GPR34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)8.20113747
2G-protein coupled purinergic receptor signaling pathway (GO:0035588)6.89292326
3macrophage activation involved in immune response (GO:0002281)6.78034349
4purinergic nucleotide receptor signaling pathway (GO:0035590)6.67948698
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54227896
6negative regulation of granulocyte differentiation (GO:0030853)6.34628468
7regulation of chemokine secretion (GO:0090196)6.28783469
8eosinophil chemotaxis (GO:0048245)6.26556376
9positive regulation of myeloid leukocyte mediated immunity (GO:0002888)6.00007539
10macrophage activation (GO:0042116)5.89695807
11regulation of interferon-beta biosynthetic process (GO:0045357)5.83231262
12regulation of mononuclear cell migration (GO:0071675)5.73445494
13adenosine receptor signaling pathway (GO:0001973)5.73104973
14eosinophil migration (GO:0072677)5.65174832
15glycosphingolipid catabolic process (GO:0046479)5.51861305
16oligosaccharide catabolic process (GO:0009313)5.49223764
17regulation of hypersensitivity (GO:0002883)5.47791852
18purinergic receptor signaling pathway (GO:0035587)5.29266818
19negative regulation of norepinephrine secretion (GO:0010700)5.00747274
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.97163325
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.97163325
22modulation by symbiont of host immune response (GO:0052553)4.97163325
23positive regulation by symbiont of host defense response (GO:0052509)4.97163325
24modulation by symbiont of host defense response (GO:0052031)4.97163325
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.97163325
26glycolipid catabolic process (GO:0019377)4.95049263
27regulation of B cell receptor signaling pathway (GO:0050855)4.87493084
28positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.65022320
29positive regulation of mast cell activation involved in immune response (GO:0033008)4.64345360
30positive regulation of mast cell degranulation (GO:0043306)4.64345360
31keratan sulfate catabolic process (GO:0042340)4.58575568
32detection of molecule of bacterial origin (GO:0032490)4.56195644
33chondroitin sulfate catabolic process (GO:0030207)4.51461722
34phagocytosis, recognition (GO:0006910)4.49363580
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.48689780
36phagocytosis, engulfment (GO:0006911)4.46911745
37ceramide catabolic process (GO:0046514)4.41454333
38positive regulation of interferon-alpha production (GO:0032727)4.26461077
39positive regulation of mast cell activation (GO:0033005)4.25256847
40regulation of T-helper 2 cell differentiation (GO:0045628)4.16594140
41negative regulation of tissue remodeling (GO:0034104)4.16593087
42amino sugar catabolic process (GO:0046348)4.13593513
43negative regulation of interleukin-12 production (GO:0032695)4.12591838
44regulation of myeloid leukocyte mediated immunity (GO:0002886)4.07578447
45hyaluronan catabolic process (GO:0030214)4.05692072
46regulation of interferon-alpha production (GO:0032647)4.05210871
47regulation of cholesterol storage (GO:0010885)4.01482664
48regulation of chemokine-mediated signaling pathway (GO:0070099)3.88918520
49myeloid cell activation involved in immune response (GO:0002275)3.87322739
50response to muramyl dipeptide (GO:0032495)3.86760533
51positive regulation of leukocyte degranulation (GO:0043302)3.81472916
52positive regulation of antigen processing and presentation (GO:0002579)3.78680629
53regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.76949686
54regulation of macrophage chemotaxis (GO:0010758)3.75508019
55negative regulation of bone resorption (GO:0045779)3.74190093
56neutrophil activation involved in immune response (GO:0002283)3.73466665
57cellular response to thyroid hormone stimulus (GO:0097067)3.72107179
58N-acetylneuraminate metabolic process (GO:0006054)3.70839878
59B cell mediated immunity (GO:0019724)3.70236192
60positive regulation of B cell differentiation (GO:0045579)3.69038149
61negative regulation of interleukin-6 production (GO:0032715)3.63464953
62monocyte differentiation (GO:0030224)3.58380048
63tolerance induction (GO:0002507)3.57963230
64macrophage chemotaxis (GO:0048246)3.54938409
65detection of external biotic stimulus (GO:0098581)3.53694972
66cellular response to ethanol (GO:0071361)3.51809638
67I-kappaB phosphorylation (GO:0007252)3.50384751
68ruffle organization (GO:0031529)3.47332758
69macrophage differentiation (GO:0030225)3.46292149
70cyclooxygenase pathway (GO:0019371)3.43598026
71positive regulation of gamma-delta T cell activation (GO:0046645)3.39328142
72interferon-gamma-mediated signaling pathway (GO:0060333)3.37762512
73pathway-restricted SMAD protein phosphorylation (GO:0060389)3.37662908
74regulation of mast cell activation (GO:0033003)3.32300022
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31492343
76monocyte chemotaxis (GO:0002548)3.28119251
77regulation of monocyte chemotaxis (GO:0090025)3.27568686
78cellular extravasation (GO:0045123)3.26250102
79regulation of inflammatory response to antigenic stimulus (GO:0002861)3.26061574
