GPR50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1radial glial cell differentiation (GO:0060019)9.13375867
2lateral sprouting from an epithelium (GO:0060601)8.70024778
3otic vesicle formation (GO:0030916)7.91437984
4embryonic camera-type eye development (GO:0031076)7.00557101
5lung epithelium development (GO:0060428)6.74425906
6positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr6.53750769
7cilium movement (GO:0003341)6.17026243
8limb bud formation (GO:0060174)6.16211439
9forebrain neuron differentiation (GO:0021879)5.81112425
10regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 5.61306404
11mesenchymal-epithelial cell signaling (GO:0060638)5.42189915
12genitalia morphogenesis (GO:0035112)5.33685567
13regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.27592767
14histone H2B ubiquitination (GO:0033523)5.22217690
15fibroblast migration (GO:0010761)5.19087342
16muscle cell fate commitment (GO:0042693)5.04202463
17positive regulation of muscle cell apoptotic process (GO:0010661)4.93342286
18DNA replication-dependent nucleosome organization (GO:0034723)4.74480060
19DNA replication-dependent nucleosome assembly (GO:0006335)4.74480060
20cell fate commitment involved in formation of primary germ layer (GO:0060795)4.60906904
21mesonephros development (GO:0001823)4.58493028
22white fat cell differentiation (GO:0050872)4.37818288
23regulation of digestive system process (GO:0044058)4.36065241
24response to auditory stimulus (GO:0010996)4.35911984
25oxygen transport (GO:0015671)4.33346367
26presynaptic membrane assembly (GO:0097105)4.27334800
27axonemal dynein complex assembly (GO:0070286)4.21516823
28nonmotile primary cilium assembly (GO:0035058)4.15279168
29opioid receptor signaling pathway (GO:0038003)4.13303972
30positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.11095197
31microtubule depolymerization (GO:0007019)4.10982338
32cilium or flagellum-dependent cell motility (GO:0001539)4.09274113
33keratinocyte proliferation (GO:0043616)4.05435533
34kidney morphogenesis (GO:0060993)4.05143662
35establishment of nucleus localization (GO:0040023)4.04983824
36induction of positive chemotaxis (GO:0050930)3.97405762
37negative regulation of catenin import into nucleus (GO:0035414)3.94708749
38lung secretory cell differentiation (GO:0061140)3.90142419
39ventricular system development (GO:0021591)3.86751746
40axoneme assembly (GO:0035082)3.82383197
41positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.80741280
42positive regulation of mRNA 3-end processing (GO:0031442)3.80309136
43regulation of timing of cell differentiation (GO:0048505)3.74583693
44regulation of development, heterochronic (GO:0040034)3.72546121
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69392819
46base-excision repair, AP site formation (GO:0006285)3.67276415
47branch elongation of an epithelium (GO:0060602)3.66249271
48mitotic sister chromatid cohesion (GO:0007064)3.64275667
49organ growth (GO:0035265)3.61914415
50inner ear receptor stereocilium organization (GO:0060122)3.61504741
51neuron cell-cell adhesion (GO:0007158)3.60883962
52presynaptic membrane organization (GO:0097090)3.60636102
53DNA double-strand break processing (GO:0000729)3.52863501
54postreplication repair (GO:0006301)3.51788138
55regulation of keratinocyte proliferation (GO:0010837)3.50550357
56pituitary gland development (GO:0021983)3.50371366
57regulation of mRNA 3-end processing (GO:0031440)3.50259817
58regulation of smooth muscle cell apoptotic process (GO:0034391)3.49197009
59pyrimidine nucleobase catabolic process (GO:0006208)3.47604585
60protein localization to kinetochore (GO:0034501)3.45985192
61morphogenesis of an epithelial fold (GO:0060571)3.44944502
62cell wall macromolecule catabolic process (GO:0016998)3.44700117
63cell-cell signaling involved in cell fate commitment (GO:0045168)3.42634427
64protein localization to cell surface (GO:0034394)3.41723660
65positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)3.39216978
66determination of left/right symmetry (GO:0007368)3.35297969
67negative regulation of glial cell proliferation (GO:0060253)3.31278857
68regulation of RNA export from nucleus (GO:0046831)3.30472076
69left/right axis specification (GO:0070986)3.29198192
70ERK1 and ERK2 cascade (GO:0070371)3.26329606
71regulation of DNA endoreduplication (GO:0032875)3.24667885
72determination of bilateral symmetry (GO:0009855)3.23773049
73cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.23108667
74organ formation (GO:0048645)3.19679994
75cellular protein complex localization (GO:0034629)3.19149542
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17653633
77specification of symmetry (GO:0009799)3.13527982
78positive regulation of mRNA processing (GO:0050685)3.13238406
79mitotic spindle organization (GO:0007052)3.12234837
80regulation of sister chromatid cohesion (GO:0007063)3.11248440
81DNA strand renaturation (GO:0000733)3.09499544
82microtubule polymerization or depolymerization (GO:0031109)3.07587819
83labyrinthine layer blood vessel development (GO:0060716)3.07349704
84aggressive behavior (GO:0002118)3.04067129
85organ induction (GO:0001759)3.02645392
86neuroblast proliferation (GO:0007405)3.02510121
87regulation of tight junction assembly (GO:2000810)3.00790087
88acrosome assembly (GO:0001675)2.99699949
89response to dietary excess (GO:0002021)2.98398228
90negative regulation of cell cycle arrest (GO:0071157)2.97961551
91protein localization to chromosome, centromeric region (GO:0071459)2.97844898
92mesenchymal cell differentiation (GO:0048762)2.90669744
93nephron epithelium morphogenesis (GO:0072088)2.90265814
94nephron tubule morphogenesis (GO:0072078)2.90265814
95response to gravity (GO:0009629)2.89942757
96pyrimidine nucleotide catabolic process (GO:0006244)2.88131522
97regulation of synaptic vesicle exocytosis (GO:2000300)2.87835458
98axis elongation (GO:0003401)2.87570844
99gamma-aminobutyric acid transport (GO:0015812)2.86822655
100meiotic chromosome segregation (GO:0045132)2.83945428
101cell wall macromolecule metabolic process (GO:0044036)2.82332520
102regulation of nucleobase-containing compound transport (GO:0032239)2.82061800
103tissue regeneration (GO:0042246)2.81843649
104developmental induction (GO:0031128)2.81675902
105establishment of integrated proviral latency (GO:0075713)2.81226084
106embryonic digestive tract morphogenesis (GO:0048557)2.80394789
107SMAD protein signal transduction (GO:0060395)2.80267662
