GPR183

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.98779803
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.57187082
3negative regulation of cell killing (GO:0031342)5.57187082
4negative thymic T cell selection (GO:0045060)5.51192233
5negative T cell selection (GO:0043383)5.46651510
6regulation of B cell receptor signaling pathway (GO:0050855)5.36322149
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.26460761
8antigen processing and presentation of endogenous antigen (GO:0019883)5.18492524
9NIK/NF-kappaB signaling (GO:0038061)5.01761716
10regulation of gamma-delta T cell differentiation (GO:0045586)4.97623999
11positive thymic T cell selection (GO:0045059)4.84920228
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.82805696
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.82128992
14cellular response to interleukin-15 (GO:0071350)4.74964946
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72314050
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.72314050
17tolerance induction (GO:0002507)4.63831824
18response to interleukin-15 (GO:0070672)4.62231439
19regulation of gamma-delta T cell activation (GO:0046643)4.59116762
20positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.57733623
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56532062
22regulation of T cell tolerance induction (GO:0002664)4.52714129
23interferon-gamma production (GO:0032609)4.47414377
24thymic T cell selection (GO:0045061)4.43009619
25regulation of hypersensitivity (GO:0002883)4.33679033
26response to peptidoglycan (GO:0032494)4.28834536
27B cell mediated immunity (GO:0019724)4.22767942
28myeloid dendritic cell activation (GO:0001773)4.21123223
29myeloid dendritic cell differentiation (GO:0043011)4.17513967
30positive T cell selection (GO:0043368)4.12735771
31T cell selection (GO:0045058)4.09750304
32negative regulation of interleukin-12 production (GO:0032695)4.01829408
33T cell migration (GO:0072678)4.00955025
34B cell receptor signaling pathway (GO:0050853)3.89008593
35regulation of B cell differentiation (GO:0045577)3.78565133
36positive regulation of mast cell activation (GO:0033005)3.78534168
37positive regulation of interleukin-2 production (GO:0032743)3.78058601
38response to muramyl dipeptide (GO:0032495)3.76659079
39neutrophil activation involved in immune response (GO:0002283)3.69946563
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.67402731
41positive regulation of mast cell degranulation (GO:0043306)3.67402731
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.65050005
43regulation of interleukin-2 biosynthetic process (GO:0045076)3.64129606
44positive regulation of antigen processing and presentation (GO:0002579)3.63914323
45positive regulation of B cell differentiation (GO:0045579)3.63830526
46regulation of isotype switching to IgG isotypes (GO:0048302)3.59286623
47regulation of alpha-beta T cell proliferation (GO:0046640)3.55008851
48regulation of tolerance induction (GO:0002643)3.53891295
49regulation of interferon-beta biosynthetic process (GO:0045357)3.53587839
50T cell costimulation (GO:0031295)3.52095620
51regulation of chronic inflammatory response (GO:0002676)3.51271725
52leukocyte aggregation (GO:0070486)3.49205989
53lymphocyte costimulation (GO:0031294)3.47458453
54regulation of inflammatory response to antigenic stimulus (GO:0002861)3.45875486
55antigen receptor-mediated signaling pathway (GO:0050851)3.40502610
56cellular response to interferon-gamma (GO:0071346)3.40434036
57T-helper cell differentiation (GO:0042093)3.40042385
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.40042385
59interferon-gamma-mediated signaling pathway (GO:0060333)3.36784019
60neutrophil activation (GO:0042119)3.36087345
61positive regulation of B cell mediated immunity (GO:0002714)3.35455241
62positive regulation of immunoglobulin mediated immune response (GO:0002891)3.35455241
63T cell receptor signaling pathway (GO:0050852)3.35234606
64positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.33781469
65negative regulation of T cell mediated immunity (GO:0002710)3.29617106
66negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.28787076
67regulation of T-helper 1 cell differentiation (GO:0045625)3.28224888
68dendritic cell differentiation (GO:0097028)3.27546973
69regulation of natural killer cell mediated immunity (GO:0002715)3.27279907
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.27279907
71germinal center formation (GO:0002467)3.26490418
72positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.26375827
73regulation of mast cell activation (GO:0033003)3.25240673
74immunoglobulin mediated immune response (GO:0016064)3.22990905
