GPR19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.29269244
2transcription from mitochondrial promoter (GO:0006390)7.95173530
3replication fork processing (GO:0031297)7.44323520
4embryonic process involved in female pregnancy (GO:0060136)6.93564163
5oxidative demethylation (GO:0070989)6.42459366
6positive regulation of protein homooligomerization (GO:0032464)6.36112924
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.06208699
8regulation of protein homooligomerization (GO:0032462)5.94766853
9DNA deamination (GO:0045006)5.87301195
10establishment of apical/basal cell polarity (GO:0035089)5.74742720
11DNA strand renaturation (GO:0000733)5.58468778
12regulation of integrin activation (GO:0033623)5.30619039
13poly(A)+ mRNA export from nucleus (GO:0016973)5.25560781
14establishment or maintenance of monopolar cell polarity (GO:0061339)5.14696497
15establishment of monopolar cell polarity (GO:0061162)5.14696497
16somatic hypermutation of immunoglobulin genes (GO:0016446)5.11602632
17somatic diversification of immune receptors via somatic mutation (GO:0002566)5.11602632
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.97704951
19negative regulation of JAK-STAT cascade (GO:0046426)4.96923455
20viral mRNA export from host cell nucleus (GO:0046784)4.94976007
21mitochondrial DNA metabolic process (GO:0032042)4.80875967
22negative regulation of protein oligomerization (GO:0032460)4.63524848
23cellular response to ATP (GO:0071318)4.39220858
24DNA integration (GO:0015074)4.38672245
25glutamine family amino acid biosynthetic process (GO:0009084)4.36127545
26negative regulation of cell cycle arrest (GO:0071157)4.36089896
27positive regulation of developmental pigmentation (GO:0048087)4.33275626
28negative regulation of Ras GTPase activity (GO:0034261)4.19770751
29spliceosomal tri-snRNP complex assembly (GO:0000244)4.12833681
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.08761285
31mRNA cleavage (GO:0006379)4.07285009
32embryonic placenta development (GO:0001892)4.02960889
33regulation of translational fidelity (GO:0006450)4.02119721
34mitotic G1 DNA damage checkpoint (GO:0031571)3.97855877
35convergent extension (GO:0060026)3.93421067
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87411369
37base-excision repair, AP site formation (GO:0006285)3.86827248
38base-excision repair (GO:0006284)3.85949955
39DNA double-strand break processing (GO:0000729)3.85635798
40telomere maintenance via semi-conservative replication (GO:0032201)3.84408336
41regulation of cAMP-dependent protein kinase activity (GO:2000479)3.79503790
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.79268004
43non-recombinational repair (GO:0000726)3.78041931
44double-strand break repair via nonhomologous end joining (GO:0006303)3.78041931
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76306121
46mitotic G1/S transition checkpoint (GO:0044819)3.72703713
47pyrimidine nucleobase catabolic process (GO:0006208)3.71524339
48negative regulation of heart rate (GO:0010459)3.67900016
49chromatin remodeling at centromere (GO:0031055)3.67697588
50glial cell migration (GO:0008347)3.67322855
51positive regulation of DNA repair (GO:0045739)3.65454018
52G1 DNA damage checkpoint (GO:0044783)3.65437446
53regulation of sister chromatid cohesion (GO:0007063)3.65268198
54regulation of protein oligomerization (GO:0032459)3.63338580
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.59864382
56auditory receptor cell stereocilium organization (GO:0060088)3.59550301
57regulation of timing of cell differentiation (GO:0048505)3.57771236
58maturation of 5.8S rRNA (GO:0000460)3.56760789
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.56608491
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.56608491
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.56608491
62positive regulation by host of viral transcription (GO:0043923)3.56207744
63regulation of development, heterochronic (GO:0040034)3.55269468
64DNA ligation (GO:0006266)3.53503775
65histone H4-K12 acetylation (GO:0043983)3.52679573
66negative regulation of mRNA processing (GO:0050686)3.49259511
67mitochondrial RNA metabolic process (GO:0000959)3.48786941
68embryonic camera-type eye development (GO:0031076)3.48482237
69negative regulation of fatty acid biosynthetic process (GO:0045717)3.44946784
70synaptic vesicle endocytosis (GO:0048488)3.44240241
71CENP-A containing nucleosome assembly (GO:0034080)3.43099636
72DNA demethylation (GO:0080111)3.41417897
73GDP-mannose metabolic process (GO:0019673)3.40611656
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38520121
75N-glycan processing (GO:0006491)3.38249458
76face development (GO:0060324)3.37301792
77positive regulation of mitochondrial fission (GO:0090141)3.37181522
78termination of RNA polymerase II transcription (GO:0006369)3.37117551
79labyrinthine layer development (GO:0060711)3.35862400
80histone arginine methylation (GO:0034969)3.29933057
81negative regulation of response to food (GO:0032096)3.28163409
82negative regulation of appetite (GO:0032099)3.28163409
83positive regulation of protein oligomerization (GO:0032461)3.27238627
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26587005
85cell migration in hindbrain (GO:0021535)3.25214915
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22452715
87presynaptic membrane assembly (GO:0097105)3.21170088
88DNA damage response, detection of DNA damage (GO:0042769)3.20185577
89meiotic chromosome segregation (GO:0045132)3.19957724
90formation of translation preinitiation complex (GO:0001731)3.19236497
91epithelial cilium movement (GO:0003351)3.16388920
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13355457
93regulation of mitochondrial depolarization (GO:0051900)3.13331878
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.12080833
95activation of Rac GTPase activity (GO:0032863)3.11976743
96regulation of double-strand break repair via homologous recombination (GO:0010569)3.11108371
97secondary metabolite biosynthetic process (GO:0044550)3.09967988
98mRNA polyadenylation (GO:0006378)3.09765476
99regulation of double-strand break repair (GO:2000779)3.09167607
100cullin deneddylation (GO:0010388)3.07622570
101telomere maintenance via recombination (GO:0000722)3.07211823