108regulation of transforming growth factor beta2 production (GO:0032909)2.79494633
109glial cell differentiation (GO:0010001)2.76888187
110establishment of viral latency (GO:0019043)2.75869637
111replication fork processing (GO:0031297)2.75687978
112neurotransmitter catabolic process (GO:0042135)2.75298514
113gastrulation with mouth forming second (GO:0001702)2.74129031
114nuclear envelope organization (GO:0006998)2.74020134
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.73944439
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73944439
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73944439
118histone H2A acetylation (GO:0043968)2.73694367
119nuclear envelope disassembly (GO:0051081)2.73359457
120membrane disassembly (GO:0030397)2.73359457
121peptidyl-histidine modification (GO:0018202)2.73190128
122branching involved in labyrinthine layer morphogenesis (GO:0060670)2.72942456
123cerebral cortex neuron differentiation (GO:0021895)2.72891966
124kinetochore organization (GO:0051383)2.72781362
125positive regulation of digestive system process (GO:0060456)2.72738325
126protein complex localization (GO:0031503)2.72677405
127mitotic nuclear envelope disassembly (GO:0007077)2.71274046
128DNA integration (GO:0015074)2.71257961
129DNA replication-independent nucleosome organization (GO:0034724)2.69493947
130DNA replication-independent nucleosome assembly (GO:0006336)2.69493947
131pancreas development (GO:0031016)2.68507519
132nucleus localization (GO:0051647)2.67286183
133synapsis (GO:0007129)2.65874710
134drinking behavior (GO:0042756)2.65633720
135negative regulation of gene silencing (GO:0060969)2.65530178
136DNA replication checkpoint (GO:0000076)2.65046784
137histone exchange (GO:0043486)2.64640320
138cholesterol biosynthetic process (GO:0006695)2.64553976
139G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64015439
140attachment of spindle microtubules to kinetochore (GO:0008608)2.63942007
141mitotic metaphase plate congression (GO:0007080)2.62762831
142motile cilium assembly (GO:0044458)2.61496568
143regulation of centriole replication (GO:0046599)2.61129670
144positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.60514915
145positive regulation of Notch signaling pathway (GO:0045747)2.59898445
146somite development (GO:0061053)2.59637702
147layer formation in cerebral cortex (GO:0021819)2.59264287
148mitotic sister chromatid segregation (GO:0000070)2.58313318
149olfactory bulb development (GO:0021772)2.58135915
150nucleobase catabolic process (GO:0046113)2.57938056
151chromatin remodeling at centromere (GO:0031055)2.57918274
152oligodendrocyte differentiation (GO:0048709)2.56991743
153mRNA splice site selection (GO:0006376)2.56811958
154oocyte development (GO:0048599)2.55925603
155spindle checkpoint (GO:0031577)2.54678962
156mitotic spindle checkpoint (GO:0071174)2.54584431
157sister chromatid segregation (GO:0000819)2.54560028
158neuronal stem cell maintenance (GO:0097150)2.54112371
159epithelial cilium movement (GO:0003351)2.53765401
160establishment of mitotic spindle orientation (GO:0000132)2.52939465
161peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.52503025
162parental behavior (GO:0060746)2.51861084
163DNA damage response, detection of DNA damage (GO:0042769)2.51387989
164centriole replication (GO:0007099)2.51178961
165positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50997865
166anterior/posterior axis specification, embryo (GO:0008595)2.50637016
167IMP biosynthetic process (GO:0006188)2.49302906
168L-serine metabolic process (GO:0006563)2.48033754
169maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47994973
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47828190
171nuclear pore complex assembly (GO:0051292)2.47418787
172long-term memory (GO:0007616)2.47052962
173apical protein localization (GO:0045176)2.46864537
174placenta blood vessel development (GO:0060674)2.46825078
175chondrocyte development (GO:0002063)2.46797302
176hair follicle morphogenesis (GO:0031069)2.46142996
177nuclear pore organization (GO:0006999)2.45732023
178regulation of nuclear cell cycle DNA replication (GO:0033262)2.44779369
179positive regulation of glomerulus development (GO:0090193)2.44679972
180prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.44420598
181positive regulation of dendritic spine morphogenesis (GO:0061003)2.44374520
182folic acid transport (GO:0015884)2.44255042
183glial cell migration (GO:0008347)2.43795502
184regulation of beta-amyloid formation (GO:1902003)2.43555999
185cell surface receptor signaling pathway involved in heart development (GO:0061311)2.43519718
186regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43009863
187purine nucleobase biosynthetic process (GO:0009113)2.42249491
188sister chromatid cohesion (GO:0007062)2.41842896
189double-strand break repair via nonhomologous end joining (GO:0006303)2.40661776
190non-recombinational repair (GO:0000726)2.40661776
191negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40094194
192nucleotide-excision repair, DNA gap filling (GO:0006297)2.40070541
193centrosome localization (GO:0051642)2.39261344
194negative regulation of DNA-dependent DNA replication (GO:2000104)2.38023178
195regulation of meiosis I (GO:0060631)2.37557162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.92981696
2E2F7_22180533_ChIP-Seq_HELA_Human4.56051762
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.92066112
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.52703688
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.48157330
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.27415111
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.17791093
8EZH2_22144423_ChIP-Seq_EOC_Human3.14116045
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99671800
10ZNF274_21170338_ChIP-Seq_K562_Hela2.80194041
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75509359
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75448660
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60274554
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49699169
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.49449938
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.43461779
17ELK1_19687146_ChIP-ChIP_HELA_Human2.36531850
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.34775253
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30900910
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.30618075
