GPR180

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.08815016
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.08815016
3L-phenylalanine catabolic process (GO:0006559)4.95764967
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.95764967
5mitotic sister chromatid cohesion (GO:0007064)4.53486910
6kinetochore organization (GO:0051383)4.43553868
7exocrine pancreas development (GO:0031017)4.40912559
8ribosome assembly (GO:0042255)4.30710079
9nuclear pore complex assembly (GO:0051292)4.23577951
10metaphase plate congression (GO:0051310)4.21852223
11nuclear pore organization (GO:0006999)4.11081107
12mitotic metaphase plate congression (GO:0007080)4.07753728
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.06839641
14aromatic amino acid family catabolic process (GO:0009074)4.03409720
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.91146763
16DNA unwinding involved in DNA replication (GO:0006268)3.91057099
17protein retention in ER lumen (GO:0006621)3.90616687
18CENP-A containing nucleosome assembly (GO:0034080)3.86791352
19DNA ligation (GO:0006266)3.77219108
20peptidyl-proline hydroxylation (GO:0019511)3.77124606
21chromatin remodeling at centromere (GO:0031055)3.75794767
22non-recombinational repair (GO:0000726)3.71315267
23double-strand break repair via nonhomologous end joining (GO:0006303)3.71315267
24COPI coating of Golgi vesicle (GO:0048205)3.70450150
25Golgi transport vesicle coating (GO:0048200)3.70450150
26lysine metabolic process (GO:0006553)3.68768347
27lysine catabolic process (GO:0006554)3.68768347
28sister chromatid segregation (GO:0000819)3.68344243
29establishment of chromosome localization (GO:0051303)3.68094590
30fat-soluble vitamin biosynthetic process (GO:0042362)3.67843620
31kinetochore assembly (GO:0051382)3.58087709
32COPII vesicle coating (GO:0048208)3.53424907
33peptidyl-glutamic acid carboxylation (GO:0017187)3.52314894
34protein carboxylation (GO:0018214)3.52314894
35spindle checkpoint (GO:0031577)3.52121957
36regulation of glucokinase activity (GO:0033131)3.49736958
37regulation of hexokinase activity (GO:1903299)3.49736958
38coenzyme catabolic process (GO:0009109)3.48747660
39regulation of centriole replication (GO:0046599)3.45693987
40protein localization to kinetochore (GO:0034501)3.45030719
41nucleotide transmembrane transport (GO:1901679)3.42145267
42cysteine metabolic process (GO:0006534)3.37387128
43tyrosine metabolic process (GO:0006570)3.37367744
44mitotic sister chromatid segregation (GO:0000070)3.37125912
45branched-chain amino acid catabolic process (GO:0009083)3.36036422
46mitotic spindle checkpoint (GO:0071174)3.33280997
47valine metabolic process (GO:0006573)3.32768590
48aspartate family amino acid catabolic process (GO:0009068)3.32316800
49sulfur amino acid catabolic process (GO:0000098)3.31361557
50intestinal cholesterol absorption (GO:0030299)3.31196538
51pore complex assembly (GO:0046931)3.30428864
52glyoxylate metabolic process (GO:0046487)3.26254815
53polyketide metabolic process (GO:0030638)3.25615238
54doxorubicin metabolic process (GO:0044598)3.25615238
55daunorubicin metabolic process (GO:0044597)3.25615238
56tryptophan catabolic process (GO:0006569)3.25144290
57indole-containing compound catabolic process (GO:0042436)3.25144290
58indolalkylamine catabolic process (GO:0046218)3.25144290
59alpha-linolenic acid metabolic process (GO:0036109)3.24273486
60regulation of DNA endoreduplication (GO:0032875)3.23373289
61histone exchange (GO:0043486)3.23235893
62ether lipid metabolic process (GO:0046485)3.22683733
63extracellular negative regulation of signal transduction (GO:1900116)3.22378703
64extracellular regulation of signal transduction (GO:1900115)3.22378703
65aromatic amino acid family metabolic process (GO:0009072)3.17577157
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17017806
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17017806
68proteasome assembly (GO:0043248)3.14734784
69tryptophan metabolic process (GO:0006568)3.12258736
70regulation of transforming growth factor beta2 production (GO:0032909)3.12253312
71protein localization to chromosome, centromeric region (GO:0071459)3.12183652
72protein hydroxylation (GO:0018126)3.10236911
73triglyceride homeostasis (GO:0070328)3.09659342
74acylglycerol homeostasis (GO:0055090)3.09659342
75regulation of mitotic sister chromatid separation (GO:0010965)3.07978791
76regulation of mitotic sister chromatid segregation (GO:0033047)3.07978791
77regulation of sister chromatid segregation (GO:0033045)3.07978791
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.07543567
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07543567
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07543567
81bile acid biosynthetic process (GO:0006699)3.05289054
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05100828
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05100828
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.05100828
85negative regulation of sister chromatid segregation (GO:0033046)3.05100828
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05100828
87cullin deneddylation (GO:0010388)3.04513565
88negative regulation of chromosome segregation (GO:0051985)3.04171335
89mitotic spindle assembly checkpoint (GO:0007094)3.01473246
90spindle assembly checkpoint (GO:0071173)3.00330427
91branched-chain amino acid metabolic process (GO:0009081)3.00265490
92resolution of meiotic recombination intermediates (GO:0000712)3.00023312
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.99663140
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.99012441
95negative regulation of fibrinolysis (GO:0051918)2.98578823
96regulation of protein activation cascade (GO:2000257)2.98312674
97regulation of centrosome cycle (GO:0046605)2.98265236
98bile acid and bile salt transport (GO:0015721)2.97860006
99mitotic chromosome condensation (GO:0007076)2.97589349
100purine nucleobase biosynthetic process (GO:0009113)2.97555216
101response to X-ray (GO:0010165)2.95360806
1024-hydroxyproline metabolic process (GO:0019471)2.93200850
103UDP-N-acetylglucosamine metabolic process (GO:0006047)2.92698675
104alpha-amino acid catabolic process (GO:1901606)2.92637108
105bile acid metabolic process (GO:0008206)2.92238035
106mitotic nuclear envelope disassembly (GO:0007077)2.91983054
107regulation of chromosome segregation (GO:0051983)2.90895562
