GPR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)8.36942494
2endothelium development (GO:0003158)7.85453167
3lymphangiogenesis (GO:0001946)7.17122163
4cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.58801450
5vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.91360014
6morphogenesis of an endothelium (GO:0003159)5.50396909
7endothelial tube morphogenesis (GO:0061154)5.50396909
8endothelial cell differentiation (GO:0045446)5.03585308
9positive regulation of vasculogenesis (GO:2001214)4.88508302
10retina vasculature morphogenesis in camera-type eye (GO:0061299)4.76196071
11transcytosis (GO:0045056)4.66751683
12ovulation from ovarian follicle (GO:0001542)4.41320164
13blood vessel endothelial cell migration (GO:0043534)4.39190539
14embryonic heart tube development (GO:0035050)4.31026489
15sprouting angiogenesis (GO:0002040)4.22911281
16heart trabecula formation (GO:0060347)4.14989484
17regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.13419019
18cardiac myofibril assembly (GO:0055003)4.07445613
19trabecula morphogenesis (GO:0061383)4.06863318
20negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.00499915
21plasma membrane repair (GO:0001778)4.00364653
22heart trabecula morphogenesis (GO:0061384)3.99651466
23ventricular trabecula myocardium morphogenesis (GO:0003222)3.98753777
24negative regulation of blood vessel endothelial cell migration (GO:0043537)3.98474711
25patterning of blood vessels (GO:0001569)3.97658078
26regulation of vasculogenesis (GO:2001212)3.97119330
27endothelial cell morphogenesis (GO:0001886)3.94859478
28sarcomere organization (GO:0045214)3.94039360
29piRNA metabolic process (GO:0034587)3.92870280
30establishment of endothelial barrier (GO:0061028)3.91167120
31surfactant homeostasis (GO:0043129)3.80987558
32vasculogenesis (GO:0001570)3.78965937
33peptidyl-tyrosine autophosphorylation (GO:0038083)3.76739436
34negative regulation of endothelial cell migration (GO:0010596)3.74636865
35adhesion of symbiont to host (GO:0044406)3.73482174
36regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.69785010
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.64075815
38ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.63435933
39regulation of actin filament-based movement (GO:1903115)3.63226542
40regulation of endothelial cell differentiation (GO:0045601)3.59504339
41venous blood vessel morphogenesis (GO:0048845)3.48700328
42negative regulation of nitric-oxide synthase activity (GO:0051001)3.44685639
43myofibril assembly (GO:0030239)3.44573057
44cell migration involved in sprouting angiogenesis (GO:0002042)3.43390353
45positive regulation of protein kinase C signaling (GO:0090037)3.41671678
46L-fucose catabolic process (GO:0042355)3.40400525
47fucose catabolic process (GO:0019317)3.40400525
48L-fucose metabolic process (GO:0042354)3.40400525
49endothelial cell chemotaxis (GO:0035767)3.34110436
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.31976697
51basement membrane organization (GO:0071711)3.30772800
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29814095
53labyrinthine layer development (GO:0060711)3.28639476
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26842829
55cardiac muscle tissue morphogenesis (GO:0055008)3.26458727
56atrial cardiac muscle cell action potential (GO:0086014)3.24922298
57cAMP catabolic process (GO:0006198)3.20975451
58mRNA transcription from RNA polymerase II promoter (GO:0042789)3.20746712
59regulation of cardioblast differentiation (GO:0051890)3.19876134
60regulation of cardiac muscle cell contraction (GO:0086004)3.19723649
61regulation of sarcomere organization (GO:0060297)3.19606750
62positive regulation of meiosis (GO:0045836)3.18321424
63glomerular filtration (GO:0003094)3.16038870
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15209840
65regulation of vascular permeability (GO:0043114)3.13973385
66cyclic nucleotide catabolic process (GO:0009214)3.13051083
67endoderm formation (GO:0001706)3.12489184
68blood vessel remodeling (GO:0001974)3.12423427
69detection of light stimulus involved in visual perception (GO:0050908)3.10881735
70detection of light stimulus involved in sensory perception (GO:0050962)3.10881735
71negative regulation of epithelial cell migration (GO:0010633)3.10335214
72blood vessel maturation (GO:0001955)3.09788095
73phagocytosis, recognition (GO:0006910)3.09700468
74renal tubule morphogenesis (GO:0061333)3.07899834
75behavioral response to nicotine (GO:0035095)3.07711817
76endothelial cell migration (GO:0043542)3.06939848
77chemical homeostasis within a tissue (GO:0048875)3.06748382
78muscle tissue morphogenesis (GO:0060415)3.03922613
79cardiac muscle cell development (GO:0055013)3.02127966
80renal filtration (GO:0097205)3.01898534
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01038733
82regulation of endothelial cell migration (GO:0010594)3.00547868
83retinal cone cell development (GO:0046549)3.00287679
84cardiac muscle cell proliferation (GO:0060038)2.99365110
85Notch signaling involved in heart development (GO:0061314)2.98001083
86calcium-mediated signaling using intracellular calcium source (GO:0035584)2.97640135
87wound healing, spreading of epidermal cells (GO:0035313)2.96403214
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95581775
89regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.93509350
90regulation of the force of heart contraction (GO:0002026)2.93018295
91positive regulation of meiotic cell cycle (GO:0051446)2.91954872
92endothelial cell proliferation (GO:0001935)2.91155251
93protein polyglutamylation (GO:0018095)2.90244636
94cardiac cell development (GO:0055006)2.87763721
95DNA methylation involved in gamete generation (GO:0043046)2.87240183
96platelet dense granule organization (GO:0060155)2.87224976
97response to pheromone (GO:0019236)2.86664586
98adult heart development (GO:0007512)2.85561082
99ventricular cardiac muscle cell action potential (GO:0086005)2.85111689
100gap junction assembly (GO:0016264)2.83959092
101muscle organ morphogenesis (GO:0048644)2.83567460
102regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83071775
103negative regulation of Rho protein signal transduction (GO:0035024)2.82449398
104negative regulation of potassium ion transmembrane transport (GO:1901380)2.81845771
