GPR35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.21082885
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.21082885
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.21082885
4modulation by symbiont of host immune response (GO:0052553)6.21082885
5positive regulation by symbiont of host defense response (GO:0052509)6.21082885
6modulation by symbiont of host defense response (GO:0052031)6.21082885
7sulfation (GO:0051923)5.14956402
8regulation of dendritic cell antigen processing and presentation (GO:0002604)4.97181927
9neutrophil activation involved in immune response (GO:0002283)4.74536129
10response to peptidoglycan (GO:0032494)4.55081782
11flavonoid metabolic process (GO:0009812)4.51579985
12branching involved in labyrinthine layer morphogenesis (GO:0060670)4.40187413
13regulation of interferon-beta biosynthetic process (GO:0045357)4.33729014
14cellular extravasation (GO:0045123)4.31204829
15response to host immune response (GO:0052572)4.30251656
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.30251656
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23302406
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.22642166
19purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.22642166
20positive regulation of fatty acid oxidation (GO:0046321)4.08243096
21negative regulation of mast cell activation (GO:0033004)4.07543018
22positive regulation of fatty acid beta-oxidation (GO:0032000)4.05818337
23immunoglobulin mediated immune response (GO:0016064)4.05176021
24regulation of mast cell degranulation (GO:0043304)4.03952325
25macrophage activation involved in immune response (GO:0002281)3.99534506
26cellular response to ATP (GO:0071318)3.98903187
27regulation of mononuclear cell migration (GO:0071675)3.97888166
28respiratory burst (GO:0045730)3.92141369
29regulation of mast cell activation involved in immune response (GO:0033006)3.86681266
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.85190351
31response to host (GO:0075136)3.85190351
32response to host defenses (GO:0052200)3.85190351
33positive regulation of antigen processing and presentation (GO:0002579)3.84803965
34positive regulation of cellular amide metabolic process (GO:0034250)3.81501654
35microglial cell activation (GO:0001774)3.80083432
36regulation of cholesterol storage (GO:0010885)3.68140579
37indole-containing compound catabolic process (GO:0042436)3.64785117
38indolalkylamine catabolic process (GO:0046218)3.64785117
39tryptophan catabolic process (GO:0006569)3.64785117
40transepithelial transport (GO:0070633)3.64085319
41angiotensin maturation (GO:0002003)3.61570994
42superoxide anion generation (GO:0042554)3.59515148
43positive regulation of mast cell activation involved in immune response (GO:0033008)3.58666101
44positive regulation of mast cell degranulation (GO:0043306)3.58666101
45regulation of antigen processing and presentation (GO:0002577)3.56315951
46regulation of triglyceride catabolic process (GO:0010896)3.55288910
47behavioral response to nicotine (GO:0035095)3.52677515
48regulation of mast cell activation (GO:0033003)3.51163037
49neutrophil activation (GO:0042119)3.50570433
50regulation of B cell receptor signaling pathway (GO:0050855)3.49431119
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49090040
52positive regulation of triglyceride biosynthetic process (GO:0010867)3.48598653
53positive regulation of mast cell activation (GO:0033005)3.47772001
54detection of molecule of bacterial origin (GO:0032490)3.45719701
55positive regulation of monocyte chemotaxis (GO:0090026)3.44311288
56cell proliferation in forebrain (GO:0021846)3.44019525
57regulation of cell proliferation involved in kidney development (GO:1901722)3.43449547
58regulation of monocyte chemotaxis (GO:0090025)3.43356486
59production of molecular mediator involved in inflammatory response (GO:0002532)3.41758771
60sulfate transmembrane transport (GO:1902358)3.41666399
61positive regulation of interferon-alpha production (GO:0032727)3.41321546
62negative regulation of interleukin-12 production (GO:0032695)3.39771948
63positive regulation of type 2 immune response (GO:0002830)3.35622304
64granulocyte activation (GO:0036230)3.32501324
65regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.31094233
66intestinal absorption (GO:0050892)3.29189531
67regulation of interferon-alpha production (GO:0032647)3.28860272
68cellular anion homeostasis (GO:0030002)3.25264134
69macrophage activation (GO:0042116)3.24485120
70lipoxygenase pathway (GO:0019372)3.22798505
71germinal center formation (GO:0002467)3.22425978
72response to muramyl dipeptide (GO:0032495)3.20595974
73leukocyte aggregation (GO:0070486)3.19414380
74positive regulation of cAMP-mediated signaling (GO:0043950)3.18400093
75regulation of RIG-I signaling pathway (GO:0039535)3.17921807
76regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17839873
77detection of other organism (GO:0098543)3.16346511
78negative regulation of systemic arterial blood pressure (GO:0003085)3.13884549
79kynurenine metabolic process (GO:0070189)3.11081087
80dendritic cell chemotaxis (GO:0002407)3.07929842
81indolalkylamine metabolic process (GO:0006586)3.05189286
82tryptophan metabolic process (GO:0006568)3.04504309
83negative regulation of granulocyte differentiation (GO:0030853)3.04398059
84negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.02219200
85dendritic cell migration (GO:0036336)2.99047905
86regulation of leukocyte degranulation (GO:0043300)2.98269712
87eosinophil chemotaxis (GO:0048245)2.97061738
88regulation of activation of Janus kinase activity (GO:0010533)2.96032195
89regulation of fever generation (GO:0031620)2.92393737
90positive regulation of fatty acid transport (GO:2000193)2.91254920
91positive regulation of triglyceride metabolic process (GO:0090208)2.90464140
92positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90196737
93positive regulation of heat generation (GO:0031652)2.89712516
94water-soluble vitamin biosynthetic process (GO:0042364)2.87543294
95regulation of glomerulus development (GO:0090192)2.87509440
96regulation of integrin activation (GO:0033623)2.85784767
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84864502
98NIK/NF-kappaB signaling (GO:0038061)2.83312582
