GPR27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.45800882
2neuron cell-cell adhesion (GO:0007158)5.36041626
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18190630
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.11835141
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84143503
6positive regulation by symbiont of host defense response (GO:0052509)4.83814245
7modulation by symbiont of host defense response (GO:0052031)4.83814245
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.83814245
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.83814245
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.83814245
11modulation by symbiont of host immune response (GO:0052553)4.83814245
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.82985090
13protein localization to synapse (GO:0035418)4.80653200
14regulation of glutamate receptor signaling pathway (GO:1900449)4.76368212
15synaptic vesicle exocytosis (GO:0016079)4.74509089
16locomotory exploration behavior (GO:0035641)4.69450275
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.64642436
18leukocyte migration involved in inflammatory response (GO:0002523)4.62921741
19regulation of synaptic vesicle exocytosis (GO:2000300)4.31225546
20dendritic spine morphogenesis (GO:0060997)4.30729385
21exploration behavior (GO:0035640)4.29035381
22neuron recognition (GO:0008038)4.28702885
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24216846
24glutamate receptor signaling pathway (GO:0007215)4.22364156
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.13355987
26negative regulation of cell killing (GO:0031342)4.12238838
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.12238838
28synaptic vesicle maturation (GO:0016188)4.11515623
29layer formation in cerebral cortex (GO:0021819)4.00802176
30postsynaptic membrane organization (GO:0001941)3.99230078
31synaptic transmission, glutamatergic (GO:0035249)3.99217455
32macrophage activation involved in immune response (GO:0002281)3.98804079
33glutamate secretion (GO:0014047)3.94994179
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93545737
35presynaptic membrane assembly (GO:0097105)3.91614398
36neuron-neuron synaptic transmission (GO:0007270)3.90959118
37regulation of synaptic vesicle transport (GO:1902803)3.84153667
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.82438021
39axonal fasciculation (GO:0007413)3.81827641
40microglial cell activation (GO:0001774)3.81826723
41neurotransmitter-gated ion channel clustering (GO:0072578)3.80618534
42activated T cell proliferation (GO:0050798)3.75712895
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.72621731
44regulation of synapse structural plasticity (GO:0051823)3.72039572
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71394177
46regulation of neuronal synaptic plasticity (GO:0048168)3.69479329
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.68772521
48neurotransmitter secretion (GO:0007269)3.67836461
49response to host immune response (GO:0052572)3.63870690
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63870690
51response to peptidoglycan (GO:0032494)3.62202151
52neuronal action potential propagation (GO:0019227)3.59883085
53detection of molecule of bacterial origin (GO:0032490)3.59086947
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58851727
55respiratory burst (GO:0045730)3.57721212
56positive regulation of synapse maturation (GO:0090129)3.57162730
57presynaptic membrane organization (GO:0097090)3.54058396
58neutrophil activation involved in immune response (GO:0002283)3.53551458
59detection of calcium ion (GO:0005513)3.52014718
60cell migration in hindbrain (GO:0021535)3.47643806
61positive regulation of membrane potential (GO:0045838)3.47112457
62regulation of postsynaptic membrane potential (GO:0060078)3.45491983
63response to histamine (GO:0034776)3.42785976
64regulation of dendritic spine morphogenesis (GO:0061001)3.42039383
65proline transport (GO:0015824)3.39742638
66innervation (GO:0060384)3.39692864
67detection of other organism (GO:0098543)3.37737790
68transmission of nerve impulse (GO:0019226)3.35811273
69synaptic vesicle endocytosis (GO:0048488)3.34646436
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.33422472
71long-term memory (GO:0007616)3.33192754
72leukocyte aggregation (GO:0070486)3.32232264
73pyrimidine nucleobase catabolic process (GO:0006208)3.31838312
74regulation of vesicle fusion (GO:0031338)3.31542467
75macrophage activation (GO:0042116)3.29956577
76synapse assembly (GO:0007416)3.29913402
77neutrophil activation (GO:0042119)3.29682034
78neutrophil mediated immunity (GO:0002446)3.27633983
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22207530
80dendrite morphogenesis (GO:0048813)3.21748048
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20776899
82positive regulation of synapse assembly (GO:0051965)3.19736798
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19421225
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19174412
85negative regulation of microtubule polymerization (GO:0031115)3.18057243
86negative regulation of lymphocyte mediated immunity (GO:0002707)3.17043949
87central nervous system projection neuron axonogenesis (GO:0021952)3.16654133