75defense response to protozoan (GO:0042832)3.22487135
76positive regulation of natural killer cell mediated immunity (GO:0002717)3.18521403
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.18521403
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.18345708
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16602935
80regulation of T cell receptor signaling pathway (GO:0050856)3.16558158
81positive regulation of interleukin-12 production (GO:0032735)3.16364391
82regulation of antigen processing and presentation (GO:0002577)3.16197125
83regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15907261
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14328290
85positive regulation of isotype switching (GO:0045830)3.13952926
86granulocyte activation (GO:0036230)3.11132105
87regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.10677425
88regulation of germinal center formation (GO:0002634)3.09792947
89regulation of response to interferon-gamma (GO:0060330)3.09721947
90response to interferon-gamma (GO:0034341)3.07929273
91negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.07888741
92detection of other organism (GO:0098543)3.07801557
93regulation of mast cell degranulation (GO:0043304)3.07636301
94response to protozoan (GO:0001562)3.06450484
95detection of bacterium (GO:0016045)3.06332935
96regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.06073995
97mast cell activation (GO:0045576)3.06041329
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.05970337
99production of molecular mediator of immune response (GO:0002440)3.05767377
100negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.05306926
101positive regulation of interferon-alpha production (GO:0032727)3.03780051
102negative regulation of bone resorption (GO:0045779)3.03561385
103regulation of interferon-alpha production (GO:0032647)3.03539167
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.03270273
105T cell differentiation involved in immune response (GO:0002292)3.02663014
106alpha-beta T cell differentiation involved in immune response (GO:0002293)3.02663014
107alpha-beta T cell activation involved in immune response (GO:0002287)3.02663014
108microglial cell activation (GO:0001774)3.02171635
109modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01424406
110positive regulation by organism of defense response of other organism involved in symbiotic interact3.01424406
111modulation by symbiont of host immune response (GO:0052553)3.01424406
112positive regulation by symbiont of host defense response (GO:0052509)3.01424406
113modulation by symbiont of host defense response (GO:0052031)3.01424406
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01424406
115regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.01409568
116regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.01185400
117* mature B cell differentiation (GO:0002335)3.01004844
118negative regulation of granulocyte differentiation (GO:0030853)2.97773801
119response to type I interferon (GO:0034340)2.97324876
120macrophage activation involved in immune response (GO:0002281)2.96873607
121type I interferon signaling pathway (GO:0060337)2.96848821
122cellular response to type I interferon (GO:0071357)2.96848821
123regulation of interleukin-12 production (GO:0032655)2.94572104
124cellular response to zinc ion (GO:0071294)2.94566835
125positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.93927484
126positive regulation of interferon-gamma production (GO:0032729)2.91599788
127regulation of regulatory T cell differentiation (GO:0045589)2.90676662
128natural killer cell activation (GO:0030101)2.90573008
129antigen processing and presentation via MHC class Ib (GO:0002475)2.90143611
130T cell activation involved in immune response (GO:0002286)2.89993361
131positive regulation of chemokine biosynthetic process (GO:0045080)2.88843932
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87382044
133positive regulation of humoral immune response (GO:0002922)2.86025044
134myeloid cell activation involved in immune response (GO:0002275)2.85686438
135regulation of mast cell activation involved in immune response (GO:0033006)2.84613184
136regulation of chemokine biosynthetic process (GO:0045073)2.84041779
137positive regulation of type 2 immune response (GO:0002830)2.81890379
138negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.81004651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.35234020
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.81501001
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.50039636
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.60443969