80T-helper 1 type immune response (GO:0042088)3.24608990
81positive regulation of smooth muscle cell migration (GO:0014911)3.23144776
82lysosome organization (GO:0007040)3.22891070
83lytic vacuole organization (GO:0080171)3.22891070
84adaptation of signaling pathway (GO:0023058)3.21010058
85myeloid leukocyte activation (GO:0002274)3.17375175
86Rac protein signal transduction (GO:0016601)3.15040051
87positive regulation of monocyte chemotaxis (GO:0090026)3.14302564
88regulation of granulocyte differentiation (GO:0030852)3.13706863
89detection of biotic stimulus (GO:0009595)3.11571518
90positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.11283889
91negative regulation of cell killing (GO:0031342)3.11147800
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11147800
93membrane invagination (GO:0010324)3.09604243
94adhesion of symbiont to host cell (GO:0044650)3.08689370
95virion attachment to host cell (GO:0019062)3.08689370
96positive regulation of macrophage cytokine production (GO:0060907)3.08207984
97negative regulation of multicellular organism growth (GO:0040015)3.08033268
98detection of other organism (GO:0098543)3.07831111
99response to cholesterol (GO:0070723)3.07239577
100negative regulation of B cell proliferation (GO:0030889)3.05192987
101positive regulation of cellular amide metabolic process (GO:0034250)3.04639232
102negative regulation of systemic arterial blood pressure (GO:0003085)3.03894281
103mannose metabolic process (GO:0006013)3.03790894
104sodium-independent organic anion transport (GO:0043252)3.03305907
105glial cell migration (GO:0008347)3.03270128
106positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.03137476
107regulation of leukocyte degranulation (GO:0043300)3.02681828
108barbed-end actin filament capping (GO:0051016)3.02261503
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.02209875
110ganglioside metabolic process (GO:0001573)3.02207078
111regulation of antigen processing and presentation (GO:0002577)2.98927513
112positive regulation of phagocytosis (GO:0050766)2.97885338
113response to host (GO:0075136)2.95891687
114response to host defenses (GO:0052200)2.95891687
115response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95891687
116negative regulation of bone remodeling (GO:0046851)2.95818078
117negative regulation of catecholamine secretion (GO:0033604)2.95442461
118adhesion of symbiont to host (GO:0044406)2.95212701
119germ cell migration (GO:0008354)2.95205996
120positive regulation of type 2 immune response (GO:0002830)2.94205269
121histamine secretion (GO:0001821)2.94126427
122regulation of mast cell activation involved in immune response (GO:0033006)2.91894570
123granulocyte chemotaxis (GO:0071621)2.91637611
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86097192
125response to host immune response (GO:0052572)2.85532186
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85532186
127complement activation, alternative pathway (GO:0006957)2.84049155
128phosphatidylglycerol biosynthetic process (GO:0006655)2.83156995
129regulation of T-helper 1 cell differentiation (GO:0045625)2.82822444
130positive regulation of calcium-mediated signaling (GO:0050850)2.82374576
131positive regulation of interferon-beta production (GO:0032728)2.81686895
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81120913
133regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.80740475
134regulation of mast cell degranulation (GO:0043304)2.80184199
135granulocyte migration (GO:0097530)2.80067441
136regulation of B cell differentiation (GO:0045577)2.77635631
137regulation of type 2 immune response (GO:0002828)2.77459877
138regulation of T cell tolerance induction (GO:0002664)2.76588379
139negative regulation of T-helper cell differentiation (GO:0045623)2.76272610
140negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76272610
141positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75674632
142positive regulation of cholesterol efflux (GO:0010875)2.75288470
143pinocytosis (GO:0006907)2.74682879
144B cell receptor signaling pathway (GO:0050853)2.74015751
145immunoglobulin mediated immune response (GO:0016064)2.73446364
146lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73015174
147positive regulation of acute inflammatory response (GO:0002675)2.72711800
148negative regulation of osteoclast differentiation (GO:0045671)2.72541758
149response to peptidoglycan (GO:0032494)2.71551583
150positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69851417
151mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.69679869
152negative regulation of leukocyte chemotaxis (GO:0002689)2.68478501
153cellular response to interferon-gamma (GO:0071346)2.68321994
154apoptotic cell clearance (GO:0043277)2.67720368
155regulation of monocyte differentiation (GO:0045655)2.67149369
156granulocyte activation (GO:0036230)2.67122563
157regulation of interleukin-2 biosynthetic process (GO:0045076)2.66037612
158negative regulation of macrophage differentiation (GO:0045650)2.65626500
159G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)10.4252156
