

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cytidine metabolic process (GO:0046087) | 7.80987649 |
| 2 | cytidine catabolic process (GO:0006216) | 7.80987649 |
| 3 | cytidine deamination (GO:0009972) | 7.80987649 |
| 4 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 7.03478379 |
| 5 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 6.38328073 |
| 6 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.61968579 |
| 7 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.23971535 |
| 8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.18490252 |
| 9 | activated T cell proliferation (GO:0050798) | 5.16563864 |
| 10 | regulation of lymphocyte chemotaxis (GO:1901623) | 5.12405014 |
| 11 | regulation of chronic inflammatory response (GO:0002676) | 5.10440627 |
| 12 | interferon-gamma production (GO:0032609) | 4.81405211 |
| 13 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.79658010 |
| 14 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.79658010 |
| 15 | mature B cell differentiation involved in immune response (GO:0002313) | 4.76317377 |
| 16 | positive T cell selection (GO:0043368) | 4.68490636 |
| 17 | regulation of T cell tolerance induction (GO:0002664) | 4.66785941 |
| 18 | negative regulation by host of viral transcription (GO:0043922) | 4.61783776 |
| 19 | regulation of T cell chemotaxis (GO:0010819) | 4.61774809 |
| 20 | positive regulation of T cell chemotaxis (GO:0010820) | 4.61774809 |
| 21 | ribosomal small subunit assembly (GO:0000028) | 4.59920564 |
| 22 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.59097972 |
| 23 | defense response to protozoan (GO:0042832) | 4.43058200 |
| 24 | regulation of cell killing (GO:0031341) | 4.43035731 |
| 25 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.42249728 |
| 26 | positive regulation of calcium-mediated signaling (GO:0050850) | 4.42037673 |
| 27 | positive regulation of tolerance induction (GO:0002645) | 4.33200649 |
| 28 | negative regulation of cell killing (GO:0031342) | 4.25215141 |
| 29 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.25215141 |
| 30 | mature B cell differentiation (GO:0002335) | 4.21510680 |
| 31 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 4.19551532 |
| 32 | response to protozoan (GO:0001562) | 4.19375877 |
| 33 | positive regulation of lymphocyte migration (GO:2000403) | 4.15432637 |
| 34 | lymph node development (GO:0048535) | 4.12466507 |
| 35 | positive regulation of B cell differentiation (GO:0045579) | 4.12401189 |
| 36 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.06568880 |
| 37 | mast cell activation (GO:0045576) | 4.03904070 |
| 38 | cellular response to interleukin-15 (GO:0071350) | 4.00881648 |
| 39 | thymic T cell selection (GO:0045061) | 4.00143956 |
| 40 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.93877946 |
| 41 | regulation of tolerance induction (GO:0002643) | 3.90843555 |
| 42 | regulation of B cell differentiation (GO:0045577) | 3.90602303 |
| 43 | lymphocyte chemotaxis (GO:0048247) | 3.90167626 |
| 44 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.86899074 |
| 45 | response to interleukin-15 (GO:0070672) | 3.81243377 |
| 46 | definitive hemopoiesis (GO:0060216) | 3.79578652 |
| 47 | regulation of gamma-delta T cell activation (GO:0046643) | 3.77632830 |
| 48 | T cell selection (GO:0045058) | 3.71453572 |
| 49 | negative regulation of T cell apoptotic process (GO:0070233) | 3.69598988 |
| 50 | negative regulation of viral genome replication (GO:0045071) | 3.67541705 |
| 51 | negative regulation of T cell mediated immunity (GO:0002710) | 3.67450210 |
| 52 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.64120619 |
| 53 | Peyers patch development (GO:0048541) | 3.62330274 |
| 54 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.62330274 |
| 55 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.57315099 |
| 56 | positive regulation of isotype switching (GO:0045830) | 3.49584459 |
| 57 | immunoglobulin mediated immune response (GO:0016064) | 3.47603524 |
| 58 | T cell receptor signaling pathway (GO:0050852) | 3.47046235 |
| 59 | B cell receptor signaling pathway (GO:0050853) | 3.46405550 |
| 60 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.46024121 |
| 61 | dosage compensation (GO:0007549) | 3.43495462 |
| 62 | cellular response to type I interferon (GO:0071357) | 3.42595187 |
| 63 | type I interferon signaling pathway (GO:0060337) | 3.42595187 |
| 64 | response to type I interferon (GO:0034340) | 3.42120693 |
| 65 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.39883656 |
| 66 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.39484214 |
| 67 | myeloid dendritic cell activation (GO:0001773) | 3.39412701 |
| 68 | regulation of activation of Janus kinase activity (GO:0010533) | 3.38964648 |
| 69 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.38946235 |
| 70 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.38271069 |
| 71 | T cell homeostasis (GO:0043029) | 3.36630244 |
| 72 | response to interferon-beta (GO:0035456) | 3.35794416 |
| 73 | regulation of lymphocyte migration (GO:2000401) | 3.34631394 |
| 74 | eosinophil chemotaxis (GO:0048245) | 3.34388635 |
| 75 | negative T cell selection (GO:0043383) | 3.33567609 |
| 76 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.32031214 |
| 77 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.32014205 |
| 78 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.31612252 |
| 79 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.28512984 |
| 80 | negative thymic T cell selection (GO:0045060) | 3.27916158 |
| 81 | cellular defense response (GO:0006968) | 3.26777710 |
| 82 | positive regulation of interleukin-17 production (GO:0032740) | 3.24133566 |
| 83 | lymphocyte costimulation (GO:0031294) | 3.23227302 |
| 84 | T cell migration (GO:0072678) | 3.23190703 |
| 85 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.22253285 |
| 86 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.22064409 |
| 87 | T cell costimulation (GO:0031295) | 3.20148084 |