102melanin biosynthetic process (GO:0042438)3.07125817
103sequestering of actin monomers (GO:0042989)3.07111878
104pyrimidine nucleotide catabolic process (GO:0006244)3.06917211
105regulation of respiratory system process (GO:0044065)3.04589340
106protein K6-linked ubiquitination (GO:0085020)3.02708733
107kinetochore assembly (GO:0051382)3.02316854
108regulation of cilium movement (GO:0003352)3.01747560
109histone exchange (GO:0043486)3.00134586
110spinal cord development (GO:0021510)2.98947771
111presynaptic membrane organization (GO:0097090)2.98867243
112DNA topological change (GO:0006265)2.96702239
113DNA replication-independent nucleosome organization (GO:0034724)2.96670211
114DNA replication-independent nucleosome assembly (GO:0006336)2.96670211
115limb bud formation (GO:0060174)2.96667224
116nuclear envelope reassembly (GO:0031468)2.95432427
117mitotic nuclear envelope reassembly (GO:0007084)2.95432427
118cellular response to zinc ion (GO:0071294)2.95162998
119behavioral response to nicotine (GO:0035095)2.95136120
120dosage compensation (GO:0007549)2.94240887
121regulation of DNA damage checkpoint (GO:2000001)2.94195755
122somite development (GO:0061053)2.87797162
123protein neddylation (GO:0045116)2.85980509
124olfactory bulb development (GO:0021772)2.83615071
125mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81245688
126energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80397480
127ATP synthesis coupled proton transport (GO:0015986)2.80397480
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79140678
129mitochondrial respiratory chain complex I assembly (GO:0032981)2.79140678
130NADH dehydrogenase complex assembly (GO:0010257)2.79140678
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.78399557
132sympathetic nervous system development (GO:0048485)2.77900800
133nucleobase catabolic process (GO:0046113)2.75157905
134chaperone-mediated protein transport (GO:0072321)2.74068723
135postsynaptic membrane organization (GO:0001941)2.72763448
136L-serine metabolic process (GO:0006563)2.72131680
137mitochondrial respiratory chain complex assembly (GO:0033108)2.68585015
138neuron cell-cell adhesion (GO:0007158)2.68012635
139forebrain neuron differentiation (GO:0021879)2.67374412
140peptidyl-arginine omega-N-methylation (GO:0035247)2.66918543
141protein localization to synapse (GO:0035418)2.65726559
142melanin metabolic process (GO:0006582)2.63497326
143regulation of mitotic spindle checkpoint (GO:1903504)2.63463542
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63463542
145protein complex biogenesis (GO:0070271)2.60919406
146proteasome assembly (GO:0043248)2.57421879
147recombinational repair (GO:0000725)2.52527285
148peptidyl-arginine methylation (GO:0018216)2.50644027
149peptidyl-arginine N-methylation (GO:0035246)2.50644027
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50589959
151kinetochore organization (GO:0051383)2.50251374
152double-strand break repair via homologous recombination (GO:0000724)2.49240691
153regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.47895726
154retinal ganglion cell axon guidance (GO:0031290)2.46682776
155axonal fasciculation (GO:0007413)2.46126922
156protein-cofactor linkage (GO:0018065)2.45826485
157short-term memory (GO:0007614)2.41065237
158reciprocal meiotic recombination (GO:0007131)2.40872221
159reciprocal DNA recombination (GO:0035825)2.40872221
160DNA replication-dependent nucleosome organization (GO:0034723)2.40499660
161DNA replication-dependent nucleosome assembly (GO:0006335)2.40499660
162neuron fate determination (GO:0048664)2.40165514
163lung-associated mesenchyme development (GO:0060484)2.38114985
164vocalization behavior (GO:0071625)2.37028836
165establishment of integrated proviral latency (GO:0075713)2.36819644
166intraciliary transport (GO:0042073)2.36809370
167nonmotile primary cilium assembly (GO:0035058)2.36783689
168resolution of meiotic recombination intermediates (GO:0000712)2.36174246
169cerebral cortex radially oriented cell migration (GO:0021799)2.34696144
170respiratory electron transport chain (GO:0022904)2.34192313
171RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.33359566
172histone H2A acetylation (GO:0043968)2.32759730
173negative regulation of oligodendrocyte differentiation (GO:0048715)2.32431326
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31474310
175C4-dicarboxylate transport (GO:0015740)2.30774488
176regulation of helicase activity (GO:0051095)2.30737577
177spermatid development (GO:0007286)2.30666120
178negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.30426500
179negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.30426500
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.30426500
181negative regulation of mitotic sister chromatid separation (GO:2000816)2.30426500
182negative regulation of sister chromatid segregation (GO:0033046)2.30426500
183regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29327964
184neural tube formation (GO:0001841)2.29264796
185electron transport chain (GO:0022900)2.29021217
186respiratory chain complex IV assembly (GO:0008535)2.28201813
187negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.27458220
188proline biosynthetic process (GO:0006561)10.6056860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.84275865
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.65500690
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.65500690
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.65500690
5* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.37921837
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23340734
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.19556607
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12761956
9* SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.09296423
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07388660
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.95567668
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.80820453
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.78498933
14POU5F1_16518401_ChIP-PET_MESCs_Mouse2.70358326
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64430607
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.62334561
