GPR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of hormone biosynthetic process (GO:0032353)4.64268871
2negative regulation of hormone metabolic process (GO:0032351)4.64268871
3piRNA metabolic process (GO:0034587)4.63419815
4mitotic metaphase plate congression (GO:0007080)4.59216630
5maturation of 5.8S rRNA (GO:0000460)4.58311476
6regulation of meiosis I (GO:0060631)4.32273033
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.20998502
8vitamin transmembrane transport (GO:0035461)4.01600720
9mitotic sister chromatid segregation (GO:0000070)3.87859219
10regulation of exit from mitosis (GO:0007096)3.87154960
11female gamete generation (GO:0007292)3.83782624
12* regulation of meiosis (GO:0040020)3.75051068
13nuclear pore organization (GO:0006999)3.71145580
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69427661
15establishment of integrated proviral latency (GO:0075713)3.68453426
16nuclear pore complex assembly (GO:0051292)3.67104525
17protein K6-linked ubiquitination (GO:0085020)3.66015640
18negative regulation of meiosis (GO:0045835)3.59246561
19synaptic vesicle exocytosis (GO:0016079)3.55066921
20replication fork processing (GO:0031297)3.51500741
21notochord development (GO:0030903)3.50986623
22regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.47501890
23regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.47501890
24establishment of viral latency (GO:0019043)3.45021932
25maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.43796030
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40670280
27metaphase plate congression (GO:0051310)3.37421675
28regulation of mitotic spindle organization (GO:0060236)3.37257686
29oocyte maturation (GO:0001556)3.35683291
30positive regulation of heat generation (GO:0031652)3.31512796
31monoubiquitinated protein deubiquitination (GO:0035520)3.30137479
32regulation of female gonad development (GO:2000194)3.29167683
33ribosome assembly (GO:0042255)3.28874747
34protein localization to chromosome, centromeric region (GO:0071459)3.28706606
35DNA replication checkpoint (GO:0000076)3.25283484
36glutamate secretion (GO:0014047)3.24085139
37* regulation of meiotic cell cycle (GO:0051445)3.23762058
38regulation of cell maturation (GO:1903429)3.22509742
39negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.22198700
40mitotic nuclear envelope disassembly (GO:0007077)3.21586508
41negative regulation of Ras GTPase activity (GO:0034261)3.20003900
42synaptic vesicle endocytosis (GO:0048488)3.14104836
43de novo protein folding (GO:0006458)3.13170108
44regulation of neurotransmitter uptake (GO:0051580)3.09979350
45regulation of sister chromatid cohesion (GO:0007063)3.09735126
46startle response (GO:0001964)3.09572484
47meiotic cell cycle (GO:0051321)3.07742511
48negative regulation of cell aging (GO:0090344)3.04181385
49positive regulation of megakaryocyte differentiation (GO:0045654)3.03508665
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01623841
51regulation of synaptic vesicle transport (GO:1902803)3.01500662
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01392309
53negative regulation of meiotic cell cycle (GO:0051447)3.01305921
54neuron cell-cell adhesion (GO:0007158)3.01280282
55DNA strand elongation involved in DNA replication (GO:0006271)3.00984836
56DNA double-strand break processing (GO:0000729)3.00505964
57regulation of spindle organization (GO:0090224)3.00404019
58snRNA transcription (GO:0009301)3.00203898
59membrane disassembly (GO:0030397)2.99943149
60nuclear envelope disassembly (GO:0051081)2.99943149
61DNA unwinding involved in DNA replication (GO:0006268)2.99849086
62de novo posttranslational protein folding (GO:0051084)2.99506692
63kinetochore assembly (GO:0051382)2.99102944
64male meiosis (GO:0007140)2.98685534
65DNA damage induced protein phosphorylation (GO:0006975)2.96829826
66DNA damage response, signal transduction resulting in transcription (GO:0042772)2.96566975
67glycerophospholipid catabolic process (GO:0046475)2.96492641
68neurotransmitter-gated ion channel clustering (GO:0072578)2.96375771
69DNA strand elongation (GO:0022616)2.94656508
70sister chromatid segregation (GO:0000819)2.94219905
71neuron-neuron synaptic transmission (GO:0007270)2.93811733
72chaperone-mediated protein transport (GO:0072321)2.93730896
73vocalization behavior (GO:0071625)2.93491129
74synaptic transmission, glutamatergic (GO:0035249)2.90716732
75proteasome assembly (GO:0043248)2.90270030
76histone H2A ubiquitination (GO:0033522)2.89982797
77kinetochore organization (GO:0051383)2.89033171
78regulation of cAMP-dependent protein kinase activity (GO:2000479)2.88411545
79protein maturation by protein folding (GO:0022417)2.87832615
80positive regulation of chromosome segregation (GO:0051984)2.86686824
81gamma-aminobutyric acid signaling pathway (GO:0007214)2.86296682
82polyamine biosynthetic process (GO:0006596)2.85503413
83positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.84922828
84pore complex assembly (GO:0046931)2.84692921
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83981419
86response to histamine (GO:0034776)2.83617336
87histone H2A monoubiquitination (GO:0035518)2.83364313
88protein localization to synapse (GO:0035418)2.82926950
89glutamate receptor signaling pathway (GO:0007215)2.82730768
90nuclear envelope reassembly (GO:0031468)2.81384543
91mitotic nuclear envelope reassembly (GO:0007084)2.81384543
92regulation of histone H3-K27 methylation (GO:0061085)2.81315862
93neuronal action potential propagation (GO:0019227)2.79559727
94pyrimidine dimer repair (GO:0006290)2.78143413
95oogenesis (GO:0048477)2.78097757
96behavioral defense response (GO:0002209)2.78023653
97behavioral fear response (GO:0001662)2.78023653
98neuromuscular process controlling posture (GO:0050884)2.77935691
99meiotic chromosome segregation (GO:0045132)2.77511609
100DNA strand renaturation (GO:0000733)2.77458654
101protein complex localization (GO:0031503)2.76745640
102positive regulation of mitochondrial fission (GO:0090141)2.76368815
103regulation of fever generation (GO:0031620)2.76036254
104establishment of chromosome localization (GO:0051303)2.75903001
105negative regulation of chromosome segregation (GO:0051985)2.74558120
106CENP-A containing nucleosome assembly (GO:0034080)2.73851978
107microtubule depolymerization (GO:0007019)2.73085841
108DNA methylation involved in gamete generation (GO:0043046)2.72823612
