GPR42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)5.77210257
2regulation of chronic inflammatory response (GO:0002676)5.43600211
3regulation of vitamin D biosynthetic process (GO:0060556)5.37712812
4type I interferon signaling pathway (GO:0060337)5.06518740
5cellular response to type I interferon (GO:0071357)5.06518740
6response to type I interferon (GO:0034340)4.98459196
7negative regulation of interleukin-12 production (GO:0032695)4.85103256
8regulation of cytokine secretion involved in immune response (GO:0002739)4.68914348
9NIK/NF-kappaB signaling (GO:0038061)4.63492122
10regulation of interferon-alpha production (GO:0032647)4.59956270
11response to peptidoglycan (GO:0032494)4.35103650
12regulation of vitamin metabolic process (GO:0030656)4.20089036
13branching involved in labyrinthine layer morphogenesis (GO:0060670)4.15395819
14positive regulation of heat generation (GO:0031652)4.09679674
15defense response to protozoan (GO:0042832)3.98966933
16regulation of fever generation (GO:0031620)3.93101620
17response to protozoan (GO:0001562)3.88716703
18regulation of chemokine biosynthetic process (GO:0045073)3.86940871
19positive regulation of chemokine biosynthetic process (GO:0045080)3.86094786
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81486871
21macrophage activation involved in immune response (GO:0002281)3.79095214
22myeloid dendritic cell differentiation (GO:0043011)3.75205058
23negative regulation of cytokine production involved in immune response (GO:0002719)3.74970058
24negative regulation of viral genome replication (GO:0045071)3.72701418
25positive regulation of acute inflammatory response (GO:0002675)3.72163186
26immunoglobulin mediated immune response (GO:0016064)3.68072244
27interferon-gamma-mediated signaling pathway (GO:0060333)3.65579973
28regulation of norepinephrine secretion (GO:0014061)3.63418103
29positive regulation of interferon-alpha production (GO:0032727)3.63234936
30neutrophil activation involved in immune response (GO:0002283)3.61822237
31germinal center formation (GO:0002467)3.56574947
32regulation of podosome assembly (GO:0071801)3.55216234
33negative regulation of nitric oxide biosynthetic process (GO:0045019)3.52452163
34regulation of immunoglobulin secretion (GO:0051023)3.51872156
35positive regulation of type 2 immune response (GO:0002830)3.45716563
36positive regulation of gamma-delta T cell activation (GO:0046645)3.43432342
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.42994272
38regulation of T-helper cell differentiation (GO:0045622)3.39035631
39T-helper 1 type immune response (GO:0042088)3.38674665
40negative regulation of myeloid cell apoptotic process (GO:0033033)3.34188502
41positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.34134018
42activation of MAPKKK activity (GO:0000185)3.34015900
43regulation of interleukin-8 biosynthetic process (GO:0045414)3.33150260
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32754687
45positive regulation of natural killer cell differentiation (GO:0032825)3.30336408
46negative regulation of amino acid transport (GO:0051956)3.28466002
47regulation of membrane protein ectodomain proteolysis (GO:0051043)3.27699396
48regulation of nitric oxide biosynthetic process (GO:0045428)3.25610563
49regulation of interleukin-12 production (GO:0032655)3.25312655
50myeloid dendritic cell activation (GO:0001773)3.24412109
51regulation of T-helper 2 cell differentiation (GO:0045628)3.24122166
52regulation of type I interferon-mediated signaling pathway (GO:0060338)3.24087038
53granulocyte activation (GO:0036230)3.22829529
54oligosaccharide catabolic process (GO:0009313)3.21913463
55positive regulation of natural killer cell activation (GO:0032816)3.21389409
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.19926335
57positive regulation of nitric oxide biosynthetic process (GO:0045429)3.18402343
58regulation of type 2 immune response (GO:0002828)3.16403326
59regulation of mononuclear cell migration (GO:0071675)3.13430413
60negative regulation of growth of symbiont in host (GO:0044130)3.12066117
61negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.12066117
62modulation of growth of symbiont involved in interaction with host (GO:0044144)3.12066117
