GPR39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)8.38859886
2regulation of female gonad development (GO:2000194)6.45334776
3oocyte development (GO:0048599)6.03445942
4multicellular organism reproduction (GO:0032504)5.89040325
5citrulline biosynthetic process (GO:0019240)5.83108779
6protein kinase C signaling (GO:0070528)5.55061764
7hemidesmosome assembly (GO:0031581)5.45139823
8COPI coating of Golgi vesicle (GO:0048205)4.50231830
9Golgi transport vesicle coating (GO:0048200)4.50231830
10citrulline metabolic process (GO:0000052)4.35956074
11desmosome organization (GO:0002934)4.31085182
12negative regulation of reproductive process (GO:2000242)4.28473008
13positive regulation of humoral immune response (GO:0002922)4.20295467
14reproduction (GO:0000003)4.11440886
15binding of sperm to zona pellucida (GO:0007339)4.10653905
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.10607426
17L-phenylalanine catabolic process (GO:0006559)4.10607426
18mitotic chromosome condensation (GO:0007076)4.02727078
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.00881232
20cell adhesion mediated by integrin (GO:0033627)3.93148878
21regulation of DNA methylation (GO:0044030)3.91601380
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.80971290
23L-phenylalanine metabolic process (GO:0006558)3.80971290
24regulation of fibrinolysis (GO:0051917)3.78487003
25negative regulation of fibrinolysis (GO:0051918)3.69090536
26meiotic cell cycle (GO:0051321)3.65649270
27high-density lipoprotein particle remodeling (GO:0034375)3.63557514
28epithelial cell-cell adhesion (GO:0090136)3.62375485
29intestinal cholesterol absorption (GO:0030299)3.56617202
30reverse cholesterol transport (GO:0043691)3.47590271
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42731338
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.42639063
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.36941059
34piRNA metabolic process (GO:0034587)3.31531075
35aromatic amino acid family catabolic process (GO:0009074)3.28044907
36cysteine metabolic process (GO:0006534)3.22201590
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.21085921
38neuron recognition (GO:0008038)3.19436921
39intestinal absorption (GO:0050892)3.18587369
40daunorubicin metabolic process (GO:0044597)3.17930334
41polyketide metabolic process (GO:0030638)3.17930334
42doxorubicin metabolic process (GO:0044598)3.17930334
43female gamete generation (GO:0007292)3.09898182
44regulation of cholesterol esterification (GO:0010872)3.09859840
45neuron remodeling (GO:0016322)3.09446964
46cholesterol efflux (GO:0033344)3.07482913
47regulation of triglyceride catabolic process (GO:0010896)3.04640264
48positive regulation of lipoprotein lipase activity (GO:0051006)3.01923700
49positive regulation of triglyceride lipase activity (GO:0061365)3.01923700
50bile acid biosynthetic process (GO:0006699)3.00127668
51neuron cell-cell adhesion (GO:0007158)2.99828719
52protein carboxylation (GO:0018214)2.98272177
53peptidyl-glutamic acid carboxylation (GO:0017187)2.98272177
54membrane raft organization (GO:0031579)2.97246647
55cellular ketone body metabolic process (GO:0046950)2.96809577
56cell-substrate junction assembly (GO:0007044)2.95471553
57sulfur amino acid catabolic process (GO:0000098)2.94595406
58protein-lipid complex remodeling (GO:0034368)2.94530385
59macromolecular complex remodeling (GO:0034367)2.94530385
60plasma lipoprotein particle remodeling (GO:0034369)2.94530385
61opsonization (GO:0008228)2.93256932
62activation of Rac GTPase activity (GO:0032863)2.92369630
63triglyceride homeostasis (GO:0070328)2.91638531
64acylglycerol homeostasis (GO:0055090)2.91638531
65epoxygenase P450 pathway (GO:0019373)2.89805491
66fibrinolysis (GO:0042730)2.89208887
67axonal fasciculation (GO:0007413)2.89099692
68protein maturation by protein folding (GO:0022417)2.88332815
69plasma lipoprotein particle clearance (GO:0034381)2.86439315
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.86004681
71regulation of water loss via skin (GO:0033561)2.85519700
72coenzyme catabolic process (GO:0009109)2.85517863
73flavonoid metabolic process (GO:0009812)2.85360195
74vocalization behavior (GO:0071625)2.84842905
75single fertilization (GO:0007338)2.84748302
76urea cycle (GO:0000050)2.84550234
77urea metabolic process (GO:0019627)2.84550234
78skin morphogenesis (GO:0043589)2.84489625
79regulation of steroid hormone biosynthetic process (GO:0090030)2.81304617
80regulation of spindle organization (GO:0090224)2.81127084
81regulation of protein activation cascade (GO:2000257)2.80833502
82maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78108822
83aminoglycoside antibiotic metabolic process (GO:0030647)2.77900708
84regulation of phospholipid biosynthetic process (GO:0071071)2.77006262
85fertilization (GO:0009566)2.76974077
86actin filament depolymerization (GO:0030042)2.76850738
87sperm-egg recognition (GO:0035036)2.76698032
88DNA methylation involved in gamete generation (GO:0043046)2.76055507
89uronic acid metabolic process (GO:0006063)2.74440640
90glucuronate metabolic process (GO:0019585)2.74440640
91protein retention in ER lumen (GO:0006621)2.73751059
92glutamate receptor signaling pathway (GO:0007215)2.73636714
93drug catabolic process (GO:0042737)2.73282159
94phospholipid efflux (GO:0033700)2.72633571
95positive regulation of reproductive process (GO:2000243)2.72152369
96regulation of bile acid biosynthetic process (GO:0070857)2.71948628
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.70795164
98kynurenine metabolic process (GO:0070189)2.70737018
99cellular glucuronidation (GO:0052695)2.67978570
100fatty acid elongation (GO:0030497)2.66995870
101negative regulation of cholesterol transport (GO:0032375)2.66823243
102negative regulation of sterol transport (GO:0032372)2.66823243
103bile acid and bile salt transport (GO:0015721)2.65633198
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.64952642
105bile acid metabolic process (GO:0008206)2.63784196
106regulation of steroid hormone secretion (GO:2000831)2.62584565
107negative regulation of lipase activity (GO:0060192)2.61828113
108nitrogen cycle metabolic process (GO:0071941)2.61704105
109complement activation, alternative pathway (GO:0006957)2.61040482