108establishment of integrated proviral latency (GO:0075713)2.90885317
109homocysteine metabolic process (GO:0050667)2.90423977
110kynurenine metabolic process (GO:0070189)2.90005761
111cellular ketone body metabolic process (GO:0046950)2.89644021
112chondrocyte development (GO:0002063)2.89504068
113cellular glucuronidation (GO:0052695)2.89139052
114regulation of fibrinolysis (GO:0051917)2.88846430
115regulation of mitotic spindle organization (GO:0060236)2.86099984
116negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.86084687
117positive regulation of protein autophosphorylation (GO:0031954)2.85406301
118negative regulation of fatty acid transport (GO:2000192)2.83889040
119positive regulation of chromosome segregation (GO:0051984)2.82564890
120attachment of spindle microtubules to kinetochore (GO:0008608)2.81373763
121ventricular cardiac muscle cell development (GO:0055015)2.81276667
122regulation of centrosome duplication (GO:0010824)2.79150102
123regulation of complement activation (GO:0030449)2.79119589
124short-chain fatty acid metabolic process (GO:0046459)2.76807000
125cellular amino acid catabolic process (GO:0009063)2.76433668
126DNA strand elongation involved in DNA replication (GO:0006271)2.76377972
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75252218
128amino-acid betaine metabolic process (GO:0006577)2.74951818
129high-density lipoprotein particle remodeling (GO:0034375)2.72065037
130opsonization (GO:0008228)2.72057732
131fatty acid beta-oxidation (GO:0006635)2.71659338
132protein prenylation (GO:0018342)2.70968510
133prenylation (GO:0097354)2.70968510
134imidazole-containing compound metabolic process (GO:0052803)2.70638014
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.70188487
136protein K6-linked ubiquitination (GO:0085020)2.68922887
137dopamine biosynthetic process (GO:0042416)2.68619821
138urea metabolic process (GO:0019627)2.68056463
139urea cycle (GO:0000050)2.68056463
140DNA replication-independent nucleosome organization (GO:0034724)2.67734365
141DNA replication-independent nucleosome assembly (GO:0006336)2.67734365
142mitotic recombination (GO:0006312)2.67042637
143meiotic chromosome segregation (GO:0045132)2.65433739
144protein deneddylation (GO:0000338)2.65354691
145fatty acid catabolic process (GO:0009062)2.64939776
146negative regulation of lipase activity (GO:0060192)2.64400785
147drinking behavior (GO:0042756)2.63341043
148DNA strand elongation (GO:0022616)2.62363096
149vitamin biosynthetic process (GO:0009110)2.61651961
150DNA double-strand break processing (GO:0000729)2.61388429
151indolalkylamine metabolic process (GO:0006586)2.60481675
152nuclear envelope disassembly (GO:0051081)2.60410942
153membrane disassembly (GO:0030397)2.60410942
154regulation of spindle organization (GO:0090224)2.60303587
155fatty acid oxidation (GO:0019395)2.59182766
156sequestering of extracellular ligand from receptor (GO:0035581)2.58853246
157positive regulation of cardiac muscle hypertrophy (GO:0010613)2.58528969
158positive regulation of muscle hypertrophy (GO:0014742)2.58528969
159proline biosynthetic process (GO:0006561)2.57138552
160peroxisome fission (GO:0016559)2.56666437
161negative regulation of norepinephrine secretion (GO:0010700)2.56546499
162ketone body metabolic process (GO:1902224)2.56418673
163somatic recombination of immunoglobulin gene segments (GO:0016447)2.54320572
164nitrogen cycle metabolic process (GO:0071941)2.53534439
165retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53332074
166peroxisome organization (GO:0007031)2.53132155
167complement activation, alternative pathway (GO:0006957)2.51707128
168somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51051213
169isotype switching (GO:0045190)2.51051213
170somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51051213
171regulation of acyl-CoA biosynthetic process (GO:0050812)2.50517769
172negative regulation of protein activation cascade (GO:2000258)2.50482606
173cellular modified amino acid catabolic process (GO:0042219)2.49860586
174lipid oxidation (GO:0034440)2.49110800
175glucuronate metabolic process (GO:0019585)2.48325859
176uronic acid metabolic process (GO:0006063)2.48325859
177carboxylic acid catabolic process (GO:0046395)2.48033318
178organic acid catabolic process (GO:0016054)2.48033318
179folic acid-containing compound biosynthetic process (GO:0009396)2.47020580
180regulation of coenzyme metabolic process (GO:0051196)2.46793823
181regulation of cofactor metabolic process (GO:0051193)2.46793823
182DNA replication-dependent nucleosome assembly (GO:0006335)2.46433625
183DNA replication-dependent nucleosome organization (GO:0034723)2.46433625
184regulation of plasminogen activation (GO:0010755)2.45252560
185purine ribonucleotide transport (GO:0015868)2.44843131
186glycerol ether metabolic process (GO:0006662)2.44431448
187negative regulation of DNA repair (GO:0045738)2.44404857
188keratinocyte development (GO:0003334)2.43328452
189anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43064936
190fibroblast migration (GO:0010761)2.42712149
191monocarboxylic acid catabolic process (GO:0072329)2.42647847
192G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.42325067
193L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42319114
194somatic hypermutation of immunoglobulin genes (GO:0016446)2.42258043
195somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42258043
196regulation of sister chromatid cohesion (GO:0007063)2.41998484
197telomere maintenance via telomerase (GO:0007004)2.41709209
198rRNA methylation (GO:0031167)2.41694672
199neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.41658733
200positive regulation of fatty acid oxidation (GO:0046321)2.41266973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.61647542
2E2F7_22180533_ChIP-Seq_HELA_Human5.11290819
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.10103341
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.37947044
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29617859
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.24261493
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14815024
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02347382
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.96413352
10AR_21909140_ChIP-Seq_LNCAP_Human2.70233370
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.70004990
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63265404
