GPR26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.54637225
2synaptic vesicle maturation (GO:0016188)6.26425114
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.15785083
4locomotory exploration behavior (GO:0035641)6.06830641
5vocalization behavior (GO:0071625)5.82632709
6glutamate secretion (GO:0014047)5.68416569
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.63743832
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.56717404
9synaptic vesicle exocytosis (GO:0016079)5.54849251
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.40965841
11regulation of glutamate receptor signaling pathway (GO:1900449)5.24456555
12regulation of synaptic vesicle exocytosis (GO:2000300)5.18662270
13protein localization to synapse (GO:0035418)5.08673023
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.86959160
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.85789762
16dopamine transport (GO:0015872)4.83369064
17regulation of neuronal synaptic plasticity (GO:0048168)4.76976061
18neuron cell-cell adhesion (GO:0007158)4.74789956
19exploration behavior (GO:0035640)4.69577683
20neuronal action potential propagation (GO:0019227)4.63197162
21regulation of synaptic vesicle transport (GO:1902803)4.61842322
22dendritic spine morphogenesis (GO:0060997)4.54450234
23synaptic transmission, glutamatergic (GO:0035249)4.51043604
24neurotransmitter-gated ion channel clustering (GO:0072578)4.42357508
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42245367
26neurotransmitter secretion (GO:0007269)4.41707302
27regulation of synapse structural plasticity (GO:0051823)4.40914687
28layer formation in cerebral cortex (GO:0021819)4.35183650
29glutamate receptor signaling pathway (GO:0007215)4.29821159
30neuron-neuron synaptic transmission (GO:0007270)4.21881236
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.16804924
32long-term memory (GO:0007616)4.12795908
33positive regulation of membrane potential (GO:0045838)4.12427821
34serotonin metabolic process (GO:0042428)4.11819625
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07598906
36proline transport (GO:0015824)4.03824309
37gamma-aminobutyric acid transport (GO:0015812)4.00726091
38regulation of dendritic spine morphogenesis (GO:0061001)3.92853871
39regulation of postsynaptic membrane potential (GO:0060078)3.87754793
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86074564
41catecholamine transport (GO:0051937)3.82743485
42dopamine biosynthetic process (GO:0042416)3.82230042
43regulation of synaptic plasticity (GO:0048167)3.80926956
44behavioral response to nicotine (GO:0035095)3.78818852
45positive regulation of neurotransmitter secretion (GO:0001956)3.73757922
46startle response (GO:0001964)3.68912502
47neuron recognition (GO:0008038)3.66665682
48postsynaptic membrane organization (GO:0001941)3.64466174
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62388335
50cellular potassium ion homeostasis (GO:0030007)3.61266470
51primary amino compound metabolic process (GO:1901160)3.60946860
52neurotransmitter transport (GO:0006836)3.59728096
53auditory behavior (GO:0031223)3.59713877
54regulation of neurotransmitter secretion (GO:0046928)3.59702485
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58033427
56long-term synaptic potentiation (GO:0060291)3.56854333
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.54940469
58neuromuscular synaptic transmission (GO:0007274)3.53295550
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.52807347
60positive regulation of neurotransmitter transport (GO:0051590)3.51626361
61transmission of nerve impulse (GO:0019226)3.49955342
62activation of protein kinase A activity (GO:0034199)3.49041190
63alanine transport (GO:0032328)3.48340829
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.46834187
65presynaptic membrane assembly (GO:0097105)3.46013803
66neuromuscular process controlling balance (GO:0050885)3.45947492
67positive regulation of synapse maturation (GO:0090129)3.44920250
68regulation of dendritic spine development (GO:0060998)3.42887546
69response to auditory stimulus (GO:0010996)3.42317940
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.41399847
71synaptic vesicle endocytosis (GO:0048488)3.40709566
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39206569
73axonal fasciculation (GO:0007413)3.39048516
74response to amphetamine (GO:0001975)3.38386419
75L-amino acid import (GO:0043092)3.35841887
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33157557
77regulation of neurotransmitter levels (GO:0001505)3.31904376
