GPR22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.54325449
2ionotropic glutamate receptor signaling pathway (GO:0035235)5.36147305
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32831004
4glutamate receptor signaling pathway (GO:0007215)5.18752081
5synaptic vesicle exocytosis (GO:0016079)5.03002813
6protein localization to synapse (GO:0035418)5.02304728
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.01863882
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94729455
9neuron cell-cell adhesion (GO:0007158)4.89194274
10regulation of glutamate receptor signaling pathway (GO:1900449)4.83463346
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.77978297
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.71833451
13protein K11-linked deubiquitination (GO:0035871)4.56617521
14neuron-neuron synaptic transmission (GO:0007270)4.53824070
15neuronal action potential propagation (GO:0019227)4.53653885
16DNA double-strand break processing (GO:0000729)4.53108452
17synaptic transmission, glutamatergic (GO:0035249)4.52088949
18glutamate secretion (GO:0014047)4.39779898
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.27065382
20presynaptic membrane assembly (GO:0097105)4.23112871
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.18309433
22regulation of excitatory postsynaptic membrane potential (GO:0060079)4.16912956
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15069685
24regulation of synaptic vesicle exocytosis (GO:2000300)4.14574400
25neuron recognition (GO:0008038)4.07079022
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06885927
27response to pheromone (GO:0019236)4.06471040
28synaptic vesicle docking involved in exocytosis (GO:0016081)4.03260898
29atrial cardiac muscle cell action potential (GO:0086014)4.02966431
30locomotory exploration behavior (GO:0035641)4.02217861
31response to histamine (GO:0034776)4.00143685
32positive regulation of synapse maturation (GO:0090129)4.00024883
33neurotransmitter-gated ion channel clustering (GO:0072578)3.98926359
34presynaptic membrane organization (GO:0097090)3.96719454
35regulation of postsynaptic membrane potential (GO:0060078)3.96296391
36long-term synaptic potentiation (GO:0060291)3.94291281
37behavioral fear response (GO:0001662)3.94082211
38behavioral defense response (GO:0002209)3.94082211
39exploration behavior (GO:0035640)3.93326955
40regulation of synaptic vesicle transport (GO:1902803)3.85251411
41fear response (GO:0042596)3.80062621
42C4-dicarboxylate transport (GO:0015740)3.78629128
43regulation of neuronal synaptic plasticity (GO:0048168)3.72167064
44postsynaptic membrane organization (GO:0001941)3.70726571
45meiotic chromosome segregation (GO:0045132)3.66889909
46synaptic vesicle endocytosis (GO:0048488)3.66087810
47regulation of synaptic plasticity (GO:0048167)3.65838810
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64414575
49long-term memory (GO:0007616)3.61885398
50fucose catabolic process (GO:0019317)3.60481867
51L-fucose metabolic process (GO:0042354)3.60481867
52L-fucose catabolic process (GO:0042355)3.60481867
53axonal fasciculation (GO:0007413)3.58293014
54startle response (GO:0001964)3.56120813
55neurotransmitter secretion (GO:0007269)3.55068131
56regulation of dendritic spine morphogenesis (GO:0061001)3.55034505
57cochlea development (GO:0090102)3.49299678
58detection of calcium ion (GO:0005513)3.49233009
59inner ear receptor stereocilium organization (GO:0060122)3.45273509
60positive regulation of neurotransmitter secretion (GO:0001956)3.44474591
61regulation of glutamate secretion (GO:0014048)3.42252361
62positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41337174
63auditory receptor cell stereocilium organization (GO:0060088)3.40799185
64positive regulation of membrane potential (GO:0045838)3.38840135
65long term synaptic depression (GO:0060292)3.38438262
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.37375124
67negative regulation of dendrite development (GO:2000171)3.34847380
68synaptic vesicle maturation (GO:0016188)3.33170202
69behavioral response to cocaine (GO:0048148)3.32671420
70inositol phosphate catabolic process (GO:0071545)3.32170207
71transmission of nerve impulse (GO:0019226)3.30490712
72regulation of vesicle fusion (GO:0031338)3.30350668
73cerebellar granule cell differentiation (GO:0021707)3.28861781
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28496997
75cerebral cortex radially oriented cell migration (GO:0021799)3.27629244
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27214021
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27067195
78membrane depolarization (GO:0051899)3.25669756
79limb bud formation (GO:0060174)3.24005981
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.22251340
81ATP hydrolysis coupled proton transport (GO:0015991)3.21599361
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.21599361
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.19880508
84regulation of synapse maturation (GO:0090128)3.19269349
85regulation of dendritic spine development (GO:0060998)3.19120840
86respiratory chain complex IV assembly (GO:0008535)3.19068881
87learning (GO:0007612)3.18405946
88serotonin metabolic process (GO:0042428)3.18106864
89water-soluble vitamin biosynthetic process (GO:0042364)3.17456585
90dendritic spine morphogenesis (GO:0060997)3.16771810
91positive regulation of synapse assembly (GO:0051965)3.14211315
92ketone body metabolic process (GO:1902224)3.13575144
93innervation (GO:0060384)3.12423864
94replication fork processing (GO:0031297)3.11075428
95regulation of heat generation (GO:0031650)3.10159174
96dendritic spine organization (GO:0097061)3.08637056
97gamma-aminobutyric acid transport (GO:0015812)3.08234335
98cellular potassium ion homeostasis (GO:0030007)3.07768111
99neurotransmitter transport (GO:0006836)3.07388784