160microglial cell activation (GO:0001774)10.2866796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.99222902
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.28343072
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.50541809
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.16991616
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.57047908
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18648636
7SCL_19346495_ChIP-Seq_HPC-7_Human3.09773804
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93667029
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.92164903
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72716297
11RUNX_20019798_ChIP-Seq_JUKART_Human2.62482992
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56263911
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54755556
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51887549
15SPI1_23127762_ChIP-Seq_K562_Human2.46989518
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45015720
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36042251
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01982238
19VDR_24787735_ChIP-Seq_THP-1_Human1.94243126
20GATA1_22025678_ChIP-Seq_K562_Human1.90378962
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90053602
22PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83959523
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82925333
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.80084639
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78697089
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78113555
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76487901
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74553269
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72224745
30VDR_24763502_ChIP-Seq_THP-1_Human1.69099054
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62120658
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57862580
33SPI1_23547873_ChIP-Seq_NB4_Human1.55653170
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.52097386
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51468138
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50449675
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49539168
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.47326710
39PU_27001747_Chip-Seq_BMDM_Mouse1.44470953
40EGR1_19032775_ChIP-ChIP_M12_Human1.44037147
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42932752
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37560258
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33854525
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29396856
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28606299
46TCF7_22412390_ChIP-Seq_EML_Mouse1.28428602
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.28139941
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26059394
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25117450
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20972805
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.18824016
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18216883
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17349221
54MYB_26560356_Chip-Seq_TH2_Human1.16013782
55GATA2_19941826_ChIP-Seq_K562_Human1.15647141
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.14027647
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13387990
58DROSHA_22980978_ChIP-Seq_HELA_Human1.10670236
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.08975816
60GATA1_19941826_ChIP-Seq_K562_Human1.06461332
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05712087
62MAF_26560356_Chip-Seq_TH1_Human1.04377643
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03577646
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03261338
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02982519
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02982519
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02982519
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02709426
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02635108
70VDR_21846776_ChIP-Seq_THP-1_Human1.01354996
71GATA1_19941827_ChIP-Seq_MEL_Mouse0.99828979
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.99620348
73NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97352839
74STAT1_20625510_ChIP-Seq_HELA_Human0.97300715
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97099213
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96302506
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95412253
78MYB_26560356_Chip-Seq_TH1_Human0.89772469
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88526910
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88315070
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88126651
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87863767
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86166193
84GATA3_27048872_Chip-Seq_THYMUS_Human0.86014833
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85558064
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84807063
