GPR21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathway which mobilizes calcium. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.09355154
2nucleobase catabolic process (GO:0046113)5.22626969
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80289306
4neuron cell-cell adhesion (GO:0007158)4.61595527
5synaptic vesicle exocytosis (GO:0016079)4.55824605
6vocalization behavior (GO:0071625)4.54158655
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.43565675
8cell migration in hindbrain (GO:0021535)4.40097685
9regulation of glutamate receptor signaling pathway (GO:1900449)4.36721862
10central nervous system projection neuron axonogenesis (GO:0021952)4.34549759
11positive regulation of cardiac muscle cell differentiation (GO:2000727)4.29142521
12dendrite morphogenesis (GO:0048813)4.24899277
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17504993
14tachykinin receptor signaling pathway (GO:0007217)4.15056775
15glutamate secretion (GO:0014047)4.12648231
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12641220
17protein localization to synapse (GO:0035418)4.08646650
18gamma-aminobutyric acid transport (GO:0015812)4.07030301
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.03888887
20axonal fasciculation (GO:0007413)4.03189488
21neuron recognition (GO:0008038)4.00720831
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.92351804
23axon extension (GO:0048675)3.89385057
24presynaptic membrane assembly (GO:0097105)3.88539505
25regulation of synaptic vesicle exocytosis (GO:2000300)3.81515950
26cerebral cortex radially oriented cell migration (GO:0021799)3.80007451
27layer formation in cerebral cortex (GO:0021819)3.78847833
28protein-cofactor linkage (GO:0018065)3.76535057
29glutamate receptor signaling pathway (GO:0007215)3.75015573
30postsynaptic membrane organization (GO:0001941)3.70214912
31neural tube formation (GO:0001841)3.68920486
32behavioral response to nicotine (GO:0035095)3.61299138
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59892514
34neuronal action potential propagation (GO:0019227)3.58506638
35DNA double-strand break processing (GO:0000729)3.55891008
36proline transport (GO:0015824)3.52678597
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51739285
38neuron-neuron synaptic transmission (GO:0007270)3.49678526
39neuron projection extension (GO:1990138)3.47561845
40locomotory exploration behavior (GO:0035641)3.45971665
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44963833
42central nervous system neuron axonogenesis (GO:0021955)3.43832500
43exploration behavior (GO:0035640)3.42658756
44cAMP catabolic process (GO:0006198)3.42235812
45synaptic transmission, glutamatergic (GO:0035249)3.40303123
46synaptic vesicle endocytosis (GO:0048488)3.38577296
47regulation of synapse maturation (GO:0090128)3.36424147
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36414127
49indolalkylamine metabolic process (GO:0006586)3.35614352
50regulation of synapse structural plasticity (GO:0051823)3.35381908
51presynaptic membrane organization (GO:0097090)3.34667144
52positive regulation of synapse maturation (GO:0090129)3.33504969
53positive regulation of fibroblast migration (GO:0010763)3.31358461
54epithelial cilium movement (GO:0003351)3.30260779
55nonmotile primary cilium assembly (GO:0035058)3.29666606
56protein localization to cilium (GO:0061512)3.27120523
57regulation of sarcomere organization (GO:0060297)3.25616961
58protein polyglutamylation (GO:0018095)3.25368578
59synaptic vesicle maturation (GO:0016188)3.24521699
60adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.24031167
61neurotransmitter-gated ion channel clustering (GO:0072578)3.22380149
62regulation of synaptic vesicle transport (GO:1902803)3.20802274
63negative regulation of microtubule polymerization (GO:0031115)3.19587399
64detection of light stimulus involved in visual perception (GO:0050908)3.18982905
65detection of light stimulus involved in sensory perception (GO:0050962)3.18982905
66cerebellar granule cell differentiation (GO:0021707)3.18910299
67cilium morphogenesis (GO:0060271)3.17613640
68detection of calcium ion (GO:0005513)3.17175771
69dendrite development (GO:0016358)3.16260142
70neurotransmitter secretion (GO:0007269)3.15569629
71regulation of development, heterochronic (GO:0040034)3.15053765
72regulation of timing of cell differentiation (GO:0048505)3.14319623
73adaptation of signaling pathway (GO:0023058)3.10026131
74establishment of nucleus localization (GO:0040023)3.09011785
75regulation of glutamate secretion (GO:0014048)3.08641014
76organelle transport along microtubule (GO:0072384)3.07569644
77dendritic spine morphogenesis (GO:0060997)3.06229120
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05854564
79positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.05674055
80behavioral response to ethanol (GO:0048149)3.05128598
81regulation of cilium movement (GO:0003352)3.05036976
82inositol phosphate catabolic process (GO:0071545)3.04927110
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04725304
84negative regulation of dendrite development (GO:2000171)3.03136155
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02929767
86sialylation (GO:0097503)3.02740904
87regulation of neurotransmitter secretion (GO:0046928)3.00848448
88regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00189742
89dopamine receptor signaling pathway (GO:0007212)2.99884975
90startle response (GO:0001964)2.99443901
91vesicle transport along microtubule (GO:0047496)2.97991660
92cyclic nucleotide catabolic process (GO:0009214)2.97798560
93clathrin coat assembly (GO:0048268)2.97673399
