

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.90808022 |
| 2 | negative T cell selection (GO:0043383) | 6.88325685 |
| 3 | negative thymic T cell selection (GO:0045060) | 6.67645704 |
| 4 | positive thymic T cell selection (GO:0045059) | 6.39842831 |
| 5 | positive T cell selection (GO:0043368) | 6.25964379 |
| 6 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 5.98084961 |
| 7 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.98027284 |
| 8 | cellular response to interleukin-15 (GO:0071350) | 5.90743775 |
| 9 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.85335495 |
| 10 | negative regulation of cell killing (GO:0031342) | 5.85335495 |
| 11 | thymic T cell selection (GO:0045061) | 5.71670406 |
| 12 | response to interleukin-15 (GO:0070672) | 5.71667790 |
| 13 | interferon-gamma production (GO:0032609) | 5.60678551 |
| 14 | T cell selection (GO:0045058) | 5.58226672 |
| 15 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.56874797 |
| 16 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.33482858 |
| 17 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.09424032 |
| 18 | T cell migration (GO:0072678) | 5.05977244 |
| 19 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.92579114 |
| 20 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.86009771 |
| 21 | regulation of gamma-delta T cell activation (GO:0046643) | 4.84578316 |
| 22 | activated T cell proliferation (GO:0050798) | 4.75140598 |
| 23 | positive regulation of granulocyte differentiation (GO:0030854) | 4.71578188 |
| 24 | leukocyte aggregation (GO:0070486) | 4.69971135 |
| 25 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.65461851 |
| 26 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.62664422 |
| 27 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.62664422 |
| 28 | regulation of regulatory T cell differentiation (GO:0045589) | 4.60963304 |
| 29 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.57716764 |
| 30 | regulation of T cell tolerance induction (GO:0002664) | 4.57072969 |
| 31 | negative regulation of T cell mediated immunity (GO:0002710) | 4.56024633 |
| 32 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.55632508 |
| 33 | T cell receptor signaling pathway (GO:0050852) | 4.54465856 |
| 34 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.46636296 |
| 35 | positive regulation of interleukin-2 production (GO:0032743) | 4.42189740 |
| 36 | T cell costimulation (GO:0031295) | 4.41927439 |
| 37 | lymphocyte costimulation (GO:0031294) | 4.37836185 |
| 38 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.32145616 |
| 39 | tolerance induction (GO:0002507) | 4.24529932 |
| 40 | positive regulation of B cell differentiation (GO:0045579) | 4.08728901 |
| 41 | B cell receptor signaling pathway (GO:0050853) | 4.03632106 |
| 42 | positive regulation of isotype switching (GO:0045830) | 4.03529302 |
| 43 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.01283832 |
| 44 | regulation of isotype switching (GO:0045191) | 4.00386114 |
| 45 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.95640492 |
| 46 | positive regulation of DNA recombination (GO:0045911) | 3.82228658 |
| 47 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.72442002 |
| 48 | natural killer cell differentiation (GO:0001779) | 3.65670320 |
| 49 | positive regulation of humoral immune response (GO:0002922) | 3.61355925 |
| 50 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.59822593 |
| 51 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.58779503 |
| 52 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.57669611 |
| 53 | positive regulation of B cell mediated immunity (GO:0002714) | 3.57669611 |
| 54 | regulation of B cell mediated immunity (GO:0002712) | 3.54720323 |
| 55 | regulation of interleukin-2 production (GO:0032663) | 3.54385506 |
| 56 | regulation of B cell differentiation (GO:0045577) | 3.53744515 |
| 57 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.53009883 |
| 58 | regulation of immunoglobulin production (GO:0002637) | 3.50398477 |
| 59 | positive regulation of tolerance induction (GO:0002645) | 3.48763413 |
| 60 | alpha-beta T cell differentiation (GO:0046632) | 3.44138754 |
| 61 | hepatocyte apoptotic process (GO:0097284) | 3.43646046 |
| 62 | modulation by symbiont of host defense response (GO:0052031) | 3.42620542 |
| 63 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.42620542 |
| 64 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.42620542 |
| 65 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.42620542 |
| 66 | modulation by symbiont of host immune response (GO:0052553) | 3.42620542 |
| 67 | positive regulation by symbiont of host defense response (GO:0052509) | 3.42620542 |
| 68 | mast cell activation (GO:0045576) | 3.42125779 |
| 69 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.38142580 |
| 70 | positive regulation of immunoglobulin production (GO:0002639) | 3.38007669 |
| 71 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.37505567 |
| 72 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.37505567 |
| 73 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.37290058 |
| 74 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.37290058 |
| 75 | alpha-beta T cell activation (GO:0046631) | 3.36288103 |
| 76 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.32849914 |
| 77 | regulation of tolerance induction (GO:0002643) | 3.32376959 |
| 78 | B cell proliferation (GO:0042100) | 3.28281880 |
| 79 | positive regulation of interleukin-4 production (GO:0032753) | 3.27595101 |
| 80 | T cell homeostasis (GO:0043029) | 3.27442773 |