87* SMRT_27268052_Chip-Seq_Bcells_Human0.83997185
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83817459
89CJUN_26792858_Chip-Seq_BT549_Human0.82949569
90UTX_26944678_Chip-Seq_JUKART_Human0.82719403
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82368087
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81671332
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81581897
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81477592
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.81425438
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80525038
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.80468980
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79958805
99KDM2B_26808549_Chip-Seq_DND41_Human0.78683137
100GATA3_26560356_Chip-Seq_TH2_Human0.78676573
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78436354
102LXR_22292898_ChIP-Seq_THP-1_Human0.76362078
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.75628099
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.75055698
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74982805
106SOX2_20726797_ChIP-Seq_SW620_Human0.74527621
107AHR_22903824_ChIP-Seq_MCF-7_Human0.74459725
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72233705
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72209680
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72115643
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.71674426
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71537326
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71427100
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71427100
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71379989
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71379989
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71362482
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.71194267
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.70853684
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70592296
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69885784
122ELK4_26923725_Chip-Seq_MESODERM_Mouse0.69634035
123VDR_22108803_ChIP-Seq_LS180_Human0.69471752
124EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69137558
125TFEB_21752829_ChIP-Seq_HELA_Human0.68078079
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.67907053
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.67403038
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.67226467
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66732653
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66561085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.70666807
2MP0003191_abnormal_cellular_cholesterol5.50649366
3MP0005058_abnormal_lysosome_morphology4.51842230
4MP0001835_abnormal_antigen_presentation3.96988317
5MP0005671_abnormal_response_to3.68854803
6MP0003172_abnormal_lysosome_physiology3.49319566
7MP0003690_abnormal_glial_cell3.46895676
8MP0005464_abnormal_platelet_physiology3.22642242
9MP0003303_peritoneal_inflammation3.01807971
10MP0009840_abnormal_foam_cell3.00131977
11MP0002148_abnormal_hypersensitivity_rea2.80288182
12MP0003075_altered_response_to2.54056000
13MP0002419_abnormal_innate_immunity2.52127141
14MP0003724_increased_susceptibility_to2.25497539
15MP0008004_abnormal_stomach_pH2.25377161
16MP0005000_abnormal_immune_tolerance2.24183287
17MP0002452_abnormal_antigen_presenting2.18766512
18MP0004883_abnormal_blood_vessel2.10758053
19MP0003252_abnormal_bile_duct2.06662029
20MP0001800_abnormal_humoral_immune2.02532774
21MP0003436_decreased_susceptibility_to1.98586554
22MP0002723_abnormal_immune_serum1.97323846
23MP0001819_abnormal_immune_cell1.75712196
24MP0002420_abnormal_adaptive_immunity1.72235663
25MP0001533_abnormal_skeleton_physiology1.69699085
26MP0003195_calcinosis1.69644744
27MP0005166_decreased_susceptibility_to1.69225377
28MP0001851_eye_inflammation1.69217662
29MP0005025_abnormal_response_to1.65144122
30MP0002928_abnormal_bile_duct1.64420393
31MP0000343_altered_response_to1.63914344
32MP0000465_gastrointestinal_hemorrhage1.63748773
33MP0002254_reproductive_system_inflammat1.60889102
34MP0003279_aneurysm1.56369003
35MP0003300_gastrointestinal_ulcer1.54176731
36MP0005167_abnormal_blood-brain_barrier1.54067637
37MP0003329_amyloid_beta_deposits1.51315440
38MP0005310_abnormal_salivary_gland1.49688777
39MP0002090_abnormal_vision1.48591645
40MP0003045_fibrosis1.45200639
41MP0002998_abnormal_bone_remodeling1.45095852
42MP0000920_abnormal_myelination1.44679107
43MP0005451_abnormal_body_composition1.43918879
44MP0009785_altered_susceptibility_to1.43480809
45MP0005387_immune_system_phenotype1.38925311
46MP0001790_abnormal_immune_system1.38925311
47MP0009333_abnormal_splenocyte_physiolog1.38227986
48MP0008469_abnormal_protein_level1.37712931
49MP0005360_urolithiasis1.33512954
50MP0004510_myositis1.32815276
51MP0008007_abnormal_cellular_replicative1.31761371
52MP0001845_abnormal_inflammatory_respons1.30450461
53MP0002405_respiratory_system_inflammati1.29731475
54MP0005670_abnormal_white_adipose1.29109479
55MP0005365_abnormal_bile_salt1.28189530