99positive regulation of interleukin-17 production (GO:0032740)2.81102318
100cellular response to exogenous dsRNA (GO:0071360)2.80996941
101L-fucose catabolic process (GO:0042355)2.80942877
102fucose catabolic process (GO:0019317)2.80942877
103L-fucose metabolic process (GO:0042354)2.80942877
104interferon-gamma secretion (GO:0072643)2.79644232
105regulation of platelet aggregation (GO:0090330)2.79182637
106lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78710220
107regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.77995574
108cellular biogenic amine catabolic process (GO:0042402)2.76990428
109amine catabolic process (GO:0009310)2.76990428
110vitamin biosynthetic process (GO:0009110)2.75111929
111myeloid cell activation involved in immune response (GO:0002275)2.75108170
112B cell mediated immunity (GO:0019724)2.74772360
113positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74258993
114positive regulation of icosanoid secretion (GO:0032305)2.73801415
115detection of external biotic stimulus (GO:0098581)2.72591746
116negative regulation of leukocyte migration (GO:0002686)2.71595919
117regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.71342521
118positive regulation of interleukin-12 production (GO:0032735)2.71132838
119negative regulation of fibrinolysis (GO:0051918)2.70237685
120positive regulation of systemic arterial blood pressure (GO:0003084)2.69721835
121positive regulation of NF-kappaB import into nucleus (GO:0042346)2.69417392
122sulfate transport (GO:0008272)2.68883149
123positive regulation of chemokine production (GO:0032722)2.67993319
124regulation of lymphocyte chemotaxis (GO:1901623)2.67884197
125regulation of guanylate cyclase activity (GO:0031282)2.66989889
126lipoprotein transport (GO:0042953)2.66008804
127regulation of interleukin-6 biosynthetic process (GO:0045408)2.65824690
128regulation of macrophage cytokine production (GO:0010935)2.65666142
129lung morphogenesis (GO:0060425)2.65665050
130monocyte chemotaxis (GO:0002548)2.65502735
131neutrophil mediated immunity (GO:0002446)2.64820708
132myeloid dendritic cell activation (GO:0001773)2.63979940
133positive regulation of fatty acid metabolic process (GO:0045923)2.63630122
134G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63575400
135negative regulation of lipid storage (GO:0010888)2.63113167
136fat-soluble vitamin biosynthetic process (GO:0042362)2.62680564
137positive regulation of lymphocyte migration (GO:2000403)2.61831633
138tolerance induction (GO:0002507)2.61049209
139positive regulation of digestive system process (GO:0060456)2.61016839
140eosinophil migration (GO:0072677)2.60801477
141interferon-gamma-mediated signaling pathway (GO:0060333)2.60539325
142positive regulation of lipid catabolic process (GO:0050996)2.59538996
143regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.59043588
144myeloid dendritic cell differentiation (GO:0043011)2.59006245
145detection of bacterium (GO:0016045)2.58734868
146regulation of germinal center formation (GO:0002634)2.58549083
147DNA deamination (GO:0045006)2.56769166
148positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.56636954
149positive regulation of chemokine biosynthetic process (GO:0045080)2.54458585
150regulation of lymphocyte migration (GO:2000401)2.54189731
151neutrophil chemotaxis (GO:0030593)2.54109637
152response to protozoan (GO:0001562)2.53819949
153defense response to protozoan (GO:0042832)2.53769661
154negative regulation of protein tyrosine kinase activity (GO:0061099)2.53758531
155positive regulation of interferon-beta production (GO:0032728)2.53712502
156regulation of interleukin-12 production (GO:0032655)2.53217185
157diacylglycerol metabolic process (GO:0046339)2.52601521
158positive regulation of prostaglandin secretion (GO:0032308)2.52416218
159low-density lipoprotein particle remodeling (GO:0034374)2.49510095
160regulation of triglyceride biosynthetic process (GO:0010866)2.49112520
161NAD biosynthetic process (GO:0009435)2.49009405
162cytidine metabolic process (GO:0046087)2.47609331
163cytidine catabolic process (GO:0006216)2.47609331
164cytidine deamination (GO:0009972)2.47609331
165CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.38553091
166regulation of macrophage derived foam cell differentiation (GO:0010743)2.38202220
167negative regulation of interleukin-1 beta production (GO:0032691)2.36153614
168positive regulation of defense response to virus by host (GO:0002230)2.35943422
169negative regulation of platelet activation (GO:0010544)2.35584356
170regulation of cholesterol homeostasis (GO:2000188)2.34541643
171regulation of digestive system process (GO:0044058)2.34017992
172cellular response to pH (GO:0071467)2.32541242
173regulation of prostaglandin secretion (GO:0032306)2.32492517
174membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.30913928
175plasma lipoprotein particle assembly (GO:0034377)2.30001725
176regulation of phospholipid biosynthetic process (GO:0071071)2.29710195
177regulation of cellular extravasation (GO:0002691)2.29562405
178regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29085684
179regulation of icosanoid secretion (GO:0032303)2.28219617
180indole-containing compound metabolic process (GO:0042430)2.25828400
181regulation of sequestering of triglyceride (GO:0010889)2.25467262
182negative regulation of alpha-beta T cell activation (GO:0046636)2.24271076
183regulation of vitamin metabolic process (GO:0030656)2.24104589
184positive regulation of T-helper 1 type immune response (GO:0002827)2.24083388
185very-low-density lipoprotein particle assembly (GO:0034379)2.23744162
186aromatic amino acid family catabolic process (GO:0009074)2.23187499
187auditory receptor cell differentiation (GO:0042491)2.22594222
188regulation of regulatory T cell differentiation (GO:0045589)2.22486650
189negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.22196947
190estrogen metabolic process (GO:0008210)2.21184061
191kidney morphogenesis (GO:0060993)2.20849122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.14228873
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.48354821
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.74236482
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.79114882
