GPR20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kidney mesenchyme development (GO:0072074)9.53258381
2cell proliferation involved in metanephros development (GO:0072203)7.77168708
3metanephric mesenchyme development (GO:0072075)7.22388913
4cell proliferation involved in kidney development (GO:0072111)7.13766354
5mitochondrial DNA metabolic process (GO:0032042)7.12057130
6glomerulus development (GO:0032835)6.55888610
7pattern specification involved in kidney development (GO:0061004)6.54186008
8folic acid metabolic process (GO:0046655)6.18974279
9atrioventricular valve morphogenesis (GO:0003181)6.03319453
10mesenchyme morphogenesis (GO:0072132)5.86646333
11endocardial cushion morphogenesis (GO:0003203)5.64183611
12T cell apoptotic process (GO:0070231)5.64140852
13DNA-dependent DNA replication (GO:0006261)5.60845389
14cGMP-mediated signaling (GO:0019934)5.40151189
15DNA replication checkpoint (GO:0000076)5.19306739
16mesenchymal cell differentiation involved in renal system development (GO:2001012)5.08603023
17mesenchymal cell differentiation involved in kidney development (GO:0072161)5.08603023
18mesenchymal cell development (GO:0014031)4.91384556
19establishment of tissue polarity (GO:0007164)4.88421328
20establishment of planar polarity (GO:0001736)4.88421328
21lymphocyte apoptotic process (GO:0070227)4.84747346
22negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.83913625
23daunorubicin metabolic process (GO:0044597)4.82414592
24polyketide metabolic process (GO:0030638)4.82414592
25doxorubicin metabolic process (GO:0044598)4.82414592
26cardiac epithelial to mesenchymal transition (GO:0060317)4.79197825
27cell migration involved in heart development (GO:0060973)4.75316413
28rRNA modification (GO:0000154)4.72769822
29cell differentiation involved in metanephros development (GO:0072202)4.66801322
30epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.65751946
31response to folic acid (GO:0051593)4.59826232
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.47718127
33negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.46682594
34smooth muscle tissue development (GO:0048745)4.46142941
35mesonephros development (GO:0001823)4.45322801
36negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.38244808
37glomerular filtration (GO:0003094)4.33589708
38heart valve morphogenesis (GO:0003179)4.21941535
39positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.10760389
40regulation of mesenchymal cell apoptotic process (GO:2001053)4.09557150
41stem cell development (GO:0048864)4.09084105
42negative regulation of cell cycle G2/M phase transition (GO:1902750)4.01741187
43rRNA methylation (GO:0031167)3.99078127
44endothelium development (GO:0003158)3.98888364
45respiratory tube development (GO:0030323)3.95473322
46positive regulation of gastrulation (GO:2000543)3.93000930
47positive regulation of vascular permeability (GO:0043117)3.91354492
48mesenchymal cell proliferation (GO:0010463)3.84827790
49ventricular trabecula myocardium morphogenesis (GO:0003222)3.84375742
50regulation of apoptotic process involved in morphogenesis (GO:1902337)3.82265377
51negative regulation of striated muscle cell apoptotic process (GO:0010664)3.80842683
52renal filtration (GO:0097205)3.72259845
53head development (GO:0060322)3.71107609
54proteasome assembly (GO:0043248)3.70433189
55positive regulation of metanephros development (GO:0072216)3.69725968
56regulation of mesoderm development (GO:2000380)3.68672137
57Notch signaling involved in heart development (GO:0061314)3.65836985
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65175323
59nephron tubule development (GO:0072080)3.59822574
60somite rostral/caudal axis specification (GO:0032525)3.58650794
61positive regulation of endothelial cell apoptotic process (GO:2000353)3.54796396
62regulation of stem cell maintenance (GO:2000036)3.54196777
63vascular endothelial growth factor signaling pathway (GO:0038084)3.54101711
64chromatin remodeling at centromere (GO:0031055)3.53668042
65glomerular basement membrane development (GO:0032836)3.53611185
66artery development (GO:0060840)3.51057290
67cytoplasmic mRNA processing body assembly (GO:0033962)3.49868323
68protein heterotrimerization (GO:0070208)3.49683304
69leukocyte apoptotic process (GO:0071887)3.46422511
70mesenchymal cell differentiation (GO:0048762)3.45075006
71endocardial cushion development (GO:0003197)3.44898032
72neural crest cell development (GO:0014032)3.43368745
73CENP-A containing nucleosome assembly (GO:0034080)3.41132281
74positive regulation of calcium ion import (GO:0090280)3.35907161
75renal tubule development (GO:0061326)3.35822067
76aorta morphogenesis (GO:0035909)3.34982913
77lung vasculature development (GO:0060426)3.33248609
78lymph vessel development (GO:0001945)3.32570574
79negative regulation of androgen receptor signaling pathway (GO:0060766)3.30041905
80primitive streak formation (GO:0090009)3.28217506
81heart trabecula morphogenesis (GO:0061384)3.27251538
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25728589
83establishment of apical/basal cell polarity (GO:0035089)3.19707021
84diaphragm development (GO:0060539)3.17594744
85positive regulation of kidney development (GO:0090184)3.15026437
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13755787
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.13755787
88mesenchyme development (GO:0060485)3.13472533
89nephron epithelium development (GO:0072009)3.13468906
90coronary vasculature morphogenesis (GO:0060977)3.11391893
91negative regulation of metanephros development (GO:0072217)3.11333010
92receptor guanylyl cyclase signaling pathway (GO:0007168)3.10856166
93regulation of glomerulus development (GO:0090192)3.10558069
94folic acid-containing compound metabolic process (GO:0006760)3.10165842
95negative regulation of chondrocyte differentiation (GO:0032331)3.09217210
96smooth muscle cell differentiation (GO:0051145)3.05417750
97regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.04963844
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04840917
99heart valve formation (GO:0003188)3.03839815
100dorsal/ventral neural tube patterning (GO:0021904)3.03400422
101purine ribonucleotide transport (GO:0015868)3.01912092
102regulation of cell proliferation involved in kidney development (GO:1901722)3.00375088
103negative regulation of cartilage development (GO:0061037)2.98887990
104regulation of metanephros development (GO:0072215)2.98860896
105anterior/posterior axis specification (GO:0009948)2.98756058