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29145685
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26348104
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.21207484
24TAF15_26573619_Chip-Seq_HEK293_Human2.19920126
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17090893
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16075633
27POU5F1_16153702_ChIP-ChIP_HESCs_Human2.15621378
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12849791
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08425727
30* EZH2_27304074_Chip-Seq_ESCs_Mouse2.02906834
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01312868
32* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01218186
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01133965
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99351956
35* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98851418
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97653367
37* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96608688
38* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96043033
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92457472
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.91128799
41* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89440850
42EWS_26573619_Chip-Seq_HEK293_Human1.88985261
43* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86565756
44* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86565756
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84804065
46* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84201706
47* EED_16625203_ChIP-ChIP_MESCs_Mouse1.81486516
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.80433396
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78956980
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73166857
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73065461
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71376707
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70835213
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69715093
55SMAD4_21799915_ChIP-Seq_A2780_Human1.68132245
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68013449
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.65891658
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63648311
59VDR_22108803_ChIP-Seq_LS180_Human1.63428392
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62955812
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.61317422
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60633720
63FUS_26573619_Chip-Seq_HEK293_Human1.58383196
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56984616
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.56197644
66* RNF2_27304074_Chip-Seq_NSC_Mouse1.55867171
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53848457
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53626391
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52808018
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.51874203
71MYC_18940864_ChIP-ChIP_HL60_Human1.50106457
72ZNF263_19887448_ChIP-Seq_K562_Human1.48276932
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48215013
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48215013
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48215013
76VDR_23849224_ChIP-Seq_CD4+_Human1.47659254
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.46986559
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.46848566
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46494530
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.45594425
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.44511147
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.44048355
83* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43311080
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.41929462
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41917658
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41917658
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40473811
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.40092220
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.39213730
90AR_21909140_ChIP-Seq_LNCAP_Human1.38325942
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37109360
92FOXP3_21729870_ChIP-Seq_TREG_Human1.36157889
93TTF2_22483619_ChIP-Seq_HELA_Human1.35419204
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34444747
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32566306
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32236857
97GABP_19822575_ChIP-Seq_HepG2_Human1.31047501
98DROSHA_22980978_ChIP-Seq_HELA_Human1.29440914
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28658574
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28312347
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28061573
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27863509
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27455761
104DCP1A_22483619_ChIP-Seq_HELA_Human1.26298074
105P300_19829295_ChIP-Seq_ESCs_Human1.25600789
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25445018
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25237967
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24149892
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23921849
110XRN2_22483619_ChIP-Seq_HELA_Human1.23594324
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.23539369
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21493002
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.18596301
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.18529004
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15804556
116REST_21632747_ChIP-Seq_MESCs_Mouse1.15115533
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14101358
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11481935
119* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09845088
120AR_25329375_ChIP-Seq_VCAP_Human1.09443143
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08344940
122MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08114944
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.08014001
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07810833
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07735412
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06980654
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.06803822
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.06725330