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07353612
101righting reflex (GO:0060013)3.05191302
102regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.05034235
103regulation of neurotransmitter secretion (GO:0046928)3.03786270
104positive regulation of neurotransmitter transport (GO:0051590)3.02520058
105proline transport (GO:0015824)3.02338127
106cerebellar Purkinje cell differentiation (GO:0021702)3.00402252
107synaptic transmission (GO:0007268)3.00156328
108transferrin transport (GO:0033572)2.99911756
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98696155
110neural tube formation (GO:0001841)2.97818089
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97557720
112regulation of synapse structural plasticity (GO:0051823)2.97304136
113RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96759952
114positive regulation of dendritic spine development (GO:0060999)2.96163042
115regulation of synaptic transmission (GO:0050804)2.95317309
116C-terminal protein lipidation (GO:0006501)2.93292836
117regulation of hexokinase activity (GO:1903299)2.92990393
118regulation of glucokinase activity (GO:0033131)2.92990393
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.92680251
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92052029
121regulation of voltage-gated calcium channel activity (GO:1901385)2.91592292
122membrane depolarization during action potential (GO:0086010)2.90644210
123polyol catabolic process (GO:0046174)2.90526058
124regulation of Rac GTPase activity (GO:0032314)2.88641468
125regulation of neuron projection regeneration (GO:0070570)2.88492562
126regulation of axon regeneration (GO:0048679)2.88492562
127regulation of cell communication by electrical coupling (GO:0010649)2.88185787
128synapsis (GO:0007129)2.86567467
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.85612538
130cellular ketone body metabolic process (GO:0046950)2.85044117
131positive regulation of protein autophosphorylation (GO:0031954)2.82602094
132C-terminal protein amino acid modification (GO:0018410)2.81118613
133regulation of cilium movement (GO:0003352)2.80716844
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.79767961
135detection of light stimulus involved in sensory perception (GO:0050962)2.78165547
136detection of light stimulus involved in visual perception (GO:0050908)2.78165547
137glycosphingolipid biosynthetic process (GO:0006688)2.76175570
138DNA-dependent DNA replication (GO:0006261)2.76149007
139cyclic nucleotide catabolic process (GO:0009214)2.75240996
140mitochondrial DNA replication (GO:0006264)2.70752250
141regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70216939
142establishment of nucleus localization (GO:0040023)2.66933895
143reflex (GO:0060004)2.61178027
144regulation of meiosis I (GO:0060631)2.59361375
145phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57396761
146inositol phosphate dephosphorylation (GO:0046855)2.57396761
147cAMP catabolic process (GO:0006198)2.56700220
148regulation of neurotransmitter uptake (GO:0051580)2.53598941
149regulation of DNA endoreduplication (GO:0032875)2.52389062
150axoneme assembly (GO:0035082)2.50059146
151double-strand break repair via homologous recombination (GO:0000724)2.50031405
152recombinational repair (GO:0000725)2.48519796
153cell wall macromolecule catabolic process (GO:0016998)2.48430092
154photoreceptor cell maintenance (GO:0045494)2.47630670
155somite development (GO:0061053)2.47166590
156retinal cone cell development (GO:0046549)2.46826747
157protein polyglutamylation (GO:0018095)2.46027100
158nucleotide transmembrane transport (GO:1901679)2.45794274
159behavioral response to nicotine (GO:0035095)2.44409259
160indole-containing compound catabolic process (GO:0042436)2.44118089
161indolalkylamine catabolic process (GO:0046218)2.44118089
162tryptophan catabolic process (GO:0006569)2.44118089
163acrosome assembly (GO:0001675)2.43619167
164positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.43000408
165positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42666523
166male meiosis (GO:0007140)2.41940950
167resolution of meiotic recombination intermediates (GO:0000712)2.41800822
168cytochrome complex assembly (GO:0017004)2.40398398
169keratinocyte development (GO:0003334)2.40337945
170tachykinin receptor signaling pathway (GO:0007217)2.37666071
171somatic hypermutation of immunoglobulin genes (GO:0016446)2.37377722
172somatic diversification of immune receptors via somatic mutation (GO:0002566)2.37377722
173indolalkylamine metabolic process (GO:0006586)2.37053749
174cornea development in camera-type eye (GO:0061303)2.35960122
175central nervous system neuron axonogenesis (GO:0021955)2.34821348
176protein prenylation (GO:0018342)2.34292530
177prenylation (GO:0097354)2.34292530
178negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34182335
179kynurenine metabolic process (GO:0070189)2.33534574
180regulation of protein kinase A signaling (GO:0010738)2.31903664
181negative regulation of JUN kinase activity (GO:0043508)2.31897237
182alanine transport (GO:0032328)2.30580019
183magnesium ion transport (GO:0015693)2.29116804
184reciprocal DNA recombination (GO:0035825)2.29034351
185reciprocal meiotic recombination (GO:0007131)2.29034351
186cilium morphogenesis (GO:0060271)2.28296976
187rRNA catabolic process (GO:0016075)2.28239635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.60976635
2GBX2_23144817_ChIP-Seq_PC3_Human4.58105733
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16934801
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.16506732
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12362812
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09579597
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75677675
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57400618