105coronary vasculature morphogenesis (GO:0060977)2.81645039
106heme transport (GO:0015886)2.80756633
107regulation of relaxation of muscle (GO:1901077)2.79541497
108cardiac muscle contraction (GO:0060048)2.79385390
109fatty acid transmembrane transport (GO:1902001)2.78676417
110mRNA transcription (GO:0009299)2.78529590
111trabecula formation (GO:0060343)2.78411376
112arginine catabolic process (GO:0006527)2.78391013
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77985817
114regulation of blood vessel endothelial cell migration (GO:0043535)2.77346711
115positive regulation of glycolytic process (GO:0045821)2.77224949
116carnitine shuttle (GO:0006853)2.77108390
117regulation of tight junction assembly (GO:2000810)2.76862006
118positive regulation of endothelial cell migration (GO:0010595)2.75652053
119negative regulation of DNA biosynthetic process (GO:2000279)2.74921581
120auditory receptor cell stereocilium organization (GO:0060088)2.73606372
121endothelial cell development (GO:0001885)2.71175927
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69564297
123potassium ion import (GO:0010107)2.68971747
124vasculature development (GO:0001944)2.68870049
125negative regulation of stress fiber assembly (GO:0051497)2.67033779
126positive regulation of endothelial cell proliferation (GO:0001938)2.66321160
127muscle filament sliding (GO:0030049)2.64656085
128regulation of meiosis I (GO:0060631)2.64652927
129cellular response to ATP (GO:0071318)2.57081154
130regulation of action potential (GO:0098900)2.56493890
131sulfation (GO:0051923)2.54842710
132gamma-aminobutyric acid transport (GO:0015812)2.54361169
133plasma membrane fusion (GO:0045026)2.52162605
134nephron epithelium development (GO:0072009)2.50125815
135angiogenesis involved in wound healing (GO:0060055)2.48143732
136positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47402552
137artery development (GO:0060840)2.45252845
138epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.44397085
139indolalkylamine metabolic process (GO:0006586)2.40893002
140negative regulation of axon extension involved in axon guidance (GO:0048843)2.40220327
141indole-containing compound catabolic process (GO:0042436)2.39994453
142indolalkylamine catabolic process (GO:0046218)2.39994453
143tryptophan catabolic process (GO:0006569)2.39994453
144nephron epithelium morphogenesis (GO:0072088)2.39596277
145nephron tubule morphogenesis (GO:0072078)2.39596277
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39158517
147phosphorelay signal transduction system (GO:0000160)2.35112020
148kynurenine metabolic process (GO:0070189)2.34405191
149inner ear receptor stereocilium organization (GO:0060122)2.32323658
150male meiosis (GO:0007140)2.31664527
151activin receptor signaling pathway (GO:0032924)2.31298206
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30775297
153glycosphingolipid biosynthetic process (GO:0006688)2.30745029
154negative regulation of systemic arterial blood pressure (GO:0003085)2.30678192
155inositol phosphate catabolic process (GO:0071545)2.29999197
156positive regulation of endothelial cell differentiation (GO:0045603)2.29525283
157regulation of hippo signaling (GO:0035330)2.27700655
158neuronal action potential propagation (GO:0019227)2.26378264
159positive regulation of cardiac muscle cell differentiation (GO:2000727)2.25347098
160cilium morphogenesis (GO:0060271)2.24525865
161positive regulation of glomerulus development (GO:0090193)2.23420319
162negative regulation of mast cell activation (GO:0033004)2.23094053
163reflex (GO:0060004)2.22622224
164cellular ketone body metabolic process (GO:0046950)2.22512038
165C4-dicarboxylate transport (GO:0015740)2.22346448
166nitric oxide mediated signal transduction (GO:0007263)2.22286821
167positive regulation of guanylate cyclase activity (GO:0031284)2.22083605
168response to gravity (GO:0009629)2.22064495
169proline transport (GO:0015824)2.19045730
170positive regulation of action potential (GO:0045760)2.18013415
171neuronal action potential (GO:0019228)2.16585762
172dendritic spine morphogenesis (GO:0060997)2.15880906
173lymph vessel development (GO:0001945)10.2533050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.72062378
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.72062378
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.72062378
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09544721
5ZNF263_19887448_ChIP-Seq_K562_Human3.90698876
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.90256313
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.43017422
8ZNF274_21170338_ChIP-Seq_K562_Hela3.30746921
9VDR_22108803_ChIP-Seq_LS180_Human3.23630911
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.21304148
11GBX2_23144817_ChIP-Seq_PC3_Human3.06973667
12GATA2_21666600_ChIP-Seq_HMVEC_Human3.00192704
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93763666
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.91817368
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.78155966
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69013473
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65285304
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.49038888
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.40647967
20CLOCK_20551151_ChIP-Seq_293T_Human2.36445007
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.33519280
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31903833
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.27253017
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.27158084
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25166799
26IGF1R_20145208_ChIP-Seq_DFB_Human2.23125102
27* ELK3_25401928_ChIP-Seq_HUVEC_Human2.22072332
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14574618
29BCAT_22108803_ChIP-Seq_LS180_Human2.13848798
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.08800472
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08005733
32HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07394451
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05867855
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05330050
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01720219