| 88 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.19996463 |
| 89 | regulation of calcium-mediated signaling (GO:0050848) | 3.19987838 |
| 90 | lymphocyte migration (GO:0072676) | 3.18408016 |
| 91 | positive regulation of leukocyte mediated immunity (GO:0002705) | 3.17935270 |
| 92 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.17088364 |
| 93 | positive regulation of DNA recombination (GO:0045911) | 3.16086829 |
| 94 | positive regulation of T cell migration (GO:2000406) | 3.13221096 |
| 95 | regulation of lymphocyte mediated immunity (GO:0002706) | 3.11886459 |
| 96 | viral transcription (GO:0019083) | 3.10438001 |
| 97 | positive regulation of humoral immune response (GO:0002922) | 3.09590008 |
| 98 | positive regulation of defense response to virus by host (GO:0002230) | 3.08196246 |
| 99 | cellular response to interferon-beta (GO:0035458) | 3.08073563 |
| 100 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.07392016 |
| 101 | alpha-beta T cell activation (GO:0046631) | 3.06315213 |
| 102 | positive regulation of T cell mediated immunity (GO:0002711) | 3.05948256 |
| 103 | T cell mediated immunity (GO:0002456) | 3.05360637 |
| 104 | leukocyte aggregation (GO:0070486) | 3.04993504 |
| 105 | negative regulation of viral transcription (GO:0032897) | 3.04921693 |
| 106 | lymphoid progenitor cell differentiation (GO:0002320) | 3.04029140 |
| 107 | eosinophil migration (GO:0072677) | 3.00821831 |
| 108 | megakaryocyte development (GO:0035855) | 3.00357169 |
| 109 | mast cell activation involved in immune response (GO:0002279) | 2.98729885 |
| 110 | mast cell degranulation (GO:0043303) | 2.98729885 |
| 111 | positive regulation of interleukin-10 production (GO:0032733) | 2.97565360 |
| 112 | translational termination (GO:0006415) | 2.97410027 |
| 113 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.97185565 |
| 114 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.96257930 |
| 115 | positive regulation of B cell mediated immunity (GO:0002714) | 2.96257930 |
| 116 | regulation of T cell migration (GO:2000404) | 2.96147058 |
| 117 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.95077348 |
| 118 | leukocyte homeostasis (GO:0001776) | 2.93751848 |
| 119 | negative regulation of adaptive immune response (GO:0002820) | 2.92923778 |
| 120 | B cell mediated immunity (GO:0019724) | 2.87736299 |
| 121 | alpha-beta T cell differentiation (GO:0046632) | 2.85693794 |
| 122 | platelet dense granule organization (GO:0060155) | 2.84337230 |
| 123 | positive regulation of granulocyte differentiation (GO:0030854) | 2.83938057 |
| 124 | myeloid dendritic cell differentiation (GO:0043011) | 2.83499192 |
| 125 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.82400434 |
| 126 | regulation of response to interferon-gamma (GO:0060330) | 2.81642606 |
| 127 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.81614362 |
| 128 | natural killer cell activation (GO:0030101) | 2.81473247 |
| 129 | negative regulation of phagocytosis (GO:0050765) | 2.80691048 |
| 130 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.78726206 |
| 131 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.78726206 |
| 132 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.78260871 |
| 133 | positive regulation of macrophage differentiation (GO:0045651) | 2.77916582 |
| 134 | regulation of B cell mediated immunity (GO:0002712) | 2.76966474 |
| 135 | ribosomal small subunit biogenesis (GO:0042274) | 2.75370162 |
| 136 | cellular response to exogenous dsRNA (GO:0071360) | 2.75148146 |
| 137 | T cell differentiation (GO:0030217) | 2.75145524 |
| 138 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.75031476 |
| 139 | regulation of isotype switching (GO:0045191) | 2.74978204 |
| 140 | positive regulation of interferon-gamma production (GO:0032729) | 2.74702376 |
| 141 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.74621830 |
| 142 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.74600675 |
| 143 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.74600675 |
| 144 | positive regulation of B cell activation (GO:0050871) | 2.73133400 |
| 145 | germinal center formation (GO:0002467) | 2.72932296 |
| 146 | positive thymic T cell selection (GO:0045059) | 2.72584734 |
| 147 | lymphocyte homeostasis (GO:0002260) | 2.72073946 |
| 148 | positive regulation of cell killing (GO:0031343) | 2.70832674 |
| 149 | response to interferon-alpha (GO:0035455) | 2.69871799 |
| 150 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 2.69626574 |
| 151 | NIK/NF-kappaB signaling (GO:0038061) | 2.68344688 |
| 152 | DNA deamination (GO:0045006) | 2.67740154 |
| 153 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.67472817 |
| 154 | regulation of regulatory T cell differentiation (GO:0045589) | 2.66206899 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.12026857 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.85771682 |
| 3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.85671965 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.37332965 |
| 5 | * STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.14144189 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.02289001 |
| 7 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.73022897 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.69778934 |
| 9 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.64584259 |
| 10 | SCL_19346495_ChIP-Seq_HPC-7_Human | 3.29149548 |
| 11 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.15048159 |
| 12 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.14728583 |
| 13 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.97657575 |
| 14 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.94022494 |
| 15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.89376003 |
| 16 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.85893328 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.79131227 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.70153594 |
| 19 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.60889918 |
