |
| 29 | Oligodactyly (hands) (HP:0001180) | 2.97691786 |
| 30 | Vitreoretinal degeneration (HP:0000655) | 2.95308027 |
| 31 | Dysmetria (HP:0001310) | 2.92288811 |
| 32 | Blue irides (HP:0000635) | 2.88897374 |
| 33 | Premature skin wrinkling (HP:0100678) | 2.87608417 |
| 34 | Optic nerve hypoplasia (HP:0000609) | 2.86678922 |
| 35 | Hemiplegia (HP:0002301) | 2.84333506 |
| 36 | Anophthalmia (HP:0000528) | 2.77501430 |
| 37 | Hyperventilation (HP:0002883) | 2.76058589 |
| 38 | Hypoplasia of the iris (HP:0007676) | 2.71754795 |
| 39 | Hyporeflexia of lower limbs (HP:0002600) | 2.71252387 |
| 40 | Postural instability (HP:0002172) | 2.69280726 |
| 41 | Morphological abnormality of the inner ear (HP:0011390) | 2.68820516 |
| 42 | Focal seizures (HP:0007359) | 2.68080776 |
| 43 | Septo-optic dysplasia (HP:0100842) | 2.63673969 |
| 44 | Overgrowth (HP:0001548) | 2.62689665 |
| 45 | Subaortic stenosis (HP:0001682) | 2.62237335 |
| 46 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.62237335 |
| 47 | Cerebral hypomyelination (HP:0006808) | 2.60587563 |
| 48 | Progressive cerebellar ataxia (HP:0002073) | 2.59648577 |
| 49 | Dysdiadochokinesis (HP:0002075) | 2.59159610 |
| 50 | Generalized tonic-clonic seizures (HP:0002069) | 2.56860209 |
| 51 | Bell-shaped thorax (HP:0001591) | 2.56049615 |
| 52 | Abnormality of the ischium (HP:0003174) | 2.54682710 |
| 53 | Scanning speech (HP:0002168) | 2.49090727 |
| 54 | Spastic paraparesis (HP:0002313) | 2.48738145 |
| 55 | Excessive salivation (HP:0003781) | 2.48153344 |
| 56 | Drooling (HP:0002307) | 2.48153344 |
| 57 | Bowel incontinence (HP:0002607) | 2.47199178 |
| 58 | Megalencephaly (HP:0001355) | 2.45342263 |
| 59 | Abnormal eating behavior (HP:0100738) | 2.42315899 |
| 60 | Abnormality of the 4th metacarpal (HP:0010012) | 2.42119052 |
| 61 | Epileptic encephalopathy (HP:0200134) | 2.41647239 |
| 62 | Relative macrocephaly (HP:0004482) | 2.41599521 |
| 63 | Insidious onset (HP:0003587) | 2.40797507 |
| 64 | Termporal pattern (HP:0011008) | 2.40797507 |
| 65 | Fetal akinesia sequence (HP:0001989) | 2.39310548 |
| 66 | Split foot (HP:0001839) | 2.36461992 |
| 67 | Anomalous pulmonary venous return (HP:0010772) | 2.36072498 |
| 68 | Broad-based gait (HP:0002136) | 2.34796498 |
| 69 | Atrioventricular block (HP:0001678) | 2.33839438 |
| 70 | Visual hallucinations (HP:0002367) | 2.33394315 |
| 71 | White forelock (HP:0002211) | 2.30136060 |
| 72 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.27354377 |
| 73 | Pheochromocytoma (HP:0002666) | 2.25652348 |
| 74 | Lower limb muscle weakness (HP:0007340) | 2.23870605 |
| 75 | Abnormal large intestine physiology (HP:0012700) | 2.23686925 |
| 76 | Abnormality of cochlea (HP:0000375) | 2.23432442 |
| 77 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.22753427 |
| 78 | Retinal dysplasia (HP:0007973) | 2.22687034 |
| 79 | Urinary urgency (HP:0000012) | 2.22527927 |
| 80 | Heart block (HP:0012722) | 2.22143366 |
| 81 | Metabolic alkalosis (HP:0200114) | 2.21990194 |
| 82 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.21453476 |
| 83 | Ventricular fibrillation (HP:0001663) | 2.18726762 |
| 84 | Microglossia (HP:0000171) | 2.18000818 |
| 85 | Delayed CNS myelination (HP:0002188) | 2.17877002 |
| 86 | Abnormal atrioventricular conduction (HP:0005150) | 2.14535332 |
| 87 | Limb dystonia (HP:0002451) | 2.13614659 |
| 88 | Synostosis of carpal bones (HP:0005048) | 2.13586021 |
| 89 | Small epiphyses (HP:0010585) | 2.13560686 |
| 90 | Abnormality of the pulmonary veins (HP:0011718) | 2.13096041 |
| 91 | Hypoplastic pelvis (HP:0008839) | 2.12860005 |
| 92 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.12511826 |
| 93 | Generalized myoclonic seizures (HP:0002123) | 2.12304916 |
| 94 | Hypoplastic ischia (HP:0003175) | 2.11693986 |
| 95 | Onion bulb formation (HP:0003383) | 2.10375592 |
| 96 | Chin dimple (HP:0010751) | 2.09027519 |
| 97 | Patchy hypopigmentation of hair (HP:0011365) | 2.07534584 |
| 98 | Abnormality of the parathyroid morphology (HP:0011766) | 2.05889688 |