| 81 | negative regulation of interleukin-12 production (GO:0032695) | 3.20699321 |
| 82 | regulation of granulocyte differentiation (GO:0030852) | 3.20049932 |
| 83 | regulation of alpha-beta T cell activation (GO:0046634) | 3.19780126 |
| 84 | T cell differentiation (GO:0030217) | 3.18981460 |
| 85 | regulation of B cell proliferation (GO:0030888) | 3.17611637 |
| 86 | positive regulation of B cell proliferation (GO:0030890) | 3.16298554 |
| 87 | T cell proliferation (GO:0042098) | 3.13786463 |
| 88 | Peyers patch development (GO:0048541) | 3.11805823 |
| 89 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.11805823 |
| 90 | cellular extravasation (GO:0045123) | 3.10635119 |
| 91 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.08651192 |
| 92 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.06705779 |
| 93 | mature B cell differentiation (GO:0002335) | 3.06366298 |
| 94 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 3.06191323 |
| 95 | natural killer cell activation (GO:0030101) | 3.06084837 |
| 96 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.05747729 |
| 97 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.04593643 |
| 98 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.04208451 |
| 99 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.03819521 |
| 100 | T-helper cell differentiation (GO:0042093) | 3.03819521 |
| 101 | negative regulation of adaptive immune response (GO:0002820) | 3.01980157 |
| 102 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.00934783 |
| 103 | lymphocyte homeostasis (GO:0002260) | 3.00712675 |
| 104 | myeloid dendritic cell activation (GO:0001773) | 3.00513143 |
| 105 | B cell homeostasis (GO:0001782) | 2.99846586 |
| 106 | cellular response to type I interferon (GO:0071357) | 2.99508765 |
| 107 | type I interferon signaling pathway (GO:0060337) | 2.99508765 |
| 108 | response to type I interferon (GO:0034340) | 2.98465837 |
| 109 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.97469064 |
| 110 | regulation of interleukin-4 production (GO:0032673) | 2.97449975 |
| 111 | response to muramyl dipeptide (GO:0032495) | 2.97370612 |
| 112 | negative regulation of B cell proliferation (GO:0030889) | 2.95860742 |
| 113 | detection of other organism (GO:0098543) | 2.95222525 |
| 114 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.94953746 |
| 115 | NIK/NF-kappaB signaling (GO:0038061) | 2.94717830 |
| 116 | positive regulation of B cell activation (GO:0050871) | 2.92516928 |
| 117 | regulation of chronic inflammatory response (GO:0002676) | 2.90015038 |
| 118 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.89995369 |
| 119 | regulation of lymphocyte mediated immunity (GO:0002706) | 2.88387947 |
| 120 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.88018131 |
| 121 | positive regulation of T cell activation (GO:0050870) | 2.87875802 |
| 122 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 2.87572727 |
| 123 | alpha-beta T cell activation involved in immune response (GO:0002287) | 2.87572727 |
| 124 | T cell differentiation involved in immune response (GO:0002292) | 2.87572727 |
| 125 | regulation of cell killing (GO:0031341) | 2.86381265 |
| 126 | T cell activation (GO:0042110) | 2.86265756 |
| 127 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.85399320 |
| 128 | positive regulation of T cell proliferation (GO:0042102) | 2.84990293 |
| 129 | T cell lineage commitment (GO:0002360) | 2.84848458 |
| 130 | regulation of B cell activation (GO:0050864) | 2.84601015 |
| 131 | detection of bacterium (GO:0016045) | 2.84573576 |
| 132 | positive regulation of cell killing (GO:0031343) | 2.81558562 |
| 133 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.80851393 |
| 134 | positive regulation of alpha-beta T cell activation (GO:0046635) | 2.79919012 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.81376380 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.92688814 |
| 3 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.08572317 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.97982390 |
| 5 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.88773679 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.81655221 |
| 7 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.43918778 |
| 8 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.17650625 |
| 9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.15557718 |
| 10 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.82258421 |
| 11 | * MYB_26560356_Chip-Seq_TH2_Human | 2.70255663 |
| 12 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.67308762 |
| 13 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.64577840 |
| 14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.58758808 |
| 15 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.52789452 |
| 16 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.50622439 |
| 17 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.48697415 |
| 18 | MYB_26560356_Chip-Seq_TH1_Human | 2.27033578 |
| 19 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.21025875 |
| 20 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.18968296 |
| 21 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.09202416 |
| 22 | MAF_26560356_Chip-Seq_TH1_Human | 2.07742412 |
| 23 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.01951671 |
| 24 | GATA1_22025678_ChIP-Seq_K562_Human | 1.94315490 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.88109337 |
| 26 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.86317837 |
| 27 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.81406523 |
| 28 | UTX_26944678_Chip-Seq_JUKART_Human | 1.76373115 |