110gap junction assembly (GO:0016264)2.60856071
111drug transmembrane transport (GO:0006855)2.60739883
112embryo implantation (GO:0007566)2.60579718
113establishment of skin barrier (GO:0061436)2.58981214
114regulation of complement activation (GO:0030449)2.58404167
115positive regulation of actin filament depolymerization (GO:0030836)2.58004352
116positive regulation of DNA-dependent DNA replication (GO:2000105)2.57941633
117tryptophan catabolic process (GO:0006569)2.57354868
118indole-containing compound catabolic process (GO:0042436)2.57354868
119indolalkylamine catabolic process (GO:0046218)2.57354868
120glyoxylate metabolic process (GO:0046487)2.57319508
121regulation of transforming growth factor beta2 production (GO:0032909)2.56150861
122cholesterol homeostasis (GO:0042632)2.55356183
123heme transport (GO:0015886)2.55308926
124glutamate metabolic process (GO:0006536)2.54883883
125mitotic metaphase plate congression (GO:0007080)2.53459898
126sterol homeostasis (GO:0055092)2.53388360
127hypotonic response (GO:0006971)2.53113661
128ketone body metabolic process (GO:1902224)2.51686334
129iron coordination entity transport (GO:1901678)2.51459675
130mesodermal cell differentiation (GO:0048333)2.51435190
131lipoprotein metabolic process (GO:0042157)2.51298014
132cytoskeletal anchoring at plasma membrane (GO:0007016)2.50992508
133alpha-linolenic acid metabolic process (GO:0036109)2.49942840
134presynaptic membrane assembly (GO:0097105)2.48906844
135negative regulation of keratinocyte proliferation (GO:0010839)2.47479923
136regulation of plasminogen activation (GO:0010755)2.47429200
137inner ear receptor cell development (GO:0060119)2.47388002
138negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.47326064
139aldehyde catabolic process (GO:0046185)2.46776298
140homocysteine metabolic process (GO:0050667)2.46202753
141paraxial mesoderm development (GO:0048339)2.45970300
142negative regulation of protein activation cascade (GO:2000258)2.44825166
143cell-cell junction maintenance (GO:0045217)2.43872904
144protein localization to synapse (GO:0035418)2.43847852
145nucleotide-sugar biosynthetic process (GO:0009226)2.43055815
146regulation of meiosis I (GO:0060631)2.41759076
147tyrosine metabolic process (GO:0006570)2.40251752
148plasma lipoprotein particle assembly (GO:0034377)2.40083141
149protein localization to chromosome, centromeric region (GO:0071459)2.39688025
150positive regulation of hormone biosynthetic process (GO:0046886)2.39056727
151pyrimidine-containing compound transmembrane transport (GO:0072531)2.38430660
152negative regulation of hormone metabolic process (GO:0032351)2.38143449
153cellular modified amino acid catabolic process (GO:0042219)2.38047728
154regulation of metalloenzyme activity (GO:0048552)2.37738132
155regulation of reproductive process (GO:2000241)2.37593646
156positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.36580379
157nucleobase catabolic process (GO:0046113)2.35585667
158dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35061383
159very-low-density lipoprotein particle assembly (GO:0034379)2.34841672
160positive regulation of hormone metabolic process (GO:0032352)2.34571953
161glutathione derivative metabolic process (GO:1901685)2.32847270
162glutathione derivative biosynthetic process (GO:1901687)2.32847270
163tryptophan metabolic process (GO:0006568)2.32102078
164retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.31890173
165multicellular organismal water homeostasis (GO:0050891)2.31395124
166oxidative demethylation (GO:0070989)2.31175380
167regulation of glutamate secretion (GO:0014048)2.30146610
168substrate-dependent cell migration (GO:0006929)2.29503326
169protein-lipid complex assembly (GO:0065005)2.29228411
170protein targeting to Golgi (GO:0000042)2.28900735
171regulation of cardioblast differentiation (GO:0051890)2.28313520
172establishment of chromosome localization (GO:0051303)2.28058247
173positive regulation of gastrulation (GO:2000543)2.27984662
174regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.27864501
175type B pancreatic cell proliferation (GO:0044342)2.27434118
176very long-chain fatty acid metabolic process (GO:0000038)2.27125979
177regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.26944589
178branching involved in mammary gland duct morphogenesis (GO:0060444)2.26868915
179aromatic amino acid family metabolic process (GO:0009072)2.25699819
180cholesterol transport (GO:0030301)2.25676211
181sterol transport (GO:0015918)2.25676211
182phenylpropanoid metabolic process (GO:0009698)2.25610198
183positive regulation of Cdc42 GTPase activity (GO:0043089)2.25382554
184positive regulation of fatty acid biosynthetic process (GO:0045723)2.24645683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.18168312
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.16921523
3EZH2_22144423_ChIP-Seq_EOC_Human3.76000354
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.41914210
5GBX2_23144817_ChIP-Seq_PC3_Human3.27695584
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.04868113
7AR_21909140_ChIP-Seq_LNCAP_Human2.76661775
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.57910583
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57438092
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.47370981
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.46589937
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30305907
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.28057892
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.27916054
15* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.24267301
16* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.24267301
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20629886
18* LXR_22158963_ChIP-Seq_LIVER_Mouse2.16934461
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15550839
20TAF15_26573619_Chip-Seq_HEK293_Human2.15013862
21ZNF263_19887448_ChIP-Seq_K562_Human2.14315621
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.08255508
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07891732
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06911355
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06657040
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96248940