56MP0001915_intracranial_hemorrhage1.27196083
57MP0000716_abnormal_immune_system1.24294761
58MP0003183_abnormal_peptide_metabolism1.19874883
59MP0000249_abnormal_blood_vessel1.18498601
60MP0000689_abnormal_spleen_morphology1.15968351
61MP0004130_abnormal_muscle_cell1.15601690
62MP0003633_abnormal_nervous_system1.15024701
63MP0005397_hematopoietic_system_phenotyp1.14459970
64MP0001545_abnormal_hematopoietic_system1.14459970
65MP0002139_abnormal_hepatobiliary_system1.13724516
66MP0005164_abnormal_response_to1.11327263
67MP0002396_abnormal_hematopoietic_system1.10524766
68MP0000685_abnormal_immune_system1.10286447
69MP0000767_abnormal_smooth_muscle1.08481496
70MP0005165_increased_susceptibility_to1.05464987
71MP0002398_abnormal_bone_marrow1.02943819
72MP0005084_abnormal_gallbladder_morpholo1.01593435
73MP0001853_heart_inflammation0.98951136
74MP0002722_abnormal_immune_system0.98944784
75MP0005085_abnormal_gallbladder_physiolo0.97108832
76MP0003632_abnormal_nervous_system0.96477537
77MP0003828_pulmonary_edema0.95561491
78MP0002429_abnormal_blood_cell0.94084633
79MP0008874_decreased_physiological_sensi0.91796083
80MP0008873_increased_physiological_sensi0.91011533
81MP0005174_abnormal_tail_pigmentation0.89314387
82MP0004947_skin_inflammation0.83416728
83MP0009115_abnormal_fat_cell0.82942114
84MP0000015_abnormal_ear_pigmentation0.79832128
85MP0002166_altered_tumor_susceptibility0.79684279
86MP0010155_abnormal_intestine_physiology0.77918488
87MP0000604_amyloidosis0.76933376
88MP0010386_abnormal_urinary_bladder0.76336324
89MP0004484_altered_response_of0.75851947
90MP0005584_abnormal_enzyme/coenzyme_acti0.75593552
91MP0003634_abnormal_glial_cell0.75516411
92MP0001986_abnormal_taste_sensitivity0.75270420
93MP0001873_stomach_inflammation0.75246527
94MP0002971_abnormal_brown_adipose0.74505988
95MP0002277_abnormal_respiratory_mucosa0.74175347
96MP0006054_spinal_hemorrhage0.71686802
97MP0002736_abnormal_nociception_after0.71114775
98MP0000858_altered_metastatic_potential0.70574348
99MP0003566_abnormal_cell_adhesion0.69841976
100MP0009278_abnormal_bone_marrow0.69814183
101MP0005390_skeleton_phenotype0.69242327
102MP0005666_abnormal_adipose_tissue0.69175681
103MP0009764_decreased_sensitivity_to0.67414439
104MP0005647_abnormal_sex_gland0.65791482
105MP0001542_abnormal_bone_strength0.64387730
106MP0002933_joint_inflammation0.64344679
107MP0009384_cardiac_valve_regurgitation0.63893875
108MP0004185_abnormal_adipocyte_glucose0.63619427
109MP0005595_abnormal_vascular_smooth0.63401824
110MP0005334_abnormal_fat_pad0.62315337
111MP0004019_abnormal_vitamin_homeostasis0.62222307
112MP0008260_abnormal_autophagy0.61891045
113MP0000609_abnormal_liver_physiology0.61588863
114MP0005197_abnormal_uvea_morphology0.61242231
115MP0000371_diluted_coat_color0.60756563
116MP0005408_hypopigmentation0.60671682
117MP0003795_abnormal_bone_structure0.57907532
118MP0002064_seizures0.57485985
119MP0002136_abnormal_kidney_physiology0.57477070
120MP0009763_increased_sensitivity_to0.57168952
121MP0002135_abnormal_kidney_morphology0.56502501
122MP0002006_tumorigenesis0.55657361
123MP0000569_abnormal_digit_pigmentation0.54443354
124MP0003631_nervous_system_phenotype0.54248720
125MP0003763_abnormal_thymus_physiology0.48236282
126MP0003448_altered_tumor_morphology0.47930289

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)9.42894205
2Complement deficiency (HP:0004431)7.62390161
3Abnormality of liposaccharide metabolism (HP:0010968)6.84319700
4Abnormality of glycosphingolipid metabolism (HP:0004343)6.84319700
5Abnormality of glycolipid metabolism (HP:0010969)6.84319700
6Abnormality of complement system (HP:0005339)5.63476695
7Arterial tortuosity (HP:0005116)5.25085783
8Retinal atrophy (HP:0001105)4.69975714
9Nephritis (HP:0000123)4.64592851
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.60974536
11Vascular tortuosity (HP:0004948)4.58433447
12Increased cerebral lipofuscin (HP:0011813)4.56454303
13Urethral obstruction (HP:0000796)4.53097818
14Recurrent abscess formation (HP:0002722)4.33534182
15Mutism (HP:0002300)4.32260252
16Recurrent bacterial skin infections (HP:0005406)4.31268205
17Cerebral aneurysm (HP:0004944)4.24976427
18Disinhibition (HP:0000734)4.13452935
19Axonal loss (HP:0003447)3.86288560
20Dysostosis multiplex (HP:0000943)3.70638323
21Chronic diarrhea (HP:0002028)3.68349319
22Orthostatic hypotension (HP:0001278)3.62159250
23Agnosia (HP:0010524)3.58209499
24Upper motor neuron abnormality (HP:0002127)3.46990146
25Hematochezia (HP:0002573)3.43106486
26Loss of speech (HP:0002371)3.40321684
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.38311715
28Eczematoid dermatitis (HP:0000976)3.37970226
29Pustule (HP:0200039)3.35747037
30Aortic aneurysm (HP:0004942)3.34683918
31Premature loss of primary teeth (HP:0006323)3.21555652
32Gingivitis (HP:0000230)3.19875450
33Progressive neurologic deterioration (HP:0002344)3.18327852
34Abnormal platelet function (HP:0011869)3.12754248
35Impaired platelet aggregation (HP:0003540)3.12754248
36Mediastinal lymphadenopathy (HP:0100721)3.08586342
37Amyloidosis (HP:0011034)3.01368039