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99081488
37P300_19829295_ChIP-Seq_ESCs_Human1.95923925
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95145685
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.94385865
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94151213
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93641872
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.93291316
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.93291316
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91630550
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90225885
46EZH2_22144423_ChIP-Seq_EOC_Human1.88112166
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.83757938
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83029360
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81343422
50GATA1_22025678_ChIP-Seq_K562_Human1.78295952
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76742973
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.76417768
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75718112
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74916799
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.69833362
56SMAD4_21799915_ChIP-Seq_A2780_Human1.66263393
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.65359039
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64178036
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63946601
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.63475411
61TAF15_26573619_Chip-Seq_HEK293_Human1.61741981
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59759517
63* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58722936
64FUS_26573619_Chip-Seq_HEK293_Human1.57841204
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57172951
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56479615
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55416852
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55111332
69ER_23166858_ChIP-Seq_MCF-7_Human1.54055441
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52942548
71AR_25329375_ChIP-Seq_VCAP_Human1.52613842
72STAT3_23295773_ChIP-Seq_U87_Human1.48844489
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47606023
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.47455683
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45869593
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45223999
77CBP_20019798_ChIP-Seq_JUKART_Human1.45223999
78TCF4_23295773_ChIP-Seq_U87_Human1.44506242
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44247749
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.43879563
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42558579
82TCF4_22108803_ChIP-Seq_LS180_Human1.42311548
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.39044004
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38490493
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37522259
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36918281
87EWS_26573619_Chip-Seq_HEK293_Human1.36794729
88* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36177275
89RACK7_27058665_Chip-Seq_MCF-7_Human1.35291277
90GATA1_19941826_ChIP-Seq_K562_Human1.33320276
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.32989822
92KDM2B_26808549_Chip-Seq_K562_Human1.32846521
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32391065
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.31572900
95RUNX2_22187159_ChIP-Seq_PCA_Human1.30459099
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27914768
97NANOG_19829295_ChIP-Seq_ESCs_Human1.27890390
98SOX2_19829295_ChIP-Seq_ESCs_Human1.27890390
99* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24638039
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.24475820
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24107609
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22904466
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21882331
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21375274
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21140169
106CDX2_22108803_ChIP-Seq_LS180_Human1.20599037
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20060208
108RNF2_27304074_Chip-Seq_NSC_Mouse1.19872660
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.19248216
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.18822899
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18544949
112TCF7_22412390_ChIP-Seq_EML_Mouse1.17449468
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.15343914
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15300936
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13821146
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13821146
117TP53_22573176_ChIP-Seq_HFKS_Human1.13782975
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13781144
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13262332
120* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13043900
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12966953
122CJUN_26792858_Chip-Seq_BT549_Human1.12111617
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11693256
124NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11669814
125* LXR_22292898_ChIP-Seq_THP-1_Human1.11483900
126KDM2B_26808549_Chip-Seq_DND41_Human1.10965664
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10639182
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09180915
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08755828
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08315644
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07966045
132REST_21632747_ChIP-Seq_MESCs_Mouse1.07588105
133KDM2B_26808549_Chip-Seq_REH_Human1.07561312
134MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07241833
135* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06548094
136POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06194384
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06117574
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.06098224
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06013947
140EZH2_27294783_Chip-Seq_ESCs_Mouse1.05250155
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04682242
142FOXO3_23340844_ChIP-Seq_DLD1_Human1.04490064