78regulation of neurotransmitter transport (GO:0051588)3.31322940
79dendritic spine organization (GO:0097061)3.31035291
80phosphorelay signal transduction system (GO:0000160)3.30095663
81regulation of vesicle fusion (GO:0031338)3.29040681
82dendrite morphogenesis (GO:0048813)3.27661872
83membrane depolarization (GO:0051899)3.25755581
84prepulse inhibition (GO:0060134)3.21147626
85positive regulation of dendritic spine development (GO:0060999)3.20130655
86learning (GO:0007612)3.18954179
87glycine transport (GO:0015816)3.18208775
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17727036
89sodium ion export (GO:0071436)3.16992583
90presynaptic membrane organization (GO:0097090)3.16406544
91response to histamine (GO:0034776)3.16245858
92membrane hyperpolarization (GO:0060081)3.16108846
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15760916
94neuronal action potential (GO:0019228)3.14693797
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13577361
96positive regulation of synaptic transmission (GO:0050806)3.13185927
97cerebellar Purkinje cell differentiation (GO:0021702)3.12785943
98righting reflex (GO:0060013)3.12178746
99regulation of dopamine secretion (GO:0014059)3.11415704
100synapse assembly (GO:0007416)3.08780253
101neuronal ion channel clustering (GO:0045161)3.07930293
102membrane depolarization during action potential (GO:0086010)3.07207054
103regulation of synaptic transmission (GO:0050804)3.07044034
104behavioral fear response (GO:0001662)3.06829900
105behavioral defense response (GO:0002209)3.06829900
106regulation of calcium ion-dependent exocytosis (GO:0017158)3.03264097
107cAMP catabolic process (GO:0006198)3.01868439
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01754300
109social behavior (GO:0035176)3.01512886
110intraspecies interaction between organisms (GO:0051703)3.01512886
111innervation (GO:0060384)3.01316976
112synaptic transmission (GO:0007268)3.01232978
113regulation of voltage-gated calcium channel activity (GO:1901385)3.00609159
114behavioral response to cocaine (GO:0048148)2.99467338
115cellular potassium ion transport (GO:0071804)2.98787846
116potassium ion transmembrane transport (GO:0071805)2.98787846
117fear response (GO:0042596)2.98594887
118vesicle transport along microtubule (GO:0047496)2.97275455
119regulation of ARF protein signal transduction (GO:0032012)2.96478004
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96391467
121mechanosensory behavior (GO:0007638)2.96166290
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94394845
123regulation of synapse maturation (GO:0090128)2.93087276
124cyclic nucleotide catabolic process (GO:0009214)2.88741225
125calcium ion-dependent exocytosis (GO:0017156)2.86850876
126regulation of dopamine metabolic process (GO:0042053)2.86776830
127regulation of catecholamine metabolic process (GO:0042069)2.86776830
128cerebellar granule cell differentiation (GO:0021707)2.86634647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07091444
2GBX2_23144817_ChIP-Seq_PC3_Human3.70295219
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14458072
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14415775
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99828108
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72982329
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72982329
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.69810346
9DROSHA_22980978_ChIP-Seq_HELA_Human2.64086570
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63742962
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.63378626
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63242755
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57792699
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.52254483
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49764349
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49525263
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49301631
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43956258
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27540516
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.26070495
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.22065523
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18581425
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.13460919
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04435651
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94697744
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94204202
27AR_21572438_ChIP-Seq_LNCaP_Human1.93465032