| 29 | MYC_22102868_ChIP-Seq_BL_Human | 1.70633274 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.68778974 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.62660843 |
| 32 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.59698956 |
| 33 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.59387286 |
| 34 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.58659518 |
| 35 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.52569454 |
| 36 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.51225600 |
| 37 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.50371086 |
| 38 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.45129344 |
| 39 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.44979136 |
| 40 | MAF_26560356_Chip-Seq_TH2_Human | 1.42057715 |
| 41 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.41246693 |
| 42 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39973348 |
| 43 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.39675930 |
| 44 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.39425950 |
| 45 | * TAF15_26573619_Chip-Seq_HEK293_Human | 1.38336004 |
| 46 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.36176751 |
| 47 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.35877725 |
| 48 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.35746211 |
| 49 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.34530849 |
| 50 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.34089845 |
| 51 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.33767586 |
| 52 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.29744891 |
| 53 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.27805477 |
| 54 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.24478924 |
| 55 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.22391834 |
| 56 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.21472589 |
| 57 | GATA3_26560356_Chip-Seq_TH2_Human | 1.20158709 |
| 58 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.20030398 |
| 59 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.19479285 |
| 60 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18710910 |
| 61 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.17777795 |
| 62 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.15220350 |
| 63 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13663057 |
| 64 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.13577794 |
| 65 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.11321609 |
| 66 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.10158463 |
| 67 | GATA1_19941826_ChIP-Seq_K562_Human | 1.08083101 |
| 68 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.07289892 |
| 69 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.06670303 |
| 70 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06341996 |
| 71 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.06075753 |
| 72 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.06030729 |
| 73 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05899332 |
| 74 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.04519585 |
| 75 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.02480366 |
| 76 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.02175022 |
| 77 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.01942217 |
| 78 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.01801901 |
| 79 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.00460716 |
| 80 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.00076177 |
| 81 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99180155 |
| 82 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.99070989 |
| 83 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.98138333 |
| 84 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.97507693 |
| 85 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.97457979 |
| 86 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.96762833 |
| 87 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.96513459 |
| 88 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.96385524 |
| 89 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95281889 |
| 90 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.95235043 |
| 91 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93952179 |
| 92 | GATA2_19941826_ChIP-Seq_K562_Human | 0.93419217 |
| 93 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.92585922 |
| 94 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92548438 |
| 95 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.91530869 |
| 96 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.91082031 |
| 97 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.90293769 |
| 98 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89742745 |
| 99 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.89530074 |
| 100 | SPI1_23127762_ChIP-Seq_K562_Human | 0.89210516 |
| 101 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.88423347 |
| 102 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.88163670 |
| 103 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.87756529 |
| 104 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.87724801 |
| 105 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.86778113 |
| 106 | P300_19829295_ChIP-Seq_ESCs_Human | 0.86142611 |
| 107 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.85520060 |
| 108 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.85025665 |
| 109 | * LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.84920520 |
| 110 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.84521361 |
| 111 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.84033464 |
