GPR32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone metabolic process (GO:0042403)8.64342615
2blood vessel maturation (GO:0001955)7.83370251
3endothelial cell proliferation (GO:0001935)7.71862440
4thyroid gland development (GO:0030878)6.98814877
5estrogen biosynthetic process (GO:0006703)6.81186109
6negative regulation of blood vessel endothelial cell migration (GO:0043537)6.66988442
7negative regulation of organ growth (GO:0046621)6.12417952
8positive regulation of hair follicle development (GO:0051798)6.06839409
9positive regulation of hair cycle (GO:0042635)6.06839409
10sprouting angiogenesis (GO:0002040)6.05684907
11positive regulation of meiotic cell cycle (GO:0051446)5.79568368
12negative regulation of smooth muscle cell differentiation (GO:0051151)5.67724283
13tooth mineralization (GO:0034505)5.06302196
14response to insecticide (GO:0017085)4.97925543
15epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.76598082
16wound healing, spreading of epidermal cells (GO:0035313)4.57491319
17C21-steroid hormone biosynthetic process (GO:0006700)4.54897129
18negative regulation of endothelial cell migration (GO:0010596)4.44568534
19negative regulation of activin receptor signaling pathway (GO:0032926)4.31757362
20regulation of mitotic spindle organization (GO:0060236)4.29948622
21branching involved in labyrinthine layer morphogenesis (GO:0060670)4.27393007
22vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.18925412
23cranial suture morphogenesis (GO:0060363)4.16216922
24positive regulation of blood vessel endothelial cell migration (GO:0043536)4.15475991
25vitamin transmembrane transport (GO:0035461)4.04670635
26trabecula formation (GO:0060343)4.04063738
27regulation of hair follicle development (GO:0051797)3.96002465
28trophectodermal cell differentiation (GO:0001829)3.93287164
29post-embryonic morphogenesis (GO:0009886)3.85746645
30negative regulation of epidermal cell differentiation (GO:0045605)3.84678681
31pseudouridine synthesis (GO:0001522)3.79695090
32positive regulation of interleukin-1 beta secretion (GO:0050718)3.76363527
33keratinocyte development (GO:0003334)3.75992404
34regulation of interleukin-1 beta secretion (GO:0050706)3.65348477
35cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.64149123
36negative regulation of transcription regulatory region DNA binding (GO:2000678)3.54647703
37Leydig cell differentiation (GO:0033327)3.52871706
38positive regulation of interleukin-1 secretion (GO:0050716)3.52785300
39peptide hormone processing (GO:0016486)3.52279617
40cellular response to antibiotic (GO:0071236)3.49703824
41chemosensory behavior (GO:0007635)3.41927680
42estrogen metabolic process (GO:0008210)3.35641162
43regulation of spindle organization (GO:0090224)3.32733559
44cardiac epithelial to mesenchymal transition (GO:0060317)3.31650616
45progesterone metabolic process (GO:0042448)3.28095388
46L-alpha-amino acid transmembrane transport (GO:1902475)3.25017191
47positive regulation of meiosis (GO:0045836)3.23599793
48ribosomal small subunit assembly (GO:0000028)3.23552347
49wound healing, spreading of cells (GO:0044319)3.22575739
50negative regulation of epithelial cell migration (GO:0010633)3.15118674
51regulation of interleukin-1 secretion (GO:0050704)3.13925092
52basic amino acid transport (GO:0015802)3.12799729
53regulation of mesenchymal cell apoptotic process (GO:2001053)3.11270039
54heme transport (GO:0015886)3.10692721
55serine family amino acid catabolic process (GO:0009071)3.09169600
56negative regulation of epidermis development (GO:0045683)3.08745193
57regulation of hair cycle (GO:0042634)3.08533327
58response to follicle-stimulating hormone (GO:0032354)3.08292280
59androgen biosynthetic process (GO:0006702)3.08216489
60osteoblast development (GO:0002076)3.04898957
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.02709542
62female genitalia development (GO:0030540)3.02620509
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.02538986
64regulation of histone phosphorylation (GO:0033127)3.00395590
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99840999
66positive regulation of glycoprotein biosynthetic process (GO:0010560)2.98227459