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06160185
130BCAT_22108803_ChIP-Seq_LS180_Human1.05857923
131AR_21572438_ChIP-Seq_LNCaP_Human1.05676905
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05069598
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04623039
134CIITA_25753668_ChIP-Seq_RAJI_Human1.03631872
135KDM5A_27292631_Chip-Seq_BREAST_Human1.03383319
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03128490
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01635043
138DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01246078
139SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00766049
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00413565
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.98609561
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97947697
143CLOCK_20551151_ChIP-Seq_293T_Human0.96799860
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96662525
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96406321
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96375020
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94815888
148RARB_27405468_Chip-Seq_BRAIN_Mouse0.94788374
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94670216
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.94598039
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94591661
152CBP_20019798_ChIP-Seq_JUKART_Human0.94591661
153RUNX2_22187159_ChIP-Seq_PCA_Human0.94346684
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94225487
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94039701
156THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94022042
157E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93937465
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93855441
159TP53_22573176_ChIP-Seq_HFKS_Human0.93621342
160STAT3_23295773_ChIP-Seq_U87_Human0.93203833
161TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91868310
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91441532
163GBX2_23144817_ChIP-Seq_PC3_Human0.91225075
164KDM2B_26808549_Chip-Seq_K562_Human0.90115887
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90060347
166CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89956230
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89627080
168POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.89554747
169FLI1_27457419_Chip-Seq_LIVER_Mouse0.88520874
170GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88400307
171* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88292267
172GATA1_26923725_Chip-Seq_HPCs_Mouse0.88074824
173ARNT_22903824_ChIP-Seq_MCF-7_Human0.87455251
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87443304
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.85338916
176ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84846559
177YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84085578
178KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83579535
179PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82785945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology5.79981086
2MP0002132_abnormal_respiratory_system5.06328081
3MP0003122_maternal_imprinting4.23387562
4MP0005248_abnormal_Harderian_gland4.04517850
5MP0002277_abnormal_respiratory_mucosa3.92099185
6MP0010368_abnormal_lymphatic_system3.36453240
7MP0006292_abnormal_olfactory_placode3.30843754
8MP0008057_abnormal_DNA_replication3.18692789
9MP0008789_abnormal_olfactory_epithelium3.14741571
10MP0006072_abnormal_retinal_apoptosis2.94977449
11MP0002163_abnormal_gland_morphology2.93103091
12MP0005394_taste/olfaction_phenotype2.74233301
13MP0005499_abnormal_olfactory_system2.74233301
14MP0001293_anophthalmia2.71118185
15MP0003690_abnormal_glial_cell2.70409347
16MP0002295_abnormal_pulmonary_circulatio2.67335503
17MP0003121_genomic_imprinting2.54445245
18MP0005379_endocrine/exocrine_gland_phen2.54079948
19MP0003693_abnormal_embryo_hatching2.45291079
20MP0001529_abnormal_vocalization2.42131792
21MP0003123_paternal_imprinting2.39876139
22MP0004858_abnormal_nervous_system2.34887678
23MP0004859_abnormal_synaptic_plasticity2.33353627
24MP0008058_abnormal_DNA_repair2.24905562
25MP0010094_abnormal_chromosome_stability2.23211992
26MP0001879_abnormal_lymphatic_vessel2.16355336
27MP0009250_abnormal_appendicular_skeleto2.13631741
28MP0003111_abnormal_nucleus_morphology2.13251044
29MP0001984_abnormal_olfaction2.00052525
30MP0005645_abnormal_hypothalamus_physiol1.96733875
31MP0005623_abnormal_meninges_morphology1.95328457
32MP0003938_abnormal_ear_development1.93266719
33MP0000537_abnormal_urethra_morphology1.89460549
34MP0008872_abnormal_physiological_respon1.85126291
35MP0003077_abnormal_cell_cycle1.84693698
36MP0009384_cardiac_valve_regurgitation1.77860657
37MP0002638_abnormal_pupillary_reflex1.72883388
38MP0005670_abnormal_white_adipose1.70592727
39MP0009053_abnormal_anal_canal1.70200709
40MP0002234_abnormal_pharynx_morphology1.67639690
41MP0003890_abnormal_embryonic-extraembry1.65743710
42MP0004270_analgesia1.61909279
43MP0000613_abnormal_salivary_gland1.57532701
44MP0003718_maternal_effect1.55832015
45MP0001348_abnormal_lacrimal_gland1.55818962
46MP0000566_synostosis1.54706449
47MP0003635_abnormal_synaptic_transmissio1.49980411
48MP0002735_abnormal_chemical_nociception1.48545004
49MP0005646_abnormal_pituitary_gland1.46033281
50MP0004272_abnormal_basement_membrane1.45052821
51MP0003880_abnormal_central_pattern1.44954425
52MP0001440_abnormal_grooming_behavior1.40325997
53MP0008932_abnormal_embryonic_tissue1.39131187
54MP0000762_abnormal_tongue_morphology1.37079932
55MP0002751_abnormal_autonomic_nervous1.36628606
56MP0004957_abnormal_blastocyst_morpholog1.36360802
57MP0001501_abnormal_sleep_pattern1.35764602
58MP0005391_vision/eye_phenotype1.33609399
59MP0002092_abnormal_eye_morphology1.33569596
60MP0001919_abnormal_reproductive_system1.30192515
61MP0002733_abnormal_thermal_nociception1.30136249
62MP0001968_abnormal_touch/_nociception1.29237040
63MP0001286_abnormal_eye_development1.28814252
64MP0003937_abnormal_limbs/digits/tail_de1.28491516
65MP0004134_abnormal_chest_morphology1.28041821
66MP0003755_abnormal_palate_morphology1.27894819
67MP0002233_abnormal_nose_morphology1.27669364
68MP0002063_abnormal_learning/memory/cond1.25934880
69MP0002734_abnormal_mechanical_nocicepti1.24813531
70MP0002084_abnormal_developmental_patter1.24549420
71MP0010030_abnormal_orbit_morphology1.23583308
72MP0006276_abnormal_autonomic_nervous1.23557560