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54705314
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.52847218
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49224820
16FUS_26573619_Chip-Seq_HEK293_Human2.46188362
17ELK1_19687146_ChIP-ChIP_HELA_Human2.44178277
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44149203
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34914905
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.34162369
21GBX2_23144817_ChIP-Seq_PC3_Human2.33339920
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30700790
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.29749839
24EWS_26573619_Chip-Seq_HEK293_Human2.25207534
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25196905
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11224369
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01571200
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.99460915
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.98091830
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88870011
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87643331
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86278618
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80069068
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.78459380
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.78380270
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69079841
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.69014309
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65644226
39IGF1R_20145208_ChIP-Seq_DFB_Human1.62917918
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62204647
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61529953
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58571757
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57347189
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.56693657
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53184501
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50694699
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.48080714
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46856333
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46762141
50BRD4_25478319_ChIP-Seq_HGPS_Human1.45775265
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.45204277
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43275933
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41853160
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41099976
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39433815
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37663371
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37180139
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36218286
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36218286
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35443680
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33071354
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33044034
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.32980501
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32219993
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30706754
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29418212
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29292690
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28917741
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27567504
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27289846
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.26826069
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26151700
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25063367
74P300_19829295_ChIP-Seq_ESCs_Human1.24257853
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23176582
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20677133
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20020461
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18753317
79MYC_18940864_ChIP-ChIP_HL60_Human1.18316160
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17362474
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16874963
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.16603028
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.16060706
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.15686261
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.15326926
86IRF1_19129219_ChIP-ChIP_H3396_Human1.14864635
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14488408
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13849915
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13824295
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.13731083
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.13720830
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.13112216
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12999349
94TP53_18474530_ChIP-ChIP_U2OS_Human1.12740241
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.12707142
96* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12673542
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11722040
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11442562
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10814093
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10318580
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10174313
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09872317
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09649290
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09570424
105VDR_23849224_ChIP-Seq_CD4+_Human1.09081074
106BCAT_22108803_ChIP-Seq_LS180_Human1.08792252
107P53_22387025_ChIP-Seq_ESCs_Mouse1.08146662
108DCP1A_22483619_ChIP-Seq_HELA_Human1.08000435
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05220792
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04942786
111JUN_21703547_ChIP-Seq_K562_Human1.04232059
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04134039
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.03766816
114P300_18555785_Chip-Seq_ESCs_Mouse1.03359138
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.02856312
116SMAD4_21799915_ChIP-Seq_A2780_Human1.02806529
117AR_21572438_ChIP-Seq_LNCaP_Human1.02229158
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01863525
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.01860504