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60433966
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59240796
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58738663
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55885212
21ZNF274_21170338_ChIP-Seq_K562_Hela2.55457919
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.51938084
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.46225946
24EZH2_22144423_ChIP-Seq_EOC_Human2.27950705
25VDR_22108803_ChIP-Seq_LS180_Human2.19232985
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.17297695
27ELK1_19687146_ChIP-ChIP_HELA_Human2.16595313
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15140768
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.11831903
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.11136511
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10640655
32FUS_26573619_Chip-Seq_HEK293_Human2.06884886
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05979937
34IGF1R_20145208_ChIP-Seq_DFB_Human2.04247574
35* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02848465
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01202045
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.00361248
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99466915
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98382787
40GBX2_23144817_ChIP-Seq_PC3_Human1.98274756
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.97395510
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95535940
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93664156
44EWS_26573619_Chip-Seq_HEK293_Human1.93592544
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93086364
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87202614
47* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.86482845
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86462182
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85439043
50MYC_18940864_ChIP-ChIP_HL60_Human1.85384341
51VDR_21846776_ChIP-Seq_THP-1_Human1.82931251
52LXR_22292898_ChIP-Seq_THP-1_Human1.82404767
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81931035
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79495015
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77858508
56PU.1_20513432_ChIP-Seq_Bcells_Mouse1.76736188
57* NANOG_21062744_ChIP-ChIP_HESCs_Human1.75889331
58P300_19829295_ChIP-Seq_ESCs_Human1.74090795
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73063092
60* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70855189
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.68129473
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64119461
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.63769881
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60379033
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.60330303
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.59709702
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.59537618
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.57711239
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57710050
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55838931
71* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.55485725
72* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49620502
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48936907
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48936907
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.48931857
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48453247
77* VDR_23849224_ChIP-Seq_CD4+_Human1.48166081
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47897669
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47690318
80* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45628971
81TAF15_26573619_Chip-Seq_HEK293_Human1.45617803
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45087583
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.43354633
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42322994
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41932802
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41876957
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40675794
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40223632
89* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.39472225
90FOXP3_21729870_ChIP-Seq_TREG_Human1.39067065
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.38401125
92* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37097513
93RNF2_27304074_Chip-Seq_NSC_Mouse1.36612322
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36107039
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35726422
96* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35718780
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35212585
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32818147
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.30915592
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30806965
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30321326
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29323667
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29228642
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.29064223
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29032446
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28521597
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27950535
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27776073
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26794226
110NANOG_16518401_ChIP-PET_MESCs_Mouse1.24848213
111* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23316750
112RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22466548
113* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22139976
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.21799600
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21336349
116EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20124435
117* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19262290
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19004211
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18538764
120* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17001155