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.44685207
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.27122535
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23883624
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.13076164
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08378629
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98220190
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81043697
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52673510
13EZH2_22144423_ChIP-Seq_EOC_Human2.46400813
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45571385
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40203218
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.39823758
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36495306
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30536354
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27385296
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22465734
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13773215
22GBX2_23144817_ChIP-Seq_PC3_Human2.03631227
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98500017
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97360327
25* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91039668
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89166602
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.79531372
28VDR_24787735_ChIP-Seq_THP-1_Human1.74571256
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71661806
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64092358
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63363568
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62646995
33* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62407106
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61907508
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61265245
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59035509
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58277307
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.55952961
39RUNX_20019798_ChIP-Seq_JUKART_Human1.55184615
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53544337
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.50008650
42* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47568373
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.47331382
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46017979
45* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44142259
46* STAT3_18555785_Chip-Seq_ESCs_Mouse1.43008163
47GATA4_25053715_ChIP-Seq_YYC3_Human1.42828534
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.42793940
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42701628
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42123092
51DROSHA_22980978_ChIP-Seq_HELA_Human1.41227934
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.40209433
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.38849694
54* NMYC_18555785_Chip-Seq_ESCs_Mouse1.38340385
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37249217
56CJUN_26792858_Chip-Seq_BT549_Human1.36583800
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.36398939
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.35545547
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35435840
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34695268
61ZNF274_21170338_ChIP-Seq_K562_Hela1.34522209
62* P53_22387025_ChIP-Seq_ESCs_Mouse1.34449184
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33474984
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31805050
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30420243
66* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30332682
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30037774
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29237887
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29037834
70VDR_24763502_ChIP-Seq_THP-1_Human1.24584435
71SPI1_23547873_ChIP-Seq_NB4_Human1.24043124
72* SOX2_18555785_Chip-Seq_ESCs_Mouse1.22269936
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22159598
74* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22081092
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21666586
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.21176121
77* PU1_27457419_Chip-Seq_LIVER_Mouse1.21002944
78* P300_18555785_Chip-Seq_ESCs_Mouse1.20493808
79* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19770196
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19359657
81* BCL6_27268052_Chip-Seq_Bcells_Human1.18957794
82STAT1_20625510_ChIP-Seq_HELA_Human1.18931211
83SCL_19346495_ChIP-Seq_HPC-7_Human1.18097841
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17908686
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17773965
86* KLF4_18555785_Chip-Seq_ESCs_Mouse1.15913272
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15637143
88* ZFX_18555785_Chip-Seq_ESCs_Mouse1.15544697
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14456345
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13209681
91* PU_27001747_Chip-Seq_BMDM_Mouse1.13143663
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13024549
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.12947694
94* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11678201
95* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11529638
96* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11513782
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11360896
98* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10899324
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09556402
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08973174
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08071182
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.07579816
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07573160
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07268030
105SPI1_23127762_ChIP-Seq_K562_Human1.07220459
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06500491
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06237919
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.05519965
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.04937739
110BCAT_22108803_ChIP-Seq_LS180_Human1.02896422