94hippocampus development (GO:0021766)2.97438282
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95923021
96regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95108799
97cerebellar Purkinje cell differentiation (GO:0021702)2.94379127
98interkinetic nuclear migration (GO:0022027)2.93411774
99negative regulation of neurotransmitter transport (GO:0051589)2.90601271
100regulation of postsynaptic membrane potential (GO:0060078)2.90481346
101long-term synaptic potentiation (GO:0060291)2.87970570
102retinal cone cell development (GO:0046549)2.86445033
103cilium or flagellum-dependent cell motility (GO:0001539)2.85344933
104response to parathyroid hormone (GO:0071107)2.85244034
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82799602
106mechanosensory behavior (GO:0007638)2.82123135
107cilium movement (GO:0003341)2.80525879
108kynurenine metabolic process (GO:0070189)2.80004531
109glycine transport (GO:0015816)2.79671112
110serotonin metabolic process (GO:0042428)2.79263625
111opioid receptor signaling pathway (GO:0038003)2.77397884
112cerebellum development (GO:0021549)2.76820220
113photoreceptor cell development (GO:0042461)2.76421167
114synapse assembly (GO:0007416)2.76027435
115behavioral fear response (GO:0001662)2.75952337
116behavioral defense response (GO:0002209)2.75952337
117cellular ketone body metabolic process (GO:0046950)2.75321205
118inner ear receptor stereocilium organization (GO:0060122)2.74342456
119regulation of neuronal synaptic plasticity (GO:0048168)2.72130689
120glycosphingolipid biosynthetic process (GO:0006688)2.71875263
121L-fucose catabolic process (GO:0042355)2.70876720
122fucose catabolic process (GO:0019317)2.70876720
123L-fucose metabolic process (GO:0042354)2.70876720
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.70623117
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70576086
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70464852
127positive regulation of filopodium assembly (GO:0051491)2.70327505
128neuron migration (GO:0001764)2.69899765
129positive regulation of synapse assembly (GO:0051965)2.69571268
130indolalkylamine catabolic process (GO:0046218)2.69256098
131tryptophan catabolic process (GO:0006569)2.69256098
132indole-containing compound catabolic process (GO:0042436)2.69256098
133L-amino acid import (GO:0043092)2.69208826
134neuromuscular synaptic transmission (GO:0007274)2.69125529
135regulation of cardiac muscle cell differentiation (GO:2000725)2.68922116
136eye photoreceptor cell development (GO:0042462)2.66235245
137cellular response to prostaglandin stimulus (GO:0071379)2.65026178
138transmission of nerve impulse (GO:0019226)2.64599725
139regulation of neurotransmitter transport (GO:0051588)2.64449962
140urinary tract smooth muscle contraction (GO:0014848)2.63585856
141regulation of synaptic transmission, glutamatergic (GO:0051966)2.63207849
142cellular response to interleukin-15 (GO:0071350)2.63144941
143negative regulation of systemic arterial blood pressure (GO:0003085)2.62710928
144auditory behavior (GO:0031223)2.61155281
145regulation of heat generation (GO:0031650)2.60680255
146platelet dense granule organization (GO:0060155)2.60311375
147parental behavior (GO:0060746)2.59471248
148C4-dicarboxylate transport (GO:0015740)2.58781445
149acrosome reaction (GO:0007340)2.58302836
150positive regulation of amino acid transport (GO:0051957)2.57592172
151serotonin receptor signaling pathway (GO:0007210)2.55325326
152response to pheromone (GO:0019236)2.55309385
153regulation of pigment cell differentiation (GO:0050932)2.54894888
154reflex (GO:0060004)2.54775155
155tryptophan metabolic process (GO:0006568)2.52960889
156regulation of feeding behavior (GO:0060259)2.52344814
157detection of mechanical stimulus involved in sensory perception (GO:0050974)2.51998295
158indole-containing compound metabolic process (GO:0042430)2.50579048
159photoreceptor cell maintenance (GO:0045494)2.50539719
160regulation of collateral sprouting (GO:0048670)2.49041665
161cilium organization (GO:0044782)2.47977224
162aggressive behavior (GO:0002118)2.46252200
163epithelial cell differentiation involved in kidney development (GO:0035850)2.45746814
164DNA methylation involved in gamete generation (GO:0043046)2.45445680
165tyrosine phosphorylation of STAT protein (GO:0007260)2.44944116
166epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44164656
167calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43215471
168axoneme assembly (GO:0035082)2.42991543
169brain morphogenesis (GO:0048854)2.42275533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79821817
2GBX2_23144817_ChIP-Seq_PC3_Human4.25226505
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.29533065
4ZNF274_21170338_ChIP-Seq_K562_Hela3.14448188
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.74560037
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65790649
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53681178
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45330697
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40082491
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36654242
11TAF15_26573619_Chip-Seq_HEK293_Human2.36155101
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28005667
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25144734
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19695662
15REST_21632747_ChIP-Seq_MESCs_Mouse2.16085857
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14896852
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11416267
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11234299