121ETS1_21867929_ChIP-Seq_TH2_Mouse1.16837013
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15829374
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15405272
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15181389
125E2F1_21310950_ChIP-Seq_MCF-7_Human1.14755881
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13008581
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12725272
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.12620707
129TTF2_22483619_ChIP-Seq_HELA_Human1.12389244
130KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12294789
131SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11695403
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.11550451
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.11502915
134IRF1_19129219_ChIP-ChIP_H3396_Human1.11269836
135* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10837002
136* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10471923
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09471629
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09324395
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09247817
140* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09236451
141E2F7_22180533_ChIP-Seq_HELA_Human1.08482186
142YY1_22570637_ChIP-Seq_MALME-3M_Human1.08314851
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07999198
144REST_21632747_ChIP-Seq_MESCs_Mouse1.07931389
145* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06623846
146* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06255201
147STAT1_20625510_ChIP-Seq_HELA_Human1.05062433
148SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04680365
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04108565
150GABP_19822575_ChIP-Seq_HepG2_Human1.03331549
151* SMAD3_21741376_ChIP-Seq_EPCs_Human1.02767949
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02644016
153KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02391932
154ETS1_20019798_ChIP-Seq_JURKAT_Human1.01134091
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00952384
156* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00799419
157PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00332154
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00127894
159SMAD4_21799915_ChIP-Seq_A2780_Human1.00012569
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99811182
161RARA_24833708_ChIP-Seq_LIVER_Mouse0.99001072
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98991882
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98558764
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98437264
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97271600
166CTCF_27219007_Chip-Seq_Bcells_Human0.97083215
167KAP1_27257070_Chip-Seq_ESCs_Mouse0.97049214
168* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96982118
169* RACK7_27058665_Chip-Seq_MCF-7_Human0.96308538
170PIAS1_25552417_ChIP-Seq_VCAP_Human0.96251221
171CBP_20019798_ChIP-Seq_JUKART_Human0.95986348
172IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95986348
173TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95468727
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95071770
175* TET1_21490601_ChIP-Seq_MESCs_Mouse0.94934469
176TP53_22573176_ChIP-Seq_HFKS_Human0.94537731
177* JUN_21703547_ChIP-Seq_K562_Human0.92426999
178PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92037387
179ER_23166858_ChIP-Seq_MCF-7_Human0.91325141
180TP63_19390658_ChIP-ChIP_HaCaT_Human0.88946768
181RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88637721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.57868868
2MP0005171_absent_coat_pigmentation5.33789455
3MP0002102_abnormal_ear_morphology3.78616733
4MP0010030_abnormal_orbit_morphology3.78487013
5MP0002009_preneoplasia3.26146174
6MP0004233_abnormal_muscle_weight3.25249289
7MP0009278_abnormal_bone_marrow3.22751774
8MP0002653_abnormal_ependyma_morphology2.94466982
9MP0006072_abnormal_retinal_apoptosis2.83805393
10MP0000372_irregular_coat_pigmentation2.70206315
11MP0008877_abnormal_DNA_methylation2.54448075
12MP0004133_heterotaxia2.53775489
13MP0003283_abnormal_digestive_organ2.52410676
14MP0008995_early_reproductive_senescence2.46642790
15MP0003880_abnormal_central_pattern2.44431164
16MP0003890_abnormal_embryonic-extraembry2.43012356
17MP0003122_maternal_imprinting2.37174770
18MP0003787_abnormal_imprinting2.32179933
19MP0001529_abnormal_vocalization2.20831502
20MP0003121_genomic_imprinting2.17574788
21MP0002249_abnormal_larynx_morphology2.11539965
22MP0008789_abnormal_olfactory_epithelium2.10857749
23MP0000566_synostosis2.02879091
24MP0003136_yellow_coat_color2.00435633
25MP0003119_abnormal_digestive_system1.93560905
26MP0005174_abnormal_tail_pigmentation1.91825472
27MP0010094_abnormal_chromosome_stability1.88707119
28MP0005394_taste/olfaction_phenotype1.82784671
29MP0005499_abnormal_olfactory_system1.82784671
30MP0005645_abnormal_hypothalamus_physiol1.74025383
31MP0000015_abnormal_ear_pigmentation1.71505221
32MP0002282_abnormal_trachea_morphology1.69114968
33MP0006292_abnormal_olfactory_placode1.65657189
34MP0000579_abnormal_nail_morphology1.64978275
35MP0003693_abnormal_embryo_hatching1.64074634
36MP0004142_abnormal_muscle_tone1.61729091
37MP0000631_abnormal_neuroendocrine_gland1.61690542
38MP0003786_premature_aging1.59385204
39MP0009046_muscle_twitch1.59324911
40MP0005377_hearing/vestibular/ear_phenot1.55065501
41MP0003878_abnormal_ear_physiology1.55065501
42MP0005423_abnormal_somatic_nervous1.51481922
43MP0000462_abnormal_digestive_system1.49116948
44MP0002234_abnormal_pharynx_morphology1.48945905
45MP0001984_abnormal_olfaction1.48477632
46MP0001293_anophthalmia1.43016098
47MP0008058_abnormal_DNA_repair1.40934892
48MP0006276_abnormal_autonomic_nervous1.38463256
49MP0002272_abnormal_nervous_system1.37859890
50MP0001486_abnormal_startle_reflex1.37072538
51MP0008932_abnormal_embryonic_tissue1.33315977
52MP0003937_abnormal_limbs/digits/tail_de1.33258996
53MP0005075_abnormal_melanosome_morpholog1.32887494
54MP0002233_abnormal_nose_morphology1.32878585
55MP0003172_abnormal_lysosome_physiology1.31534060
56MP0002736_abnormal_nociception_after1.30133309
57MP0005253_abnormal_eye_physiology1.28859159
58MP0004957_abnormal_blastocyst_morpholog1.27776786