| 112 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83888782 |
| 113 | PU1_27457419_Chip-Seq_LIVER_Mouse | 0.83589564 |
| 114 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83360418 |
| 115 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.82548433 |
| 116 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.82546844 |
| 117 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82092480 |
| 118 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.81953372 |
| 119 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.81228267 |
| 120 | GATA3_26560356_Chip-Seq_TH1_Human | 0.81193620 |
| 121 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81122591 |
| 122 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.81122591 |
| 123 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.80869686 |
| 124 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80806476 |
| 125 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.79904300 |
| 126 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.79213005 |
| 127 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.78754299 |
| 128 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.76287325 |
| 129 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.75814257 |
| 130 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.75790731 |
| 131 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.75671115 |
| 132 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.75547678 |
| 133 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.74744871 |
| 134 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.74730891 |
| 135 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73646194 |
| 136 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.73349644 |
| 137 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.73114049 |
| 138 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.71276980 |
| 139 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.70506922 |
| 140 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.70020787 |
| 141 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.68039319 |
| 142 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.66374208 |
| 143 | * TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.65666288 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 4.89584552 |
| 2 | MP0005671_abnormal_response_to | 4.54309440 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.94776038 |
| 4 | MP0001790_abnormal_immune_system | 3.80497467 |
| 5 | MP0005387_immune_system_phenotype | 3.80497467 |
| 6 | MP0001800_abnormal_humoral_immune | 3.74463622 |
| 7 | MP0005000_abnormal_immune_tolerance | 3.29490804 |
| 8 | MP0000685_abnormal_immune_system | 3.01712696 |
| 9 | MP0002723_abnormal_immune_serum | 2.97725869 |
| 10 | MP0002420_abnormal_adaptive_immunity | 2.91018481 |
| 11 | MP0002452_abnormal_antigen_presenting | 2.89406625 |
| 12 | MP0001819_abnormal_immune_cell | 2.84720393 |
| 13 | MP0002398_abnormal_bone_marrow | 2.59477982 |
| 14 | MP0001873_stomach_inflammation | 2.56870744 |
| 15 | MP0009785_altered_susceptibility_to | 2.56093267 |
| 16 | MP0006082_CNS_inflammation | 2.50572543 |
| 17 | MP0002148_abnormal_hypersensitivity_rea | 2.46216860 |
| 18 | MP0005025_abnormal_response_to | 2.40811292 |
| 19 | MP0000716_abnormal_immune_system | 2.38373942 |
| 20 | MP0004381_abnormal_hair_follicle | 2.37146751 |
| 21 | MP0009333_abnormal_splenocyte_physiolog | 2.32235233 |
| 22 | MP0002405_respiratory_system_inflammati | 2.31618132 |
| 23 | MP0003436_decreased_susceptibility_to | 2.23690947 |
| 24 | MP0003303_peritoneal_inflammation | 2.21224661 |
| 25 | MP0003724_increased_susceptibility_to | 2.19778537 |
| 26 | MP0002166_altered_tumor_susceptibility | 2.18246756 |
| 27 | MP0000703_abnormal_thymus_morphology | 2.12138658 |
| 28 | MP0000689_abnormal_spleen_morphology | 2.06985300 |
| 29 | MP0002722_abnormal_immune_system | 2.00491092 |
| 30 | MP0002006_tumorigenesis | 1.98756348 |
| 31 | MP0000569_abnormal_digit_pigmentation | 1.92482683 |
| 32 | MP0002933_joint_inflammation | 1.91306281 |
| 33 | MP0002419_abnormal_innate_immunity | 1.90599995 |
| 34 | MP0003866_abnormal_defecation | 1.86293321 |
| 35 | MP0002429_abnormal_blood_cell | 1.83298875 |
| 36 | MP0010155_abnormal_intestine_physiology | 1.78930596 |
| 37 | MP0004510_myositis | 1.71027065 |
| 38 | MP0002396_abnormal_hematopoietic_system | 1.69472980 |
| 39 | MP0005310_abnormal_salivary_gland | 1.62900382 |
| 40 | MP0001845_abnormal_inflammatory_respons | 1.50061573 |
| 41 | MP0004947_skin_inflammation | 1.49520984 |
| 42 | MP0003300_gastrointestinal_ulcer | 1.49305575 |
| 43 | MP0001853_heart_inflammation | 1.48987612 |
| 44 | MP0003787_abnormal_imprinting | 1.47142173 |
| 45 | MP0003172_abnormal_lysosome_physiology | 1.47034386 |
| 46 | MP0000465_gastrointestinal_hemorrhage | 1.39287280 |
| 47 | MP0002277_abnormal_respiratory_mucosa | 1.33639647 |
| 48 | MP0002132_abnormal_respiratory_system | 1.29861640 |
| 49 | MP0005464_abnormal_platelet_physiology | 1.25610636 |
| 50 | MP0003828_pulmonary_edema | 1.24604263 |
| 51 | MP0008057_abnormal_DNA_replication | 1.15119056 |
| 52 | MP0002009_preneoplasia | 1.12132245 |
| 53 | MP0004742_abnormal_vestibular_system | 1.09172133 |
| 54 | MP0001986_abnormal_taste_sensitivity | 1.08591880 |
| 55 | MP0005075_abnormal_melanosome_morpholog | 1.05679321 |
| 56 | MP0002138_abnormal_hepatobiliary_system | 1.05414752 |
| 57 | MP0003221_abnormal_cardiomyocyte_apopto | 1.05058638 |
| 58 | MP0008877_abnormal_DNA_methylation | 1.03979256 |
| 59 | MP0003448_altered_tumor_morphology | 1.03691962 |
| 60 | MP0001851_eye_inflammation | 1.03150035 |