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02755601
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02241981
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02123279
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01677261
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01584332
116* KDM2B_26808549_Chip-Seq_REH_Human1.01504398
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01286876
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.00701757
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00507360
120IGF1R_20145208_ChIP-Seq_DFB_Human1.00089018
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00018256
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99656549
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99531296
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.99278503
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99113152
126BCOR_27268052_Chip-Seq_Bcells_Human0.98341436
127TAF2_19829295_ChIP-Seq_ESCs_Human0.98293708
128* FOXH1_21741376_ChIP-Seq_ESCs_Human0.97001030
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96290159
130* MYB_26560356_Chip-Seq_TH2_Human0.96265120
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95791335
132VDR_21846776_ChIP-Seq_THP-1_Human0.95342437
133NANOG_20526341_ChIP-Seq_ESCs_Human0.95155788
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.94790330
135* CRX_20693478_ChIP-Seq_RETINA_Mouse0.94779063
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94174818
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94020910
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93675114
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.91881345
140ERA_21632823_ChIP-Seq_H3396_Human0.91855571
141ER_23166858_ChIP-Seq_MCF-7_Human0.91732580
142JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91729050
143GATA3_27048872_Chip-Seq_THYMUS_Human0.91644761
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91409721
145P300_27268052_Chip-Seq_Bcells_Human0.91246675
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90887625
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89798767
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88832461
149* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88586180
150* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88494253
151P300_19829295_ChIP-Seq_ESCs_Human0.88344900
152* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87944539
153RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87895331
154E2F1_20622854_ChIP-Seq_HELA_Human0.87274634
155VDR_22108803_ChIP-Seq_LS180_Human0.87056489
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.86779400
157SMRT_27268052_Chip-Seq_Bcells_Human0.86656406
158GATA6_25053715_ChIP-Seq_YYC3_Human0.86145559
159SMAD4_21799915_ChIP-Seq_A2780_Human0.86024025
160CBX2_27304074_Chip-Seq_ESCs_Mouse0.85589232
161SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85588723
162MYC_19829295_ChIP-Seq_ESCs_Human0.84949663
163* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84245092
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84065090
165YY1_22570637_ChIP-Seq_MALME-3M_Human0.83988877
166* RAC3_21632823_ChIP-Seq_H3396_Human0.83290176
167AHR_22903824_ChIP-Seq_MCF-7_Human0.83027606
168* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82773121
169REST_21632747_ChIP-Seq_MESCs_Mouse0.80839616
170GATA3_26560356_Chip-Seq_TH2_Human0.80621714
171CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80596412
172CTCF_20526341_ChIP-Seq_ESCs_Human0.80455639
173LXR_22292898_ChIP-Seq_THP-1_Human0.80433302
174NCOR_22424771_ChIP-Seq_293T_Human0.80219415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.14133043
2MP0005360_urolithiasis4.20411166
3MP0001835_abnormal_antigen_presentation4.15491792
4MP0003724_increased_susceptibility_to3.55883490
5MP0004510_myositis3.48029705
6MP0002148_abnormal_hypersensitivity_rea3.33057085
7MP0003303_peritoneal_inflammation3.17700346
8MP0003436_decreased_susceptibility_to3.16918222
9MP0002419_abnormal_innate_immunity3.14983960
10MP0001790_abnormal_immune_system2.91685441
11MP0005387_immune_system_phenotype2.91685441
12MP0005000_abnormal_immune_tolerance2.90309640
13MP0005451_abnormal_body_composition2.76002394
14MP0009785_altered_susceptibility_to2.68232223
15MP0006082_CNS_inflammation2.61344544
16MP0005025_abnormal_response_to2.57816709
17MP0005365_abnormal_bile_salt2.53921147
18MP0002452_abnormal_antigen_presenting2.52169287
19MP0001800_abnormal_humoral_immune2.43738312
20MP0003195_calcinosis2.38925518
21MP0005671_abnormal_response_to2.35466717
22MP0002723_abnormal_immune_serum2.28890643
23MP0001986_abnormal_taste_sensitivity2.19215973
24MP0001485_abnormal_pinna_reflex2.18191414
25MP0002405_respiratory_system_inflammati2.18008378
26MP0003172_abnormal_lysosome_physiology2.14936548
27MP0005310_abnormal_salivary_gland2.08849951
28MP0001819_abnormal_immune_cell2.07505226
29MP0002420_abnormal_adaptive_immunity2.05840588
30MP0002876_abnormal_thyroid_physiology2.05471841
31MP0005670_abnormal_white_adipose1.99826187
32MP0000685_abnormal_immune_system1.92095737
33MP0000343_altered_response_to1.90188636
34MP0005085_abnormal_gallbladder_physiolo1.87959419
35MP0001533_abnormal_skeleton_physiology1.86250135
36MP0009333_abnormal_splenocyte_physiolog1.84647043
37MP0001666_abnormal_nutrient_absorption1.82767661
38MP0004019_abnormal_vitamin_homeostasis1.79858468
39MP0009764_decreased_sensitivity_to1.79685444
40MP0002138_abnormal_hepatobiliary_system1.78713270
41MP0001853_heart_inflammation1.76515163
42MP0001845_abnormal_inflammatory_respons1.72573252
43MP0010155_abnormal_intestine_physiology1.72325793
44MP0010329_abnormal_lipoprotein_level1.71742597
45MP0008260_abnormal_autophagy1.67327683
46MP0008872_abnormal_physiological_respon1.63572527
47MP0001851_eye_inflammation1.60781216
48MP0008875_abnormal_xenobiotic_pharmacok1.59419384
49MP0003879_abnormal_hair_cell1.59395833
50MP0002277_abnormal_respiratory_mucosa1.59333117
51MP0005058_abnormal_lysosome_morphology1.58320204
52MP0008004_abnormal_stomach_pH1.56807238
53MP0005464_abnormal_platelet_physiology1.55529052
54MP0002933_joint_inflammation1.46835718
55MP0003828_pulmonary_edema1.44173912
56MP0003646_muscle_fatigue1.42026483
57MP0002132_abnormal_respiratory_system1.40782391