59MP0002084_abnormal_developmental_patter1.27548470
60MP0001340_abnormal_eyelid_morphology1.24347138
61MP0000639_abnormal_adrenal_gland1.22892638
62MP0009745_abnormal_behavioral_response1.22260314
63MP0001968_abnormal_touch/_nociception1.20882584
64MP0000778_abnormal_nervous_system1.19906522
65MP0002095_abnormal_skin_pigmentation1.17881069
66* MP0002572_abnormal_emotion/affect_behav1.16745899
67MP0002085_abnormal_embryonic_tissue1.16541576
68MP0005397_hematopoietic_system_phenotyp1.14935264
69MP0001545_abnormal_hematopoietic_system1.14935264
70MP0005551_abnormal_eye_electrophysiolog1.14514491
71MP0003755_abnormal_palate_morphology1.14404891
72MP0002063_abnormal_learning/memory/cond1.12354821
73MP0002733_abnormal_thermal_nociception1.10760826
74MP0003137_abnormal_impulse_conducting1.10235244
75MP0002697_abnormal_eye_size1.09907827
76MP0000955_abnormal_spinal_cord1.09766473
77MP0001697_abnormal_embryo_size1.08647937
78MP0000049_abnormal_middle_ear1.08401807
79MP0002638_abnormal_pupillary_reflex1.08398224
80MP0002064_seizures1.07714134
81MP0002086_abnormal_extraembryonic_tissu1.05940833
82MP0001286_abnormal_eye_development1.05800557
83MP0002735_abnormal_chemical_nociception1.05774777
84MP0000762_abnormal_tongue_morphology1.05659075
85MP0003938_abnormal_ear_development1.05120035
86MP0005248_abnormal_Harderian_gland1.05021714
87MP0004924_abnormal_behavior1.04765636
88MP0005386_behavior/neurological_phenoty1.04765636
89MP0002751_abnormal_autonomic_nervous1.02576629
90MP0003221_abnormal_cardiomyocyte_apopto1.02122279
91MP0004197_abnormal_fetal_growth/weight/1.01868315
92MP0001299_abnormal_eye_distance/1.01564292
93MP0002752_abnormal_somatic_nervous1.01367966
94MP0002111_abnormal_tail_morphology1.01213265
95MP0001502_abnormal_circadian_rhythm1.00357336
96MP0000026_abnormal_inner_ear0.99023266
97MP0002269_muscular_atrophy0.98969805
98MP0004742_abnormal_vestibular_system0.98905852
99MP0001188_hyperpigmentation0.98454100
100MP0003453_abnormal_keratinocyte_physiol0.98082980
101MP0002116_abnormal_craniofacial_bone0.98080695
102MP0004885_abnormal_endolymph0.97309256
103MP0002114_abnormal_axial_skeleton0.95836497
104MP0002075_abnormal_coat/hair_pigmentati0.94523983
105MP0001970_abnormal_pain_threshold0.94215259
106MP0000470_abnormal_stomach_morphology0.94173567
107MP0003111_abnormal_nucleus_morphology0.91898503
108MP0002067_abnormal_sensory_capabilities0.91506275
109MP0002932_abnormal_joint_morphology0.91290125
110MP0000371_diluted_coat_color0.91106642
111MP0004859_abnormal_synaptic_plasticity0.90526517
112MP0002822_catalepsy0.90507538
113MP0001324_abnormal_eye_pigmentation0.90481576
114MP0002557_abnormal_social/conspecific_i0.89721973
115MP0002184_abnormal_innervation0.88692754
116MP0003935_abnormal_craniofacial_develop0.87679366
117MP0001186_pigmentation_phenotype0.87082265
118MP0003861_abnormal_nervous_system0.86604922
119MP0003634_abnormal_glial_cell0.85429979
120MP0002734_abnormal_mechanical_nocicepti0.84866684
121MP0000647_abnormal_sebaceous_gland0.84738593
122MP0003567_abnormal_fetal_cardiomyocyte0.84650779
123MP0004270_analgesia0.84049647
124MP0005391_vision/eye_phenotype0.83859199
125MP0005187_abnormal_penis_morphology0.83036950
126MP0001485_abnormal_pinna_reflex0.82702213
127MP0003718_maternal_effect0.81939723
128MP0001963_abnormal_hearing_physiology0.81746799
129MP0003635_abnormal_synaptic_transmissio0.80767722
130MP0005646_abnormal_pituitary_gland0.79714252
131MP0002152_abnormal_brain_morphology0.78398173
132MP0001672_abnormal_embryogenesis/_devel0.77452134
133MP0005380_embryogenesis_phenotype0.77452134
134MP0001145_abnormal_male_reproductive0.77219705
135MP0000432_abnormal_head_morphology0.74967469
136MP0004264_abnormal_extraembryonic_tissu0.74105678
137MP0005266_abnormal_metabolism0.73992999
138MP0002882_abnormal_neuron_morphology0.73635346
139MP0005076_abnormal_cell_differentiation0.71838768
140MP0003633_abnormal_nervous_system0.71598138
141MP0002332_abnormal_exercise_endurance0.70673137
142MP0000678_abnormal_parathyroid_gland0.69717494
143MP0001929_abnormal_gametogenesis0.69159834
144MP0005195_abnormal_posterior_eye0.69076610
145MP0002066_abnormal_motor_capabilities/c0.69000606
146MP0010768_mortality/aging0.65380905
147MP0004811_abnormal_neuron_physiology0.64838292
148MP0002938_white_spotting0.64616324
149MP0003077_abnormal_cell_cycle0.64188480
150MP0003698_abnormal_male_reproductive0.63864234
151MP0000467_abnormal_esophagus_morphology0.63694898
152MP0002210_abnormal_sex_determination0.63571403

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.64948178
2Rib fusion (HP:0000902)5.59786503
3Rectovaginal fistula (HP:0000143)4.66829472
4Rectal fistula (HP:0100590)4.66829472
5Hyperventilation (HP:0002883)4.66100298
6Facial hemangioma (HP:0000329)4.60223786
7Annular pancreas (HP:0001734)4.48681696
8Increased IgM level (HP:0003496)4.29857274
9Turricephaly (HP:0000262)4.18900960
10Coronal craniosynostosis (HP:0004440)4.17897916
11Intestinal fistula (HP:0100819)4.10295799
12Vaginal fistula (HP:0004320)4.01969297
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.88044201
14Anteriorly placed anus (HP:0001545)3.77093257
15Intestinal atresia (HP:0011100)3.71295282
16Alacrima (HP:0000522)3.69347131
17Alopecia of scalp (HP:0002293)3.67526459
18Tongue fasciculations (HP:0001308)3.65335362
19Hypochromic microcytic anemia (HP:0004840)3.61706809
20Poikiloderma (HP:0001029)3.55038617
21Orthostatic hypotension (HP:0001278)3.46318771
22Absent radius (HP:0003974)3.42931143
23Short humerus (HP:0005792)3.35252359
24Clumsiness (HP:0002312)3.34603159
25Aplasia/hypoplasia of the humerus (HP:0006507)3.34479381
26Aplasia involving forearm bones (HP:0009822)3.32882704
27Absent forearm bone (HP:0003953)3.32882704
28Methylmalonic aciduria (HP:0012120)3.30391226
29Septo-optic dysplasia (HP:0100842)3.29821871
30Colon cancer (HP:0003003)3.29305841
31Ulnar bowing (HP:0003031)3.27677494
32Abnormality of the labia minora (HP:0012880)3.27501873
33Pustule (HP:0200039)3.26416990
34Broad alveolar ridges (HP:0000187)3.24022684
35Muscle fibrillation (HP:0010546)3.21100920
36Male infertility (HP:0003251)3.21022509
37Neoplasm of the adrenal cortex (HP:0100641)3.15069027
38Vertebral hypoplasia (HP:0008417)3.11383223
39Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.11383223