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01777469
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.01678224
122WT1_19549856_ChIP-ChIP_CCG9911_Human1.00996410
123NANOG_16153702_ChIP-ChIP_HESCs_Human1.00818917
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.00429792
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99718776
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99718776
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99699554
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.99572973
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99403524
130* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98697973
131HTT_18923047_ChIP-ChIP_STHdh_Human0.98626776
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.97410251
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.96175904
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96156931
135CDX2_22108803_ChIP-Seq_LS180_Human0.95268647
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94416818
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.94221735
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93921042
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92994928
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92099137
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91909626
142RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91814691
143ER_23166858_ChIP-Seq_MCF-7_Human0.91666660
144* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91547456
145TAF15_26573619_Chip-Seq_HEK293_Human0.91500986
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91341898
147* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90770305
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90732518
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90336302
150CBP_21632823_ChIP-Seq_H3396_Human0.90000914
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89140739
152GATA1_22025678_ChIP-Seq_K562_Human0.89060248
153RXR_22108803_ChIP-Seq_LS180_Human0.88719932
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88466874
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87809712
156STAT3_23295773_ChIP-Seq_U87_Human0.87561957
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86877854
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.86633213
159NFYA_21822215_ChIP-Seq_K562_Human0.85868927
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85353772
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84646415
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84394271
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.84285793
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83259131
165* CJUN_26792858_Chip-Seq_BT549_Human0.83113962
166RUNX2_22187159_ChIP-Seq_PCA_Human0.81825586
167* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79883440
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.79832873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.74552194
2MP0005365_abnormal_bile_salt4.65307072
3MP0008057_abnormal_DNA_replication4.50796471
4MP0003122_maternal_imprinting3.98746594
5MP0005085_abnormal_gallbladder_physiolo3.85589482
6MP0010352_gastrointestinal_tract_polyps3.61426992
7MP0005360_urolithiasis3.54651763
8MP0010094_abnormal_chromosome_stability3.21554419
9MP0003806_abnormal_nucleotide_metabolis2.97753584
10MP0005220_abnormal_exocrine_pancreas2.87929187
11MP0003868_abnormal_feces_composition2.77480329
12MP0008438_abnormal_cutaneous_collagen2.74169739
13MP0008058_abnormal_DNA_repair2.70682399
14MP0008875_abnormal_xenobiotic_pharmacok2.62280019
15MP0009697_abnormal_copulation2.60589878
16MP0005171_absent_coat_pigmentation2.59196025
17MP0004957_abnormal_blastocyst_morpholog2.55353283
18MP0000372_irregular_coat_pigmentation2.52245408
19MP0005257_abnormal_intraocular_pressure2.45957208
20MP0005623_abnormal_meninges_morphology2.44469648
21MP0001666_abnormal_nutrient_absorption2.35105570
22MP0005503_abnormal_tendon_morphology2.32974774
23MP0005670_abnormal_white_adipose2.30035033
24MP0003111_abnormal_nucleus_morphology2.28963113
25MP0002877_abnormal_melanocyte_morpholog2.24727708
26MP0003077_abnormal_cell_cycle2.24409039
27MP0003941_abnormal_skin_development2.17422578
28MP0003252_abnormal_bile_duct2.16001334
29MP0005083_abnormal_biliary_tract2.02627204
30MP0010329_abnormal_lipoprotein_level1.83749387
31MP0008007_abnormal_cellular_replicative1.80068356
32MP0000566_synostosis1.75857993
33MP0008932_abnormal_embryonic_tissue1.75708643
34MP0003693_abnormal_embryo_hatching1.70761710
35MP0000569_abnormal_digit_pigmentation1.69866296
36MP0003195_calcinosis1.68097291
37MP0005408_hypopigmentation1.62359841
38MP0009053_abnormal_anal_canal1.62071741
39MP0003950_abnormal_plasma_membrane1.62035327
40MP0006276_abnormal_autonomic_nervous1.54345132
41MP0009250_abnormal_appendicular_skeleto1.54154012
42MP0010368_abnormal_lymphatic_system1.50815638
43MP0010234_abnormal_vibrissa_follicle1.50811675
44MP0005187_abnormal_penis_morphology1.49359082
45MP0003121_genomic_imprinting1.46709271
46MP0003136_yellow_coat_color1.46697822
47MP0005332_abnormal_amino_acid1.44521099
48MP0004019_abnormal_vitamin_homeostasis1.42774956
49MP0003283_abnormal_digestive_organ1.41157257
50MP0005248_abnormal_Harderian_gland1.40423154
51MP0010678_abnormal_skin_adnexa1.39280837
52MP0004043_abnormal_pH_regulation1.38029111
53MP0002396_abnormal_hematopoietic_system1.37875830
54MP0005379_endocrine/exocrine_gland_phen1.37377748
55MP0003937_abnormal_limbs/digits/tail_de1.36492708
56MP0005646_abnormal_pituitary_gland1.36200911
57MP0002837_dystrophic_cardiac_calcinosis1.34725222
58MP0000678_abnormal_parathyroid_gland1.34718433
59MP0005275_abnormal_skin_tensile1.33003143
60MP0003890_abnormal_embryonic-extraembry1.32350667
61MP0001188_hyperpigmentation1.32147754
62MP0002177_abnormal_outer_ear1.31539346
63MP0005197_abnormal_uvea_morphology1.30472829
64MP0001944_abnormal_pancreas_morphology1.30453581
65MP0003011_delayed_dark_adaptation1.27902702
66MP0000613_abnormal_salivary_gland1.27660995
67MP0006054_spinal_hemorrhage1.25606402
68MP0002118_abnormal_lipid_homeostasis1.24672852
69MP0002163_abnormal_gland_morphology1.23200037
70MP0010030_abnormal_orbit_morphology1.22907670
71MP0010307_abnormal_tumor_latency1.20366116
72MP0005551_abnormal_eye_electrophysiolog1.20002981
73MP0005174_abnormal_tail_pigmentation1.19821026
74MP0003942_abnormal_urinary_system1.18591290
75MP0001661_extended_life_span1.16009336