88regulation of synaptic transmission, glutamatergic (GO:0051966)3.14628646
89neurofilament cytoskeleton organization (GO:0060052)3.12741836
90cellular extravasation (GO:0045123)3.11776188
91dendritic spine organization (GO:0097061)3.11183285
92long-term synaptic potentiation (GO:0060291)3.10888169
93startle response (GO:0001964)3.10391631
94regulation of synaptic plasticity (GO:0048167)3.08962389
95behavioral defense response (GO:0002209)3.08853476
96behavioral fear response (GO:0001662)3.08853476
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08437144
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08365725
99adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07115540
100detection of external biotic stimulus (GO:0098581)3.06384846
101positive regulation of neurotransmitter secretion (GO:0001956)3.04505626
102neurotransmitter transport (GO:0006836)3.03601911
103fear response (GO:0042596)3.01586766
104nucleobase catabolic process (GO:0046113)3.00790507
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00426485
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99975758
107regulation of glutamate secretion (GO:0014048)2.99728177
108cerebellar granule cell differentiation (GO:0021707)2.98642710
109detection of bacterium (GO:0016045)2.97799113
110gamma-aminobutyric acid transport (GO:0015812)2.95434453
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.95274221
112learning (GO:0007612)2.92683645
113female mating behavior (GO:0060180)2.92033463
114regulation of neurotransmitter secretion (GO:0046928)2.91716697
115negative regulation of phagocytosis (GO:0050765)2.91663591
116regulation of synapse maturation (GO:0090128)2.91570863
117establishment of mitochondrion localization (GO:0051654)2.91509935
118cochlea development (GO:0090102)2.91309757
119auditory behavior (GO:0031223)2.91201369
120cerebellar Purkinje cell differentiation (GO:0021702)2.90496345
121membrane depolarization (GO:0051899)2.90374811
122synapse organization (GO:0050808)2.89686555
123regulation of female receptivity (GO:0045924)2.89467070
124production of molecular mediator involved in inflammatory response (GO:0002532)2.88694394
125activation of protein kinase A activity (GO:0034199)2.88689841
126response to host (GO:0075136)2.88425963
127response to host defenses (GO:0052200)2.88425963
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88425963
129negative regulation of dendrite development (GO:2000171)2.88229455
130inositol phosphate catabolic process (GO:0071545)2.87892492
131regulation of dendritic spine development (GO:0060998)2.87812914
132regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85200849
133dendrite development (GO:0016358)2.85200772
134myeloid leukocyte mediated immunity (GO:0002444)2.85187933
135behavioral response to cocaine (GO:0048148)2.84712355
136membrane hyperpolarization (GO:0060081)2.84643493
137regulation of synaptic transmission, GABAergic (GO:0032228)2.81944940
138social behavior (GO:0035176)2.81736245
139intraspecies interaction between organisms (GO:0051703)2.81736245
140positive regulation of dendritic spine development (GO:0060999)2.81460173
141dopamine receptor signaling pathway (GO:0007212)2.79649762
142positive regulation of neurotransmitter transport (GO:0051590)2.78978902
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78728964
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.78728964
145regulation of translation, ncRNA-mediated (GO:0045974)2.78728964
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78560736
147negative regulation of cAMP-mediated signaling (GO:0043951)2.77898813
148adaptation of signaling pathway (GO:0023058)2.76783505
149detection of biotic stimulus (GO:0009595)2.76339341
150negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.74734500
151regulation of regulated secretory pathway (GO:1903305)2.74226231
152granulocyte activation (GO:0036230)2.70449202
153L-amino acid import (GO:0043092)2.67871594
154regulation of ARF protein signal transduction (GO:0032012)2.67629980
155mitochondrion transport along microtubule (GO:0047497)2.66521777
156establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66521777
157negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65869210
158negative regulation of B cell mediated immunity (GO:0002713)2.65869210
159negative regulation of interleukin-12 production (GO:0032695)2.65223137
160positive regulation of mast cell activation (GO:0033005)2.63946327
161negative regulation of protein oligomerization (GO:0032460)2.61419871
162epithelial cell fate commitment (GO:0072148)2.61240252
163negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60253300
164negative regulation of leukocyte mediated immunity (GO:0002704)2.60241551
165phagosome maturation (GO:0090382)2.55118481
166neutrophil chemotaxis (GO:0030593)2.54724182
167phosphorylated carbohydrate dephosphorylation (GO:0046838)2.54226752
168inositol phosphate dephosphorylation (GO:0046855)2.54226752
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.53970944
170regulation of interferon-beta biosynthetic process (GO:0045357)2.51970815
171myeloid cell activation involved in immune response (GO:0002275)2.50578951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.15754266