40Abnormality of the aortic arch (HP:0012303)3.05449623
41Large for gestational age (HP:0001520)3.00843600
42Dysautonomia (HP:0002459)2.97635144
43Acute necrotizing encephalopathy (HP:0006965)2.97615439
44Abnormal hemoglobin (HP:0011902)2.96182934
45Short chin (HP:0000331)2.92966691
46Narrow nasal bridge (HP:0000446)2.91803890
47Abnormality of male internal genitalia (HP:0000022)2.86081675
48Congenital hip dislocation (HP:0001374)2.84908763
49Abnormal respiratory motile cilium morphology (HP:0005938)2.81803225
50Abnormal respiratory epithelium morphology (HP:0012253)2.81803225
51Decreased lacrimation (HP:0000633)2.81518015
52Pancreatic fibrosis (HP:0100732)2.81115436
53Acute encephalopathy (HP:0006846)2.79688678
54Pancreatic cysts (HP:0001737)2.77838771
55Hamartoma (HP:0010566)2.76909166
56Premature skin wrinkling (HP:0100678)2.72762302
57Hypotelorism (HP:0000601)2.70060221
58Optic nerve hypoplasia (HP:0000609)2.68473683
59Neoplasm of the adrenal gland (HP:0100631)2.66462093
60Medial flaring of the eyebrow (HP:0010747)2.61859259
61Bifid uvula (HP:0000193)2.60829442
62Absent thumb (HP:0009777)2.60622604
63True hermaphroditism (HP:0010459)2.58880023
64Volvulus (HP:0002580)2.57982788
65Aplasia of the musculature (HP:0100854)2.57657359
66Oligodactyly (hands) (HP:0001180)2.54112352
67Supernumerary spleens (HP:0009799)2.52891782
68Patellar aplasia (HP:0006443)2.52105156
69Hypotrichosis (HP:0001006)2.51346593
70Abnormal mitochondria in muscle tissue (HP:0008316)2.50139213
71Choanal stenosis (HP:0000452)2.49690985
72Thickened helices (HP:0000391)2.49316956
73Amelogenesis imperfecta (HP:0000705)2.45861487
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44280967
75Pancreatic islet-cell hyperplasia (HP:0004510)2.44242381
76Median cleft lip (HP:0000161)2.44124659
77Mucopolysacchariduria (HP:0008155)2.41869615
78Urinary glycosaminoglycan excretion (HP:0003541)2.41869615
79Squamous cell carcinoma (HP:0002860)2.39268641
80Albinism (HP:0001022)2.39089870
81Progressive macrocephaly (HP:0004481)2.38955500
82Hyperglycinemia (HP:0002154)2.38727875
83Selective tooth agenesis (HP:0001592)2.35039828
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.33310010
85Gastrointestinal atresia (HP:0002589)2.33132537
86Nephrogenic diabetes insipidus (HP:0009806)2.30767377
87Growth hormone excess (HP:0000845)2.30540514
88Absent septum pellucidum (HP:0001331)2.30524420
89Pendular nystagmus (HP:0012043)2.28807592
90Focal motor seizures (HP:0011153)2.28270683
91Aplasia/Hypoplasia of the patella (HP:0006498)2.26977801
92Sclerocornea (HP:0000647)2.24921323
93Abnormality of midbrain morphology (HP:0002418)2.20820918
94Molar tooth sign on MRI (HP:0002419)2.20820918
95Mitochondrial inheritance (HP:0001427)2.20490224
96Abnormal lung lobation (HP:0002101)2.19181477
97Hypokinesia (HP:0002375)2.18748046
98Premature graying of hair (HP:0002216)2.16710303
99Hepatoblastoma (HP:0002884)2.15933370
100Diaphragmatic weakness (HP:0009113)2.15206743
101Atonic seizures (HP:0010819)2.14953100
102Abnormality of polysaccharide metabolism (HP:0011012)2.14581062
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14581062
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14581062
105Vaginal atresia (HP:0000148)2.14286393
106Increased CSF lactate (HP:0002490)2.14043776
107Vertebral fusion (HP:0002948)2.12248167
108Dysostosis multiplex (HP:0000943)2.12211568
109Capillary hemangiomas (HP:0005306)2.12072608
110Poor suck (HP:0002033)2.11369302
111Epileptic encephalopathy (HP:0200134)2.11302661
112Hypoplasia of the ulna (HP:0003022)2.10421919
113Genital tract atresia (HP:0001827)2.10130357
114Popliteal pterygium (HP:0009756)2.09543855
115Decreased central vision (HP:0007663)2.08904347
116Acute lymphatic leukemia (HP:0006721)2.07966042
117Cortical dysplasia (HP:0002539)2.07380535
118Abnormality of the ileum (HP:0001549)2.06403835
119Growth hormone deficiency (HP:0000824)2.06109196
120Increased number of teeth (HP:0011069)2.05511287
121Hypoplasia of the radius (HP:0002984)2.05293805
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.04725974
123Split hand (HP:0001171)2.04521658
124Meckel diverticulum (HP:0002245)2.04009274
125Ectopic anus (HP:0004397)2.03139726
126Nephronophthisis (HP:0000090)2.02938391
127Amblyopia (HP:0000646)2.01977526
128Abnormal number of incisors (HP:0011064)2.01317550
129Bulbar palsy (HP:0001283)2.00694674
130Astrocytoma (HP:0009592)2.00340903
131Abnormality of the astrocytes (HP:0100707)2.00340903
132Basal cell carcinoma (HP:0002671)1.99269114
133Increased hepatocellular lipid droplets (HP:0006565)1.99030658
134Drooling (HP:0002307)1.98625130
135Stenosis of the external auditory canal (HP:0000402)1.98200692
136Oligodactyly (HP:0012165)1.97907206
137Diminished movement (HP:0002374)1.97005547
138Anencephaly (HP:0002323)1.96636715
139Bifid tongue (HP:0010297)1.96145235
140Lipid accumulation in hepatocytes (HP:0006561)1.94873379
141Cerebral edema (HP:0002181)1.94401470
142Gait imbalance (HP:0002141)1.92734542
143Febrile seizures (HP:0002373)1.89896418
144Specific learning disability (HP:0001328)1.89737710
145Small hand (HP:0200055)1.88235481
146Congenital primary aphakia (HP:0007707)1.88210935
147Broad-based gait (HP:0002136)1.87534177
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86877645
149Polyphagia (HP:0002591)1.86520360
150Tented upper lip vermilion (HP:0010804)1.85565477
151Joint stiffness (HP:0001387)1.85295962
152Esophageal atresia (HP:0002032)1.84003979
153Postaxial hand polydactyly (HP:0001162)1.83431797
154Aplasia/Hypoplasia of the ulna (HP:0006495)1.82847100
155Bilateral microphthalmos (HP:0007633)1.81552543
156Hemivertebrae (HP:0002937)1.81117803
157Preaxial hand polydactyly (HP:0001177)1.81020875
158Anophthalmia (HP:0000528)1.80875731
159Duodenal stenosis (HP:0100867)1.80086450
160Small intestinal stenosis (HP:0012848)1.80086450
161Synostosis involving the elbow (HP:0003938)1.79904010
162Humeroradial synostosis (HP:0003041)1.79904010
163Maternal diabetes (HP:0009800)1.79539775
164Abnormality of the duodenum (HP:0002246)1.79259246
165Broad foot (HP:0001769)1.78835467
166Abnormality of chromosome stability (HP:0003220)1.78397930
167Abnormality of the septum pellucidum (HP:0007375)1.76551730