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09762030
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.03312632
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97852246
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97852246
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96652876
24P300_19829295_ChIP-Seq_ESCs_Human1.92808852
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91690109
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89690161
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89014397
28FUS_26573619_Chip-Seq_HEK293_Human1.88552360
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87957100
30SMAD4_21799915_ChIP-Seq_A2780_Human1.85431439
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84953505
32AR_21572438_ChIP-Seq_LNCaP_Human1.82131259
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.80132283
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79053133
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78233453
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76747641
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76190782
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71882679
39CBP_20019798_ChIP-Seq_JUKART_Human1.71882679
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.71560242
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70347858
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.69214526
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.67927978
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.67674272
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.65528294
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62926463
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62111056
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.61640207
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61518832
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.61053039
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59439389
52AR_25329375_ChIP-Seq_VCAP_Human1.58001896
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57516454
54DROSHA_22980978_ChIP-Seq_HELA_Human1.56516671
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55475916
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54871154
57AHR_22903824_ChIP-Seq_MCF-7_Human1.54289169
58STAT3_23295773_ChIP-Seq_U87_Human1.53634238
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.52899891
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.50665134
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50532368
62IGF1R_20145208_ChIP-Seq_DFB_Human1.48403995
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45066443
64TCF4_23295773_ChIP-Seq_U87_Human1.42955611
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.42328939
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42174718
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.40837790
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40541098
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40237859
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38450132
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38354293
72ER_23166858_ChIP-Seq_MCF-7_Human1.38332733
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.37038574
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.36460105
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35083346
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.31754898
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.31619032
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31210934
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30784487
80TP53_18474530_ChIP-ChIP_U2OS_Human1.30419726
81TP53_22573176_ChIP-Seq_HFKS_Human1.29677188
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28868864
83RNF2_27304074_Chip-Seq_NSC_Mouse1.28022440
84TCF4_22108803_ChIP-Seq_LS180_Human1.27856350
85* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27521752
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25721092
87RUNX2_22187159_ChIP-Seq_PCA_Human1.24418891
88* E2F1_18555785_Chip-Seq_ESCs_Mouse1.24052536
89BCAT_22108803_ChIP-Seq_LS180_Human1.23737405
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.23442633
91EWS_26573619_Chip-Seq_HEK293_Human1.22491706
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21954155
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21018006
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20838045
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20838045
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19935463
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15997055
98* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15513998
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.15178770
100* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14984319
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14840998
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14418582
103NANOG_19829295_ChIP-Seq_ESCs_Human1.13844715
104SOX2_19829295_ChIP-Seq_ESCs_Human1.13844715
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13277336
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12458248
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10832368
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.10589612
109AR_19668381_ChIP-Seq_PC3_Human1.10066307
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09793333
111VDR_22108803_ChIP-Seq_LS180_Human1.09437964
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09373556
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.09170530