73MP0000383_abnormal_hair_follicle1.23409660
74MP0009046_muscle_twitch1.23384134
75MP0008877_abnormal_DNA_methylation1.22373609
76MP0001970_abnormal_pain_threshold1.22037948
77MP0002876_abnormal_thyroid_physiology1.21530134
78MP0005367_renal/urinary_system_phenotyp1.20593651
79MP0000516_abnormal_urinary_system1.20593651
80MP0002085_abnormal_embryonic_tissue1.16839048
81MP0001697_abnormal_embryo_size1.16548542
82MP0004133_heterotaxia1.13485380
83MP0009703_decreased_birth_body1.13294773
84MP0002064_seizures1.12168644
85MP0008961_abnormal_basal_metabolism1.11800445
86MP0002697_abnormal_eye_size1.11104990
87MP0008995_early_reproductive_senescence1.10914513
88MP0003119_abnormal_digestive_system1.10197285
89MP0000631_abnormal_neuroendocrine_gland1.08595802
90MP0001730_embryonic_growth_arrest1.07176340
91MP0009745_abnormal_behavioral_response1.06442590
92MP0003385_abnormal_body_wall1.05970105
93MP0003787_abnormal_imprinting1.05686655
94MP0003303_peritoneal_inflammation1.03708759
95MP0002653_abnormal_ependyma_morphology1.03567054
96MP0002557_abnormal_social/conspecific_i1.00490849
97MP0002736_abnormal_nociception_after0.98585176
98MP0002752_abnormal_somatic_nervous0.98005914
99MP0003329_amyloid_beta_deposits0.96689177
100MP0003567_abnormal_fetal_cardiomyocyte0.96457959
101MP0001929_abnormal_gametogenesis0.96387893
102MP0003698_abnormal_male_reproductive0.95216536
103MP0002184_abnormal_innervation0.94618995
104MP0009672_abnormal_birth_weight0.94496302
105MP0002090_abnormal_vision0.94440482
106MP0002152_abnormal_brain_morphology0.93621318
107MP0005380_embryogenesis_phenotype0.93404236
108MP0001672_abnormal_embryogenesis/_devel0.93404236
109MP0008875_abnormal_xenobiotic_pharmacok0.93344778
110MP0002177_abnormal_outer_ear0.90607147
111MP0002572_abnormal_emotion/affect_behav0.87437616
112MP0005187_abnormal_penis_morphology0.86421577
113MP0003638_abnormal_response/metabolism_0.86331345
114MP0000428_abnormal_craniofacial_morphol0.86155155
115MP0000778_abnormal_nervous_system0.85845310
116MP0005165_increased_susceptibility_to0.84541680
117MP0000749_muscle_degeneration0.84378158
118MP0003786_premature_aging0.84162967
119MP0002088_abnormal_embryonic_growth/wei0.82732280
120MP0003935_abnormal_craniofacial_develop0.82436040
121MP0000026_abnormal_inner_ear0.82198607
122MP0005253_abnormal_eye_physiology0.81552452
123MP0000427_abnormal_hair_cycle0.81114011
124MP0002249_abnormal_larynx_morphology0.79906753
125MP0004811_abnormal_neuron_physiology0.79839488
126MP0001177_atelectasis0.79577368
127MP0003136_yellow_coat_color0.79051087
128MP0003634_abnormal_glial_cell0.78971136
129MP0003115_abnormal_respiratory_system0.78190606
130MP0005195_abnormal_posterior_eye0.78024018
131MP0002210_abnormal_sex_determination0.77735885
132MP0010678_abnormal_skin_adnexa0.77609416
133MP0000647_abnormal_sebaceous_gland0.77185418
134MP0002882_abnormal_neuron_morphology0.77161029
135MP0000750_abnormal_muscle_regeneration0.75752329
136MP0001145_abnormal_male_reproductive0.75599271
137MP0001661_extended_life_span0.75545613
138MP0000653_abnormal_sex_gland0.75450985
139MP0001346_abnormal_lacrimal_gland0.75366825
140MP0005023_abnormal_wound_healing0.72045512
141MP0002111_abnormal_tail_morphology0.71456452
142MP0001486_abnormal_startle_reflex0.71397262
143MP0002115_abnormal_skeleton_extremities0.71376767
144MP0004145_abnormal_muscle_electrophysio0.70895545
145MP0002116_abnormal_craniofacial_bone0.69341772
146MP0002272_abnormal_nervous_system0.68963723
147MP0005310_abnormal_salivary_gland0.68875582
148MP0000163_abnormal_cartilage_morphology0.65812502
149MP0004924_abnormal_behavior0.65804899
150MP0005386_behavior/neurological_phenoty0.65804899
151MP0002282_abnormal_trachea_morphology0.62816748
152MP0000639_abnormal_adrenal_gland0.62489418
153MP0005193_abnormal_anterior_eye0.61942425
154MP0004142_abnormal_muscle_tone0.59686476
155MP0004197_abnormal_fetal_growth/weight/0.59391998
156MP0000955_abnormal_spinal_cord0.59342943
157MP0001943_abnormal_respiration0.58993500
158MP0001340_abnormal_eyelid_morphology0.58736939
159MP0000049_abnormal_middle_ear0.57692479
160MP0002128_abnormal_blood_circulation0.57079482
161MP0002909_abnormal_adrenal_gland0.56687877
162MP0003861_abnormal_nervous_system0.55442094

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)7.70936446
2Aplasia of the phalanges of the hand (HP:0009802)7.70936446
3Aplasia involving bones of the extremities (HP:0009825)7.70936446
4Abnormal ciliary motility (HP:0012262)7.56654558
5Abnormal respiratory motile cilium physiology (HP:0012261)6.55364154
6Partial duplication of thumb phalanx (HP:0009944)5.77672808
7Partial duplication of the phalanx of hand (HP:0009999)5.30786788
8Alacrima (HP:0000522)4.60503224
9Volvulus (HP:0002580)4.29282342
10Hyperglycinemia (HP:0002154)4.18972731
11Recurrent corneal erosions (HP:0000495)4.18029267
12Conical tooth (HP:0000698)3.97750541
13Mixed hearing impairment (HP:0000410)3.96805463
14Abnormality of incisor morphology (HP:0011063)3.94992221
15Nasolacrimal duct obstruction (HP:0000579)3.86625532
16Xerostomia (HP:0000217)3.65536857
17Abnormality of permanent molar morphology (HP:0011071)3.62368361
18Abnormality of the dental root (HP:0006486)3.62368361
19Taurodontia (HP:0000679)3.62368361
20Abnormality of the salivary glands (HP:0010286)3.56920514
21Rhinitis (HP:0012384)3.47841019
22Decreased lacrimation (HP:0000633)3.44208833
23Abnormality of molar morphology (HP:0011070)3.42172577
24Abnormality of molar (HP:0011077)3.42172577
25Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.42077931
26Abnormal respiratory epithelium morphology (HP:0012253)3.38241679
27Abnormal respiratory motile cilium morphology (HP:0005938)3.38241679
28Abnormality of the lower motor neuron (HP:0002366)3.37082938
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.35167530
30Polyphagia (HP:0002591)3.33037852
31Asymmetry of the thorax (HP:0001555)3.28698737
32Hypoplasia of the ulna (HP:0003022)3.25384474
33Abnormal pupillary function (HP:0007686)3.21839849
34Gait imbalance (HP:0002141)3.16106522
35Broad hallux (HP:0010055)3.15926768
36Abnormality of the dental pulp (HP:0006479)3.15790601
37Abnormality of the lacrimal duct (HP:0011481)3.14844719
38Congenital primary aphakia (HP:0007707)3.12402819
39Medial flaring of the eyebrow (HP:0010747)3.08856631
40Shoulder girdle muscle weakness (HP:0003547)3.08480578
41High anterior hairline (HP:0009890)3.06015670
42Dyskinesia (HP:0100660)3.05541431