67vagina development (GO:0060068)2.95822352
68benzene-containing compound metabolic process (GO:0042537)2.93772247
69cellular response to toxic substance (GO:0097237)2.89050316
70mitotic metaphase plate congression (GO:0007080)2.88671770
71maturation of SSU-rRNA (GO:0030490)2.88389705
72regulation of G0 to G1 transition (GO:0070316)2.80143568
73placenta development (GO:0001890)2.74301188
74glucocorticoid biosynthetic process (GO:0006704)2.74251285
75syncytium formation (GO:0006949)2.74180091
76outflow tract septum morphogenesis (GO:0003148)2.72568462
77DNA replication initiation (GO:0006270)2.72286308
78branching involved in ureteric bud morphogenesis (GO:0001658)2.70957308
79multicellular organism reproduction (GO:0032504)2.70781955
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.70335859
81anatomical structure maturation (GO:0071695)2.67496132
82natural killer cell differentiation (GO:0001779)2.67221379
83positive regulation of respiratory burst (GO:0060267)2.66213610
84negative regulation of astrocyte differentiation (GO:0048712)2.65085032
85negative regulation of T cell receptor signaling pathway (GO:0050860)2.62878405
86DNA demethylation (GO:0080111)2.60507584
87L-ascorbic acid metabolic process (GO:0019852)2.59138301
88ER overload response (GO:0006983)2.57584355
89response to nitrosative stress (GO:0051409)2.57437349
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57246120
91male sex determination (GO:0030238)2.57245308
92regulation of morphogenesis of a branching structure (GO:0060688)2.52541690
93DNA dealkylation (GO:0035510)2.52436962
94histone H3-K9 methylation (GO:0051567)2.51927027
95viral transcription (GO:0019083)2.50722830
96vitamin D metabolic process (GO:0042359)2.50437035
97endocrine hormone secretion (GO:0060986)13.1774111
98activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)12.3985125
99bone trabecula formation (GO:0060346)12.1234861
100thyroid hormone generation (GO:0006590)10.6324051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.26886877
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.73785264
3SCL_19346495_ChIP-Seq_HPC-7_Human4.03095291
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.81237978
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.80461386
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47417530
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38245175
8RNF2_27304074_Chip-Seq_NSC_Mouse2.29614547
9CBP_20019798_ChIP-Seq_JUKART_Human2.18835724
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.18835724
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12158400
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10347192
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10347192
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10347192
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09742422
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.06635763
17ZNF274_21170338_ChIP-Seq_K562_Hela2.03644911
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.81956329
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70686319
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70000002
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65677865
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57299651
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.56827348
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53534983
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52168239
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51387720
27AHR_22903824_ChIP-Seq_MCF-7_Human1.46256281
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40630125
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.39113481
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38426554
31IRF1_19129219_ChIP-ChIP_H3396_Human1.36202466
32GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.32988777
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.30071800
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27321137
35FUS_26573619_Chip-Seq_HEK293_Human1.27103826
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23849983
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23706128
38MYC_19829295_ChIP-Seq_ESCs_Human1.21625418