109mitotic chromosome condensation (GO:0007076)2.72732683
110peptidyl-arginine omega-N-methylation (GO:0035247)2.72450968
111protein retention in ER lumen (GO:0006621)2.72015665
112nuclear envelope organization (GO:0006998)2.71095117
113positive regulation of synapse maturation (GO:0090129)2.70386303
114protein localization to chromosome (GO:0034502)2.70331799
115negative regulation of circadian rhythm (GO:0042754)2.70225566
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.69995000
117peptidyl-threonine dephosphorylation (GO:0035970)2.69608897
118righting reflex (GO:0060013)2.69552895
119regulation of DNA methylation (GO:0044030)2.69159882
120histone arginine methylation (GO:0034969)2.69119897
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68895167
122SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.68863700
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.67181717
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.66472488
125negative regulation of sister chromatid segregation (GO:0033046)2.66472488
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.66472488
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.66472488
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66472488
129COPI coating of Golgi vesicle (GO:0048205)2.65899865
130Golgi transport vesicle coating (GO:0048200)2.65899865
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.65622215
132single strand break repair (GO:0000012)2.64781618
133regulation of synapse structural plasticity (GO:0051823)2.63525845
134regulation of synaptic vesicle exocytosis (GO:2000300)2.63300457
135heterochromatin organization (GO:0070828)2.63275140
136negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63072681
137folic acid-containing compound biosynthetic process (GO:0009396)2.62209192
138layer formation in cerebral cortex (GO:0021819)2.61962711
139negative regulation of smooth muscle cell differentiation (GO:0051151)2.61674894
140DNA damage response, detection of DNA damage (GO:0042769)2.61313146
141mitotic spindle organization (GO:0007052)2.60579736
142retinal cone cell development (GO:0046549)2.60343738
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60139795
144synaptic vesicle docking involved in exocytosis (GO:0016081)2.59718875
145microtubule severing (GO:0051013)2.59633908
146protein polyglutamylation (GO:0018095)2.58435573
147regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58204030
148chromatin remodeling at centromere (GO:0031055)2.57346483
149regulation of chromosome segregation (GO:0051983)2.55158319
150mitotic sister chromatid cohesion (GO:0007064)2.53846799
151chromosome segregation (GO:0007059)2.53639929
152transcription from mitochondrial promoter (GO:0006390)2.52369774
153meiosis I (GO:0007127)2.51830478
154lung-associated mesenchyme development (GO:0060484)2.51649750
155IMP biosynthetic process (GO:0006188)2.50667674
156regulation of double-strand break repair via homologous recombination (GO:0010569)2.49750036
157protein deneddylation (GO:0000338)2.49105937
158poly(A)+ mRNA export from nucleus (GO:0016973)2.48191718
159regulation of clathrin-mediated endocytosis (GO:2000369)2.48047776
160protein localization to kinetochore (GO:0034501)2.47929851
161negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47855092
162regulation of heat generation (GO:0031650)2.47806450
163protein insertion into membrane (GO:0051205)2.47357823
164regulation of translational fidelity (GO:0006450)2.46504998
165positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.45918723
166L-alpha-amino acid transmembrane transport (GO:1902475)2.45512430
167ventricular cardiac muscle cell development (GO:0055015)2.44660545
168regulation of ubiquitin-protein transferase activity (GO:0051438)2.43691586
169negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42429190
170mitotic spindle checkpoint (GO:0071174)2.41422720
171positive regulation of TOR signaling (GO:0032008)2.40677775
172protein refolding (GO:0042026)2.38427827
173regulation of helicase activity (GO:0051095)2.37904735
174spindle checkpoint (GO:0031577)2.37852334
175telomere maintenance via semi-conservative replication (GO:0032201)2.36198955
176negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.35936302
177mitotic spindle assembly checkpoint (GO:0007094)2.34693667
178regulation of mitotic spindle checkpoint (GO:1903504)2.34430452
179regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34430452
180cellular protein complex localization (GO:0034629)2.33282120
181regulation of sister chromatid segregation (GO:0033045)2.32372693
182regulation of mitotic sister chromatid separation (GO:0010965)2.32372693
183regulation of mitotic sister chromatid segregation (GO:0033047)2.32372693
184DNA replication-independent nucleosome organization (GO:0034724)2.30954084
185DNA replication-independent nucleosome assembly (GO:0006336)2.30954084
186protein K11-linked ubiquitination (GO:0070979)2.30656171
187proline biosynthetic process (GO:0006561)2.30414879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32640535
2EZH2_22144423_ChIP-Seq_EOC_Human5.03149559
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28398896
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.14519898
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.05886981
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.99966565
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95943348
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79874823
9GBX2_23144817_ChIP-Seq_PC3_Human2.76561081
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.76499312
11XRN2_22483619_ChIP-Seq_HELA_Human2.75938008
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.71940959
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.66780770
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66517597
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63622244
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50037878
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49782460
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39214637
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37779564
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36215730
21* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32313616
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27259650