| 20 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.51343811 |
| 21 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.50932259 |
| 22 | * MYB_26560356_Chip-Seq_TH2_Human | 2.47809540 |
| 23 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.39951683 |
| 24 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.39007379 |
| 25 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.33103281 |
| 26 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.31140526 |
| 27 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.29453986 |
| 28 | MYC_22102868_ChIP-Seq_BL_Human | 2.26338558 |
| 29 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.26128405 |
| 30 | * MYB_26560356_Chip-Seq_TH1_Human | 2.13558780 |
| 31 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.12580791 |
| 32 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.07521583 |
| 33 | MAF_26560356_Chip-Seq_TH1_Human | 2.05548457 |
| 34 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.01463565 |
| 35 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.99534383 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.96344764 |
| 37 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.94469893 |
| 38 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90152312 |
| 39 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.89500371 |
| 40 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.87276457 |
| 41 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.82553323 |
| 42 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.81207034 |
| 43 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80987338 |
| 44 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.78814976 |
| 45 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.76306899 |
| 46 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.74384584 |
| 47 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.69010911 |
| 48 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.68572467 |
| 49 | UTX_26944678_Chip-Seq_JUKART_Human | 1.67521263 |
| 50 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.67054367 |
| 51 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.66948762 |
| 52 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.63470289 |
| 53 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.58247535 |
| 54 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.56909189 |
| 55 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.54576831 |
| 56 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.50101121 |
| 57 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.48096854 |
| 58 | VDR_22108803_ChIP-Seq_LS180_Human | 1.47308539 |
| 59 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.46957697 |
| 60 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.44861541 |
| 61 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.42279563 |
| 62 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.40727658 |
| 63 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.38721972 |
| 64 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.36570576 |
| 65 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.34594952 |
| 66 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.32274308 |
| 67 | GATA1_22025678_ChIP-Seq_K562_Human | 1.31401669 |
| 68 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.31388633 |
| 69 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.30539744 |
| 70 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.29816667 |
| 71 | * GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.29413868 |
| 72 | * MAF_26560356_Chip-Seq_TH2_Human | 1.27859970 |
| 73 | SPI1_23127762_ChIP-Seq_K562_Human | 1.26971446 |
| 74 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.26610245 |
| 75 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.25708940 |
| 76 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.19837578 |
| 77 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.18638323 |
| 78 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.18581802 |
| 79 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.18562412 |
| 80 | * GATA3_26560356_Chip-Seq_TH2_Human | 1.14369952 |
| 81 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.12374448 |
| 82 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.08206877 |
| 83 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.07352010 |
| 84 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.07319347 |
| 85 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.07051984 |
| 86 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.05760271 |
| 87 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 1.03925821 |
| 88 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.03189644 |
| 89 | GATA3_26560356_Chip-Seq_TH1_Human | 1.02444372 |
| 90 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01581237 |
| 91 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01299611 |
| 92 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.00966163 |
| 93 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.00237128 |
| 94 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.99229002 |
| 95 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.98818569 |
| 96 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.98304131 |
| 97 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.97936537 |
| 98 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.97202518 |
| 99 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.95012882 |
| 100 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.94664083 |
| 101 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92878836 |
| 102 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.92032414 |
| 103 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.91425162 |
| 104 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.90327223 |
| 105 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.88742233 |
| 106 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.88421573 |
| 107 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.87266462 |