63regulation of growth of symbiont in host (GO:0044126)3.12066117
64positive regulation of antigen processing and presentation (GO:0002579)3.10921567
65regulation of heat generation (GO:0031650)3.09645136
66positive regulation of NF-kappaB import into nucleus (GO:0042346)3.08034060
67positive regulation of defense response to virus by host (GO:0002230)3.07239718
68monocyte chemotaxis (GO:0002548)3.06346996
69cellular response to lipopolysaccharide (GO:0071222)3.04995265
70positive regulation of lymphocyte apoptotic process (GO:0070230)3.03596641
71negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.00580116
72negative regulation of production of molecular mediator of immune response (GO:0002701)3.00305376
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00029293
74regulation of antigen processing and presentation (GO:0002577)2.99366641
75positive regulation of interferon-beta production (GO:0032728)2.98498377
76cellular response to molecule of bacterial origin (GO:0071219)2.96935124
77regulation of interferon-beta biosynthetic process (GO:0045357)2.96626486
78regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.96603776
79regulation of natural killer cell activation (GO:0032814)2.96344576
80dendritic cell differentiation (GO:0097028)2.94668017
81positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.94150286
82negative regulation of type I interferon production (GO:0032480)2.94063003
83regulation of heterotypic cell-cell adhesion (GO:0034114)2.93747177
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.93132028
85positive regulation of T-helper cell differentiation (GO:0045624)2.92814912
86cellular response to interferon-gamma (GO:0071346)2.92318423
87positive regulation of interleukin-6 production (GO:0032755)2.91792969
88positive regulation of interleukin-12 production (GO:0032735)2.90331365
89negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86660515
90regulation of inflammatory response to antigenic stimulus (GO:0002861)2.84924419
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.83014713
92regulation of T-helper 1 type immune response (GO:0002825)2.82380981
93response to interferon-gamma (GO:0034341)2.80366582
94regulation of RIG-I signaling pathway (GO:0039535)2.80123721
95regulation of NF-kappaB import into nucleus (GO:0042345)2.80053036
96response to muramyl dipeptide (GO:0032495)2.77423020
97mature B cell differentiation involved in immune response (GO:0002313)2.77254389
98regulation of cytokine production involved in immune response (GO:0002718)2.77218362
99JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77182507
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.75690714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.68431645
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.70967451
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.70120452
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.33297239
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.05531484
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.97342911
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.81576404
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.35647557
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23481856
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17874865
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.01038702
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94891982
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.93449454
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82726650
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74757328
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59922634
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55579531
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20765215
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11975991
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05609161
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.02759152
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97451232
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93327308
24VDR_24787735_ChIP-Seq_THP-1_Human1.86636799
25VDR_24763502_ChIP-Seq_THP-1_Human1.85952760
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79852674