28VDR_22108803_ChIP-Seq_LS180_Human1.92447639
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88236509
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83843644
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82587302
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79653480
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73376805
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72202065
35TAF15_26573619_Chip-Seq_HEK293_Human1.67411734
36SMAD4_21799915_ChIP-Seq_A2780_Human1.62362708
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59260739
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.52469491
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.52087925
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48506262
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42773563
42* P300_19829295_ChIP-Seq_ESCs_Human1.35617816
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.34789995
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34371914
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.31811063
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.30892218
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28350517
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27194671
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25597804
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25472040
51STAT3_23295773_ChIP-Seq_U87_Human1.23711893
52AR_25329375_ChIP-Seq_VCAP_Human1.22926809
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22884283
54AR_19668381_ChIP-Seq_PC3_Human1.20370956
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.19643906
56ZNF274_21170338_ChIP-Seq_K562_Hela1.18452668
57* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17250816
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15869078
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15746579
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15371799
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14847861
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.14844741
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14751853
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13202346
65ER_23166858_ChIP-Seq_MCF-7_Human1.13085711
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12964119
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.12102004
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.11556484
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11484998
70TCF4_23295773_ChIP-Seq_U87_Human1.11483426
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10272705
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10101673
73* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09810959
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09202901
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08521209
76AHR_22903824_ChIP-Seq_MCF-7_Human1.06579878
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.06519256
78BCAT_22108803_ChIP-Seq_LS180_Human1.05902443
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05823204
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03773406
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03484931
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03047656
83RNF2_27304074_Chip-Seq_NSC_Mouse1.03031828
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02773188
85TP53_16413492_ChIP-PET_HCT116_Human1.02756810
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02687781
87CBP_20019798_ChIP-Seq_JUKART_Human1.02687781
88IGF1R_20145208_ChIP-Seq_DFB_Human1.02630363
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.01160526
90* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99743477
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.99592653
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.99269579
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98894732
94KDM2B_26808549_Chip-Seq_K562_Human0.98873726
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98279477
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97800088
97* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96851412
98RUNX2_22187159_ChIP-Seq_PCA_Human0.96521447
99TP53_22573176_ChIP-Seq_HFKS_Human0.96036383
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95117370
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94644587
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94364496
103KDM2B_26808549_Chip-Seq_REH_Human0.94311693
104SMAD4_21741376_ChIP-Seq_EPCs_Human0.93713995
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93460589