58MP0000716_abnormal_immune_system1.40601115
59MP0005390_skeleton_phenotype1.40350125
60MP0003448_altered_tumor_morphology1.37224818
61MP0003638_abnormal_response/metabolism_1.34048746
62MP0009379_abnormal_foot_pigmentation1.32701122
63MP0002102_abnormal_ear_morphology1.31123522
64MP0004947_skin_inflammation1.30844331
65MP0001765_abnormal_ion_homeostasis1.29271032
66MP0000569_abnormal_digit_pigmentation1.27632290
67MP0003075_altered_response_to1.27418800
68MP0002998_abnormal_bone_remodeling1.23921956
69MP0002398_abnormal_bone_marrow1.22645165
70MP0005646_abnormal_pituitary_gland1.21851959
71MP0003300_gastrointestinal_ulcer1.21621073
72MP0000678_abnormal_parathyroid_gland1.20569639
73MP0003252_abnormal_bile_duct1.19686474
74MP0002736_abnormal_nociception_after1.13947579
75MP0002396_abnormal_hematopoietic_system1.13206826
76MP0000015_abnormal_ear_pigmentation1.12294664
77MP0000689_abnormal_spleen_morphology1.11833588
78MP0003690_abnormal_glial_cell1.11415820
79MP0002653_abnormal_ependyma_morphology1.10287083
80MP0004130_abnormal_muscle_cell1.09539404
81MP0000465_gastrointestinal_hemorrhage1.09043112
82MP0008469_abnormal_protein_level1.08624596
83MP0009765_abnormal_xenobiotic_induced1.07234379
84MP0004782_abnormal_surfactant_physiolog1.06639015
85MP0002837_dystrophic_cardiac_calcinosis1.06288548
86MP0002160_abnormal_reproductive_system1.05616653
87MP0002429_abnormal_blood_cell1.05423803
88MP0005389_reproductive_system_phenotype1.05087309
89MP0000490_abnormal_crypts_of1.03105117
90MP0001764_abnormal_homeostasis1.02820914
91MP0005166_decreased_susceptibility_to1.02348834
92MP0005332_abnormal_amino_acid1.02331665
93MP0001664_abnormal_digestion1.00787100
94MP0005167_abnormal_blood-brain_barrier0.98141606
95MP0005448_abnormal_energy_balance0.97305096
96MP0003950_abnormal_plasma_membrane0.96859798
97MP0005084_abnormal_gallbladder_morpholo0.96544367
98MP0003718_maternal_effect0.96468248
99MP0001663_abnormal_digestive_system0.95956477
100MP0002136_abnormal_kidney_physiology0.94277662
101MP0005636_abnormal_mineral_homeostasis0.93446916
102MP0008438_abnormal_cutaneous_collagen0.92779359
103MP0002722_abnormal_immune_system0.92463045
104MP0001542_abnormal_bone_strength0.91382342
105MP0009384_cardiac_valve_regurgitation0.90154882
106MP0003045_fibrosis0.89938109
107MP0004264_abnormal_extraembryonic_tissu0.89257208
108MP0002735_abnormal_chemical_nociception0.88959761
109MP0002118_abnormal_lipid_homeostasis0.87549365
110MP0005551_abnormal_eye_electrophysiolog0.87274384
111MP0000230_abnormal_systemic_arterial0.87166648
112MP0000858_altered_metastatic_potential0.86357583
113MP0004885_abnormal_endolymph0.85988934
114MP0009643_abnormal_urine_homeostasis0.84847284
115MP0000604_amyloidosis0.83966917
116MP0003011_delayed_dark_adaptation0.82404926
117MP0001873_stomach_inflammation0.82367286
118MP0004742_abnormal_vestibular_system0.80652769
119MP0002971_abnormal_brown_adipose0.79801696
120MP0009697_abnormal_copulation0.79191001
121MP0005164_abnormal_response_to0.79092828
122MP0000049_abnormal_middle_ear0.77177653
123MP0004043_abnormal_pH_regulation0.76919015
124MP0000609_abnormal_liver_physiology0.76727069
125MP0005397_hematopoietic_system_phenotyp0.76592888
126MP0001545_abnormal_hematopoietic_system0.76592888
127MP0003453_abnormal_keratinocyte_physiol0.76541101
128MP0001501_abnormal_sleep_pattern0.76530232
129MP0003806_abnormal_nucleotide_metabolis0.76459817
130MP0009115_abnormal_fat_cell0.75588680
131MP0002006_tumorigenesis0.73801838
132MP0002254_reproductive_system_inflammat0.73563018
133MP0002089_abnormal_postnatal_growth/wei0.73474985
134MP0004134_abnormal_chest_morphology0.73456222
135MP0003136_yellow_coat_color0.73445632
136MP0009840_abnormal_foam_cell0.72878597
137MP0001119_abnormal_female_reproductive0.72820824
138MP0005381_digestive/alimentary_phenotyp0.72340385
139MP0010386_abnormal_urinary_bladder0.72246799
140MP0005174_abnormal_tail_pigmentation0.72234733
141MP0005395_other_phenotype0.72111316
142MP0009278_abnormal_bone_marrow0.70824448
143MP0003183_abnormal_peptide_metabolism0.69431426
144MP0005171_absent_coat_pigmentation0.68568342
145MP0000767_abnormal_smooth_muscle0.67399541
146MP0003866_abnormal_defecation0.67321045
147MP0001188_hyperpigmentation0.67044740
148MP0006292_abnormal_olfactory_placode0.64451104
149MP0000249_abnormal_blood_vessel0.64268480
150MP0003763_abnormal_thymus_physiology0.63425841
151MP0003795_abnormal_bone_structure0.62134383
152MP0002168_other_aberrant_phenotype0.61407952
153MP0005257_abnormal_intraocular_pressure0.60425555
154MP0000579_abnormal_nail_morphology0.59545724

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.71278815
2Recurrent bacterial skin infections (HP:0005406)5.83223608
3Eczematoid dermatitis (HP:0000976)5.37809921
4Retrobulbar optic neuritis (HP:0100654)5.23228369
5Optic neuritis (HP:0100653)5.23228369
6Orchitis (HP:0100796)5.03602235
7Myositis (HP:0100614)4.65023437
8Pendular nystagmus (HP:0012043)4.41379137
9Recurrent gram-negative bacterial infections (HP:0005420)4.23989625
10Systemic lupus erythematosus (HP:0002725)4.23904949
11Abnormality of macrophages (HP:0004311)4.11220103
12Chronic obstructive pulmonary disease (HP:0006510)4.07646544
13Obstructive lung disease (HP:0006536)4.07646544
14Stomatitis (HP:0010280)3.88745307
15Congenital sensorineural hearing impairment (HP:0008527)3.86858863
16Prostate neoplasm (HP:0100787)3.81132734
17Gingivitis (HP:0000230)3.79296883
18Recurrent skin infections (HP:0001581)3.68274957
19Mediastinal lymphadenopathy (HP:0100721)3.63816634
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61345642
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46988817
22Chromsome breakage (HP:0040012)3.39225805
23Abolished electroretinogram (ERG) (HP:0000550)3.29044139
24Elevated erythrocyte sedimentation rate (HP:0003565)3.25303130
25Short 1st metacarpal (HP:0010034)3.16157709
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.16157709
27Abnormality of the 1st metacarpal (HP:0010009)3.14454734
28Recurrent fungal infections (HP:0002841)3.03640046
29Confusion (HP:0001289)3.00580705
30Chronic mucocutaneous candidiasis (HP:0002728)3.00236218
31Recurrent cutaneous fungal infections (HP:0011370)3.00236218
32Keratoconjunctivitis sicca (HP:0001097)2.99651452