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71694763
28SPI1_23127762_ChIP-Seq_K562_Human1.71218645
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65319714
30SPI1_23547873_ChIP-Seq_NB4_Human1.64494086
31VDR_21846776_ChIP-Seq_THP-1_Human1.62514679
32SCL_19346495_ChIP-Seq_HPC-7_Human1.61964548
33RUNX_20019798_ChIP-Seq_JUKART_Human1.60367443
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54665120
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54571691
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53469486
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52626919
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46916982
39MAF_26560356_Chip-Seq_TH1_Human1.46346973
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45275865
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41106880
42GATA1_22025678_ChIP-Seq_K562_Human1.40391789
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39965993
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38920297
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38597531
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38152671
47MYB_26560356_Chip-Seq_TH2_Human1.36430335
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30478336
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.29938305
50SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28202739
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.26102163
52STAT1_20625510_ChIP-Seq_HELA_Human1.22504156
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21945969
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21864512
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20517355
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20149993
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17193834
58GATA3_26560356_Chip-Seq_TH2_Human1.15357668
59UTX_26944678_Chip-Seq_JUKART_Human1.11298913
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10565815
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.10071523
62MYB_26560356_Chip-Seq_TH1_Human1.08916267
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08857640
64EGR1_19032775_ChIP-ChIP_M12_Human1.08836196
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07844927
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07226383
67PU_27001747_Chip-Seq_BMDM_Mouse1.06934177
68GATA1_19941826_ChIP-Seq_K562_Human1.06675795
69MAF_26560356_Chip-Seq_TH2_Human1.05418736
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.03663082
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00791315
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00791315
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00791315
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00162544
75KDM2B_26808549_Chip-Seq_DND41_Human0.96868400
76LXR_22292898_ChIP-Seq_THP-1_Human0.95907992
77GATA1_19941827_ChIP-Seq_MEL_Mouse0.93664854
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93105456
79GATA3_27048872_Chip-Seq_THYMUS_Human0.92962887
80TCF7_22412390_ChIP-Seq_EML_Mouse0.92830258
81RXR_22158963_ChIP-Seq_LIVER_Mouse0.89012772
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85790128
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.85495544
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84791511
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84039919
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83361235
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83037880
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79842184
89BCOR_27268052_Chip-Seq_Bcells_Human0.79336670
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79153538
91BCL6_27268052_Chip-Seq_Bcells_Human0.78303333
92TP63_17297297_ChIP-ChIP_HaCaT_Human0.78287836
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77153298
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76790541
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.76238603
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75414011
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75234469
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75057242
99LXR_22158963_ChIP-Seq_LIVER_Mouse0.72259695
100SOX2_20726797_ChIP-Seq_SW620_Human0.71483643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.07027879