106FUS_26573619_Chip-Seq_HEK293_Human0.92968980
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92602569
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92602569
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.92526715
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92482486
111RXR_22108803_ChIP-Seq_LS180_Human0.91818434
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91400106
113* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90752063
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90451761
115* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89261660
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.88019070
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87025018
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86879599
119JUN_21703547_ChIP-Seq_K562_Human0.85777348
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85655903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.14476068
2MP0003880_abnormal_central_pattern5.10361723
3MP0003635_abnormal_synaptic_transmissio4.32521766
4MP0004270_analgesia4.00778946
5MP0009745_abnormal_behavioral_response3.58471228
6MP0002063_abnormal_learning/memory/cond3.49260295
7MP0002064_seizures3.23975974
8MP0002822_catalepsy3.15037738
9MP0001968_abnormal_touch/_nociception3.08514381
10MP0009046_muscle_twitch3.04583238
11MP0005423_abnormal_somatic_nervous3.01920245
12MP0002572_abnormal_emotion/affect_behav2.91524117
13MP0001486_abnormal_startle_reflex2.79793844
14MP0002734_abnormal_mechanical_nocicepti2.67604234
15MP0002272_abnormal_nervous_system2.57968229
16MP0001501_abnormal_sleep_pattern2.31353438
17MP0002736_abnormal_nociception_after2.23545995
18MP0009780_abnormal_chondrocyte_physiolo2.20203602
19MP0001440_abnormal_grooming_behavior2.10199303
20MP0002735_abnormal_chemical_nociception2.09357773
21MP0002733_abnormal_thermal_nociception1.93615149
22MP0001970_abnormal_pain_threshold1.92624073
23MP0002067_abnormal_sensory_capabilities1.88639701
24MP0003879_abnormal_hair_cell1.88158833
25MP0008569_lethality_at_weaning1.84266910
26MP0004811_abnormal_neuron_physiology1.79771168
27MP0002557_abnormal_social/conspecific_i1.79193992
28MP0004924_abnormal_behavior1.79113577
29MP0005386_behavior/neurological_phenoty1.79113577
30MP0005646_abnormal_pituitary_gland1.78742099
31MP0000778_abnormal_nervous_system1.78431297
32MP0008877_abnormal_DNA_methylation1.75723193
33MP0003329_amyloid_beta_deposits1.72184003
34MP0004858_abnormal_nervous_system1.67180367
35MP0002184_abnormal_innervation1.66277388
36MP0002909_abnormal_adrenal_gland1.63953186
37MP0000955_abnormal_spinal_cord1.48453948
38MP0003633_abnormal_nervous_system1.42569668
39MP0001984_abnormal_olfaction1.41149925
40MP0004885_abnormal_endolymph1.40982834
41MP0002066_abnormal_motor_capabilities/c1.40025856
42MP0002882_abnormal_neuron_morphology1.39024869
43MP0005645_abnormal_hypothalamus_physiol1.38499127
44MP0000569_abnormal_digit_pigmentation1.36316133
45MP0001529_abnormal_vocalization1.35845504
46MP0003787_abnormal_imprinting1.34779786
47MP0006276_abnormal_autonomic_nervous1.33472900
48MP0001905_abnormal_dopamine_level1.30892761
49MP0001188_hyperpigmentation1.26357333
50MP0001502_abnormal_circadian_rhythm1.23299238
51MP0003631_nervous_system_phenotype1.17355993
52MP0001986_abnormal_taste_sensitivity1.11857559
53MP0008872_abnormal_physiological_respon1.07484248
54MP0002152_abnormal_brain_morphology1.07394484
55MP0004142_abnormal_muscle_tone1.05088423
56MP0004147_increased_porphyrin_level1.04567083
57MP0003195_calcinosis1.03340965
58MP0001177_atelectasis1.03180773
59MP0003075_altered_response_to0.99144102
60MP0003136_yellow_coat_color0.98227470
61MP0008874_decreased_physiological_sensi0.97110302
62MP0004742_abnormal_vestibular_system0.94203765
63MP0002069_abnormal_eating/drinking_beha0.92989340
64MP0005409_darkened_coat_color0.92830721
65MP0006072_abnormal_retinal_apoptosis0.90635118
66MP0004043_abnormal_pH_regulation0.90497181
67MP0008961_abnormal_basal_metabolism0.90373161
68MP0003690_abnormal_glial_cell0.89733801
69MP0002229_neurodegeneration0.89578585
70MP0005551_abnormal_eye_electrophysiolog0.88559682
71MP0010386_abnormal_urinary_bladder0.88213621
72MP0005253_abnormal_eye_physiology0.86274415
73MP0005535_abnormal_body_temperature0.85232679
74MP0001963_abnormal_hearing_physiology0.85055218
75MP0003123_paternal_imprinting0.84263205
76MP0004133_heterotaxia0.84130200
77MP0000920_abnormal_myelination0.83017644
78MP0003121_genomic_imprinting0.81678951
79MP0000751_myopathy0.80315436
80MP0003122_maternal_imprinting0.79398321