| 99 | Hypokalemic alkalosis (HP:0001949) | 2.05097868 |
| 100 | Abnormality of oral frenula (HP:0000190) | 2.04461495 |
| 101 | Sudden death (HP:0001699) | 2.02646859 |
| 102 | Adrenal hypoplasia (HP:0000835) | 2.02574779 |
| 103 | Oligodactyly (HP:0012165) | 2.01286633 |
| 104 | Vertebral clefting (HP:0008428) | 2.01213089 |
| 105 | Broad ribs (HP:0000885) | 1.99653060 |
| 106 | Pachygyria (HP:0001302) | 1.99266781 |
| 107 | Aplasia involving bones of the extremities (HP:0009825) | 1.98130334 |
| 108 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.98130334 |
| 109 | Aplasia of the phalanges of the hand (HP:0009802) | 1.98130334 |
| 110 | Enlarged epiphyses (HP:0010580) | 1.97924695 |
| 111 | Atrial fibrillation (HP:0005110) | 1.96703395 |
| 112 | Fibular hypoplasia (HP:0003038) | 1.96645640 |
| 113 | Gaze-evoked nystagmus (HP:0000640) | 1.95897941 |
| 114 | Heterochromia iridis (HP:0001100) | 1.95634097 |
| 115 | Insomnia (HP:0100785) | 1.94464035 |
| 116 | Hyperthyroidism (HP:0000836) | 1.94165737 |
| 117 | Large earlobe (HP:0009748) | 1.93088075 |
| 118 | Postural tremor (HP:0002174) | 1.92798928 |
| 119 | Pulmonic stenosis (HP:0001642) | 1.91461649 |
| 120 | Depression (HP:0000716) | 1.91018541 |
| 121 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.90915594 |
| 122 | Prolonged QT interval (HP:0001657) | 1.89986820 |
| 123 | Primary atrial arrhythmia (HP:0001692) | 1.89449338 |
| 124 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.88569644 |
| 125 | Congenital sensorineural hearing impairment (HP:0008527) | 1.88481064 |
| 126 | Slow saccadic eye movements (HP:0000514) | 1.86813975 |
| 127 | Mutism (HP:0002300) | 1.86250800 |
| 128 | Ankyloglossia (HP:0010296) | 1.86239433 |
| 129 | Bifid scrotum (HP:0000048) | 1.86100287 |
| 130 | Papilledema (HP:0001085) | 1.86097608 |
| 131 | Thickened helices (HP:0000391) | 1.86015078 |
| 132 | Absent septum pellucidum (HP:0001331) | 1.85981095 |
| 133 | Cortical dysplasia (HP:0002539) | 1.85509901 |
| 134 | Macroorchidism (HP:0000053) | 1.85061425 |
| 135 | Anxiety (HP:0000739) | 1.82889154 |
| 136 | Neuroendocrine neoplasm (HP:0100634) | 1.82878834 |
| 137 | Truncal ataxia (HP:0002078) | 1.82449837 |
| 138 | Absent epiphyses (HP:0010577) | 1.82028160 |
| 139 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.82028160 |
| 140 | Coronal craniosynostosis (HP:0004440) | 1.81734024 |
| 141 | Clumsiness (HP:0002312) | 1.79379237 |
| 142 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.77861727 |
| 143 | Increased circulating renin level (HP:0000848) | 1.77387177 |
| 144 | Supraventricular tachycardia (HP:0004755) | 1.77131191 |
| 145 | Supraventricular arrhythmia (HP:0005115) | 1.76180235 |
| 146 | Type II lissencephaly (HP:0007260) | 1.76127997 |
| 147 | Myotonia (HP:0002486) | 1.75963142 |
| 148 | Clonus (HP:0002169) | 1.75767394 |
| 149 | Anosmia (HP:0000458) | 1.75697856 |
| 150 | Supernumerary ribs (HP:0005815) | 1.75228061 |
| 151 | Hemiparesis (HP:0001269) | 1.75063545 |
| 152 | Absence seizures (HP:0002121) | 1.74526369 |
| 153 | Truncus arteriosus (HP:0001660) | 1.73612543 |
| 154 | Laryngomalacia (HP:0001601) | 1.73435999 |
| 155 | Intellectual disability, moderate (HP:0002342) | 1.73307306 |
| 156 | Mitral stenosis (HP:0001718) | 1.72927689 |
| 157 | Sleep apnea (HP:0010535) | 1.72512203 |
| 158 | Torticollis (HP:0000473) | 1.72331660 |
| 159 | Ventricular arrhythmia (HP:0004308) | 1.72284055 |
| 160 | Esophageal atresia (HP:0002032) | 1.72010911 |
| 161 | Abnormality of the foot musculature (HP:0001436) | 1.71802166 |
| 162 | Pulmonary artery stenosis (HP:0004415) | 1.70402211 |
| 163 | Abnormal EKG (HP:0003115) | 1.70136950 |
| 164 | Paraparesis (HP:0002385) | 1.69611929 |
| 165 | Germ cell neoplasia (HP:0100728) | 1.68831060 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TYRO3 | 6.21362317 |
| 2 | TNIK | 4.36036210 |
| 3 | FES | 4.22195743 |
| 4 | CASK | 3.61014640 |
| 5 | ICK | 2.58282385 |
| 6 | MARK1 | 2.44488481 |
| 7 | STK39 | 2.33324123 |
| 8 | EPHA4 | 2.26710885 |
| 9 | PDGFRB | 2.08825631 |