2MP0003724_increased_susceptibility_to4.42179205
3MP0006082_CNS_inflammation3.70693623
4MP0004510_myositis3.52042713
5MP0009785_altered_susceptibility_to3.47998634
6MP0002148_abnormal_hypersensitivity_rea3.44191262
7MP0003436_decreased_susceptibility_to3.32739900
8MP0001835_abnormal_antigen_presentation3.13097893
9MP0005000_abnormal_immune_tolerance2.78789478
10MP0005058_abnormal_lysosome_morphology2.73549616
11MP0001790_abnormal_immune_system2.67814800
12MP0005387_immune_system_phenotype2.67814800
13MP0003300_gastrointestinal_ulcer2.63820374
14MP0002139_abnormal_hepatobiliary_system2.62429698
15MP0005671_abnormal_response_to2.56443191
16MP0005025_abnormal_response_to2.52840733
17MP0002419_abnormal_innate_immunity2.37490026
18MP0009764_decreased_sensitivity_to2.32293715
19MP0008004_abnormal_stomach_pH2.30896347
20MP0002254_reproductive_system_inflammat2.22481864
21MP0003075_altered_response_to2.16479278
22MP0002723_abnormal_immune_serum2.14284968
23MP0001533_abnormal_skeleton_physiology2.13051433
24MP0002452_abnormal_antigen_presenting2.02378180
25MP0001800_abnormal_humoral_immune2.02280492
26MP0003172_abnormal_lysosome_physiology2.00253385
27MP0009278_abnormal_bone_marrow1.91896818
28MP0002138_abnormal_hepatobiliary_system1.90738867
29MP0004947_skin_inflammation1.89688830
30MP0002332_abnormal_exercise_endurance1.84899684
31MP0010155_abnormal_intestine_physiology1.81053295
32MP0001845_abnormal_inflammatory_respons1.80894889
33MP0001819_abnormal_immune_cell1.71508684
34MP0002420_abnormal_adaptive_immunity1.70451927
35MP0003806_abnormal_nucleotide_metabolis1.69868281
36MP0005451_abnormal_body_composition1.68968559
37MP0001853_heart_inflammation1.62843446
38MP0008469_abnormal_protein_level1.62446485
39MP0005397_hematopoietic_system_phenotyp1.62295590
40MP0001545_abnormal_hematopoietic_system1.62295590
41MP0002405_respiratory_system_inflammati1.60997241
42MP0009840_abnormal_foam_cell1.59393589
43MP0006054_spinal_hemorrhage1.55472290
44MP0003453_abnormal_keratinocyte_physiol1.52443163
45MP0000343_altered_response_to1.50776602
46MP0000685_abnormal_immune_system1.50308456
47MP0005167_abnormal_blood-brain_barrier1.49040021
48MP0005310_abnormal_salivary_gland1.45278258
49MP0003195_calcinosis1.44094723
50MP0009333_abnormal_splenocyte_physiolog1.32927028
51MP0005166_decreased_susceptibility_to1.30830239
52MP0005464_abnormal_platelet_physiology1.29219964
53MP0003448_altered_tumor_morphology1.28881041
54MP0003690_abnormal_glial_cell1.26375794
55MP0001501_abnormal_sleep_pattern1.20472659
56MP0000858_altered_metastatic_potential1.19798425
57MP0000716_abnormal_immune_system1.19636484
58MP0000604_amyloidosis1.18760279
59MP0005666_abnormal_adipose_tissue1.10856190
60MP0001542_abnormal_bone_strength1.02167674
61MP0009763_increased_sensitivity_to0.99455870
62MP0002398_abnormal_bone_marrow0.99194933
63MP0002998_abnormal_bone_remodeling0.99105721
64MP0005164_abnormal_response_to0.97955011
65MP0005165_increased_susceptibility_to0.90861144
66MP0005535_abnormal_body_temperature0.87977320
67MP0002429_abnormal_blood_cell0.87855377
68MP0000689_abnormal_spleen_morphology0.87153886
69MP0005390_skeleton_phenotype0.85645646
70MP0004883_abnormal_blood_vessel0.85465651
71MP0003191_abnormal_cellular_cholesterol0.84630841
72MP0003656_abnormal_erythrocyte_physiolo0.83984883
73MP0001663_abnormal_digestive_system0.83323891
74MP0002722_abnormal_immune_system0.81497434
75MP0010307_abnormal_tumor_latency0.81298903
76MP0003646_muscle_fatigue0.80502654
77MP0003868_abnormal_feces_composition0.79352365
78MP0009765_abnormal_xenobiotic_induced0.78673449
79MP0002693_abnormal_pancreas_physiology0.76164343
80MP0003091_abnormal_cell_migration0.74664520
81MP0003879_abnormal_hair_cell0.72680929
82MP0001764_abnormal_homeostasis0.72473369
83MP0005266_abnormal_metabolism0.72189637
84MP0002933_joint_inflammation0.71678160
85MP0008874_decreased_physiological_sensi0.70912423
86MP0002837_dystrophic_cardiac_calcinosis0.69633949
87MP0003763_abnormal_thymus_physiology0.67690923
88MP0005448_abnormal_energy_balance0.63324057
89MP0005647_abnormal_sex_gland0.62232839
90MP0005375_adipose_tissue_phenotype0.62120604
91MP0001919_abnormal_reproductive_system0.59850786
92MP0000249_abnormal_blood_vessel0.54837368
93MP0005334_abnormal_fat_pad0.54293558