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94450209
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.93333283
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.92814437
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91685524
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89454957
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89454957
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89385977
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86526246
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83714476
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82716199
37GATA6_25053715_ChIP-Seq_YYC3_Human1.82050918
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80665566
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.80460778
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79228741
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.76602087
42RACK7_27058665_Chip-Seq_MCF-7_Human1.76430334
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73602118
44ATF3_27146783_Chip-Seq_COLON_Human1.70239048
45* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64272056
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62223815
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62176566
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.61165429
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.59575180
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59545879
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59101746
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59001043
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58424860
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57403112
55TP53_18474530_ChIP-ChIP_U2OS_Human1.57374658
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.55467645
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54446164
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53594151
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53161207
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52409287
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52144304
62ZNF274_21170338_ChIP-Seq_K562_Hela1.51533193
63AR_21572438_ChIP-Seq_LNCaP_Human1.50895844
64P300_19829295_ChIP-Seq_ESCs_Human1.50344984
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49661905
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49661905
67* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48952550
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47835711
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46763120
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44647026
71* SMAD4_21799915_ChIP-Seq_A2780_Human1.44086097
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43631406
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41936699
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.41906075
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40223677
76* GATA3_24758297_ChIP-Seq_MCF-7_Human1.40150368
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38387829
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37646427
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37343446
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37067453
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35433917
82GATA4_25053715_ChIP-Seq_YYC3_Human1.34857479
83FUS_26573619_Chip-Seq_HEK293_Human1.34259168
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34118284
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33478327
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32614844
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32334048
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30529765
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29601381
90DROSHA_22980978_ChIP-Seq_HELA_Human1.28476116
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.28195744
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27054985
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26617326
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.25804983
95* TP53_16413492_ChIP-PET_HCT116_Human1.25726203
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25691500
97E2F7_22180533_ChIP-Seq_HELA_Human1.25561306
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25133304
99BCAT_22108803_ChIP-Seq_LS180_Human1.25000912
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23341124
101REST_21632747_ChIP-Seq_MESCs_Mouse1.22003475
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21729268
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20850756
104VDR_22108803_ChIP-Seq_LS180_Human1.19820553
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19171886
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17929327
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16339484
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15694172
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15139667
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13445467
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12842639
112AR_25329375_ChIP-Seq_VCAP_Human1.10790421
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10029039
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08849029
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.08273892
116* EP300_21415370_ChIP-Seq_HL-1_Mouse1.08128903
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.07834657
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06497434
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06100898
120AHR_22903824_ChIP-Seq_MCF-7_Human1.04198690
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.04048886
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03967291
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03216676
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03180529
125ER_23166858_ChIP-Seq_MCF-7_Human1.02978898
126KLF5_25053715_ChIP-Seq_YYC3_Human1.02933486
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02407514
128* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02331905
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02266253
130UBF1/2_26484160_Chip-Seq_HMECs_Human1.02046687
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01493812