| 61 | MP0004883_abnormal_blood_vessel | 1.02077467 |
| 62 | MP0005451_abnormal_body_composition | 0.99581887 |
| 63 | MP0005174_abnormal_tail_pigmentation | 0.97244544 |
| 64 | MP0002102_abnormal_ear_morphology | 0.96007150 |
| 65 | MP0003656_abnormal_erythrocyte_physiolo | 0.95372414 |
| 66 | MP0005409_darkened_coat_color | 0.91021429 |
| 67 | MP0009278_abnormal_bone_marrow | 0.89854876 |
| 68 | MP0000858_altered_metastatic_potential | 0.89844119 |
| 69 | MP0000490_abnormal_crypts_of | 0.89355537 |
| 70 | MP0004808_abnormal_hematopoietic_stem | 0.89245741 |
| 71 | MP0005645_abnormal_hypothalamus_physiol | 0.88797328 |
| 72 | MP0003136_yellow_coat_color | 0.88290583 |
| 73 | MP0008469_abnormal_protein_level | 0.87589694 |
| 74 | MP0001533_abnormal_skeleton_physiology | 0.87333572 |
| 75 | MP0005397_hematopoietic_system_phenotyp | 0.86609601 |
| 76 | MP0001545_abnormal_hematopoietic_system | 0.86609601 |
| 77 | MP0000015_abnormal_ear_pigmentation | 0.85899426 |
| 78 | MP0006292_abnormal_olfactory_placode | 0.84941468 |
| 79 | MP0002998_abnormal_bone_remodeling | 0.84249478 |
| 80 | MP0000920_abnormal_myelination | 0.79249542 |
| 81 | MP0003880_abnormal_central_pattern | 0.77608805 |
| 82 | MP0004130_abnormal_muscle_cell | 0.77272984 |
| 83 | MP0003045_fibrosis | 0.76243387 |
| 84 | MP0001348_abnormal_lacrimal_gland | 0.74574699 |
| 85 | MP0005423_abnormal_somatic_nervous | 0.72941915 |
| 86 | MP0001663_abnormal_digestive_system | 0.70291294 |
| 87 | MP0003091_abnormal_cell_migration | 0.68396831 |
| 88 | MP0000383_abnormal_hair_follicle | 0.67322380 |
| 89 | MP0009764_decreased_sensitivity_to | 0.67111118 |
| 90 | MP0001188_hyperpigmentation | 0.64285747 |
| 91 | MP0001501_abnormal_sleep_pattern | 0.63423282 |
| 92 | MP0008569_lethality_at_weaning | 0.62741993 |
| 93 | MP0000604_amyloidosis | 0.62533897 |
| 94 | MP0000249_abnormal_blood_vessel | 0.60611391 |
| 95 | MP0003252_abnormal_bile_duct | 0.59173939 |
| 96 | MP0009765_abnormal_xenobiotic_induced | 0.59106205 |
| 97 | MP0002735_abnormal_chemical_nociception | 0.56706965 |
| 98 | MP0002095_abnormal_skin_pigmentation | 0.56230954 |
| 99 | MP0002019_abnormal_tumor_incidence | 0.55925753 |
| 100 | MP0005164_abnormal_response_to | 0.52390158 |
| 101 | MP0002163_abnormal_gland_morphology | 0.51713556 |
| 102 | MP0003183_abnormal_peptide_metabolism | 0.49821372 |
| 103 | MP0009115_abnormal_fat_cell | 0.48160808 |
| 104 | MP0003690_abnormal_glial_cell | 0.46880182 |
| 105 | MP0003191_abnormal_cellular_cholesterol | 0.46850612 |
| 106 | MP0005166_decreased_susceptibility_to | 0.46736755 |
| 107 | MP0002693_abnormal_pancreas_physiology | 0.46690233 |
| 108 | MP0003795_abnormal_bone_structure | 0.45885249 |
| 109 | MP0004185_abnormal_adipocyte_glucose | 0.45310411 |
| 110 | MP0008260_abnormal_autophagy | 0.44587695 |
| 111 | MP0009763_increased_sensitivity_to | 0.44567936 |
| 112 | MP0005621_abnormal_cell_physiology | 0.43919719 |
| 113 | MP0008961_abnormal_basal_metabolism | 0.43648959 |
| 114 | MP0005390_skeleton_phenotype | 0.42816363 |
| 115 | MP0002822_catalepsy | 0.42655344 |
| 116 | MP0001191_abnormal_skin_condition | 0.42514498 |
| 117 | MP0000609_abnormal_liver_physiology | 0.42427058 |
| 118 | MP0005379_endocrine/exocrine_gland_phen | 0.42376732 |
| 119 | MP0008874_decreased_physiological_sensi | 0.42129616 |
| 120 | MP0001905_abnormal_dopamine_level | 0.41414885 |
| 121 | MP0005646_abnormal_pituitary_gland | 0.41177620 |
| 122 | MP0001486_abnormal_startle_reflex | 0.40679115 |
| 123 | MP0003938_abnormal_ear_development | 0.40674483 |
| 124 | MP0001216_abnormal_epidermal_layer | 0.39376122 |
| 125 | MP0001919_abnormal_reproductive_system | 0.37860967 |
| 126 | MP0005381_digestive/alimentary_phenotyp | 0.37464703 |
| 127 | MP0002136_abnormal_kidney_physiology | 0.36641976 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 5.84648181 |
| 2 | Abnormality of T cell number (HP:0011839) | 5.63696377 |
| 3 | Stomatitis (HP:0010280) | 4.85460136 |
| 4 | Panhypogammaglobulinemia (HP:0003139) | 4.76955939 |
| 5 | Agammaglobulinemia (HP:0004432) | 4.74856225 |
| 6 | Recurrent bronchitis (HP:0002837) | 4.61031973 |
| 7 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.40522568 |
| 8 | IgM deficiency (HP:0002850) | 4.37602010 |
| 9 | Abnormality of T cells (HP:0002843) | 4.24544332 |
| 10 | Chronic otitis media (HP:0000389) | 4.24167698 |
| 11 | Recurrent sinusitis (HP:0011108) | 4.18108510 |
| 12 | Recurrent cutaneous fungal infections (HP:0011370) | 4.17745069 |
| 13 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.17745069 |
| 14 | Recurrent fungal infections (HP:0002841) | 4.06513709 |
| 15 | Recurrent viral infections (HP:0004429) | 4.03955855 |
| 16 | Severe combined immunodeficiency (HP:0004430) | 3.86698507 |
| 17 | Meningitis (HP:0001287) | 3.85526604 |
| 18 | IgG deficiency (HP:0004315) | 3.82861307 |
| 19 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.72192648 |
| 20 | Eczematoid dermatitis (HP:0000976) | 3.68561740 |
| 21 | Chronic diarrhea (HP:0002028) | 3.66197410 |
| 22 | Lymphopenia (HP:0001888) | 3.63404577 |
| 23 | Vasculitis (HP:0002633) | 3.60059620 |
| 24 | Gastrointestinal stroma tumor (HP:0100723) | 3.54811177 |
| 25 | Inflammation of the large intestine (HP:0002037) | 3.51566746 |
| 26 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.43526181 |
| 27 | Chronic sinusitis (HP:0011109) | 3.41617535 |
| 28 | Retrobulbar optic neuritis (HP:0100654) | 3.40956701 |
| 29 | Optic neuritis (HP:0100653) | 3.40956701 |
| 30 | Combined immunodeficiency (HP:0005387) | 3.40631866 |
| 31 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.39795891 |