106nephron epithelium morphogenesis (GO:0072088)2.98551998
107nephron tubule morphogenesis (GO:0072078)2.98551998
108notochord development (GO:0030903)2.96354396
109tetrahydrofolate metabolic process (GO:0046653)2.96320507
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95809808
111urogenital system development (GO:0001655)2.95321939
112renal tubule morphogenesis (GO:0061333)2.94919578
113viral transcription (GO:0019083)2.93946073
114renal system development (GO:0072001)2.93404621
115positive regulation of cardiac muscle cell differentiation (GO:2000727)2.92956240
116folic acid-containing compound biosynthetic process (GO:0009396)2.92830802
117cell surface receptor signaling pathway involved in heart development (GO:0061311)2.92041286
118histone-serine phosphorylation (GO:0035404)2.91722690
119regulation of transforming growth factor beta2 production (GO:0032909)2.91334138
120adenine nucleotide transport (GO:0051503)2.90725066
121regulation of kidney development (GO:0090183)2.90352399
122tonic smooth muscle contraction (GO:0014820)2.90061479
123negative regulation of stem cell proliferation (GO:2000647)2.89918482
124mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.89749890
125cardiovascular system development (GO:0072358)2.89117438
126establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.87640568
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87364905
128negative regulation of ligase activity (GO:0051352)2.87364905
129negative regulation of kidney development (GO:0090185)2.85785805
130negative regulation of myoblast differentiation (GO:0045662)2.85711642
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85549044
132ventricular septum morphogenesis (GO:0060412)2.85254941
133regulation of smooth muscle cell differentiation (GO:0051150)2.83626693
134embryonic digestive tract development (GO:0048566)2.83614860
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.83533734
136glomerular visceral epithelial cell development (GO:0072015)2.83082617
137polarized epithelial cell differentiation (GO:0030859)2.82653833
138aminoglycoside antibiotic metabolic process (GO:0030647)2.82636577
139retina vasculature morphogenesis in camera-type eye (GO:0061299)2.82149634
140type B pancreatic cell development (GO:0003323)2.81533565
141folic acid transport (GO:0015884)2.81096447
142termination of RNA polymerase III transcription (GO:0006386)2.80921631
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.80921631
144cell differentiation involved in kidney development (GO:0061005)2.80794301
145energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80030480
146ATP synthesis coupled proton transport (GO:0015986)2.80030480
147heterochromatin organization (GO:0070828)2.79676383
148DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79654808
149positive regulation of SMAD protein import into nucleus (GO:0060391)2.79367928
150translational termination (GO:0006415)2.77691427
151signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75415405
152intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75415405
153positive regulation of uterine smooth muscle contraction (GO:0070474)2.74694855
154positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74549441
155positive regulation of DNA biosynthetic process (GO:2000573)2.74402249
156epithelial to mesenchymal transition (GO:0001837)2.71765710
157signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71033720
158signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71033720
159signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71033720
160skeletal muscle organ development (GO:0060538)2.69766275
161skeletal muscle tissue regeneration (GO:0043403)2.68402660
162positive regulation of prostaglandin secretion (GO:0032308)2.68036865
163regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.67102317
164kidney morphogenesis (GO:0060993)2.67092768
165establishment or maintenance of monopolar cell polarity (GO:0061339)2.66167313
166establishment of monopolar cell polarity (GO:0061162)2.66167313
167negative regulation of homotypic cell-cell adhesion (GO:0034111)2.66012081
168deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65921903
169mitotic metaphase plate congression (GO:0007080)2.65130414
170negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.65043662
171negative regulation of B cell apoptotic process (GO:0002903)2.64830395
172SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64619137
173cotranslational protein targeting to membrane (GO:0006613)2.64157290
174trabecula morphogenesis (GO:0061383)2.63929976
175negative regulation of innate immune response (GO:0045824)2.63831844
176positive regulation of phosphatase activity (GO:0010922)2.63790797
177regulation of endothelial cell differentiation (GO:0045601)2.60870651
178pre-miRNA processing (GO:0031054)2.60770038
179regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.60743130
180DNA replication-independent nucleosome organization (GO:0034724)2.60678974
181DNA replication-independent nucleosome assembly (GO:0006336)2.60678974
182signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59640469
183signal transduction involved in DNA damage checkpoint (GO:0072422)2.59640469
184metanephric epithelium development (GO:0072207)2.59523331
185regulation of response to interferon-gamma (GO:0060330)2.58971761
186GTP biosynthetic process (GO:0006183)2.58362870
187valine metabolic process (GO:0006573)2.58166377
188regulation of striated muscle cell apoptotic process (GO:0010662)2.57945921
189mitochondrial DNA replication (GO:0006264)10.1989977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.42736327
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74377478
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.40350559
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38022323
5EED_16625203_ChIP-ChIP_MESCs_Mouse3.38053171
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.21529032
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06764135
8PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.03384367
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.98399101
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.96240826
11AR_21909140_ChIP-Seq_LNCAP_Human2.94242180
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.87362236
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.87362236
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.87362236
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.81534365
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.75687459