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01444285
133RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01253683
134CLOCK_20551151_ChIP-Seq_293T_Human1.01242842
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01214411
136SOX2_20726797_ChIP-Seq_SW620_Human1.00310745
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00068063
138* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99101133
139* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98371460
140* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98367650
141STAT3_23295773_ChIP-Seq_U87_Human0.98357881
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.98181476
143PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98063264
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96034804
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95794167
146ESR1_20079471_ChIP-ChIP_T-47D_Human0.95357145
147ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94490256
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94237404
149* CDX2_20551321_ChIP-Seq_CACO-2_Human0.93581156
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.93278941
151SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92922514
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92784908
153CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92186448
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91842986
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91744664
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91506678
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91458678
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91458671
159KDM2B_26808549_Chip-Seq_REH_Human0.91344758
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91304581
161RARB_27405468_Chip-Seq_BRAIN_Mouse0.90718048
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.90562724
163* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90210936
164RUNX2_22187159_ChIP-Seq_PCA_Human0.89795914
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89127277
166* CJUN_26792858_Chip-Seq_BT549_Human0.88768024
167TP63_22573176_ChIP-Seq_HFKS_Human0.87896085
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87713076
169ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87031765
170E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85757814
171TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85644833
172FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84130613
173NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82979435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.13026671
2MP0002139_abnormal_hepatobiliary_system4.90652108
3MP0003718_maternal_effect4.54840106
4MP0003880_abnormal_central_pattern3.89529498
5MP0005085_abnormal_gallbladder_physiolo3.79848547
6MP0008875_abnormal_xenobiotic_pharmacok3.28667379
7MP0005365_abnormal_bile_salt3.13782535
8MP0003950_abnormal_plasma_membrane2.83312405
9MP0003252_abnormal_bile_duct2.82250103
10MP0004859_abnormal_synaptic_plasticity2.68665566
11MP0010030_abnormal_orbit_morphology2.59094250
12MP0003329_amyloid_beta_deposits2.58024363
13MP0003191_abnormal_cellular_cholesterol2.53561762
14MP0001666_abnormal_nutrient_absorption2.42413278
15MP0005395_other_phenotype2.26458902
16MP0004270_analgesia2.24388268
17MP0003566_abnormal_cell_adhesion2.16990969
18MP0002837_dystrophic_cardiac_calcinosis2.13348697
19MP0010329_abnormal_lipoprotein_level2.11516875
20MP0000762_abnormal_tongue_morphology2.10879388
21MP0005023_abnormal_wound_healing2.09918609
22MP0005083_abnormal_biliary_tract2.04402405
23MP0002796_impaired_skin_barrier2.02863827
24MP0000566_synostosis1.95362326
25MP0003635_abnormal_synaptic_transmissio1.93772930
26MP0003941_abnormal_skin_development1.90902978
27MP0010678_abnormal_skin_adnexa1.80413468
28MP0005501_abnormal_skin_physiology1.76958972
29MP0009379_abnormal_foot_pigmentation1.75916656
30MP0008789_abnormal_olfactory_epithelium1.73343214
31MP0002876_abnormal_thyroid_physiology1.71571949
32MP0003693_abnormal_embryo_hatching1.71552749
33MP0010352_gastrointestinal_tract_polyps1.70996497
34MP0009745_abnormal_behavioral_response1.69776769
35MP0005332_abnormal_amino_acid1.69268589
36MP0001440_abnormal_grooming_behavior1.66832083
37MP0002063_abnormal_learning/memory/cond1.64168918
38MP0006276_abnormal_autonomic_nervous1.62231834
39MP0001501_abnormal_sleep_pattern1.61086731
40MP0000604_amyloidosis1.60315218
41MP0009780_abnormal_chondrocyte_physiolo1.58812235
42MP0005084_abnormal_gallbladder_morpholo1.58553577
43MP0003453_abnormal_keratinocyte_physiol1.57599941
44MP0008438_abnormal_cutaneous_collagen1.55226202
45MP0003699_abnormal_female_reproductive1.53055546
46MP0002064_seizures1.50714244
47MP0009840_abnormal_foam_cell1.48496615
48MP0005394_taste/olfaction_phenotype1.48075375
49MP0005499_abnormal_olfactory_system1.48075375
50MP0002060_abnormal_skin_morphology1.46945433
51MP0000537_abnormal_urethra_morphology1.45597105
52MP0010234_abnormal_vibrissa_follicle1.44300427
53MP0002572_abnormal_emotion/affect_behav1.43175440
54MP0003195_calcinosis1.40840554
55MP0002877_abnormal_melanocyte_morpholog1.39694268
56MP0001730_embryonic_growth_arrest1.38394140
57MP0009384_cardiac_valve_regurgitation1.37919915
58MP0002736_abnormal_nociception_after1.36095196
59MP0000467_abnormal_esophagus_morphology1.35178692
60MP0003806_abnormal_nucleotide_metabolis1.34837917
61MP0002098_abnormal_vibrissa_morphology1.34835016
62MP0000462_abnormal_digestive_system1.34552756
63MP0001216_abnormal_epidermal_layer1.31358902
64MP0002272_abnormal_nervous_system1.30653531
65MP0001968_abnormal_touch/_nociception1.29263837
66MP0000538_abnormal_urinary_bladder1.26439022
67MP0002295_abnormal_pulmonary_circulatio1.24891300
68MP0010386_abnormal_urinary_bladder1.24697142
69MP0000579_abnormal_nail_morphology1.23391625
70MP0002138_abnormal_hepatobiliary_system1.23308765
71* MP0002118_abnormal_lipid_homeostasis1.22909434
72MP0003868_abnormal_feces_composition1.22683600
73MP0004233_abnormal_muscle_weight1.22116505
74MP0002089_abnormal_postnatal_growth/wei1.19827147
75MP0003890_abnormal_embryonic-extraembry1.18439621
76MP0005257_abnormal_intraocular_pressure1.17595527
77MP0000383_abnormal_hair_follicle1.15365170
78MP0004272_abnormal_basement_membrane1.11826594