38Partial duplication of thumb phalanx (HP:0009944)2.96069349
39Disproportionate tall stature (HP:0001519)2.88278269
40Colitis (HP:0002583)2.85352753
41Neuronal loss in central nervous system (HP:0002529)2.82713818
42Recurrent cutaneous fungal infections (HP:0011370)2.79110210
43Chronic mucocutaneous candidiasis (HP:0002728)2.79110210
44Autoimmune thrombocytopenia (HP:0001973)2.78378979
45Striae distensae (HP:0001065)2.71140524
46Abnormality of the vasculature of the conjunctiva (HP:0008054)2.68784880
47Prostate neoplasm (HP:0100787)2.68413706
48Split foot (HP:0001839)2.66071489
49Hepatosplenomegaly (HP:0001433)2.65084509
50Intestinal atresia (HP:0011100)2.62809333
51Mucopolysacchariduria (HP:0008155)2.61777626
52Urinary glycosaminoglycan excretion (HP:0003541)2.61777626
53Vacuolated lymphocytes (HP:0001922)2.58222854
54Aortic dissection (HP:0002647)2.58132448
55Inappropriate behavior (HP:0000719)2.54633574
56Partial duplication of the phalanx of hand (HP:0009999)2.54145423
57Rectal fistula (HP:0100590)2.48632805
58Rectovaginal fistula (HP:0000143)2.48632805
59Nuclear cataract (HP:0100018)2.48197889
60Abnormality of polysaccharide metabolism (HP:0011012)2.45145922
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45145922
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45145922
63Arnold-Chiari malformation (HP:0002308)2.43564674
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41944466
65Intestinal fistula (HP:0100819)2.39814714
66Myositis (HP:0100614)2.34855635
67Apathy (HP:0000741)2.32387318
68Recurrent skin infections (HP:0001581)2.30089800
69Pathologic fracture (HP:0002756)2.29323835
70Cardiomegaly (HP:0001640)2.28865745
71Recurrent fungal infections (HP:0002841)2.28790944
72Inflammation of the large intestine (HP:0002037)2.23501133
73Diminished motivation (HP:0000745)2.21001477
74Polygenic inheritance (HP:0010982)2.19548948
75Urinary incontinence (HP:0000020)2.17247706
76Purpura (HP:0000979)2.16222453
77Erectile abnormalities (HP:0100639)2.14983851
78Hemoptysis (HP:0002105)2.14651501
79Lower limb asymmetry (HP:0100559)2.14303709
80Vaginal fistula (HP:0004320)2.10797940
81Retrobulbar optic neuritis (HP:0100654)2.10219180
82Optic neuritis (HP:0100653)2.10219180
83Recurrent gram-negative bacterial infections (HP:0005420)2.09742451
84Spontaneous hematomas (HP:0007420)2.08339608
85Neurofibrillary tangles (HP:0002185)2.07915674
86Joint hemorrhage (HP:0005261)2.05224708
87Esophageal neoplasm (HP:0100751)2.04418419
88Neoplasm of head and neck (HP:0012288)2.04418419
89Mitral valve prolapse (HP:0001634)2.04262197
90J-shaped sella turcica (HP:0002680)2.03592765
91Abnormality of the prostate (HP:0008775)2.03248665
92Dementia (HP:0000726)2.02512851
93Progressive visual loss (HP:0000529)2.02418992
94Abnormality of the basal ganglia (HP:0002134)2.02398927
95Osteolytic defects of the hand bones (HP:0009699)2.02014269
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.02014269
97Cerebral inclusion bodies (HP:0100314)2.00211222
98Systemic lupus erythematosus (HP:0002725)10.6474858
99Periodontitis (HP:0000704)1.99438065
100Abnormality of the periventricular white matter (HP:0002518)1.99096890
101Memory impairment (HP:0002354)1.98394523
102Gastrointestinal inflammation (HP:0004386)1.97899545
103Abnormality of macrophages (HP:0004311)1.97724504
104Pulmonary infiltrates (HP:0002113)1.97675913
105Basal ganglia calcification (HP:0002135)1.96665668
106Asymmetric septal hypertrophy (HP:0001670)1.96325080
107Increased CSF protein (HP:0002922)1.94577156
108Orchitis (HP:0100796)1.93966025
109Stomatitis (HP:0010280)1.93715880
110Spinal muscular atrophy (HP:0007269)1.91674956
111Camptodactyly of toe (HP:0001836)1.88564890
112Peripheral demyelination (HP:0011096)1.88415126
113Global brain atrophy (HP:0002283)1.87682061
114Meningitis (HP:0001287)1.86807045
115Elevated erythrocyte sedimentation rate (HP:0003565)1.85990791
116Myocardial infarction (HP:0001658)1.85945718
117Epistaxis (HP:0000421)1.85593611
118Spondylolisthesis (HP:0003302)1.83546642
119Prolonged bleeding time (HP:0003010)1.82194710
120Cheilitis (HP:0100825)1.82001048
121Obstructive lung disease (HP:0006536)1.81923821
122Chronic obstructive pulmonary disease (HP:0006510)1.81923821
123Clumsiness (HP:0002312)1.75916545
124Malnutrition (HP:0004395)1.75801164
125Exotropia (HP:0000577)1.75341017
126Polyneuropathy (HP:0001271)1.74304808
127Abnormal autonomic nervous system physiology (HP:0012332)1.69690621
128Albinism (HP:0001022)1.69642175
129Metaphyseal irregularity (HP:0003025)1.68775035
130IgM deficiency (HP:0002850)1.67522890
131Postural instability (HP:0002172)1.67148165
132Conjunctival telangiectasia (HP:0000524)1.65160284
133Urticaria (HP:0001025)1.63067868
134Bone cyst (HP:0012062)1.62173508
135Petechiae (HP:0000967)1.61838313
136Thick nail (HP:0001805)1.61394720
137Personality changes (HP:0000751)1.60947656
138Bone pain (HP:0002653)1.59671776
139Abnormal large intestine physiology (HP:0012700)1.56777364
140Cellulitis (HP:0100658)1.56067102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.06658768
2PDK24.95480902
3GRK74.03551947