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57400618
10REST_21632747_ChIP-Seq_MESCs_Mouse2.57303577
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54687916
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.53838694
13TAF15_26573619_Chip-Seq_HEK293_Human2.52117856
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50766907
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47716876
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.40996838
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.38199591
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34797484
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.29221109
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27383020
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21406100
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.21385440
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19292764
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.03974633
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01861362
26SMAD4_21799915_ChIP-Seq_A2780_Human1.98197537
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.97409273
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.96850751
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96719129
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95095117
31P300_19829295_ChIP-Seq_ESCs_Human1.92468401
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87942966
33DROSHA_22980978_ChIP-Seq_HELA_Human1.87926624
34FUS_26573619_Chip-Seq_HEK293_Human1.85540242
35VDR_22108803_ChIP-Seq_LS180_Human1.85011970
36* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83719366
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82865129
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81849839
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.79614915
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78866973
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78397336
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71748828
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71357060
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71231913
45ZNF274_21170338_ChIP-Seq_K562_Hela1.69335913
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66966447
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66566010
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65497693
49CBP_20019798_ChIP-Seq_JUKART_Human1.65497693
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.64890054
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63515469
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62828643
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60252855
54AR_21572438_ChIP-Seq_LNCaP_Human1.59583705
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.56151282
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54095758
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.51917139
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.50113115
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49981108
60AR_25329375_ChIP-Seq_VCAP_Human1.49438439
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.49349285
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49029148
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47664491
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46584365
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44353613
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43468956
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38354941
68IGF1R_20145208_ChIP-Seq_DFB_Human1.38267865
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38030532
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36107514
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35985857
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.33679138
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.33345572
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32392128
75TCF4_22108803_ChIP-Seq_LS180_Human1.32167081
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31566343
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30988481
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.28491273
79STAT3_23295773_ChIP-Seq_U87_Human1.27312397
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26265968
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26033193
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.25329931
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24744191
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24641968
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24342271
86NANOG_19829295_ChIP-Seq_ESCs_Human1.23893342
87SOX2_19829295_ChIP-Seq_ESCs_Human1.23893342
88TCF4_23295773_ChIP-Seq_U87_Human1.23883558
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.21846043
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21667017
91RNF2_27304074_Chip-Seq_NSC_Mouse1.20757052
92TP53_16413492_ChIP-PET_HCT116_Human1.20356224
93JUN_21703547_ChIP-Seq_K562_Human1.18188201
94TP53_22573176_ChIP-Seq_HFKS_Human1.18157408
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17495405
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.17189000
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16562301
98P300_18555785_Chip-Seq_ESCs_Mouse1.16246966
99CDX2_22108803_ChIP-Seq_LS180_Human1.16227146
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.15840302
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.15812213
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15010978
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.14846296
104BCAT_22108803_ChIP-Seq_LS180_Human1.14619261
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14216136
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.13959825
107RUNX2_22187159_ChIP-Seq_PCA_Human1.13715251
108TP53_18474530_ChIP-ChIP_U2OS_Human1.13499654