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53113282
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10270606
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.04103498
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.63875223
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48395791
10RUNX_20019798_ChIP-Seq_JUKART_Human3.43492454
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39071493
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.32040594
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.26284715
14* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.21853509
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13730062
16BP1_19119308_ChIP-ChIP_Hs578T_Human3.07733468
17EGR1_19374776_ChIP-ChIP_THP-1_Human3.05125198
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88524520
19* MYB_26560356_Chip-Seq_TH2_Human2.87675324
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82489920
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66608730
22MYC_22102868_ChIP-Seq_BL_Human2.63677309
23MAF_26560356_Chip-Seq_TH1_Human2.61302810
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.49726459
25MYB_26560356_Chip-Seq_TH1_Human2.45593320
26SCL_19346495_ChIP-Seq_HPC-7_Human2.43910406
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37843792
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25160732
29SPI1_23547873_ChIP-Seq_NB4_Human2.21745537
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11677334
31VDR_21846776_ChIP-Seq_THP-1_Human2.06444320
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.03036872
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01020842
34UTX_26944678_Chip-Seq_JUKART_Human1.98797348
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97064886
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92888426
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91868839
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89672426
39VDR_24763502_ChIP-Seq_THP-1_Human1.87378561
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84976423
41TCF7_22412390_ChIP-Seq_EML_Mouse1.83411778
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.76321446
43SPI1_23127762_ChIP-Seq_K562_Human1.70587425
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68494906
45* MAF_26560356_Chip-Seq_TH2_Human1.61868445
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60025588
47* PU_27001747_Chip-Seq_BMDM_Mouse1.59962371
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56607638
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54008225
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.52013950
51VDR_24787735_ChIP-Seq_THP-1_Human1.50538813
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46408261
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40012725
54GATA1_22025678_ChIP-Seq_K562_Human1.39828537
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33673539
56GATA3_26560356_Chip-Seq_TH2_Human1.32146767
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31600529
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26591202
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26027196
60KDM2B_26808549_Chip-Seq_DND41_Human1.25960943
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24647398
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23078907
63* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22749054
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21149069
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19105063
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18973666
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11411910
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11265483
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10781306
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.09698009
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08680092
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06045985
73VDR_23849224_ChIP-Seq_CD4+_Human1.05800101
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04937833
75E2F7_22180533_ChIP-Seq_HELA_Human1.03560048
76* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00595091
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00211670
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99723336
79STAT1_20625510_ChIP-Seq_HELA_Human0.96505902
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.92465563
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89092930
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88697371
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.88608483
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88426542