76MP0000350_abnormal_cell_proliferation1.14826007
77MP0002009_preneoplasia1.14077910
78MP0002938_white_spotting1.13173786
79MP0002084_abnormal_developmental_patter1.11951464
80MP0004185_abnormal_adipocyte_glucose1.11630508
81MP0002060_abnormal_skin_morphology1.11269890
82MP0001697_abnormal_embryo_size1.11159844
83MP0000428_abnormal_craniofacial_morphol1.10170548
84MP0000015_abnormal_ear_pigmentation1.09945401
85MP0003786_premature_aging1.09047850
86MP0000371_diluted_coat_color1.08515399
87MP0000163_abnormal_cartilage_morphology1.07435915
88MP0001730_embryonic_growth_arrest1.05548197
89MP0002697_abnormal_eye_size1.05518463
90MP0009780_abnormal_chondrocyte_physiolo1.05056895
91MP0004134_abnormal_chest_morphology1.04601350
92MP0002234_abnormal_pharynx_morphology1.04305546
93MP0001672_abnormal_embryogenesis/_devel1.04302007
94MP0005380_embryogenesis_phenotype1.04302007
95MP0000516_abnormal_urinary_system1.03708530
96MP0005367_renal/urinary_system_phenotyp1.03708530
97MP0003385_abnormal_body_wall1.03132894
98MP0000383_abnormal_hair_follicle1.02984798
99MP0005084_abnormal_gallbladder_morpholo1.02670254
100MP0002115_abnormal_skeleton_extremities1.02323120
101MP0005666_abnormal_adipose_tissue1.00547172
102MP0005075_abnormal_melanosome_morpholog0.99088149
103MP0002078_abnormal_glucose_homeostasis0.98943328
104MP0003755_abnormal_palate_morphology0.97941949
105MP0004145_abnormal_muscle_electrophysio0.97728243
106MP0002896_abnormal_bone_mineralization0.97387478
107MP0000013_abnormal_adipose_tissue0.96994260
108MP0003984_embryonic_growth_retardation0.95812988
109MP0005595_abnormal_vascular_smooth0.95671824
110MP0009384_cardiac_valve_regurgitation0.95635279
111MP0000358_abnormal_cell_content/0.95509819
112MP0002233_abnormal_nose_morphology0.94933676
113MP0002088_abnormal_embryonic_growth/wei0.94136281
114MP0002295_abnormal_pulmonary_circulatio0.92872567
115MP0002095_abnormal_skin_pigmentation0.92483872
116MP0000462_abnormal_digestive_system0.91651236
117MP0009672_abnormal_birth_weight0.91252202
118MP0000432_abnormal_head_morphology0.89958814
119MP0001270_distended_abdomen0.88453787
120MP0004272_abnormal_basement_membrane0.87739094
121MP0005395_other_phenotype0.87727635
122MP0003718_maternal_effect0.86960924
123MP0001764_abnormal_homeostasis0.86878391
124MP0004233_abnormal_muscle_weight0.86145031
125MP0000639_abnormal_adrenal_gland0.86125541
126MP0004197_abnormal_fetal_growth/weight/0.85999565
127MP0003943_abnormal_hepatobiliary_system0.85849062
128MP0002085_abnormal_embryonic_tissue0.85472905
129MP0002102_abnormal_ear_morphology0.85194863
130MP0002168_other_aberrant_phenotype0.85127006
131MP0001299_abnormal_eye_distance/0.84746866
132MP0000762_abnormal_tongue_morphology0.82948288
133MP0002109_abnormal_limb_morphology0.82106045
134MP0000609_abnormal_liver_physiology0.82080994
135MP0002249_abnormal_larynx_morphology0.80969183
136MP0006138_congestive_heart_failure0.80910787
137MP0001286_abnormal_eye_development0.80555828
138MP0002160_abnormal_reproductive_system0.79932053
139MP0002086_abnormal_extraembryonic_tissu0.79888456
140MP0006292_abnormal_olfactory_placode0.79876880
141MP0004808_abnormal_hematopoietic_stem0.79821916
142MP0001186_pigmentation_phenotype0.79734108
143MP0009703_decreased_birth_body0.79654033
144MP0000647_abnormal_sebaceous_gland0.79332880
145MP0002075_abnormal_coat/hair_pigmentati0.79330684
146MP0003935_abnormal_craniofacial_develop0.79041051
147MP0006036_abnormal_mitochondrial_physio0.78823968
148MP0004215_abnormal_myocardial_fiber0.78632625
149MP0002080_prenatal_lethality0.78317935
150MP0003878_abnormal_ear_physiology0.77659668
151MP0005377_hearing/vestibular/ear_phenot0.77659668
152MP0000049_abnormal_middle_ear0.77447829
153MP0005647_abnormal_sex_gland0.77066659
154MP0004133_heterotaxia0.76863564
155MP0002113_abnormal_skeleton_development0.76616828
156MP0001984_abnormal_olfaction0.75285658
157MP0002089_abnormal_postnatal_growth/wei0.75233592
158MP0005636_abnormal_mineral_homeostasis0.71946184
159MP0005319_abnormal_enzyme/_coenzyme0.70398468
160MP0000003_abnormal_adipose_tissue0.70140152
161MP0003646_muscle_fatigue0.69958017
162MP0005334_abnormal_fat_pad0.69455658
163MP0003279_aneurysm0.69124539
164MP0009643_abnormal_urine_homeostasis0.68874566
165MP0002932_abnormal_joint_morphology0.68028612
166MP0002693_abnormal_pancreas_physiology0.67985551
167MP0001879_abnormal_lymphatic_vessel0.67152081
168MP0010386_abnormal_urinary_bladder0.65853294
169MP0002108_abnormal_muscle_morphology0.65489113
170MP0005508_abnormal_skeleton_morphology0.65248061
171MP0002269_muscular_atrophy0.64272761
172MP0003959_abnormal_lean_body0.63170576
173MP0002116_abnormal_craniofacial_bone0.61001441
174MP0001293_anophthalmia0.60875439
175MP0001324_abnormal_eye_pigmentation0.60538846
176MP0005253_abnormal_eye_physiology0.59600933

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.94564041
2Hypoglycemic seizures (HP:0002173)4.68340859
3Hypoglycemic coma (HP:0001325)4.43237216
4Hyperinsulinemic hypoglycemia (HP:0000825)4.09452379
5Ketosis (HP:0001946)3.79327391
6Deep venous thrombosis (HP:0002625)3.70711913
7Intrahepatic cholestasis (HP:0001406)3.66009906
8Symptomatic seizures (HP:0011145)3.57881523
9Volvulus (HP:0002580)3.38597313
10Hypobetalipoproteinemia (HP:0003563)3.38045103
11Ketoacidosis (HP:0001993)3.33855898
12Chromsome breakage (HP:0040012)3.29743210
13Conjugated hyperbilirubinemia (HP:0002908)3.27370811
14Abnormality of the intrinsic pathway (HP:0010989)3.22522990
15Abnormality of chromosome stability (HP:0003220)3.16401913
16Renal cortical cysts (HP:0000803)3.03504593
17Prolonged partial thromboplastin time (HP:0003645)3.00189968
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.99754446
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93214357
20Xanthomatosis (HP:0000991)2.90892623
21Abnormality of the common coagulation pathway (HP:0010990)2.89411774
22Protrusio acetabuli (HP:0003179)2.84104162
23Congenital sensorineural hearing impairment (HP:0008527)2.82951500
24Enlarged kidneys (HP:0000105)2.82370002
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.82009456
26Long clavicles (HP:0000890)2.80536770
27Patchy hypopigmentation of hair (HP:0011365)2.79096214
28Hypolipoproteinemia (HP:0010981)2.67078574
29Abnormality of fatty-acid metabolism (HP:0004359)2.66528883
30Fat malabsorption (HP:0002630)2.66003154
31Abnormality of the anterior horn cell (HP:0006802)2.65305440