2GBX2_23144817_ChIP-Seq_PC3_Human3.84972586
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08876537
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02965801
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94484558
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75208396
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.71522193
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59668454
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58101448
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51714031
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51714031
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49880750
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42979274
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39364287
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35459261
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34896842
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.23260173
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.22953830
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.21008974
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20407985
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18627633
22TAF15_26573619_Chip-Seq_HEK293_Human2.13514795
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.12053468
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11984039
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11585565
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00855452
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98303309
28DROSHA_22980978_ChIP-Seq_HELA_Human1.89195765
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86657853
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78366173
31SMAD4_21799915_ChIP-Seq_A2780_Human1.76219302
32P300_19829295_ChIP-Seq_ESCs_Human1.71397556
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68905249
34IGF1R_20145208_ChIP-Seq_DFB_Human1.65431541
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63556730
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.62293973
37AR_21572438_ChIP-Seq_LNCaP_Human1.61674257
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60428017
39ZNF274_21170338_ChIP-Seq_K562_Hela1.56742727
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55534159
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54698763
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52999672
43VDR_22108803_ChIP-Seq_LS180_Human1.52012241
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.51811630
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51465840
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51146285
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47607489
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44031615
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42521627
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.42363309
51RNF2_27304074_Chip-Seq_NSC_Mouse1.42258531
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39236950
53FUS_26573619_Chip-Seq_HEK293_Human1.38840196
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.37091952
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35707629
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.35531103
57AR_25329375_ChIP-Seq_VCAP_Human1.34984999
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.33902091
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32030849
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31490216
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30411079
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.28832822
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25318072
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.24901763
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24459053
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23924604
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21813427
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21792726
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21047442
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.19788080
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18843707
72STAT3_23295773_ChIP-Seq_U87_Human1.18464496
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.17001960
74RUNX2_22187159_ChIP-Seq_PCA_Human1.15725233
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13603026
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12975828
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12956855
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12951277
79* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11578822
80AR_19668381_ChIP-Seq_PC3_Human1.11025187
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10658880
82AHR_22903824_ChIP-Seq_MCF-7_Human1.10608601
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10046445
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.09329474
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08838486
86TCF4_23295773_ChIP-Seq_U87_Human1.07429044
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06429847
88JUN_21703547_ChIP-Seq_K562_Human1.05463640
89KDM2B_26808549_Chip-Seq_DND41_Human1.04928988
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.04530475