43Abnormality of glycine metabolism (HP:0010895)2.91953072
44Abnormality of serine family amino acid metabolism (HP:0010894)2.91953072
45Amyotrophic lateral sclerosis (HP:0007354)2.90937887
46Broad toe (HP:0001837)2.84721983
47Aplasia/Hypoplasia of the ulna (HP:0006495)2.82851331
48Abnormality of the nasolacrimal system (HP:0000614)2.78699491
49Hyperglycinuria (HP:0003108)2.77940409
50Lissencephaly (HP:0001339)2.77367377
51Bronchiectasis (HP:0002110)2.75520815
52Preaxial foot polydactyly (HP:0001841)2.72507218
53Vitreoretinal degeneration (HP:0000655)2.69393704
54Broad foot (HP:0001769)2.68543696
55Nephrogenic diabetes insipidus (HP:0009806)2.66291495
56Abnormality of the musculature of the hand (HP:0001421)2.63571987
57Vaginal atresia (HP:0000148)2.61753302
58Specific learning disability (HP:0001328)2.60083014
59Supernumerary spleens (HP:0009799)2.58897290
60Genital tract atresia (HP:0001827)2.51693465
61Rimmed vacuoles (HP:0003805)2.48196949
62Abnormality of salivation (HP:0100755)2.47189243
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.46545516
64Abnormal eating behavior (HP:0100738)2.43229309
65Renal hypoplasia (HP:0000089)2.42592899
66Pelvic girdle muscle weakness (HP:0003749)2.40515647
67Ependymoma (HP:0002888)2.40411021
68Abnormality of the labia minora (HP:0012880)2.40140562
69Abnormality of the hip-girdle musculature (HP:0001445)2.37641084
70Abnormality of the musculature of the pelvis (HP:0001469)2.37641084
71Retinal dysplasia (HP:0007973)2.34354938
72Muscular dystrophy (HP:0003560)2.34346681
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.34338348
74Abnormality of the antihelix (HP:0009738)2.31851707
75Arterial tortuosity (HP:0005116)2.28299626
76Hyperextensible skin (HP:0000974)2.28035324
77Narrow nasal bridge (HP:0000446)2.27590167
78Abnormality of binocular vision (HP:0011514)2.24000052
79Diplopia (HP:0000651)2.24000052
80Visual hallucinations (HP:0002367)2.22226959
81Tented upper lip vermilion (HP:0010804)2.21174999
82Poor coordination (HP:0002370)2.20624048
83Increased variability in muscle fiber diameter (HP:0003557)2.19595028
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17950915
85Duplication of thumb phalanx (HP:0009942)2.17930828
86Shawl scrotum (HP:0000049)2.14749958
87Focal seizures (HP:0007359)2.13947460
88Failure to thrive in infancy (HP:0001531)2.13747731
89Dental crowding (HP:0000678)2.12066914
90Cortical dysplasia (HP:0002539)2.10700718
91Spondylolisthesis (HP:0003302)2.10315485
92Coronal craniosynostosis (HP:0004440)2.09492199
93Flat capital femoral epiphysis (HP:0003370)2.08200492
94Facial hemangioma (HP:0000329)2.07704336
95Anencephaly (HP:0002323)2.07239611
96Tubulointerstitial fibrosis (HP:0005576)2.05920268
97Impulsivity (HP:0100710)2.05489916
98Decreased testicular size (HP:0008734)2.05452072
99Abnormal lung lobation (HP:0002101)2.03915585
100Increased nuchal translucency (HP:0010880)2.03904656
101Abdominal situs inversus (HP:0003363)2.03861624
102Abnormality of abdominal situs (HP:0011620)2.03861624
103Postaxial hand polydactyly (HP:0001162)2.03211593
104Cupped ear (HP:0000378)2.03195960
105Abnormality of the incisor (HP:0000676)2.02445934
106Abnormality of serum amino acid levels (HP:0003112)2.02208300
107Myelomeningocele (HP:0002475)2.02103029
108Methylmalonic acidemia (HP:0002912)2.01593494
109Optic nerve hypoplasia (HP:0000609)2.01430067
110Absent radius (HP:0003974)2.01095082
111Vascular tortuosity (HP:0004948)2.00954736
112Focal motor seizures (HP:0011153)2.00674105
113Atrioventricular block (HP:0001678)2.00517426
114Bilateral microphthalmos (HP:0007633)1.99719708
115Type II lissencephaly (HP:0007260)1.99019090
116Concave nail (HP:0001598)1.98861399
117Clumsiness (HP:0002312)1.98714023
118Gastroesophageal reflux (HP:0002020)1.98324924
119Abnormality of glycolysis (HP:0004366)1.95861834
120Proximal amyotrophy (HP:0007126)1.95267492
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94669595
122Confusion (HP:0001289)1.94568047
123Short nail (HP:0001799)1.93143492
124Multicystic kidney dysplasia (HP:0000003)1.91461702
125Aplasia involving forearm bones (HP:0009822)1.89446024
126Absent forearm bone (HP:0003953)1.89446024
127Breast hypoplasia (HP:0003187)1.88667589
128Infertility (HP:0000789)1.88502685
129Abnormality of midbrain morphology (HP:0002418)1.88305885
130Molar tooth sign on MRI (HP:0002419)1.88305885
131Drooling (HP:0002307)1.88015436
132Excessive salivation (HP:0003781)1.88015436
133Stenosis of the external auditory canal (HP:0000402)1.87955891
134Septo-optic dysplasia (HP:0100842)1.87490241
135Esotropia (HP:0000565)1.86138620
136Abnormality of the middle phalanges of the toes (HP:0010183)1.85735299
137Overfolded helix (HP:0000396)1.84274797
138Abnormality of dentin (HP:0010299)1.83812531
139Thin upper lip vermilion (HP:0000219)1.83646733
140Hypoplasia of the radius (HP:0002984)1.82501916
141Achilles tendon contracture (HP:0001771)1.81338182
142Megalencephaly (HP:0001355)1.80784233
143Intestinal atresia (HP:0011100)1.80760630
144Micropenis (HP:0000054)1.79865022
145Hemivertebrae (HP:0002937)1.79745475
146Astigmatism (HP:0000483)1.79465933
147Preaxial hand polydactyly (HP:0001177)1.79419897
148Nephronophthisis (HP:0000090)1.79174071
149Limb hypertonia (HP:0002509)1.78824108
150Progressive cerebellar ataxia (HP:0002073)1.78699145
151Spastic tetraplegia (HP:0002510)1.77947272
152Myokymia (HP:0002411)1.77895595
153Spastic diplegia (HP:0001264)1.77464771
154Hemiparesis (HP:0001269)1.76595773
155Abnormality of the proximal phalanges of the hand (HP:0009834)1.76440276
156Anophthalmia (HP:0000528)1.76235705
157Pachygyria (HP:0001302)1.75546943
158Atelectasis (HP:0100750)1.75057420
159Pendular nystagmus (HP:0012043)1.74210418
160Autoimmune thrombocytopenia (HP:0001973)1.73314576
161Oligodactyly (hands) (HP:0001180)1.73056021
162Astrocytoma (HP:0009592)1.72999255
163Abnormality of the astrocytes (HP:0100707)1.72999255
164Split foot (HP:0001839)1.72733237
165Renal dysplasia (HP:0000110)1.72058663
166Abnormally folded helix (HP:0008544)1.71387585
167Abnormality of the Achilles tendon (HP:0005109)1.71206016
168True hermaphroditism (HP:0010459)1.70603550
169Pancreatic cysts (HP:0001737)1.69906723
170Postnatal microcephaly (HP:0005484)1.69552369
171Anal atresia (HP:0002023)1.68054273
172Bifid tongue (HP:0010297)1.67431679
173Abnormality of skeletal muscle fiber size (HP:0012084)1.66772174
174Mesangial abnormality (HP:0001966)1.66564747
175Oligodactyly (HP:0012165)1.66119270