| 32 | Abnormality of B cell number (HP:0010975) | 3.27830972 |
| 33 | B lymphocytopenia (HP:0010976) | 3.27830972 |
| 34 | Encephalitis (HP:0002383) | 3.22178763 |
| 35 | Obstructive lung disease (HP:0006536) | 3.20463169 |
| 36 | Chronic obstructive pulmonary disease (HP:0006510) | 3.20463169 |
| 37 | Gastrointestinal inflammation (HP:0004386) | 3.20165027 |
| 38 | Myositis (HP:0100614) | 3.18283184 |
| 39 | Mediastinal lymphadenopathy (HP:0100721) | 3.15280184 |
| 40 | IgA deficiency (HP:0002720) | 3.13013304 |
| 41 | Nasal polyposis (HP:0100582) | 3.08949852 |
| 42 | Pulmonary infiltrates (HP:0002113) | 3.08160527 |
| 43 | Increased IgM level (HP:0003496) | 3.06853614 |
| 44 | Abnormality of macrophages (HP:0004311) | 3.03329859 |
| 45 | Hypoplasia of the thymus (HP:0000778) | 2.95047229 |
| 46 | Abnormality of T cell physiology (HP:0011840) | 2.91951304 |
| 47 | Abnormality of the fingertips (HP:0001211) | 2.90985847 |
| 48 | Recurrent abscess formation (HP:0002722) | 2.81679814 |
| 49 | Autoimmune hemolytic anemia (HP:0001890) | 2.75502660 |
| 50 | Abnormality of eosinophils (HP:0001879) | 2.74440276 |
| 51 | Colitis (HP:0002583) | 2.69562487 |
| 52 | Pustule (HP:0200039) | 2.67232137 |
| 53 | Slow saccadic eye movements (HP:0000514) | 2.67016445 |
| 54 | Thyroiditis (HP:0100646) | 2.65841914 |
| 55 | Eosinophilia (HP:0001880) | 2.63476533 |
| 56 | Bronchitis (HP:0012387) | 2.60917073 |
| 57 | Gingivitis (HP:0000230) | 2.59528054 |
| 58 | Lymphoma (HP:0002665) | 2.57669601 |
| 59 | Hemoptysis (HP:0002105) | 2.56167382 |
| 60 | Recurrent skin infections (HP:0001581) | 2.53243727 |
| 61 | Papilledema (HP:0001085) | 2.50308298 |
| 62 | Orchitis (HP:0100796) | 2.48768635 |
| 63 | Recurrent otitis media (HP:0000403) | 2.45733955 |
| 64 | Fatigue (HP:0012378) | 2.40379987 |
| 65 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.38520104 |
| 66 | Emphysema (HP:0002097) | 2.37608769 |
| 67 | Leukocytosis (HP:0001974) | 2.37518108 |
| 68 | Spontaneous hematomas (HP:0007420) | 2.36563179 |
| 69 | Joint swelling (HP:0001386) | 2.36146912 |
| 70 | Granulocytopenia (HP:0001913) | 2.29193919 |
| 71 | Abnormality of the prostate (HP:0008775) | 2.28862637 |
| 72 | Abnormal hair whorl (HP:0010721) | 2.28025164 |
| 73 | Abnormality of the nasal mucosa (HP:0000433) | 2.26241792 |
| 74 | Keratoconjunctivitis sicca (HP:0001097) | 2.25685575 |
| 75 | Viral hepatitis (HP:0006562) | 2.25674704 |
| 76 | Bronchiectasis (HP:0002110) | 2.24186451 |
| 77 | Acute hepatic failure (HP:0006554) | 2.23557481 |
| 78 | Parakeratosis (HP:0001036) | 2.22181033 |
| 79 | Papilloma (HP:0012740) | 2.21749101 |
| 80 | Verrucae (HP:0200043) | 2.21749101 |
| 81 | Cheilitis (HP:0100825) | 2.20802222 |
| 82 | Subacute progressive viral hepatitis (HP:0006572) | 2.20448725 |
| 83 | Urticaria (HP:0001025) | 2.17200483 |
| 84 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.15687026 |
| 85 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.14869054 |
| 86 | Stomach cancer (HP:0012126) | 2.10407190 |
| 87 | Anorexia (HP:0002039) | 2.10351937 |
| 88 | Aplasia cutis congenita (HP:0001057) | 2.10242145 |
| 89 | Basal cell carcinoma (HP:0002671) | 2.08743457 |
| 90 | Keratoconjunctivitis (HP:0001096) | 2.08618218 |
| 91 | Chest pain (HP:0100749) | 2.07190152 |
| 92 | Osteomyelitis (HP:0002754) | 2.06724222 |
| 93 | Prolonged bleeding time (HP:0003010) | 2.06667582 |
| 94 | Restrictive lung disease (HP:0002091) | 2.05311172 |
| 95 | Increased IgE level (HP:0003212) | 2.04733544 |
| 96 | Gastrointestinal infarctions (HP:0005244) | 2.04262686 |
| 97 | Alveolar cell carcinoma (HP:0006519) | 2.03693743 |
| 98 | Amaurosis fugax (HP:0100576) | 2.03645603 |
| 99 | Hypergammaglobulinemia (HP:0010702) | 2.02114929 |
| 100 | Cellulitis (HP:0100658) | 2.01580236 |
| 101 | Recurrent pneumonia (HP:0006532) | 2.00509213 |
| 102 | Recurrent bacterial skin infections (HP:0005406) | 1.99936690 |
| 103 | Microcytic anemia (HP:0001935) | 1.98006625 |
| 104 | Abnormality of the pleura (HP:0002103) | 1.96471876 |
| 105 | Arterial thrombosis (HP:0004420) | 1.92612499 |
| 106 | Gangrene (HP:0100758) | 1.91750010 |
| 107 | Pulmonary embolism (HP:0002204) | 1.87480615 |
| 108 | Diplopia (HP:0000651) | 1.86107127 |
| 109 | Abnormality of binocular vision (HP:0011514) | 1.86107127 |
| 110 | Hypochromic anemia (HP:0001931) | 1.86105482 |
| 111 | Abnormality of DNA repair (HP:0003254) | 1.86010216 |
| 112 | Xerostomia (HP:0000217) | 1.85578126 |
| 113 | Leukopenia (HP:0001882) | 1.84201474 |
| 114 | Gingival bleeding (HP:0000225) | 1.81008921 |
| 115 | Epistaxis (HP:0000421) | 1.79828993 |
| 116 | Recurrent lower respiratory tract infections (HP:0002783) | 1.79559459 |
| 117 | Ureteral stenosis (HP:0000071) | 1.76472834 |
| 118 | Lip pit (HP:0100267) | 1.76203659 |
| 119 | Autoimmune thrombocytopenia (HP:0001973) | 1.74126093 |
| 120 | Arthralgia (HP:0002829) | 1.73806977 |
| 121 | Thrombocytosis (HP:0001894) | 1.73806215 |
| 122 | Glomerulopathy (HP:0100820) | 1.72486026 |
| 123 | Sepsis (HP:0100806) | 1.72118827 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.83193648 |
| 2 | MAP4K1 | 5.29111412 |
| 3 | MAP3K14 | 3.15243142 |
| 4 | JAK3 | 2.98649968 |
| 5 | BLK | 2.80864810 |
| 6 | ITK | 2.67419901 |
| 7 | TAOK3 | 2.39699363 |
| 8 | IKBKE | 2.21101845 |
| 9 | MST4 | 2.17034755 |
| 10 | MAP3K13 | 2.15139509 |
| 11 | ZAP70 | 2.08561051 |
| 12 | STK10 | 2.01549320 |
| 13 | TYK2 | 1.93027855 |
| 14 | GRK6 | 1.88681041 |
| 15 | LCK | 1.85360594 |
| 16 | JAK1 | 1.82714574 |
| 17 | NLK | 1.82028146 |
| 18 | TEC | 1.81666513 |
| 19 | SYK | 1.73086102 |
| 20 | IRAK4 | 1.70968311 |
| 21 | IKBKB | 1.64476502 |