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04471935
144EZH2_27304074_Chip-Seq_ESCs_Mouse1.04146837
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03961475
146* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03925015
147RXR_22108803_ChIP-Seq_LS180_Human1.03746393
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03719426
149NANOG_18555785_Chip-Seq_ESCs_Mouse1.03344235
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03309785
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03287081
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03274977
153DROSHA_22980978_ChIP-Seq_HELA_Human1.03193564
154RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02894429
155GATA3_21878914_ChIP-Seq_MCF-7_Human1.02812130
156TCF4_18268006_ChIP-ChIP_LS174T_Human1.02761304
157AR_21572438_ChIP-Seq_LNCaP_Human1.02682375
158CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02574044
159AHR_22903824_ChIP-Seq_MCF-7_Human1.01895405
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01674549
161LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01214652
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00838659
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.99716669
164TP53_16413492_ChIP-PET_HCT116_Human0.99701924
165FOXA1_25329375_ChIP-Seq_VCAP_Human0.99582308
166FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99582308
167ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98049886
168KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98015769
169AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97654619
170ISL1_27105846_Chip-Seq_CPCs_Mouse0.97083272
171NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97070578
172ESR1_20079471_ChIP-ChIP_T-47D_Human0.95352233
173ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95170664
174TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94644163
175STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93650134
176WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93331373
177SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92688158
178CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91798131
179NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90745070
180SCL_19346495_ChIP-Seq_HPC-7_Human0.90133550
181RING1B_27294783_Chip-Seq_ESCs_Mouse0.89697936
182NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89470502
183WT1_19549856_ChIP-ChIP_CCG9911_Human0.87759008
184RUNX1_27514584_Chip-Seq_MCF-7_Human0.87444104
185PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85985585
186KDM2B_26808549_Chip-Seq_JURKAT_Human0.85754602
187RING1B_27294783_Chip-Seq_NPCs_Mouse0.85694443
188FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85467194
189NOTCH1_21737748_ChIP-Seq_TLL_Human0.83870674
190SOX2_20726797_ChIP-Seq_SW620_Human0.83189296
191* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81913926
192* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81064348
193KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80994814
194ATF3_27146783_Chip-Seq_COLON_Human0.80819893
195PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80622122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.85352145
2MP0001879_abnormal_lymphatic_vessel5.80707559
3MP0005167_abnormal_blood-brain_barrier4.91930545
4MP0004084_abnormal_cardiac_muscle4.00316861
5MP0003828_pulmonary_edema3.54613997
6MP0004215_abnormal_myocardial_fiber3.54562522
7MP0003724_increased_susceptibility_to3.23190835
8MP0005670_abnormal_white_adipose2.98586243
9MP0004272_abnormal_basement_membrane2.93387281
10MP0004484_altered_response_of2.51157635
11MP0005330_cardiomyopathy2.50942077
12MP0002837_dystrophic_cardiac_calcinosis2.49113233
13MP0002127_abnormal_cardiovascular_syste2.45080948
14MP0005623_abnormal_meninges_morphology2.42588991
15MP0004036_abnormal_muscle_relaxation2.42412601
16MP0005551_abnormal_eye_electrophysiolog2.32993809
17MP0006138_congestive_heart_failure2.29794467
18MP0008775_abnormal_heart_ventricle2.23936658
19MP0004885_abnormal_endolymph2.18460924
20MP0004147_increased_porphyrin_level2.16629517
21MP0000013_abnormal_adipose_tissue2.14636999
22MP0006054_spinal_hemorrhage2.08292033
23MP0000751_myopathy2.04157975
24MP0002332_abnormal_exercise_endurance2.04005665
25MP0010630_abnormal_cardiac_muscle2.03138322
26MP0002972_abnormal_cardiac_muscle1.98667968
27MP0000750_abnormal_muscle_regeneration1.93830528
28MP0005385_cardiovascular_system_phenoty1.88284583
29MP0001544_abnormal_cardiovascular_syste1.88284583
30MP0001968_abnormal_touch/_nociception1.86911557
31MP0005165_increased_susceptibility_to1.83725878
32MP0003195_calcinosis1.83032940
33MP0001986_abnormal_taste_sensitivity1.82171700
34MP0001501_abnormal_sleep_pattern1.79577934
35MP0008877_abnormal_DNA_methylation1.78024311
36MP0000372_irregular_coat_pigmentation1.73259172
37MP0000749_muscle_degeneration1.70806158
38MP0004085_abnormal_heartbeat1.70619536
39MP0005253_abnormal_eye_physiology1.69906483
40MP0002736_abnormal_nociception_after1.65485521
41MP0005620_abnormal_muscle_contractility1.65037716
42MP0004510_myositis1.64417133
43MP0003646_muscle_fatigue1.63474504
44MP0004087_abnormal_muscle_fiber1.58419040
45MP0004130_abnormal_muscle_cell1.57132655
46MP0009379_abnormal_foot_pigmentation1.56371173
47MP0005171_absent_coat_pigmentation1.55877717
48MP0002638_abnormal_pupillary_reflex1.52547229
49MP0005409_darkened_coat_color1.49956126
50MP0003279_aneurysm1.45893269
51MP0002876_abnormal_thyroid_physiology1.44732399
52MP0008872_abnormal_physiological_respon1.43667116
53MP0009745_abnormal_behavioral_response1.43150698
54MP0000249_abnormal_blood_vessel1.43130890
55MP0000343_altered_response_to1.40865712
56MP0003137_abnormal_impulse_conducting1.34433951
57* MP0002925_abnormal_cardiovascular_devel1.31781420
58MP0009278_abnormal_bone_marrow1.29618104
59MP0001486_abnormal_startle_reflex1.28236434
60MP0004043_abnormal_pH_regulation1.27352406
61* MP0000767_abnormal_smooth_muscle1.26444875
62MP0005666_abnormal_adipose_tissue1.25598924
63MP0002272_abnormal_nervous_system1.25190723
64MP0000569_abnormal_digit_pigmentation1.21986007
65MP0006072_abnormal_retinal_apoptosis1.21668885
66MP0003011_delayed_dark_adaptation1.21598978
67MP0002106_abnormal_muscle_physiology1.21370909
68* MP0002128_abnormal_blood_circulation1.21294613