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.74745282
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68286666
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68190888
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64508275
21GBX2_23144817_ChIP-Seq_PC3_Human2.61105593
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58003291
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.54041492
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.45981702
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45024594
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.43383601
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41656582
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40653608
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40653608
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.38526132
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.37812594
32GATA1_22025678_ChIP-Seq_K562_Human2.34285188
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33372174
34JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28375391
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23090819
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.20579609
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18571912
38GABP_17652178_ChIP-ChIP_JURKAT_Human2.17549632
39MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16771136
40BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15763803
41TP63_19390658_ChIP-ChIP_HaCaT_Human2.13965545
42EST1_17652178_ChIP-ChIP_JURKAT_Human2.13186056
43STAT3_1855785_ChIP-Seq_MESCs_Mouse2.12332314
44MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05549079
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.02858301
46SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01195698
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.97332491
48EWS_26573619_Chip-Seq_HEK293_Human1.91562102
49TP53_18474530_ChIP-ChIP_U2OS_Human1.88039042
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87840085
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85187595
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.84749625
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84282334
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.83812445
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81979860
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81564037
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.80633822
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78974489
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78230886
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74176583
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.73073352
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73007440
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.72882132
64XRN2_22483619_ChIP-Seq_HELA_Human1.71024530
65EZH2_22144423_ChIP-Seq_EOC_Human1.70893966
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.69529403
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.68893076
68FUS_26573619_Chip-Seq_HEK293_Human1.67253010
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66036263
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65676149
71TP53_16413492_ChIP-PET_HCT116_Human1.65469300
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.63447954
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62259381
74VDR_22108803_ChIP-Seq_LS180_Human1.59552464
75TTF2_22483619_ChIP-Seq_HELA_Human1.58751794
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57554762
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.54987864
78* DCP1A_22483619_ChIP-Seq_HELA_Human1.54411134
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.53132202
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52467919
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51123344
82TAF15_26573619_Chip-Seq_HEK293_Human1.50845090
83RNF2_27304074_Chip-Seq_NSC_Mouse1.50250758
84ER_23166858_ChIP-Seq_MCF-7_Human1.49226352
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.48177579
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46233807
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46165879
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44938282
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.44823558
90P300_19829295_ChIP-Seq_ESCs_Human1.44521949
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44075130
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.40555706
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.40124730
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39661545
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39483953
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34818283
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34815611
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34442513
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.32513305
100* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31770361
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.28729896
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28138878
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27631889
104CJUN_26792858_Chip-Seq_BT549_Human1.27223071
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.27157307
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24809345
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24335220
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23452115
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.22322019
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21566495
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21476597
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21366033
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20965638
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20813318
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.19878876
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.19289328
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.18771670
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13464233
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13246616
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12752742
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10731208
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09901239
123SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08684052
124JUN_21703547_ChIP-Seq_K562_Human1.06366254
125TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05980990