85GATA3_26560356_Chip-Seq_TH1_Human0.86780298
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85130860
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84256162
88* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83830899
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.81197113
90SMRT_27268052_Chip-Seq_Bcells_Human0.78630713
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77742257
92GATA2_19941826_ChIP-Seq_K562_Human0.77366931
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77082583
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.76063899
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75314044
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73908880
97SPI1_20517297_ChIP-Seq_HL60_Human0.73395462
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73391307
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72901225
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72738879
101BCL6_27268052_Chip-Seq_Bcells_Human0.72596800
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72116829
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72074627
104EGR1_19032775_ChIP-ChIP_M12_Human0.71062119
105RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70529157
106EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70091876
107GATA1_19941826_ChIP-Seq_K562_Human0.69523202
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69230387
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68709973
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67004161
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66306464
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.63419461
113P300_27268052_Chip-Seq_Bcells_Human0.62557807
114CIITA_25753668_ChIP-Seq_RAJI_Human0.61578097
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61355909
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.60739747
117SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.60167114
118TFEB_21752829_ChIP-Seq_HELA_Human0.60010388
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.59888209
120RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59205759
121NCOR1_26117541_ChIP-Seq_K562_Human0.57253325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.69715955
2MP0005671_abnormal_response_to4.20673361
3MP0000685_abnormal_immune_system3.67249915
4MP0001790_abnormal_immune_system3.45307624
5MP0005387_immune_system_phenotype3.45307624
6MP0003763_abnormal_thymus_physiology3.44953166
7* MP0001800_abnormal_humoral_immune3.44543170
8MP0005000_abnormal_immune_tolerance3.30460432
9* MP0002452_abnormal_antigen_presenting3.02363095
10MP0004510_myositis2.98500326
11* MP0002723_abnormal_immune_serum2.96864067
12MP0003436_decreased_susceptibility_to2.86325382
13MP0002148_abnormal_hypersensitivity_rea2.86171324
14* MP0002420_abnormal_adaptive_immunity2.81228599
15* MP0001819_abnormal_immune_cell2.79708759
16MP0009785_altered_susceptibility_to2.70176658
17MP0002166_altered_tumor_susceptibility2.68285954
18MP0002419_abnormal_innate_immunity2.60320532
19MP0006082_CNS_inflammation2.54102513
20MP0005025_abnormal_response_to2.52974486
21MP0002405_respiratory_system_inflammati2.42150083
22* MP0002398_abnormal_bone_marrow2.39899228
23MP0003303_peritoneal_inflammation2.37651436
24* MP0000716_abnormal_immune_system2.30284859
25MP0001853_heart_inflammation2.19989352
26MP0001873_stomach_inflammation2.17222393
27MP0002006_tumorigenesis2.07323695
28MP0003724_increased_susceptibility_to2.03846931
29MP0000689_abnormal_spleen_morphology2.01968165
30MP0009333_abnormal_splenocyte_physiolog2.00859533
31MP0005310_abnormal_salivary_gland1.98454596
32MP0010155_abnormal_intestine_physiology1.96559420
33MP0002138_abnormal_hepatobiliary_system1.92635263
34MP0002722_abnormal_immune_system1.91843204
35MP0004947_skin_inflammation1.87502413
36MP0003300_gastrointestinal_ulcer1.86842128
37MP0005464_abnormal_platelet_physiology1.84991525
38* MP0002429_abnormal_blood_cell1.84401799
39MP0001845_abnormal_inflammatory_respons1.81497442
40MP0000703_abnormal_thymus_morphology1.74922902
41MP0005058_abnormal_lysosome_morphology1.67747900
42MP0002933_joint_inflammation1.61972838
43MP0002396_abnormal_hematopoietic_system1.58749800
44MP0002254_reproductive_system_inflammat1.55793037
45MP0002009_preneoplasia1.55488788
46MP0001533_abnormal_skeleton_physiology1.50857485
47MP0003866_abnormal_defecation1.46202294
48MP0000465_gastrointestinal_hemorrhage1.40499259
49MP0008469_abnormal_protein_level1.30422008
50MP0003191_abnormal_cellular_cholesterol1.28795641
51MP0002998_abnormal_bone_remodeling1.25476790
52MP0003448_altered_tumor_morphology1.24669560
53MP0000858_altered_metastatic_potential1.22113712