| 10 | TNK2 | 2.08180601 |
| 11 | EPHB1 | 1.95894178 |
| 12 | NTRK2 | 1.87007959 |
| 13 | NEK6 | 1.81043975 |
| 14 | IRAK2 | 1.79110807 |
| 15 | NTRK3 | 1.77058487 |
| 16 | OXSR1 | 1.72496902 |
| 17 | PAK6 | 1.62622650 |
| 18 | PRPF4B | 1.57792192 |
| 19 | NTRK1 | 1.52276474 |
| 20 | LIMK1 | 1.52181584 |
| 21 | PIK3CA | 1.49406844 |
| 22 | PKN1 | 1.44297000 |
| 23 | SGK2 | 1.33668279 |
| 24 | MAPK13 | 1.32945293 |
| 25 | MAP3K4 | 1.32931743 |
| 26 | PHKG2 | 1.32336708 |
| 27 | PHKG1 | 1.32336708 |
| 28 | AKT3 | 1.27011937 |
| 29 | UHMK1 | 1.22869789 |
| 30 | CSK | 1.19842543 |
| 31 | RIPK1 | 1.14467217 |
| 32 | IRAK1 | 1.11733940 |
| 33 | TESK2 | 1.11601175 |
| 34 | MINK1 | 1.08498299 |
| 35 | MAP3K2 | 1.07613842 |
| 36 | CDK19 | 1.06879935 |
| 37 | PDGFRA | 1.05731548 |
| 38 | ROCK2 | 1.03529139 |
| 39 | KSR1 | 1.01476349 |
| 40 | RET | 1.01030897 |
| 41 | CDK5 | 1.00135070 |
| 42 | CSNK1G3 | 0.99026286 |
| 43 | CAMK1G | 0.97581123 |
| 44 | PBK | 0.97429851 |
| 45 | ERBB4 | 0.97180909 |
| 46 | PAK3 | 0.96961055 |
| 47 | ERBB2 | 0.96462805 |
| 48 | MAPK12 | 0.94744504 |
| 49 | FGR | 0.94501866 |
| 50 | SGK3 | 0.93696231 |
| 51 | CSNK1G2 | 0.93252255 |
| 52 | PINK1 | 0.93234873 |
| 53 | TAOK1 | 0.93158135 |
| 54 | KSR2 | 0.91541582 |
| 55 | CSNK1A1L | 0.91040951 |
| 56 | FGFR2 | 0.89929099 |
| 57 | DMPK | 0.86605364 |
| 58 | ROCK1 | 0.83379738 |
| 59 | FYN | 0.79890643 |
| 60 | PNCK | 0.79844887 |
| 61 | CAMK1 | 0.78778410 |
| 62 | MET | 0.76328790 |
| 63 | CSNK1G1 | 0.74714752 |
| 64 | MYLK | 0.74703027 |
| 65 | LMTK2 | 0.74330128 |
| 66 | MAPKAPK5 | 0.72495240 |
| 67 | TTN | 0.71080857 |
| 68 | WNK4 | 0.70204671 |
| 69 | SGK223 | 0.69389133 |
| 70 | SGK494 | 0.69389133 |
| 71 | MAP3K7 | 0.68519572 |
| 72 | MAP3K9 | 0.68185640 |
| 73 | BCR | 0.67762871 |
| 74 | MAPK10 | 0.67203953 |
| 75 | DAPK2 | 0.67192007 |
| 76 | CDK14 | 0.65514002 |
| 77 | CAMK2A | 0.63131388 |
| 78 | PLK2 | 0.62738035 |
| 79 | CAMK2B | 0.62253053 |
| 80 | CAMK2D | 0.61109379 |
| 81 | DYRK2 | 0.60167055 |
| 82 | WNK1 | 0.58706729 |
| 83 | PRKCH | 0.58408384 |
| 84 | CAMK4 | 0.57291557 |
| 85 | MAP3K6 | 0.56005449 |
| 86 | MARK2 | 0.54757933 |
| 87 | INSR | 0.52813687 |
| 88 | DDR2 | 0.52687872 |
| 89 | CDK15 | 0.52205784 |
| 90 | PRKCQ | 0.51824757 |
| 91 | AKT2 | 0.51150496 |
| 92 | ILK | 0.50471733 |
| 93 | CAMKK1 | 0.49899039 |
| 94 | RAF1 | 0.49777443 |
| 95 | ALK | 0.49750594 |
| 96 | MAPK7 | 0.49705354 |
| 97 | CDK18 | 0.48701721 |
| 98 | STK11 | 0.48664478 |
| 99 | PRKG1 | 0.48025710 |
| 100 | PTK2 | 0.47701709 |
| 101 | TESK1 | 0.46339057 |
| 102 | PDPK1 | 0.46106679 |
| 103 | CDK11A | 0.46022356 |
| 104 | BMX | 0.45930108 |
| 105 | CAMK1D | 0.45922701 |
| 106 | MAPK4 | 0.45239095 |
| 107 | PDK2 | 0.45229268 |
| 108 | CDK8 | 0.44891313 |
| 109 | TIE1 | 0.44801676 |
| 110 | MAP2K7 | 0.44396107 |
| 111 | SIK2 | 0.44162722 |
| 112 | SRC | 0.41938802 |
| 113 | RPS6KA3 | 0.41853126 |
| 114 | PRKCG | 0.41588421 |
| 115 | CAMK2G | 0.40412519 |
| 116 | PRKCE | 0.39223399 |
| 117 | CSNK1D | 0.39080293 |
| 118 | MAP2K4 | 0.38468999 |
| 119 | OBSCN | 0.38406632 |
| 120 | STK38L | 0.37855972 |
| 121 | PRKD1 | 0.37017468 |
| 122 | PRKD3 | 0.36564021 |
| 123 | MAP2K1 | 0.36550197 |
| 124 | STK38 | 0.34027882 |
| 125 | GSK3A | 0.33709507 |
| 126 | DYRK1A | 0.33466473 |
| 127 | SGK1 | 0.32752461 |
| 128 | ABL2 | 0.31774395 |
| 129 | SIK1 | 0.30546094 |
| 130 | IGF1R | 0.28723198 |
| 131 | JAK1 | 0.26816467 |
| 132 | PRKACG | 0.26430567 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.72926119 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.64999439 |
| 3 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.38448774 |
| 4 | Axon guidance_Homo sapiens_hsa04360 | 2.33998647 |
| 5 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.23966147 |
| 6 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.11856044 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.00173741 |
| 8 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.93527282 |