4MAPK153.95385984
5CSF1R3.21654577
6TYK22.64545602
7NEK92.49046808
8NTRK22.07770716
9MAP3K142.06536215
10TSSK62.05599447
11MAPK122.04333289
12BLK1.94613819
13PAK41.88727010
14NEK61.86378223
15IRAK31.85403748
16RIPK41.79669299
17MAPK71.76095877
18TBK11.68198845
19ACVR1B1.60662440
20MATK1.59301820
21JAK31.56012946
22TXK1.51805434
23PKN21.51707913
24JAK11.49661017
25STK101.47665356
26ERN11.40564168
27EPHB11.36075845
28MOS1.35311307
29ZAP701.33991464
30IKBKB1.33413124
31MAP4K11.31496643
32IRAK41.30789653
33CLK11.30653941
34CDC42BPA1.25705146
35BMPR21.21407788
36MAP3K31.14551818
37CSK1.09236427
38TNK21.05538273
39PDK11.05081104
40CAMK1D1.03632618
41JAK21.03275632
42MAP3K91.02441948
43HCK1.01040334
44GRK51.00022339
45ITK0.95379149
46FES0.93668478
47LYN0.93179457
48PAK20.89817433
49KIT0.89127342
50VRK10.88172292
51ADRBK20.83510499
52LCK0.82985068
53DDR20.81977144
54MAP3K110.79448712
55SYK0.77696411
56MAP3K10.77554393
57ABL20.74856082
58TAOK30.73377997
59CAMK1G0.73113752
60SIK20.70075473
61PDPK10.69620312
62RIPK10.69136647
63MAP2K30.65894964
64IKBKE0.65339307
65PTK60.65103931
66EPHB20.63813565
67PIK3CG0.62839268
68IGF1R0.62035481
69MAPKAPK20.59372983
70EIF2AK20.58995366
71MAPKAPK50.58599266
72NME20.58269285
73CAMKK10.57831869
74MAP3K50.57768296
75BTK0.56390922
76TRIM280.55907944
77CDK60.55736493
78MAP2K60.53895389
79EEF2K0.53356209
80FLT30.52040776
81CDK30.52000245
82TEC0.50900069
83CAMKK20.50046924
84DMPK0.48921140
85PRKCQ0.48742897
86CAMK40.48292269
87PDGFRB0.47419563
88GRK10.47250221
89MAP3K60.46780365
90MAP2K40.45703309
91IRAK20.44487228
92OXSR10.43732535
93MAP3K20.43690048
94IRAK10.41957874
95SGK30.41595517
96INSR0.41449641
97PKN10.41144958
98RPS6KA20.39764871
99GSK3A0.39597550
100PRKACG0.38634966
101MAPK40.38168611
102TESK20.36911392
103EGFR0.36298846
104CHUK0.36265844
105SGK20.35693659
106PRKD10.35521758
107FGR0.35157248
108STK30.33788336
109MAP2K20.33550513
110ERBB20.31278995
111ERBB30.31275276
112STK110.30725930
113PRKAA20.29691812
114RET0.28989687
115SRC0.27350918
116HIPK20.27246016
117ADRBK10.26729282
118CASK0.26520066
119CDK80.26402267
120RPS6KL10.26174180
121RPS6KC10.26174180
122ARAF0.25145889
123RPS6KA60.24376943
124MAP3K100.23884800
125MARK30.23410836
126PRKG10.20489006
127MAPKAPK30.19785344
128FYN0.19086957
129ABL10.19012958
130MAP3K130.18352163
131PRKCD0.16194714
132FGFR30.15908553
133YES10.15847416
134CDK90.15676915
135PRKG20.11212288

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.29993715
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.48049047
3Glycosaminoglycan degradation_Homo sapiens_hsa005314.30160661
4Other glycan degradation_Homo sapiens_hsa005114.14365626
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.53083579
6Lysosome_Homo sapiens_hsa041423.03932603
7Asthma_Homo sapiens_hsa053103.00113006
8Osteoclast differentiation_Homo sapiens_hsa043802.62297638
9Autoimmune thyroid disease_Homo sapiens_hsa053202.58031206
10Prion diseases_Homo sapiens_hsa050202.27504857
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.24839442
12Pertussis_Homo sapiens_hsa051332.15833401
13Type I diabetes mellitus_Homo sapiens_hsa049402.12085080
14B cell receptor signaling pathway_Homo sapiens_hsa046622.04143409
15Leishmaniasis_Homo sapiens_hsa051402.01642121
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68951534
17Antigen processing and presentation_Homo sapiens_hsa046121.61513742
18Collecting duct acid secretion_Homo sapiens_hsa049661.59893291
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54810897
20Complement and coagulation cascades_Homo sapiens_hsa046101.54214261
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49509461
22Legionellosis_Homo sapiens_hsa051341.45965211
23Ether lipid metabolism_Homo sapiens_hsa005651.42621046
24Viral myocarditis_Homo sapiens_hsa054161.41106498
25Tuberculosis_Homo sapiens_hsa051521.34685126
26Toxoplasmosis_Homo sapiens_hsa051451.29971971
27Chemokine signaling pathway_Homo sapiens_hsa040621.28549586
28Platelet activation_Homo sapiens_hsa046111.27359803
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26918492
30Hematopoietic cell lineage_Homo sapiens_hsa046401.12172848
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12045140
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08600272
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04185294
34Salmonella infection_Homo sapiens_hsa051321.03063657
35Pancreatic cancer_Homo sapiens_hsa052121.02160190
36Systemic lupus erythematosus_Homo sapiens_hsa053221.02020787
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00497363
38Measles_Homo sapiens_hsa051620.96034461
39Vibrio cholerae infection_Homo sapiens_hsa051100.90383926
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.89801369
41Chronic myeloid leukemia_Homo sapiens_hsa052200.89749609
42Nitrogen metabolism_Homo sapiens_hsa009100.87157412
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84179298
44Endocytosis_Homo sapiens_hsa041440.80704603
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.78808040
46Apoptosis_Homo sapiens_hsa042100.78271521
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.77321718