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17015448
40PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16494024
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.16108618
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15805895
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15328125
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.15328125
45JUN_21703547_ChIP-Seq_K562_Human1.14938832
46BCAT_22108803_ChIP-Seq_LS180_Human1.13684779
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13118651
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12027380
49P300_27268052_Chip-Seq_Bcells_Human1.11539503
50P300_19829295_ChIP-Seq_ESCs_Human1.11398023
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11231134
52EZH2_22144423_ChIP-Seq_EOC_Human1.10271375
53BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10018474
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08191199
55LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07073553
56ER_23166858_ChIP-Seq_MCF-7_Human1.06692818
57NANOG_20526341_ChIP-Seq_ESCs_Human1.05141927
58AR_20517297_ChIP-Seq_VCAP_Human1.05071202
59CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04752251
60NCOR_22424771_ChIP-Seq_293T_Human1.04673954
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04243711
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03466124
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02873409
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02437694
65GATA3_24758297_ChIP-Seq_MCF-7_Human1.01889321
66TP53_22573176_ChIP-Seq_HFKS_Human1.00404602
67RAC3_21632823_ChIP-Seq_H3396_Human0.99524203
68ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99226115
69* YY1_22570637_ChIP-Seq_MALME-3M_Human0.99050344
70GBX2_23144817_ChIP-Seq_PC3_Human0.97088136
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95830989
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93958956
73PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93295347
74KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93147987
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.92270195
76SMRT_27268052_Chip-Seq_Bcells_Human0.91285517
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88363269
78* CDX2_22108803_ChIP-Seq_LS180_Human0.88247499
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87921083
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87843892
81TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87060427
82EZH2_27304074_Chip-Seq_ESCs_Mouse0.86713679
83CSB_26484114_Chip-Seq_FIBROBLAST_Human0.85820196
84SMAD4_21741376_ChIP-Seq_EPCs_Human0.85304993
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84754090
86EST1_17652178_ChIP-ChIP_JURKAT_Human0.83199524
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.81934274
88PHF8_20622853_ChIP-Seq_HELA_Human0.81778432
89P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81468292
90GABP_17652178_ChIP-ChIP_JURKAT_Human0.80827082
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79899269
92ERA_21632823_ChIP-Seq_H3396_Human0.79411245
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79403249
94OCT4_19829295_ChIP-Seq_ESCs_Human0.79173570
95ERG_20517297_ChIP-Seq_VCAP_Human0.78984858
96STAT3_18555785_ChIP-Seq_MESCs_Mouse0.78979775
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.78342103
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.78018920
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78004979
100TP63_22573176_ChIP-Seq_HFKS_Human0.77367595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology8.32960062
2MP0000003_abnormal_adipose_tissue5.68926936
3MP0000569_abnormal_digit_pigmentation4.66486644
4MP0000647_abnormal_sebaceous_gland3.49407406
5MP0000681_abnormal_thyroid_gland3.26347281
6MP0002160_abnormal_reproductive_system3.03471886
7MP0000631_abnormal_neuroendocrine_gland3.02964240
8MP0002909_abnormal_adrenal_gland2.79212603
9MP0005375_adipose_tissue_phenotype2.54634408
10MP0002653_abnormal_ependyma_morphology2.42892886
11MP0010307_abnormal_tumor_latency2.40500150
12MP0000427_abnormal_hair_cycle2.17779408
13MP0001881_abnormal_mammary_gland2.10482255
14MP0002098_abnormal_vibrissa_morphology2.03522930
15MP0009672_abnormal_birth_weight1.96211112