| 9 | Nicotine addiction_Homo sapiens_hsa05033 | 1.92206097 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.82145258 |
| 11 | Circadian entrainment_Homo sapiens_hsa04713 | 1.81601925 |
| 12 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.81045774 |
| 13 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.72970853 |
| 14 | Prion diseases_Homo sapiens_hsa05020 | 1.69343417 |
| 15 | Morphine addiction_Homo sapiens_hsa05032 | 1.63937611 |
| 16 | Long-term depression_Homo sapiens_hsa04730 | 1.61372605 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.59521093 |
| 18 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.53751013 |
| 19 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.50572342 |
| 20 | Olfactory transduction_Homo sapiens_hsa04740 | 1.47095129 |
| 21 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.45710425 |
| 22 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.44348082 |
| 23 | Long-term potentiation_Homo sapiens_hsa04720 | 1.42317472 |
| 24 | Salivary secretion_Homo sapiens_hsa04970 | 1.40193308 |
| 25 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.37245244 |
| 26 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.37186833 |
| 27 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.34566592 |
| 28 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.32588220 |
| 29 | Bile secretion_Homo sapiens_hsa04976 | 1.30259852 |
| 30 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.29822624 |
| 31 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.28762075 |
| 32 | Gap junction_Homo sapiens_hsa04540 | 1.28334114 |
| 33 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.27261711 |
| 34 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.26623994 |
| 35 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.24193034 |
| 36 | Renin secretion_Homo sapiens_hsa04924 | 1.23274245 |
| 37 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.22604179 |
| 38 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.16797825 |
| 39 | Cocaine addiction_Homo sapiens_hsa05030 | 1.13921990 |
| 40 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.13844266 |
| 41 | Glioma_Homo sapiens_hsa05214 | 1.13020036 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.10108089 |
| 43 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.08817860 |
| 44 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.08806945 |
| 45 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.08621751 |
| 46 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.07278792 |
| 47 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.05785207 |
| 48 | Insulin secretion_Homo sapiens_hsa04911 | 1.05488594 |
| 49 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.04415671 |
| 50 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.02227465 |
| 51 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.01223213 |
| 52 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.99550123 |
| 53 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.98281988 |
| 54 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.95894075 |
| 55 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.95377548 |
| 56 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.94338709 |
| 57 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.93749626 |
| 58 | Tight junction_Homo sapiens_hsa04530 | 0.93039216 |
| 59 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.91328664 |
| 60 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.90821920 |
| 61 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.87393942 |
| 62 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.86119715 |
| 63 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.85639248 |
| 64 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.83970872 |
| 65 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.83427336 |
| 66 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.81925254 |
| 67 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.81331502 |
| 68 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.81248136 |
| 69 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.80812561 |