33Abnormality of proline metabolism (HP:0010907)2.99001145
34Hydroxyprolinuria (HP:0003080)2.99001145
35Pulmonary infiltrates (HP:0002113)2.95530359
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94610639
37Abnormality of the nasal septum (HP:0000419)2.89786882
38Pustule (HP:0200039)2.86418664
39Agitation (HP:0000713)2.84696336
40Autoimmune thrombocytopenia (HP:0001973)2.82776361
41Severe visual impairment (HP:0001141)2.80319795
42Keratoconjunctivitis (HP:0001096)2.76713474
43Short phalanx of the thumb (HP:0009660)2.76615056
44Vasculitis (HP:0002633)2.75969635
45Abnormality of glycolipid metabolism (HP:0010969)2.75443326
46Abnormality of liposaccharide metabolism (HP:0010968)2.75443326
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.75443326
48Abnormal hair whorl (HP:0010721)2.67558075
49Short femoral neck (HP:0100864)2.66681545
50Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.64315445
51Periodontitis (HP:0000704)2.60722207
52Vacuolated lymphocytes (HP:0001922)2.60442343
53Recurrent pneumonia (HP:0006532)2.60202333
54Abnormality of the prostate (HP:0008775)2.58669211
55Decreased circulating renin level (HP:0003351)2.56244860
56Genetic anticipation (HP:0003743)2.54505833
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51713459
58Meningitis (HP:0001287)2.50903068
59Spondylolisthesis (HP:0003302)2.49563179
60Pigmentary retinal degeneration (HP:0001146)2.47610449
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44409956
62Abnormal rod and cone electroretinograms (HP:0008323)2.42852954
63Porencephaly (HP:0002132)2.38585632
64Arterial thrombosis (HP:0004420)2.35867261
65Spontaneous hematomas (HP:0007420)2.34731847
66Xerostomia (HP:0000217)2.31983218
67Bone cyst (HP:0012062)2.31918636
68Pancreatic cysts (HP:0001737)2.31412854
69Hematochezia (HP:0002573)2.30434694
70Thick nail (HP:0001805)2.30060255
71Glomerulopathy (HP:0100820)2.29082562
72Abnormality of polysaccharide metabolism (HP:0011012)2.28724645
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28724645
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28724645
75Hemoptysis (HP:0002105)2.28608278
76True hermaphroditism (HP:0010459)2.26931482
77Keratoconus (HP:0000563)2.26199371
78Increased corneal curvature (HP:0100692)2.26199371
79Leukocytosis (HP:0001974)2.23125567
80Decreased central vision (HP:0007663)2.22306632
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.21642638
82Malnutrition (HP:0004395)2.21429287
83Pulmonary fibrosis (HP:0002206)2.20787216
84Mucopolysacchariduria (HP:0008155)2.19908367
85Urinary glycosaminoglycan excretion (HP:0003541)2.19908367
86Submucous cleft hard palate (HP:0000176)2.16783595
87Congenital stationary night blindness (HP:0007642)2.16631989
88Cheilitis (HP:0100825)2.16048519
89Pancreatic fibrosis (HP:0100732)2.15400116
90Abnormality of vitamin B metabolism (HP:0004340)2.15235130
91Methylmalonic aciduria (HP:0012120)2.13715101
92Gastrointestinal infarctions (HP:0005244)2.13218736
93Basal ganglia calcification (HP:0002135)2.12865382
94Axonal loss (HP:0003447)2.12795543
95Glomerulonephritis (HP:0000099)2.10159847
96Disinhibition (HP:0000734)2.09980110
97Encephalitis (HP:0002383)2.08963297
98Metabolic alkalosis (HP:0200114)2.07719412
99Abnormality of DNA repair (HP:0003254)2.07585941
100Xanthomatosis (HP:0000991)2.07486243
101Hypergonadotropic hypogonadism (HP:0000815)2.04819296
102Parakeratosis (HP:0001036)2.04626183
103Poor head control (HP:0002421)2.04045174
104Decreased subcutaneous fat (HP:0001002)2.03856267
105Aplasia/hypoplasia of the femur (HP:0005613)2.02790557
106Recurrent lower respiratory tract infections (HP:0002783)2.00233664
107Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.00008426
108Progressive cerebellar ataxia (HP:0002073)1.98033102
109Loss of speech (HP:0002371)1.96829533
110Metaphyseal irregularity (HP:0003025)1.96757160
111Recurrent viral infections (HP:0004429)1.95925612
112IgG deficiency (HP:0004315)1.95876927
113Cellulitis (HP:0100658)1.95328520
114Anorexia (HP:0002039)1.95002950
115Clumsiness (HP:0002312)1.94291562
116Ventricular fibrillation (HP:0001663)1.94270984
117Clubbing of toes (HP:0100760)1.93592901
118Asplenia (HP:0001746)1.93087461
119Chorioretinal atrophy (HP:0000533)1.92545030
120Peritonitis (HP:0002586)1.92064088
121Hypoplasia of the fovea (HP:0007750)1.91746843
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.91746843
123Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.91555595
124Abnormality of the proximal phalanges of the hand (HP:0009834)1.90765231
125Inflammation of the large intestine (HP:0002037)1.89759779
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.87959907
127Gingival bleeding (HP:0000225)1.86108439
128Dysostosis multiplex (HP:0000943)1.85851965
129Abnormality of the costochondral junction (HP:0000919)1.85407016
1303-Methylglutaconic aciduria (HP:0003535)1.84969284
131Late onset (HP:0003584)1.84629888
132Interstitial pulmonary disease (HP:0006530)1.84114531
133Cystic liver disease (HP:0006706)1.83261912
134Petechiae (HP:0000967)1.82990855
135Abnormality of male internal genitalia (HP:0000022)1.82573615
136Chronic diarrhea (HP:0002028)1.82377416
137Furrowed tongue (HP:0000221)1.82060744
138Urticaria (HP:0001025)1.81966496
139Acute myeloid leukemia (HP:0004808)1.81337443
140Conjunctival hamartoma (HP:0100780)1.80796392
141Increased neuronal autofluorescent lipopigment (HP:0002074)1.80491945
142Segmental peripheral demyelination/remyelination (HP:0003481)1.79920235
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.79516882
144Abnormality of binocular vision (HP:0011514)1.79345346
145Diplopia (HP:0000651)1.79345346
146Abnormality of vitamin metabolism (HP:0100508)1.79163747
147Alveolar cell carcinoma (HP:0006519)1.76006744
148Complement deficiency (HP:0004431)1.75258603
149Short hallux (HP:0010109)1.74343212
150Abnormality of the pericardium (HP:0001697)1.73499664
151Flat capital femoral epiphysis (HP:0003370)1.73299955
152Abnormality of the endocardium (HP:0004306)1.72902069
153Increased cerebral lipofuscin (HP:0011813)1.72009887
154Methylmalonic acidemia (HP:0002912)1.72002224
155Flared iliac wings (HP:0002869)1.70326651
156Osteomyelitis (HP:0002754)1.69228232
157Myocardial infarction (HP:0001658)1.68847095
158Agnosia (HP:0010524)1.68545957