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04648381
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04210658
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.03455909
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.02698742
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02590852
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01037293
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00860523
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00301366
134PHF8_20622854_ChIP-Seq_HELA_Human0.99388501
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98924870
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98765808
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.98744575
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98030593
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.97934328
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97837959
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97545470
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96763813
143SMAD4_21799915_ChIP-Seq_A2780_Human0.96484166
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96277311
145GF1B_26923725_Chip-Seq_HPCs_Mouse0.96146089
146THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95986703
147ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95960084
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95332083
149MYC_18940864_ChIP-ChIP_HL60_Human0.94780380
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94478773
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.94374025
152WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92841947
153CLOCK_20551151_ChIP-Seq_293T_Human0.92255055
154ELK1_19687146_ChIP-ChIP_HELA_Human0.91637431
155YY1_21170310_ChIP-Seq_MESCs_Mouse0.91309841
156CBP_20019798_ChIP-Seq_JUKART_Human0.91066651
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91066651
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90519709
159E2F1_20622854_ChIP-Seq_HELA_Human0.90080855
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89979197
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89885423
162NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89826185
163RXR_22108803_ChIP-Seq_LS180_Human0.89379546
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89089259
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.87997169
166NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87628438
167KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86922529
168PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86691369
169EOMES_21245162_ChIP-Seq_HESCs_Human0.86079417
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83402337
171SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81605450
172CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81501497
173GATA1_26923725_Chip-Seq_HPCs_Mouse0.81240700
174OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80566788
175SRF_21415370_ChIP-Seq_HL-1_Mouse0.78880044
176NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.77492800
177TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76861054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.48386752
2MP0003806_abnormal_nucleotide_metabolis4.24018514
3MP0003941_abnormal_skin_development4.07380556
4MP0003279_aneurysm3.86407278
5MP0004272_abnormal_basement_membrane3.78194259
6MP0005623_abnormal_meninges_morphology3.27314231
7MP0006054_spinal_hemorrhage3.05310820
8MP0000767_abnormal_smooth_muscle2.96584806
9MP0006292_abnormal_olfactory_placode2.94371694
10MP0006035_abnormal_mitochondrial_morpho2.78822608
11MP0009384_cardiac_valve_regurgitation2.75977830
12MP0003890_abnormal_embryonic-extraembry2.73029473
13MP0003385_abnormal_body_wall2.64324271
14MP0009278_abnormal_bone_marrow2.58977655
15MP0002234_abnormal_pharynx_morphology2.52615964
16MP0002009_preneoplasia2.49994443
17MP0003119_abnormal_digestive_system2.37296594
18MP0005503_abnormal_tendon_morphology2.35683235
19MP0000534_abnormal_ureter_morphology2.30565981
20MP0003942_abnormal_urinary_system2.27182628
21MP0002249_abnormal_larynx_morphology2.21845322
22MP0002127_abnormal_cardiovascular_syste2.14975093
23MP0003221_abnormal_cardiomyocyte_apopto1.98077292
24MP0002111_abnormal_tail_morphology1.95661150
25MP0005084_abnormal_gallbladder_morpholo1.93782970
26MP0004133_heterotaxia1.92677528
27MP0003122_maternal_imprinting1.84978877
28MP0009697_abnormal_copulation1.83972266
29MP0009250_abnormal_appendicular_skeleto1.81273227
30MP0010030_abnormal_orbit_morphology1.80915871
31MP0001293_anophthalmia1.80420112
32MP0002282_abnormal_trachea_morphology1.77834198
33MP0003121_genomic_imprinting1.76514172
34MP0005330_cardiomyopathy1.74881130
35MP0006138_congestive_heart_failure1.70935144
36MP0003123_paternal_imprinting1.70777823
37MP0005257_abnormal_intraocular_pressure1.68507235
38MP0002098_abnormal_vibrissa_morphology1.67261163
39MP0003787_abnormal_imprinting1.66995152
40MP0001879_abnormal_lymphatic_vessel1.65687905
41MP0004215_abnormal_myocardial_fiber1.61372772
42MP0009053_abnormal_anal_canal1.59363609
43MP0008932_abnormal_embryonic_tissue1.58078489
44MP0000462_abnormal_digestive_system1.57071378
45MP0000678_abnormal_parathyroid_gland1.53162853
46MP0000049_abnormal_middle_ear1.51618945
47MP0003950_abnormal_plasma_membrane1.50579801
48MP0000566_synostosis1.50289679
49MP0005171_absent_coat_pigmentation1.49957428
50MP0000516_abnormal_urinary_system1.49133642
51MP0005367_renal/urinary_system_phenotyp1.49133642
52MP0002102_abnormal_ear_morphology1.47757136
53MP0005595_abnormal_vascular_smooth1.47141642
54MP0001346_abnormal_lacrimal_gland1.45937549
55MP0001286_abnormal_eye_development1.44548792
56MP0005508_abnormal_skeleton_morphology1.42231890
57MP0002751_abnormal_autonomic_nervous1.40038008
58MP0008058_abnormal_DNA_repair1.36751790
59MP0002938_white_spotting1.36160207
60MP0000358_abnormal_cell_content/1.34492144
61MP0005409_darkened_coat_color1.33895906
62MP0000427_abnormal_hair_cycle1.31254216
63MP0008438_abnormal_cutaneous_collagen1.31084885
64MP0010386_abnormal_urinary_bladder1.29573390
65MP0003937_abnormal_limbs/digits/tail_de1.27568960
66MP0004957_abnormal_blastocyst_morpholog1.25823949
67MP0002128_abnormal_blood_circulation1.25552670
68MP0004858_abnormal_nervous_system1.25513271
69MP0003567_abnormal_fetal_cardiomyocyte1.25431801
70MP0000428_abnormal_craniofacial_morphol1.21196069
71MP0010234_abnormal_vibrissa_follicle1.21195998
72MP0003077_abnormal_cell_cycle1.18700830
73MP0002233_abnormal_nose_morphology1.16975832
74MP0006276_abnormal_autonomic_nervous1.16192316