69MP0000266_abnormal_heart_morphology1.20414044
70MP0000003_abnormal_adipose_tissue1.18932035
71MP0003880_abnormal_central_pattern1.17797759
72MP0003566_abnormal_cell_adhesion1.17035285
73MP0005595_abnormal_vascular_smooth1.14845450
74MP0009046_muscle_twitch1.11941716
75MP0003045_fibrosis1.11546667
76MP0005084_abnormal_gallbladder_morpholo1.10377154
77MP0000465_gastrointestinal_hemorrhage1.10098574
78MP0004145_abnormal_muscle_electrophysio1.09078517
79MP0005375_adipose_tissue_phenotype1.08972993
80MP0004883_abnormal_blood_vessel1.08563323
81MP0003941_abnormal_skin_development1.06885822
82* MP0001614_abnormal_blood_vessel1.05828497
83MP0005410_abnormal_fertilization1.05504710
84MP0002269_muscular_atrophy1.03750794
85MP0005174_abnormal_tail_pigmentation1.02404981
86MP0008004_abnormal_stomach_pH1.02108404
87MP0005369_muscle_phenotype0.98384003
88MP0008875_abnormal_xenobiotic_pharmacok0.98274856
89MP0002735_abnormal_chemical_nociception0.97338573
90MP0001502_abnormal_circadian_rhythm0.96714948
91MP0000427_abnormal_hair_cycle0.95971918
92MP0002102_abnormal_ear_morphology0.95939075
93MP0001784_abnormal_fluid_regulation0.95346431
94MP0002933_joint_inflammation0.94944015
95MP0006276_abnormal_autonomic_nervous0.89390194
96MP0002064_seizures0.87545507
97MP0002088_abnormal_embryonic_growth/wei0.87013559
98MP0002572_abnormal_emotion/affect_behav0.86322489
99MP0005187_abnormal_penis_morphology0.85393998
100MP0004808_abnormal_hematopoietic_stem0.85320703
101MP0005164_abnormal_response_to0.84281627
102MP0003283_abnormal_digestive_organ0.83983383
103MP0003984_embryonic_growth_retardation0.83910057
104MP0005646_abnormal_pituitary_gland0.83659092
105MP0003136_yellow_coat_color0.82456597
106MP0005195_abnormal_posterior_eye0.82316975
107MP0002009_preneoplasia0.82146465
108MP0009780_abnormal_chondrocyte_physiolo0.81672893
109MP0000230_abnormal_systemic_arterial0.81573469
110MP0001970_abnormal_pain_threshold0.81160229
111MP0000759_abnormal_skeletal_muscle0.81133410
112MP0005365_abnormal_bile_salt0.81117090
113MP0002254_reproductive_system_inflammat0.79449249
114MP0002234_abnormal_pharynx_morphology0.79242702
115MP0003221_abnormal_cardiomyocyte_apopto0.78379229
116MP0001485_abnormal_pinna_reflex0.78286562
117MP0002086_abnormal_extraembryonic_tissu0.76942925
118MP0002733_abnormal_thermal_nociception0.76858175
119MP0003950_abnormal_plasma_membrane0.75982598
120MP0002160_abnormal_reproductive_system0.75029035
121MP0003300_gastrointestinal_ulcer0.74957925
122MP0005647_abnormal_sex_gland0.74615461
123MP0003122_maternal_imprinting0.74259856
124MP0003943_abnormal_hepatobiliary_system0.73485139
125MP0003718_maternal_effect0.73482212
126MP0002138_abnormal_hepatobiliary_system0.73414684
127MP0003567_abnormal_fetal_cardiomyocyte0.72875699
128MP0005319_abnormal_enzyme/_coenzyme0.70757128
129MP0003186_abnormal_redox_activity0.70070312
130MP0004133_heterotaxia0.70056789
131MP0005266_abnormal_metabolism0.68948439
132MP0009115_abnormal_fat_cell0.66609110
133MP0001672_abnormal_embryogenesis/_devel0.66219690
134MP0005380_embryogenesis_phenotype0.66219690
135MP0009764_decreased_sensitivity_to0.65642269
136MP0001851_eye_inflammation0.64764861
137MP0001915_intracranial_hemorrhage0.63113606
138MP0005391_vision/eye_phenotype0.61266677
139MP0002557_abnormal_social/conspecific_i0.61175496
140MP0003091_abnormal_cell_migration0.59591040
141MP0005397_hematopoietic_system_phenotyp0.58573524
142MP0001545_abnormal_hematopoietic_system0.58573524
143MP0003638_abnormal_response/metabolism_0.57108103
144MP0001873_stomach_inflammation0.56299696
145* MP0002295_abnormal_pulmonary_circulatio0.56189961
146MP0003303_peritoneal_inflammation0.54824957
147MP0000516_abnormal_urinary_system0.53635408
148MP0005367_renal/urinary_system_phenotyp0.53635408
149MP0008874_decreased_physiological_sensi0.51840248
150MP0009697_abnormal_copulation0.50735923
151MP0001853_heart_inflammation0.49269491
152MP0003705_abnormal_hypodermis_morpholog0.49028261

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)5.94213407
2Sudden death (HP:0001699)5.65241464
3Congenital stationary night blindness (HP:0007642)5.34521217
4Muscle fiber splitting (HP:0003555)5.26115932
5Atrial fibrillation (HP:0005110)4.79698457
6Polycythemia (HP:0001901)4.64484276
7Primary atrial arrhythmia (HP:0001692)4.47658937
8Supraventricular arrhythmia (HP:0005115)4.41270562
9Supraventricular tachycardia (HP:0004755)4.29498378
10Difficulty running (HP:0009046)4.27350937
11Nonimmune hydrops fetalis (HP:0001790)4.24836097
12Esophageal varix (HP:0002040)4.23301329
13Hematochezia (HP:0002573)4.10303184
14Absent hand (HP:0004050)4.08855443
15Hyporeflexia of lower limbs (HP:0002600)3.98404536
16Increased connective tissue (HP:0009025)3.84929266
17Congenital, generalized hypertrichosis (HP:0004540)3.80352833
18Exercise-induced muscle cramps (HP:0003710)3.73520140
19Lipoatrophy (HP:0100578)3.72489113
20Right ventricular cardiomyopathy (HP:0011663)3.70438121
21Pancreatic cysts (HP:0001737)3.63864438
22Molar tooth sign on MRI (HP:0002419)3.63483040
23Abnormality of midbrain morphology (HP:0002418)3.63483040
24Abnormality of the nasal mucosa (HP:0000433)3.60613976
25Hypochromic microcytic anemia (HP:0004840)3.58759015
26Hypoplasia of the fovea (HP:0007750)3.53441816
27Aplasia/Hypoplasia of the fovea (HP:0008060)3.53441816
28Adactyly (HP:0009776)3.49619834
29Lymphangioma (HP:0100764)3.48205745
30Hyperventilation (HP:0002883)3.45567066
31Syncope (HP:0001279)3.43687160
32Nephronophthisis (HP:0000090)3.43043548
33Difficulty climbing stairs (HP:0003551)3.38275670
34Hypoglycemic coma (HP:0001325)3.38063001
35Calf muscle hypertrophy (HP:0008981)3.37381194
36Hyperinsulinemic hypoglycemia (HP:0000825)3.32103917
37Pancreatic fibrosis (HP:0100732)3.31782987
38Distal lower limb muscle weakness (HP:0009053)3.26420528
39True hermaphroditism (HP:0010459)3.25745023
40Abnormality of the renal medulla (HP:0100957)3.18762284
41Hemiparesis (HP:0001269)3.16436232
42Type II lissencephaly (HP:0007260)3.16063169
43Atrioventricular block (HP:0001678)3.14955441
44Prolonged QT interval (HP:0001657)3.14616058
45Muscle hypertrophy of the lower extremities (HP:0008968)3.09895889
46Abnormality of the fovea (HP:0000493)3.09443100
47Dilated cardiomyopathy (HP:0001644)3.06918046