79MP0004883_abnormal_blood_vessel1.11351092
80MP0005076_abnormal_cell_differentiation1.09759375
81MP0003283_abnormal_digestive_organ1.09392537
82MP0003705_abnormal_hypodermis_morpholog1.06002358
83MP0000733_abnormal_muscle_development1.03303577
84MP0000013_abnormal_adipose_tissue1.02194531
85MP0005623_abnormal_meninges_morphology1.01817591
86MP0001188_hyperpigmentation1.01579772
87MP0000627_abnormal_mammary_gland1.01381564
88MP0008932_abnormal_embryonic_tissue0.99717450
89MP0004019_abnormal_vitamin_homeostasis0.99243998
90MP0000377_abnormal_hair_follicle0.98876813
91MP0010771_integument_phenotype0.98253407
92MP0000678_abnormal_parathyroid_gland0.98183376
93MP0005595_abnormal_vascular_smooth0.97265675
94MP0005164_abnormal_response_to0.96211998
95MP0000427_abnormal_hair_cycle0.95593453
96MP0009697_abnormal_copulation0.95511631
97* MP0001664_abnormal_digestion0.95394191
98MP0003183_abnormal_peptide_metabolism0.93664545
99MP0003077_abnormal_cell_cycle0.92980743
100MP0002734_abnormal_mechanical_nocicepti0.92569674
101MP0000778_abnormal_nervous_system0.91782305
102MP0001672_abnormal_embryogenesis/_devel0.91461238
103MP0005380_embryogenesis_phenotype0.91461238
104MP0004782_abnormal_surfactant_physiolog0.90352940
105MP0002733_abnormal_thermal_nociception0.89904669
106MP0005197_abnormal_uvea_morphology0.88841735
107MP0001929_abnormal_gametogenesis0.88804896
108MP0002184_abnormal_innervation0.88069830
109MP0002735_abnormal_chemical_nociception0.86388984
110MP0010368_abnormal_lymphatic_system0.84954427
111MP0005451_abnormal_body_composition0.84025417
112MP0001486_abnormal_startle_reflex0.84001985
113MP0005275_abnormal_skin_tensile0.83887081
114MP0001849_ear_inflammation0.83653620
115MP0001529_abnormal_vocalization0.83509718
116MP0003879_abnormal_hair_cell0.83076656
117MP0005535_abnormal_body_temperature0.82981140
118MP0004957_abnormal_blastocyst_morpholog0.80945047
119MP0001765_abnormal_ion_homeostasis0.78459463
120MP0004142_abnormal_muscle_tone0.78384090
121MP0001881_abnormal_mammary_gland0.77207087
122MP0002161_abnormal_fertility/fecundity0.76713120
123MP0002909_abnormal_adrenal_gland0.76115320
124MP0008874_decreased_physiological_sensi0.75964448
125MP0000609_abnormal_liver_physiology0.74076884
126MP0005503_abnormal_tendon_morphology0.73680326
127MP0005220_abnormal_exocrine_pancreas0.73570624
128MP0002233_abnormal_nose_morphology0.73119970
129MP0002896_abnormal_bone_mineralization0.73048939
130MP0002234_abnormal_pharynx_morphology0.72835224
131MP0002928_abnormal_bile_duct0.71346560
132MP0003091_abnormal_cell_migration0.71073001
133MP0002067_abnormal_sensory_capabilities0.71026165
134MP0003111_abnormal_nucleus_morphology0.70848705
135MP0000350_abnormal_cell_proliferation0.70188546
136MP0005448_abnormal_energy_balance0.70151725
137MP0002557_abnormal_social/conspecific_i0.69197290
138MP0004185_abnormal_adipocyte_glucose0.68147764
139MP0009053_abnormal_anal_canal0.67984399
140MP0000751_myopathy0.67456925
141MP0005408_hypopigmentation0.67365789
142MP0008961_abnormal_basal_metabolism0.67166276
143MP0005636_abnormal_mineral_homeostasis0.66867804
144MP0006292_abnormal_olfactory_placode0.66698171
145MP0005376_homeostasis/metabolism_phenot0.66289248
146MP0000003_abnormal_adipose_tissue0.66012162
147MP0002084_abnormal_developmental_patter0.65668211
148MP0005621_abnormal_cell_physiology0.65623122
149MP0005409_darkened_coat_color0.62968596
150MP0006138_congestive_heart_failure0.62867444
151MP0008872_abnormal_physiological_respon0.62369752
152MP0002210_abnormal_sex_determination0.62291468
153MP0001119_abnormal_female_reproductive0.62060485
154MP0000534_abnormal_ureter_morphology0.61818076
155MP0005386_behavior/neurological_phenoty0.61814256
156MP0004924_abnormal_behavior0.61814256
157MP0000230_abnormal_systemic_arterial0.61401753
158MP0001970_abnormal_pain_threshold0.60922551
159MP0004264_abnormal_extraembryonic_tissu0.60812132
160MP0005058_abnormal_lysosome_morphology0.60719683
161MP0005584_abnormal_enzyme/coenzyme_acti0.60414410
162MP0003984_embryonic_growth_retardation0.60194813
163MP0004484_altered_response_of0.60161052
164MP0000920_abnormal_myelination0.59787681
165MP0008004_abnormal_stomach_pH0.59613839
166MP0002085_abnormal_embryonic_tissue0.59580791
167MP0003045_fibrosis0.59523759
168MP0002066_abnormal_motor_capabilities/c0.59404456
169MP0005319_abnormal_enzyme/_coenzyme0.59214733
170* MP0002078_abnormal_glucose_homeostasis0.58857003
171MP0005187_abnormal_penis_morphology0.58743936
172MP0003632_abnormal_nervous_system0.58482361

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.91463277
2Hypobetalipoproteinemia (HP:0003563)4.61166758
3Intrahepatic cholestasis (HP:0001406)4.56893274
4Cerebral inclusion bodies (HP:0100314)4.56493851
5Neurofibrillary tangles (HP:0002185)4.31016430
6Prolonged partial thromboplastin time (HP:0003645)4.18502390
7Xanthomatosis (HP:0000991)4.09394105
8Focal motor seizures (HP:0011153)4.00317746
9Hyperventilation (HP:0002883)3.93332818
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88212808
11Osteomalacia (HP:0002749)3.56438946
12Flat acetabular roof (HP:0003180)3.53309889
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44399674
14Atrophic scars (HP:0001075)3.27966320
15Hypolipoproteinemia (HP:0010981)3.15526926
16Short nail (HP:0001799)3.10382579
17Milia (HP:0001056)3.08077535
18Conjugated hyperbilirubinemia (HP:0002908)3.07463415
19Hypokinesia (HP:0002375)3.01830066
20Focal seizures (HP:0007359)3.01508766
21Acanthocytosis (HP:0001927)3.00738604
22Lip pit (HP:0100267)2.99960964
23Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99582457
24Abnormality of carpal bone ossification (HP:0006257)2.98445663
25Spontaneous abortion (HP:0005268)2.96631095
26Absence seizures (HP:0002121)2.87501846
27Abnormality of the distal phalanges of the toes (HP:0010182)2.86705948
28Atonic seizures (HP:0010819)2.85866313
29Spinal cord compression (HP:0002176)2.85704030
30Hyperlipoproteinemia (HP:0010980)2.84063014
31Fat malabsorption (HP:0002630)2.82521022
32Ileus (HP:0002595)2.78398295
33Abnormality of the common coagulation pathway (HP:0010990)2.77675637
34Complement deficiency (HP:0004431)2.76985723
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72253773
36Upper limb amyotrophy (HP:0009129)2.68545879