75MP0010307_abnormal_tumor_latency1.15526413
76MP0001672_abnormal_embryogenesis/_devel1.15480750
77MP0005380_embryogenesis_phenotype1.15480750
78MP0005620_abnormal_muscle_contractility1.13892256
79MP0010630_abnormal_cardiac_muscle1.12991094
80MP0000762_abnormal_tongue_morphology1.11341507
81MP0003984_embryonic_growth_retardation1.11173641
82MP0004085_abnormal_heartbeat1.10572127
83MP0002932_abnormal_joint_morphology1.06378486
84MP0001614_abnormal_blood_vessel1.06352023
85MP0002160_abnormal_reproductive_system1.05906769
86MP0003935_abnormal_craniofacial_develop1.05179204
87MP0005165_increased_susceptibility_to1.04135547
88MP0003828_pulmonary_edema1.03578675
89MP0000230_abnormal_systemic_arterial1.03365165
90MP0002088_abnormal_embryonic_growth/wei1.02376959
91MP0001664_abnormal_digestion1.01871537
92MP0006036_abnormal_mitochondrial_physio1.01283973
93MP0003755_abnormal_palate_morphology0.98384499
94MP0002972_abnormal_cardiac_muscle0.97860875
95MP0003566_abnormal_cell_adhesion0.97345115
96MP0000538_abnormal_urinary_bladder0.96104932
97MP0002295_abnormal_pulmonary_circulatio0.96092708
98MP0005164_abnormal_response_to0.95672429
99MP0001542_abnormal_bone_strength0.94267479
100MP0003943_abnormal_hepatobiliary_system0.94068357
101MP0005377_hearing/vestibular/ear_phenot0.94021369
102MP0003878_abnormal_ear_physiology0.94021369
103MP0000751_myopathy0.94011241
104MP0010094_abnormal_chromosome_stability0.93814989
105MP0002085_abnormal_embryonic_tissue0.93697288
106MP0008875_abnormal_xenobiotic_pharmacok0.92842753
107MP0004084_abnormal_cardiac_muscle0.91719414
108MP0005389_reproductive_system_phenotype0.90919975
109MP0001544_abnormal_cardiovascular_syste0.89889469
110MP0005385_cardiovascular_system_phenoty0.89889469
111MP0005397_hematopoietic_system_phenotyp0.89632266
112MP0001545_abnormal_hematopoietic_system0.89632266
113MP0002084_abnormal_developmental_patter0.88664468
114MP0003693_abnormal_embryo_hatching0.87398997
115MP0004185_abnormal_adipocyte_glucose0.86987104
116MP0003938_abnormal_ear_development0.86643467
117MP0002177_abnormal_outer_ear0.86341718
118MP0002928_abnormal_bile_duct0.85236539
119MP0002925_abnormal_cardiovascular_devel0.84080102
120MP0000465_gastrointestinal_hemorrhage0.83992113
121MP0000163_abnormal_cartilage_morphology0.83933192
122MP0003137_abnormal_impulse_conducting0.83698644
123MP0003705_abnormal_hypodermis_morpholog0.82830002
124MP0000537_abnormal_urethra_morphology0.82018194
125MP0002734_abnormal_mechanical_nocicepti0.81834001
126MP0001299_abnormal_eye_distance/0.81534495
127MP0001968_abnormal_touch/_nociception0.80292321
128MP0008775_abnormal_heart_ventricle0.80150692
129MP0001119_abnormal_female_reproductive0.80136273
130MP0005076_abnormal_cell_differentiation0.79668981
131MP0002092_abnormal_eye_morphology0.79306479
132MP0002116_abnormal_craniofacial_bone0.79123757
133MP0001727_abnormal_embryo_implantation0.78659998
134MP0000613_abnormal_salivary_gland0.78064945
135MP0006072_abnormal_retinal_apoptosis0.78039134
136MP0005670_abnormal_white_adipose0.77422923
137MP0003091_abnormal_cell_migration0.77390573
138MP0003136_yellow_coat_color0.76312269
139MP0008007_abnormal_cellular_replicative0.75364045
140MP0005275_abnormal_skin_tensile0.74491382
141MP0001881_abnormal_mammary_gland0.73369029
142MP0009379_abnormal_foot_pigmentation0.72710165
143MP0002109_abnormal_limb_morphology0.72068575
144MP0003315_abnormal_perineum_morphology0.71514757
145MP0002697_abnormal_eye_size0.71004842
146MP0003183_abnormal_peptide_metabolism0.70780435
147MP0000639_abnormal_adrenal_gland0.70465492
148MP0003115_abnormal_respiratory_system0.70238949
149MP0000681_abnormal_thyroid_gland0.68956475
150MP0004147_increased_porphyrin_level0.68399595
151MP0000470_abnormal_stomach_morphology0.68050491
152MP0005501_abnormal_skin_physiology0.67778235
153MP0002653_abnormal_ependyma_morphology0.67259945
154MP0003786_premature_aging0.66896833
155MP0002277_abnormal_respiratory_mucosa0.66037969
156MP0009672_abnormal_birth_weight0.65238211
157MP0003718_maternal_effect0.64920751
158MP0003111_abnormal_nucleus_morphology0.64842682
159MP0003011_delayed_dark_adaptation0.64113248

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.69035053
2Axonal loss (HP:0003447)4.61577750
3Short hallux (HP:0010109)4.38807697
4Duplicated collecting system (HP:0000081)4.24025990
5Follicular hyperkeratosis (HP:0007502)4.13777345
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12641023
7Abnormality of the renal collecting system (HP:0004742)4.04412295
8Birth length less than 3rd percentile (HP:0003561)3.97335547
9Aplasia/Hypoplasia of the hallux (HP:0008362)3.82367561
10Bone cyst (HP:0012062)3.81394086
11Pigmentary retinal degeneration (HP:0001146)3.80374617
12Decreased electroretinogram (ERG) amplitude (HP:0000654)3.66408196
13Hypoplastic left heart (HP:0004383)3.61106618
14Aortic dissection (HP:0002647)3.57217609
15Chromsome breakage (HP:0040012)3.55911730
16Opisthotonus (HP:0002179)3.52524034
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.44391543
18Maternal diabetes (HP:0009800)3.41700852
19Mesomelia (HP:0003027)3.36317083
20Aplasia/Hypoplasia of the tibia (HP:0005772)3.33488922
21Hypoplastic heart (HP:0001961)3.32910639
22Aortic aneurysm (HP:0004942)3.24151490
23Parakeratosis (HP:0001036)3.23899775
24Diastasis recti (HP:0001540)3.21312234
25Macrocytic anemia (HP:0001972)3.18865576
26Megaloblastic anemia (HP:0001889)3.17401973
27Shawl scrotum (HP:0000049)3.13321537
28Neonatal short-limb short stature (HP:0008921)3.09768077
29Hypoplastic pelvis (HP:0008839)2.97166693
30Colon cancer (HP:0003003)2.93706004
31Abnormality of homocysteine metabolism (HP:0010919)2.92978280
32Homocystinuria (HP:0002156)2.92978280
33Abnormality of Sharpey fibers (HP:0100685)2.90548658
34Spastic tetraparesis (HP:0001285)2.86647904
35Chondrocalcinosis (HP:0000934)2.84550112
36Deformed tarsal bones (HP:0008119)2.83861263
37Selective tooth agenesis (HP:0001592)2.82746367
38Unilateral renal agenesis (HP:0000122)2.79548739
39Abnormality of dentin (HP:0010299)2.77988596
40Preaxial foot polydactyly (HP:0001841)2.72180513
41Choroideremia (HP:0001139)2.71627877
42Abnormal mitochondria in muscle tissue (HP:0008316)2.71603806
43Abnormal lung lobation (HP:0002101)2.69557587
44Pulmonary artery stenosis (HP:0004415)2.68905165
45Nausea (HP:0002018)2.68504683
46Duplication of thumb phalanx (HP:0009942)2.66477603
47Aortic regurgitation (HP:0001659)2.65633763
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64744422
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64744422