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23097805
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.22800232
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.21442536
26DCP1A_22483619_ChIP-Seq_HELA_Human2.21052268
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.20848834
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.19108124
29GABP_19822575_ChIP-Seq_HepG2_Human2.03275702
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02828682
31TTF2_22483619_ChIP-Seq_HELA_Human1.98087260
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97625325
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97594952
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94020599
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93709766
36* REST_21632747_ChIP-Seq_MESCs_Mouse1.92116288
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91838291
38* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91559124
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89820067
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88526667
41AR_21572438_ChIP-Seq_LNCaP_Human1.88199501
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.87308326
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85161322
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82477073
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82453978
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81725810
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.81452209
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81421136
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79267148
50RNF2_27304074_Chip-Seq_NSC_Mouse1.75765436
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.74854377
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74819046
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72457415
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70432721
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69256186
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65819834
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65603866
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.64231992
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61872992
60ZNF263_19887448_ChIP-Seq_K562_Human1.61112414
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59713840
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59118619
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57290787
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57265512
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57265512
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53675643
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53139718
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52013275
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50720019
70FUS_26573619_Chip-Seq_HEK293_Human1.48902923
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.48774805
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48456893
73KDM5A_27292631_Chip-Seq_BREAST_Human1.47746623
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.47264899
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46093312
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44881451
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.44153369
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42889923
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41071550
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40265834
81* RARB_27405468_Chip-Seq_BRAIN_Mouse1.39831428
82SMAD4_21799915_ChIP-Seq_A2780_Human1.38659348
83STAT3_23295773_ChIP-Seq_U87_Human1.38567136
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38274899
85* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37321083
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36591091
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35579774
88FOXP3_21729870_ChIP-Seq_TREG_Human1.34808453
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33920729
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33773179
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33214978
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.32550311
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30079809
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.29812080
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29724010
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29724010
97TAF15_26573619_Chip-Seq_HEK293_Human1.28673659
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.26274601
99ELK1_19687146_ChIP-ChIP_HELA_Human1.23885745
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21791954
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21726362
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21450654
103VDR_23849224_ChIP-Seq_CD4+_Human1.21292464
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.21140593
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20466613
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.20416683
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20024598
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19321752
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19202906
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18071039
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.16662819
112AR_25329375_ChIP-Seq_VCAP_Human1.15700621
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15305055
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15074256
115* TBL1_22424771_ChIP-Seq_293T_Human1.14924048
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14204021
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13645775
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13500392
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13077894
120PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11817913
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10709216
122TET1_21490601_ChIP-Seq_MESCs_Mouse1.10269678
123AR_21909140_ChIP-Seq_LNCAP_Human1.09744797
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09733257
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09528296
126* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09358156
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.08533461
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08153836
129MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07593794