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03940160
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03940160
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02951836
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02906365
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.01522395
96ER_23166858_ChIP-Seq_MCF-7_Human1.01316684
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01236178
98DPY_21335234_ChIP-Seq_ESCs_Mouse1.00925778
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00288278
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99671617
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99655961
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.98645321
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98184635
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97955150
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97289225
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96731751
107BCAT_22108803_ChIP-Seq_LS180_Human0.96664997
108* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96467723
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96382643
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96268336
111SPI1_23547873_ChIP-Seq_NB4_Human0.95526531
112KDM2B_26808549_Chip-Seq_K562_Human0.95386182
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.95224622
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.95195443
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93717544
116TP53_18474530_ChIP-ChIP_U2OS_Human0.92047439
117VDR_24763502_ChIP-Seq_THP-1_Human0.91969431
118KDM2B_26808549_Chip-Seq_REH_Human0.91421315
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91216835
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90656322
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90433246
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89836611
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89295243
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88372666
125TP53_22573176_ChIP-Seq_HFKS_Human0.87233207
126STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85761133
127EWS_26573619_Chip-Seq_HEK293_Human0.85703708
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85662399
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85600906
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84599699
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84301344
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83493351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.28267742
2MP0003880_abnormal_central_pattern4.82758931
3MP0003635_abnormal_synaptic_transmissio3.79730288
4MP0004270_analgesia3.61463505
5MP0002063_abnormal_learning/memory/cond3.24197976
6MP0003724_increased_susceptibility_to3.08313008
7MP0009745_abnormal_behavioral_response3.08293113
8MP0001968_abnormal_touch/_nociception2.79398557
9MP0002572_abnormal_emotion/affect_behav2.72422567
10MP0008877_abnormal_DNA_methylation2.69428054
11MP0002064_seizures2.67760003
12MP0002734_abnormal_mechanical_nocicepti2.58183332
13MP0002735_abnormal_chemical_nociception2.52239393
14MP0005423_abnormal_somatic_nervous2.46653245
15MP0006276_abnormal_autonomic_nervous2.40690975
16MP0002272_abnormal_nervous_system2.31693950
17MP0009046_muscle_twitch2.31446145
18MP0009780_abnormal_chondrocyte_physiolo2.29853079
19MP0002837_dystrophic_cardiac_calcinosis2.29257171
20MP0001486_abnormal_startle_reflex2.26548185
21MP0002736_abnormal_nociception_after2.22287924
22MP0000778_abnormal_nervous_system2.20846590
23MP0002277_abnormal_respiratory_mucosa2.17374503
24MP0001440_abnormal_grooming_behavior2.16817423
25MP0002822_catalepsy2.16464786
26MP0002184_abnormal_innervation2.11176519
27MP0002733_abnormal_thermal_nociception2.08310964
28MP0001501_abnormal_sleep_pattern1.99677754
29MP0001970_abnormal_pain_threshold1.93455272
30MP0002557_abnormal_social/conspecific_i1.88457144
31MP0001984_abnormal_olfaction1.86246318
32MP0001529_abnormal_vocalization1.85033226
33MP0002909_abnormal_adrenal_gland1.83356969
34MP0002067_abnormal_sensory_capabilities1.80227053
35MP0003122_maternal_imprinting1.73158715
36MP0004924_abnormal_behavior1.69797474
37MP0005386_behavior/neurological_phenoty1.69797474
38MP0003123_paternal_imprinting1.68977462
39MP0004811_abnormal_neuron_physiology1.65660146
40MP0001188_hyperpigmentation1.65610211
41MP0002653_abnormal_ependyma_morphology1.62639611
42MP0010386_abnormal_urinary_bladder1.62395504
43MP0005645_abnormal_hypothalamus_physiol1.61529971
44MP0003787_abnormal_imprinting1.54047799
45MP0003329_amyloid_beta_deposits1.52097706
46MP0005646_abnormal_pituitary_gland1.51686996
47MP0004858_abnormal_nervous_system1.50844298
48MP0000955_abnormal_spinal_cord1.49837709
49MP0003303_peritoneal_inflammation1.43591390
50MP0003690_abnormal_glial_cell1.42166201
51MP0005174_abnormal_tail_pigmentation1.41153171
52MP0002882_abnormal_neuron_morphology1.37039434
53MP0003879_abnormal_hair_cell1.35671151
54MP0002066_abnormal_motor_capabilities/c1.31134619
55MP0008569_lethality_at_weaning1.28901650
56MP0001905_abnormal_dopamine_level1.25041920
57MP0005248_abnormal_Harderian_gland1.22677455
58MP0005499_abnormal_olfactory_system1.22429592
59MP0005394_taste/olfaction_phenotype1.22429592