50Alopecia of scalp (HP:0002293)2.61720911
51Ectopic kidney (HP:0000086)2.57926963
52Renal dysplasia (HP:0000110)2.56354435
53Short tibia (HP:0005736)2.55913453
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.55891001
55Acute necrotizing encephalopathy (HP:0006965)2.55744815
56Broad toe (HP:0001837)2.54513670
57Type 1 muscle fiber predominance (HP:0003803)2.52968624
58Calcaneovalgus deformity (HP:0001848)2.50625401
59Abnormality of alanine metabolism (HP:0010916)2.50088769
60Hyperalaninemia (HP:0003348)2.50088769
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50088769
62Septo-optic dysplasia (HP:0100842)2.49305834
63Recurrent corneal erosions (HP:0000495)2.49021066
64Abnormality of the phalanges of the 2nd finger (HP:0009541)2.48533087
65Hyperglycinuria (HP:0003108)2.47907478
66Meckel diverticulum (HP:0002245)2.43091752
67Cortical dysplasia (HP:0002539)2.42425573
68Ankle contracture (HP:0006466)2.40948716
69Mesangial abnormality (HP:0001966)2.40390832
70Abnormal sex determination (HP:0012244)2.40350603
71Sex reversal (HP:0012245)2.40350603
72Abnormal number of incisors (HP:0011064)2.40089406
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.39547473
74Vertebral hypoplasia (HP:0008417)2.39547473
75Anophthalmia (HP:0000528)2.39166263
76Poor head control (HP:0002421)2.37918845
77Abnormality of the 4th metacarpal (HP:0010012)2.36912583
78Fibular hypoplasia (HP:0003038)2.36680521
79Midline defect of the nose (HP:0004122)2.36196049
80Abnormality of the parietal bone (HP:0002696)2.34939070
81Chorioretinal atrophy (HP:0000533)2.34781545
82Hypercalcemia (HP:0003072)2.34740227
83Morphological abnormality of the middle ear (HP:0008609)2.34535901
84Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.34319340
85Neoplasm of the lung (HP:0100526)2.32948922
86Aplasia involving bones of the extremities (HP:0009825)2.31784878
87Aplasia involving bones of the upper limbs (HP:0009823)2.31784878
88Aplasia of the phalanges of the hand (HP:0009802)2.31784878
89Hypergonadotropic hypogonadism (HP:0000815)2.30131977
90Abnormal umbilical cord blood vessels (HP:0011403)2.30111799
91Single umbilical artery (HP:0001195)2.30111799
92Abnormality of the fetal cardiovascular system (HP:0010948)2.30111799
93Supernumerary spleens (HP:0009799)2.29968654
94Abnormality of incisor morphology (HP:0011063)2.29945481
95Abnormality of the pulmonary veins (HP:0011718)2.29089359
96Broad hallux (HP:0010055)2.25639142
97Acute encephalopathy (HP:0006846)2.25120070
98Abnormality of the ileum (HP:0001549)2.24968991
99Absent eyelashes (HP:0000561)2.24148821
100Pallor (HP:0000980)2.24104982
101Abnormality of the 2nd finger (HP:0004100)2.22627563
102Benign neoplasm of the central nervous system (HP:0100835)2.22541074
103Premature rupture of membranes (HP:0001788)2.20745656
104Type I transferrin isoform profile (HP:0003642)2.19509297
105Nephroblastoma (Wilms tumor) (HP:0002667)2.18075232
106Abnormality of the calcaneus (HP:0008364)2.17344869
107Tinnitus (HP:0000360)2.17207875
108Absent radius (HP:0003974)2.17202369
109Short 4th metacarpal (HP:0010044)2.16295502
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16295502
111Diaphragmatic weakness (HP:0009113)2.15968023
112Myelomeningocele (HP:0002475)2.14128390
113Absent thumb (HP:0009777)2.13309254
114Disproportionate short-trunk short stature (HP:0003521)2.13066385
115Abolished electroretinogram (ERG) (HP:0000550)2.13026081
116Squamous cell carcinoma (HP:0002860)2.12245945
117Aplasia/Hypoplasia of the patella (HP:0006498)2.10189831
118Patellar aplasia (HP:0006443)2.09857458
119Median cleft lip (HP:0000161)2.09710854
120Aplasia/Hypoplasia of the uvula (HP:0010293)2.08523236
121Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.08469115
122Absent forearm bone (HP:0003953)2.08303493
123Aplasia involving forearm bones (HP:0009822)2.08303493
124Abnormal vertebral ossification (HP:0100569)2.08026377
125Protrusio acetabuli (HP:0003179)2.07252031
126Clumsiness (HP:0002312)2.07192549
127Hypoplasia of the uterus (HP:0000013)2.06439149
128Hypothermia (HP:0002045)2.05721497
129Abnormal pancreas size (HP:0012094)2.04828914
130Hypoplasia of the iris (HP:0007676)2.04335277
131Entropion (HP:0000621)2.04127065
132Abnormality of the nasolacrimal system (HP:0000614)2.03585758
133Abnormal number of erythroid precursors (HP:0012131)2.02938338
134Occipital encephalocele (HP:0002085)2.01482343
135Testicular atrophy (HP:0000029)2.00579693
136Broad metatarsal (HP:0001783)2.00546408
137Abnormality of the umbilical cord (HP:0010881)1.99674293
138Neoplasm of the respiratory system (HP:0100606)1.99611685
139Absent eyebrow (HP:0002223)1.98712119
140Patent foramen ovale (HP:0001655)1.97409118
141Cutaneous finger syndactyly (HP:0010554)1.97300545
142Aplasia/hypoplasia of the uterus (HP:0008684)1.96953793
143Embryonal renal neoplasm (HP:0011794)1.96103324
144Tracheoesophageal fistula (HP:0002575)1.95540424
145Triphalangeal thumb (HP:0001199)1.95108109
146Aplasia/Hypoplasia of the fibula (HP:0006492)1.95021203
147Delayed CNS myelination (HP:0002188)1.93684269
148Absent toe (HP:0010760)1.92714293
149Prenatal maternal abnormality (HP:0002686)1.92445984
150Constricted visual fields (HP:0001133)1.92317460
151Multiple lipomas (HP:0001012)1.90737580
152Adrenal hypoplasia (HP:0000835)1.90355679
153Woolly hair (HP:0002224)1.89481538
154Abnormality of the duodenum (HP:0002246)1.89363911
155Abnormality of the sella turcica (HP:0002679)1.89115350
156Reticulocytopenia (HP:0001896)1.88469902
157Nemaline bodies (HP:0003798)1.88363788
158Anencephaly (HP:0002323)1.87987859
159Breast aplasia (HP:0100783)1.87810401
160Conjunctival hamartoma (HP:0100780)1.87714524
161Breech presentation (HP:0001623)1.86659164
162Mild short stature (HP:0003502)1.86291843
163Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.85279463
164Abnormality of the nasal septum (HP:0000419)1.84213205
165Mucosal telangiectasiae (HP:0100579)1.83670718
166Progressive macrocephaly (HP:0004481)1.82906620
167Small intestinal stenosis (HP:0012848)1.82761817
168Duodenal stenosis (HP:0100867)1.82761817
169Biconcave vertebral bodies (HP:0004586)1.82145790
170Renal duplication (HP:0000075)1.82122792
171Cutaneous syndactyly (HP:0012725)1.81043249
172Abnormality of the frontal sinuses (HP:0002687)1.80581315
173Abnormality of the lacrimal duct (HP:0011481)1.80365217
174Potter facies (HP:0002009)1.77022073
175Facial shape deformation (HP:0011334)1.77022073
176Sclerocornea (HP:0000647)1.76727171
177Bilateral microphthalmos (HP:0007633)1.76257208
178Abnormality of the incisor (HP:0000676)1.75645412