159Abnormality of B cell number (HP:0010975)1.68296472
160Widely patent fontanelles and sutures (HP:0004492)1.67907419
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67341955
162Abnormality of the renal cortex (HP:0011035)1.66570242
163Posterior subcapsular cataract (HP:0007787)1.66300489
164Aseptic necrosis (HP:0010885)1.65448744
165Arthropathy (HP:0003040)1.65350168
166Duplicated collecting system (HP:0000081)1.63308973
167Progressive visual loss (HP:0000529)1.63141587
168Thyroiditis (HP:0100646)1.61379099
169Keratitis (HP:0000491)1.59098405
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.58974872
171Eosinophilia (HP:0001880)1.58918626
172Premature loss of primary teeth (HP:0006323)1.57704157
173Hepatosplenomegaly (HP:0001433)1.57312409
174Abnormality of the fovea (HP:0000493)1.56650916
175Abnormality of the pleura (HP:0002103)1.56034797
176Adrenal hypoplasia (HP:0000835)1.55559782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.46068472
2ACVR1B4.02700696
3MAP3K143.40372181
4IRAK33.17579178
5IRAK43.10236796
6WNK42.47742898
7TYK22.32164234
8MAP4K12.22294047
9TAOK32.16357448
10TXK2.12659779
11PRKD22.12455554
12IKBKB2.10496897
13STK392.09511955
14EPHA31.91420515
15IKBKE1.91338554
16BMPR1B1.89391613
17KIT1.86776690
18MAP3K131.82811526
19TBK11.82658515
20RIPK41.78598488
21BMPR21.75641217
22MUSK1.74269251
23EPHB11.74058157
24NEK91.72206829
25MAP2K61.71799200
26PINK11.69074080
27ZAK1.66706111
28CLK11.65077890
29BRAF1.61687714
30PIM21.60893595
31PLK41.57787507
32ERN11.57419409
33CSK1.53235634
34MAP3K111.52031621
35GRK61.51524995
36IRAK11.44391373
37JAK31.44024793
38CHUK1.42913824
39DDR21.42583910
40MST1R1.40347705
41EPHA21.38201575
42ERBB41.37905997
43MAP3K61.35914688
44NUAK11.35367719
45SIK31.33535267
46DAPK21.31724254
47TRPM71.27530600
48JAK11.25267471
49PBK1.24276901
50TAOK11.23550181
51TEC1.22040283
52FGR1.19062521
53STK38L1.18098991
54MAP4K21.17970155
55SIK11.17061760
56EIF2AK21.14884334
57OXSR11.12579395
58ABL21.11268928
59PRKG21.06496818
60PIM11.05783380
61ARAF1.05204982
62TNK21.05128117
63CDK81.04246656
64MAP2K21.01220838
65CDC42BPA0.99816524
66LYN0.98631604
67STK30.98067738
68PIK3CA0.97809581
69CAMKK20.96299184
70HCK0.95680132
71NLK0.92327391
72CSF1R0.91977122
73CASK0.90413176
74IRAK20.88505381
75MATK0.87214024
76PRKCI0.87116678
77ERBB20.86544807
78FGFR40.85738892
79TYRO30.85557888
80MAP3K120.84194166
81STK100.83738179
82FES0.83553167
83PRPF4B0.83478778
84EPHB20.82615995
85NEK60.81807232
86ADRBK20.80846301
87GRK70.80839530
88MAPK110.80669813
89RPS6KA60.80410131
90LMTK20.79662802
91SYK0.79558038
92BTK0.78286207
93ZAP700.77452540
94FRK0.75044238
95LCK0.74793643
96CDK90.74129635
97DYRK20.73084646
98YES10.72562013
99SIK20.72402135
100LATS10.72104623
101TGFBR20.69076120
102MST40.68793024
103MAPKAPK50.67814363
104TTK0.67670011
105STK240.65449779
106PKN10.64623727
107INSRR0.64395086
108ABL10.63132543
109NME20.62489389
110TNIK0.62326127
111CAMK1D0.62226764
112SGK20.60923583
113RPS6KC10.60144224
114RPS6KL10.60144224
115RPS6KA40.59546927
116PTK60.58457873
117MAP3K10.57628473
118MAPKAPK30.55857065
119PRKCZ0.55196509
120JAK20.54637693
121TLK10.54623383
122MARK30.54431290
123PDPK10.53563795
124MELK0.53557280
125ITK0.53337156
126RIPK10.52654678
127CSNK1A10.50622654
128TAOK20.50307566
129PDK10.50251413
130WNK30.47604446
131MOS0.46936005
132CDK30.46700000
133PRKCD0.46680186
134SGK2230.46353556
135SGK4940.46353556
136RPS6KA50.44260357
137HIPK20.44152932
138RPS6KA20.43140181
139GRK10.42097848
140AKT30.41009456
141FGFR30.40378986
142PRKCG0.40215362
143PRKAA20.38296055
144PRKACG0.37763900
145MAPK130.34993564
146MKNK20.33904587
147MAP3K30.33858871
148PRKCQ0.33217157
149PIK3CG0.31658595
150PRKCE0.31300407
151MAPKAPK20.31073491

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.96360341
2Staphylococcus aureus infection_Homo sapiens_hsa051502.71222493
3Sulfur metabolism_Homo sapiens_hsa009202.67715338
4Vitamin digestion and absorption_Homo sapiens_hsa049772.59715516
5Renin-angiotensin system_Homo sapiens_hsa046142.59671772
6Fat digestion and absorption_Homo sapiens_hsa049752.58842385
7Malaria_Homo sapiens_hsa051442.51046106
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.43777413
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.32437475
10Rheumatoid arthritis_Homo sapiens_hsa053232.30555453
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29163482
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.22896425
13Other glycan degradation_Homo sapiens_hsa005112.21726991
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12180842
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03144221
16Graft-versus-host disease_Homo sapiens_hsa053322.00541890
17Cyanoamino acid metabolism_Homo sapiens_hsa004602.00297122
18Legionellosis_Homo sapiens_hsa051341.96167117
19Osteoclast differentiation_Homo sapiens_hsa043801.91907075
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90790700
21Tuberculosis_Homo sapiens_hsa051521.89630203
22Hematopoietic cell lineage_Homo sapiens_hsa046401.89415474
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78111075
24Pertussis_Homo sapiens_hsa051331.77402690
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.73917013
26Chemical carcinogenesis_Homo sapiens_hsa052041.73089649
27Allograft rejection_Homo sapiens_hsa053301.70734276
28TNF signaling pathway_Homo sapiens_hsa046681.67258665
29Tryptophan metabolism_Homo sapiens_hsa003801.66769511
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.65561411
31Measles_Homo sapiens_hsa051621.56099777
32Glycerolipid metabolism_Homo sapiens_hsa005611.53320856
33Lysosome_Homo sapiens_hsa041421.52646406
34Phagosome_Homo sapiens_hsa041451.51402308
35Histidine metabolism_Homo sapiens_hsa003401.51092598
36Chemokine signaling pathway_Homo sapiens_hsa040621.48952788
37Salmonella infection_Homo sapiens_hsa051321.47635582
38Asthma_Homo sapiens_hsa053101.47462550
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41293160
40PPAR signaling pathway_Homo sapiens_hsa033201.40891574
41Retinol metabolism_Homo sapiens_hsa008301.37282295
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.34254189
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33813554
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.32931954