60MP0002163_abnormal_gland_morphology1.22261450
61MP0001502_abnormal_circadian_rhythm1.15863477
62MP0003436_decreased_susceptibility_to1.15537317
63MP0002132_abnormal_respiratory_system1.15288511
64MP0004885_abnormal_endolymph1.13638113
65MP0002152_abnormal_brain_morphology1.13079606
66MP0003938_abnormal_ear_development1.12809403
67MP0000631_abnormal_neuroendocrine_gland1.12543386
68MP0006292_abnormal_olfactory_placode1.11215207
69MP0003172_abnormal_lysosome_physiology1.10571127
70MP0005367_renal/urinary_system_phenotyp1.09735769
71MP0000516_abnormal_urinary_system1.09735769
72MP0002419_abnormal_innate_immunity1.08119908
73MP0001986_abnormal_taste_sensitivity1.07607917
74MP0000013_abnormal_adipose_tissue1.07279830
75MP0002638_abnormal_pupillary_reflex1.05109891
76MP0002102_abnormal_ear_morphology1.03820786
77MP0009379_abnormal_foot_pigmentation1.03138054
78MP0004142_abnormal_muscle_tone1.02516596
79MP0000751_myopathy1.02091117
80MP0002876_abnormal_thyroid_physiology1.00696928
81MP0006072_abnormal_retinal_apoptosis0.99690208
82MP0004085_abnormal_heartbeat0.99537239
83MP0003633_abnormal_nervous_system0.99533091
84MP0001944_abnormal_pancreas_morphology0.97847683
85MP0003283_abnormal_digestive_organ0.97095854
86MP0004145_abnormal_muscle_electrophysio0.96409081
87MP0002069_abnormal_eating/drinking_beha0.95186058
88MP0002234_abnormal_pharynx_morphology0.92629647
89MP0000678_abnormal_parathyroid_gland0.91202174
90MP0002928_abnormal_bile_duct0.90135629
91MP0004130_abnormal_muscle_cell0.87288015
92MP0004133_heterotaxia0.87123206
93MP0009278_abnormal_bone_marrow0.86875291
94MP0005409_darkened_coat_color0.86327644
95MP0008789_abnormal_olfactory_epithelium0.85776958
96MP0004510_myositis0.85435924
97MP0005187_abnormal_penis_morphology0.85131929
98MP0006035_abnormal_mitochondrial_morpho0.84943293
99MP0004742_abnormal_vestibular_system0.83985965
100MP0001963_abnormal_hearing_physiology0.82182672
101MP0005535_abnormal_body_temperature0.81741368
102MP0003631_nervous_system_phenotype0.81581747
103MP0004043_abnormal_pH_regulation0.80032040
104MP0004215_abnormal_myocardial_fiber0.79883907
105MP0002751_abnormal_autonomic_nervous0.79323409
106MP0002752_abnormal_somatic_nervous0.78998216
107MP0000427_abnormal_hair_cycle0.76703497
108MP0003632_abnormal_nervous_system0.76521224
109MP0003137_abnormal_impulse_conducting0.76141786
110MP0004484_altered_response_of0.75567210
111MP0002229_neurodegeneration0.74203216
112MP0003121_genomic_imprinting0.74012250
113MP0000569_abnormal_digit_pigmentation0.73475889
114MP0005377_hearing/vestibular/ear_phenot0.73179857
115MP0003878_abnormal_ear_physiology0.73179857
116MP0003861_abnormal_nervous_system0.72210048
117MP0003183_abnormal_peptide_metabolism0.71259318
118MP0003119_abnormal_digestive_system0.71031469
119MP0005025_abnormal_response_to0.70519400
120MP0005551_abnormal_eye_electrophysiolog0.69630051
121MP0003634_abnormal_glial_cell0.69138861
122MP0000026_abnormal_inner_ear0.68745982
123MP0005075_abnormal_melanosome_morpholog0.67795230
124MP0002420_abnormal_adaptive_immunity0.67633860
125MP0001819_abnormal_immune_cell0.66413136
126MP0000015_abnormal_ear_pigmentation0.65850822
127MP0001177_atelectasis0.65719011
128MP0002693_abnormal_pancreas_physiology0.65408127
129MP0005379_endocrine/exocrine_gland_phen0.65316226
130MP0001485_abnormal_pinna_reflex0.64829516
131MP0001664_abnormal_digestion0.60796844
132MP0008872_abnormal_physiological_respon0.59870620
133MP0001943_abnormal_respiration0.56940281
134MP0008961_abnormal_basal_metabolism0.56344774
135MP0008874_decreased_physiological_sensi0.56218615
136MP0000538_abnormal_urinary_bladder0.54387606

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.72810555
2Myokymia (HP:0002411)5.16423846
3Visual hallucinations (HP:0002367)5.04083513
4Focal seizures (HP:0007359)5.00688344
5Atonic seizures (HP:0010819)4.46232883
6Epileptic encephalopathy (HP:0200134)4.39251109
7Stomatitis (HP:0010280)4.13793678
8Hypochromic microcytic anemia (HP:0004840)4.08190741
9Absence seizures (HP:0002121)4.07008429
10Hyperventilation (HP:0002883)3.85163093
11Febrile seizures (HP:0002373)3.80231921
12Recurrent bacterial skin infections (HP:0005406)3.73163472
13Amblyopia (HP:0000646)3.72446592
14Recurrent abscess formation (HP:0002722)3.67432264
15Dialeptic seizures (HP:0011146)3.64164157
16Broad-based gait (HP:0002136)3.60361643
17Progressive cerebellar ataxia (HP:0002073)3.57817215
18Generalized tonic-clonic seizures (HP:0002069)3.44697494
19Aqueductal stenosis (HP:0002410)3.29180446
20Eczematoid dermatitis (HP:0000976)3.21411160
21Myositis (HP:0100614)3.17772205
22Epileptiform EEG discharges (HP:0011182)3.12417447
23Excessive salivation (HP:0003781)3.10880915
24Drooling (HP:0002307)3.10880915
25Neoplasm of the adrenal cortex (HP:0100641)3.08071840
26Retrobulbar optic neuritis (HP:0100654)3.03019261
27Optic neuritis (HP:0100653)3.03019261
28Limb dystonia (HP:0002451)3.02962666
29Orchitis (HP:0100796)3.02227049
30EEG with generalized epileptiform discharges (HP:0011198)3.00952364
31Episodic fever (HP:0001954)2.98236787
32Mutism (HP:0002300)2.93353830
33Anxiety (HP:0000739)2.92198105
34Supranuclear gaze palsy (HP:0000605)2.89637704
35Cerebral inclusion bodies (HP:0100314)2.89211893