130TFEB_21752829_ChIP-Seq_HELA_Human1.06826191
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06502468
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.05750736
133EWS_26573619_Chip-Seq_HEK293_Human1.04789711
134CIITA_25753668_ChIP-Seq_RAJI_Human1.04197283
135* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03977270
136ERG_21242973_ChIP-ChIP_JURKAT_Human1.03522875
137POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03447209
138SRF_21415370_ChIP-Seq_HL-1_Mouse1.03431280
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.02875920
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02577968
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02252427
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01028941
143NANOG_21062744_ChIP-ChIP_HESCs_Human1.00793574
144SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00533650
145SOX2_21211035_ChIP-Seq_LN229_Gbm1.00331807
146PIAS1_25552417_ChIP-Seq_VCAP_Human1.00043371
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.99148749
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99072532
149RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98969535
150* ETV1_20927104_ChIP-Seq_GIST48_Human0.98406016
151STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98399197
152* NFYA_21822215_ChIP-Seq_K562_Human0.98113612
153TCF4_23295773_ChIP-Seq_U87_Human0.98044639
154FOXP1_21924763_ChIP-Seq_HESCs_Human0.97906966
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97794756
156TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97683070
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97314045
158HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97117920
159STAT3_18555785_Chip-Seq_ESCs_Mouse0.96978251
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96378998
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.95722682
162P300_19829295_ChIP-Seq_ESCs_Human0.95640751
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95225646
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94841713
165CLOCK_20551151_ChIP-Seq_293T_Human0.94758351
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94702928
167PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94547065
168MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93880316
169NFE2_27457419_Chip-Seq_LIVER_Mouse0.93625397
170CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93572360
171CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93134827
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93048172
173SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92836385
174KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92253261
175* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91623553
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91237291
177TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90946686
178* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90753047
179JUN_21703547_ChIP-Seq_K562_Human0.90583917
180BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90510886
181NCOR1_26117541_ChIP-Seq_K562_Human0.89973021
182SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89700828
183NMYC_18555785_Chip-Seq_ESCs_Mouse0.89022623
184E2F1_18555785_Chip-Seq_ESCs_Mouse0.88725055
185HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87688663
186KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87595583
187KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87595583
188ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86883860
189TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86717435
190MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86145086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.99945974
2MP0003646_muscle_fatigue3.90568197
3* MP0003718_maternal_effect3.33510305
4MP0008877_abnormal_DNA_methylation3.33058017
5MP0008058_abnormal_DNA_repair3.31332110
6MP0002653_abnormal_ependyma_morphology3.25511374
7MP0003880_abnormal_central_pattern3.19467839
8MP0003787_abnormal_imprinting2.96144552
9MP0003123_paternal_imprinting2.72292908
10MP0008007_abnormal_cellular_replicative2.71346304
11MP0005451_abnormal_body_composition2.71009720
12MP0003635_abnormal_synaptic_transmissio2.55940277
13MP0002102_abnormal_ear_morphology2.44952328
14MP0003693_abnormal_embryo_hatching2.43372009
15MP0009046_muscle_twitch2.24939307
16MP0002063_abnormal_learning/memory/cond2.21627800
17MP0004270_analgesia2.20578671
18MP0001529_abnormal_vocalization2.16043770
19MP0009745_abnormal_behavioral_response2.09837931
20MP0003136_yellow_coat_color2.03166420
21MP0003111_abnormal_nucleus_morphology1.98572922
22MP0005646_abnormal_pituitary_gland1.92219085
23MP0001730_embryonic_growth_arrest1.92175266
24MP0002572_abnormal_emotion/affect_behav1.89519192
25MP0010094_abnormal_chromosome_stability1.89084477
26MP0002064_seizures1.88619340
27MP0002734_abnormal_mechanical_nocicepti1.82009373
28MP0002736_abnormal_nociception_after1.79444440
29MP0009672_abnormal_birth_weight1.76997968
30MP0002163_abnormal_gland_morphology1.74683144
31MP0001968_abnormal_touch/_nociception1.71893957
32MP0010030_abnormal_orbit_morphology1.71373781
33MP0008057_abnormal_DNA_replication1.55209641
34* MP0003699_abnormal_female_reproductive1.54538321
35MP0004885_abnormal_endolymph1.52719650
36MP0004957_abnormal_blastocyst_morpholog1.52561148
37MP0001986_abnormal_taste_sensitivity1.47216418
38MP0001501_abnormal_sleep_pattern1.47102871
39MP0000579_abnormal_nail_morphology1.46249531
40MP0003121_genomic_imprinting1.45715342
41MP0005171_absent_coat_pigmentation1.45423082
42MP0009840_abnormal_foam_cell1.45329226
43MP0006292_abnormal_olfactory_placode1.44817818
44MP0001486_abnormal_startle_reflex1.44706102
45MP0008260_abnormal_autophagy1.43406319
46MP0003122_maternal_imprinting1.43224507
47MP0001905_abnormal_dopamine_level1.41990556
48MP0010352_gastrointestinal_tract_polyps1.40627723
49MP0003879_abnormal_hair_cell1.40206318
50MP0002735_abnormal_chemical_nociception1.39324334
51MP0002080_prenatal_lethality1.38528932
52MP0003077_abnormal_cell_cycle1.36984347
53MP0001440_abnormal_grooming_behavior1.35726826
54MP0002272_abnormal_nervous_system1.33343166
55MP0001119_abnormal_female_reproductive1.30936469
56MP0004233_abnormal_muscle_weight1.30604773
57MP0006276_abnormal_autonomic_nervous1.28408298
58* MP0001970_abnormal_pain_threshold1.27919369
59MP0005501_abnormal_skin_physiology1.27906753
60MP0005423_abnormal_somatic_nervous1.26976693