| 108 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.84361022 |
| 109 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84047397 |
| 110 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.82251831 |
| 111 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.81653066 |
| 112 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.80870649 |
| 113 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.80324484 |
| 114 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.80225095 |
| 115 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.79999979 |
| 116 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.79903784 |
| 117 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.77783862 |
| 118 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.77421062 |
| 119 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.77340280 |
| 120 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.75273504 |
| 121 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.75265569 |
| 122 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.74951091 |
| 123 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.74721334 |
| 124 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.74721334 |
| 125 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.74416916 |
| 126 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.73229372 |
| 127 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.71683039 |
| 128 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.71451224 |
| 129 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.70936898 |
| 130 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.70924119 |
| 131 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.70719941 |
| 132 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.69020645 |
| 133 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.68530308 |
| 134 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.68437827 |
| 135 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.67455073 |
| 136 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.66272686 |
| 137 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.64605529 |
| 138 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.64550994 |
| 139 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.64539195 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.72922514 |
| 2 | MP0005671_abnormal_response_to | 4.38365804 |
| 3 | MP0009785_altered_susceptibility_to | 3.60475925 |
| 4 | MP0000685_abnormal_immune_system | 3.31614276 |
| 5 | MP0003763_abnormal_thymus_physiology | 3.30439272 |
| 6 | MP0002396_abnormal_hematopoietic_system | 3.29200543 |
| 7 | MP0001800_abnormal_humoral_immune | 3.05737006 |
| 8 | MP0002148_abnormal_hypersensitivity_rea | 2.92832275 |
| 9 | MP0005025_abnormal_response_to | 2.89255035 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.84068293 |
| 11 | MP0002723_abnormal_immune_serum | 2.74946644 |
| 12 | MP0002452_abnormal_antigen_presenting | 2.73513496 |
| 13 | MP0001790_abnormal_immune_system | 2.72588446 |
| 14 | MP0005387_immune_system_phenotype | 2.72588446 |
| 15 | MP0002420_abnormal_adaptive_immunity | 2.70816934 |
| 16 | MP0001819_abnormal_immune_cell | 2.69246005 |
| 17 | MP0003436_decreased_susceptibility_to | 2.66242285 |
| 18 | MP0002398_abnormal_bone_marrow | 2.59622136 |
| 19 | MP0008057_abnormal_DNA_replication | 2.41832901 |
| 20 | MP0005464_abnormal_platelet_physiology | 2.32369882 |
| 21 | MP0004808_abnormal_hematopoietic_stem | 2.31691934 |
| 22 | MP0000716_abnormal_immune_system | 2.29552439 |
| 23 | MP0002166_altered_tumor_susceptibility | 2.29483302 |
| 24 | MP0002419_abnormal_innate_immunity | 2.26817231 |
| 25 | MP0000689_abnormal_spleen_morphology | 2.20767818 |
| 26 | MP0002006_tumorigenesis | 2.16994790 |
| 27 | MP0006082_CNS_inflammation | 2.12448336 |
| 28 | MP0001853_heart_inflammation | 2.12370801 |
| 29 | MP0001545_abnormal_hematopoietic_system | 2.08954195 |
| 30 | MP0005397_hematopoietic_system_phenotyp | 2.08954195 |
| 31 | MP0002722_abnormal_immune_system | 2.07804928 |
| 32 | MP0002405_respiratory_system_inflammati | 2.07468540 |
| 33 | MP0009333_abnormal_splenocyte_physiolog | 2.07233280 |
| 34 | MP0001873_stomach_inflammation | 2.03010541 |
| 35 | MP0010155_abnormal_intestine_physiology | 2.01563698 |
| 36 | MP0003724_increased_susceptibility_to | 1.98788181 |
| 37 | MP0002429_abnormal_blood_cell | 1.96671413 |
| 38 | MP0003866_abnormal_defecation | 1.93894612 |
| 39 | MP0000703_abnormal_thymus_morphology | 1.80094537 |
| 40 | MP0002163_abnormal_gland_morphology | 1.74373457 |
| 41 | MP0000490_abnormal_crypts_of | 1.73368401 |
| 42 | MP0005174_abnormal_tail_pigmentation | 1.72355334 |
| 43 | MP0005075_abnormal_melanosome_morpholog | 1.67185514 |
| 44 | MP0001845_abnormal_inflammatory_respons | 1.65624250 |
| 45 | MP0000465_gastrointestinal_hemorrhage | 1.58189137 |
| 46 | MP0000569_abnormal_digit_pigmentation | 1.53301434 |
| 47 | MP0008469_abnormal_protein_level | 1.31946715 |
| 48 | MP0008007_abnormal_cellular_replicative | 1.30151851 |
| 49 | MP0004947_skin_inflammation | 1.29713074 |
| 50 | MP0000858_altered_metastatic_potential | 1.24075389 |
| 51 | MP0010094_abnormal_chromosome_stability | 1.22503651 |
| 52 | MP0003448_altered_tumor_morphology | 1.22298668 |
| 53 | MP0002138_abnormal_hepatobiliary_system | 1.18243276 |
| 54 | MP0003303_peritoneal_inflammation | 1.16624088 |
| 55 | MP0001501_abnormal_sleep_pattern | 1.13919581 |
| 56 | MP0002019_abnormal_tumor_incidence | 1.13200706 |
| 57 | MP0004510_myositis | 1.12589179 |
| 58 | MP0002095_abnormal_skin_pigmentation | 1.10720336 |
| 59 | MP0002277_abnormal_respiratory_mucosa | 1.09613140 |
| 60 | MP0003300_gastrointestinal_ulcer | 1.09214723 |
| 61 | MP0008058_abnormal_DNA_repair | 1.06874373 |
| 62 | MP0008872_abnormal_physiological_respon | 1.03780842 |
| 63 | MP0002693_abnormal_pancreas_physiology | 1.02798068 |
| 64 | MP0003693_abnormal_embryo_hatching | 1.02103113 |
| 65 | MP0001919_abnormal_reproductive_system | 1.01416165 |
| 66 | MP0009764_decreased_sensitivity_to | 0.99009099 |