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12630119
110* ER_23166858_ChIP-Seq_MCF-7_Human1.10846383
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09933039
112MYC_18940864_ChIP-ChIP_HL60_Human1.09728367
113AR_19668381_ChIP-Seq_PC3_Human1.08719562
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08519011
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07484915
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.07187149
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06896534
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.06862584
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.06285733
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05151151
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04914585
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04206790
123* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03781297
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03277215
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03277215
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.00786169
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.00784235
128NMYC_18555785_Chip-Seq_ESCs_Mouse1.00352849
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00323098
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99678929
131AHR_22903824_ChIP-Seq_MCF-7_Human0.99656157
132EST1_17652178_ChIP-ChIP_JURKAT_Human0.99613088
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99573835
134RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99071067
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.98365951
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96387043
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95771181
138KDM2B_26808549_Chip-Seq_REH_Human0.95663137
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95660679
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95052085
141* EWS_26573619_Chip-Seq_HEK293_Human0.94887820
142P53_22387025_ChIP-Seq_ESCs_Mouse0.93504061
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93470756
144SOX9_26525672_Chip-Seq_HEART_Mouse0.93380034
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92909045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.15842506
2MP0004859_abnormal_synaptic_plasticity6.02640577
3MP0003635_abnormal_synaptic_transmissio4.12506656
4MP0009745_abnormal_behavioral_response3.59487348
5MP0002063_abnormal_learning/memory/cond3.43517568
6MP0004270_analgesia3.35286349
7MP0001968_abnormal_touch/_nociception3.21558225
8MP0003195_calcinosis3.20974338
9MP0002064_seizures3.15021293
10MP0002736_abnormal_nociception_after3.03250323
11MP0002572_abnormal_emotion/affect_behav2.97678449
12MP0009046_muscle_twitch2.93404945
13MP0001501_abnormal_sleep_pattern2.72423220
14MP0002272_abnormal_nervous_system2.67650575
15MP0001440_abnormal_grooming_behavior2.65077518
16MP0002102_abnormal_ear_morphology2.62846472
17MP0000372_irregular_coat_pigmentation2.60833979
18MP0002837_dystrophic_cardiac_calcinosis2.49643408
19MP0002735_abnormal_chemical_nociception2.44107001
20MP0000569_abnormal_digit_pigmentation2.26483237
21MP0001486_abnormal_startle_reflex2.26099202
22MP0002734_abnormal_mechanical_nocicepti2.22778221
23MP0002067_abnormal_sensory_capabilities2.09013452
24MP0006276_abnormal_autonomic_nervous1.96928114
25MP0004043_abnormal_pH_regulation1.94204770
26MP0003329_amyloid_beta_deposits1.90523057
27MP0002184_abnormal_innervation1.84690732
28MP0001529_abnormal_vocalization1.82656043
29MP0002822_catalepsy1.79950292
30MP0000778_abnormal_nervous_system1.78600768
31MP0001970_abnormal_pain_threshold1.77727931
32MP0002733_abnormal_thermal_nociception1.76703428
33MP0000427_abnormal_hair_cycle1.75559930
34MP0005423_abnormal_somatic_nervous1.75516750
35MP0003787_abnormal_imprinting1.74907768
36MP0006072_abnormal_retinal_apoptosis1.71836817
37MP0004924_abnormal_behavior1.70020736
38MP0005386_behavior/neurological_phenoty1.70020736
39MP0005367_renal/urinary_system_phenotyp1.69178090
40MP0000516_abnormal_urinary_system1.69178090
41MP0005253_abnormal_eye_physiology1.69159019
42MP0001188_hyperpigmentation1.67435572
43MP0009780_abnormal_chondrocyte_physiolo1.67159403
44MP0008057_abnormal_DNA_replication1.60444892
45MP0003879_abnormal_hair_cell1.60118375
46MP0002557_abnormal_social/conspecific_i1.58534315
47MP0002938_white_spotting1.56975267
48MP0008569_lethality_at_weaning1.52742671
49MP0004145_abnormal_muscle_electrophysio1.50717575
50MP0001905_abnormal_dopamine_level1.49100903
51MP0002090_abnormal_vision1.47172576
52MP0008058_abnormal_DNA_repair1.44820234
53MP0004215_abnormal_myocardial_fiber1.42040296
54MP0004811_abnormal_neuron_physiology1.39812861
55MP0000751_myopathy1.39790826
56MP0005646_abnormal_pituitary_gland1.37955789
57MP0008775_abnormal_heart_ventricle1.37415203
58MP0003121_genomic_imprinting1.35972957
59MP0001984_abnormal_olfaction1.34480194
60MP0002066_abnormal_motor_capabilities/c1.33330005
61MP0001986_abnormal_taste_sensitivity1.31003900
62MP0002909_abnormal_adrenal_gland1.28926234
63MP0002751_abnormal_autonomic_nervous1.28870081
64MP0004147_increased_porphyrin_level1.26955853
65MP0000955_abnormal_spinal_cord1.26725996
66MP0004142_abnormal_muscle_tone1.25707961
67MP0002882_abnormal_neuron_morphology1.24594268
68MP0002876_abnormal_thyroid_physiology1.23983313
69MP0003122_maternal_imprinting1.21571006
70MP0008875_abnormal_xenobiotic_pharmacok1.17727775
71MP0005075_abnormal_melanosome_morpholog1.17056483
72MP0003718_maternal_effect1.16400957
73MP0004858_abnormal_nervous_system1.15936404
74MP0001324_abnormal_eye_pigmentation1.14671245
75MP0005408_hypopigmentation1.13399974
76MP0000647_abnormal_sebaceous_gland1.12188551
77MP0010386_abnormal_urinary_bladder1.11134684
78MP0003633_abnormal_nervous_system1.09686470
79MP0004085_abnormal_heartbeat1.09411138
80MP0001502_abnormal_circadian_rhythm1.08173436