176Ectopic kidney (HP:0000086)1.66025350
177Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.65821473
178Spinal rigidity (HP:0003306)1.63933188
179Scrotal hypoplasia (HP:0000046)1.63401404
180Abnormality of the renal medulla (HP:0100957)1.63285741
181Abnormality of macular pigmentation (HP:0008002)1.62884348
182Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62561744
183Aplasia/Hypoplasia of the lens (HP:0008063)1.61692373
184Lymphangioma (HP:0100764)1.60689376
185Vertebral hypoplasia (HP:0008417)1.60550012
186Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60550012
187Forearm undergrowth (HP:0009821)1.60531271
188Meningocele (HP:0002435)1.59863375
189Muscle fiber atrophy (HP:0100295)1.58270934
190Rapidly progressive (HP:0003678)1.56517305
191Neonatal short-limb short stature (HP:0008921)1.55489389
192Oligomenorrhea (HP:0000876)1.53763098
193Epileptic encephalopathy (HP:0200134)1.51978178
194Epiphyseal dysplasia (HP:0002656)1.51889652
195Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.51504807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.44013817
2NTRK23.54578570
3BCR3.51434551
4MAPK153.50204637
5PIK3CG3.38012054
6LATS23.09620950
7MAP4K23.01718107
8CASK2.97787985
9GRK72.88317165
10IRAK22.66286476
11MARK12.56117733
12MAP3K102.48348498
13PLK42.41492707
14VRK22.36712865
15ERBB42.27917409
16CDC72.26165316
17WEE12.20328894
18IRAK12.16025040
19NEK12.09305793
20ADRBK22.02889977
21DYRK1B1.99005599
22TRIM281.94156664
23TNIK1.91165630
24MKNK11.83005707
25NTRK31.79313553
26SCYL21.74698212
27PNCK1.67149650
28BRD41.59980238
29MKNK21.59973640
30MAP2K21.53989103
31WNK31.49815848
32CDK31.47180026
33PAK31.45276565
34AURKA1.43237408
35ATR1.31752985
36FER1.31698804
37VRK11.31191554
38NUAK11.30610398
39TTK1.30086243
40MAPKAPK51.26249872
41DDR21.25937752
42ERBB31.25359672
43PAK21.21752775
44TSSK61.20432071
45CSNK1G31.20308925
46MAPK101.17528594
47TYRO31.16105753
48MAP3K121.11602710
49CHEK21.11495293
50BCKDK1.10385509
51GSK3A1.06697173
52MAPK41.06379835
53FRK1.05052738
54CSNK1G21.04374650
55CAMKK11.03446722
56CSNK1A1L1.03046607
57KSR21.00524953
58LIMK11.00468917
59EIF2AK10.98567778
60BUB10.96395832
61EIF2AK30.96138245
62HIPK20.95045700
63PDK20.93577292
64PHKG10.92875270
65PHKG20.92875270
66PAK60.91744746
67PLK10.89946823
68STK390.89305224
69RPS6KA20.84788343
70MAPK120.83390557
71GRK10.83200064
72DYRK30.82263939
73MAPK70.80729349
74UHMK10.80309029
75EPHA40.79884434
76MAP3K50.78882978
77AURKB0.76601094
78BRSK10.75258986
79FGFR20.74294278
80CSNK1G10.73138434
81ATM0.72086421
82PRKCG0.71534990
83LATS10.70268962
84NME10.70264039
85MINK10.69712357
86ADRBK10.68905662
87LMTK20.68904279
88PTK20.68211627
89FES0.67457842
90MAP3K40.67418701
91CSNK1E0.67008786
92CHEK10.66953386
93MAP2K10.65877615
94PINK10.64156413
95CDK50.63627723
96MET0.62651964
97FGR0.62231546
98ROCK20.60525055
99CAMK2B0.60388319
100ROCK10.60228366
101MAP2K40.59370957
102PLK30.59270319
103MAP3K110.58680586
104STK38L0.57757167
105CAMK2A0.57474486
106RPS6KB20.55879965
107TAOK10.55243299
108MAP2K70.55099958
109NTRK10.54325901
110EPHB20.54153791
111FGFR10.53565835
112CDK70.52968965
113ABL20.52819991
114MAPK130.52362059
115ALK0.51898599
116AKT20.51567049
117MOS0.51249207
118CAMK2G0.50922069
119CAMK10.50316618
120CDK20.50191992
121SRPK10.50075929
122CDK10.49855509
123MAPK90.49821685
124NLK0.49799904
125EPHB10.49166618
126WNK40.48445318
127STK30.48276076
128SIK20.46854711
129RPS6KA40.46590237
130CDK60.46509116
131CDK120.46157268
132PDGFRA0.46101663
133CDK190.45874142
134PRKCE0.44667768
135TESK20.44507039
136OXSR10.44422267
137PRKDC0.43847512
138PLK20.43766150
139INSRR0.43684618
140DYRK1A0.43650432
141EIF2AK20.42647840
142BRSK20.42603866
143YES10.42259599
144NEK20.42047135
145PRKACB0.41774981
146CAMK2D0.41022411
147LRRK20.40771204
148PASK0.39988786
149TRIB30.39383944
150RAF10.39268196
151EPHA30.38800318
152PRKAA20.38494676
153RPS6KA30.37892646
154CDK140.37079642
155CDK180.36226850
156GSK3B0.35447948
157CDK11A0.35379049
158MAPK80.35097271
159SGK10.34563792
160SGK2230.33349647
161SGK4940.33349647
162DYRK20.33236919
163CDK150.32128712
164MUSK0.31691088
165CSNK2A10.30947108
166SRC0.30857965
167PTK2B0.30752282

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.26308405
2Nicotine addiction_Homo sapiens_hsa050333.39724998
3Non-homologous end-joining_Homo sapiens_hsa034503.37101334
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.17535619
5Spliceosome_Homo sapiens_hsa030403.10117461
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.99318587
7Steroid biosynthesis_Homo sapiens_hsa001002.93870902
8Nitrogen metabolism_Homo sapiens_hsa009102.75804815
9Base excision repair_Homo sapiens_hsa034102.62737943
10DNA replication_Homo sapiens_hsa030302.62199638
11GABAergic synapse_Homo sapiens_hsa047272.42000918
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25368586
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22984716
14Cocaine addiction_Homo sapiens_hsa050302.14781994
15RNA transport_Homo sapiens_hsa030132.10946834
16Propanoate metabolism_Homo sapiens_hsa006402.08726261
17RNA polymerase_Homo sapiens_hsa030202.02112257
18Amphetamine addiction_Homo sapiens_hsa050312.00109604
19Cell cycle_Homo sapiens_hsa041101.93995687
20Protein export_Homo sapiens_hsa030601.93629798
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91966662
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81269105
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80929104
24Circadian entrainment_Homo sapiens_hsa047131.74722111
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73566273
26Mismatch repair_Homo sapiens_hsa034301.72646843
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70551988
28Estrogen signaling pathway_Homo sapiens_hsa049151.69639139
29Long-term depression_Homo sapiens_hsa047301.69237183
30Fanconi anemia pathway_Homo sapiens_hsa034601.68028812
31Proteasome_Homo sapiens_hsa030501.66902009
32Basal transcription factors_Homo sapiens_hsa030221.66625601
33Nucleotide excision repair_Homo sapiens_hsa034201.65815530
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64688314
35mRNA surveillance pathway_Homo sapiens_hsa030151.64504761
36Renal cell carcinoma_Homo sapiens_hsa052111.62885142
37Salivary secretion_Homo sapiens_hsa049701.61714998
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60934714
39Biosynthesis of amino acids_Homo sapiens_hsa012301.60631150
40Renin secretion_Homo sapiens_hsa049241.59960143
41Pentose phosphate pathway_Homo sapiens_hsa000301.57328034