61MP0000653_abnormal_sex_gland1.25238400
62* MP0001929_abnormal_gametogenesis1.24798775
63MP0008995_early_reproductive_senescence1.23664128
64MP0000462_abnormal_digestive_system1.22345751
65MP0005379_endocrine/exocrine_gland_phen1.21799919
66MP0002067_abnormal_sensory_capabilities1.21505596
67MP0002184_abnormal_innervation1.20281395
68MP0001502_abnormal_circadian_rhythm1.19305615
69MP0000313_abnormal_cell_death1.18595168
70MP0002210_abnormal_sex_determination1.17998204
71MP0000750_abnormal_muscle_regeneration1.17575302
72MP0004147_increased_porphyrin_level1.17152370
73MP0000639_abnormal_adrenal_gland1.15914984
74MP0004142_abnormal_muscle_tone1.14892663
75MP0004924_abnormal_behavior1.12325165
76MP0005386_behavior/neurological_phenoty1.12325165
77MP0008932_abnormal_embryonic_tissue1.11426604
78MP0003984_embryonic_growth_retardation1.10995428
79MP0003567_abnormal_fetal_cardiomyocyte1.10740179
80MP0003890_abnormal_embryonic-extraembry1.10543909
81MP0003221_abnormal_cardiomyocyte_apopto1.09694328
82MP0002822_catalepsy1.09572483
83MP0003119_abnormal_digestive_system1.08863323
84* MP0005395_other_phenotype1.08824467
85* MP0002733_abnormal_thermal_nociception1.07583170
86MP0005623_abnormal_meninges_morphology1.06626218
87MP0002249_abnormal_larynx_morphology1.05432244
88MP0000358_abnormal_cell_content/1.05330387
89MP0004185_abnormal_adipocyte_glucose1.03695725
90MP0002088_abnormal_embryonic_growth/wei1.03611214
91MP0003755_abnormal_palate_morphology1.03055944
92MP0003329_amyloid_beta_deposits1.02784623
93* MP0002161_abnormal_fertility/fecundity1.00495656
94MP0003938_abnormal_ear_development0.99644934
95MP0000955_abnormal_spinal_cord0.95775836
96MP0003937_abnormal_limbs/digits/tail_de0.95160735
97MP0009703_decreased_birth_body0.91395142
98MP0000778_abnormal_nervous_system0.90476534
99MP0005384_cellular_phenotype0.89814989
100MP0002066_abnormal_motor_capabilities/c0.89280980
101MP0001145_abnormal_male_reproductive0.88763093
102MP0002938_white_spotting0.88521494
103MP0003786_premature_aging0.87934397
104MP0002638_abnormal_pupillary_reflex0.87679040
105MP0005257_abnormal_intraocular_pressure0.86959256
106MP0000647_abnormal_sebaceous_gland0.86787201
107MP0002697_abnormal_eye_size0.86447819
108MP0002751_abnormal_autonomic_nervous0.84834423
109MP0002557_abnormal_social/conspecific_i0.83691171
110MP0002882_abnormal_neuron_morphology0.83680006
111MP0001963_abnormal_hearing_physiology0.83468704
112MP0002877_abnormal_melanocyte_morpholog0.83409845
113MP0008770_decreased_survivor_rate0.83001853
114MP0000015_abnormal_ear_pigmentation0.82303085
115MP0005621_abnormal_cell_physiology0.82266955
116MP0001697_abnormal_embryo_size0.82118720
117MP0000566_synostosis0.80857227
118MP0003698_abnormal_male_reproductive0.80684626
119MP0003861_abnormal_nervous_system0.80619636
120MP0001661_extended_life_span0.80415497
121MP0003806_abnormal_nucleotide_metabolis0.80394054
122MP0001293_anophthalmia0.80232782
123MP0002086_abnormal_extraembryonic_tissu0.80116480
124MP0002089_abnormal_postnatal_growth/wei0.80006843
125MP0002085_abnormal_embryonic_tissue0.79311656
126MP0002152_abnormal_brain_morphology0.78481806
127MP0009697_abnormal_copulation0.77721670
128MP0005410_abnormal_fertilization0.77043310
129MP0001485_abnormal_pinna_reflex0.76688037
130MP0002282_abnormal_trachea_morphology0.76268171
131MP0000003_abnormal_adipose_tissue0.75573938
132MP0000350_abnormal_cell_proliferation0.74419265
133MP0003941_abnormal_skin_development0.73963164
134MP0005499_abnormal_olfactory_system0.72657106
135MP0005394_taste/olfaction_phenotype0.72657106
136MP0002332_abnormal_exercise_endurance0.72598240
137MP0001188_hyperpigmentation0.71202703
138MP0005167_abnormal_blood-brain_barrier0.70389379
139MP0005380_embryogenesis_phenotype0.70263388
140MP0001672_abnormal_embryogenesis/_devel0.70263388
141MP0005187_abnormal_penis_morphology0.69524176
142MP0004811_abnormal_neuron_physiology0.68748455
143MP0002092_abnormal_eye_morphology0.68464405
144MP0002081_perinatal_lethality0.68461679
145MP0004484_altered_response_of0.68022901
146MP0002084_abnormal_developmental_patter0.67638967
147MP0009250_abnormal_appendicular_skeleto0.67025400
148MP0005076_abnormal_cell_differentiation0.66933662
149MP0000516_abnormal_urinary_system0.63989491
150MP0005367_renal/urinary_system_phenotyp0.63989491
151MP0008789_abnormal_olfactory_epithelium0.63508504
152MP0008569_lethality_at_weaning0.63494945
153MP0002752_abnormal_somatic_nervous0.62483560
154MP0002909_abnormal_adrenal_gland0.61534598

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.15920303
2Irregular epiphyses (HP:0010582)4.82984359
3Cortical dysplasia (HP:0002539)4.80889971
4Male infertility (HP:0003251)4.75549769
5Flat capital femoral epiphysis (HP:0003370)4.57936794
6Abnormality of the labia minora (HP:0012880)4.31573271
7Atonic seizures (HP:0010819)4.14013347
8Upper limb muscle weakness (HP:0003484)3.95974676
9Abnormal gallbladder physiology (HP:0012438)3.88377186
10Cholecystitis (HP:0001082)3.88377186
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.49648535
12Febrile seizures (HP:0002373)3.45708575
13Facial hemangioma (HP:0000329)3.42531684
14Myokymia (HP:0002411)3.35712871
15Fetal akinesia sequence (HP:0001989)3.32916203
16Increased hepatocellular lipid droplets (HP:0006565)3.30935679
17Adrenal hypoplasia (HP:0000835)3.24199017
18Poikiloderma (HP:0001029)3.16577754
19Carpal bone hypoplasia (HP:0001498)3.16187061
20Breast hypoplasia (HP:0003187)3.12483732
21Hypokinesia (HP:0002375)3.10586365
22Abnormality of the epiphysis of the femoral head (HP:0010574)3.09922097
23Capillary hemangiomas (HP:0005306)3.08277040
24Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.07291506
25Abnormality of femoral epiphyses (HP:0006499)3.07291506
26Renal Fanconi syndrome (HP:0001994)3.05402369
27Hand muscle atrophy (HP:0009130)3.01120390
28Small epiphyses (HP:0010585)2.98995854
29Breast aplasia (HP:0100783)2.92540299
30Patellar aplasia (HP:0006443)2.91906077
31Shawl scrotum (HP:0000049)2.87487917
32Birth length less than 3rd percentile (HP:0003561)2.87438892
33Abnormality of the femoral head (HP:0003368)2.85663685
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81954221
35Epileptic encephalopathy (HP:0200134)2.74447626
36Aplasia/Hypoplasia of the patella (HP:0006498)2.72903830
37Aplasia/Hypoplasia of the breasts (HP:0010311)2.71424545