| 22 | SIK2 | 1.62668425 |
| 23 | TNK2 | 1.60309364 |
| 24 | FGFR4 | 1.59386656 |
| 25 | PRKCQ | 1.55440714 |
| 26 | BTK | 1.52313937 |
| 27 | CAMKK2 | 1.51792905 |
| 28 | PRPF4B | 1.50733269 |
| 29 | CSK | 1.47982537 |
| 30 | PASK | 1.46593246 |
| 31 | MAP3K10 | 1.39967425 |
| 32 | HCK | 1.37087337 |
| 33 | CASK | 1.36654960 |
| 34 | SIK3 | 1.36088925 |
| 35 | FGFR3 | 1.31433539 |
| 36 | RIPK4 | 1.30272847 |
| 37 | FES | 1.28623388 |
| 38 | MAP2K3 | 1.26213010 |
| 39 | CLK1 | 1.25840497 |
| 40 | CAMKK1 | 1.18927527 |
| 41 | LYN | 1.13071285 |
| 42 | KIT | 1.08510848 |
| 43 | NUAK1 | 1.07047769 |
| 44 | TBK1 | 1.04081509 |
| 45 | CHUK | 1.03788734 |
| 46 | MKNK2 | 1.02982687 |
| 47 | MARK3 | 1.02046853 |
| 48 | CDK6 | 0.96841059 |
| 49 | IRAK3 | 0.96447688 |
| 50 | PIK3CG | 0.96435852 |
| 51 | PRKCH | 0.93940094 |
| 52 | PKN1 | 0.92291959 |
| 53 | IRAK1 | 0.91327383 |
| 54 | CSF1R | 0.89790385 |
| 55 | CDK4 | 0.86762317 |
| 56 | MAPK7 | 0.82314907 |
| 57 | ADRBK2 | 0.79218714 |
| 58 | MAP3K1 | 0.78724368 |
| 59 | BMPR2 | 0.78715729 |
| 60 | LRRK2 | 0.78314085 |
| 61 | PRKD2 | 0.78174925 |
| 62 | MAP3K7 | 0.75652235 |
| 63 | EPHB1 | 0.75487275 |
| 64 | BRD4 | 0.75018258 |
| 65 | TNIK | 0.74801678 |
| 66 | MAPK11 | 0.74257114 |
| 67 | FGR | 0.73905523 |
| 68 | GRK1 | 0.73726770 |
| 69 | GRK7 | 0.73210528 |
| 70 | NTRK2 | 0.73083750 |
| 71 | TYRO3 | 0.72106391 |
| 72 | PIM1 | 0.72069693 |
| 73 | YES1 | 0.68811857 |
| 74 | STK24 | 0.66200975 |
| 75 | MARK2 | 0.65272629 |
| 76 | MATK | 0.59739293 |
| 77 | IRAK2 | 0.58100730 |
| 78 | EPHA3 | 0.54154593 |
| 79 | INSR | 0.53388778 |
| 80 | JAK2 | 0.51277898 |
| 81 | MAP3K2 | 0.50748020 |
| 82 | MAPK12 | 0.50661373 |
| 83 | HIPK2 | 0.50658585 |
| 84 | FYN | 0.48360087 |
| 85 | NME2 | 0.48232250 |
| 86 | SMG1 | 0.47646320 |
| 87 | TGFBR2 | 0.47179346 |
| 88 | EEF2K | 0.46914329 |
| 89 | KSR2 | 0.46779211 |
| 90 | TRPM7 | 0.45527255 |
| 91 | NEK6 | 0.44717064 |
| 92 | RET | 0.43971826 |
| 93 | CDK3 | 0.43384773 |
| 94 | CDK12 | 0.43040771 |
| 95 | EGFR | 0.42970308 |
| 96 | ROCK2 | 0.41765694 |
| 97 | MKNK1 | 0.41447762 |
| 98 | DYRK1B | 0.38921652 |
| 99 | ABL1 | 0.38183798 |
| 100 | CDK9 | 0.37747432 |
| 101 | MAP3K3 | 0.37516882 |
| 102 | PDK1 | 0.37159751 |
| 103 | MAP3K5 | 0.37089367 |
| 104 | RPS6KA5 | 0.36576890 |
| 105 | IGF1R | 0.34961037 |
| 106 | TAOK2 | 0.34788368 |
| 107 | ERN1 | 0.34392645 |
| 108 | MAP3K11 | 0.33998798 |
| 109 | WNK1 | 0.32977313 |
| 110 | EIF2AK2 | 0.32720081 |
| 111 | RPS6KL1 | 0.31903336 |
| 112 | RPS6KC1 | 0.31903336 |
| 113 | CAMK1G | 0.31219127 |
| 114 | SGK2 | 0.28910298 |
| 115 | RPS6KA6 | 0.28535903 |
| 116 | ALK | 0.28490212 |
| 117 | CAMK4 | 0.28325702 |
| 118 | PDGFRB | 0.27423205 |
| 119 | STK4 | 0.27314674 |
| 120 | PTK2B | 0.27313299 |
| 121 | DMPK | 0.27224573 |
| 122 | MAPK4 | 0.27036335 |
| 123 | MAP3K12 | 0.26447668 |
| 124 | MAPK3 | 0.25721046 |
| 125 | FGFR2 | 0.25286005 |
| 126 | SGK1 | 0.25232198 |
| 127 | RAF1 | 0.24058479 |
| 128 | MAPKAPK2 | 0.23988217 |
| 129 | MELK | 0.23312839 |
| 130 | TAOK1 | 0.22166687 |
| 131 | CSNK1A1L | 0.21063331 |
| 132 | DYRK1A | 0.20035478 |
| 133 | SGK3 | 0.18744753 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.00310084 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.38676612 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.24525079 |
| 4 | Allograft rejection_Homo sapiens_hsa05330 | 3.16742295 |
| 5 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.06836121 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.79987391 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.79499704 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.65997718 |
| 9 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.54437441 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.46549310 |
| 11 | Measles_Homo sapiens_hsa05162 | 2.43730681 |
| 12 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.37864275 |
| 13 | Leishmaniasis_Homo sapiens_hsa05140 | 1.80480005 |
| 14 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.73357097 |
| 15 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.70176584 |
| 16 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.68355782 |
| 17 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.64887112 |
| 18 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.59370433 |
| 19 | Asthma_Homo sapiens_hsa05310 | 1.58226960 |
| 20 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.56018719 |
| 21 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.49786658 |
| 22 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.47352159 |
| 23 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.42205210 |
| 24 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.41904310 |
| 25 | Viral myocarditis_Homo sapiens_hsa05416 | 1.29490850 |
| 26 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.22720840 |
| 27 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.17096520 |
| 28 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.14160551 |
| 29 | Malaria_Homo sapiens_hsa05144 | 1.07006677 |
| 30 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.05135413 |
| 31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.04643258 |
| 32 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.03410609 |
| 33 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.00830964 |
| 34 | Hepatitis B_Homo sapiens_hsa05161 | 0.98537844 |
| 35 | Influenza A_Homo sapiens_hsa05164 | 0.94912858 |
| 36 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.90304446 |
| 37 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.90286319 |
| 38 | Ribosome_Homo sapiens_hsa03010 | 0.90263977 |