32Degeneration of anterior horn cells (HP:0002398)2.65305440
33Hyperammonemia (HP:0001987)2.57236842
34Hyperglycinemia (HP:0002154)2.52289496
35Delayed CNS myelination (HP:0002188)2.48432635
36Turricephaly (HP:0000262)2.47981379
37Hyperglycemia (HP:0003074)2.45330244
38Osteomalacia (HP:0002749)2.45318723
39Hypoalphalipoproteinemia (HP:0003233)2.40807344
40Tubulointerstitial nephritis (HP:0001970)2.40387428
41Abnormality of the astrocytes (HP:0100707)2.39989992
42Astrocytoma (HP:0009592)2.39989992
43Vitreoretinal degeneration (HP:0000655)2.38944615
44Abnormal auditory evoked potentials (HP:0006958)2.38429052
45Abnormality of the lower motor neuron (HP:0002366)2.35648146
46Microglossia (HP:0000171)2.34526914
47Bell-shaped thorax (HP:0001591)2.34091009
48Rhabdomyosarcoma (HP:0002859)2.33874517
49Brushfield spots (HP:0001088)2.33466158
50Premature rupture of membranes (HP:0001788)2.32838805
51White forelock (HP:0002211)2.31889715
52Abnormal umbilical cord blood vessels (HP:0011403)2.27853560
53Single umbilical artery (HP:0001195)2.27853560
54Abnormality of the fetal cardiovascular system (HP:0010948)2.27853560
55Steatorrhea (HP:0002570)2.27216371
56Hyperlipoproteinemia (HP:0010980)2.27000234
57Abnormal rod and cone electroretinograms (HP:0008323)2.26371571
58Opisthotonus (HP:0002179)2.24207141
59Curly hair (HP:0002212)2.24099660
60Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22666252
61Osteolytic defects of the hand bones (HP:0009699)2.22493172
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.22493172
63Intestinal atresia (HP:0011100)2.21247404
64Abnormality of the duodenum (HP:0002246)2.20412657
65Cholecystitis (HP:0001082)2.19402696
66Abnormal gallbladder physiology (HP:0012438)2.19402696
67Decreased central vision (HP:0007663)2.18127774
68Abnormality of methionine metabolism (HP:0010901)2.17290824
69Hyperactive renin-angiotensin system (HP:0000841)2.16194556
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15181254
71Late onset (HP:0003584)2.14250021
72Hyperbilirubinemia (HP:0002904)2.13641879
73Small intestinal stenosis (HP:0012848)2.13536767
74Duodenal stenosis (HP:0100867)2.13536767
75Abnormality of serum amino acid levels (HP:0003112)2.13101843
76Abnormal lung lobation (HP:0002101)2.13032017
77Papillary thyroid carcinoma (HP:0002895)2.12453526
78Abnormality of the preputium (HP:0100587)2.12330270
79Glioma (HP:0009733)2.07608010
80Gastrointestinal atresia (HP:0002589)2.06946961
81Proximal tubulopathy (HP:0000114)2.06543903
82Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06492268
83Cardiovascular calcification (HP:0011915)2.05113908
84Absent eyebrow (HP:0002223)2.03000125
85Abnormality of the fovea (HP:0000493)2.02652701
86Coronal craniosynostosis (HP:0004440)2.02368726
87Arterial tortuosity (HP:0005116)2.02357855
88Abnormality of alanine metabolism (HP:0010916)1.99626440
89Hyperalaninemia (HP:0003348)1.99626440
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99626440
91Bile duct proliferation (HP:0001408)1.98845118
92Abnormal biliary tract physiology (HP:0012439)1.98845118
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98480561
94Progressive external ophthalmoplegia (HP:0000590)1.97626907
95Popliteal pterygium (HP:0009756)1.95764135
96Submucous cleft hard palate (HP:0000176)1.95576836
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.94439038
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.94286026
99Generalized aminoaciduria (HP:0002909)1.94220540
100Metabolic acidosis (HP:0001942)1.93884264
101Cystic hygroma (HP:0000476)1.93341322
102Breech presentation (HP:0001623)1.93186080
103Median cleft lip (HP:0000161)1.92446310
104Increased nuchal translucency (HP:0010880)1.91938063
105Facial cleft (HP:0002006)1.91640751
106Vascular calcification (HP:0004934)1.91484644
107Abnormality of glycine metabolism (HP:0010895)1.89965042
108Abnormality of serine family amino acid metabolism (HP:0010894)1.89965042
109Beaking of vertebral bodies (HP:0004568)1.89320606
110Meckel diverticulum (HP:0002245)1.89205878
111Absent eyelashes (HP:0000561)1.88488234
112Deep philtrum (HP:0002002)1.88007162
113Abnormality of purine metabolism (HP:0004352)1.86392732
114Hypoplastic ischia (HP:0003175)1.86108438
115Complement deficiency (HP:0004431)1.85588098
116Conjunctival telangiectasia (HP:0000524)1.85456631
117Mitral stenosis (HP:0001718)1.84201119
118Pancreatic islet-cell hyperplasia (HP:0004510)1.84002961
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.83819384
120Insulin-resistant diabetes mellitus (HP:0000831)1.83361292
121Flat face (HP:0012368)1.83190421
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.82773525
123Hypoplasia of the fovea (HP:0007750)1.82773525
124Freckling (HP:0001480)1.82480883
125Chronic hepatic failure (HP:0100626)1.82253077
126Follicular hyperkeratosis (HP:0007502)1.81414288
127Abnormality of the pancreatic islet cells (HP:0006476)1.81348986
128Abnormality of endocrine pancreas physiology (HP:0012093)1.81348986
129Dicarboxylic aciduria (HP:0003215)1.80295616
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80295616
131Cerebral edema (HP:0002181)1.80288353
132Joint hemorrhage (HP:0005261)1.80102643
133Ankyloglossia (HP:0010296)1.80068442
134Acute myeloid leukemia (HP:0004808)1.80018350
135Neoplasm of the peripheral nervous system (HP:0100007)1.79437591
136Hepatoblastoma (HP:0002884)1.79146520
137Unilateral renal agenesis (HP:0000122)1.78013185
138Abnormality of the umbilical cord (HP:0010881)1.77998842
139Thyroiditis (HP:0100646)1.77298929
140Vascular tortuosity (HP:0004948)1.77171239
141Birth length less than 3rd percentile (HP:0003561)1.76944255
142Epiphyseal stippling (HP:0010655)1.76670240
143Cutaneous melanoma (HP:0012056)1.76613423
144Abnormality of the ileum (HP:0001549)1.75274963
145Myelodysplasia (HP:0002863)1.74568946
146Sloping forehead (HP:0000340)1.74503909
147Nephroblastoma (Wilms tumor) (HP:0002667)1.73939366
148Abnormality of the renal cortex (HP:0011035)1.72399464
149Relative macrocephaly (HP:0004482)1.71948917
150Embryonal renal neoplasm (HP:0011794)1.71913109
151Abnormality of glycolysis (HP:0004366)1.71701841
152Epidermoid cyst (HP:0200040)1.71683588
153Abnormality of the ischium (HP:0003174)1.71209721
154Anal atresia (HP:0002023)1.71111193
155Adrenal hypoplasia (HP:0000835)1.71055541
156Pancreatic fibrosis (HP:0100732)1.70702072
157Chorioretinal atrophy (HP:0000533)1.70553892