36Hypsarrhythmia (HP:0002521)2.87112545
37Poor eye contact (HP:0000817)2.85713456
38Hypochromic anemia (HP:0001931)2.76481144
39Impaired vibration sensation in the lower limbs (HP:0002166)2.69085027
40Amyotrophic lateral sclerosis (HP:0007354)2.65405025
41Pheochromocytoma (HP:0002666)2.64103386
42Insidious onset (HP:0003587)2.63065740
43Termporal pattern (HP:0011008)2.63065740
44Polyphagia (HP:0002591)2.60368699
45Neurofibrillary tangles (HP:0002185)2.57726916
46Recurrent gram-negative bacterial infections (HP:0005420)2.57695689
47Progressive inability to walk (HP:0002505)2.56077261
48Abnormal eating behavior (HP:0100738)2.54881045
49Abnormal social behavior (HP:0012433)2.52236822
50Impaired social interactions (HP:0000735)2.52236822
51Truncal ataxia (HP:0002078)2.52160992
52Ankle clonus (HP:0011448)2.51741407
53Urinary bladder sphincter dysfunction (HP:0002839)2.51726761
54Depression (HP:0000716)2.50807269
55Abnormality of the corticospinal tract (HP:0002492)2.50716275
56Enlarged penis (HP:0000040)2.47580248
57Gait imbalance (HP:0002141)2.46820101
58Action tremor (HP:0002345)2.46588865
59Papilledema (HP:0001085)2.44420406
60Agitation (HP:0000713)2.37202749
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33389380
62Absent speech (HP:0001344)2.32206212
63Protruding tongue (HP:0010808)2.30908289
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30472510
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.28852710
66Hypoplasia of the brainstem (HP:0002365)2.28852710
67Recurrent skin infections (HP:0001581)2.28845077
68Urinary urgency (HP:0000012)2.26015176
69Stereotypic behavior (HP:0000733)2.23513314
70Hepatoblastoma (HP:0002884)2.23485278
71Dysdiadochokinesis (HP:0002075)2.23455565
72Neuroendocrine neoplasm (HP:0100634)2.23394700
73Hemiparesis (HP:0001269)2.23270373
74Intention tremor (HP:0002080)2.17857025
75Gaze-evoked nystagmus (HP:0000640)2.16176708
76Abnormality of macrophages (HP:0004311)2.14481079
77Inability to walk (HP:0002540)2.14383578
78Acute necrotizing encephalopathy (HP:0006965)2.13384878
79Abnormality of the labia minora (HP:0012880)2.13381968
80Dysmetria (HP:0001310)2.11417959
81Torticollis (HP:0000473)2.11179650
82Disinhibition (HP:0000734)2.11135206
83Restlessness (HP:0000711)2.10559817
84Abnormality of salivation (HP:0100755)2.09168062
85Progressive macrocephaly (HP:0004481)2.06941150
86Spastic gait (HP:0002064)2.06289697
87Abnormality of binocular vision (HP:0011514)2.05541407
88Diplopia (HP:0000651)2.05541407
89Obstructive lung disease (HP:0006536)2.01749086
90Chronic obstructive pulmonary disease (HP:0006510)2.01749086
91Congenital malformation of the right heart (HP:0011723)2.01026310
92Double outlet right ventricle (HP:0001719)2.01026310
93Hyperthyroidism (HP:0000836)2.00200108
94Failure to thrive in infancy (HP:0001531)1.99776277
95Focal dystonia (HP:0004373)1.99626236
96Hyperinsulinemic hypoglycemia (HP:0000825)1.97559738
97Fetal akinesia sequence (HP:0001989)1.97457554
98Keratoconjunctivitis (HP:0001096)1.96708299
99Genetic anticipation (HP:0003743)1.94959310
100Exotropia (HP:0000577)1.93995262
101Bradykinesia (HP:0002067)1.93297816
102Hypogonadotrophic hypogonadism (HP:0000044)1.93150331
103Recurrent fungal infections (HP:0002841)1.92713577
104Sporadic (HP:0003745)1.92414762
105Keratoconjunctivitis sicca (HP:0001097)1.92301226
106Impaired smooth pursuit (HP:0007772)1.91292475
107Akinesia (HP:0002304)1.90836080
108Encephalitis (HP:0002383)1.89678833
109Generalized myoclonic seizures (HP:0002123)1.88922018
110Stomach cancer (HP:0012126)1.88764029
111Megalencephaly (HP:0001355)1.88240786
112Lower limb muscle weakness (HP:0007340)1.87703428
113Impaired vibratory sensation (HP:0002495)1.86549007
114Abnormal mitochondria in muscle tissue (HP:0008316)1.86221300
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86155298
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.86155298
117Psychosis (HP:0000709)1.84648683
118Delusions (HP:0000746)1.84442751
119Lissencephaly (HP:0001339)1.84342429
120Medial flaring of the eyebrow (HP:0010747)1.83627177
121Abnormality of the lower motor neuron (HP:0002366)1.82509377
122Mediastinal lymphadenopathy (HP:0100721)1.81714015
123Specific learning disability (HP:0001328)1.80791466
124Craniofacial dystonia (HP:0012179)1.80479488
125Acute lymphatic leukemia (HP:0006721)1.80342560
126Lower limb asymmetry (HP:0100559)1.80294895
127Poor suck (HP:0002033)1.80119762
128Postural instability (HP:0002172)1.79794379
129Esotropia (HP:0000565)1.79627851
130Blue irides (HP:0000635)1.79124848
131Inappropriate behavior (HP:0000719)1.78852215
132Gingivitis (HP:0000230)1.78442810
133Sleep apnea (HP:0010535)1.77421675
134Retinal dysplasia (HP:0007973)1.76814058
135Congenital primary aphakia (HP:0007707)1.76075509
136Hypoventilation (HP:0002791)1.75737036
137Urticaria (HP:0001025)1.75734971
138Chronic mucocutaneous candidiasis (HP:0002728)1.75223986
139Recurrent cutaneous fungal infections (HP:0011370)1.75223986
140Decreased circulating renin level (HP:0003351)1.75108280
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.74474214
142Incomplete penetrance (HP:0003829)1.73685003
143Ventricular fibrillation (HP:0001663)1.71876428