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09155758
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.08734194
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.07185551
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07147700
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.06953745
119JUN_21703547_ChIP-Seq_K562_Human1.06738719
120CDX2_22108803_ChIP-Seq_LS180_Human1.05659881
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05433542
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05391749
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04580474
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03669038
125* P300_18555785_Chip-Seq_ESCs_Mouse1.03395138
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03354706
127KDM2B_26808549_Chip-Seq_REH_Human1.03266515
128* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01065049
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.00732311
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00574139
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00533666
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99793649
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99376319
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.98069311
135* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96378579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.89263486
2MP0000569_abnormal_digit_pigmentation3.86223263
3MP0003635_abnormal_synaptic_transmissio3.56938562
4MP0004270_analgesia3.46361774
5MP0002063_abnormal_learning/memory/cond3.22411341
6MP0000778_abnormal_nervous_system3.12530360
7MP0003787_abnormal_imprinting3.04366084
8MP0009745_abnormal_behavioral_response2.96649038
9MP0003880_abnormal_central_pattern2.93945015
10MP0002653_abnormal_ependyma_morphology2.77904694
11MP0001968_abnormal_touch/_nociception2.69804792
12MP0002572_abnormal_emotion/affect_behav2.67343840
13MP0005645_abnormal_hypothalamus_physiol2.52407026
14MP0002064_seizures2.51632994
15MP0002734_abnormal_mechanical_nocicepti2.47225186
16MP0001486_abnormal_startle_reflex2.40111166
17MP0002184_abnormal_innervation2.37225524
18MP0001440_abnormal_grooming_behavior2.31663601
19MP0002102_abnormal_ear_morphology2.30021967
20MP0002736_abnormal_nociception_after2.23682975
21MP0001188_hyperpigmentation2.20182048
22MP0009046_muscle_twitch2.19496062
23MP0002163_abnormal_gland_morphology2.17852546
24MP0002557_abnormal_social/conspecific_i2.03571930
25MP0010368_abnormal_lymphatic_system2.03005815
26MP0002067_abnormal_sensory_capabilities2.02632748
27MP0003121_genomic_imprinting2.01164321
28MP0004147_increased_porphyrin_level2.01156736
29MP0001501_abnormal_sleep_pattern1.96273778
30MP0005386_behavior/neurological_phenoty1.93914616
31MP0004924_abnormal_behavior1.93914616
32MP0005253_abnormal_eye_physiology1.93682893
33MP0002822_catalepsy1.91156193
34MP0006276_abnormal_autonomic_nervous1.85668465
35MP0009780_abnormal_chondrocyte_physiolo1.83274102
36MP0005379_endocrine/exocrine_gland_phen1.82562392
37MP0005423_abnormal_somatic_nervous1.81011374
38MP0002733_abnormal_thermal_nociception1.81005134
39MP0005171_absent_coat_pigmentation1.79094321
40MP0005084_abnormal_gallbladder_morpholo1.78802510
41MP0008872_abnormal_physiological_respon1.78183511
42MP0004811_abnormal_neuron_physiology1.73679512
43MP0003122_maternal_imprinting1.73109610
44MP0002272_abnormal_nervous_system1.70496190
45MP0003011_delayed_dark_adaptation1.67527148
46MP0002735_abnormal_chemical_nociception1.67229518
47MP0002928_abnormal_bile_duct1.65292112
48MP0005499_abnormal_olfactory_system1.61942062
49MP0005394_taste/olfaction_phenotype1.61942062
50MP0001970_abnormal_pain_threshold1.61027857
51MP0003879_abnormal_hair_cell1.58380045
52MP0004215_abnormal_myocardial_fiber1.53399067
53MP0008877_abnormal_DNA_methylation1.52217642
54MP0004858_abnormal_nervous_system1.51181741
55MP0000955_abnormal_spinal_cord1.49023274
56MP0003183_abnormal_peptide_metabolism1.44497210
57MP0002882_abnormal_neuron_morphology1.43855587
58MP0004142_abnormal_muscle_tone1.43431663
59MP0003890_abnormal_embryonic-extraembry1.43126960
60MP0010386_abnormal_urinary_bladder1.40888760
61MP0000015_abnormal_ear_pigmentation1.35380622
62MP0006292_abnormal_olfactory_placode1.32032086
63MP0002152_abnormal_brain_morphology1.26676204
64MP0001984_abnormal_olfaction1.26465465
65MP0002638_abnormal_pupillary_reflex1.24776366
66MP0005248_abnormal_Harderian_gland1.24272778
67MP0005646_abnormal_pituitary_gland1.22813046
68MP0002277_abnormal_respiratory_mucosa1.22750962
69MP0002160_abnormal_reproductive_system1.22305700
70MP0002234_abnormal_pharynx_morphology1.22092470
71MP0002066_abnormal_motor_capabilities/c1.20769277
72MP0008569_lethality_at_weaning1.20428781
73MP0008789_abnormal_olfactory_epithelium1.20054649
74MP0000631_abnormal_neuroendocrine_gland1.12076094
75MP0000516_abnormal_urinary_system1.09487234
76MP0005367_renal/urinary_system_phenotyp1.09487234
77MP0002876_abnormal_thyroid_physiology1.08850349
78MP0003195_calcinosis1.07892450
79MP0004043_abnormal_pH_regulation1.07569483
80MP0005187_abnormal_penis_morphology1.06430755
81MP0004134_abnormal_chest_morphology1.05461922
82MP0003943_abnormal_hepatobiliary_system1.03796435
83MP0004133_heterotaxia1.00226624
84MP0008875_abnormal_xenobiotic_pharmacok0.99422040
85MP0003646_muscle_fatigue0.98217807
86MP0001177_atelectasis0.97202865
87MP0003861_abnormal_nervous_system0.96611291
88MP0005389_reproductive_system_phenotype0.96390064
89MP0001502_abnormal_circadian_rhythm0.93906634
90MP0000372_irregular_coat_pigmentation0.93776160
91MP0001879_abnormal_lymphatic_vessel0.92596919
92MP0000751_myopathy0.91681178