158Abnormality of nucleobase metabolism (HP:0010932)1.69758624
159Ependymoma (HP:0002888)1.69330281
160Urethral obstruction (HP:0000796)1.69058045
161Horizontal nystagmus (HP:0000666)1.68838533
162Gout (HP:0001997)1.68410623
163Bony spicule pigmentary retinopathy (HP:0007737)1.68240990
164Soft skin (HP:0000977)1.67533639
165Acute encephalopathy (HP:0006846)1.67129133
166Ectopia lentis (HP:0001083)1.66719554
167Hydroxyprolinuria (HP:0003080)1.66593688
168Bilateral sensorineural hearing impairment (HP:0008619)1.64290610
169Preaxial hand polydactyly (HP:0001177)1.63367305
170Short middle phalanx of the 5th finger (HP:0004220)1.62999145
171Clubbing of toes (HP:0100760)1.62873415
172Esophageal atresia (HP:0002032)1.61327234
173Pulmonic stenosis (HP:0001642)1.58035178
174Abnormality of the carotid arteries (HP:0005344)1.56377481
175Atrophic scars (HP:0001075)1.55889552
176Metaphyseal dysplasia (HP:0100255)1.55627788
177Neoplasm of the small intestine (HP:0100833)1.55472717
178Postaxial foot polydactyly (HP:0001830)1.54271320
179Short tibia (HP:0005736)1.53730225
180Increased serum pyruvate (HP:0003542)1.53590593
181Prominent nose (HP:0000448)1.53185782
182Supernumerary spleens (HP:0009799)1.52813224
183Aplasia/Hypoplasia of the tibia (HP:0005772)1.51813854
184Abnormalities of placenta or umbilical cord (HP:0001194)1.51531567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.79575981
2INSRR4.57055566
3BCKDK4.11738920
4SIK13.72158473
5BUB13.40014589
6CDK83.35813742
7MKNK23.14167563
8MKNK13.12322196
9PBK3.08947852
10WEE12.92383808
11EIF2AK32.89586004
12PINK12.88578520
13NEK12.52873766
14TRIM282.50395842
15ERBB32.48635420
16BRSK22.47647256
17MAPK152.31631988
18MST42.20506665
19EIF2AK12.08686644
20PLK32.07409886
21TSSK62.01308273
22TTK1.95531634
23STK38L1.94826587
24TAF11.94670412
25GRK11.89345339
26TAOK31.82943115
27STK391.78712120
28DDR21.75461860
29ERN11.74509451
30SIK31.73146109
31STK31.72016816
32BCR1.71189140
33PRKD31.71005204
34LATS11.68691529
35PASK1.59682565
36PNCK1.59048819
37LATS21.58936422
38PLK21.53934804
39ZAK1.51962308
40MST1R1.46060298
41BRD41.45421092
42MAPK131.42774874
43PLK41.41847527
44CDC71.41337071
45CDK61.41017121
46KDR1.33594189
47ACVR1B1.33100909
48MAPK111.32539249
49PLK11.29794895
50PIK3CG1.29339593
51CAMK1D1.28967662
52FRK1.28843509
53OBSCN1.24307397
54MAPKAPK51.22706007
55FER1.19947547
56FLT31.16694970
57SCYL21.15565755
58TEC1.13712295
59BRSK11.13149662
60CAMK1G1.11338076
61PRKAA21.10223035
62MAP2K41.08821653
63BMX1.06505498
64PTK21.04654810
65STK241.03919330
66EIF2AK21.01706855
67BRAF1.01436967
68PTK2B1.00749065
69TGFBR10.97307397
70BMPR1B0.97043678
71MARK30.96590731
72ERBB40.96056273
73PRKD20.94277754
74MAP3K110.93670721
75MOS0.92115812
76CASK0.91017227
77TESK10.90263968
78NEK90.89465336
79CCNB10.89234492
80BMPR20.88164983
81PDGFRA0.88000100
82VRK10.87328942
83PIK3CA0.83182153
84PAK30.82121733
85KSR10.81593161
86SRPK10.79557739
87ATM0.74271917
88TAOK20.72987599
89LIMK10.72165480
90PKN20.72079076
91MAP3K60.71456251
92MAP3K120.70140060
93CHEK20.69106025
94ATR0.68496447
95MAPKAPK30.67382147
96TGFBR20.67153903
97AURKB0.66826032
98MAP2K20.66807958
99PDK20.65017956
100MAP4K20.64215776
101TRPM70.63781086
102EPHA30.62562779
103STK160.61568349
104MAP2K10.59391154
105CHEK10.59039959
106CLK10.58386786
107CAMK2G0.56214357
108YES10.54862458
109DMPK0.53126318
110AKT30.50434698
111PRKAA10.49548508
112CSNK1G10.47859056
113SGK20.47353572
114NLK0.46527877
115MAP2K70.46296693
116CDK70.45532379
117PHKG10.44975514
118PHKG20.44975514
119ARAF0.44923746
120MYLK0.44834077
121MINK10.44518908
122HIPK20.44071141
123CAMK2D0.43891531
124STK40.42883112
125STK100.42628062
126SGK2230.42550487
127SGK4940.42550487
128PAK20.42497302
129PRKCE0.41569698
130CAMK2A0.40282423
131CAMK10.39294249
132MAP3K50.38919335
133NUAK10.38686327
134PRKD10.38429832
135CSNK1A1L0.37332434
136TNIK0.36869572
137WNK40.36738550
138DYRK20.36517644
139TRIB30.35838286
140MELK0.35749554
141RPS6KB10.34996241
142CSNK1G20.34190178
143EPHB20.32902881
144MARK20.32874425
145RET0.32337525
146MAP3K20.32177541
147MAP3K90.31339275
148FGFR10.31031357
149MET0.30566092
150ERBB20.30537112
151MAP3K10.30484292
152CDK10.30033751
153RPS6KA40.29510974
154PRKCI0.29415543
155RPS6KB20.29094397
156CSNK1G30.29066107
157CSNK1E0.28990389
158PRKCH0.28936960
159MAPK70.28208516
160MAP3K130.27791353
161WNK30.27391613
162IGF1R0.27192593
163MAP3K30.26023578

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.27012083
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.01456284
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.96118940
4Proteasome_Homo sapiens_hsa030502.72871903
5Mismatch repair_Homo sapiens_hsa034302.66178338
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62560597
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61155345
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60352341
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44932388
10Cell cycle_Homo sapiens_hsa041102.37319080
11Propanoate metabolism_Homo sapiens_hsa006402.32438160
12Tryptophan metabolism_Homo sapiens_hsa003802.29597080
13Homologous recombination_Homo sapiens_hsa034402.28561141
14DNA replication_Homo sapiens_hsa030302.26636349
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19285985
16Folate biosynthesis_Homo sapiens_hsa007902.16548784
17Fanconi anemia pathway_Homo sapiens_hsa034602.12331571
18Fatty acid degradation_Homo sapiens_hsa000712.09750987
19Sulfur relay system_Homo sapiens_hsa041222.09702909
20Peroxisome_Homo sapiens_hsa041462.03272077
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03086776
22Sulfur metabolism_Homo sapiens_hsa009201.96932960
23Arginine biosynthesis_Homo sapiens_hsa002201.96474815
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95801487
25Protein export_Homo sapiens_hsa030601.94260531
26RNA transport_Homo sapiens_hsa030131.90514412
27Nucleotide excision repair_Homo sapiens_hsa034201.85946862
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84356737
29Nitrogen metabolism_Homo sapiens_hsa009101.84351313
30Fatty acid metabolism_Homo sapiens_hsa012121.78592788
31Basal transcription factors_Homo sapiens_hsa030221.75163128
32Histidine metabolism_Homo sapiens_hsa003401.70520226
33Selenocompound metabolism_Homo sapiens_hsa004501.69323482
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63308227
35Butanoate metabolism_Homo sapiens_hsa006501.61873344
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.60340987