168Optic disc pallor (HP:0000543)1.76409795
169Astigmatism (HP:0000483)1.76141288
170Lissencephaly (HP:0001339)1.75999783
171Excessive salivation (HP:0003781)1.75201045
172Poor coordination (HP:0002370)1.72380987
173Labial hypoplasia (HP:0000066)1.71081517
174Abnormality of the renal medulla (HP:0100957)1.70903425
175Congenital stationary night blindness (HP:0007642)1.70702691
176Leukodystrophy (HP:0002415)1.70503400
177Thyroid-stimulating hormone excess (HP:0002925)1.70449179
178Birth length less than 3rd percentile (HP:0003561)1.70403128
179Retinal dysplasia (HP:0007973)1.70279629
180Bile duct proliferation (HP:0001408)1.70093318
181Abnormal biliary tract physiology (HP:0012439)1.70093318
182Triphalangeal thumb (HP:0001199)1.70063658
183Glioma (HP:0009733)1.69922918
184Limb dystonia (HP:0002451)1.69496327
185Dandy-Walker malformation (HP:0001305)1.68346680
186Anterior segment dysgenesis (HP:0007700)1.66040081
187Cystic liver disease (HP:0006706)1.65061620
188Hypoplastic female external genitalia (HP:0012815)1.64961047
189Myokymia (HP:0002411)1.63832076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.87738875
2MAPK155.66139711
3DDR24.71687598
4MAP3K64.66782047
5WNK33.51285182
6PINK13.29502056
7TRIM283.25368219
8FGR3.14213493
9TYRO33.01265250
10MAP3K112.94340077
11UHMK12.83695695
12MATK2.83560321
13MARK12.70808076
14PRKD22.64690862
15DAPK12.64017009
16WEE12.63394760
17YES12.45749384
18BCR2.19672411
19MAP2K72.16544222
20BMX2.10563940
21AKT32.08121338
22ZAK1.94137366
23CSNK1G31.84298755
24DYRK1B1.82161019
25CSNK1G21.81915399
26PIM21.80438145
27BMPR1B1.74572576
28CSK1.71749913
29TSSK61.67125492
30PNCK1.63785219
31PLK31.63612847
32PHKG21.62457316
33PHKG11.62457316
34MAP4K21.57564754
35CSNK1A1L1.56639908
36SRPK11.52803094
37MKNK11.52495358
38PDGFRA1.49107309
39CDK71.47924836
40VRK21.47663893
41PLK41.45104245
42VRK11.42163406
43TTK1.41592913
44FRK1.40476266
45PLK21.40046897
46STK161.37756908
47PRPF4B1.31586778
48LATS21.27646205
49CDK61.27057702
50CDC42BPA1.21479694
51NUAK11.13813009
52STK38L1.13400104
53CHEK21.09795497
54RPS6KC11.08523964
55RPS6KL11.08523964
56TAF11.06768982
57MINK11.05536819
58BCKDK1.04762392
59ACVR1B1.04189331
60PIM11.02446089
61PRKCG1.01258279
62TRPM70.99809239
63GSK3A0.95787572
64BRSK20.94299308
65MAPK110.93375618
66RPS6KA60.91100542
67CCNB10.89560419
68CASK0.87536445
69DYRK1A0.81949080
70NME10.81523328
71NEK10.80098739
72RPS6KA40.75287974
73NTRK20.74515627
74CAMK2B0.73920908
75OXSR10.73508159
76DYRK30.72135636
77PAK30.70532121
78PLK10.70373935
79CDK80.69470322
80FGFR20.68468063
81TAOK20.65816596
82INSRR0.63628033
83PRKAA10.62645400
84HIPK20.61785020
85DYRK20.60093694
86BRSK10.60055633
87CAMK2G0.58601719
88SIK30.57436480
89CAMK2A0.56994881
90BRD40.56740145
91RPS6KA10.56416818
92CSNK1A10.56043102
93GRK50.55129632
94MAP3K90.54060188
95GRK10.52171644
96EPHB20.51408121
97PKN10.50480152
98TNIK0.50335492
99MAP2K40.49839565
100EIF2AK30.49779543
101TIE10.49110057
102ATR0.48770950
103ADRBK20.47877118
104CSNK1D0.47697972
105PRKD30.47399590
106MAPKAPK50.47398277
107CDK30.47368723
108MKNK20.46498562
109PRKCE0.46381050
110TGFBR10.46275768
111RPS6KB10.45339219
112CDK20.45281264
113CDK11A0.45250991
114EIF2AK20.45056355
115SGK4940.44812704
116SGK2230.44812704
117CDK150.44276181
118CSNK2A10.43153093
119AURKB0.43025361
120GRK70.42814760
121CDK180.42805631
122AURKA0.42266475
123MTOR0.41862219
124EPHA40.41141510
125NEK20.40865093
126STK390.40848975
127CAMK2D0.40641021
128RPS6KA50.38262044
129CDK190.38038341
130RAF10.37854879
131SGK10.37708073
132MAPK100.37503751
133WNK40.37060530
134CSNK1G10.37023680
135EPHA30.36976907
136MAPK40.34985912
137EGFR0.33652113
138CHEK10.32230469
139ERBB30.32091498
140CDK140.32018333
141MAPK30.31711152
142CSNK2A20.31593598
143TNK20.31318743
144MARK20.30197062
145MAPK140.29685999
146CDK10.29256423
147MUSK0.29101911
148MAPK10.29012836
149LYN0.28720511
150PRKCZ0.26701327
151NTRK30.26376518
152RPS6KA30.25075741
153BUB10.24911846
154GSK3B0.24832484
155CDC70.22270303
156INSR0.21443294
157PRKAA20.21283149
158CDK50.20072304
159ATM0.19622933
160PAK60.19361881
161MAP3K40.18817195
162MAP3K100.17367290
163EPHA20.16279309
164PDGFRB0.16170682
165SIK20.15594697
166CDK120.14422975
167PRKACG0.14412702
168MAPK130.14176385
169CSNK1E0.13947913

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.08202662
2Mismatch repair_Homo sapiens_hsa034304.93640158
3Base excision repair_Homo sapiens_hsa034104.33220615
4DNA replication_Homo sapiens_hsa030303.47735980
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.11594087
6Propanoate metabolism_Homo sapiens_hsa006402.75279932
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74390464
8Protein export_Homo sapiens_hsa030602.71024334
9Parkinsons disease_Homo sapiens_hsa050122.64999635
10Circadian rhythm_Homo sapiens_hsa047102.49038502
11Nucleotide excision repair_Homo sapiens_hsa034202.27350748
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22245531
13Non-homologous end-joining_Homo sapiens_hsa034502.12438052
14Spliceosome_Homo sapiens_hsa030402.12036038
15Homologous recombination_Homo sapiens_hsa034402.10185970
16Hedgehog signaling pathway_Homo sapiens_hsa043402.06445631
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99790684
18Arginine and proline metabolism_Homo sapiens_hsa003301.99614764
19Fanconi anemia pathway_Homo sapiens_hsa034601.96164969
20mRNA surveillance pathway_Homo sapiens_hsa030151.95947437
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87305289
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79307177
23Hippo signaling pathway_Homo sapiens_hsa043901.76111875
24Alzheimers disease_Homo sapiens_hsa050101.73192548
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72545428
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64464348
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64168354
28Notch signaling pathway_Homo sapiens_hsa043301.61257230
29RNA transport_Homo sapiens_hsa030131.57817901
30Fatty acid metabolism_Homo sapiens_hsa012121.54990015
31mTOR signaling pathway_Homo sapiens_hsa041501.49985180
32Biosynthesis of amino acids_Homo sapiens_hsa012301.49051907
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39865623
34Nicotine addiction_Homo sapiens_hsa050331.36172861
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35259043