81MP0003646_muscle_fatigue1.05288715
82MP0004510_myositis1.03174025
83* MP0004484_altered_response_of1.02084747
84MP0003631_nervous_system_phenotype1.00319567
85MP0002152_abnormal_brain_morphology0.98472655
86MP0005174_abnormal_tail_pigmentation0.94457308
87MP0000015_abnormal_ear_pigmentation0.92242858
88MP0005645_abnormal_hypothalamus_physiol0.91844283
89MP0001177_atelectasis0.91731806
90MP0001963_abnormal_hearing_physiology0.90369821
91MP0005171_absent_coat_pigmentation0.89410612
92MP0005551_abnormal_eye_electrophysiolog0.88265129
93MP0005310_abnormal_salivary_gland0.88153353
94MP0003136_yellow_coat_color0.86987664
95MP0000604_amyloidosis0.86352275
96MP0008874_decreased_physiological_sensi0.85808042
97MP0005409_darkened_coat_color0.85775552
98MP0005535_abnormal_body_temperature0.85190215
99MP0002229_neurodegeneration0.84819883
100MP0008872_abnormal_physiological_respon0.84659105
101MP0004885_abnormal_endolymph0.83534101
102MP0002095_abnormal_skin_pigmentation0.83155815
103MP0005395_other_phenotype0.82235655
104MP0002069_abnormal_eating/drinking_beha0.81908176
105MP0004036_abnormal_muscle_relaxation0.81687327
106MP0004742_abnormal_vestibular_system0.80675922
107MP0003137_abnormal_impulse_conducting0.80615399
108MP0000538_abnormal_urinary_bladder0.80410059
109MP0002168_other_aberrant_phenotype0.79433199
110MP0005410_abnormal_fertilization0.78883553
111MP0010094_abnormal_chromosome_stability0.78451945
112MP0000013_abnormal_adipose_tissue0.78032801
113MP0002233_abnormal_nose_morphology0.77711604
114MP0005167_abnormal_blood-brain_barrier0.76941480
115MP0001664_abnormal_digestion0.76093390
116MP0005195_abnormal_posterior_eye0.75957617
117MP0005620_abnormal_muscle_contractility0.72962104
118MP0000613_abnormal_salivary_gland0.72739328
119MP0006292_abnormal_olfactory_placode0.72604403
120MP0002693_abnormal_pancreas_physiology0.71910939
121MP0003698_abnormal_male_reproductive0.71594519
122MP0003632_abnormal_nervous_system0.71560504
123MP0001485_abnormal_pinna_reflex0.68913513
124MP0002752_abnormal_somatic_nervous0.68834979
125MP0005187_abnormal_penis_morphology0.66026153
126MP0000026_abnormal_inner_ear0.65110203
127MP0008877_abnormal_DNA_methylation0.64480388
128MP0001765_abnormal_ion_homeostasis0.63482734
129MP0009379_abnormal_foot_pigmentation0.62723435
130MP0004233_abnormal_muscle_weight0.58663364
131MP0002638_abnormal_pupillary_reflex0.58256963
132MP0000631_abnormal_neuroendocrine_gland0.58177251
133MP0005499_abnormal_olfactory_system0.57991340
134MP0005394_taste/olfaction_phenotype0.57991340
135MP0002972_abnormal_cardiac_muscle0.57295371
136MP0002234_abnormal_pharynx_morphology0.56409209
137MP0006035_abnormal_mitochondrial_morpho0.56173105
138MP0005595_abnormal_vascular_smooth0.53521642
139MP0000749_muscle_degeneration0.51787161
140MP0006138_congestive_heart_failure0.50002942
141MP0001943_abnormal_respiration0.49687859
142MP0004084_abnormal_cardiac_muscle0.49326796

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.74826858
2Focal seizures (HP:0007359)5.69049335
3Atonic seizures (HP:0010819)5.57858034
4Epileptic encephalopathy (HP:0200134)5.55086803
5Hyperventilation (HP:0002883)5.42099433
6Visual hallucinations (HP:0002367)5.06755395
7Febrile seizures (HP:0002373)5.00790773
8Myokymia (HP:0002411)4.81552331
9Absence seizures (HP:0002121)4.65081964
10Dialeptic seizures (HP:0011146)4.42059268
11Congenital stationary night blindness (HP:0007642)4.03237386
12Progressive cerebellar ataxia (HP:0002073)3.94932088
13Abnormality of the labia minora (HP:0012880)3.91387818
14Broad-based gait (HP:0002136)3.90925734
15Amblyopia (HP:0000646)3.82352524
16Generalized tonic-clonic seizures (HP:0002069)3.77151710
17Neoplasm of the adrenal cortex (HP:0100641)3.48853961
18Abnormal rod and cone electroretinograms (HP:0008323)3.45038165
19Gaze-evoked nystagmus (HP:0000640)3.29617711
20Cerebral inclusion bodies (HP:0100314)3.23681884
21Acute necrotizing encephalopathy (HP:0006965)3.20734387
22Pancreatic cysts (HP:0001737)3.16215135
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.15646140
24Hypoplasia of the fovea (HP:0007750)3.15646140
25Truncal ataxia (HP:0002078)3.10256983
26Drooling (HP:0002307)3.09087865
27Excessive salivation (HP:0003781)3.09087865
28Poor eye contact (HP:0000817)3.07691774
29Abnormal mitochondria in muscle tissue (HP:0008316)3.04109873
30Abnormality of binocular vision (HP:0011514)3.03233508
31Diplopia (HP:0000651)3.03233508
32Dysdiadochokinesis (HP:0002075)2.89230379
33Dysmetria (HP:0001310)2.89045584
34Epileptiform EEG discharges (HP:0011182)2.88589832
35Progressive macrocephaly (HP:0004481)2.88264326
36Anxiety (HP:0000739)2.85384908
37Pancreatic fibrosis (HP:0100732)2.81410576
38True hermaphroditism (HP:0010459)2.79911142
39Action tremor (HP:0002345)2.79421492
40Ependymoma (HP:0002888)2.77926482
41Impaired vibration sensation in the lower limbs (HP:0002166)2.75828698
42Impaired social interactions (HP:0000735)2.73241354
43Abnormal social behavior (HP:0012433)2.73241354
44Absent speech (HP:0001344)2.72615090
45Neoplasm of the oral cavity (HP:0100649)2.70239532
46Abnormality of the fovea (HP:0000493)2.68750898
47Supranuclear gaze palsy (HP:0000605)2.67857804
48Impaired smooth pursuit (HP:0007772)2.67046364
49Abnormality of macular pigmentation (HP:0008002)2.67014789
50Inability to walk (HP:0002540)2.66988473
51Glioma (HP:0009733)2.66726708
52Abnormality of midbrain morphology (HP:0002418)2.65196481
53Molar tooth sign on MRI (HP:0002419)2.65196481
54Hemiparesis (HP:0001269)2.63422381
55Delusions (HP:0000746)2.61816641
56Progressive inability to walk (HP:0002505)2.60057395
57Mitochondrial inheritance (HP:0001427)2.58443741
58Scanning speech (HP:0002168)2.58354380
59Abnormality of the astrocytes (HP:0100707)2.56047995
60Astrocytoma (HP:0009592)2.56047995
61Protruding tongue (HP:0010808)2.50283172