48Abnormality of the calf musculature (HP:0001430)3.04768104
49Scotoma (HP:0000575)3.04143097
50Abnormality of the renal cortex (HP:0011035)3.03850964
51Increased corneal curvature (HP:0100692)3.00708844
52Keratoconus (HP:0000563)3.00708844
53Testicular atrophy (HP:0000029)3.00419110
54Spontaneous hematomas (HP:0007420)2.99947091
55Myotonia (HP:0002486)2.96563045
56Tubular atrophy (HP:0000092)2.96403839
57Exercise-induced myalgia (HP:0003738)2.89955069
58Areflexia of lower limbs (HP:0002522)2.89877041
59EMG: myopathic abnormalities (HP:0003458)2.89593583
60Attenuation of retinal blood vessels (HP:0007843)2.85103610
61Myoglobinuria (HP:0002913)2.83914351
62Short hallux (HP:0010109)2.77142353
63Portal hypertension (HP:0001409)2.71256201
64Abnormal drinking behavior (HP:0030082)2.68777056
65Polydipsia (HP:0001959)2.68777056
66Mesangial abnormality (HP:0001966)2.67736452
67Venous insufficiency (HP:0005293)2.64690711
68Aplasia/Hypoplasia of the macula (HP:0008059)2.63376809
69Palpitations (HP:0001962)2.60632763
70Broad metatarsal (HP:0001783)2.59969774
71Ventricular arrhythmia (HP:0004308)2.58542463
72Absent toe (HP:0010760)2.58470407
73Abnormality of macular pigmentation (HP:0008002)2.58304607
74Aplasia/Hypoplasia of the hallux (HP:0008362)2.58243637
75Abnormal rod and cone electroretinograms (HP:0008323)2.57449969
76Abolished electroretinogram (ERG) (HP:0000550)2.56266712
77Heart block (HP:0012722)2.53542390
78Abnormality of alanine metabolism (HP:0010916)2.51814228
79Hyperalaninemia (HP:0003348)2.51814228
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51814228
81Congenital hepatic fibrosis (HP:0002612)2.51206001
82Cerebral hemorrhage (HP:0001342)2.50550675
83Pancreatic islet-cell hyperplasia (HP:0004510)2.47612555
84Muscle fibrillation (HP:0010546)2.47301115
85Inability to walk (HP:0002540)2.46920602
86Abnormality of the hepatic vasculature (HP:0006707)2.46540798
87Venous abnormality (HP:0002624)2.46294143
88Aplasia/Hypoplasia affecting the retina (HP:0008061)2.45205144
89Abnormal EKG (HP:0003115)2.45060503
90Muscle stiffness (HP:0003552)2.44102456
91Broad-based gait (HP:0002136)2.41791730
92Absent speech (HP:0001344)2.41021471
93Cerebral aneurysm (HP:0004944)2.40898851
94Abnormal atrioventricular conduction (HP:0005150)2.40443707
95Bulbous nose (HP:0000414)2.39077686
96Increased variability in muscle fiber diameter (HP:0003557)2.38213253
97Bundle branch block (HP:0011710)2.38107016
98Lymphedema (HP:0001004)2.37317059
99Ventricular fibrillation (HP:0001663)2.35045800
100Cystic liver disease (HP:0006706)2.32416749
101Decreased central vision (HP:0007663)2.30914802
102Hypotrichosis (HP:0001006)2.30553059
103Gaze-evoked nystagmus (HP:0000640)2.30436514
104Asymmetric septal hypertrophy (HP:0001670)2.29984275
105Focal motor seizures (HP:0011153)2.28779852
106Focal seizures (HP:0007359)2.28007021
107Progressive inability to walk (HP:0002505)2.27946003
108Subaortic stenosis (HP:0001682)2.27067654
109Abnormality of the left ventricular outflow tract (HP:0011103)2.27067654
110Large for gestational age (HP:0001520)2.27064751
111Visceral angiomatosis (HP:0100761)2.26508427
112Pulmonary artery stenosis (HP:0004415)2.26018651
113Medial flaring of the eyebrow (HP:0010747)2.25479476
114Polyuria (HP:0000103)2.20925635
115Abnormality of skeletal muscle fiber size (HP:0012084)2.20831036
116Hypoplastic ischia (HP:0003175)2.19767302
117Occipital encephalocele (HP:0002085)2.17514292
118Shawl scrotum (HP:0000049)2.15233182
119Acanthosis nigricans (HP:0000956)2.15168737
120Hemiplegia (HP:0002301)2.14864418
121Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14514287
122Porencephaly (HP:0002132)2.13931617
123Rhabdomyolysis (HP:0003201)2.10891030
124Chronic hepatic failure (HP:0100626)2.07794877
125Chorioretinal atrophy (HP:0000533)2.07520285
126Congenital sensorineural hearing impairment (HP:0008527)2.07268574
127Disproportionate short-trunk short stature (HP:0003521)2.04159652
128Hemangiomatosis (HP:0007461)2.03973864
129Febrile seizures (HP:0002373)2.03154582
130Enlarged penis (HP:0000040)2.02914627
131Pendular nystagmus (HP:0012043)2.02220563
132Hypothermia (HP:0002045)2.00650736
133EMG: neuropathic changes (HP:0003445)1.98463627
134Cerebellar dysplasia (HP:0007033)1.98121954
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.97690819
136Delayed CNS myelination (HP:0002188)1.97397096
137Lissencephaly (HP:0001339)1.97336882
138Abnormality of the axillary hair (HP:0100134)1.96501061
139Abnormality of secondary sexual hair (HP:0009888)1.96501061
140Facial diplegia (HP:0001349)1.93695048
141Stroke (HP:0001297)1.88825475
142Abnormality of the ischium (HP:0003174)1.88398118
143Hypoglycemic seizures (HP:0002173)1.87971676
144Ketoacidosis (HP:0001993)1.87787505
145Left ventricular hypertrophy (HP:0001712)1.86968367
146Conjunctival telangiectasia (HP:0000524)1.86821879
147Fair hair (HP:0002286)1.85815424
148Skull defect (HP:0001362)1.85577054
149Sclerocornea (HP:0000647)1.84603160
150Widely spaced teeth (HP:0000687)1.84083520
151Aneurysm (HP:0002617)1.84005937
152Reduced subcutaneous adipose tissue (HP:0003758)1.83935892
153Microcytic anemia (HP:0001935)1.82138645
154Rapidly progressive (HP:0003678)1.82110084
155Albinism (HP:0001022)1.81376942
156Atonic seizures (HP:0010819)1.80639814
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80233462
158Muscular dystrophy (HP:0003560)1.78520501
159Stomach cancer (HP:0012126)1.77801971
160Stage 5 chronic kidney disease (HP:0003774)1.77781474
161Distal lower limb amyotrophy (HP:0008944)1.77210673
162Renal cortical cysts (HP:0000803)1.76804352
163Abnormal urine output (HP:0012590)1.76615052
164Insulin-resistant diabetes mellitus (HP:0000831)1.76587657
165Growth hormone excess (HP:0000845)1.76580647
166Pachygyria (HP:0001302)1.74990243
167Preaxial foot polydactyly (HP:0001841)1.74085449
168Hypoproteinemia (HP:0003075)1.72226122
169Hypoplastic left heart (HP:0004383)1.72178966
170Decreased circulating renin level (HP:0003351)1.71941142
171Abnormality of the vitreous humor (HP:0004327)1.71144125
172Ileus (HP:0002595)1.70326834
173Exotropia (HP:0000577)1.69457875
174Wrist flexion contracture (HP:0001239)1.69277617
175Protruding tongue (HP:0010808)1.68752088
176Generalized hypopigmentation of hair (HP:0011358)1.68543113