81MP0003283_abnormal_digestive_organ0.79386657
82MP0004085_abnormal_heartbeat0.78834491
83MP0000631_abnormal_neuroendocrine_gland0.78000706
84MP0003632_abnormal_nervous_system0.74657832
85MP0003634_abnormal_glial_cell0.74297711
86MP0002102_abnormal_ear_morphology0.74224428
87MP0004145_abnormal_muscle_electrophysio0.72323284
88MP0000604_amyloidosis0.72260490
89MP0002090_abnormal_vision0.72242731
90MP0005499_abnormal_olfactory_system0.71700561
91MP0005394_taste/olfaction_phenotype0.71700561
92MP0001485_abnormal_pinna_reflex0.71480509
93MP0001664_abnormal_digestion0.70692920
94MP0000427_abnormal_hair_cycle0.69590640
95MP0000372_irregular_coat_pigmentation0.68643009
96MP0008875_abnormal_xenobiotic_pharmacok0.68244875
97MP0004510_myositis0.67995135
98MP0002752_abnormal_somatic_nervous0.67991440
99MP0005167_abnormal_blood-brain_barrier0.65483161
100MP0000013_abnormal_adipose_tissue0.65179542
101MP0000026_abnormal_inner_ear0.63246517
102MP0003172_abnormal_lysosome_physiology0.59605443
103MP0004484_altered_response_of0.59476664
104MP0003137_abnormal_impulse_conducting0.56522898
105MP0004215_abnormal_myocardial_fiber0.55234975
106MP0003183_abnormal_peptide_metabolism0.53340450
107MP0002638_abnormal_pupillary_reflex0.53277208
108MP0002653_abnormal_ependyma_morphology0.53024718
109MP0000230_abnormal_systemic_arterial0.52256677
110MP0010769_abnormal_survival0.51815917
111MP0005623_abnormal_meninges_morphology0.51481625
112MP0004130_abnormal_muscle_cell0.51359337
113MP0002837_dystrophic_cardiac_calcinosis0.51133698
114MP0001943_abnormal_respiration0.51067639
115MP0002876_abnormal_thyroid_physiology0.50851050
116MP0005084_abnormal_gallbladder_morpholo0.50721523
117MP0000639_abnormal_adrenal_gland0.49820559
118MP0003011_delayed_dark_adaptation0.49693378
119MP0003861_abnormal_nervous_system0.49667711
120MP0002082_postnatal_lethality0.49543142
121MP0010770_preweaning_lethality0.49543142
122MP0010768_mortality/aging0.48571662
123MP0003956_abnormal_body_size0.47742625

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.42918946
2Myokymia (HP:0002411)7.54171086
3Focal seizures (HP:0007359)6.05403124
4Epileptic encephalopathy (HP:0200134)5.37693617
5Visual hallucinations (HP:0002367)5.22266289
6Febrile seizures (HP:0002373)4.67946878
7Atonic seizures (HP:0010819)4.45116496
8Progressive cerebellar ataxia (HP:0002073)4.22797819
9Absence seizures (HP:0002121)4.18675226
10Broad-based gait (HP:0002136)4.14048625
11Generalized tonic-clonic seizures (HP:0002069)4.10263046
12Poor eye contact (HP:0000817)3.97171932
13Dialeptic seizures (HP:0011146)3.85617547
14Hyperventilation (HP:0002883)3.76028937
15Ankle clonus (HP:0011448)3.69837808
16Action tremor (HP:0002345)3.66205862
17Gaze-evoked nystagmus (HP:0000640)3.62956526
18Papilledema (HP:0001085)3.60457842
19Impaired vibration sensation in the lower limbs (HP:0002166)3.58147648
20Supranuclear gaze palsy (HP:0000605)3.51907870
21Impaired social interactions (HP:0000735)3.43858596
22Abnormal social behavior (HP:0012433)3.43858596
23Urinary bladder sphincter dysfunction (HP:0002839)3.42145666
24Depression (HP:0000716)3.21478231
25Mutism (HP:0002300)3.14967176
26Dysdiadochokinesis (HP:0002075)3.13834884
27Dysmetria (HP:0001310)3.13671683
28Postural instability (HP:0002172)3.11870556
29Anxiety (HP:0000739)3.02498165
30Amblyopia (HP:0000646)3.01568814
31Truncal ataxia (HP:0002078)3.01200381
32Dyskinesia (HP:0100660)2.93465385
33Abnormal eating behavior (HP:0100738)2.88859136
34Diminished movement (HP:0002374)2.85902680
35Drooling (HP:0002307)2.85341588
36Excessive salivation (HP:0003781)2.85341588
37Torticollis (HP:0000473)2.83704504
38Urinary urgency (HP:0000012)2.82653538
39Congenital stationary night blindness (HP:0007642)2.82046100
40Impaired smooth pursuit (HP:0007772)2.80417286
41Fetal akinesia sequence (HP:0001989)2.77362742
42Hypokinesia (HP:0002375)2.74849248
43Stereotypic behavior (HP:0000733)2.74300173
44Genetic anticipation (HP:0003743)2.71662391
45Spastic gait (HP:0002064)2.71072587
46Morphological abnormality of the pyramidal tract (HP:0002062)2.68886065
47Hemiparesis (HP:0001269)2.64709294
48Absent speech (HP:0001344)2.64000934
49Focal dystonia (HP:0004373)2.60885112
50Scanning speech (HP:0002168)2.60333414
51Epileptiform EEG discharges (HP:0011182)2.58411138
52Neurofibrillary tangles (HP:0002185)2.57997306
53Abnormality of binocular vision (HP:0011514)2.54848266
54Diplopia (HP:0000651)2.54848266
55Bradykinesia (HP:0002067)2.54312990
56Intention tremor (HP:0002080)2.49899258
57Impaired vibratory sensation (HP:0002495)2.49694979