62Hypothermia (HP:0002045)2.49169707
63Depression (HP:0000716)2.47982656
64Termporal pattern (HP:0011008)2.45284464
65Insidious onset (HP:0003587)2.45284464
66Neoplasm of the adrenal gland (HP:0100631)2.45102729
67Decreased central vision (HP:0007663)2.43733033
68EEG with generalized epileptiform discharges (HP:0011198)2.43230865
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43122208
70Acute encephalopathy (HP:0006846)2.41320594
71Intestinal atresia (HP:0011100)2.40903982
72Albinism (HP:0001022)2.40236659
73Attenuation of retinal blood vessels (HP:0007843)2.37916982
74Neurofibrillary tangles (HP:0002185)2.37391398
75Dysmetric saccades (HP:0000641)2.37218258
76Aplasia/Hypoplasia of the macula (HP:0008059)2.35171877
77Abnormal eating behavior (HP:0100738)2.30900346
78Pheochromocytoma (HP:0002666)2.30217004
79Abnormality of the lower motor neuron (HP:0002366)2.28532239
80Abnormality of the renal cortex (HP:0011035)2.27849762
81Nephronophthisis (HP:0000090)2.26145568
82Syncope (HP:0001279)2.24583875
83Sudden death (HP:0001699)2.24119442
84Abnormality of ocular smooth pursuit (HP:0000617)2.22243395
85Urinary bladder sphincter dysfunction (HP:0002839)2.19518406
86Type II lissencephaly (HP:0007260)2.19447851
87Increased CSF lactate (HP:0002490)2.19189963
88Hypsarrhythmia (HP:0002521)2.18388472
89Status epilepticus (HP:0002133)2.17836000
90Aplasia/Hypoplasia affecting the retina (HP:0008061)2.16058412
91Thyroiditis (HP:0100646)2.15989659
92Renal cortical cysts (HP:0000803)2.12460601
93Gait imbalance (HP:0002141)2.12341818
94Neuroendocrine neoplasm (HP:0100634)2.10014755
95Widely spaced teeth (HP:0000687)2.08036549
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07934011
97Genetic anticipation (HP:0003743)2.07874378
98Abnormality of salivation (HP:0100755)2.07656927
99Abnormality of glycolysis (HP:0004366)2.05955814
100Increased serum pyruvate (HP:0003542)2.05955814
101Abnormality of the corticospinal tract (HP:0002492)2.04337047
102Colon cancer (HP:0003003)2.04193236
103Bradykinesia (HP:0002067)2.03953432
104Hamartoma of the eye (HP:0010568)2.02054660
105Generalized myoclonic seizures (HP:0002123)2.01941860
106Blue irides (HP:0000635)2.01895812
107Psychosis (HP:0000709)1.99493683
108Severe visual impairment (HP:0001141)1.99405567
109Cystic liver disease (HP:0006706)1.99332859
110Optic disc pallor (HP:0000543)1.98404636
111Hydroureter (HP:0000072)1.98361513
112Furrowed tongue (HP:0000221)1.98186261
113Lissencephaly (HP:0001339)1.98015229
114Aqueductal stenosis (HP:0002410)1.97986130
115Hepatocellular necrosis (HP:0001404)1.97505907
116Fair hair (HP:0002286)1.96636320
117Medial flaring of the eyebrow (HP:0010747)1.95280821
118Chronic hepatic failure (HP:0100626)1.94701709
119Impaired vibratory sensation (HP:0002495)1.94108204
120Urinary urgency (HP:0000012)1.93413829
121Thickened helices (HP:0000391)1.93179272
122Stereotypic behavior (HP:0000733)1.91791767
123Decreased circulating renin level (HP:0003351)1.91137871
124Postural instability (HP:0002172)1.90669739
125Abnormal hair whorl (HP:0010721)1.90210493
126Fetal akinesia sequence (HP:0001989)1.89578872
127Congenital primary aphakia (HP:0007707)1.89306151
128Polyphagia (HP:0002591)1.88073438
129Pachygyria (HP:0001302)1.87701667
130Volvulus (HP:0002580)1.87358329
131Pigmentary retinal degeneration (HP:0001146)1.87022937
132Incomplete penetrance (HP:0003829)1.86865545
133Muscle hypertrophy of the lower extremities (HP:0008968)1.86635248
134Gait ataxia (HP:0002066)1.85602274
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.85286273
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85286273
137Unsteady gait (HP:0002317)1.83623845
138Generalized hypopigmentation (HP:0007513)1.83031465
139Testicular atrophy (HP:0000029)1.82722453
140Heterochromia iridis (HP:0001100)1.80840921
141Generalized hypopigmentation of hair (HP:0011358)1.79527349
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.79515963
143X-linked dominant inheritance (HP:0001423)1.78188496
144Global brain atrophy (HP:0002283)1.77756083
145Abnormality of the renal medulla (HP:0100957)1.77255355
146Polydipsia (HP:0001959)1.75874988
147Abnormal drinking behavior (HP:0030082)1.75874988
148Nephrogenic diabetes insipidus (HP:0009806)1.74201259
149Hyperthyroidism (HP:0000836)1.74081013
150Abnormality of chromosome stability (HP:0003220)1.73346108
151Muscular hypotonia of the trunk (HP:0008936)1.72337548
152Bony spicule pigmentary retinopathy (HP:0007737)1.71050772
153Biliary tract neoplasm (HP:0100574)1.69912942
154Ketoacidosis (HP:0001993)1.69162938
155Large for gestational age (HP:0001520)1.69124217
156Exotropia (HP:0000577)1.69084480
157Severe Myopia (HP:0011003)1.68414417
158Small hand (HP:0200055)1.67951054
159Astigmatism (HP:0000483)1.67556179
160Bifid tongue (HP:0010297)1.66988874
161Abolished electroretinogram (ERG) (HP:0000550)1.66654386
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.66256772
163Limb dystonia (HP:0002451)1.64660698
164Reduced antithrombin III activity (HP:0001976)1.63565205
165Ectopic kidney (HP:0000086)1.62974468
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62631538
167Sloping forehead (HP:0000340)1.61687263
168Stomach cancer (HP:0012126)1.61512453
169Meningioma (HP:0002858)1.61006043
170Central scotoma (HP:0000603)1.60656098
171Narrow forehead (HP:0000341)1.60088400
172Type I transferrin isoform profile (HP:0003642)1.59653536
173Long nose (HP:0003189)1.59039419
174Congenital sensorineural hearing impairment (HP:0008527)1.56548145
175Genital tract atresia (HP:0001827)1.56190581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.19840854
2EPHA45.22551839
3NTRK34.81319524
4CASK3.89583795
5RIPK43.54120614
6MAP3K43.27062314
7MAP3K123.13506807
8MAP2K73.05374933
9PLK22.66966107
10MAP4K22.52635899
11MAP3K92.49669859
12TRIM282.46611511
13MINK12.22286544