144Buphthalmos (HP:0000557)1.71285434
145Growth hormone deficiency (HP:0000824)1.70189146
146Prolonged bleeding time (HP:0003010)1.69473118
147Tetany (HP:0001281)1.65040382
148Gastrointestinal infarctions (HP:0005244)1.63416360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.72618163
2NTRK34.16485916
3EPHA44.03888732
4MAP3K93.24206314
5CASK3.11308401
6MAP3K42.72756184
7MINK12.62553338
8FGFR22.54467242
9MAP2K72.50170644
10TNK22.42445220
11MAPK132.14073718
12MAP3K122.09500477
13DAPK22.06536037
14PNCK2.02395893
15NTRK21.96051433
16IRAK41.92656282
17YES11.91683663
18KSR11.79295459
19SIK21.77180895
20PLK21.75953388
21RIPK41.74076522
22GRK51.63521286
23MAP2K41.57211026
24DAPK11.56050968
25PAK61.55358472
26KSR21.54075257
27MAP2K31.50277911
28CDK51.44735141
29NTRK11.44120353
30UHMK11.42499658
31NME11.41881488
32GRK61.39709827
33PRKD31.38140029
34MAP3K21.33322285
35PRPF4B1.31573883
36PHKG11.30600093
37PHKG21.30600093
38ERBB31.27036464
39DYRK21.26622605
40INSRR1.25875525
41TNIK1.25619551
42PRKCG1.21447044
43CSK1.14215985
44CAMK1G1.13139218
45LATS21.12686316
46CAMK2A1.10610637
47BMPR21.09949917
48DYRK31.09127304
49BLK1.06565188
50TYK21.06512359
51ALK1.03122014
52HIPK21.02805780
53CAMKK11.02085236
54DYRK1A1.01437355
55IRAK21.01325106
56SIK30.99507584
57OXSR10.97551802
58CAMK1D0.97388900
59ACVR1B0.96413639
60EPHB10.95085631
61PAK30.94913242
62FRK0.94565089
63CAMK2B0.93783150
64PINK10.92830449
65ARAF0.91000561
66BCR0.85684979
67CSNK1G20.84866723
68MAP3K110.84096963
69FES0.82988436
70PTK60.82693739
71WNK30.81655593
72HCK0.81356654
73CDK140.79687333
74SGK2230.79407870
75SGK4940.79407870
76JAK20.79038903
77PASK0.78917489
78CDK180.78065842
79SGK20.77965123
80PRKCE0.73070558
81FGR0.72478803
82PTK2B0.71330826
83CDK150.71315321
84AKT30.70118505
85MARK20.68228253
86STK110.67917756
87GRK70.66180996
88SGK10.64282968
89PRKCZ0.62916258
90MKNK20.62591023
91CAMKK20.62285566
92MAP4K10.62218874
93LYN0.61878909
94CDK11A0.61480990
95IRAK10.59505512
96FGFR30.59452668
97STK380.59215111
98RET0.58621426
99MAP3K60.58476625
100TYRO30.55943202
101BMPR1B0.55481482
102NLK0.55207855
103CAMK2D0.55136778
104FER0.54295580
105ADRBK10.54144568
106CDK190.53764481
107SYK0.53712444
108MAP2K10.51592140
109CAMK10.51349181
110PRKCH0.50992188
111RPS6KA20.50487891
112PDK10.47198677
113WNK40.47022592
114WNK10.45148049
115MAP3K130.44633493
116TAOK10.44321615
117PKN10.43995780
118SGK30.42396326
119BTK0.41882711
120RPS6KA30.38546120
121CSNK1G30.38309071
122MAP3K10.37686419
123FYN0.37627607
124RPS6KB10.37606981
125PRKACA0.37309691
126DYRK1B0.36910340
127MAPK100.36035875
128MAP2K60.35748572
129TAF10.34886366
130CDC42BPA0.34449770
131PRKG10.33483562
132CAMK2G0.33268722
133STK240.33177935
134IKBKE0.32883579
135PRKCB0.32180779
136RPS6KA10.31413038
137BRAF0.31176358
138TEC0.30874827
139MUSK0.30756906
140TRIM280.29574439
141MARK30.29341148
142MATK0.29222038
143RAF10.29195961
144MAPK120.28410430
145CAMK40.27969538

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86057989
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94629699
3Long-term potentiation_Homo sapiens_hsa047202.77840120
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74067150
5Circadian entrainment_Homo sapiens_hsa047132.63795436
6Amphetamine addiction_Homo sapiens_hsa050312.56327303
7GABAergic synapse_Homo sapiens_hsa047272.55898688
8Olfactory transduction_Homo sapiens_hsa047402.51150845
9Glutamatergic synapse_Homo sapiens_hsa047242.49080275
10Morphine addiction_Homo sapiens_hsa050322.45956525
11Dopaminergic synapse_Homo sapiens_hsa047282.31065781
12Insulin secretion_Homo sapiens_hsa049112.15814441
13Taste transduction_Homo sapiens_hsa047422.15021180
14Serotonergic synapse_Homo sapiens_hsa047262.04842162
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90970780
16Cholinergic synapse_Homo sapiens_hsa047251.88327261
17Salivary secretion_Homo sapiens_hsa049701.83821893
18Renin secretion_Homo sapiens_hsa049241.83519649
19Cocaine addiction_Homo sapiens_hsa050301.83388629
20Collecting duct acid secretion_Homo sapiens_hsa049661.81847578
21Osteoclast differentiation_Homo sapiens_hsa043801.76278181
22Long-term depression_Homo sapiens_hsa047301.72831995
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65343709
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59517858
25Gastric acid secretion_Homo sapiens_hsa049711.58504439
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56672400
27Oxidative phosphorylation_Homo sapiens_hsa001901.56539568
28Oxytocin signaling pathway_Homo sapiens_hsa049211.54785351
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54478862
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51397123
31Calcium signaling pathway_Homo sapiens_hsa040201.50295332
32Alzheimers disease_Homo sapiens_hsa050101.47834606
33Axon guidance_Homo sapiens_hsa043601.42744435
34Cardiac muscle contraction_Homo sapiens_hsa042601.42395726
35Gap junction_Homo sapiens_hsa045401.41807738
36Chemokine signaling pathway_Homo sapiens_hsa040621.36177026
37Vibrio cholerae infection_Homo sapiens_hsa051101.35561724
38GnRH signaling pathway_Homo sapiens_hsa049121.31646731
39Parkinsons disease_Homo sapiens_hsa050121.29067269
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28076723
41Type II diabetes mellitus_Homo sapiens_hsa049301.28051081