16MP0005389_reproductive_system_phenotype1.88270390
17MP0009115_abnormal_fat_cell1.86130055
18MP0005023_abnormal_wound_healing1.81704079
19MP0005174_abnormal_tail_pigmentation1.77733735
20MP0000013_abnormal_adipose_tissue1.77720231
21MP0000377_abnormal_hair_follicle1.74477805
22MP0002837_dystrophic_cardiac_calcinosis1.67300168
23MP0003718_maternal_effect1.67104733
24MP0009333_abnormal_splenocyte_physiolog1.64172839
25MP0005076_abnormal_cell_differentiation1.56826805
26MP0000383_abnormal_hair_follicle1.56365913
27MP0008775_abnormal_heart_ventricle1.53934047
28MP0005410_abnormal_fertilization1.50537128
29MP0003567_abnormal_fetal_cardiomyocyte1.42165376
30MP0002127_abnormal_cardiovascular_syste1.39675336
31MP0003011_delayed_dark_adaptation1.35070371
32MP0003936_abnormal_reproductive_system1.32312252
33MP0002210_abnormal_sex_determination1.32036101
34MP0009697_abnormal_copulation1.27180607
35MP0000627_abnormal_mammary_gland1.26275038
36MP0008995_early_reproductive_senescence1.22859746
37MP0003448_altered_tumor_morphology1.18621598
38MP0001501_abnormal_sleep_pattern1.18508565
39MP0000516_abnormal_urinary_system1.16504976
40MP0005367_renal/urinary_system_phenotyp1.16504976
41MP0005595_abnormal_vascular_smooth1.15521371
42MP0002148_abnormal_hypersensitivity_rea1.14111231
43MP0005334_abnormal_fat_pad1.13417277
44MP0008875_abnormal_xenobiotic_pharmacok1.11564242
45MP0000015_abnormal_ear_pigmentation1.08922639
46MP0003698_abnormal_male_reproductive1.07268126
47MP0002796_impaired_skin_barrier1.06796153
48MP0004782_abnormal_surfactant_physiolog1.04847883
49MP0006082_CNS_inflammation1.04235634
50MP0009703_decreased_birth_body1.04021674
51MP0001119_abnormal_female_reproductive1.03343537
52MP0001929_abnormal_gametogenesis1.01208082
53MP0002638_abnormal_pupillary_reflex1.00003175
54MP0000639_abnormal_adrenal_gland0.99378063
55MP0000653_abnormal_sex_gland0.99363546
56MP0004264_abnormal_extraembryonic_tissu0.97810015
57MP0001145_abnormal_male_reproductive0.96918323
58MP0005646_abnormal_pituitary_gland0.95480702
59MP0005501_abnormal_skin_physiology0.91887234
60MP0003724_increased_susceptibility_to0.91709317
61MP0005551_abnormal_eye_electrophysiolog0.91139371
62MP0010678_abnormal_skin_adnexa0.90880274
63MP0003878_abnormal_ear_physiology0.89169015
64MP0005377_hearing/vestibular/ear_phenot0.89169015
65MP0000358_abnormal_cell_content/0.87654923
66MP0006035_abnormal_mitochondrial_morpho0.87141995
67MP0003195_calcinosis0.84036011
68MP0006276_abnormal_autonomic_nervous0.83028824
69MP0001764_abnormal_homeostasis0.82602594
70MP0003329_amyloid_beta_deposits0.79203830
71MP0002102_abnormal_ear_morphology0.77482709
72MP0004185_abnormal_adipocyte_glucose0.75648792
73MP0008872_abnormal_physiological_respon0.74734545
74MP0005253_abnormal_eye_physiology0.74345801
75MP0005636_abnormal_mineral_homeostasis0.73157353
76MP0000367_abnormal_coat/_hair0.72748107
77MP0001216_abnormal_epidermal_layer0.72597731
78MP0006072_abnormal_retinal_apoptosis0.72549493
79MP0001731_abnormal_postnatal_growth0.72212062
80MP0000230_abnormal_systemic_arterial0.70940856
81MP0002970_abnormal_white_adipose0.67279540
82MP0003693_abnormal_embryo_hatching0.67169198
83MP0000566_synostosis0.66713027
84MP0009250_abnormal_appendicular_skeleto0.66476711
85MP0004147_increased_porphyrin_level0.65108708
86MP0003699_abnormal_female_reproductive0.64952345
87MP0008058_abnormal_DNA_repair0.62349573
88MP0001440_abnormal_grooming_behavior0.60042355
89MP0001545_abnormal_hematopoietic_system0.59369267
90MP0005397_hematopoietic_system_phenotyp0.59369267
91MP0004019_abnormal_vitamin_homeostasis0.59328735
92MP0009046_muscle_twitch0.58813667
93MP0010094_abnormal_chromosome_stability0.58789981
94MP0004085_abnormal_heartbeat0.58655925
95MP0003632_abnormal_nervous_system0.57874138
96MP0001485_abnormal_pinna_reflex0.57815871
97MP0001919_abnormal_reproductive_system0.57741949
98MP0000678_abnormal_parathyroid_gland0.57506088
99MP0002161_abnormal_fertility/fecundity0.57471519
100MP0001765_abnormal_ion_homeostasis0.56338714

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)6.16183447
2Reticulocytopenia (HP:0001896)5.40024330
3Amelogenesis imperfecta (HP:0000705)4.93461662