14DAPK12.18091819
15NUAK12.12163121
16MAP2K42.11929440
17ERBB32.11313262
18PNCK2.06039661
19FGFR22.04179009
20DAPK22.03437159
21GRK51.82087169
22ACVR1B1.79434980
23MARK11.79098589
24CDK191.78848486
25BMPR1B1.77932578
26BMPR21.75244078
27PTK2B1.70953862
28EIF2AK31.67309839
29GRK11.64959091
30NME11.63419519
31KSR11.62236960
32MKNK21.53811893
33ZAK1.43394118
34GRK71.41141747
35ARAF1.38562280
36BRSK21.35326553
37CAMK2A1.35177777
38NTRK21.35011817
39CAMK2B1.33341066
40KSR21.31587152
41PRKCG1.31207783
42FGR1.29348084
43PLK31.28070577
44MST41.27661188
45BLK1.26424112
46PRPF4B1.25890808
47TNIK1.23724488
48ADRBK21.23506848
49FES1.21982246
50CDK51.20605554
51PAK61.13456737
52WEE11.12613554
53STK391.12491453
54SIK21.11938309
55AKT31.10134218
56MAPK131.07693162
57EIF2AK11.04035789
58OXSR11.03907118
59NTRK10.98951399
60CCNB10.97372121
61GRK60.95488569
62MAP3K130.95059798
63SIK30.94450444
64TAOK30.93442932
65PLK40.92399196
66CSNK1G10.91184931
67RAF10.88706690
68PDK40.82255969
69PDK30.82255969
70TGFBR20.81761717
71CSNK1G30.81564164
72NEK10.81371817
73INSRR0.80355135
74STK38L0.79830166
75CAMKK20.79048571
76PRKCE0.78921509
77CAMK2D0.77336301
78CDK30.76538027
79MYLK0.75789930
80STK30.75479670
81STK380.75253580
82CSNK1A1L0.72772682
83CAMKK10.71685282
84DYRK1A0.71538066
85SGK10.70250383
86CAMK10.67499644
87CDK180.67003097
88FER0.66207751
89MKNK10.65125801
90SGK4940.64175824
91SGK2230.64175824
92BCR0.63189810
93SGK20.62943887
94CDK150.60186462
95CDK140.60048646
96ROCK10.58219859
97MUSK0.57859009
98DYRK20.57184468
99MAP3K20.56395131
100MAP3K60.56222371
101PKN10.55919579
102CAMK1D0.55495190
103CAMK2G0.55010457
104BRAF0.54727796
105ROCK20.53431983
106CAMK40.51664977
107ATM0.50466732
108MAPK120.50160418
109CDK11A0.50041834
110CAMK1G0.49318209
111UHMK10.49298332
112ADRBK10.47199637
113BUB10.47073282
114OBSCN0.46646581
115PLK10.46087313
116PAK30.45337839
117TSSK60.45070157
118STK110.44648758
119CDC42BPA0.44623236
120MAPKAPK50.44420895
121DAPK30.44252014
122CSNK1A10.44069014
123PHKG20.43312811
124PHKG10.43312811
125TXK0.42833585
126CSNK1G20.41285342
127PRKACA0.41026815
128PDK20.39942946
129NLK0.38003204
130WNK30.37984379
131CSNK1D0.37602677
132LATS20.37055476
133MAP2K10.36994468
134ATR0.36512782
135PINK10.36388232
136FYN0.36306823
137MARK20.35976729
138PDK10.35539339
139PDPK10.35283812
140ABL10.34577831
141WNK40.33707976
142PRKD30.32789294
143PRKDC0.32507682
144PRKCA0.32389140
145RPS6KA30.32290382
146VRK10.31460817
147MAP3K70.31311654
148BRSK10.31285781
149PRKCZ0.30891230
150PRKCQ0.30830013
151DMPK0.29931895
152TRPM70.29905399
153TYRO30.29522000
154TNK20.28303189
155PRKG10.28107534

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.65412811
2Long-term potentiation_Homo sapiens_hsa047203.13584761
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03041580
4Synaptic vesicle cycle_Homo sapiens_hsa047213.00144630
5Propanoate metabolism_Homo sapiens_hsa006402.91863582
6Circadian entrainment_Homo sapiens_hsa047132.79674370
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71181727
8Amphetamine addiction_Homo sapiens_hsa050312.70650670
9Glutamatergic synapse_Homo sapiens_hsa047242.65396230
10Regulation of autophagy_Homo sapiens_hsa041402.54727012
11Collecting duct acid secretion_Homo sapiens_hsa049662.54098536
12Morphine addiction_Homo sapiens_hsa050322.47905614
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45146110
14GABAergic synapse_Homo sapiens_hsa047272.44670297
15Non-homologous end-joining_Homo sapiens_hsa034502.37022567
16Salivary secretion_Homo sapiens_hsa049702.34244834
17Olfactory transduction_Homo sapiens_hsa047402.29957348
18Butanoate metabolism_Homo sapiens_hsa006502.23449876
19Oxidative phosphorylation_Homo sapiens_hsa001902.20417148
20Protein export_Homo sapiens_hsa030602.20057052
21Taste transduction_Homo sapiens_hsa047422.19657221
22Dopaminergic synapse_Homo sapiens_hsa047282.15676274
23Renin secretion_Homo sapiens_hsa049242.00948570
24Caffeine metabolism_Homo sapiens_hsa002321.89183737
25Calcium signaling pathway_Homo sapiens_hsa040201.89132960
26Long-term depression_Homo sapiens_hsa047301.88026369
27Serotonergic synapse_Homo sapiens_hsa047261.85982111
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84631533
29Alzheimers disease_Homo sapiens_hsa050101.83133791
30Gastric acid secretion_Homo sapiens_hsa049711.75953408
31Vitamin B6 metabolism_Homo sapiens_hsa007501.71865671
32Insulin secretion_Homo sapiens_hsa049111.70232703
33Oxytocin signaling pathway_Homo sapiens_hsa049211.67879619
34Cardiac muscle contraction_Homo sapiens_hsa042601.65290043
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64709021
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63980780
37Selenocompound metabolism_Homo sapiens_hsa004501.62025693
38Fanconi anemia pathway_Homo sapiens_hsa034601.59726125
39Cholinergic synapse_Homo sapiens_hsa047251.58053876
40Ether lipid metabolism_Homo sapiens_hsa005651.57321308
41Homologous recombination_Homo sapiens_hsa034401.57200562
42Linoleic acid metabolism_Homo sapiens_hsa005911.55602346
43Parkinsons disease_Homo sapiens_hsa050121.51818368
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47561212
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.47537994
46Vibrio cholerae infection_Homo sapiens_hsa051101.46603558
47Tryptophan metabolism_Homo sapiens_hsa003801.37722321
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34267938
49RNA degradation_Homo sapiens_hsa030181.30377359
50GnRH signaling pathway_Homo sapiens_hsa049121.28850994
51Basal transcription factors_Homo sapiens_hsa030221.25747090
52Nitrogen metabolism_Homo sapiens_hsa009101.25740066
53Cocaine addiction_Homo sapiens_hsa050301.23688720
54cAMP signaling pathway_Homo sapiens_hsa040241.23242119
55Huntingtons disease_Homo sapiens_hsa050161.19831268
56Gap junction_Homo sapiens_hsa045401.19133729