48Arachidonic acid metabolism_Homo sapiens_hsa005900.75032510
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.74938599
50Phagosome_Homo sapiens_hsa041450.74845340
51Rheumatoid arthritis_Homo sapiens_hsa053230.74401541
52T cell receptor signaling pathway_Homo sapiens_hsa046600.73624440
53Influenza A_Homo sapiens_hsa051640.72615425
54Mineral absorption_Homo sapiens_hsa049780.69538382
55PPAR signaling pathway_Homo sapiens_hsa033200.69261099
56Sphingolipid metabolism_Homo sapiens_hsa006000.68275719
57Renin secretion_Homo sapiens_hsa049240.67795689
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67391260
59Colorectal cancer_Homo sapiens_hsa052100.67390194
60Renal cell carcinoma_Homo sapiens_hsa052110.64161612
61Ovarian steroidogenesis_Homo sapiens_hsa049130.63783255
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.63112910
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63036372
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62337011
65Malaria_Homo sapiens_hsa051440.61452604
66Sulfur metabolism_Homo sapiens_hsa009200.60979074
67TNF signaling pathway_Homo sapiens_hsa046680.60375834
68Herpes simplex infection_Homo sapiens_hsa051680.59054861
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.58646757
70Hepatitis B_Homo sapiens_hsa051610.56297392
71MAPK signaling pathway_Homo sapiens_hsa040100.56239709
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55348686
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54906018
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54773647
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.54036736
76Notch signaling pathway_Homo sapiens_hsa043300.52110845
77Galactose metabolism_Homo sapiens_hsa000520.51269065
78Salivary secretion_Homo sapiens_hsa049700.51159317
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.50855458
80Synaptic vesicle cycle_Homo sapiens_hsa047210.50667859
81Shigellosis_Homo sapiens_hsa051310.50131637
82ABC transporters_Homo sapiens_hsa020100.49800123
83Graft-versus-host disease_Homo sapiens_hsa053320.48970671
84Estrogen signaling pathway_Homo sapiens_hsa049150.47773443
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47118697
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.46902791
87Histidine metabolism_Homo sapiens_hsa003400.46016865
88African trypanosomiasis_Homo sapiens_hsa051430.45904610
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44825286
90Rap1 signaling pathway_Homo sapiens_hsa040150.41406205
91Allograft rejection_Homo sapiens_hsa053300.41290839
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40183830
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39974901
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39203343
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39060776
96Adherens junction_Homo sapiens_hsa045200.38940786
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36777496
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36540049
99VEGF signaling pathway_Homo sapiens_hsa043700.35856164
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35538385
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35345925
102cAMP signaling pathway_Homo sapiens_hsa040240.34308691
103Primary immunodeficiency_Homo sapiens_hsa053400.34253195
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33945762
105Olfactory transduction_Homo sapiens_hsa047400.31399669
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31036813
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29695120
108Non-small cell lung cancer_Homo sapiens_hsa052230.29456310
109GnRH signaling pathway_Homo sapiens_hsa049120.28619641
110Ras signaling pathway_Homo sapiens_hsa040140.28379312
111FoxO signaling pathway_Homo sapiens_hsa040680.27868279
112Choline metabolism in cancer_Homo sapiens_hsa052310.27447317
113Amoebiasis_Homo sapiens_hsa051460.27193285
114N-Glycan biosynthesis_Homo sapiens_hsa005100.26781487
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26733677
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26366029
117Pancreatic secretion_Homo sapiens_hsa049720.25890031
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25208165
119Acute myeloid leukemia_Homo sapiens_hsa052210.25054730
120Dorso-ventral axis formation_Homo sapiens_hsa043200.24961738
121Hepatitis C_Homo sapiens_hsa051600.24651435
122Type II diabetes mellitus_Homo sapiens_hsa049300.24572844
123Prolactin signaling pathway_Homo sapiens_hsa049170.22147526
124Gastric acid secretion_Homo sapiens_hsa049710.21387741
125Renin-angiotensin system_Homo sapiens_hsa046140.18591421
126Glutathione metabolism_Homo sapiens_hsa004800.16743848
127HTLV-I infection_Homo sapiens_hsa051660.16549101
128Tryptophan metabolism_Homo sapiens_hsa003800.14739822
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14125300
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13829577
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.13297196
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.12445731
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12387256

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