54MP0004808_abnormal_hematopoietic_stem1.16141674
55MP0002277_abnormal_respiratory_mucosa1.11763506
56MP0003172_abnormal_lysosome_physiology1.11054230
57MP0003183_abnormal_peptide_metabolism1.08386285
58MP0005167_abnormal_blood-brain_barrier1.06062420
59MP0000569_abnormal_digit_pigmentation1.02849289
60MP0005174_abnormal_tail_pigmentation1.00259616
61MP0009764_decreased_sensitivity_to0.98300696
62MP0001851_eye_inflammation0.96892357
63MP0001501_abnormal_sleep_pattern0.95786496
64MP0001348_abnormal_lacrimal_gland0.94431664
65MP0008004_abnormal_stomach_pH0.92205129
66MP0000490_abnormal_crypts_of0.90895797
67MP0000343_altered_response_to0.89690096
68MP0001542_abnormal_bone_strength0.89517425
69MP0002139_abnormal_hepatobiliary_system0.89242709
70MP0001545_abnormal_hematopoietic_system0.86727146
71MP0005397_hematopoietic_system_phenotyp0.86727146
72MP0008057_abnormal_DNA_replication0.85868787
73MP0003045_fibrosis0.85182441
74MP0003646_muscle_fatigue0.82050568
75MP0000249_abnormal_blood_vessel0.81133497
76MP0003806_abnormal_nucleotide_metabolis0.81023914
77MP0003656_abnormal_erythrocyte_physiolo0.78882004
78MP0009840_abnormal_foam_cell0.78781347
79MP0002163_abnormal_gland_morphology0.78092575
80MP0008007_abnormal_cellular_replicative0.77771296
81MP0005075_abnormal_melanosome_morpholog0.75647445
82MP0005076_abnormal_cell_differentiation0.75616617
83MP0005165_increased_susceptibility_to0.75519162
84MP0002136_abnormal_kidney_physiology0.72766157
85MP0000015_abnormal_ear_pigmentation0.72284728
86MP0003453_abnormal_keratinocyte_physiol0.71934919
87MP0004381_abnormal_hair_follicle0.70619223
88MP0003828_pulmonary_edema0.70308061
89MP0006054_spinal_hemorrhage0.69509490
90MP0003091_abnormal_cell_migration0.69426173
91MP0009763_increased_sensitivity_to0.68866867
92MP0003795_abnormal_bone_structure0.67543502
93MP0000604_amyloidosis0.67246673
94MP0002877_abnormal_melanocyte_morpholog0.66381034
95MP0005390_skeleton_phenotype0.63607832
96MP0002019_abnormal_tumor_incidence0.63578291
97MP0003075_altered_response_to0.63404282
98MP0005451_abnormal_body_composition0.61394165
99MP0005164_abnormal_response_to0.60146546
100MP0009278_abnormal_bone_marrow0.59738177
101MP0005166_decreased_susceptibility_to0.59195145
102MP0010352_gastrointestinal_tract_polyps0.57513904
103MP0002928_abnormal_bile_duct0.56680359
104MP0003690_abnormal_glial_cell0.55651563
105MP0001243_abnormal_dermal_layer0.55534065
106MP0001919_abnormal_reproductive_system0.55459278
107MP0004883_abnormal_blood_vessel0.55426757
108MP0008875_abnormal_xenobiotic_pharmacok0.54122309
109MP0001663_abnormal_digestive_system0.52745363
110MP0000609_abnormal_liver_physiology0.52313256
111MP0005647_abnormal_sex_gland0.51205167
112MP0005535_abnormal_body_temperature0.51020611
113MP0001765_abnormal_ion_homeostasis0.50247591
114MP0000516_abnormal_urinary_system0.50120991
115MP0000371_diluted_coat_color0.48855375
116MP0002095_abnormal_skin_pigmentation0.48171098
117MP0001881_abnormal_mammary_gland0.46374269
118MP0008961_abnormal_basal_metabolism0.46033313
119MP0009765_abnormal_xenobiotic_induced0.45713813
120MP0003279_aneurysm0.45441974
121MP0008873_increased_physiological_sensi0.45137766

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.04029021
2Myositis (HP:0100614)4.99222492
3Eczematoid dermatitis (HP:0000976)4.86568693
4Retrobulbar optic neuritis (HP:0100654)4.86015296
5Optic neuritis (HP:0100653)4.86015296
6Elevated erythrocyte sedimentation rate (HP:0003565)4.65279888
7Recurrent fungal infections (HP:0002841)4.52762340
8Abnormality of T cell number (HP:0011839)4.50253988
9Recurrent bacterial skin infections (HP:0005406)4.49272510
10T lymphocytopenia (HP:0005403)4.43434509
11Orchitis (HP:0100796)4.40421219
12Stomatitis (HP:0010280)4.38839072
13Recurrent viral infections (HP:0004429)4.26855257
14IgM deficiency (HP:0002850)4.06912274
15Agammaglobulinemia (HP:0004432)4.00619124
16Chronic mucocutaneous candidiasis (HP:0002728)3.94405395
17Recurrent cutaneous fungal infections (HP:0011370)3.94405395
18Severe combined immunodeficiency (HP:0004430)3.93691693
19Pulmonary infiltrates (HP:0002113)3.93634140
20Recurrent bronchitis (HP:0002837)3.93144440
21Thyroiditis (HP:0100646)3.88334258
22Mediastinal lymphadenopathy (HP:0100721)3.84382479
23Panhypogammaglobulinemia (HP:0003139)3.81330245
24Chronic otitis media (HP:0000389)3.75844464
25Vasculitis (HP:0002633)3.70624700
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.66235988
27Combined immunodeficiency (HP:0005387)3.60842235
28Chronic diarrhea (HP:0002028)3.55603110
29Recurrent skin infections (HP:0001581)3.55428962
30Abnormality of T cells (HP:0002843)3.54971432