| 67 | MP0003787_abnormal_imprinting | 0.97561076 |
| 68 | MP0002933_joint_inflammation | 0.96143979 |
| 69 | MP0005310_abnormal_salivary_gland | 0.94810235 |
| 70 | MP0005379_endocrine/exocrine_gland_phen | 0.93414134 |
| 71 | MP0005645_abnormal_hypothalamus_physiol | 0.93398845 |
| 72 | MP0001533_abnormal_skeleton_physiology | 0.92279575 |
| 73 | MP0003646_muscle_fatigue | 0.91868564 |
| 74 | MP0003077_abnormal_cell_cycle | 0.87957534 |
| 75 | MP0001851_eye_inflammation | 0.87357450 |
| 76 | MP0000015_abnormal_ear_pigmentation | 0.86482009 |
| 77 | MP0003868_abnormal_feces_composition | 0.85413905 |
| 78 | MP0009278_abnormal_bone_marrow | 0.85155936 |
| 79 | MP0001968_abnormal_touch/_nociception | 0.84062021 |
| 80 | MP0009763_increased_sensitivity_to | 0.83552727 |
| 81 | MP0010307_abnormal_tumor_latency | 0.83490163 |
| 82 | MP0002009_preneoplasia | 0.81127943 |
| 83 | MP0003943_abnormal_hepatobiliary_system | 0.79820163 |
| 84 | MP0000343_altered_response_to | 0.78146658 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.77628024 |
| 86 | MP0002132_abnormal_respiratory_system | 0.77197003 |
| 87 | MP0003172_abnormal_lysosome_physiology | 0.77024865 |
| 88 | MP0008877_abnormal_DNA_methylation | 0.76913537 |
| 89 | MP0001348_abnormal_lacrimal_gland | 0.76203098 |
| 90 | MP0001663_abnormal_digestive_system | 0.76031870 |
| 91 | MP0006054_spinal_hemorrhage | 0.74001789 |
| 92 | MP0002102_abnormal_ear_morphology | 0.73430866 |
| 93 | MP0000313_abnormal_cell_death | 0.72874419 |
| 94 | MP0001986_abnormal_taste_sensitivity | 0.72347150 |
| 95 | MP0002234_abnormal_pharynx_morphology | 0.72246974 |
| 96 | MP0002877_abnormal_melanocyte_morpholog | 0.71989146 |
| 97 | MP0004742_abnormal_vestibular_system | 0.71894972 |
| 98 | MP0003656_abnormal_erythrocyte_physiolo | 0.70544641 |
| 99 | MP0003186_abnormal_redox_activity | 0.67684178 |
| 100 | MP0003045_fibrosis | 0.67448100 |
| 101 | MP0002928_abnormal_bile_duct | 0.66474837 |
| 102 | MP0002736_abnormal_nociception_after | 0.66446115 |
| 103 | MP0002876_abnormal_thyroid_physiology | 0.64549708 |
| 104 | MP0001765_abnormal_ion_homeostasis | 0.61915301 |
| 105 | MP0004145_abnormal_muscle_electrophysio | 0.58790379 |
| 106 | MP0001502_abnormal_circadian_rhythm | 0.56811612 |
| 107 | MP0003191_abnormal_cellular_cholesterol | 0.56595778 |
| 108 | MP0002168_other_aberrant_phenotype | 0.56320615 |
| 109 | MP0000613_abnormal_salivary_gland | 0.55872008 |
| 110 | MP0005166_decreased_susceptibility_to | 0.55750919 |
| 111 | MP0008873_increased_physiological_sensi | 0.55284576 |
| 112 | MP0004957_abnormal_blastocyst_morpholog | 0.55261397 |
| 113 | MP0009643_abnormal_urine_homeostasis | 0.54259473 |
| 114 | MP0004381_abnormal_hair_follicle | 0.53714204 |
| 115 | MP0002998_abnormal_bone_remodeling | 0.53684908 |
| 116 | MP0003111_abnormal_nucleus_morphology | 0.52906869 |
| 117 | MP0000477_abnormal_intestine_morphology | 0.52787916 |
| 118 | MP0004142_abnormal_muscle_tone | 0.52537504 |
| 119 | MP0002136_abnormal_kidney_physiology | 0.52339964 |
| 120 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.52305272 |
| 121 | MP0003075_altered_response_to | 0.50808812 |
| 122 | MP0008995_early_reproductive_senescence | 0.49246391 |
| 123 | MP0005636_abnormal_mineral_homeostasis | 0.49058484 |
| 124 | MP0003786_premature_aging | 0.47695691 |
| 125 | MP0000372_irregular_coat_pigmentation | 0.47677313 |
| 126 | MP0006292_abnormal_olfactory_placode | 0.47299406 |
| 127 | MP0005408_hypopigmentation | 0.46835002 |
| 128 | MP0000371_diluted_coat_color | 0.46798940 |
| 129 | MP0000920_abnormal_myelination | 0.46612959 |
| 130 | MP0005389_reproductive_system_phenotype | 0.46552250 |
| 131 | MP0003183_abnormal_peptide_metabolism | 0.46416283 |
| 132 | MP0005165_increased_susceptibility_to | 0.43490580 |
| 133 | MP0001905_abnormal_dopamine_level | 0.42780242 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.31669699 |
| 2 | Myositis (HP:0100614) | 5.14380550 |
| 3 | Chronic otitis media (HP:0000389) | 4.60608696 |
| 4 | Thrombocytosis (HP:0001894) | 4.49892440 |
| 5 | IgM deficiency (HP:0002850) | 4.25720235 |
| 6 | Recurrent abscess formation (HP:0002722) | 4.19986597 |
| 7 | Recurrent bronchitis (HP:0002837) | 4.11217437 |
| 8 | Recurrent bacterial skin infections (HP:0005406) | 3.79872215 |
| 9 | Recurrent viral infections (HP:0004429) | 3.78569466 |
| 10 | Retrobulbar optic neuritis (HP:0100654) | 3.74140726 |
| 11 | Optic neuritis (HP:0100653) | 3.74140726 |
| 12 | T lymphocytopenia (HP:0005403) | 3.67807791 |
| 13 | Recurrent fungal infections (HP:0002841) | 3.65525958 |
| 14 | Aplastic anemia (HP:0001915) | 3.63907991 |
| 15 | Orchitis (HP:0100796) | 3.56157242 |
| 16 | Abnormality of T cells (HP:0002843) | 3.51380278 |
| 17 | Abnormality of T cell number (HP:0011839) | 3.49265467 |
| 18 | IgG deficiency (HP:0004315) | 3.47333255 |
| 19 | Meningitis (HP:0001287) | 3.46371181 |
| 20 | Eczematoid dermatitis (HP:0000976) | 3.43195477 |
| 21 | Panhypogammaglobulinemia (HP:0003139) | 3.39953177 |
| 22 | Abnormality of the prostate (HP:0008775) | 3.28423725 |
| 23 | Joint swelling (HP:0001386) | 3.26577428 |
| 24 | Gangrene (HP:0100758) | 3.26162902 |
| 25 | Agammaglobulinemia (HP:0004432) | 3.23918788 |
| 26 | Encephalitis (HP:0002383) | 3.18808161 |
| 27 | Stomatitis (HP:0010280) | 3.15627937 |
| 28 | Abnormality of B cell number (HP:0010975) | 3.11793587 |
| 29 | B lymphocytopenia (HP:0010976) | 3.11793587 |
| 30 | Abnormality of T cell physiology (HP:0011840) | 3.07752404 |
| 31 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.07481402 |
| 32 | Recurrent cutaneous fungal infections (HP:0011370) | 3.07481402 |
| 33 | Vasculitis (HP:0002633) | 3.00711378 |
| 34 | Prolonged bleeding time (HP:0003010) | 3.00400098 |
| 35 | Recurrent skin infections (HP:0001581) | 2.98163330 |
| 36 | Eosinophilia (HP:0001880) | 2.96642585 |
| 37 | Papilledema (HP:0001085) | 2.95066723 |
| 38 | Amaurosis fugax (HP:0100576) | 2.93136641 |
| 39 | Cellulitis (HP:0100658) | 2.93062272 |