38Papillary thyroid carcinoma (HP:0002895)2.65811805
39Genetic anticipation (HP:0003743)2.65658802
40Lipid accumulation in hepatocytes (HP:0006561)2.63122792
41Progressive external ophthalmoplegia (HP:0000590)2.60140472
42Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.59677137
43Absent epiphyses (HP:0010577)2.59677137
44Nonimmune hydrops fetalis (HP:0001790)2.57827777
45Testicular atrophy (HP:0000029)2.57257350
46Focal seizures (HP:0007359)2.53161048
47Distal upper limb amyotrophy (HP:0007149)2.51899117
48Upper limb amyotrophy (HP:0009129)2.51899117
49Oligodactyly (hands) (HP:0001180)2.50568811
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.46021592
51Vitreoretinal degeneration (HP:0000655)2.44772796
52Epiphyseal dysplasia (HP:0002656)2.44279258
53Infertility (HP:0000789)2.41328687
54Progressive cerebellar ataxia (HP:0002073)2.39603157
55Squamous cell carcinoma (HP:0002860)2.39601857
56Cystic hygroma (HP:0000476)2.37837573
57Cholelithiasis (HP:0001081)2.34069756
58Sensory axonal neuropathy (HP:0003390)2.32886336
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.32393264
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30701639
61Premature ovarian failure (HP:0008209)2.29931433
62Microvesicular hepatic steatosis (HP:0001414)2.27059784
63Retinal dysplasia (HP:0007973)2.24299841
64Generalized hypotonia (HP:0001290)2.23951528
65Entropion (HP:0000621)2.21486891
66Abnormal lung lobation (HP:0002101)2.19606543
67Abnormal gallbladder morphology (HP:0012437)2.17234703
68Genu varum (HP:0002970)2.14272630
69Peripheral hypomyelination (HP:0007182)2.14004058
70Absent radius (HP:0003974)2.11568891
71Reticulocytosis (HP:0001923)2.10205155
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06506777
73Absence seizures (HP:0002121)2.04922195
74Concave nail (HP:0001598)2.04777253
75Abdominal situs inversus (HP:0003363)2.04537549
76Abnormality of abdominal situs (HP:0011620)2.04537549
77Delayed CNS myelination (HP:0002188)2.03891253
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03015718
79Hypoplasia of the brainstem (HP:0002365)2.03015718
80Diminished movement (HP:0002374)2.02990330
81Thickened helices (HP:0000391)2.02895110
82Mutism (HP:0002300)2.02727350
83Broad-based gait (HP:0002136)2.02102507
84Absent forearm bone (HP:0003953)2.01976708
85Aplasia involving forearm bones (HP:0009822)2.01976708
86Shoulder girdle muscle weakness (HP:0003547)2.01854840
87Rib fusion (HP:0000902)1.99605204
88Abnormality of the vertebral endplates (HP:0005106)1.99086383
89Oligodactyly (HP:0012165)1.98604926
90Truncus arteriosus (HP:0001660)1.98152018
91Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97927474
92Abnormal hair whorl (HP:0010721)1.96792599
93Dialeptic seizures (HP:0011146)1.96778002
94Delayed epiphyseal ossification (HP:0002663)1.96081701
95Increased nuchal translucency (HP:0010880)1.95999384
96Hypoplastic ischia (HP:0003175)1.95748728
97Athetosis (HP:0002305)1.95430778
98Exertional dyspnea (HP:0002875)1.95177651
99Increased intramyocellular lipid droplets (HP:0012240)1.94927777
100Secondary amenorrhea (HP:0000869)1.93200739
101Turricephaly (HP:0000262)1.90365443
102Chromsome breakage (HP:0040012)1.89440288
103Sparse lateral eyebrow (HP:0005338)1.89287876
104Abnormality of the gallbladder (HP:0005264)1.89018693
105Mild short stature (HP:0003502)1.88403015
106Pancreatic fibrosis (HP:0100732)1.88311469
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87661831
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86867104
109Annular pancreas (HP:0001734)1.86661564
110Aplasia of the musculature (HP:0100854)1.85046001
111Poor coordination (HP:0002370)1.84965704
112Gaze-evoked nystagmus (HP:0000640)1.83104202
113Progressive muscle weakness (HP:0003323)1.82535542
114Hypogonadotrophic hypogonadism (HP:0000044)1.81976327
115Attenuation of retinal blood vessels (HP:0007843)1.81041858
116Generalized myoclonic seizures (HP:0002123)1.80916112
117Impulsivity (HP:0100710)1.79446890
118Ankle clonus (HP:0011448)1.79322038
119Cortical visual impairment (HP:0100704)1.78942192
120Abnormal social behavior (HP:0012433)1.78290729
121Impaired social interactions (HP:0000735)1.78290729
122Delayed myelination (HP:0012448)1.78192526
123Ventricular fibrillation (HP:0001663)1.77536964
124Selective tooth agenesis (HP:0001592)1.77508982
125Gout (HP:0001997)1.77119204
126Complete atrioventricular canal defect (HP:0001674)1.75764476
127Self-mutilation (HP:0000742)1.75159071
128Failure to thrive in infancy (HP:0001531)1.74804864
129Gait imbalance (HP:0002141)1.74422890
130Supernumerary spleens (HP:0009799)1.73948478
131Abnormality of the ileum (HP:0001549)1.73762197
132Generalized tonic-clonic seizures (HP:0002069)1.73240512
133Cerebral hypomyelination (HP:0006808)1.73218537
134Esotropia (HP:0000565)1.71435824
135Abnormality of reticulocytes (HP:0004312)1.69415213
136Bundle branch block (HP:0011710)1.69313300
137Prominent metopic ridge (HP:0005487)1.69027651
138Polyphagia (HP:0002591)1.68804054
139Drooling (HP:0002307)1.67011697
140Excessive salivation (HP:0003781)1.67011697
141Obstructive sleep apnea (HP:0002870)1.66972989
142Tetraparesis (HP:0002273)1.66907888
143Termporal pattern (HP:0011008)1.66458479
144Insidious onset (HP:0003587)1.66458479
145Unsteady gait (HP:0002317)1.66213075
146Hypoplastic iliac wings (HP:0002866)1.65843343
147Spastic gait (HP:0002064)1.65681661
148Ulnar bowing (HP:0003031)1.65454712
149Dysmetric saccades (HP:0000641)1.65239982
150Primary amenorrhea (HP:0000786)1.65157400
151Abnormality of alanine metabolism (HP:0010916)1.64631407
152Hyperalaninemia (HP:0003348)1.64631407
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64631407
154Abnormality of chromosome segregation (HP:0002916)1.64225756
155Dyschromatopsia (HP:0007641)1.63852609
156Insulin-resistant diabetes mellitus (HP:0000831)1.63691222
157Inability to walk (HP:0002540)1.63668356
158Visual hallucinations (HP:0002367)1.62952557
159Congenital primary aphakia (HP:0007707)1.62472874
160Abnormality of male internal genitalia (HP:0000022)1.61712994
161Respiratory difficulties (HP:0002880)1.61233473
162Irregular vertebral endplates (HP:0003301)1.60747899
163Absent hand (HP:0004050)1.60671949
164Cutaneous melanoma (HP:0012056)1.60654832
165Heterotopia (HP:0002282)1.59603755
166Postnatal microcephaly (HP:0005484)1.59311152
167Amblyopia (HP:0000646)1.56814552
168Degeneration of anterior horn cells (HP:0002398)1.54594960