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25935966
43Tuberculosis_Homo sapiens_hsa051521.21779295
44Estrogen signaling pathway_Homo sapiens_hsa049151.20978668
45Regulation of autophagy_Homo sapiens_hsa041401.19015528
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15171058
47Leishmaniasis_Homo sapiens_hsa051401.12855105
48B cell receptor signaling pathway_Homo sapiens_hsa046621.11366329
49cAMP signaling pathway_Homo sapiens_hsa040241.11224403
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11058618
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09796239
52Melanogenesis_Homo sapiens_hsa049161.08392881
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06008482
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05018204
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02714748
56Glioma_Homo sapiens_hsa052141.01010575
57Acute myeloid leukemia_Homo sapiens_hsa052211.00247900
58Inositol phosphate metabolism_Homo sapiens_hsa005620.99260161
59Vitamin B6 metabolism_Homo sapiens_hsa007500.98483571
60Huntingtons disease_Homo sapiens_hsa050160.95285570
61Phototransduction_Homo sapiens_hsa047440.93517982
62ErbB signaling pathway_Homo sapiens_hsa040120.91921457
63Prolactin signaling pathway_Homo sapiens_hsa049170.89234448
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.88315354
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86217763
66Non-small cell lung cancer_Homo sapiens_hsa052230.85656942
67Folate biosynthesis_Homo sapiens_hsa007900.85593641
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84096757
69Oocyte meiosis_Homo sapiens_hsa041140.82989424
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81469832
71Legionellosis_Homo sapiens_hsa051340.81288772
72FoxO signaling pathway_Homo sapiens_hsa040680.80163606
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74784931
74Pancreatic secretion_Homo sapiens_hsa049720.72552136
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71262681
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.71121780
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.70460637
78Dilated cardiomyopathy_Homo sapiens_hsa054140.69731958
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68957691
80T cell receptor signaling pathway_Homo sapiens_hsa046600.67503555
81Alcoholism_Homo sapiens_hsa050340.66854546
82Type I diabetes mellitus_Homo sapiens_hsa049400.66599928
83Thyroid hormone synthesis_Homo sapiens_hsa049180.66391680
84Glucagon signaling pathway_Homo sapiens_hsa049220.66141313
85MAPK signaling pathway_Homo sapiens_hsa040100.65712760
86Dorso-ventral axis formation_Homo sapiens_hsa043200.65606504
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59775789
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59466601
89Choline metabolism in cancer_Homo sapiens_hsa052310.57732406
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56705085
91Ras signaling pathway_Homo sapiens_hsa040140.56591323
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55688545
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55487394
94Wnt signaling pathway_Homo sapiens_hsa043100.54806949
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54685393
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54377959
97Prion diseases_Homo sapiens_hsa050200.53603902
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.52502572
99Endometrial cancer_Homo sapiens_hsa052130.51808857
100African trypanosomiasis_Homo sapiens_hsa051430.51569031
101AMPK signaling pathway_Homo sapiens_hsa041520.50767086
102VEGF signaling pathway_Homo sapiens_hsa043700.49507951
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.48852799
104Renal cell carcinoma_Homo sapiens_hsa052110.48704847
105Hepatitis C_Homo sapiens_hsa051600.48188975
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48029276
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47286536
108Platelet activation_Homo sapiens_hsa046110.47271413
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45728918
110Rap1 signaling pathway_Homo sapiens_hsa040150.45266435
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45220168
112Insulin signaling pathway_Homo sapiens_hsa049100.43440318
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40976950
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39358501
115mTOR signaling pathway_Homo sapiens_hsa041500.38044341
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.37299366
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36293126
118Colorectal cancer_Homo sapiens_hsa052100.35842010
119Circadian rhythm_Homo sapiens_hsa047100.35682514
120Butanoate metabolism_Homo sapiens_hsa006500.35020680
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34610302
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34157293
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34060110
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32768243
125Phagosome_Homo sapiens_hsa041450.32080636
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28741805
127Endocytosis_Homo sapiens_hsa041440.27812794
128Protein export_Homo sapiens_hsa030600.27619195
129Hedgehog signaling pathway_Homo sapiens_hsa043400.26411134

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