31Meningitis (HP:0001287)3.47933398
32Abnormality of eosinophils (HP:0001879)3.42395939
33Colitis (HP:0002583)3.35979863
34Systemic lupus erythematosus (HP:0002725)3.35117278
35Keratoconjunctivitis sicca (HP:0001097)3.31358073
36IgG deficiency (HP:0004315)3.30523144
37Inflammation of the large intestine (HP:0002037)3.26502693
38Leukocytosis (HP:0001974)3.26457761
39Arterial thrombosis (HP:0004420)3.24007054
40Chronic obstructive pulmonary disease (HP:0006510)3.15508809
41Obstructive lung disease (HP:0006536)3.15508809
42Eosinophilia (HP:0001880)3.14055536
43Spontaneous hematomas (HP:0007420)3.08918752
44Gastrointestinal inflammation (HP:0004386)3.05790376
45Increased IgM level (HP:0003496)3.04452047
46Keratoconjunctivitis (HP:0001096)3.04132260
47Hemoptysis (HP:0002105)3.02027580
48Encephalitis (HP:0002383)2.93883298
49Gastrointestinal stroma tumor (HP:0100723)2.88218579
50Nasal polyposis (HP:0100582)2.85904897
51Lymphopenia (HP:0001888)2.84906347
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.79750964
53Recurrent sinusitis (HP:0011108)2.79738562
54Abnormality of T cell physiology (HP:0011840)2.78189901
55Autoimmune thrombocytopenia (HP:0001973)2.77994526
56Gastrointestinal infarctions (HP:0005244)2.75962728
57Amyloidosis (HP:0011034)2.74819368
58Granulocytopenia (HP:0001913)2.74717470
59B lymphocytopenia (HP:0010976)2.73941239
60Abnormality of B cell number (HP:0010975)2.73941239
61IgA deficiency (HP:0002720)2.73396960
62Pustule (HP:0200039)2.72626813
63Polyneuropathy (HP:0001271)2.68263774
64Thrombocytosis (HP:0001894)2.68216080
65Urticaria (HP:0001025)2.67818146
66Gingivitis (HP:0000230)2.67734759
67Abnormality of the pleura (HP:0002103)2.64855280
68Abnormality of the prostate (HP:0008775)2.63048509
69Cellulitis (HP:0100658)2.61166008
70Increased IgE level (HP:0003212)2.55244125
71Glomerulonephritis (HP:0000099)2.53595708
72Abnormality of macrophages (HP:0004311)2.52379856
73Abnormality of the nasal mucosa (HP:0000433)2.49038143
74Recurrent gram-negative bacterial infections (HP:0005420)2.46712603
75Abnormality of the fingertips (HP:0001211)2.45559933
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.45334606
77Osteomyelitis (HP:0002754)2.44495890
78Increased density of long bones (HP:0006392)2.44423007
79Periodontitis (HP:0000704)2.43784911
80Hypergammaglobulinemia (HP:0010702)2.40194916
81Prostate neoplasm (HP:0100787)2.38818685
82Alveolar cell carcinoma (HP:0006519)2.37993559
83Chest pain (HP:0100749)2.36369013
84Increased serum ferritin (HP:0003281)2.35302286
85Pulmonary fibrosis (HP:0002206)2.33425737
86Petechiae (HP:0000967)2.33384887
87Anorexia (HP:0002039)2.32668468
88Glomerulopathy (HP:0100820)2.32343420
89Increased cerebral lipofuscin (HP:0011813)2.32087544
90Joint swelling (HP:0001386)2.31448050
91Pulmonary embolism (HP:0002204)2.31389625
92Interstitial pulmonary disease (HP:0006530)2.30449276
93Persistence of primary teeth (HP:0006335)2.29788915
94Vacuolated lymphocytes (HP:0001922)2.26624066
95Hematochezia (HP:0002573)2.24114137
96Emphysema (HP:0002097)2.23511402
97Fatigue (HP:0012378)2.23448500
98Lymphoma (HP:0002665)2.23255784
99Hypoplasia of the thymus (HP:0000778)2.22310794
100Restrictive lung disease (HP:0002091)2.21711935
101Amaurosis fugax (HP:0100576)2.21577331
102Gingival bleeding (HP:0000225)2.20208137
103Stomach cancer (HP:0012126)2.19062912
104Epistaxis (HP:0000421)2.18758977
105Myocardial infarction (HP:0001658)2.18493499
106Vertigo (HP:0002321)2.17311958
107Abnormality of liposaccharide metabolism (HP:0010968)2.17182950
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.17182950
109Abnormality of glycolipid metabolism (HP:0010969)2.17182950
110Arthralgia (HP:0002829)2.16770793
111Loss of speech (HP:0002371)2.16010675
112Gangrene (HP:0100758)2.15368654
113Verrucae (HP:0200043)2.14908693
114Papilloma (HP:0012740)2.14908693
115Neoplasm of the tracheobronchial system (HP:0100552)2.14365624
116Basal ganglia calcification (HP:0002135)2.13830109
117Dysostosis multiplex (HP:0000943)2.12690864
118Autoimmune hemolytic anemia (HP:0001890)2.12097047
119Disinhibition (HP:0000734)2.11814542
120Keratitis (HP:0000491)2.06504062
121Thrombophlebitis (HP:0004418)2.03242475
122Abnormality of iron homeostasis (HP:0011031)2.02166154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.96239873
2MAP4K14.75032574
3MAP3K144.20316511
4TYK23.01330156
5TGFBR22.74075616
6BLK2.62674449
7JAK32.56196334
8IKBKE2.53306446
9TBK12.52797777
10IKBKB2.51900044
11ITK2.49236751
12IRAK32.48543862
13CDK192.41870451
14JAK12.41477925
15IRAK42.37276460
16MAP3K132.29285406
17ZAP702.14103375
18MAP3K122.05473244
19STK102.03693215
20TEC1.89176619
21CHUK1.83366669
22TAOK31.81008537