| 39 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.90199221 |
| 40 | Endometrial cancer_Homo sapiens_hsa05213 | 0.88930275 |
| 41 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.87748283 |
| 42 | Tuberculosis_Homo sapiens_hsa05152 | 0.87565230 |
| 43 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.84116855 |
| 44 | Shigellosis_Homo sapiens_hsa05131 | 0.81679701 |
| 45 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.81424271 |
| 46 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.76437202 |
| 47 | HTLV-I infection_Homo sapiens_hsa05166 | 0.75944919 |
| 48 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.75097970 |
| 49 | Platelet activation_Homo sapiens_hsa04611 | 0.75036000 |
| 50 | Hepatitis C_Homo sapiens_hsa05160 | 0.71832315 |
| 51 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.71742794 |
| 52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.70602983 |
| 53 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.70032970 |
| 54 | Thyroid cancer_Homo sapiens_hsa05216 | 0.68978676 |
| 55 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.68739397 |
| 56 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.67175931 |
| 57 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66405778 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.65707134 |
| 59 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.63769758 |
| 60 | Apoptosis_Homo sapiens_hsa04210 | 0.62783452 |
| 61 | Glioma_Homo sapiens_hsa05214 | 0.62569255 |
| 62 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.60896612 |
| 63 | Pertussis_Homo sapiens_hsa05133 | 0.60521302 |
| 64 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.60130740 |
| 65 | Salmonella infection_Homo sapiens_hsa05132 | 0.58171366 |
| 66 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.57013309 |
| 67 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.56661566 |
| 68 | Long-term potentiation_Homo sapiens_hsa04720 | 0.55591702 |
| 69 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.54704950 |
| 70 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.51049855 |
| 71 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.49924383 |
| 72 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.49847374 |
| 73 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.49573354 |
| 74 | Insulin resistance_Homo sapiens_hsa04931 | 0.49036602 |
| 75 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.47768118 |
| 76 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47490424 |
| 77 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.46978039 |
| 78 | Morphine addiction_Homo sapiens_hsa05032 | 0.46820173 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.46295933 |
| 80 | Legionellosis_Homo sapiens_hsa05134 | 0.46203947 |
| 81 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.45746734 |
| 82 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44987969 |
| 83 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.44311117 |
| 84 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.43746878 |
| 85 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.43746618 |
| 86 | Endocytosis_Homo sapiens_hsa04144 | 0.41816118 |
| 87 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.39900137 |
| 88 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.39764350 |
| 89 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.39509746 |
| 90 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.39269322 |
| 91 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.37898080 |
| 92 | Nicotine addiction_Homo sapiens_hsa05033 | 0.37537196 |
| 93 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.37419401 |
| 94 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.36892695 |
| 95 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36351759 |
| 96 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.36201727 |
| 97 | Prostate cancer_Homo sapiens_hsa05215 | 0.36169817 |
| 98 | Colorectal cancer_Homo sapiens_hsa05210 | 0.35993193 |
| 99 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.35649873 |
| 100 | Spliceosome_Homo sapiens_hsa03040 | 0.34618832 |
| 101 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.34090773 |
| 102 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.34020140 |
| 103 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.33608144 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.32926240 |
| 105 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.30709719 |
| 106 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.30314933 |
| 107 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.30086066 |
| 108 | Phagosome_Homo sapiens_hsa04145 | 0.29993378 |
| 109 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.29812550 |
| 110 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.29605657 |
| 111 | Renin secretion_Homo sapiens_hsa04924 | 0.29026853 |
| 112 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.28503180 |
| 113 | Taste transduction_Homo sapiens_hsa04742 | 0.28388297 |
| 114 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.27865319 |
| 115 | RNA degradation_Homo sapiens_hsa03018 | 0.27338121 |
| 116 | Axon guidance_Homo sapiens_hsa04360 | 0.27309592 |
| 117 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.26231414 |
| 118 | Long-term depression_Homo sapiens_hsa04730 | 0.24843138 |
| 119 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.24706034 |
| 120 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.23970059 |
| 121 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.23940606 |
| 122 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.23599218 |
| 123 | Salivary secretion_Homo sapiens_hsa04970 | 0.23306936 |