4Hyperglycinemia (HP:0002154)4.63709486
5Vacuolated lymphocytes (HP:0001922)4.48666493
6Wrist flexion contracture (HP:0001239)4.37961449
7Abnormality of dental color (HP:0011073)4.18955281
8Woolly hair (HP:0002224)3.83576644
9Aplasia cutis congenita (HP:0001057)3.82776101
10Duplicated collecting system (HP:0000081)3.70816113
11Abnormal sex determination (HP:0012244)3.69378010
12Sex reversal (HP:0012245)3.69378010
13Abnormality of the renal collecting system (HP:0004742)3.65755940
14Abnormality of DNA repair (HP:0003254)3.65294855
15Broad metatarsal (HP:0001783)3.51225518
16Congenital stationary night blindness (HP:0007642)3.49282312
17Ankle contracture (HP:0006466)3.44136551
18Severe visual impairment (HP:0001141)3.32356223
19Ectopic kidney (HP:0000086)3.27217801
20Hyperglycinuria (HP:0003108)3.25642144
21Bile duct proliferation (HP:0001408)3.22465920
22Abnormal biliary tract physiology (HP:0012439)3.22465920
23Abnormality of the parietal bone (HP:0002696)3.21484031
24Abnormality of the frontal sinuses (HP:0002687)3.18125288
25Abnormality of serine family amino acid metabolism (HP:0010894)3.18045356
26Abnormality of glycine metabolism (HP:0010895)3.18045356
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17003432
28Fragile nails (HP:0001808)3.11511508
29Impulsivity (HP:0100710)3.09302958
30Chromsome breakage (HP:0040012)3.05437525
31Renal salt wasting (HP:0000127)3.05094583
32True hermaphroditism (HP:0010459)2.95913053
33Abnormality of pyrimidine metabolism (HP:0004353)2.87902224
34Hip contracture (HP:0003273)2.87208265
35Narrow nasal bridge (HP:0000446)2.85521708
36Duplication of thumb phalanx (HP:0009942)2.77087596
37Abnormality of cells of the erythroid lineage (HP:0012130)2.73455886
38Failure to thrive in infancy (HP:0001531)2.67467501
39Abnormal pupillary function (HP:0007686)2.66472612
40Oligodactyly (hands) (HP:0001180)2.64936043
41Pancreatic cysts (HP:0001737)2.63279872
42Molar tooth sign on MRI (HP:0002419)2.59519285
43Abnormality of midbrain morphology (HP:0002418)2.59519285
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57720495
45Ureteral duplication (HP:0000073)2.54262019
46Abnormal number of erythroid precursors (HP:0012131)2.42611500
47Decreased central vision (HP:0007663)2.42413724
48Triphalangeal thumb (HP:0001199)2.40181241
49Nephronophthisis (HP:0000090)2.39805772
50Fibular aplasia (HP:0002990)2.39316222
51Absent thumb (HP:0009777)2.39137263
52Pallor (HP:0000980)2.37511194
53Protrusio acetabuli (HP:0003179)2.36331190
54Hyperaldosteronism (HP:0000859)2.34720696
55Abnormal rod and cone electroretinograms (HP:0008323)2.34226369
56Congenital, generalized hypertrichosis (HP:0004540)2.33456814
57Absent forearm bone (HP:0003953)2.29160208
58Aplasia involving forearm bones (HP:0009822)2.29160208
59Short clavicles (HP:0000894)2.28894908
60Absent radius (HP:0003974)2.27906117
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26299759
62Epiphyseal dysplasia (HP:0002656)2.26292684
63Pancreatic fibrosis (HP:0100732)2.20065090
64Tubular atrophy (HP:0000092)2.18296293
65Widely patent fontanelles and sutures (HP:0004492)2.17871515
66Aplasia/Hypoplasia of the clavicles (HP:0006710)2.15581768
67Abnormality of the dental root (HP:0006486)2.13700925
68Taurodontia (HP:0000679)2.13700925
69Abnormality of permanent molar morphology (HP:0011071)2.13700925
70Abnormality of the preputium (HP:0100587)2.13106599
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.11843953
72Depressed nasal tip (HP:0000437)2.11630723
73Tetany (HP:0001281)2.09608853
74Clubbing of toes (HP:0100760)2.07575882
75Tachypnea (HP:0002789)2.06856306
76Abolished electroretinogram (ERG) (HP:0000550)2.05980142
77Aplasia/Hypoplasia of the spleen (HP:0010451)2.03697585
78Male pseudohermaphroditism (HP:0000037)1.98647937
79Abnormality of molar morphology (HP:0011070)1.98094311
80Abnormality of molar (HP:0011077)1.98094311
81Bulbous nose (HP:0000414)1.97632636
82Abnormality of the renal medulla (HP:0100957)1.94493595
83Abnormality of the proximal phalanges of the hand (HP:0009834)1.94082345
84Retinal atrophy (HP:0001105)1.89980204
85Microvesicular hepatic steatosis (HP:0001414)1.89913623
86Asplenia (HP:0001746)1.89681707