23CSF1R1.74148573
24BTK1.73598089
25GRK61.69554430
26SYK1.66542591
27KIT1.65395009
28FGFR41.57037073
29LCK1.56423324
30TLK11.54404754
31MAP2K21.52116024
32CSK1.44699989
33HCK1.40179336
34EPHB11.39128804
35NLK1.37349411
36FGFR31.32095926
37RIPK41.25168896
38TRPM71.22979779
39MST41.18616732
40PIM11.15347779
41TSSK61.14877994
42TAOK21.11050313
43LYN1.09163687
44CLK11.07827665
45MAP3K101.06294688
46EPHA31.05869716
47MAPK151.01982506
48ERBB30.99015705
49GRK70.98803351
50JAK20.96735897
51RPS6KA40.94779438
52NEK90.94267676
53PRKCQ0.88007787
54SIK20.87609454
55BCKDK0.86584976
56PIK3CG0.86010911
57FES0.85345315
58LRRK20.77123628
59CAMKK20.76212220
60MARK30.75804549
61MYLK0.72355086
62IRAK10.71339671
63MAP3K30.68882137
64ARAF0.67411299
65SIK30.67037582
66PIM20.64742517
67MAP4K20.64583648
68PKN10.62618919
69CAMKK10.59310513
70OXSR10.58768223
71MAPKAPK20.58662785
72CDK120.57549617
73PASK0.55754810
74MAPK120.55620895
75MAP2K30.54472225
76PRPF4B0.54128648
77TESK20.49969359
78RPS6KA50.49423389
79EIF2AK20.48624670
80EEF2K0.48595551
81MAP3K10.47206621
82KDR0.46983884
83CDK90.46557681
84MELK0.45660683
85BMPR20.45358194
86HIPK20.45333889
87MAPK70.45212839
88FGR0.43611733
89IGF1R0.43250467
90TGFBR10.43024181
91INSR0.41652637
92PRKCD0.39892215
93PDK10.38158081
94RPS6KA60.37342703
95MATK0.36668021
96MAP3K110.36312737
97RPS6KL10.35463806
98RPS6KC10.35463806
99PDGFRB0.35364507
100ERN10.34884601
101CDK60.34649287
102ABL10.34459845
103PTK60.34254217
104MAPK110.33800593
105FLT30.32982695
106NUAK10.32593919
107DAPK30.32292374
108TNK20.30681032
109STK240.30550428
110EGFR0.30174236
111CDK40.30130980
112FYN0.29562761
113MAP3K50.29441502
114NME20.29142897
115EIF2AK30.27787528
116VRK10.26201680
117MOS0.26165716
118IRAK20.25315100
119GSK3A0.25060735
120ADRBK20.24733848
121MAP2K60.23514183
122ABL20.22946587
123PRKAA20.22479676
124MAPK30.21717908
125STK40.21708462
126ILK0.20417337
127MAP3K70.19699464
128RPS6KA10.19046041
129BRD40.18768429
130MAPK40.18550776
131CAMK1D0.18202051

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.86064256
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.19851904
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.00468459
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.91712416
5Osteoclast differentiation_Homo sapiens_hsa043802.81754975
6Allograft rejection_Homo sapiens_hsa053302.80721279
7Leishmaniasis_Homo sapiens_hsa051402.65427623
8B cell receptor signaling pathway_Homo sapiens_hsa046622.61331571
9Measles_Homo sapiens_hsa051622.58774353
10Antigen processing and presentation_Homo sapiens_hsa046122.58129822
11T cell receptor signaling pathway_Homo sapiens_hsa046602.53592879
12Graft-versus-host disease_Homo sapiens_hsa053322.48509904
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.24566535
14Autoimmune thyroid disease_Homo sapiens_hsa053202.12444006
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93994404
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93174652
17Staphylococcus aureus infection_Homo sapiens_hsa051501.90610046
18Hematopoietic cell lineage_Homo sapiens_hsa046401.79545240
19Toxoplasmosis_Homo sapiens_hsa051451.74330126
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.72213750
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72118344
22Chemokine signaling pathway_Homo sapiens_hsa040621.59746519
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58714709
24TNF signaling pathway_Homo sapiens_hsa046681.56469381
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55203711
26Herpes simplex infection_Homo sapiens_hsa051681.54499959
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47485336
28Viral myocarditis_Homo sapiens_hsa054161.46518209
29Apoptosis_Homo sapiens_hsa042101.43735243
30Other glycan degradation_Homo sapiens_hsa005111.42453460
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41724437
32Legionellosis_Homo sapiens_hsa051341.40132371
33Influenza A_Homo sapiens_hsa051641.39162982
34Pertussis_Homo sapiens_hsa051331.36634879
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34623571
36Tuberculosis_Homo sapiens_hsa051521.33941237
37Asthma_Homo sapiens_hsa053101.26596614
38Hepatitis B_Homo sapiens_hsa051611.23461978
39Shigellosis_Homo sapiens_hsa051311.19753409
40Malaria_Homo sapiens_hsa051441.18801285
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16911841
42Acute myeloid leukemia_Homo sapiens_hsa052211.14246798
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.10762919
44Type I diabetes mellitus_Homo sapiens_hsa049401.09004416
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03388728
46Lysosome_Homo sapiens_hsa041420.98671310
47Rheumatoid arthritis_Homo sapiens_hsa053230.97481369