37Distal upper limb amyotrophy (HP:0007149)2.68545879
38Male infertility (HP:0003251)2.66012912
39Onycholysis (HP:0001806)2.60661764
40Skin nodule (HP:0200036)2.58448154
41Distal lower limb muscle weakness (HP:0009053)2.54331244
42Popliteal pterygium (HP:0009756)2.52617182
43Anterior segment dysgenesis (HP:0007700)2.51117536
44Pili torti (HP:0003777)2.47770064
45Malnutrition (HP:0004395)2.45926217
46Cholecystitis (HP:0001082)2.44257935
47Abnormal gallbladder physiology (HP:0012438)2.44257935
48Epidermoid cyst (HP:0200040)2.43601082
49Abnormal ossification of hand bones (HP:0005921)2.42467970
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.39380100
51Absent/shortened dynein arms (HP:0200106)2.39380100
52Amyloidosis (HP:0011034)2.37897797
53Ankle contracture (HP:0006466)2.37173263
54Hand muscle atrophy (HP:0009130)2.35832304
55Sensorimotor neuropathy (HP:0007141)2.35505895
56Fragile nails (HP:0001808)2.35453896
57Dialeptic seizures (HP:0011146)2.34967241
58Reduced subcutaneous adipose tissue (HP:0003758)2.34252478
59Abnormality of the Achilles tendon (HP:0005109)2.33313714
60Hypoalphalipoproteinemia (HP:0003233)2.30632585
61Facial hemangioma (HP:0000329)2.30118018
62Right ventricular cardiomyopathy (HP:0011663)2.29855172
63Entropion (HP:0000621)2.29853682
64Generalized tonic-clonic seizures (HP:0002069)2.28542856
65Sparse eyelashes (HP:0000653)2.28472909
66Ketosis (HP:0001946)2.28315874
67Vascular tortuosity (HP:0004948)2.27239348
68Secondary amenorrhea (HP:0000869)2.27012187
69Scanning speech (HP:0002168)2.23934222
70Steatorrhea (HP:0002570)2.23798467
71Pterygium (HP:0001059)2.23751899
72Rickets (HP:0002748)2.22010236
73Hydroureter (HP:0000072)2.21832053
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.21290141
75Osteolytic defects of the hand bones (HP:0009699)2.21290141
76Mitral stenosis (HP:0001718)2.20615432
77Abnormal hand bone ossification (HP:0010660)2.18895034
78Status epilepticus (HP:0002133)2.18429275
79Alopecia of scalp (HP:0002293)2.17991519
80Hypergonadotropic hypogonadism (HP:0000815)2.16759455
81Hypercholesterolemia (HP:0003124)2.14831622
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12279220
83Increased connective tissue (HP:0009025)2.10843314
84Insidious onset (HP:0003587)2.10297288
85Termporal pattern (HP:0011008)2.10297288
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09795465
87Proximal tubulopathy (HP:0000114)2.09702795
88Vertebral compression fractures (HP:0002953)2.08752673
89Periodontitis (HP:0000704)2.07307734
90Natal tooth (HP:0000695)2.07114489
91Thickened helices (HP:0000391)2.06640873
92Supranuclear gaze palsy (HP:0000605)2.05995727
93Premature rupture of membranes (HP:0001788)2.05431764
94Global brain atrophy (HP:0002283)2.05105205
95Abnormality of the intrinsic pathway (HP:0010989)2.04468765
96Testicular atrophy (HP:0000029)2.04338790
97Confusion (HP:0001289)2.03659185
98Protrusio acetabuli (HP:0003179)2.02932875
99Fragile skin (HP:0001030)2.02702831
100Hypoplasia of dental enamel (HP:0006297)2.02527840
101Drooling (HP:0002307)2.01791442
102Excessive salivation (HP:0003781)2.01791442
103Cervical subluxation (HP:0003308)2.01460835
104Cerebral hemorrhage (HP:0001342)2.01154725
105Infantile muscular hypotonia (HP:0008947)2.00769061
106Achilles tendon contracture (HP:0001771)2.00157849
107Apathy (HP:0000741)1.99896871
108Glucose intolerance (HP:0000833)1.99425408
109Microglossia (HP:0000171)1.99219921
110Distal lower limb amyotrophy (HP:0008944)1.98750143
111Trismus (HP:0000211)1.98182204
112Infertility (HP:0000789)1.97668296
113Hypochromic microcytic anemia (HP:0004840)1.97495248
114Nuclear cataract (HP:0100018)1.97439908
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.97254480
116Cardiovascular calcification (HP:0011915)1.94879325
117Absent speech (HP:0001344)1.94794598
118Shallow orbits (HP:0000586)1.93949568
119Epileptic encephalopathy (HP:0200134)1.93283733
120Plantar hyperkeratosis (HP:0007556)1.92533515
121Nail dystrophy (HP:0008404)1.92067622
122Epileptiform EEG discharges (HP:0011182)1.90067243
123Hyperglycinemia (HP:0002154)1.89815615
124Poikiloderma (HP:0001029)1.89804166
125Prolonged neonatal jaundice (HP:0006579)1.88878569
126Abnormality of complement system (HP:0005339)1.88422194
127Abnormal hair laboratory examination (HP:0003328)1.87728622
128Diminished motivation (HP:0000745)1.87335725
129Joint hemorrhage (HP:0005261)1.87086078
130Hyperactive renin-angiotensin system (HP:0000841)1.85842145
131Fair hair (HP:0002286)1.83670808
132Abdominal situs inversus (HP:0003363)1.83139310
133Abnormality of abdominal situs (HP:0011620)1.83139310
134Buphthalmos (HP:0000557)1.82423003
135Hypophosphatemic rickets (HP:0004912)1.82101653
136Bifid scrotum (HP:0000048)1.82050417
137Papillary thyroid carcinoma (HP:0002895)1.82005307
138Ketoacidosis (HP:0001993)1.80654449
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79647228
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.79647228
141Hyperammonemia (HP:0001987)1.79334728
142Retinal dysplasia (HP:0007973)1.78945951
143Acanthosis nigricans (HP:0000956)1.78872313
144Aplasia of the musculature (HP:0100854)1.78294169
145Tibial bowing (HP:0002982)1.77839702
146Vascular calcification (HP:0004934)1.77506799
147Congenital malformation of the right heart (HP:0011723)1.77208131
148Double outlet right ventricle (HP:0001719)1.77208131
149Peritonitis (HP:0002586)1.76987226
150Abnormality of pyrimidine metabolism (HP:0004353)1.76592392
151Selective tooth agenesis (HP:0001592)1.76522485
152Elevated alkaline phosphatase (HP:0003155)1.75457707
153Abnormality of the corticospinal tract (HP:0002492)1.74585107
154Focal segmental glomerulosclerosis (HP:0000097)1.74578264
155Generalized myoclonic seizures (HP:0002123)1.74274101
156Neonatal death (HP:0003811)1.73972334
157Dysmetria (HP:0001310)1.73187350
158Chin dimple (HP:0010751)1.72681916
159Subcapsular cataract (HP:0000523)1.72534250
160Aortic aneurysm (HP:0004942)1.71525052
161Visual hallucinations (HP:0002367)1.71453058
162Abnormal tarsal ossification (HP:0008369)1.71113192
163Advanced eruption of teeth (HP:0006288)1.71035022
164Glomerulosclerosis (HP:0000096)1.70897750
165Increased mean platelet volume (HP:0011877)1.70132416
166Delusions (HP:0000746)1.68010838