177Type 2 muscle fiber atrophy (HP:0003554)1.67534649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR8.87827144
2TIE17.30573075
3FRK4.41660334
4TGFBR23.52028901
5MAP4K22.75200773
6TGFBR12.72937040
7MYLK2.55876552
8GRK12.35247764
9ADRBK22.10939762
10ACVR1B2.03824585
11EPHA22.03364938
12PDK22.02017832
13BCKDK1.98471411
14TTN1.94506475
15MAPK151.63361567
16PTK2B1.62303938
17PRKG21.56152926
18INSRR1.53872963
19BMPR1B1.52577253
20STK391.51139688
21PHKG11.50851222
22PHKG21.50851222
23AKT31.50317518
24WNK31.47936267
25MAPK131.47691677
26ERN11.42161317
27NUAK11.34603065
28ZAK1.31897402
29MAPKAPK31.31176494
30NTRK31.25127948
31MAPK121.24666521
32RIPK11.23003753
33DAPK21.22132658
34MAP3K111.20299557
35WNK41.20198414
36CDK121.17302731
37MARK11.16288905
38TEC1.15240518
39MAP3K31.13995655
40PRKAA21.13616805
41CASK1.12774510
42MAP2K31.05240866
43OXSR11.04197818
44DMPK1.03531392
45MATK1.03264641
46FES0.98232681
47PRKCE0.97156390
48LMTK20.96011377
49CAMKK20.95355660
50ADRBK10.94092253
51EPHB20.89465731
52MAPK70.88951195
53PLK20.88545760
54CDK90.84922592
55NLK0.84403487
56FER0.83273056
57MAP2K20.81502748
58CAMK40.81233702
59PKN20.78823488
60PRKD10.77326297
61RPS6KB20.76568493
62MAP3K40.75667082
63OBSCN0.75479037
64TBK10.73575530
65TNIK0.73574779
66EPHB10.71396259
67EPHA30.69544062
68PAK40.69226839
69DAPK30.66669295
70LRRK20.66343352
71EPHA40.65367052
72MUSK0.65152526
73STK38L0.65057035
74LATS20.64091702
75ALK0.63921836
76TAOK30.63234010
77CSNK1G10.62977491
78PRKCG0.61198648
79PRKD20.59991270
80PTK60.59632266
81JAK10.58614828
82IRAK30.58370509
83TNK20.58246551
84IRAK10.57416725
85TAF10.56072726
86DYRK30.55746514
87PIK3CG0.54351900
88GRK50.54293049
89TLK10.53110638
90TRIM280.51384622
91PAK20.50751417
92FLT30.50143136
93WEE10.49950502
94TAOK10.49337634
95CAMK10.48620646
96PAK30.48048806
97TRIB30.46176042
98IGF1R0.45806848
99PDK30.45372534
100PDK40.45372534
101MTOR0.45002892
102ICK0.44998396
103STK110.44375306
104BRSK20.44323532
105MAP3K50.44282454
106PKN10.43629670
107ITK0.43482527
108MET0.43247050
109PIK3CA0.42568166
110FGFR20.42117780
111MAPK40.41556901
112AKT20.41415342
113TSSK60.41177420
114CSNK1G20.41012479
115ROCK10.41002216
116IKBKB0.40332789
117CSNK1A1L0.39842312
118PRKD30.38904142
119MAP3K120.38892442
120GRK70.38800540
121PAK60.38608540
122MAP3K70.37845350
123CSK0.37649080
124CAMK2D0.36829219
125ERBB40.36736268
126FGFR40.36407295
127MAPKAPK50.36205749
128PRKG10.35371665
129ILK0.35353830
130PRKAA10.35345572
131CDC42BPA0.34857259
132EIF2AK30.34781982
133CAMK2A0.34434741
134GSK3A0.34369608
135PDGFRA0.33614283
136SIK10.33515534
137CSNK1G30.33393722
138PRKACA0.32925519
139SIK20.32651386
140MAP3K60.31867079
141PRKCZ0.29546259
142DYRK1B0.29436511
143MAP3K140.28824142
144MST40.28644581
145TYRO30.28182014
146CSNK1A10.27813093
147SIK30.27742364
148PRKCA0.26461703
149TXK0.25389282
150TRPM70.25357712
151MARK20.24930954
152JAK20.24037145
153CHUK0.23412120
154SRC0.23191368
155KIT0.22341013
156PIM20.22253866
157STK100.21602985
158PNCK0.21259454
159PTK20.20465409
160MAP2K10.18972072
161IKBKE0.18927302
162INSR0.18631155
163PINK10.18254641

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.20705551
2Phototransduction_Homo sapiens_hsa047443.02797709
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.76509292
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63618480
5Cardiac muscle contraction_Homo sapiens_hsa042602.46645432
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40347782
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33380490
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30655996
9Butanoate metabolism_Homo sapiens_hsa006502.13043014
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08653936
11Propanoate metabolism_Homo sapiens_hsa006402.08630563
12Linoleic acid metabolism_Homo sapiens_hsa005912.08396133
13Adherens junction_Homo sapiens_hsa045202.02405066
14African trypanosomiasis_Homo sapiens_hsa051431.95199580
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93857050
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92975745
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.88715134
18Focal adhesion_Homo sapiens_hsa045101.85866852
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84190707
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84032146
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.83496073
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81641011
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.76279403
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.65776188
25Ribosome_Homo sapiens_hsa030101.65400575
26Insulin secretion_Homo sapiens_hsa049111.65065260
27Ether lipid metabolism_Homo sapiens_hsa005651.63271631
28Rap1 signaling pathway_Homo sapiens_hsa040151.62171976
29Arginine biosynthesis_Homo sapiens_hsa002201.62072378
30Morphine addiction_Homo sapiens_hsa050321.59214621
31Bile secretion_Homo sapiens_hsa049761.56990702
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56307796
33HIF-1 signaling pathway_Homo sapiens_hsa040661.55842365
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55108356
35Tight junction_Homo sapiens_hsa045301.45856001
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45099094
37Notch signaling pathway_Homo sapiens_hsa043301.44359646
38Malaria_Homo sapiens_hsa051441.43857677
39PPAR signaling pathway_Homo sapiens_hsa033201.43847945
40Nicotine addiction_Homo sapiens_hsa050331.43821158
41Ovarian steroidogenesis_Homo sapiens_hsa049131.42313618
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41295653
43Circadian rhythm_Homo sapiens_hsa047101.37721916
44Olfactory transduction_Homo sapiens_hsa047401.37644234
45Circadian entrainment_Homo sapiens_hsa047131.35691690
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34748971
47Insulin resistance_Homo sapiens_hsa049311.33302917
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.32813355
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.30736108
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24069425
51Glutamatergic synapse_Homo sapiens_hsa047241.20647592
52Vitamin digestion and absorption_Homo sapiens_hsa049771.19275592
53Viral myocarditis_Homo sapiens_hsa054161.19079554
54Tryptophan metabolism_Homo sapiens_hsa003801.18564211
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18427153