93MP0006072_abnormal_retinal_apoptosis0.91591454
94MP0004085_abnormal_heartbeat0.91213383
95MP0002751_abnormal_autonomic_nervous0.88016409
96MP0002909_abnormal_adrenal_gland0.87799735
97MP0002752_abnormal_somatic_nervous0.84865171
98MP0008995_early_reproductive_senescence0.84477260
99MP0002229_neurodegeneration0.84423133
100MP0004742_abnormal_vestibular_system0.83096136
101MP0001986_abnormal_taste_sensitivity0.79802949
102MP0002069_abnormal_eating/drinking_beha0.79721958
103MP0001529_abnormal_vocalization0.79619104
104MP0005195_abnormal_posterior_eye0.78999837
105MP0004484_altered_response_of0.78441223
106MP0008058_abnormal_DNA_repair0.77850786
107MP0003698_abnormal_male_reproductive0.77433023
108MP0003119_abnormal_digestive_system0.77273639
109MP0005409_darkened_coat_color0.75546331
110MP0004885_abnormal_endolymph0.75527205
111MP0001963_abnormal_hearing_physiology0.74724904
112MP0000465_gastrointestinal_hemorrhage0.74157034
113MP0003718_maternal_effect0.73557142
114MP0000026_abnormal_inner_ear0.72580575
115MP0001905_abnormal_dopamine_level0.72403425
116MP0001764_abnormal_homeostasis0.72111155
117MP0003633_abnormal_nervous_system0.70992718
118MP0005174_abnormal_tail_pigmentation0.69848431
119MP0003631_nervous_system_phenotype0.69153320
120MP0003137_abnormal_impulse_conducting0.68015240
121MP0003385_abnormal_body_wall0.67603811
122MP0002082_postnatal_lethality0.67504992
123MP0010770_preweaning_lethality0.67504992
124MP0003755_abnormal_palate_morphology0.67268220
125MP0002081_perinatal_lethality0.64317773
126MP0010769_abnormal_survival0.62661887
127MP0005551_abnormal_eye_electrophysiolog0.62314294
128MP0010768_mortality/aging0.59303551
129MP0000427_abnormal_hair_cycle0.59163170
130MP0001299_abnormal_eye_distance/0.57136841
131MP0000538_abnormal_urinary_bladder0.56717693
132MP0002837_dystrophic_cardiac_calcinosis0.54389392
133MP0003136_yellow_coat_color0.53716705
134MP0002095_abnormal_skin_pigmentation0.53013432

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.62710007
2Protruding tongue (HP:0010808)4.35441184
3Focal seizures (HP:0007359)4.24862127
4Pancreatic fibrosis (HP:0100732)4.13871298
5Epileptic encephalopathy (HP:0200134)4.09281698
6Pancreatic cysts (HP:0001737)4.02015475
7True hermaphroditism (HP:0010459)3.93957434
8Drooling (HP:0002307)3.89822140
9Excessive salivation (HP:0003781)3.89822140
10Febrile seizures (HP:0002373)3.82514918
11Medial flaring of the eyebrow (HP:0010747)3.64519443
12Broad-based gait (HP:0002136)3.48333601
13Abnormality of midbrain morphology (HP:0002418)3.42807719
14Molar tooth sign on MRI (HP:0002419)3.42807719
15Hyperventilation (HP:0002883)3.30270991
16Abnormality of the labia minora (HP:0012880)3.29226229
17Visual hallucinations (HP:0002367)3.27889876
18Progressive cerebellar ataxia (HP:0002073)3.23193596
19Inappropriate behavior (HP:0000719)3.22716677
20Myokymia (HP:0002411)3.13115690
21Congenital primary aphakia (HP:0007707)3.06867233
22Sleep apnea (HP:0010535)3.05568691
23Abnormality of the corticospinal tract (HP:0002492)2.98713652
24Absent speech (HP:0001344)2.98194876
25Blue irides (HP:0000635)2.90386509
26Exotropia (HP:0000577)2.86390642
27Abnormal hair whorl (HP:0010721)2.84994352
28Nephrogenic diabetes insipidus (HP:0009806)2.82194707
29Epileptiform EEG discharges (HP:0011182)2.78028878
30Atonic seizures (HP:0010819)2.77076454
31Generalized tonic-clonic seizures (HP:0002069)2.75774338
32Fair hair (HP:0002286)2.75245203
33Absence seizures (HP:0002121)2.71871262
34Polyphagia (HP:0002591)2.68644471
35Attenuation of retinal blood vessels (HP:0007843)2.65821171
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65428007
37Hepatoblastoma (HP:0002884)2.65160358
38Dialeptic seizures (HP:0011146)2.65109076
39EEG with generalized epileptiform discharges (HP:0011198)2.63050348
40Abnormality of salivation (HP:0100755)2.61124346
41Generalized hypopigmentation of hair (HP:0011358)2.60401379
42Cystic liver disease (HP:0006706)2.60204202
43Genital tract atresia (HP:0001827)2.59887120
44Poor eye contact (HP:0000817)2.57352595
45Vaginal atresia (HP:0000148)2.56313999
46Aqueductal stenosis (HP:0002410)2.52073194
47Abnormality of binocular vision (HP:0011514)2.51715890
48Diplopia (HP:0000651)2.51715890
49Chronic diarrhea (HP:0002028)2.51308168
50Abolished electroretinogram (ERG) (HP:0000550)2.48809488
51Akinesia (HP:0002304)2.47987358
52Nephronophthisis (HP:0000090)2.47890990
53Lissencephaly (HP:0001339)2.46926087
54Abnormality of the renal cortex (HP:0011035)2.45505207
55Stereotypic behavior (HP:0000733)2.45497206
56Oligodactyly (hands) (HP:0001180)2.43077633
57Diastasis recti (HP:0001540)2.41486892
58Abnormal rod and cone electroretinograms (HP:0008323)2.41218898
59Impaired vibration sensation in the lower limbs (HP:0002166)2.40490164
60Hypsarrhythmia (HP:0002521)2.40257998
61Genetic anticipation (HP:0003743)2.40196869
62Failure to thrive in infancy (HP:0001531)2.39402887
63Anencephaly (HP:0002323)2.38816175
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.38811116
65Short 4th metacarpal (HP:0010044)2.38811116
66Keratoconus (HP:0000563)2.37942907
67Increased corneal curvature (HP:0100692)2.37942907
68Amyotrophic lateral sclerosis (HP:0007354)2.36283470
69Aplasia/Hypoplasia of the brainstem (HP:0007362)2.35403026
70Hypoplasia of the brainstem (HP:0002365)2.35403026
71Inability to walk (HP:0002540)2.34541555
72Abnormality of the renal medulla (HP:0100957)2.33945555
73Decreased central vision (HP:0007663)2.32164373
74Congenital hepatic fibrosis (HP:0002612)2.27769045
75Postaxial foot polydactyly (HP:0001830)2.26911205
76Agitation (HP:0000713)2.25637230