94MP0004808_abnormal_hematopoietic_stem0.54256670
95MP0005023_abnormal_wound_healing0.53987501
96MP0003279_aneurysm0.53885093
97MP0000920_abnormal_myelination0.53324279
98MP0003183_abnormal_peptide_metabolism0.52528688
99MP0000371_diluted_coat_color0.52437611
100MP0003795_abnormal_bone_structure0.51129111

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.16251037
2Abnormality of liposaccharide metabolism (HP:0010968)6.16251037
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.16251037
4Retrobulbar optic neuritis (HP:0100654)5.97216506
5Optic neuritis (HP:0100653)5.97216506
6Orchitis (HP:0100796)5.82138894
7Stomatitis (HP:0010280)5.26876301
8Myositis (HP:0100614)5.14246618
9Systemic lupus erythematosus (HP:0002725)4.68884819
10Abnormality of macrophages (HP:0004311)4.59665734
11Nuclear cataract (HP:0100018)4.49096588
12Keratoconjunctivitis sicca (HP:0001097)4.45244015
13Loss of speech (HP:0002371)4.43552317
14Disinhibition (HP:0000734)4.24161822
15Recurrent bacterial skin infections (HP:0005406)4.17127076
16Autoimmune thrombocytopenia (HP:0001973)4.14535791
17Keratoconjunctivitis (HP:0001096)4.10175379
18Vacuolated lymphocytes (HP:0001922)4.04241877
19Recurrent abscess formation (HP:0002722)3.96057437
20Eczematoid dermatitis (HP:0000976)3.93137723
21Dysostosis multiplex (HP:0000943)3.87237129
22Mutism (HP:0002300)3.71703644
23Increased cerebral lipofuscin (HP:0011813)3.58807033
24Mediastinal lymphadenopathy (HP:0100721)3.44141616
25Increased IgM level (HP:0003496)3.41833385
26Interstitial pulmonary disease (HP:0006530)3.22747005
27Elevated erythrocyte sedimentation rate (HP:0003565)3.15106629
28Abnormality of polysaccharide metabolism (HP:0011012)3.14698793
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.14698793
30Abnormality of mucopolysaccharide metabolism (HP:0011020)3.14698793
31Gangrene (HP:0100758)3.12046019
32Hematochezia (HP:0002573)3.08891491
33Parakeratosis (HP:0001036)3.05230368
34Pulmonary infiltrates (HP:0002113)3.03596848
35Abnormality of lateral ventricle (HP:0030047)3.03272417
36Recurrent gram-negative bacterial infections (HP:0005420)2.86778643
37Glomerulonephritis (HP:0000099)2.83467646
38Vasculitis (HP:0002633)2.83116538
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.81186100
40Increased IgE level (HP:0003212)2.80000905
41Petechiae (HP:0000967)2.74334310
42Increased serum ferritin (HP:0003281)2.72610963
43Urinary glycosaminoglycan excretion (HP:0003541)2.69604393
44Mucopolysacchariduria (HP:0008155)2.69604393
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.67786238
46Albinism (HP:0001022)2.66922258
47Polyneuropathy (HP:0001271)2.63718195
48Autoimmune hemolytic anemia (HP:0001890)2.63364879
49Neurofibrillary tangles (HP:0002185)2.61239185
50Joint swelling (HP:0001386)2.60872833
51Encephalitis (HP:0002383)2.60498062
52Arterial thrombosis (HP:0004420)2.60348171
53Axonal loss (HP:0003447)2.59224852
54Purpura (HP:0000979)2.57890364
55Hypergammaglobulinemia (HP:0010702)2.55734119
56Basal ganglia calcification (HP:0002135)2.53236500
57Progressive neurologic deterioration (HP:0002344)2.52914849
58Hemoptysis (HP:0002105)2.52826345
59Inappropriate behavior (HP:0000719)2.50558894
60Pigmentary retinal degeneration (HP:0001146)2.48894738
61Recurrent viral infections (HP:0004429)2.46599649
62Recurrent fungal infections (HP:0002841)2.42708874
63Amyloidosis (HP:0011034)2.39028749
64Apathy (HP:0000741)2.33828576
65Anorexia (HP:0002039)2.30884259
66Abnormality of iron homeostasis (HP:0011031)2.29542613
67Abnormality of B cell number (HP:0010975)2.29227372
68Keratitis (HP:0000491)2.28806868
69Episodic fever (HP:0001954)2.28005947
70Vertigo (HP:0002321)2.27130499
71Recurrent skin infections (HP:0001581)2.26724032
72Meningitis (HP:0001287)2.25726541
73Abnormality of the pleura (HP:0002103)2.24094294
74Obstructive lung disease (HP:0006536)2.21949002
75Chronic obstructive pulmonary disease (HP:0006510)2.21949002
76Nausea (HP:0002018)2.20516057
77Diminished motivation (HP:0000745)2.20466151
78Acne (HP:0001061)2.17300381
79Gingivitis (HP:0000230)2.16462225
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.15065498
81Leukocytosis (HP:0001974)2.13424168
82Complement deficiency (HP:0004431)2.09969347
83B lymphocytopenia (HP:0010976)2.08336082