87Abnormality of the dental pulp (HP:0006479)1.89124798
88Abnormality of the renal cortex (HP:0011035)1.87956356
89Attenuation of retinal blood vessels (HP:0007843)1.85653132
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84091728
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.82395586
92Bony spicule pigmentary retinopathy (HP:0007737)1.81510362
93Meckel diverticulum (HP:0002245)1.79487108
94Widely spaced teeth (HP:0000687)1.79482221
95Limited hip movement (HP:0008800)1.77715523
96Hemiparesis (HP:0001269)1.76357453
97Cystic liver disease (HP:0006706)1.75975859
98Horseshoe kidney (HP:0000085)1.74856308
99Macrocytic anemia (HP:0001972)1.73283669
100Skin nodule (HP:0200036)1.72901362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.23238202
2INSRR5.14983044
3MST44.18288410
4GRK13.60919649
5NME13.45248489
6ICK3.17770336
7WEE12.81126247
8PTK2B2.61335840
9MAP4K22.51759659
10ADRBK22.42600040
11TESK21.89149212
12RPS6KB21.87010529
13MUSK1.79373981
14PBK1.75706952
15TAOK31.71679912
16TYRO31.70817280
17BRSK21.68188116
18PRKD21.56004303
19PIM11.49328386
20GSK3A1.45330255
21MAP3K41.44630173
22EIF2AK31.43571520
23FRK1.33262298
24MAP3K71.32878202
25MAP2K11.21415565
26PASK1.19528417
27AKT21.10271919
28LATS11.03234273
29IKBKB1.01797555
30LRRK21.01154541
31DDR20.95323149
32PRKCI0.94122190
33NTRK30.93656120
34PLK30.93437795
35STK380.93424880
36TGFBR10.86972917
37STK100.83882339
38MAP3K120.80192898
39BMX0.78363032
40RPS6KA60.76869542
41STK390.75266170
42BMPR20.75120065
43DYRK1A0.74843895
44EIF2AK10.74574346
45ADRBK10.73698006
46KSR20.72669891
47MAPK150.72374715
48PINK10.70318620
49KSR10.69497542
50WNK40.68741102
51RPS6KC10.66749256
52RPS6KL10.66749256
53PLK40.65846670
54KDR0.65118328
55TRIM280.64447668
56EPHA20.63260303
57STK160.62329009
58PNCK0.62270480
59YES10.58940603
60TNIK0.57928601
61CSNK1A10.56587752
62DYRK20.55204483
63PLK20.51244072
64OXSR10.48695417
65MYLK0.47290884
66ROCK20.45224542
67PAK30.44273284
68TBK10.43937114
69STK110.43318299
70PLK10.43198523
71NEK60.41688952
72MAPK10.41006770
73MAPK120.40763139
74BCKDK0.39898473
75PHKG10.39830218
76PHKG20.39830218
77MAP2K20.39696856
78CDK30.36987443
79VRK10.35769056
80LYN0.35305025
81MAP3K90.35240627
82FGFR30.33236967
83MATK0.33135306
84ROCK10.32851126
85CDK70.32837057
86PRKACA0.32732184
87RPS6KA10.30142583
88MAPK130.29738048
89INSR0.29617305
90MAPK30.29530952
91SGK10.29521470
92BRAF0.28093310
93PRKCZ0.27818400
94LMTK20.27628025
95PRKCH0.25376372
96PRKCE0.25133187
97CAMK10.24581444
98PRKCA0.24273263
99PRKD10.23150409
100GRK60.22889520

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.54086154
2Autoimmune thyroid disease_Homo sapiens_hsa053203.64022442
3Ribosome_Homo sapiens_hsa030102.81465110
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.79478778
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.71305714
6Thyroid hormone synthesis_Homo sapiens_hsa049182.55125143
7p53 signaling pathway_Homo sapiens_hsa041152.28594210
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.20634111
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04977153
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99102824
11Basal transcription factors_Homo sapiens_hsa030221.96190664
12Ras signaling pathway_Homo sapiens_hsa040141.83530810
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74826448
14Linoleic acid metabolism_Homo sapiens_hsa005911.74391360
15GnRH signaling pathway_Homo sapiens_hsa049121.73508212
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72290605
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70054158
18Rap1 signaling pathway_Homo sapiens_hsa040151.65666431
19HIF-1 signaling pathway_Homo sapiens_hsa040661.65180797
20Vitamin digestion and absorption_Homo sapiens_hsa049771.64698285
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62420600
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61655570
23Prolactin signaling pathway_Homo sapiens_hsa049171.59438942
24RNA degradation_Homo sapiens_hsa030181.57408494
25N-Glycan biosynthesis_Homo sapiens_hsa005101.56658694
26Phototransduction_Homo sapiens_hsa047441.55382860
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49185604
28Fanconi anemia pathway_Homo sapiens_hsa034601.43163694