| 70 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.79719641 |
| 71 | Histidine metabolism_Homo sapiens_hsa00340 | 0.79462779 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.79036911 |
| 73 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.78046766 |
| 74 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.77929317 |
| 75 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.75875100 |
| 76 | Focal adhesion_Homo sapiens_hsa04510 | 0.75644828 |
| 77 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.70901880 |
| 78 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.70697356 |
| 79 | Melanogenesis_Homo sapiens_hsa04916 | 0.70692770 |
| 80 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.70535825 |
| 81 | Circadian rhythm_Homo sapiens_hsa04710 | 0.69505429 |
| 82 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.67875159 |
| 83 | Platelet activation_Homo sapiens_hsa04611 | 0.67730407 |
| 84 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.67570569 |
| 85 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.67328688 |
| 86 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.64618602 |
| 87 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.62886214 |
| 88 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.62381297 |
| 89 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.61394235 |
| 90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.61392125 |
| 91 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.60632322 |
| 92 | Endocytosis_Homo sapiens_hsa04144 | 0.60169896 |
| 93 | Viral myocarditis_Homo sapiens_hsa05416 | 0.59839170 |
| 94 | Other glycan degradation_Homo sapiens_hsa00511 | 0.59245983 |
| 95 | Taste transduction_Homo sapiens_hsa04742 | 0.58185895 |
| 96 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.57577753 |
| 97 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.56459052 |
| 98 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.55995862 |
| 99 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.55161036 |
| 100 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.54930535 |
| 101 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.54618288 |
| 102 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.54448816 |
| 103 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.53038699 |
| 104 | Colorectal cancer_Homo sapiens_hsa05210 | 0.52080569 |
| 105 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.51921324 |
| 106 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.50930194 |
| 107 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.49808694 |
| 108 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.48441151 |
| 109 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.48337091 |
| 110 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.48039019 |
| 111 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.46774834 |
| 112 | Endometrial cancer_Homo sapiens_hsa05213 | 0.46366417 |
| 113 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.46204189 |
| 114 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.43992320 |
| 115 | Melanoma_Homo sapiens_hsa05218 | 0.43850326 |
| 116 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.43692877 |
| 117 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.43390524 |
| 118 | Amoebiasis_Homo sapiens_hsa05146 | 0.42811685 |
| 119 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.41455065 |
| 120 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.41051256 |
| 121 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.40402216 |
| 122 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.40221412 |
| 123 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.39816544 |
| 124 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.39770044 |
| 125 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.38880842 |
| 126 | Lysine degradation_Homo sapiens_hsa00310 | 0.38557268 |
| 127 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.38136517 |
| 128 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37436501 |