167Hydroxyprolinuria (HP:0003080)1.67222240
168Abnormality of proline metabolism (HP:0010907)1.67222240
169Abnormality of methionine metabolism (HP:0010901)1.66909494
170Lower limb hyperreflexia (HP:0002395)1.66681565
171Arterial tortuosity (HP:0005116)1.65384484
172Abnormality of glycine metabolism (HP:0010895)1.65305483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.27924194
2LMTK23.58138507
3NTRK33.19532460
4RIPK42.97200672
5FRK2.68364910
6CASK2.62594848
7PNCK2.34310401
8MAP3K42.33788705
9CDK122.33440632
10IRAK32.21768301
11FER2.19734020
12EPHA22.13198432
13PAK32.09795799
14NME12.09653085
15TRIB32.04624002
16CAMK2B1.92128215
17PAK41.84198923
18PTK2B1.82422193
19STK391.75880599
20TESK21.67939050
21MST1R1.66751747
22PBK1.66554480
23NME21.66514775
24LATS21.66242866
25MAP2K41.65525307
26CDK91.65499033
27PTK21.59018840
28CDK81.58485378
29NTRK11.57754820
30MET1.57633406
31ARAF1.56273771
32CAMK2A1.55684578
33RIPK11.49684335
34BMPR21.49045018
35PRKCI1.45395347
36PLK21.45077800
37FGR1.44890949
38WNK41.43537848
39BCR1.41375800
40MINK11.39907338
41ERBB41.37106941
42ICK1.36517264
43MAP3K21.36110166
44TTK1.34326506
45DDR21.33628495
46GRK51.33449817
47KSR11.31384582
48KSR21.29878335
49NEK61.29716768
50AURKA1.29527386
51STK241.26978783
52MAP3K121.26585966
53CAMK2D1.23135861
54PIK3CA1.20950349
55MAP2K71.19854835
56EPHB21.18831764
57MELK1.15465004
58CAMK2G1.15282271
59PAK61.10226063
60OXSR11.07971649
61MST41.07850569
62MAP2K11.07629909
63ILK1.04734970
64MAP3K91.04400097
65TAOK31.02573640
66DAPK21.02519615
67BUB11.02245174
68GRK61.01871614
69STK380.99766397
70TRIM280.98129293
71CDK70.97154687
72UHMK10.95951943
73LATS10.93276984
74MAPKAPK50.92048772
75BRSK10.91317612
76PRKCE0.89894358
77SCYL20.89566313
78MTOR0.88539217
79ROCK20.88302374
80PAK20.87714398
81PRKCQ0.86996893
82MAP3K80.85859634
83CDK50.84847708
84MAP2K20.82950507
85CSNK1G20.81041180
86LIMK10.79533756
87MYLK0.79211922
88PRKCG0.77093984
89GRK70.76734781
90MAPKAPK30.76351730
91ABL20.76148712
92MAP3K30.76068204
93INSRR0.74463240
94AKT30.74442944
95MAPK150.70147967
96STK100.69017236
97RAF10.68812126
98BCKDK0.68302305
99SMG10.68248040
100LRRK20.66318510
101MAP3K130.64524679
102DMPK0.64160634
103SIK20.64086256
104PIK3CG0.63699928
105PRKG20.60981473
106PTK60.60432167
107PIM20.60318149
108STK30.60221053
109ADRBK10.60194137
110TESK10.60149542
111TTN0.60139560
112EIF2AK10.59517320
113MOS0.59244700
114CDK140.58953539
115CSNK1G30.58136669
116DAPK10.57174088
117EPHB10.55843741
118RET0.54502745
119AURKB0.54135751
120PLK10.53466422
121CSNK1A1L0.51411871
122CAMK1G0.50306012
123CDK180.48792680
124CSNK1E0.48400713
125CDK150.47700882
126PRKCZ0.47565006
127TAOK20.47520056
128PKN20.47016280
129PAK10.46920485
130NEK20.46904718
131MAPK110.46887521
132PDGFRA0.46816968
133MAP3K10.46798495
134MAP3K60.45737034
135WNK10.45563505
136MAP3K70.45500768
137BRAF0.45046427
138FYN0.44705274
139RPS6KB20.44503757
140ERN10.43271882
141SGK10.42300690
142NEK90.41160966
143SIK10.40431536
144AKT20.39980414
145NEK10.39767210
146CSNK1G10.39071574
147CHEK10.38542104
148BMX0.38455906
149PRKACA0.37111528
150VRK20.34580053
151TRPM70.33842545
152EIF2AK30.31779400
153ROCK10.29734137
154MUSK0.28922179
155PDPK10.28430645
156FLT30.25656642
157PRKD20.22754672
158MAPKAPK20.22737704
159CAMK1D0.19088362
160PHKG10.18178039
161PHKG20.18178039

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.68722511
2Nicotine addiction_Homo sapiens_hsa050332.55147384
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18397033
4Sulfur metabolism_Homo sapiens_hsa009202.18330187
5Drug metabolism - other enzymes_Homo sapiens_hsa009832.14258150
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89716055
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88342845
8Arginine biosynthesis_Homo sapiens_hsa002201.87803059
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82384078
10Nitrogen metabolism_Homo sapiens_hsa009101.77380953
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76954124
12Complement and coagulation cascades_Homo sapiens_hsa046101.76144873
13Fat digestion and absorption_Homo sapiens_hsa049751.74826132
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.71819741
15Tryptophan metabolism_Homo sapiens_hsa003801.69980894
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.65474526
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.62346846
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61842812
19Butanoate metabolism_Homo sapiens_hsa006501.58842080
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57859508
21Histidine metabolism_Homo sapiens_hsa003401.57709007
22Bile secretion_Homo sapiens_hsa049761.57360416
23Long-term potentiation_Homo sapiens_hsa047201.56578391
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53357391
25Amphetamine addiction_Homo sapiens_hsa050311.53044055
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.47691814
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46346901
28Ovarian steroidogenesis_Homo sapiens_hsa049131.46141842
29Chemical carcinogenesis_Homo sapiens_hsa052041.43488119
30Steroid biosynthesis_Homo sapiens_hsa001001.41745752
31Adherens junction_Homo sapiens_hsa045201.37497789
32Galactose metabolism_Homo sapiens_hsa000521.36765889
33Cell cycle_Homo sapiens_hsa041101.36046126
34Thyroid cancer_Homo sapiens_hsa052161.35163309
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30462714
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28308261
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27003589
38Glutamatergic synapse_Homo sapiens_hsa047241.25002791
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24901788
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20689534
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20573870
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19483419
43Fatty acid elongation_Homo sapiens_hsa000621.19470953
44Biosynthesis of amino acids_Homo sapiens_hsa012301.19153296
45Sulfur relay system_Homo sapiens_hsa041221.18580238
46GABAergic synapse_Homo sapiens_hsa047271.18123507
47Folate biosynthesis_Homo sapiens_hsa007901.17577656
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16958241
49Salivary secretion_Homo sapiens_hsa049701.16665207
50Taste transduction_Homo sapiens_hsa047421.16293608