| 40 | Mediastinal lymphadenopathy (HP:0100721) | 2.92727749 |
| 41 | Autoimmune hemolytic anemia (HP:0001890) | 2.91375950 |
| 42 | Petechiae (HP:0000967) | 2.89768097 |
| 43 | Epistaxis (HP:0000421) | 2.87958563 |
| 44 | Thyroiditis (HP:0100646) | 2.84759494 |
| 45 | Arterial thrombosis (HP:0004420) | 2.83361397 |
| 46 | Severe combined immunodeficiency (HP:0004430) | 2.80390021 |
| 47 | Abnormality of macrophages (HP:0004311) | 2.79124756 |
| 48 | Lymphoma (HP:0002665) | 2.78836809 |
| 49 | Lymphopenia (HP:0001888) | 2.78440570 |
| 50 | Pulmonary embolism (HP:0002204) | 2.77488588 |
| 51 | Birth length less than 3rd percentile (HP:0003561) | 2.76453387 |
| 52 | Chronic diarrhea (HP:0002028) | 2.72320950 |
| 53 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.70832591 |
| 54 | Keratoconjunctivitis sicca (HP:0001097) | 2.70475276 |
| 55 | Acute myeloid leukemia (HP:0004808) | 2.67800060 |
| 56 | Hypoplasia of the thymus (HP:0000778) | 2.66397092 |
| 57 | Obstructive lung disease (HP:0006536) | 2.66306188 |
| 58 | Chronic obstructive pulmonary disease (HP:0006510) | 2.66306188 |
| 59 | Autoimmune thrombocytopenia (HP:0001973) | 2.64130563 |
| 60 | Abnormality of the fingertips (HP:0001211) | 2.63842580 |
| 61 | Muscle fiber atrophy (HP:0100295) | 2.63174835 |
| 62 | Neonatal hypoglycemia (HP:0001998) | 2.63039223 |
| 63 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.61296673 |
| 64 | Recurrent sinusitis (HP:0011108) | 2.57652447 |
| 65 | Nasal polyposis (HP:0100582) | 2.55122423 |
| 66 | Granulocytopenia (HP:0001913) | 2.55002451 |
| 67 | Gingival bleeding (HP:0000225) | 2.54664504 |
| 68 | Combined immunodeficiency (HP:0005387) | 2.48702694 |
| 69 | IgA deficiency (HP:0002720) | 2.46671251 |
| 70 | Type 2 muscle fiber atrophy (HP:0003554) | 2.45783971 |
| 71 | Keratoconjunctivitis (HP:0001096) | 2.44523577 |
| 72 | Reticulocytopenia (HP:0001896) | 2.41915682 |
| 73 | Abnormal number of erythroid precursors (HP:0012131) | 2.41709742 |
| 74 | Anorexia (HP:0002039) | 2.41335393 |
| 75 | Asplenia (HP:0001746) | 2.41077334 |
| 76 | Hemoptysis (HP:0002105) | 2.40590547 |
| 77 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.39088538 |
| 78 | Keratitis (HP:0000491) | 2.38329408 |
| 79 | Chest pain (HP:0100749) | 2.37681487 |
| 80 | Pulmonary infiltrates (HP:0002113) | 2.37274604 |
| 81 | Gastrointestinal stroma tumor (HP:0100723) | 2.34401009 |
| 82 | Polyneuropathy (HP:0001271) | 2.33426983 |
| 83 | Abnormality of the nasal mucosa (HP:0000433) | 2.32944278 |
| 84 | Reduced antithrombin III activity (HP:0001976) | 2.31580809 |
| 85 | Leukocytosis (HP:0001974) | 2.31441644 |
| 86 | Abnormality of the pericardium (HP:0001697) | 2.27578862 |
| 87 | Hypoproteinemia (HP:0003075) | 2.27154481 |
| 88 | Inflammation of the large intestine (HP:0002037) | 2.24772156 |
| 89 | Chronic sinusitis (HP:0011109) | 2.24351738 |
| 90 | Glomerulopathy (HP:0100820) | 2.23659897 |
| 91 | Acute hepatic failure (HP:0006554) | 2.22712557 |
| 92 | Gastrointestinal inflammation (HP:0004386) | 2.20748919 |
| 93 | Bronchitis (HP:0012387) | 2.20635631 |
| 94 | Ureteral stenosis (HP:0000071) | 2.17994413 |
| 95 | Abnormality of eosinophils (HP:0001879) | 2.16469982 |
| 96 | Myelodysplasia (HP:0002863) | 2.14908646 |
| 97 | Acute lymphatic leukemia (HP:0006721) | 2.14457135 |
| 98 | Hypergammaglobulinemia (HP:0010702) | 2.13955113 |
| 99 | Increased IgM level (HP:0003496) | 2.12555054 |
| 100 | Gastrointestinal infarctions (HP:0005244) | 2.12463819 |
| 101 | Interstitial pulmonary disease (HP:0006530) | 2.12324900 |
| 102 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.11517019 |
| 103 | Type I transferrin isoform profile (HP:0003642) | 2.11121591 |
| 104 | Pustule (HP:0200039) | 2.10412023 |
| 105 | Ureteral obstruction (HP:0006000) | 2.10165030 |
| 106 | 3-Methylglutaconic aciduria (HP:0003535) | 2.05339326 |
| 107 | Hypoalbuminemia (HP:0003073) | 2.04825233 |
| 108 | Abnormal albumin level (HP:0012116) | 2.04825233 |
| 109 | Pancytopenia (HP:0001876) | 2.04551876 |
| 110 | Basal ganglia calcification (HP:0002135) | 2.04040551 |
| 111 | Thrombophlebitis (HP:0004418) | 2.00590522 |
| 112 | Spontaneous hematomas (HP:0007420) | 2.00053300 |
| 113 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.99153254 |
| 114 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.96876028 |
| 115 | Abnormality of the pleura (HP:0002103) | 1.95917356 |
| 116 | Pancreatitis (HP:0001733) | 1.94962653 |
| 117 | Microcytic anemia (HP:0001935) | 1.93591843 |
| 118 | Skin rash (HP:0000988) | 1.92028868 |
| 119 | Recurrent pneumonia (HP:0006532) | 1.91226260 |
| 120 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.91020138 |
| 121 | Congenital stationary night blindness (HP:0007642) | 1.89759974 |
| 122 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.89546899 |
| 123 | Hemiplegia (HP:0002301) | 1.88594428 |
| 124 | Pulmonary fibrosis (HP:0002206) | 1.80673275 |
| 125 | Paresthesia (HP:0003401) | 1.80196282 |
| 126 | Renal cortical cysts (HP:0000803) | 1.77565879 |
| 127 | Hepatosplenomegaly (HP:0001433) | 1.75789883 |
| 128 | Abnormality of male internal genitalia (HP:0000022) | 1.75129976 |
| 129 | Increased hepatocellular lipid droplets (HP:0006565) | 1.72147523 |
| 130 | Alveolar cell carcinoma (HP:0006519) | 1.71048154 |
| 131 | Oral leukoplakia (HP:0002745) | 1.67785072 |
| 132 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.66820487 |
| 133 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.66820487 |
| 134 | Increased intramyocellular lipid droplets (HP:0012240) | 1.66017824 |
| 135 | Lipid accumulation in hepatocytes (HP:0006561) | 1.65708812 |
| 136 | Abnormality of the pons (HP:0007361) | 1.65194923 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 5.39198805 |
| 2 | TXK | 4.05192720 |
| 3 | MAP4K1 | 3.97767906 |
| 4 | STK16 | 3.38646591 |
| 5 | KIT | 3.11117254 |
| 6 | FLT3 | 2.87115724 |
| 7 | JAK3 | 2.44637868 |
| 8 | TEC | 2.44061603 |
| 9 | IRAK4 | 2.39914762 |
| 10 | BTK | 2.22367034 |
| 11 | ZAP70 | 2.15301907 |
| 12 | MAP3K14 | 2.13434880 |