169Abnormality of the anterior horn cell (HP:0006802)1.54594960
170Exercise intolerance (HP:0003546)1.54167640
171Impaired vibration sensation in the lower limbs (HP:0002166)1.53767525
172Hypoplastic pelvis (HP:0008839)1.53457262
173Bony spicule pigmentary retinopathy (HP:0007737)1.51950671
174Abnormality of the metopic suture (HP:0005556)1.48877473
175Small intestinal stenosis (HP:0012848)1.47880069
176Duodenal stenosis (HP:0100867)1.47880069
177External ophthalmoplegia (HP:0000544)1.47741097
178Small hand (HP:0200055)1.47333006
179Poor eye contact (HP:0000817)1.46955778
180Anteriorly placed anus (HP:0001545)1.46317921
181Vaginal fistula (HP:0004320)1.46231874
182Intestinal polyposis (HP:0200008)1.46219757
183Absent septum pellucidum (HP:0001331)1.45208128
184Rectal fistula (HP:0100590)1.44780061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.78409142
2LATS24.33517298
3MAP3K63.76901183
4LATS13.71432317
5STK38L3.38125412
6MAP3K93.32961009
7MAPK152.96481219
8TRIM282.73822670
9EIF2AK12.70227728
10ERBB42.68567434
11DYRK32.68036058
12AKT32.64777153
13KSR22.52661132
14TAOK12.37258232
15BCR2.24117690
16CSNK1A1L2.14262569
17MUSK2.10713212
18MAP3K42.07704530
19BRAF2.06675316
20PLK42.04063592
21RAF11.95364854
22SRPK11.90584779
23ARAF1.90182337
24PAK61.88061376
25PINK11.86651035
26SIK31.81945867
27CDK81.80921336
28MAP2K71.80441947
29NME21.78415729
30EPHA41.71988255
31NTRK31.70735583
32EIF2AK31.69370746
33TTK1.64339456
34CASK1.59444117
35KSR11.50433409
36STK381.49849615
37BUB11.49289832
38IRAK31.48755689
39PBK1.46211756
40CHEK21.43290305
41STK31.38282069
42PLK21.37981099
43DDR21.31000535
44MAP3K121.24495860
45MKNK21.22347134
46CLK11.20091739
47MAP3K131.19620558
48PRKD31.17771478
49CSNK1G21.11735732
50CDK141.11704727
51TIE11.10694531
52MAPK131.09873205
53MARK21.06678460
54TYRO31.06282926
55PAK41.05234649
56NTRK21.04952917
57UHMK11.03565425
58MST41.01840257
59EPHA21.01480058
60NTRK10.99562068
61TESK20.99296487
62NEK20.98675956
63DAPK10.98637663
64MAP2K40.97551118
65PRKD20.96689938
66PLK10.96572280
67MOS0.93961571
68MELK0.93207918
69RIPK10.91686985
70CDK120.90538662
71BRSK10.89414744
72STK160.89407042
73FGR0.87978915
74MKNK10.86158533
75STK100.85375242
76PLK30.84895101
77DYRK20.83803122
78MAP3K80.82062345
79PNCK0.81766792
80VRK20.80031254
81CAMK2A0.77700397
82VRK10.77506954
83NME10.76131417
84ICK0.74360907
85PAK10.74199753
86BRSK20.72276408
87STK240.71703735
88TNIK0.71488409
89CDK30.68668636
90PRKAA10.68362982
91ATR0.67479845
92TAOK30.66390756
93PTK20.66015768
94CDC70.65627793
95CCNB10.65602886
96PIM20.60213859
97CDK10.58971830
98CDK190.57536740
99BMX0.57438900
100BMPR20.57174680
101CSNK1G10.56546477
102EPHB10.55881482
103MAP3K110.54578294
104TAOK20.53829985
105SGK20.53734141
106PRKAA20.53710191
107CSNK1G30.53408252
108PDK30.52879896
109PDK40.52879896
110MINK10.52029755
111ABL20.51792526
112ATM0.51207647
113AURKA0.50135625
114EIF2AK20.49808475
115AKT20.48430920
116EEF2K0.48400180
117PAK20.48305369
118TESK10.48264822
119DMPK0.47847921
120BRD40.47666887
121OXSR10.47655622
122PRKCI0.47103410
123CDK20.46908814
124GRK70.46473523
125CDK180.46059148
126GRK50.45766435
127CDK150.44655899
128PDK20.43530451
129WEE10.43117140
130STK110.42823369
131CDK50.42710621
132FLT30.41609454
133MAP3K50.41456316
134CAMK2B0.41109439
135SIK20.40304009
136CHEK10.39926770
137PRKCG0.39527897
138EPHB20.39069539
139CDK90.38882733
140WNK40.38218303
141MARK10.37728458
142CDK11A0.37242185
143MAPK100.35196554
144MAPKAPK30.35117211
145DYRK1A0.34883622
146NEK10.34637747
147SGK4940.34425187
148SGK2230.34425187
149NEK60.34096340
150CDK70.31538239
151MET0.31309541
152SGK10.30990238
153AURKB0.29973672

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.85552077
2Nicotine addiction_Homo sapiens_hsa050333.40440463
3Circadian rhythm_Homo sapiens_hsa047102.93413121
4Synaptic vesicle cycle_Homo sapiens_hsa047212.73821814
5DNA replication_Homo sapiens_hsa030302.62078623
6Mismatch repair_Homo sapiens_hsa034302.40390981
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31137205
8Cell cycle_Homo sapiens_hsa041102.21277805
9Proteasome_Homo sapiens_hsa030502.14264393
10Oocyte meiosis_Homo sapiens_hsa041142.05363268
11Spliceosome_Homo sapiens_hsa030402.02153879
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99090859
13Basal transcription factors_Homo sapiens_hsa030221.98339511
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97424324
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97051480
16Collecting duct acid secretion_Homo sapiens_hsa049661.87050614
17RNA polymerase_Homo sapiens_hsa030201.86845161
18Ovarian steroidogenesis_Homo sapiens_hsa049131.83937785
19Long-term potentiation_Homo sapiens_hsa047201.81637656
20Amphetamine addiction_Homo sapiens_hsa050311.78145351
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76958231
22Glutamatergic synapse_Homo sapiens_hsa047241.75332944
23GABAergic synapse_Homo sapiens_hsa047271.73835138
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67232881
25Long-term depression_Homo sapiens_hsa047301.66105331
26Pyrimidine metabolism_Homo sapiens_hsa002401.62904877
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61254820
28Morphine addiction_Homo sapiens_hsa050321.58918066
29Circadian entrainment_Homo sapiens_hsa047131.58269697
30GnRH signaling pathway_Homo sapiens_hsa049121.56720504
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56207905
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53867565
33Olfactory transduction_Homo sapiens_hsa047401.53118293
34Nucleotide excision repair_Homo sapiens_hsa034201.48520308
35Dorso-ventral axis formation_Homo sapiens_hsa043201.40040865
36Steroid biosynthesis_Homo sapiens_hsa001001.39669226
37Serotonergic synapse_Homo sapiens_hsa047261.39281813
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34326443
39Protein export_Homo sapiens_hsa030601.33540620
40RNA transport_Homo sapiens_hsa030131.33465950
41Dopaminergic synapse_Homo sapiens_hsa047281.31297127
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30499806
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27092960
44Choline metabolism in cancer_Homo sapiens_hsa052311.26329423
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25486784
46RNA degradation_Homo sapiens_hsa030181.25263430
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.23490939
48Fanconi anemia pathway_Homo sapiens_hsa034601.22556550