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.42757003
30Hedgehog signaling pathway_Homo sapiens_hsa043401.38747263
31Basal cell carcinoma_Homo sapiens_hsa052171.38443041
32Chemical carcinogenesis_Homo sapiens_hsa052041.32315139
33Other glycan degradation_Homo sapiens_hsa005111.30655899
34Nitrogen metabolism_Homo sapiens_hsa009101.29204842
35Ether lipid metabolism_Homo sapiens_hsa005651.24598047
36Antigen processing and presentation_Homo sapiens_hsa046121.23944048
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.21961286
38Proteasome_Homo sapiens_hsa030501.18195636
39Caffeine metabolism_Homo sapiens_hsa002321.08201215
40Arginine and proline metabolism_Homo sapiens_hsa003301.08095377
41RNA polymerase_Homo sapiens_hsa030201.07330045
42Protein export_Homo sapiens_hsa030601.02770144
43Selenocompound metabolism_Homo sapiens_hsa004501.00783419
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98477124
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.87799261
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87276345
47Bladder cancer_Homo sapiens_hsa052190.86685137
48Cardiac muscle contraction_Homo sapiens_hsa042600.85504074
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.83971681
50Cell cycle_Homo sapiens_hsa041100.83255752
51Protein digestion and absorption_Homo sapiens_hsa049740.80124777
52Arachidonic acid metabolism_Homo sapiens_hsa005900.76714055
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76667468
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75672004
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75585105
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74799506
57Primary immunodeficiency_Homo sapiens_hsa053400.72939005
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72650383
59Propanoate metabolism_Homo sapiens_hsa006400.71429952
60Spliceosome_Homo sapiens_hsa030400.67887369
61Pathways in cancer_Homo sapiens_hsa052000.67350066
62Small cell lung cancer_Homo sapiens_hsa052220.65145478
63Oocyte meiosis_Homo sapiens_hsa041140.63655969
64FoxO signaling pathway_Homo sapiens_hsa040680.62183811
65Taste transduction_Homo sapiens_hsa047420.58600860
66Olfactory transduction_Homo sapiens_hsa047400.58348989
67Glutathione metabolism_Homo sapiens_hsa004800.56848467
68Base excision repair_Homo sapiens_hsa034100.56513788
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56056212
70Non-homologous end-joining_Homo sapiens_hsa034500.55475573
71Hippo signaling pathway_Homo sapiens_hsa043900.55431218
72Pyrimidine metabolism_Homo sapiens_hsa002400.55072351
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52038820
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.50579572
75Nucleotide excision repair_Homo sapiens_hsa034200.50570963
76Prostate cancer_Homo sapiens_hsa052150.48198718
77RNA transport_Homo sapiens_hsa030130.46678225
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45426461
79Histidine metabolism_Homo sapiens_hsa003400.44719387
80Oxidative phosphorylation_Homo sapiens_hsa001900.43973636
81Collecting duct acid secretion_Homo sapiens_hsa049660.43705242
82Regulation of autophagy_Homo sapiens_hsa041400.40445345
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38738036
84Tight junction_Homo sapiens_hsa045300.38692761
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.36899915
86Tryptophan metabolism_Homo sapiens_hsa003800.36586634
87Fat digestion and absorption_Homo sapiens_hsa049750.35465899
88Notch signaling pathway_Homo sapiens_hsa043300.35236760
89Metabolic pathways_Homo sapiens_hsa011000.33682409
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30841529
91Bile secretion_Homo sapiens_hsa049760.29836680
92Inositol phosphate metabolism_Homo sapiens_hsa005620.29389356
93Measles_Homo sapiens_hsa051620.25732172
94Mineral absorption_Homo sapiens_hsa049780.23276919
95Sulfur relay system_Homo sapiens_hsa041220.22611528
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22178330
97Type II diabetes mellitus_Homo sapiens_hsa049300.22120155
98Huntingtons disease_Homo sapiens_hsa050160.22026328
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.21528494
100Peroxisome_Homo sapiens_hsa041460.20097147

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