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18144223
57ECM-receptor interaction_Homo sapiens_hsa045121.16268076
58Fatty acid degradation_Homo sapiens_hsa000711.16032392
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15204851
60ABC transporters_Homo sapiens_hsa020101.14284478
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.11938452
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10647510
63Basal transcription factors_Homo sapiens_hsa030221.09773698
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08256807
65Platelet activation_Homo sapiens_hsa046111.07639637
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07604643
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06966665
68PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04064205
69VEGF signaling pathway_Homo sapiens_hsa043701.02533470
70Parkinsons disease_Homo sapiens_hsa050121.02136936
71Melanogenesis_Homo sapiens_hsa049161.00144708
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.99824015
73Oxytocin signaling pathway_Homo sapiens_hsa049210.99347540
74Caffeine metabolism_Homo sapiens_hsa002320.98561290
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97116529
76beta-Alanine metabolism_Homo sapiens_hsa004100.96184858
77Selenocompound metabolism_Homo sapiens_hsa004500.94709518
78Pathways in cancer_Homo sapiens_hsa052000.94425549
79Galactose metabolism_Homo sapiens_hsa000520.93702165
80Protein export_Homo sapiens_hsa030600.92830551
81Regulation of autophagy_Homo sapiens_hsa041400.92033836
82Proteoglycans in cancer_Homo sapiens_hsa052050.89825592
83Basal cell carcinoma_Homo sapiens_hsa052170.89707578
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89108298
85Chemical carcinogenesis_Homo sapiens_hsa052040.88681336
86Mineral absorption_Homo sapiens_hsa049780.88521268
87Ras signaling pathway_Homo sapiens_hsa040140.86611175
88Hippo signaling pathway_Homo sapiens_hsa043900.86069482
89Dorso-ventral axis formation_Homo sapiens_hsa043200.85895742
90Glycerolipid metabolism_Homo sapiens_hsa005610.85800612
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85368691
92Arachidonic acid metabolism_Homo sapiens_hsa005900.85287109
93Small cell lung cancer_Homo sapiens_hsa052220.84192574
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82144560
95Huntingtons disease_Homo sapiens_hsa050160.80805604
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.80658158
97Gap junction_Homo sapiens_hsa045400.80114205
98Carbon metabolism_Homo sapiens_hsa012000.79721974
99AMPK signaling pathway_Homo sapiens_hsa041520.79688300
100Estrogen signaling pathway_Homo sapiens_hsa049150.79685092
101Toxoplasmosis_Homo sapiens_hsa051450.79523255
102Fat digestion and absorption_Homo sapiens_hsa049750.78888892
103Histidine metabolism_Homo sapiens_hsa003400.78767111
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.78415709
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76950284
106Arginine and proline metabolism_Homo sapiens_hsa003300.76778252
107Sulfur metabolism_Homo sapiens_hsa009200.75666191
108Fructose and mannose metabolism_Homo sapiens_hsa000510.74924483
109Amoebiasis_Homo sapiens_hsa051460.73988883
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73812281
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.73192926
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72448123
113Glucagon signaling pathway_Homo sapiens_hsa049220.71565738
114Fatty acid metabolism_Homo sapiens_hsa012120.70939763
115Fatty acid elongation_Homo sapiens_hsa000620.70145306
116Cocaine addiction_Homo sapiens_hsa050300.68230804
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67862578
118Peroxisome_Homo sapiens_hsa041460.65945771
119TGF-beta signaling pathway_Homo sapiens_hsa043500.65659034
120Insulin signaling pathway_Homo sapiens_hsa049100.65470737
121Retinol metabolism_Homo sapiens_hsa008300.65187896
122Homologous recombination_Homo sapiens_hsa034400.64937613
123Nitrogen metabolism_Homo sapiens_hsa009100.64563987
124Renin secretion_Homo sapiens_hsa049240.64459022
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63449901
126RNA polymerase_Homo sapiens_hsa030200.63419582
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63002368
128Complement and coagulation cascades_Homo sapiens_hsa046100.62868766
129GnRH signaling pathway_Homo sapiens_hsa049120.61954225
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61241576
131Serotonergic synapse_Homo sapiens_hsa047260.60253388
132Amphetamine addiction_Homo sapiens_hsa050310.58935026
133Sphingolipid metabolism_Homo sapiens_hsa006000.58832779
134Fanconi anemia pathway_Homo sapiens_hsa034600.58556040
135Calcium signaling pathway_Homo sapiens_hsa040200.58178154
136cAMP signaling pathway_Homo sapiens_hsa040240.57592226
137Dopaminergic synapse_Homo sapiens_hsa047280.56391452
138Long-term depression_Homo sapiens_hsa047300.55832121
139Oxidative phosphorylation_Homo sapiens_hsa001900.55510776
140Hedgehog signaling pathway_Homo sapiens_hsa043400.54589544
141Thyroid hormone synthesis_Homo sapiens_hsa049180.54079621
142MicroRNAs in cancer_Homo sapiens_hsa052060.53719581
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52697395
144MAPK signaling pathway_Homo sapiens_hsa040100.52622702
145Renal cell carcinoma_Homo sapiens_hsa052110.52484112
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52014174
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51655426
148Collecting duct acid secretion_Homo sapiens_hsa049660.51527423
149TNF signaling pathway_Homo sapiens_hsa046680.51350435
150Alzheimers disease_Homo sapiens_hsa050100.49618793
151HTLV-I infection_Homo sapiens_hsa051660.47157120
152Gastric acid secretion_Homo sapiens_hsa049710.46782951
153GABAergic synapse_Homo sapiens_hsa047270.45149372
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44279921
155Salivary secretion_Homo sapiens_hsa049700.42708857
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42138811
157Folate biosynthesis_Homo sapiens_hsa007900.41841006
158Taste transduction_Homo sapiens_hsa047420.40746120
159Cholinergic synapse_Homo sapiens_hsa047250.40329432
160Axon guidance_Homo sapiens_hsa043600.40306313
161Wnt signaling pathway_Homo sapiens_hsa043100.40050198

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