| 13 | TBK1 | 1.85292561 |
| 14 | IKBKE | 1.81830263 |
| 15 | SYK | 1.79401618 |
| 16 | EPHA3 | 1.76754444 |
| 17 | CSF1R | 1.74506597 |
| 18 | TNIK | 1.70799837 |
| 19 | ITK | 1.64075301 |
| 20 | BLK | 1.62548146 |
| 21 | TYK2 | 1.58168772 |
| 22 | PIM2 | 1.56271686 |
| 23 | IRAK3 | 1.49946559 |
| 24 | TESK1 | 1.49029032 |
| 25 | EEF2K | 1.47287757 |
| 26 | SCYL2 | 1.45652308 |
| 27 | NLK | 1.40914307 |
| 28 | IKBKB | 1.40610069 |
| 29 | MAP2K3 | 1.38607176 |
| 30 | LCK | 1.36169285 |
| 31 | WNK4 | 1.34089338 |
| 32 | MAP3K12 | 1.33157851 |
| 33 | MAP4K2 | 1.29452455 |
| 34 | NUAK1 | 1.27849390 |
| 35 | FES | 1.27677673 |
| 36 | CLK1 | 1.26930257 |
| 37 | TGFBR1 | 1.24429255 |
| 38 | PIM1 | 1.23376206 |
| 39 | WEE1 | 1.21546967 |
| 40 | JAK1 | 1.20820355 |
| 41 | TAOK3 | 1.19689877 |
| 42 | PIK3CG | 1.17009141 |
| 43 | ADRBK2 | 1.13052198 |
| 44 | LYN | 1.08143431 |
| 45 | CAMKK2 | 1.06447574 |
| 46 | MUSK | 0.99239186 |
| 47 | SIK3 | 0.95793138 |
| 48 | RPS6KB2 | 0.95144408 |
| 49 | HCK | 0.95089713 |
| 50 | BMPR2 | 0.93753982 |
| 51 | ACVR1B | 0.93391372 |
| 52 | VRK1 | 0.87913683 |
| 53 | CDK19 | 0.87789511 |
| 54 | CHUK | 0.87527343 |
| 55 | TYRO3 | 0.86046599 |
| 56 | GRK6 | 0.83576697 |
| 57 | RIPK4 | 0.83272010 |
| 58 | FRK | 0.83226047 |
| 59 | TGFBR2 | 0.82053545 |
| 60 | TSSK6 | 0.81689270 |
| 61 | STK39 | 0.80169882 |
| 62 | PKN2 | 0.79657706 |
| 63 | FGFR4 | 0.79258886 |
| 64 | TESK2 | 0.78781306 |
| 65 | MST4 | 0.78541222 |
| 66 | STK10 | 0.77910875 |
| 67 | MATK | 0.77843402 |
| 68 | MAP3K13 | 0.72625755 |
| 69 | VRK2 | 0.71870579 |
| 70 | TLK1 | 0.70866133 |
| 71 | BCKDK | 0.70803951 |
| 72 | NEK9 | 0.70381656 |
| 73 | CSK | 0.68353811 |
| 74 | EIF2AK3 | 0.67593133 |
| 75 | BUB1 | 0.67300049 |
| 76 | TAOK2 | 0.66932165 |
| 77 | FGFR3 | 0.66652772 |
| 78 | MAPKAPK5 | 0.65922653 |
| 79 | MARK3 | 0.65884075 |
| 80 | BRSK2 | 0.65723544 |
| 81 | MAP3K3 | 0.65241379 |
| 82 | OXSR1 | 0.63644803 |
| 83 | CCNB1 | 0.63414272 |
| 84 | MAPK11 | 0.58599356 |
| 85 | LRRK2 | 0.57542523 |
| 86 | TRPM7 | 0.55757165 |
| 87 | ATR | 0.55419642 |
| 88 | GRK1 | 0.54283856 |
| 89 | MAP2K6 | 0.54272247 |
| 90 | PASK | 0.53342718 |
| 91 | KDR | 0.52971792 |
| 92 | MKNK1 | 0.51971147 |
| 93 | ZAK | 0.51486347 |
| 94 | PDK1 | 0.51015489 |
| 95 | PRKCH | 0.50316789 |
| 96 | CDK8 | 0.50291223 |
| 97 | TNK2 | 0.50132735 |
| 98 | JAK2 | 0.48678051 |
| 99 | GRK7 | 0.48579024 |
| 100 | IRAK1 | 0.47588563 |
| 101 | CDK4 | 0.47302124 |
| 102 | ALK | 0.45990296 |
| 103 | FYN | 0.44393729 |
| 104 | DAPK1 | 0.43826652 |
| 105 | EIF2AK1 | 0.42815221 |
| 106 | MAPK13 | 0.42568672 |
| 107 | MAPK4 | 0.42106771 |
| 108 | RPS6KA4 | 0.41952003 |
| 109 | MAPKAPK3 | 0.41891323 |
| 110 | IGF1R | 0.41408384 |
| 111 | DYRK3 | 0.39604503 |
| 112 | CDK7 | 0.38566585 |
| 113 | MAP3K6 | 0.38476853 |
| 114 | RPS6KA6 | 0.36548434 |
| 115 | MAPKAPK2 | 0.36483906 |
| 116 | HIPK2 | 0.36276789 |
| 117 | STK4 | 0.35107920 |
| 118 | PDGFRB | 0.34203677 |
| 119 | PIK3CA | 0.33805322 |
| 120 | RPS6KA5 | 0.33509701 |
| 121 | MYLK | 0.32705792 |
| 122 | EIF2AK2 | 0.32702843 |
| 123 | PRKCQ | 0.32238994 |
| 124 | MAP3K11 | 0.32043364 |
| 125 | CDK9 | 0.30972017 |
| 126 | CDC7 | 0.30662698 |
| 127 | SRPK1 | 0.29762727 |
| 128 | RPS6KB1 | 0.29690026 |
| 129 | EPHB1 | 0.29177827 |
| 130 | PRKCD | 0.29124442 |
| 131 | MKNK2 | 0.28974923 |
| 132 | PAK3 | 0.28125736 |
| 133 | INSR | 0.25096473 |
| 134 | STK38 | 0.24428982 |
| 135 | CAMKK1 | 0.22444687 |
| 136 | CAMK2A | 0.21696535 |
| 137 | DAPK2 | 0.18877478 |
| 138 | PRKCA | 0.18623078 |
| 139 | EGFR | 0.18113758 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Allograft rejection_Homo sapiens_hsa05330 | 3.63536904 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.62018252 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.32765682 |
| 4 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.92819098 |
| 5 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.75302857 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.59225678 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.46968845 |
| 8 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.43708550 |
| 9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.37078524 |
| 10 | Measles_Homo sapiens_hsa05162 | 2.36625061 |
| 11 | Leishmaniasis_Homo sapiens_hsa05140 | 2.31617701 |
| 12 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.28372677 |
| 13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.17145780 |
| 14 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.02805679 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.01116446 |
| 16 | Mismatch repair_Homo sapiens_hsa03430 | 1.94426951 |
| 17 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.93853199 |
| 18 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.91691336 |
| 19 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.84166610 |
| 20 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.81752351 |
| 21 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.78278435 |
| 22 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.68917423 |
| 23 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.60712992 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.60407517 |
| 25 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.52342189 |
| 26 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.49822472 |
| 27 | Legionellosis_Homo sapiens_hsa05134 | 1.41299061 |
| 28 | Homologous recombination_Homo sapiens_hsa03440 | 1.38467621 |
| 29 | Asthma_Homo sapiens_hsa05310 | 1.37396612 |
| 30 | Influenza A_Homo sapiens_hsa05164 | 1.35091038 |
| 31 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.34882082 |
| 32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.34405791 |
| 33 | Spliceosome_Homo sapiens_hsa03040 | 1.29008542 |
| 34 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.28873436 |
| 35 | Pertussis_Homo sapiens_hsa05133 | 1.24957830 |
| 36 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.21135884 |
| 37 | Malaria_Homo sapiens_hsa05144 | 1.20266157 |