77Papillary thyroid carcinoma (HP:0002895)2.25401497
78Heterochromia iridis (HP:0001100)2.25025631
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.23449738
80Tubular atrophy (HP:0000092)2.23244051
81Progressive inability to walk (HP:0002505)2.23167128
82Amblyopia (HP:0000646)2.22561038
83Type I transferrin isoform profile (HP:0003642)2.18146599
84Tented upper lip vermilion (HP:0010804)2.17840189
85Pendular nystagmus (HP:0012043)2.16676698
86Cortical dysplasia (HP:0002539)2.16646987
87Rhinitis (HP:0012384)2.16460762
88Incomplete penetrance (HP:0003829)2.15350543
89Abnormal social behavior (HP:0012433)2.12993272
90Impaired social interactions (HP:0000735)2.12993272
91Abnormal protein glycosylation (HP:0012346)2.12061864
92Abnormal glycosylation (HP:0012345)2.12061864
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12061864
94Abnormal protein N-linked glycosylation (HP:0012347)2.12061864
95Pachygyria (HP:0001302)2.11017644
96Abnormal biliary tract physiology (HP:0012439)2.10908322
97Bile duct proliferation (HP:0001408)2.10908322
98Poor coordination (HP:0002370)2.09501718
99Termporal pattern (HP:0011008)2.09092695
100Insidious onset (HP:0003587)2.09092695
101Split foot (HP:0001839)2.06271292
102Urinary bladder sphincter dysfunction (HP:0002839)2.06117065
103Degeneration of the lateral corticospinal tracts (HP:0002314)2.05425821
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05425821
105Abnormality of the nasal septum (HP:0000419)2.05196269
106Absent eyebrow (HP:0002223)2.04495207
107Congenital stationary night blindness (HP:0007642)2.04467054
108Mutism (HP:0002300)2.03883915
109Abnormal drinking behavior (HP:0030082)2.03105322
110Polydipsia (HP:0001959)2.03105322
111Ankle clonus (HP:0011448)2.02367621
112Abnormal eating behavior (HP:0100738)2.01570019
113Urinary urgency (HP:0000012)2.01350509
114Lower limb amyotrophy (HP:0007210)2.01075827
115Dyskinesia (HP:0100660)2.00126066
116Postaxial hand polydactyly (HP:0001162)1.99808009
117Narrow forehead (HP:0000341)1.98518031
118Abnormality of macular pigmentation (HP:0008002)1.95998364
119Neonatal respiratory distress (HP:0002643)1.93736528
120Short foot (HP:0001773)1.93651468
121Poor suck (HP:0002033)1.93273949
122Midline defect of the nose (HP:0004122)1.92624537
123Recurrent sinusitis (HP:0011108)1.92034261
124Absent hand (HP:0004050)1.91876124
125Progressive sensorineural hearing impairment (HP:0000408)1.91746554
126Generalized hypotonia (HP:0001290)1.90821160
127Opisthotonus (HP:0002179)1.90779773
128Occipital encephalocele (HP:0002085)1.90484262
129Thyroiditis (HP:0100646)1.90357713
130Gait imbalance (HP:0002141)1.90293351
131Specific learning disability (HP:0001328)1.89404943
132Small hand (HP:0200055)1.89367994
133Chronic hepatic failure (HP:0100626)1.89335549
134Sclerocornea (HP:0000647)1.89192096
135Anxiety (HP:0000739)1.88210884
136Astigmatism (HP:0000483)1.87556916
137Tubulointerstitial nephritis (HP:0001970)1.86598674
138Hypoproteinemia (HP:0003075)1.85795115
139Widely spaced teeth (HP:0000687)1.85527299
140Heterotopia (HP:0002282)1.84860607
141Optic disc pallor (HP:0000543)1.84577736
142Depression (HP:0000716)1.83625078
143Abnormal ciliary motility (HP:0012262)1.83611568
144Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83400075
145Intellectual disability, moderate (HP:0002342)1.82690470
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.82252222
147Supernumerary spleens (HP:0009799)1.82200406
148Autism (HP:0000717)1.82112287
149Spastic tetraplegia (HP:0002510)1.81510640
150Type II lissencephaly (HP:0007260)1.81221062
151Furrowed tongue (HP:0000221)1.81130225
152Hemiparesis (HP:0001269)1.80917226
153Palpebral edema (HP:0100540)1.80426313
154Aplasia/Hypoplasia of the lens (HP:0008063)1.78303372
155Growth hormone deficiency (HP:0000824)1.77881319
156Limb dystonia (HP:0002451)1.76409050
157Supranuclear gaze palsy (HP:0000605)1.76399787
158Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75553919
159Hypoplasia of the corpus callosum (HP:0002079)1.75295295
160Deeply set eye (HP:0000490)1.74878591
161Abnormal respiratory motile cilium physiology (HP:0012261)1.74784091
162Shoulder girdle muscle weakness (HP:0003547)1.74380166
163Oligodactyly (HP:0012165)1.73764650
164Rimmed vacuoles (HP:0003805)1.73679960
165Renal cortical cysts (HP:0000803)1.72345986
166Hypokalemic alkalosis (HP:0001949)1.72088279
167Sporadic (HP:0003745)1.71696919
168Truncal ataxia (HP:0002078)1.71486691
169Gaze-evoked nystagmus (HP:0000640)1.71288484
170Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70702782
171Gastroesophageal reflux (HP:0002020)1.68758721
172Torticollis (HP:0000473)1.67859960
173Absent frontal sinuses (HP:0002688)1.66570825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.04898161
2CASK4.30744456
3PDK24.19947450
4MAP2K73.75308359
5MAP3K43.63484511
6MAPK133.09920533
7TRIM283.08119232
8MAP4K23.07798878
9TIE12.36652963
10MAP3K92.34729446
11NTRK32.29215098
12MAP3K122.13307738
13MINK12.09528349
14PLK22.00696199
15MAP2K41.99780936
16DAPK21.86457246
17STK38L1.86083312
18MAP3K61.80863968
19SIK31.80577844
20ERBB31.72952040
21ZAK1.71212606
22KSR11.71081229
23SGK21.71061476
24RIPK41.63541016
25DYRK21.63264357
26PINK11.62358976
27EPHA41.62011432
28CDK191.56977066
29NTRK21.55972484
30SIK21.55046704
31EPHA31.54123133
32LATS11.52325180
33CSNK1G11.49320184
34TNIK1.39099257
35BMPR21.29796856
36AKT31.27539390
37SGK4941.26499106
38SGK2231.26499106
39BMPR1B1.24187164
40PRKD31.22753337
41SGK31.14285012
42PRPF4B1.11883426
43TAOK31.07815423
44WNK31.07060578
45BCR1.05804635
46CAMK1G1.04321614
47PRKCG1.03273689
48PAK61.02471618
49CDK51.01928442