58Megalencephaly (HP:0001355)2.49527189
59Progressive inability to walk (HP:0002505)2.47767625
60Cerebral inclusion bodies (HP:0100314)2.46465514
61Gait imbalance (HP:0002141)2.45083072
62EEG with generalized epileptiform discharges (HP:0011198)2.44527525
63Inability to walk (HP:0002540)2.44424437
64Molar tooth sign on MRI (HP:0002419)2.41285792
65Abnormality of midbrain morphology (HP:0002418)2.41285792
66Hemiplegia (HP:0002301)2.39517115
67Abnormality of ocular smooth pursuit (HP:0000617)2.38912501
68Limb dystonia (HP:0002451)2.37919906
69Abnormality of the lower motor neuron (HP:0002366)2.33609493
70Generalized myoclonic seizures (HP:0002123)2.33366381
71Status epilepticus (HP:0002133)2.30977264
72Craniofacial dystonia (HP:0012179)2.30357142
73Obstructive sleep apnea (HP:0002870)2.30274707
74Hypsarrhythmia (HP:0002521)2.30231220
75Lower limb muscle weakness (HP:0007340)2.29444341
76Blue irides (HP:0000635)2.26858261
77Type II lissencephaly (HP:0007260)2.25135776
78Cerebral hypomyelination (HP:0006808)2.24574477
79Lower limb amyotrophy (HP:0007210)2.20813959
80Decreased central vision (HP:0007663)2.19865803
81Abnormality of the corticospinal tract (HP:0002492)2.18788246
82Delusions (HP:0000746)2.15856846
83Ventricular fibrillation (HP:0001663)2.15564150
84Pancreatic cysts (HP:0001737)2.13717609
85Inappropriate behavior (HP:0000719)2.13269599
86Insidious onset (HP:0003587)2.13108105
87Termporal pattern (HP:0011008)2.13108105
88Nephronophthisis (HP:0000090)2.11877521
89Pancreatic fibrosis (HP:0100732)2.11472556
90Annular pancreas (HP:0001734)2.11448303
91Muscular hypotonia of the trunk (HP:0008936)2.10074329
92Dysmetric saccades (HP:0000641)2.07155660
93Polyphagia (HP:0002591)2.04368589
94Medial flaring of the eyebrow (HP:0010747)2.03236950
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03144660
96Protruding tongue (HP:0010808)2.02648770
97True hermaphroditism (HP:0010459)1.97775734
98Incomplete penetrance (HP:0003829)1.97272326
99Abnormality of salivation (HP:0100755)1.97194642
100Chronic hepatic failure (HP:0100626)1.97190332
101Gait ataxia (HP:0002066)1.94754408
102Pointed chin (HP:0000307)1.94648502
103Generalized hypopigmentation of hair (HP:0011358)1.92312413
104Ankyloglossia (HP:0010296)1.91557818
105Retinal dysplasia (HP:0007973)1.89936379
106Abnormal EKG (HP:0003115)1.89125405
107Clonus (HP:0002169)1.88468066
108Agitation (HP:0000713)1.85009566
109Clumsiness (HP:0002312)1.84884584
110Pheochromocytoma (HP:0002666)1.84625239
111Rigidity (HP:0002063)1.82263000
112Akinesia (HP:0002304)1.82007073
113Hypothermia (HP:0002045)1.80305092
114Spastic tetraparesis (HP:0001285)1.80270697
115Congenital primary aphakia (HP:0007707)1.80178904
116Abnormality of saccadic eye movements (HP:0000570)1.79294520
117Insomnia (HP:0100785)1.79078432
118Abnormality of the periventricular white matter (HP:0002518)1.78460707
119Aplasia involving bones of the extremities (HP:0009825)1.77778359
120Aplasia involving bones of the upper limbs (HP:0009823)1.77778359
121Aplasia of the phalanges of the hand (HP:0009802)1.77778359
122Bundle branch block (HP:0011710)1.76813560
123Resting tremor (HP:0002322)1.75828097
124Neuronal loss in central nervous system (HP:0002529)1.74799271
125Sleep apnea (HP:0010535)1.73716236
126Abnormality of the renal medulla (HP:0100957)1.72278039
127Oligodactyly (hands) (HP:0001180)1.70819201
128Spastic tetraplegia (HP:0002510)1.70475370
129Abnormality of the labia minora (HP:0012880)1.69228274
130CNS hypomyelination (HP:0003429)1.67660096
131Nephrogenic diabetes insipidus (HP:0009806)1.65642070
132Abnormal drinking behavior (HP:0030082)1.65584368
133Polydipsia (HP:0001959)1.65584368
134Intellectual disability, severe (HP:0010864)1.62469685
135Abolished electroretinogram (ERG) (HP:0000550)1.62191275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.21159231
2NTRK34.24325216
3MAP3K93.99309772
4MARK13.23380300
5DAPK23.14874951
6FRK2.80712540
7MAP3K42.78669130
8MINK12.48884961
9MAP2K72.46882107
10PRKD32.32583658
11PAK62.26024028
12NTRK22.20249784
13RIPK42.05661256
14KSR21.97718466
15NTRK11.97246509
16CAMKK11.93531031
17CASK1.93186649
18DAPK11.85785914
19MAPKAPK51.85262949
20MAP3K121.74673667
21MAP2K41.73980997
22TNIK1.70663130
23SIK21.59956775
24CDK51.59813992
25KSR11.57736302
26PRPF4B1.49284291
27MAP4K21.45348990
28TLK11.44959077
29PLK21.40878203
30MAPK131.36600104
31CDK191.35640548
32MAP3K131.34365301
33STK391.34065488
34WNK41.29347513
35INSRR1.25954002
36STK381.25314750
37GRK51.24933432
38PRKCG1.15781298
39TYRO31.15573614
40NME11.14721288