48Salmonella infection_Homo sapiens_hsa051320.96590155
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.95012702
50Chronic myeloid leukemia_Homo sapiens_hsa052200.94337921
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93946813
52Pancreatic cancer_Homo sapiens_hsa052120.93597386
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85431653
54Prolactin signaling pathway_Homo sapiens_hsa049170.85219975
55HTLV-I infection_Homo sapiens_hsa051660.82901201
56Platelet activation_Homo sapiens_hsa046110.82196580
57Hepatitis C_Homo sapiens_hsa051600.81553256
58Viral carcinogenesis_Homo sapiens_hsa052030.74483370
59Small cell lung cancer_Homo sapiens_hsa052220.72230211
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.68526809
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68061291
62African trypanosomiasis_Homo sapiens_hsa051430.67861809
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64260748
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60543584
65Endocytosis_Homo sapiens_hsa041440.59890052
66MAPK signaling pathway_Homo sapiens_hsa040100.56679385
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56669753
68Colorectal cancer_Homo sapiens_hsa052100.51362794
69p53 signaling pathway_Homo sapiens_hsa041150.50515580
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48850604
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46435354
72VEGF signaling pathway_Homo sapiens_hsa043700.45833423
73FoxO signaling pathway_Homo sapiens_hsa040680.41488858
74Non-homologous end-joining_Homo sapiens_hsa034500.41387960
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39954394
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37994736
77Regulation of autophagy_Homo sapiens_hsa041400.37886898
78Non-small cell lung cancer_Homo sapiens_hsa052230.37484077
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37467156
80Notch signaling pathway_Homo sapiens_hsa043300.37385341
81Collecting duct acid secretion_Homo sapiens_hsa049660.36612294
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.33644388
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33436257
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.33388455
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32801554
86Oxidative phosphorylation_Homo sapiens_hsa001900.31907029
87Phagosome_Homo sapiens_hsa041450.31750792
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28709170
89Arachidonic acid metabolism_Homo sapiens_hsa005900.27957866
90Prostate cancer_Homo sapiens_hsa052150.26499065
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26437758
92HIF-1 signaling pathway_Homo sapiens_hsa040660.25846300
93Inositol phosphate metabolism_Homo sapiens_hsa005620.25072871
94Renal cell carcinoma_Homo sapiens_hsa052110.24782457
95Insulin resistance_Homo sapiens_hsa049310.23701336
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23534226
97Ribosome_Homo sapiens_hsa030100.23217923
98Pathways in cancer_Homo sapiens_hsa052000.22878723
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22055650
100Systemic lupus erythematosus_Homo sapiens_hsa053220.21766512
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21217997
102MicroRNAs in cancer_Homo sapiens_hsa052060.20800915
103Prion diseases_Homo sapiens_hsa050200.20756899
104Linoleic acid metabolism_Homo sapiens_hsa005910.18183542
105Type II diabetes mellitus_Homo sapiens_hsa049300.17496670
106Adherens junction_Homo sapiens_hsa045200.16304024
107Amoebiasis_Homo sapiens_hsa051460.15940185
108Bladder cancer_Homo sapiens_hsa052190.15491238
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.13919407
110ABC transporters_Homo sapiens_hsa020100.12358822
111Proteasome_Homo sapiens_hsa030500.12194998
112Base excision repair_Homo sapiens_hsa034100.10904389
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09658514
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08376193
115Ether lipid metabolism_Homo sapiens_hsa005650.06083596
116Parkinsons disease_Homo sapiens_hsa050120.04650861
117Complement and coagulation cascades_Homo sapiens_hsa046100.00456555
118Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0618826
119Chemical carcinogenesis_Homo sapiens_hsa05204-0.0546388
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0484787
121RNA degradation_Homo sapiens_hsa03018-0.0259786
122Sphingolipid metabolism_Homo sapiens_hsa00600-0.0169212
123Renin-angiotensin system_Homo sapiens_hsa04614-0.0119369
124Tryptophan metabolism_Homo sapiens_hsa00380-0.0115112
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0060761
126Alzheimers disease_Homo sapiens_hsa05010-0.0005292

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