36Wnt signaling pathway_Homo sapiens_hsa043101.34219936
37Sulfur relay system_Homo sapiens_hsa041221.33757310
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31268697
39Basal cell carcinoma_Homo sapiens_hsa052171.26758314
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22364519
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22336594
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22240051
43Phototransduction_Homo sapiens_hsa047441.15598478
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12446407
45p53 signaling pathway_Homo sapiens_hsa041151.10022028
46Oocyte meiosis_Homo sapiens_hsa041141.08301258
47Butanoate metabolism_Homo sapiens_hsa006501.08281177
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06639478
49Bladder cancer_Homo sapiens_hsa052191.06246751
50TGF-beta signaling pathway_Homo sapiens_hsa043501.06103855
51Adherens junction_Homo sapiens_hsa045201.04332728
52Cell cycle_Homo sapiens_hsa041100.99509643
53Fructose and mannose metabolism_Homo sapiens_hsa000510.98688416
54Pyruvate metabolism_Homo sapiens_hsa006200.98239088
55Gap junction_Homo sapiens_hsa045400.97220342
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.92540231
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91507104
58Purine metabolism_Homo sapiens_hsa002300.89949561
59GABAergic synapse_Homo sapiens_hsa047270.88514945
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84937785
61Steroid biosynthesis_Homo sapiens_hsa001000.83431152
62One carbon pool by folate_Homo sapiens_hsa006700.82758444
63Dorso-ventral axis formation_Homo sapiens_hsa043200.81288871
64Carbon metabolism_Homo sapiens_hsa012000.81200306
65Fatty acid elongation_Homo sapiens_hsa000620.79756759
66beta-Alanine metabolism_Homo sapiens_hsa004100.79751205
67ErbB signaling pathway_Homo sapiens_hsa040120.77230196
68Selenocompound metabolism_Homo sapiens_hsa004500.76532544
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74073298
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73748043
71Folate biosynthesis_Homo sapiens_hsa007900.69433949
72Colorectal cancer_Homo sapiens_hsa052100.67592826
73Peroxisome_Homo sapiens_hsa041460.67072322
74Metabolic pathways_Homo sapiens_hsa011000.65843339
75Choline metabolism in cancer_Homo sapiens_hsa052310.65218099
76Lysine degradation_Homo sapiens_hsa003100.63094815
77Amphetamine addiction_Homo sapiens_hsa050310.61762162
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59427228
79VEGF signaling pathway_Homo sapiens_hsa043700.59098593
80Long-term depression_Homo sapiens_hsa047300.58843604
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58328368
82Alcoholism_Homo sapiens_hsa050340.57439858
83Shigellosis_Homo sapiens_hsa051310.55513386
84Cocaine addiction_Homo sapiens_hsa050300.55232412
85Basal transcription factors_Homo sapiens_hsa030220.53363131
86Vitamin B6 metabolism_Homo sapiens_hsa007500.52715983
87Tryptophan metabolism_Homo sapiens_hsa003800.52650434
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52398952
89Regulation of autophagy_Homo sapiens_hsa041400.50666728
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50365738
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49632296
92Tight junction_Homo sapiens_hsa045300.48936331
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48823139
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46751238
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46095576
96Primary immunodeficiency_Homo sapiens_hsa053400.44322438
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43241813
98Ribosome_Homo sapiens_hsa030100.43050679
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.43029043
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42820835
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42335743
102Glutamatergic synapse_Homo sapiens_hsa047240.42078174
103MAPK signaling pathway_Homo sapiens_hsa040100.41731107
104Morphine addiction_Homo sapiens_hsa050320.41459454
105Huntingtons disease_Homo sapiens_hsa050160.40247973
106Ether lipid metabolism_Homo sapiens_hsa005650.39848032
107Synaptic vesicle cycle_Homo sapiens_hsa047210.39766232
108MicroRNAs in cancer_Homo sapiens_hsa052060.39632780
109Galactose metabolism_Homo sapiens_hsa000520.38918633
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38589619
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37550169
112RNA polymerase_Homo sapiens_hsa030200.37312606
113Tyrosine metabolism_Homo sapiens_hsa003500.36336259
114Nitrogen metabolism_Homo sapiens_hsa009100.35618624
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.35285006
116Arginine biosynthesis_Homo sapiens_hsa002200.35016371
117Fatty acid degradation_Homo sapiens_hsa000710.33394134
118GnRH signaling pathway_Homo sapiens_hsa049120.32018173
119Insulin signaling pathway_Homo sapiens_hsa049100.31551605
120Dopaminergic synapse_Homo sapiens_hsa047280.30437458
121Proteasome_Homo sapiens_hsa030500.28898143
122Olfactory transduction_Homo sapiens_hsa047400.28361559
123RNA degradation_Homo sapiens_hsa030180.28335761
124Cardiac muscle contraction_Homo sapiens_hsa042600.26821316
125Oxidative phosphorylation_Homo sapiens_hsa001900.26230466
126AMPK signaling pathway_Homo sapiens_hsa041520.24122958
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23928243
128Collecting duct acid secretion_Homo sapiens_hsa049660.23237999
129Glutathione metabolism_Homo sapiens_hsa004800.22737885
130Melanogenesis_Homo sapiens_hsa049160.20640516
131Linoleic acid metabolism_Homo sapiens_hsa005910.20061154
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18113906
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17921023
134Mineral absorption_Homo sapiens_hsa049780.17430661
135Serotonergic synapse_Homo sapiens_hsa047260.16172364
136Axon guidance_Homo sapiens_hsa043600.15835873
137Taste transduction_Homo sapiens_hsa047420.15488570
138Estrogen signaling pathway_Homo sapiens_hsa049150.15399842
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13548310
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.13116585
141Pyrimidine metabolism_Homo sapiens_hsa002400.12515145
142Insulin secretion_Homo sapiens_hsa049110.12300004
143Circadian entrainment_Homo sapiens_hsa047130.11897238

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