41MAP3K21.14689433
42FES1.14506958
43ARAF1.11388878
44TAOK11.09704083
45CSNK1G31.06340282
46ADRBK21.06108982
47CAMK11.03096103
48CAMKK21.02573941
49MAP2K61.02253348
50UHMK11.00030215
51PNCK0.97913653
52BMPR20.96530800
53CAMK2A0.96082336
54BMPR1B0.93306420
55STK110.93213863
56MAP3K110.91861917
57CSNK1G10.90203567
58SGK2230.88347082
59SGK4940.88347082
60CDK180.86875218
61CDK150.85707449
62LATS20.84590247
63PHKG10.83296928
64PHKG20.83296928
65PRKCH0.81054448
66RAF10.80908233
67CDK140.79489925
68SGK20.78195820
69CAMK2B0.77828328
70GRK10.77340193
71OXSR10.77258545
72SGK10.77002497
73CDK11A0.74507474
74RET0.73752381
75ALK0.73565948
76CCNB10.73447341
77MARK20.71947922
78CSNK1G20.69922316
79PAK30.68397565
80SGK30.67247984
81PTK2B0.66934428
82PDK10.66720044
83PINK10.63647155
84NEK60.63602296
85ADRBK10.63065475
86PDPK10.60090621
87DYRK1A0.59732476
88TRIM280.57058981
89ACVR1B0.56632462
90TNK20.56036930
91ZAK0.54098778
92NUAK10.53594210
93MAP3K10.51643242
94DYRK20.50016040
95LMTK20.49530673
96PRKCZ0.49303871
97PRKCE0.48331366
98RPS6KA30.48142140
99DAPK30.48036908
100MAP3K70.47112834
101CAMK40.46984642
102FYN0.46833210
103BCR0.46386505
104CSNK1D0.44136064
105PRKACA0.43912077
106CAMK1G0.43298501
107CDC42BPA0.42916934
108BUB10.42604201
109FGR0.41729898
110MAPK100.41011124
111BRSK10.40247205
112MAP3K60.40131645
113CAMK1D0.39554868
114CAMK2D0.39318812
115FGFR20.37997879
116CSNK1A10.37501393
117CAMK2G0.36092513
118MAPK120.34852700
119DMPK0.34660229
120SIK30.34183194
121MAP2K10.34106734
122PKN10.32624350
123WNK30.32257905
124TAOK20.32046318
125RIPK10.31999331
126CSNK1A1L0.31635726
127AKT30.30855150
128PRKCB0.30705942
129PRKCA0.26585043

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68950034
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20556449
3Olfactory transduction_Homo sapiens_hsa047402.90556256
4Circadian entrainment_Homo sapiens_hsa047132.79415764
5Glutamatergic synapse_Homo sapiens_hsa047242.71104235
6Long-term potentiation_Homo sapiens_hsa047202.68765492
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68155131
8GABAergic synapse_Homo sapiens_hsa047272.66644184
9Morphine addiction_Homo sapiens_hsa050322.61795115
10Amphetamine addiction_Homo sapiens_hsa050312.55618897
11Salivary secretion_Homo sapiens_hsa049702.24914106
12Dopaminergic synapse_Homo sapiens_hsa047282.19559544
13Insulin secretion_Homo sapiens_hsa049112.09458141
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07372274
15Cholinergic synapse_Homo sapiens_hsa047252.01808188
16Gastric acid secretion_Homo sapiens_hsa049711.96023476
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94874867
18Cocaine addiction_Homo sapiens_hsa050301.76597241
19Oxytocin signaling pathway_Homo sapiens_hsa049211.72395859
20Renin secretion_Homo sapiens_hsa049241.71039546
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68931963
22Serotonergic synapse_Homo sapiens_hsa047261.66738978
23Calcium signaling pathway_Homo sapiens_hsa040201.65670927
24Taste transduction_Homo sapiens_hsa047421.64645194
25Long-term depression_Homo sapiens_hsa047301.62484554
26GnRH signaling pathway_Homo sapiens_hsa049121.48325543
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34975898
28Gap junction_Homo sapiens_hsa045401.34693197
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32085972
30cAMP signaling pathway_Homo sapiens_hsa040241.31806559
31Nitrogen metabolism_Homo sapiens_hsa009101.28673777
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25365600
33Glioma_Homo sapiens_hsa052141.21575497
34Type II diabetes mellitus_Homo sapiens_hsa049301.20227425
35Axon guidance_Homo sapiens_hsa043601.17623446
36Collecting duct acid secretion_Homo sapiens_hsa049661.17569298
37Oxidative phosphorylation_Homo sapiens_hsa001901.17542913
38Estrogen signaling pathway_Homo sapiens_hsa049151.15743684
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15004330
40Vitamin B6 metabolism_Homo sapiens_hsa007501.14514532
41Parkinsons disease_Homo sapiens_hsa050121.13636603
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13598529
43ErbB signaling pathway_Homo sapiens_hsa040121.11533183
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09810735
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07128066
46Melanogenesis_Homo sapiens_hsa049161.07025463
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04922021
48Butanoate metabolism_Homo sapiens_hsa006501.03289344
49Linoleic acid metabolism_Homo sapiens_hsa005910.97341074
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97161870
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.95326797