| 38 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.15711278 |
| 39 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.09686359 |
| 40 | Viral myocarditis_Homo sapiens_hsa05416 | 1.09461967 |
| 41 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.09121035 |
| 42 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.08934963 |
| 43 | Hepatitis B_Homo sapiens_hsa05161 | 1.07539214 |
| 44 | Shigellosis_Homo sapiens_hsa05131 | 1.07470882 |
| 45 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.06671442 |
| 46 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.02068795 |
| 47 | RNA polymerase_Homo sapiens_hsa03020 | 1.01551667 |
| 48 | Platelet activation_Homo sapiens_hsa04611 | 0.98956897 |
| 49 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.98911523 |
| 50 | RNA degradation_Homo sapiens_hsa03018 | 0.97577279 |
| 51 | Tuberculosis_Homo sapiens_hsa05152 | 0.96806486 |
| 52 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.96364147 |
| 53 | Parkinsons disease_Homo sapiens_hsa05012 | 0.95049949 |
| 54 | Apoptosis_Homo sapiens_hsa04210 | 0.94403639 |
| 55 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.93866735 |
| 56 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.92623098 |
| 57 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.92456646 |
| 58 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.91750798 |
| 59 | Proteasome_Homo sapiens_hsa03050 | 0.91269329 |
| 60 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.89049156 |
| 61 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.88771660 |
| 62 | Salmonella infection_Homo sapiens_hsa05132 | 0.87964516 |
| 63 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.87436492 |
| 64 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.82354174 |
| 65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.80551434 |
| 66 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.77800087 |
| 67 | Other glycan degradation_Homo sapiens_hsa00511 | 0.77031197 |
| 68 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.74872209 |
| 69 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.71998905 |
| 70 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70677236 |
| 71 | Cell cycle_Homo sapiens_hsa04110 | 0.69529049 |
| 72 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.67385565 |
| 73 | Hepatitis C_Homo sapiens_hsa05160 | 0.66770239 |
| 74 | Phototransduction_Homo sapiens_hsa04744 | 0.64907942 |
| 75 | Protein export_Homo sapiens_hsa03060 | 0.61935278 |
| 76 | HTLV-I infection_Homo sapiens_hsa05166 | 0.60231588 |
| 77 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59604308 |
| 78 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58044031 |
| 79 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.56661952 |
| 80 | RNA transport_Homo sapiens_hsa03013 | 0.56588844 |
| 81 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.55876278 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51272672 |
| 83 | Thyroid cancer_Homo sapiens_hsa05216 | 0.50724294 |
| 84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49855495 |
| 85 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48143783 |
| 86 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.47155180 |
| 87 | Basal transcription factors_Homo sapiens_hsa03022 | 0.46402098 |
| 88 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43732381 |
| 89 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.43392573 |
| 90 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.42062533 |
| 91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41364159 |
| 92 | Purine metabolism_Homo sapiens_hsa00230 | 0.40552747 |
| 93 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.40411630 |
| 94 | Alzheimers disease_Homo sapiens_hsa05010 | 0.40147611 |
| 95 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39447574 |
| 96 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.38698699 |
| 97 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.37975465 |
| 98 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.37916470 |
| 99 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.36652056 |
| 100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.35843997 |
| 101 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.35423040 |
| 102 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.34956993 |
| 103 | Huntingtons disease_Homo sapiens_hsa05016 | 0.32941080 |
| 104 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.28903672 |
| 105 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.28700011 |
| 106 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27579419 |
| 107 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.26858154 |
| 108 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.26652099 |
| 109 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.25259681 |
| 110 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.24766823 |
| 111 | Colorectal cancer_Homo sapiens_hsa05210 | 0.24737477 |
| 112 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.23383676 |
| 113 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.20860313 |
| 114 | Peroxisome_Homo sapiens_hsa04146 | 0.18522211 |
| 115 | Olfactory transduction_Homo sapiens_hsa04740 | 0.18443268 |
| 116 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.17795987 |
| 117 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.17398091 |
| 118 | Circadian rhythm_Homo sapiens_hsa04710 | 0.17264597 |
| 119 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.17110539 |
| 120 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.10643992 |
| 121 | Endocytosis_Homo sapiens_hsa04144 | 0.09829723 |
| 122 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.09561235 |
| 123 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.06190649 |
| 124 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.05527511 |
| 125 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.05041512 |
| 126 | ABC transporters_Homo sapiens_hsa02010 | 0.03841450 |
| 127 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.02791860 |