84Abnormality of the pericardium (HP:0001697)2.07750994
85Malnutrition (HP:0004395)2.05707370
86Gastrointestinal infarctions (HP:0005244)2.05242434
87Memory impairment (HP:0002354)2.02255221
88Hepatosplenomegaly (HP:0001433)2.01849915
89T lymphocytopenia (HP:0005403)2.01643388
90Agnosia (HP:0010524)2.01544748
91Mesangial abnormality (HP:0001966)2.00862276
92Pulmonary embolism (HP:0002204)1.98639523
93Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98247233
94Abnormality of T cell number (HP:0011839)1.96690361
95Nephritis (HP:0000123)1.93583580
96IgA deficiency (HP:0002720)1.93504218
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93156951
98Prolonged neonatal jaundice (HP:0006579)1.93144917
99Zonular cataract (HP:0010920)1.91964934
100Abnormality of transition element cation homeostasis (HP:0011030)1.90241155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.33994968
2GRK73.55735823
3IKBKE3.24494658
4NME23.19215848
5TAOK23.08414402
6MAP3K143.02065113
7TBK12.95292005
8RIPK12.84636920
9IRAK42.69990483
10PIM22.56756216
11BLK2.50290775
12MAP3K112.40457940
13TYK22.37785962
14RIPK42.31920125
15IKBKB2.29638421
16MAP4K12.16234857
17PRKD32.04995203
18TAOK12.03352573
19MOS1.99521202
20MATK1.88402644
21DDR21.86284193
22TXK1.79935750
23ADRBK21.77309702
24MAP3K31.67286544
25BMPR21.55563038
26JAK31.52955353
27MAP2K61.52135889
28CSK1.52052094
29FGR1.48867113
30PRPF4B1.45142097
31TGFBR21.42713457
32ERN11.42081812
33IRAK11.41576043
34MAP2K31.37511426
35CHUK1.33032808
36CLK11.27318755
37PKN21.22904196
38STK101.22210763
39EPHA31.16825775
40ZAP701.15887442
41JAK11.15387618
42LYN1.12794346
43JAK21.11468150
44DYRK31.11362457
45MAP3K51.11082148
46SYK1.10187967
47HIPK21.05462283
48IRAK21.03834149
49CDC42BPA1.03775938
50MAP3K10.89222989
51LCK0.87771951
52MST40.86800426
53TESK20.84407783
54PIM10.83021875
55ABL20.80082794
56BTK0.74930180
57CSF1R0.74558717
58HCK0.69209990
59PKN10.67152051
60DAPK20.66853350
61ACVR1B0.66549723
62FLT30.62873537
63EPHB10.60239074
64BMX0.56173328
65MARK30.54640531
66FRK0.53757052
67LATS20.51425942
68MAP4K20.50480749
69TLK10.49289842
70CAMKK20.48727851
71MAPK40.47142266
72FES0.44722046
73KIT0.42674126
74MAP3K130.40234425
75DAPK30.38901481
76FGFR30.38407863
77TNK20.38335747
78SIK30.38045833
79EGFR0.37571878
80PDK10.34970507
81TESK10.31916664
82DYRK1B0.31896860
83GRK50.31499867
84ABL10.30616423
85RPS6KC10.29770186
86RPS6KL10.29770186
87MAPK70.28214851
88CDK60.28106377
89PAK10.28097946
90CCNB10.27689190
91STK160.26647139
92PRKCQ0.24422251
93RPS6KA60.24265806
94TYRO30.24099895
95GSK3A0.23232555
96INSR0.21993406
97MAPKAPK20.20526531
98SIK20.19940453
99PRKAA20.18458999
100ARAF0.18322990

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046203.24052345
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.99026328
3Asthma_Homo sapiens_hsa053102.93396241
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.89199599
5Allograft rejection_Homo sapiens_hsa053302.88688981
6Osteoclast differentiation_Homo sapiens_hsa043802.71731540
7Malaria_Homo sapiens_hsa051442.58075020
8Rheumatoid arthritis_Homo sapiens_hsa053232.55476864
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53014219
10Staphylococcus aureus infection_Homo sapiens_hsa051502.52076869
11Leishmaniasis_Homo sapiens_hsa051402.47297677
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.43336647
13TNF signaling pathway_Homo sapiens_hsa046682.37233184
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.31900731
15Pertussis_Homo sapiens_hsa051332.29875119
16Graft-versus-host disease_Homo sapiens_hsa053322.29539684
17African trypanosomiasis_Homo sapiens_hsa051432.23634097
18Autoimmune thyroid disease_Homo sapiens_hsa053202.20591706
19Other glycan degradation_Homo sapiens_hsa005112.20407002
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15621677
21Legionellosis_Homo sapiens_hsa051342.06769544
22Type I diabetes mellitus_Homo sapiens_hsa049402.04728646
23Tuberculosis_Homo sapiens_hsa051521.87920451
24Lysosome_Homo sapiens_hsa041421.82559379
25Influenza A_Homo sapiens_hsa051641.78745239
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75081202
27Salmonella infection_Homo sapiens_hsa051321.67434919
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61859197