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.88860342
53Pancreatic secretion_Homo sapiens_hsa049720.87676355
54Dorso-ventral axis formation_Homo sapiens_hsa043200.85822442
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85776525
56Phototransduction_Homo sapiens_hsa047440.85535987
57Alzheimers disease_Homo sapiens_hsa050100.82359119
58Cardiac muscle contraction_Homo sapiens_hsa042600.82117158
59Oocyte meiosis_Homo sapiens_hsa041140.81935560
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81261410
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79966022
62Ether lipid metabolism_Homo sapiens_hsa005650.75531630
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74816335
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74699504
65Choline metabolism in cancer_Homo sapiens_hsa052310.74215751
66MAPK signaling pathway_Homo sapiens_hsa040100.74136129
67Dilated cardiomyopathy_Homo sapiens_hsa054140.73622379
68Vibrio cholerae infection_Homo sapiens_hsa051100.73614164
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72350346
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66755502
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65839806
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64118004
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.64098877
74Ras signaling pathway_Homo sapiens_hsa040140.63287284
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62647971
76VEGF signaling pathway_Homo sapiens_hsa043700.62103882
77Rap1 signaling pathway_Homo sapiens_hsa040150.59888647
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59532713
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.59063863
80Tryptophan metabolism_Homo sapiens_hsa003800.56036987
81Type I diabetes mellitus_Homo sapiens_hsa049400.53957168
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53710340
83Alcoholism_Homo sapiens_hsa050340.52252898
84Glucagon signaling pathway_Homo sapiens_hsa049220.51451971
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51095463
86Selenocompound metabolism_Homo sapiens_hsa004500.49923498
87Circadian rhythm_Homo sapiens_hsa047100.47705677
88Endocytosis_Homo sapiens_hsa041440.47598765
89mTOR signaling pathway_Homo sapiens_hsa041500.47590327
90Non-small cell lung cancer_Homo sapiens_hsa052230.47481930
91African trypanosomiasis_Homo sapiens_hsa051430.47472595
92Endometrial cancer_Homo sapiens_hsa052130.47213425
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.46565170
94Fatty acid biosynthesis_Homo sapiens_hsa000610.45606020
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45396858
96Inositol phosphate metabolism_Homo sapiens_hsa005620.45314675
97Wnt signaling pathway_Homo sapiens_hsa043100.44718210
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44383772
99Bile secretion_Homo sapiens_hsa049760.43881607
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43393444
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43168289
102Chemokine signaling pathway_Homo sapiens_hsa040620.42605880
103Ovarian steroidogenesis_Homo sapiens_hsa049130.41699751
104beta-Alanine metabolism_Homo sapiens_hsa004100.41291398
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40595569
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40448779
107Prion diseases_Homo sapiens_hsa050200.39653971
108Renal cell carcinoma_Homo sapiens_hsa052110.39291338
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38455379
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37248059
111Huntingtons disease_Homo sapiens_hsa050160.37243707
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36801438
113Mineral absorption_Homo sapiens_hsa049780.34846876
114Insulin signaling pathway_Homo sapiens_hsa049100.34506609
115Regulation of autophagy_Homo sapiens_hsa041400.33705428
116ABC transporters_Homo sapiens_hsa020100.32380287
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.30733330
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30546001
119Peroxisome_Homo sapiens_hsa041460.30535325
120Glycerolipid metabolism_Homo sapiens_hsa005610.29703191
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29659733
122Sphingolipid metabolism_Homo sapiens_hsa006000.29017905
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28009784
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27528626
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27052068
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26354160
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.23222616

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