45Arachidonic acid metabolism_Homo sapiens_hsa005901.31660752
46Influenza A_Homo sapiens_hsa051641.28584802
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27837925
48Toxoplasmosis_Homo sapiens_hsa051451.27540679
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26478070
50Herpes simplex infection_Homo sapiens_hsa051681.25101352
51Starch and sucrose metabolism_Homo sapiens_hsa005001.24579221
52Autoimmune thyroid disease_Homo sapiens_hsa053201.24239717
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23359448
54Caffeine metabolism_Homo sapiens_hsa002321.23289089
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22515181
56Sphingolipid metabolism_Homo sapiens_hsa006001.21156749
57Shigellosis_Homo sapiens_hsa051311.20358422
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18584618
59Ether lipid metabolism_Homo sapiens_hsa005651.14307005
60Nitrogen metabolism_Homo sapiens_hsa009101.12846547
61Apoptosis_Homo sapiens_hsa042101.10202007
62B cell receptor signaling pathway_Homo sapiens_hsa046621.10076970
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09157421
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08989253
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08944560
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00942155
67Pancreatic cancer_Homo sapiens_hsa052121.00067289
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99731943
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98669097
70Hepatitis B_Homo sapiens_hsa051610.98005638
71African trypanosomiasis_Homo sapiens_hsa051430.96211763
72Ovarian steroidogenesis_Homo sapiens_hsa049130.89976118
73Homologous recombination_Homo sapiens_hsa034400.89942338
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86385792
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86038550
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.83971433
77Fatty acid biosynthesis_Homo sapiens_hsa000610.83579127
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83354301
79Fanconi anemia pathway_Homo sapiens_hsa034600.82819935
80Mineral absorption_Homo sapiens_hsa049780.82565254
81Amoebiasis_Homo sapiens_hsa051460.82422110
82Linoleic acid metabolism_Homo sapiens_hsa005910.81418177
83Systemic lupus erythematosus_Homo sapiens_hsa053220.81244851
84Steroid biosynthesis_Homo sapiens_hsa001000.80096677
85ABC transporters_Homo sapiens_hsa020100.79558954
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79025409
87Galactose metabolism_Homo sapiens_hsa000520.77527028
88Basal transcription factors_Homo sapiens_hsa030220.77505806
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76862104
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.75217241
91Hepatitis C_Homo sapiens_hsa051600.74295721
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74241757
93Bile secretion_Homo sapiens_hsa049760.73670409
94Primary immunodeficiency_Homo sapiens_hsa053400.73576723
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72865319
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72645301
97Phototransduction_Homo sapiens_hsa047440.72259608
98Sulfur relay system_Homo sapiens_hsa041220.71059017
99Collecting duct acid secretion_Homo sapiens_hsa049660.70360570
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66243665
101Type I diabetes mellitus_Homo sapiens_hsa049400.65249091
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63386733
103Fatty acid degradation_Homo sapiens_hsa000710.63305177
104Antigen processing and presentation_Homo sapiens_hsa046120.63147911
105p53 signaling pathway_Homo sapiens_hsa041150.63101764
106Viral myocarditis_Homo sapiens_hsa054160.62002588
107Epstein-Barr virus infection_Homo sapiens_hsa051690.61918204
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.61513284
109Prolactin signaling pathway_Homo sapiens_hsa049170.60991668
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60706347
111Acute myeloid leukemia_Homo sapiens_hsa052210.60630935
112Protein digestion and absorption_Homo sapiens_hsa049740.58990606
113T cell receptor signaling pathway_Homo sapiens_hsa046600.57597358
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57389815
115Chronic myeloid leukemia_Homo sapiens_hsa052200.56995680
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56301288
117Vitamin B6 metabolism_Homo sapiens_hsa007500.56107832
118Insulin resistance_Homo sapiens_hsa049310.54140567
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51275586
120Complement and coagulation cascades_Homo sapiens_hsa046100.50513705
121TGF-beta signaling pathway_Homo sapiens_hsa043500.50408558
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.49923596
123Peroxisome_Homo sapiens_hsa041460.46601360
124Renin secretion_Homo sapiens_hsa049240.45448876
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44114831
126Insulin secretion_Homo sapiens_hsa049110.44106425
127Melanoma_Homo sapiens_hsa052180.43660643
128Non-homologous end-joining_Homo sapiens_hsa034500.43475941
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.42001310
130Dorso-ventral axis formation_Homo sapiens_hsa043200.41831482
131Platelet activation_Homo sapiens_hsa046110.41437402
132MAPK signaling pathway_Homo sapiens_hsa040100.40965730
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40319488
134Cell cycle_Homo sapiens_hsa041100.40270721
135* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39824171
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38203883
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.37454914
138MicroRNAs in cancer_Homo sapiens_hsa052060.37410188
139Selenocompound metabolism_Homo sapiens_hsa004500.37221128
140Nicotine addiction_Homo sapiens_hsa050330.36354045
141Renal cell carcinoma_Homo sapiens_hsa052110.36294830
142Small cell lung cancer_Homo sapiens_hsa052220.35153600
143Type II diabetes mellitus_Homo sapiens_hsa049300.34834398
144Inositol phosphate metabolism_Homo sapiens_hsa005620.34443241
145Ras signaling pathway_Homo sapiens_hsa040140.33829061
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32620629
147Serotonergic synapse_Homo sapiens_hsa047260.32451393
148HTLV-I infection_Homo sapiens_hsa051660.32372296
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30366689
150Taste transduction_Homo sapiens_hsa047420.26162704

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