49Taste transduction_Homo sapiens_hsa047421.20001501
50Sphingolipid metabolism_Homo sapiens_hsa006001.19421630
51Salivary secretion_Homo sapiens_hsa049701.16729483
52Fatty acid biosynthesis_Homo sapiens_hsa000611.16243699
53Cocaine addiction_Homo sapiens_hsa050301.14019400
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12049075
55p53 signaling pathway_Homo sapiens_hsa041151.07133348
56mTOR signaling pathway_Homo sapiens_hsa041501.05922761
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04495011
58Parkinsons disease_Homo sapiens_hsa050121.04192177
59Oxytocin signaling pathway_Homo sapiens_hsa049211.03705478
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02746400
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02728130
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02401666
63TGF-beta signaling pathway_Homo sapiens_hsa043501.01629446
64Non-homologous end-joining_Homo sapiens_hsa034501.01464784
65Cholinergic synapse_Homo sapiens_hsa047250.99702655
66N-Glycan biosynthesis_Homo sapiens_hsa005100.99524495
67ErbB signaling pathway_Homo sapiens_hsa040120.98514867
68Selenocompound metabolism_Homo sapiens_hsa004500.98291077
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95127674
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95011833
71Huntingtons disease_Homo sapiens_hsa050160.94764886
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94744376
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93568689
74Sulfur relay system_Homo sapiens_hsa041220.93139191
75cAMP signaling pathway_Homo sapiens_hsa040240.92933425
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90981212
77Gap junction_Homo sapiens_hsa045400.90180413
78Fatty acid elongation_Homo sapiens_hsa000620.89653634
79Estrogen signaling pathway_Homo sapiens_hsa049150.88711926
80Insulin secretion_Homo sapiens_hsa049110.88104529
81Oxidative phosphorylation_Homo sapiens_hsa001900.86955582
82mRNA surveillance pathway_Homo sapiens_hsa030150.86340246
83Homologous recombination_Homo sapiens_hsa034400.86264595
84One carbon pool by folate_Homo sapiens_hsa006700.86089748
85Hippo signaling pathway_Homo sapiens_hsa043900.85748064
86Pancreatic cancer_Homo sapiens_hsa052120.82974654
87Shigellosis_Homo sapiens_hsa051310.81525803
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80923941
89Colorectal cancer_Homo sapiens_hsa052100.80077114
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78907377
91Calcium signaling pathway_Homo sapiens_hsa040200.78083051
92Phototransduction_Homo sapiens_hsa047440.77562864
93Renal cell carcinoma_Homo sapiens_hsa052110.76919262
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76502887
95Prion diseases_Homo sapiens_hsa050200.76280494
96Carbon metabolism_Homo sapiens_hsa012000.75341742
97MAPK signaling pathway_Homo sapiens_hsa040100.75010911
98Regulation of autophagy_Homo sapiens_hsa041400.73629707
99Inositol phosphate metabolism_Homo sapiens_hsa005620.73523976
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73273018
101VEGF signaling pathway_Homo sapiens_hsa043700.72434933
102Ras signaling pathway_Homo sapiens_hsa040140.72213099
103Fructose and mannose metabolism_Homo sapiens_hsa000510.68409841
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68295393
105Adherens junction_Homo sapiens_hsa045200.67068194
106Hedgehog signaling pathway_Homo sapiens_hsa043400.66870447
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.66064311
108Vibrio cholerae infection_Homo sapiens_hsa051100.65789760
109Ether lipid metabolism_Homo sapiens_hsa005650.65073831
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64542039
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63522796
112Purine metabolism_Homo sapiens_hsa002300.63199342
113FoxO signaling pathway_Homo sapiens_hsa040680.63031584
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62661594
115Folate biosynthesis_Homo sapiens_hsa007900.61989018
116Wnt signaling pathway_Homo sapiens_hsa043100.61574782
117Linoleic acid metabolism_Homo sapiens_hsa005910.61294629
118Glioma_Homo sapiens_hsa052140.58849037
119Epstein-Barr virus infection_Homo sapiens_hsa051690.58672192
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58563766
121Base excision repair_Homo sapiens_hsa034100.58448137
122Gastric acid secretion_Homo sapiens_hsa049710.54596992
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.54237139
124Bladder cancer_Homo sapiens_hsa052190.53969410
125Sulfur metabolism_Homo sapiens_hsa009200.53759828
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53715164
127Prolactin signaling pathway_Homo sapiens_hsa049170.52086996
128Melanoma_Homo sapiens_hsa052180.51403907
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.51129824
130Glutathione metabolism_Homo sapiens_hsa004800.51105036
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.50942804
132Pentose phosphate pathway_Homo sapiens_hsa000300.50544628
133Pyruvate metabolism_Homo sapiens_hsa006200.50193900
134Thyroid cancer_Homo sapiens_hsa052160.49873540
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49097838
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47469455
137MicroRNAs in cancer_Homo sapiens_hsa052060.47127113
138Melanogenesis_Homo sapiens_hsa049160.46834671
139Endometrial cancer_Homo sapiens_hsa052130.45355710
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44561713
141Axon guidance_Homo sapiens_hsa043600.43335458
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42996541
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41060747
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40679244
145Vitamin digestion and absorption_Homo sapiens_hsa049770.39690701
146Type II diabetes mellitus_Homo sapiens_hsa049300.38889065
147Biosynthesis of amino acids_Homo sapiens_hsa012300.37115445
148Alzheimers disease_Homo sapiens_hsa050100.36906541
149Rheumatoid arthritis_Homo sapiens_hsa053230.36546279
150Apoptosis_Homo sapiens_hsa042100.36072260
151Rap1 signaling pathway_Homo sapiens_hsa040150.35993738
152Viral carcinogenesis_Homo sapiens_hsa052030.35719063
153Salmonella infection_Homo sapiens_hsa051320.34804097
154Legionellosis_Homo sapiens_hsa051340.33564491
155Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33360452
156Arginine and proline metabolism_Homo sapiens_hsa003300.32627223
157Tight junction_Homo sapiens_hsa045300.30687192

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