51Pentose phosphate pathway_Homo sapiens_hsa000301.16261970
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15870376
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15438241
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15293644
55Fatty acid degradation_Homo sapiens_hsa000711.15172110
56Circadian entrainment_Homo sapiens_hsa047131.14226637
57Serotonergic synapse_Homo sapiens_hsa047261.13896458
58PPAR signaling pathway_Homo sapiens_hsa033201.13309005
59Vitamin digestion and absorption_Homo sapiens_hsa049771.11602479
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10549620
61Pyruvate metabolism_Homo sapiens_hsa006201.09798222
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.09439658
63Vitamin B6 metabolism_Homo sapiens_hsa007501.09121395
64Small cell lung cancer_Homo sapiens_hsa052221.08000131
65Peroxisome_Homo sapiens_hsa041461.07823550
66Focal adhesion_Homo sapiens_hsa045101.07266211
67Fructose and mannose metabolism_Homo sapiens_hsa000511.06643141
68Long-term depression_Homo sapiens_hsa047301.05986988
69Renin secretion_Homo sapiens_hsa049241.03412435
70Starch and sucrose metabolism_Homo sapiens_hsa005001.03409908
71Glycosaminoglycan degradation_Homo sapiens_hsa005311.02447781
72N-Glycan biosynthesis_Homo sapiens_hsa005101.02218427
73Tight junction_Homo sapiens_hsa045301.01282352
74Alzheimers disease_Homo sapiens_hsa050101.00682757
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00216132
76Dopaminergic synapse_Homo sapiens_hsa047280.98580809
77Mineral absorption_Homo sapiens_hsa049780.98506863
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.97188688
79Oxidative phosphorylation_Homo sapiens_hsa001900.97143367
80Basal transcription factors_Homo sapiens_hsa030220.96748201
81Morphine addiction_Homo sapiens_hsa050320.96706405
82Carbon metabolism_Homo sapiens_hsa012000.96599266
83Cocaine addiction_Homo sapiens_hsa050300.92144543
84Base excision repair_Homo sapiens_hsa034100.91344805
85Caffeine metabolism_Homo sapiens_hsa002320.90498759
86Phenylalanine metabolism_Homo sapiens_hsa003600.88255887
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88092920
88Retinol metabolism_Homo sapiens_hsa008300.87931143
89Sphingolipid metabolism_Homo sapiens_hsa006000.85966807
90Gastric acid secretion_Homo sapiens_hsa049710.85325164
91Inositol phosphate metabolism_Homo sapiens_hsa005620.85197922
92Insulin secretion_Homo sapiens_hsa049110.84915971
93Fatty acid metabolism_Homo sapiens_hsa012120.84803743
94Proteoglycans in cancer_Homo sapiens_hsa052050.82966288
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82962765
96Hippo signaling pathway_Homo sapiens_hsa043900.82599536
97Tyrosine metabolism_Homo sapiens_hsa003500.82229657
98Nucleotide excision repair_Homo sapiens_hsa034200.81695404
99Propanoate metabolism_Homo sapiens_hsa006400.81417092
100Axon guidance_Homo sapiens_hsa043600.80959010
101p53 signaling pathway_Homo sapiens_hsa041150.80803612
102Vibrio cholerae infection_Homo sapiens_hsa051100.80641605
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78925026
104Collecting duct acid secretion_Homo sapiens_hsa049660.78207884
105Lysine degradation_Homo sapiens_hsa003100.78204806
106Arginine and proline metabolism_Homo sapiens_hsa003300.77112159
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76421439
108Thyroid hormone synthesis_Homo sapiens_hsa049180.75011760
109TGF-beta signaling pathway_Homo sapiens_hsa043500.73242159
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70937441
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69599197
112Calcium signaling pathway_Homo sapiens_hsa040200.68598819
113Gap junction_Homo sapiens_hsa045400.67675235
114Prion diseases_Homo sapiens_hsa050200.65374854
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64605623
116African trypanosomiasis_Homo sapiens_hsa051430.64101649
117Glutathione metabolism_Homo sapiens_hsa004800.63973813
118Synaptic vesicle cycle_Homo sapiens_hsa047210.63126114
119Mismatch repair_Homo sapiens_hsa034300.62758383
120Pancreatic secretion_Homo sapiens_hsa049720.61621149
121Glycerolipid metabolism_Homo sapiens_hsa005610.60358360
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60006669
123Oocyte meiosis_Homo sapiens_hsa041140.59732681
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59690808
125Circadian rhythm_Homo sapiens_hsa047100.58302238
126GnRH signaling pathway_Homo sapiens_hsa049120.57767052
127Cholinergic synapse_Homo sapiens_hsa047250.57415055
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57359158
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56601648
130Amoebiasis_Homo sapiens_hsa051460.56567820
131Oxytocin signaling pathway_Homo sapiens_hsa049210.56465943
132DNA replication_Homo sapiens_hsa030300.55812491
133ABC transporters_Homo sapiens_hsa020100.55430553
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54135055
135beta-Alanine metabolism_Homo sapiens_hsa004100.53470047
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52680581
137Melanogenesis_Homo sapiens_hsa049160.52558450
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52236754
139Endometrial cancer_Homo sapiens_hsa052130.50192613
140Cardiac muscle contraction_Homo sapiens_hsa042600.49841665
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49441446
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.48394768
143Parkinsons disease_Homo sapiens_hsa050120.47219815
144Pancreatic cancer_Homo sapiens_hsa052120.46858486
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45122408
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44948319
147Staphylococcus aureus infection_Homo sapiens_hsa051500.43303087
148ECM-receptor interaction_Homo sapiens_hsa045120.43301298
149MicroRNAs in cancer_Homo sapiens_hsa052060.42869298
150ErbB signaling pathway_Homo sapiens_hsa040120.42842658
151Bladder cancer_Homo sapiens_hsa052190.42592802
152Renal cell carcinoma_Homo sapiens_hsa052110.42569051
153Glucagon signaling pathway_Homo sapiens_hsa049220.42067979
154Protein digestion and absorption_Homo sapiens_hsa049740.41004104
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.40905795
156Metabolic pathways_Homo sapiens_hsa011000.40635714
157cAMP signaling pathway_Homo sapiens_hsa040240.39819056

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