50DYRK1A0.99963455
51IRAK10.97982494
52MAPK70.97170842
53CAMK40.95604544
54PHKG20.95243554
55PHKG10.95243554
56BRD40.93153781
57CSNK1G20.90374261
58PNCK0.84447803
59WNK40.83777856
60DAPK10.83225862
61EIF2AK30.81937685
62UHMK10.81706475
63NEK60.79389241
64CCNB10.78488844
65MKNK20.77288768
66BCKDK0.77059199
67CAMK1D0.76157550
68FRK0.75319725
69MARK20.75104722
70TEC0.74206885
71TXK0.73504079
72GRK10.73348238
73PTK2B0.72776620
74MATK0.72756404
75KIT0.70188966
76CAMK2A0.69738295
77YES10.68802374
78VRK10.67721132
79PRKCE0.66906734
80SGK10.66475183
81CDK180.65640296
82OXSR10.65622760
83PRKCZ0.65427331
84ADRBK10.65043002
85FGFR20.63895975
86CDK30.62804261
87EPHB20.62470342
88STK390.61019692
89EIF2AK20.60289120
90FES0.60157937
91DMPK0.58074677
92PRKACA0.56770453
93TSSK60.56624868
94GRK50.56485630
95ACVR1B0.55797047
96CAMKK20.55171469
97CDK150.53120710
98MAP3K70.52897394
99RPS6KA40.52351659
100RET0.52148617
101PKN10.51857583
102LATS20.50725364
103MAP3K50.50717460
104CAMKK10.50285441
105CDK80.50241799
106FER0.50044707
107CDK140.48972350
108FGR0.46980643
109CSNK1D0.46489929
110PRKG10.45881557
111CSNK1A1L0.44862582
112STK110.44804850
113MAPKAPK30.44429366
114CSNK1A10.43532804
115RPS6KA20.43395735
116OBSCN0.42495361
117CAMK10.42109396
118INSRR0.41740618
119MAPK80.40531058
120IGF1R0.40502824
121FGFR30.39507201
122CAMK2D0.39384993
123BRAF0.38952530
124NLK0.38906879
125CDK11A0.38700962
126PRKCQ0.38415405
127PRKAA20.38302298
128TYRO30.37401172
129FLT30.36747339
130PRKCB0.36738525
131STK30.36392908
132CSNK1G30.35789960
133PRKACG0.35694193
134TGFBR10.35630309
135ADRBK20.33512145
136ROCK10.32531297
137ABL10.32318245
138CAMK2G0.31102980
139PRKCA0.30848511
140LIMK10.30258125
141MAPK120.29745763
142MAPK90.29665396
143CAMK2B0.29377995
144NUAK10.28871801
145PAK30.28791871

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.86515140
2Nicotine addiction_Homo sapiens_hsa050333.36411956
3Synaptic vesicle cycle_Homo sapiens_hsa047213.06796327
4Butanoate metabolism_Homo sapiens_hsa006502.81952868
5Circadian entrainment_Homo sapiens_hsa047132.49059536
6Morphine addiction_Homo sapiens_hsa050322.47566642
7Olfactory transduction_Homo sapiens_hsa047402.38972107
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30514591
9Glutamatergic synapse_Homo sapiens_hsa047242.15617839
10Long-term potentiation_Homo sapiens_hsa047202.11620160
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99545221
12Collecting duct acid secretion_Homo sapiens_hsa049661.98383965
13GABAergic synapse_Homo sapiens_hsa047271.97186124
14Dopaminergic synapse_Homo sapiens_hsa047281.96192025
15Axon guidance_Homo sapiens_hsa043601.91232499
16Cholinergic synapse_Homo sapiens_hsa047251.88868308
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74194739
18Caffeine metabolism_Homo sapiens_hsa002321.73665993
19Amphetamine addiction_Homo sapiens_hsa050311.61383486
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.61224020
21Long-term depression_Homo sapiens_hsa047301.57858440
22Renin secretion_Homo sapiens_hsa049241.57358275
23Serotonergic synapse_Homo sapiens_hsa047261.57025405
24Insulin secretion_Homo sapiens_hsa049111.53067178
25Linoleic acid metabolism_Homo sapiens_hsa005911.51191812
26ErbB signaling pathway_Homo sapiens_hsa040121.50785921
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46741468
28Salivary secretion_Homo sapiens_hsa049701.45814874
29Nitrogen metabolism_Homo sapiens_hsa009101.44536511
30Calcium signaling pathway_Homo sapiens_hsa040201.30290751
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28415381
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25766621
33Gap junction_Homo sapiens_hsa045401.25224415
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25059758
35Oxytocin signaling pathway_Homo sapiens_hsa049211.22771196
36Colorectal cancer_Homo sapiens_hsa052101.22625877
37Tryptophan metabolism_Homo sapiens_hsa003801.20792033
38Vibrio cholerae infection_Homo sapiens_hsa051101.20736387
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20609407
40Type II diabetes mellitus_Homo sapiens_hsa049301.19180909
41Basal transcription factors_Homo sapiens_hsa030221.18798601
42Oxidative phosphorylation_Homo sapiens_hsa001901.18679641
43Endometrial cancer_Homo sapiens_hsa052131.17912305
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17445828
45Glioma_Homo sapiens_hsa052141.17353405
46Regulation of autophagy_Homo sapiens_hsa041401.17113741
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16782184
48cAMP signaling pathway_Homo sapiens_hsa040241.16776857
49Taste transduction_Homo sapiens_hsa047421.16026181
50Fanconi anemia pathway_Homo sapiens_hsa034601.13536510
51Phototransduction_Homo sapiens_hsa047441.13519796
52Ether lipid metabolism_Homo sapiens_hsa005651.11794004
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.07430989
54GnRH signaling pathway_Homo sapiens_hsa049121.06927185
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05438631
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03215539
57Parkinsons disease_Homo sapiens_hsa050121.01761086
58beta-Alanine metabolism_Homo sapiens_hsa004101.01345691
59Sulfur relay system_Homo sapiens_hsa041221.01068479
60Phagosome_Homo sapiens_hsa041451.00443657
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00413611
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99709983
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99146474
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98692700
65Gastric acid secretion_Homo sapiens_hsa049710.98513785
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96231422
67RNA polymerase_Homo sapiens_hsa030200.95832940