29Measles_Homo sapiens_hsa051621.59353243
30Toxoplasmosis_Homo sapiens_hsa051451.57644590
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.55760666
32Hematopoietic cell lineage_Homo sapiens_hsa046401.49944269
33Herpes simplex infection_Homo sapiens_hsa051681.42543241
34Hepatitis C_Homo sapiens_hsa051601.36284340
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33456261
36Primary immunodeficiency_Homo sapiens_hsa053401.28181736
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.22415443
38Antigen processing and presentation_Homo sapiens_hsa046121.17743242
39Prion diseases_Homo sapiens_hsa050201.15100330
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10142479
41Viral myocarditis_Homo sapiens_hsa054161.09988852
42Chemokine signaling pathway_Homo sapiens_hsa040621.08475716
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.05698450
44B cell receptor signaling pathway_Homo sapiens_hsa046621.02896003
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01187808
46Hepatitis B_Homo sapiens_hsa051611.00101356
47Phagosome_Homo sapiens_hsa041450.96272700
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94593155
49Shigellosis_Homo sapiens_hsa051310.93779973
50T cell receptor signaling pathway_Homo sapiens_hsa046600.91210802
51Amoebiasis_Homo sapiens_hsa051460.83900969
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78429363
53Apoptosis_Homo sapiens_hsa042100.78415471
54Epstein-Barr virus infection_Homo sapiens_hsa051690.77958229
55Sulfur metabolism_Homo sapiens_hsa009200.76076996
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75369657
57Type II diabetes mellitus_Homo sapiens_hsa049300.74662985
58Prolactin signaling pathway_Homo sapiens_hsa049170.73077495
59Bladder cancer_Homo sapiens_hsa052190.69769583
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69615092
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69036997
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67996928
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66247501
64Complement and coagulation cascades_Homo sapiens_hsa046100.64531177
65Sphingolipid metabolism_Homo sapiens_hsa006000.64480660
66Acute myeloid leukemia_Homo sapiens_hsa052210.64431869
67Collecting duct acid secretion_Homo sapiens_hsa049660.59846786
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56244787
69VEGF signaling pathway_Homo sapiens_hsa043700.47206980
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42240967
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.41002645
72Galactose metabolism_Homo sapiens_hsa000520.39697880
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36939280
74Systemic lupus erythematosus_Homo sapiens_hsa053220.34814409
75HTLV-I infection_Homo sapiens_hsa051660.33971925
76Tryptophan metabolism_Homo sapiens_hsa003800.33752117
77Insulin resistance_Homo sapiens_hsa049310.33231089
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31657965
79Folate biosynthesis_Homo sapiens_hsa007900.28839953
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.28199810
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25976858
82Viral carcinogenesis_Homo sapiens_hsa052030.21853858
83Notch signaling pathway_Homo sapiens_hsa043300.20748975
84Endocytosis_Homo sapiens_hsa041440.20293394
85FoxO signaling pathway_Homo sapiens_hsa040680.19049941
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.18883418
87Fructose and mannose metabolism_Homo sapiens_hsa000510.18455702
88MAPK signaling pathway_Homo sapiens_hsa040100.18404495
89Dorso-ventral axis formation_Homo sapiens_hsa043200.18025372
90Platelet activation_Homo sapiens_hsa046110.17628061
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.16626676
92HIF-1 signaling pathway_Homo sapiens_hsa040660.15380182
93Mineral absorption_Homo sapiens_hsa049780.14321476
94Vibrio cholerae infection_Homo sapiens_hsa051100.12649268
95PPAR signaling pathway_Homo sapiens_hsa033200.09770456
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08270052
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07344134
98Arachidonic acid metabolism_Homo sapiens_hsa005900.03380837
99Chronic myeloid leukemia_Homo sapiens_hsa052200.03177856
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02945685

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