179Aplasia/Hypoplasia of the breasts (HP:0010311)1.75034152
180Patchy hypopigmentation of hair (HP:0011365)1.74478008
181Congenital stationary night blindness (HP:0007642)1.73698795
182Amelogenesis imperfecta (HP:0000705)1.73251245
183Abnormality of cells of the erythroid lineage (HP:0012130)1.73247392
184Breast hypoplasia (HP:0003187)1.71277270
185Decreased circulating renin level (HP:0003351)1.66686605
186Abnormality of the right ventricle (HP:0001707)1.66674831
187Abnormality of the phalanges of the 5th finger (HP:0004213)1.66624976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.49353974
2TNIK5.21176657
3PNCK4.37471104
4WEE14.21607005
5INSRR4.02757575
6KIT3.97222006
7VRK23.61587327
8ZAK3.22525088
9PBK2.90502456
10TLK12.89554844
11SIK32.72902980
12PRPF4B2.67773954
13CDC72.59994648
14CDK82.58046365
15MKNK22.55440863
16PLK42.53326216
17TAOK22.35506452
18FRK2.31173417
19TAF12.30219954
20BRSK22.28183375
21NME12.27891829
22EPHB22.24284792
23PDGFRA2.23395127
24CLK12.16558421
25STK38L2.05869707
26DMPK2.02160489
27MARK31.96835610
28WNK31.90063170
29MKNK11.89576492
30MST41.88349054
31MAPK151.84683201
32AKT31.83238201
33SMG11.77906770
34FLT31.68818573
35CDC42BPA1.66984241
36PKN11.64412172
37EPHA41.60698543
38PINK11.57638497
39PAK21.55359786
40EPHB11.54217230
41MAP3K141.47699886
42LIMK11.46382458
43BCR1.38314607
44EPHA31.36988581
45TTN1.36865871
46STK41.23390378
47MAPK131.18998487
48TIE11.18877394
49NEK11.18782341
50MELK1.18292666
51NEK21.17232909
52PTK2B1.14754396
53BUB11.12282967
54ROCK11.12129187
55NTRK11.06494403
56LRRK21.05129304
57TESK11.04937011
58CAMK11.03514994
59TTK1.03368554
60EPHA21.01428522
61PIK3CG0.98384855
62GRK50.95911911
63PLK30.92556709
64YES10.91995300
65MAPK70.89354822
66PIK3CA0.87846674
67SRPK10.85631302
68NUAK10.83106993
69TRPM70.81523795
70IRAK30.80149072
71PRKD30.79708355
72BRSK10.78859882
73VRK10.78857917
74PLK10.77432393
75MAP3K100.77264165
76MAPKAPK50.76803418
77LATS20.74947704
78EIF2AK10.67366374
79RPS6KB20.66123507
80ABL20.63766288
81CASK0.63738056
82IRAK20.62921639
83MARK20.62688477
84PASK0.62635213
85PDGFRB0.62128428
86CDK70.61130001
87CAMK1D0.59546981
88DAPK30.59207109
89MAPK120.58948216
90PLK20.56763781
91ATR0.56092637
92PTK60.55417194
93STK240.54821486
94MAP3K20.54530230
95ERBB30.53472785
96BLK0.53440563
97SGK2230.53112899
98SGK4940.53112899
99EIF2AK20.51776487
100BMX0.50215463
101AURKB0.49080265
102CAMK2G0.46852852
103MAP2K40.46100219
104PRKG20.45008205
105PAK30.44444133
106MAP3K30.44191028
107WNK10.43314397
108MAP2K20.42829817
109PAK10.42734531
110NLK0.41695575
111ADRBK10.41061848
112SIK20.39804695
113TESK20.39653658
114ERBB40.38665895
115STK160.38164730
116NEK60.37001616
117GRK10.35046377
118ERBB20.34240746
119PDK20.33110939
120ICK0.32727636
121BRAF0.32573125
122FER0.32150841
123BMPR20.32047239
124IRAK10.31520692
125SGK20.31296304
126PRKCE0.30414631
127MET0.30168218
128PRKD20.28993708
129AURKA0.28114833
130ROCK20.27882703
131AKT20.27493329
132CAMK2A0.27216286
133PRKG10.27044667
134MST1R0.26915347
135CHEK20.26734157
136IRAK40.26334006
137MAP2K70.26291659
138CAMK2B0.25194972
139CSNK2A10.24071195
140ILK0.22935563
141CCNB10.22505336
142FGFR20.21785415
143TSSK60.21695447
144DYRK30.21546182
145DYRK20.21424330
146MINK10.21230087
147CDK30.20906113
148RPS6KA60.20152868
149PAK40.19984719
150MAPK40.19818632
151PTK20.19768654
152INSR0.19761072
153AKT10.19642107
154TGFBR10.19482681
155CAMK40.19330314
156ZAP700.19070055
157CSNK1A10.19044795
158PRKAA20.18065809
159MAP3K80.17961290
160MAPKAPK20.17386574
161PKN20.17325556
162MAP3K120.17294016
163MAP3K10.16734570

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.10471437
2Folate biosynthesis_Homo sapiens_hsa007905.06832339
3Proteasome_Homo sapiens_hsa030504.25186950
4Ribosome_Homo sapiens_hsa030103.49357790
5One carbon pool by folate_Homo sapiens_hsa006703.10331247
6Vascular smooth muscle contraction_Homo sapiens_hsa042702.89368916
7ECM-receptor interaction_Homo sapiens_hsa045122.82291549
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.73392366
9RNA polymerase_Homo sapiens_hsa030202.69698982
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.68651422
11Mismatch repair_Homo sapiens_hsa034302.64798875
12Focal adhesion_Homo sapiens_hsa045102.54293856
13Notch signaling pathway_Homo sapiens_hsa043302.36913905
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35034168
15Renin secretion_Homo sapiens_hsa049242.23681452
16Dilated cardiomyopathy_Homo sapiens_hsa054142.20500587
17TGF-beta signaling pathway_Homo sapiens_hsa043502.19213816
18Oxidative phosphorylation_Homo sapiens_hsa001902.16599050
19Parkinsons disease_Homo sapiens_hsa050122.08985053
20Vitamin digestion and absorption_Homo sapiens_hsa049772.05907184
21DNA replication_Homo sapiens_hsa030301.96756230
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89017675
23Protein export_Homo sapiens_hsa030601.81911304
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78051837
25Huntingtons disease_Homo sapiens_hsa050161.75232627
26MicroRNAs in cancer_Homo sapiens_hsa052061.74180082
27Axon guidance_Homo sapiens_hsa043601.74085376
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.71246328
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.70108749
30Melanoma_Homo sapiens_hsa052181.70071459
31Steroid biosynthesis_Homo sapiens_hsa001001.67581771
32RNA degradation_Homo sapiens_hsa030181.63379215
33Adherens junction_Homo sapiens_hsa045201.61562287
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60140829
35Basal cell carcinoma_Homo sapiens_hsa052171.60121941
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58578958
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.53729361
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52508802
39Hippo signaling pathway_Homo sapiens_hsa043901.51790771
40Fanconi anemia pathway_Homo sapiens_hsa034601.49047701
41Nucleotide excision repair_Homo sapiens_hsa034201.46459371
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46353912
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.43649318
44cAMP signaling pathway_Homo sapiens_hsa040241.42522517
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40871774
46Glutathione metabolism_Homo sapiens_hsa004801.38253072
47Rap1 signaling pathway_Homo sapiens_hsa040151.37714419
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.37282401
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31928126
50Gap junction_Homo sapiens_hsa045401.29899879
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28271154
52Amoebiasis_Homo sapiens_hsa051461.28158468