68Fatty acid biosynthesis_Homo sapiens_hsa000610.95560833
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94536467
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94119956
71Cocaine addiction_Homo sapiens_hsa050300.93551553
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.92024376
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91674956
74Estrogen signaling pathway_Homo sapiens_hsa049150.91208777
75MAPK signaling pathway_Homo sapiens_hsa040100.91008422
76Peroxisome_Homo sapiens_hsa041460.89579297
77Melanogenesis_Homo sapiens_hsa049160.89578670
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89539551
79Dorso-ventral axis formation_Homo sapiens_hsa043200.87291877
80Circadian rhythm_Homo sapiens_hsa047100.86104401
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83818125
82Arachidonic acid metabolism_Homo sapiens_hsa005900.82457391
83Protein export_Homo sapiens_hsa030600.82409884
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.82397228
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82366485
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81042704
87Alcoholism_Homo sapiens_hsa050340.80784951
88Ras signaling pathway_Homo sapiens_hsa040140.80567986
89Selenocompound metabolism_Homo sapiens_hsa004500.79733521
90Propanoate metabolism_Homo sapiens_hsa006400.77777107
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77768863
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76090794
93Primary immunodeficiency_Homo sapiens_hsa053400.74401695
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.74297616
95Viral myocarditis_Homo sapiens_hsa054160.74209239
96Rheumatoid arthritis_Homo sapiens_hsa053230.73722246
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73175814
98Wnt signaling pathway_Homo sapiens_hsa043100.71340186
99Renal cell carcinoma_Homo sapiens_hsa052110.71054384
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70338387
101Pancreatic cancer_Homo sapiens_hsa052120.69988089
102Non-small cell lung cancer_Homo sapiens_hsa052230.68521273
103Chemokine signaling pathway_Homo sapiens_hsa040620.66581631
104Rap1 signaling pathway_Homo sapiens_hsa040150.66201185
105Dilated cardiomyopathy_Homo sapiens_hsa054140.65561126
106Oocyte meiosis_Homo sapiens_hsa041140.64592790
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64440770
108Hedgehog signaling pathway_Homo sapiens_hsa043400.64114218
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64026762
110Glycerolipid metabolism_Homo sapiens_hsa005610.63649665
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62575422
112Choline metabolism in cancer_Homo sapiens_hsa052310.62515967
113Chemical carcinogenesis_Homo sapiens_hsa052040.60978935
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.60325894
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60210671
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59794850
117Huntingtons disease_Homo sapiens_hsa050160.59656458
118Cardiac muscle contraction_Homo sapiens_hsa042600.59580692
119mRNA surveillance pathway_Homo sapiens_hsa030150.59425544
120Prolactin signaling pathway_Homo sapiens_hsa049170.59293352
121Melanoma_Homo sapiens_hsa052180.57889308
122Inositol phosphate metabolism_Homo sapiens_hsa005620.57705982
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56293741
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55948459
125African trypanosomiasis_Homo sapiens_hsa051430.55844176
126RNA degradation_Homo sapiens_hsa030180.55784391
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55187806
128FoxO signaling pathway_Homo sapiens_hsa040680.55158895
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54502827
130ABC transporters_Homo sapiens_hsa020100.54199255
131Purine metabolism_Homo sapiens_hsa002300.54148849
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53562432
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53248865
134Retinol metabolism_Homo sapiens_hsa008300.51945698
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51762102
136Homologous recombination_Homo sapiens_hsa034400.51580285
137Alzheimers disease_Homo sapiens_hsa050100.50096250
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49697934
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49431164
140Shigellosis_Homo sapiens_hsa051310.48228311
141Hippo signaling pathway_Homo sapiens_hsa043900.47308668
142Folate biosynthesis_Homo sapiens_hsa007900.47119497
143Insulin signaling pathway_Homo sapiens_hsa049100.47084130
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47028978
145Steroid biosynthesis_Homo sapiens_hsa001000.45957105
146Glucagon signaling pathway_Homo sapiens_hsa049220.45060864
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.45012423
148Salmonella infection_Homo sapiens_hsa051320.44999414
149Adherens junction_Homo sapiens_hsa045200.44887868
150Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43977339
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43463632
152Basal cell carcinoma_Homo sapiens_hsa052170.43017966
153Type I diabetes mellitus_Homo sapiens_hsa049400.42959600
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42284039
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41640927
156Non-homologous end-joining_Homo sapiens_hsa034500.37220022
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35675780
158Ovarian steroidogenesis_Homo sapiens_hsa049130.35525576
159Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33222116
160Metabolic pathways_Homo sapiens_hsa011000.32747369
161Sphingolipid metabolism_Homo sapiens_hsa006000.32518343

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