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18018504
58Sulfur metabolism_Homo sapiens_hsa009201.16847698
59Phototransduction_Homo sapiens_hsa047441.14984958
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14872313
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14034011
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13275005
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10793161
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10624830
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10599906
66Fatty acid elongation_Homo sapiens_hsa000621.10290570
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09795949
68Primary bile acid biosynthesis_Homo sapiens_hsa001201.07416528
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07056528
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.05226015
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05095745
72Axon guidance_Homo sapiens_hsa043601.00363837
73Estrogen signaling pathway_Homo sapiens_hsa049150.98495897
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.94855992
75One carbon pool by folate_Homo sapiens_hsa006700.93566995
76Melanogenesis_Homo sapiens_hsa049160.92004117
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90957085
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89395687
79Proteasome_Homo sapiens_hsa030500.87313520
80beta-Alanine metabolism_Homo sapiens_hsa004100.86443049
81RNA polymerase_Homo sapiens_hsa030200.86398304
82Fatty acid metabolism_Homo sapiens_hsa012120.85637357
83Pancreatic secretion_Homo sapiens_hsa049720.85516120
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84139629
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83308422
86Glioma_Homo sapiens_hsa052140.83202083
87Type II diabetes mellitus_Homo sapiens_hsa049300.78672061
88Peroxisome_Homo sapiens_hsa041460.78310755
89Dilated cardiomyopathy_Homo sapiens_hsa054140.78092357
90Steroid biosynthesis_Homo sapiens_hsa001000.76416621
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75483101
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74661800
93Oocyte meiosis_Homo sapiens_hsa041140.72987260
94Mismatch repair_Homo sapiens_hsa034300.71873457
95Fatty acid degradation_Homo sapiens_hsa000710.70631874
96Glucagon signaling pathway_Homo sapiens_hsa049220.68626018
97Sphingolipid metabolism_Homo sapiens_hsa006000.67742326
98ErbB signaling pathway_Homo sapiens_hsa040120.67509128
99African trypanosomiasis_Homo sapiens_hsa051430.65416248
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65368652
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64634096
102Rheumatoid arthritis_Homo sapiens_hsa053230.62980049
103Purine metabolism_Homo sapiens_hsa002300.60056284
104Thyroid hormone synthesis_Homo sapiens_hsa049180.59628928
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59200340
106Choline metabolism in cancer_Homo sapiens_hsa052310.56901058
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.56602667
108Lysine degradation_Homo sapiens_hsa003100.56474522
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54101992
110MAPK signaling pathway_Homo sapiens_hsa040100.53097156
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52959754
112Retinol metabolism_Homo sapiens_hsa008300.52092147
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51417022
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50824637
115Metabolic pathways_Homo sapiens_hsa011000.50129591
116VEGF signaling pathway_Homo sapiens_hsa043700.49963461
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.47611465
118Ras signaling pathway_Homo sapiens_hsa040140.45822408
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45475767
120Inositol phosphate metabolism_Homo sapiens_hsa005620.45261877
121ABC transporters_Homo sapiens_hsa020100.44432444
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41065177
123Dorso-ventral axis formation_Homo sapiens_hsa043200.40726377
124Chemical carcinogenesis_Homo sapiens_hsa052040.40354310
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39612048
126Rap1 signaling pathway_Homo sapiens_hsa040150.39115639
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39033519
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38929852
129Arginine and proline metabolism_Homo sapiens_hsa003300.38078529
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36516242
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33195627
132Fat digestion and absorption_Homo sapiens_hsa049750.32978635
133Histidine metabolism_Homo sapiens_hsa003400.31182179
134Pyruvate metabolism_Homo sapiens_hsa006200.30598234
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30349894
136Phagosome_Homo sapiens_hsa041450.29411561
137Wnt signaling pathway_Homo sapiens_hsa043100.29078941
138Alcoholism_Homo sapiens_hsa050340.27727355
139Circadian rhythm_Homo sapiens_hsa047100.26918421
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25686810
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24336211
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24071369
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.23706192
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23150909
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.23016973
146Type I diabetes mellitus_Homo sapiens_hsa049400.22881412
147Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21700558
148Prion diseases_Homo sapiens_hsa050200.21542262
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18593134
150Mineral absorption_Homo sapiens_hsa049780.16342002
151Bile secretion_Homo sapiens_hsa049760.15253750
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14540463
153Insulin signaling pathway_Homo sapiens_hsa049100.13893581
154Ovarian steroidogenesis_Homo sapiens_hsa049130.12988479
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11629039

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