37Complement and coagulation cascades_Homo sapiens_hsa046101.58733351
38beta-Alanine metabolism_Homo sapiens_hsa004101.58646896
39Arginine and proline metabolism_Homo sapiens_hsa003301.57285898
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54133105
41Phenylalanine metabolism_Homo sapiens_hsa003601.53231914
42TGF-beta signaling pathway_Homo sapiens_hsa043501.52116811
43Fatty acid elongation_Homo sapiens_hsa000621.51302921
44Tyrosine metabolism_Homo sapiens_hsa003501.51285541
45Oocyte meiosis_Homo sapiens_hsa041141.47836047
46RNA degradation_Homo sapiens_hsa030181.46569364
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45502550
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43240436
49Starch and sucrose metabolism_Homo sapiens_hsa005001.42119277
50Pyruvate metabolism_Homo sapiens_hsa006201.41002820
51PPAR signaling pathway_Homo sapiens_hsa033201.39730738
52Base excision repair_Homo sapiens_hsa034101.37518189
53p53 signaling pathway_Homo sapiens_hsa041151.36016539
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33707362
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.32370142
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29896182
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29057489
58RNA polymerase_Homo sapiens_hsa030201.23464726
59Steroid biosynthesis_Homo sapiens_hsa001001.19918252
60Bile secretion_Homo sapiens_hsa049761.19288532
61Fat digestion and absorption_Homo sapiens_hsa049751.17392792
62Vitamin digestion and absorption_Homo sapiens_hsa049771.12070601
63Pyrimidine metabolism_Homo sapiens_hsa002401.09944035
64Chemical carcinogenesis_Homo sapiens_hsa052041.09921183
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09733054
66mRNA surveillance pathway_Homo sapiens_hsa030151.09293269
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09291087
68Spliceosome_Homo sapiens_hsa030401.04763786
69Retinol metabolism_Homo sapiens_hsa008301.04147138
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03805787
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03747999
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02221928
73Hippo signaling pathway_Homo sapiens_hsa043900.99697936
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.97611662
75Protein digestion and absorption_Homo sapiens_hsa049740.94354472
76Hedgehog signaling pathway_Homo sapiens_hsa043400.90978674
77Ovarian steroidogenesis_Homo sapiens_hsa049130.88405691
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87819480
79Purine metabolism_Homo sapiens_hsa002300.86948184
80Carbon metabolism_Homo sapiens_hsa012000.83897329
81Biosynthesis of amino acids_Homo sapiens_hsa012300.83478170
82Fructose and mannose metabolism_Homo sapiens_hsa000510.80484598
83Lysine degradation_Homo sapiens_hsa003100.79683316
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78802604
85ABC transporters_Homo sapiens_hsa020100.76414521
86Adherens junction_Homo sapiens_hsa045200.75109290
87Insulin secretion_Homo sapiens_hsa049110.73546464
88Small cell lung cancer_Homo sapiens_hsa052220.72287918
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71941506
90Melanoma_Homo sapiens_hsa052180.71903233
91Linoleic acid metabolism_Homo sapiens_hsa005910.71715309
92Galactose metabolism_Homo sapiens_hsa000520.71110773
93Glycerolipid metabolism_Homo sapiens_hsa005610.70605793
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70052728
95Metabolic pathways_Homo sapiens_hsa011000.68369443
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67676952
97Pancreatic secretion_Homo sapiens_hsa049720.67402881
98N-Glycan biosynthesis_Homo sapiens_hsa005100.66621848
99Renin-angiotensin system_Homo sapiens_hsa046140.65553005
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63365140
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62541826
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61468843
103MicroRNAs in cancer_Homo sapiens_hsa052060.61042518
104Proteoglycans in cancer_Homo sapiens_hsa052050.60925454
105Glucagon signaling pathway_Homo sapiens_hsa049220.59273425
106Sphingolipid metabolism_Homo sapiens_hsa006000.57571886
107Caffeine metabolism_Homo sapiens_hsa002320.56826489
108Circadian rhythm_Homo sapiens_hsa047100.55613457
109One carbon pool by folate_Homo sapiens_hsa006700.54398196
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53583718
111Fatty acid biosynthesis_Homo sapiens_hsa000610.51345622
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47686348
113Glioma_Homo sapiens_hsa052140.44192486
114Glutathione metabolism_Homo sapiens_hsa004800.44022640
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43568531
116Wnt signaling pathway_Homo sapiens_hsa043100.41622291
117Phototransduction_Homo sapiens_hsa047440.41136135
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39203132
119Oxidative phosphorylation_Homo sapiens_hsa001900.35711148
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35618076
121Thyroid cancer_Homo sapiens_hsa052160.34404819
122Focal adhesion_Homo sapiens_hsa045100.32949540
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32408335
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32126770
125Alcoholism_Homo sapiens_hsa050340.31880414
126Colorectal cancer_Homo sapiens_hsa052100.30877269
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28975551
128Prion diseases_Homo sapiens_hsa050200.28355564
129AMPK signaling pathway_Homo sapiens_hsa041520.28115670
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27357963
131Inositol phosphate metabolism_Homo sapiens_hsa005620.27332936
132Basal cell carcinoma_Homo sapiens_hsa052170.26929233
133ECM-receptor interaction_Homo sapiens_hsa045120.26674945
134Taste transduction_Homo sapiens_hsa047420.25814101
135Insulin resistance_Homo sapiens_hsa049310.25554713
136Prostate cancer_Homo sapiens_hsa052150.25292346
137Tight junction_Homo sapiens_hsa045300.24141163
138Other glycan degradation_Homo sapiens_hsa005110.23553135
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23339800
140Vitamin B6 metabolism_Homo sapiens_hsa007500.22224503
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21958408
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21821276
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19936134
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17636777
145Cardiac muscle contraction_Homo sapiens_hsa042600.17595269

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