53Arachidonic acid metabolism_Homo sapiens_hsa005901.27299594
54Alzheimers disease_Homo sapiens_hsa050101.25779570
55Tight junction_Homo sapiens_hsa045301.25230909
56Pyrimidine metabolism_Homo sapiens_hsa002401.23873608
57Fat digestion and absorption_Homo sapiens_hsa049751.23228343
58Pathways in cancer_Homo sapiens_hsa052001.22983871
59Morphine addiction_Homo sapiens_hsa050321.22586692
60Circadian entrainment_Homo sapiens_hsa047131.21524053
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20992879
62Ras signaling pathway_Homo sapiens_hsa040141.16293796
63Calcium signaling pathway_Homo sapiens_hsa040201.14473687
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12969723
65Sphingolipid metabolism_Homo sapiens_hsa006001.12383186
66Dorso-ventral axis formation_Homo sapiens_hsa043201.07069026
67Protein digestion and absorption_Homo sapiens_hsa049741.06977431
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06715107
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06532641
70Ovarian steroidogenesis_Homo sapiens_hsa049131.06404593
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02844616
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00606722
73Prostate cancer_Homo sapiens_hsa052150.98555552
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98050160
75Cell cycle_Homo sapiens_hsa041100.97674791
76Nitrogen metabolism_Homo sapiens_hsa009100.96954481
77Phototransduction_Homo sapiens_hsa047440.96721701
78Serotonergic synapse_Homo sapiens_hsa047260.95657900
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.94949862
80Oxytocin signaling pathway_Homo sapiens_hsa049210.94807484
81Nicotine addiction_Homo sapiens_hsa050330.94673060
82Taste transduction_Homo sapiens_hsa047420.92996733
83Hedgehog signaling pathway_Homo sapiens_hsa043400.91949744
84African trypanosomiasis_Homo sapiens_hsa051430.87596029
85Spliceosome_Homo sapiens_hsa030400.86913229
86Small cell lung cancer_Homo sapiens_hsa052220.86865198
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86222075
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86173643
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85652361
90Wnt signaling pathway_Homo sapiens_hsa043100.81398826
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81212815
92Chemical carcinogenesis_Homo sapiens_hsa052040.81173660
93MAPK signaling pathway_Homo sapiens_hsa040100.77723820
94Arginine and proline metabolism_Homo sapiens_hsa003300.77545541
95Choline metabolism in cancer_Homo sapiens_hsa052310.77309953
96Base excision repair_Homo sapiens_hsa034100.73733107
97Malaria_Homo sapiens_hsa051440.72524462
98Carbon metabolism_Homo sapiens_hsa012000.72314969
99Mineral absorption_Homo sapiens_hsa049780.72224665
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72164634
101Platelet activation_Homo sapiens_hsa046110.70987301
102Biosynthesis of amino acids_Homo sapiens_hsa012300.70783893
103HTLV-I infection_Homo sapiens_hsa051660.70543996
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69251207
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68773569
106Ether lipid metabolism_Homo sapiens_hsa005650.68466751
107Linoleic acid metabolism_Homo sapiens_hsa005910.68375747
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.68253844
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68093493
110Melanogenesis_Homo sapiens_hsa049160.66658310
111Salivary secretion_Homo sapiens_hsa049700.65370138
112Proteoglycans in cancer_Homo sapiens_hsa052050.63608879
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63422687
114Propanoate metabolism_Homo sapiens_hsa006400.62483923
115Fatty acid elongation_Homo sapiens_hsa000620.61886647
116Cardiac muscle contraction_Homo sapiens_hsa042600.60629763
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.60105600
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59837870
119Long-term depression_Homo sapiens_hsa047300.59118165
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58952661
121GABAergic synapse_Homo sapiens_hsa047270.58897095
122Galactose metabolism_Homo sapiens_hsa000520.57309778
123Sulfur metabolism_Homo sapiens_hsa009200.56990592
124Glutamatergic synapse_Homo sapiens_hsa047240.54705248
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54286834
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54203380
127Homologous recombination_Homo sapiens_hsa034400.52790213
128Renal cell carcinoma_Homo sapiens_hsa052110.52759125
129Phenylalanine metabolism_Homo sapiens_hsa003600.49491598
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49055548
131Metabolic pathways_Homo sapiens_hsa011000.47909011
132Oocyte meiosis_Homo sapiens_hsa041140.47625980
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47252726
134Purine metabolism_Homo sapiens_hsa002300.46761436
135Amphetamine addiction_Homo sapiens_hsa050310.46441034
136Cocaine addiction_Homo sapiens_hsa050300.46411314
137Glioma_Homo sapiens_hsa052140.42730375
138PPAR signaling pathway_Homo sapiens_hsa033200.42255641
139N-Glycan biosynthesis_Homo sapiens_hsa005100.40953939
140p53 signaling pathway_Homo sapiens_hsa041150.39144105
141Estrogen signaling pathway_Homo sapiens_hsa049150.38977681
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38606212
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.38603499
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36833357
145Long-term potentiation_Homo sapiens_hsa047200.36704176
146Pentose phosphate pathway_Homo sapiens_hsa000300.35297912
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34151865
148Herpes simplex infection_Homo sapiens_hsa051680.33828402
149ErbB signaling pathway_Homo sapiens_hsa040120.33098173
150Peroxisome_Homo sapiens_hsa041460.31992864
151Bladder cancer_Homo sapiens_hsa052190.31925967
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.30725682
153Epstein-Barr virus infection_Homo sapiens_hsa051690.29673060
154Pyruvate metabolism_Homo sapiens_hsa006200.27247905
155RNA transport_Homo sapiens_hsa030130.26639105
156Arginine biosynthesis_Homo sapiens_hsa002200.23528005
157Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23380003
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20958336
159Viral carcinogenesis_Homo sapiens_hsa052030.20395685
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20011694
161Thyroid cancer_Homo sapiens_hsa052160.18404893
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18318914
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16376312
164Basal transcription factors_Homo sapiens_hsa030220.15036212

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