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56872678
43Morphine addiction_Homo sapiens_hsa050321.48855088
44Glutamatergic synapse_Homo sapiens_hsa047241.44671460
45Cholinergic synapse_Homo sapiens_hsa047251.43796080
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42791165
47Choline metabolism in cancer_Homo sapiens_hsa052311.41156455
48Thyroid hormone synthesis_Homo sapiens_hsa049181.38582023
49Carbon metabolism_Homo sapiens_hsa012001.37552737
50Selenocompound metabolism_Homo sapiens_hsa004501.36594575
51RNA degradation_Homo sapiens_hsa030181.32694602
52Insulin secretion_Homo sapiens_hsa049111.30525747
53Gap junction_Homo sapiens_hsa045401.28666429
54Homologous recombination_Homo sapiens_hsa034401.28045246
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24108777
56Hedgehog signaling pathway_Homo sapiens_hsa043401.23946927
57p53 signaling pathway_Homo sapiens_hsa041151.17392769
58* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16972281
59PPAR signaling pathway_Homo sapiens_hsa033201.15906237
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14646903
61Dopaminergic synapse_Homo sapiens_hsa047281.12209758
62Melanogenesis_Homo sapiens_hsa049161.10590300
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10573843
64Melanoma_Homo sapiens_hsa052181.09264653
65Pyruvate metabolism_Homo sapiens_hsa006201.07875269
66Basal cell carcinoma_Homo sapiens_hsa052171.06908214
67MAPK signaling pathway_Homo sapiens_hsa040101.03068605
68Dilated cardiomyopathy_Homo sapiens_hsa054141.02536846
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.00681902
70Phototransduction_Homo sapiens_hsa047441.00458304
71Butanoate metabolism_Homo sapiens_hsa006500.99278208
72Prion diseases_Homo sapiens_hsa050200.99009270
73Pyrimidine metabolism_Homo sapiens_hsa002400.97884707
74Peroxisome_Homo sapiens_hsa041460.97188518
75cAMP signaling pathway_Homo sapiens_hsa040240.96571520
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96308443
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95051226
78Oocyte meiosis_Homo sapiens_hsa041140.94452221
79Long-term potentiation_Homo sapiens_hsa047200.94415870
80Oxytocin signaling pathway_Homo sapiens_hsa049210.93838146
81Purine metabolism_Homo sapiens_hsa002300.93577048
82GnRH signaling pathway_Homo sapiens_hsa049120.93493816
83Axon guidance_Homo sapiens_hsa043600.92716706
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.92145447
85Ether lipid metabolism_Homo sapiens_hsa005650.91195967
86Serotonergic synapse_Homo sapiens_hsa047260.89482416
87Bile secretion_Homo sapiens_hsa049760.88027987
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87919175
89Fatty acid elongation_Homo sapiens_hsa000620.87853387
90Lysine degradation_Homo sapiens_hsa003100.86594008
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86094099
92beta-Alanine metabolism_Homo sapiens_hsa004100.85989272
93Parkinsons disease_Homo sapiens_hsa050120.85532502
94Gastric acid secretion_Homo sapiens_hsa049710.85234070
95ECM-receptor interaction_Homo sapiens_hsa045120.85148759
96Dorso-ventral axis formation_Homo sapiens_hsa043200.84633798
97Huntingtons disease_Homo sapiens_hsa050160.84157640
98Arginine and proline metabolism_Homo sapiens_hsa003300.82363281
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80697735
100Rap1 signaling pathway_Homo sapiens_hsa040150.80097873
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78609584
102African trypanosomiasis_Homo sapiens_hsa051430.78158578
103Sulfur metabolism_Homo sapiens_hsa009200.77695511
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76343982
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76143505
106Type I diabetes mellitus_Homo sapiens_hsa049400.75072332
107Amoebiasis_Homo sapiens_hsa051460.74963972
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.73856013
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73422770
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72892109
111Linoleic acid metabolism_Homo sapiens_hsa005910.71938844
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71887785
113Colorectal cancer_Homo sapiens_hsa052100.71606973
114One carbon pool by folate_Homo sapiens_hsa006700.70531365
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.69993216
116ErbB signaling pathway_Homo sapiens_hsa040120.69503564
117Oxidative phosphorylation_Homo sapiens_hsa001900.68221039
118Ras signaling pathway_Homo sapiens_hsa040140.68035706
119Glucagon signaling pathway_Homo sapiens_hsa049220.66694046
120Synaptic vesicle cycle_Homo sapiens_hsa047210.66322517
121Collecting duct acid secretion_Homo sapiens_hsa049660.64981372
122Hippo signaling pathway_Homo sapiens_hsa043900.64286521
123Proteoglycans in cancer_Homo sapiens_hsa052050.64272792
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.63035272
125Fat digestion and absorption_Homo sapiens_hsa049750.62561715
126Tryptophan metabolism_Homo sapiens_hsa003800.61854148
127Autoimmune thyroid disease_Homo sapiens_hsa053200.61592920
128Olfactory transduction_Homo sapiens_hsa047400.61294899
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60592644
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57760120
131Wnt signaling pathway_Homo sapiens_hsa043100.56661557
132Calcium signaling pathway_Homo sapiens_hsa040200.55454011
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54852225
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54482674
135Taste transduction_Homo sapiens_hsa047420.53977586
136Metabolic pathways_Homo sapiens_hsa011000.53489100
137Folate biosynthesis_Homo sapiens_hsa007900.52761186
138TGF-beta signaling pathway_Homo sapiens_hsa043500.52650757
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52524068
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51745680
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50874723
142AMPK signaling pathway_Homo sapiens_hsa041520.49094024
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48713827
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48229414
145Fatty acid metabolism_Homo sapiens_hsa012120.44611707
146Arginine biosynthesis_Homo sapiens_hsa002200.43611315
147Vitamin B6 metabolism_Homo sapiens_hsa007500.43397258
148Pathways in cancer_Homo sapiens_hsa052000.42472210
149Cardiac muscle contraction_Homo sapiens_hsa042600.40985176
150Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39864940
151Vitamin digestion and absorption_Homo sapiens_hsa049770.39713361
152Starch and sucrose metabolism_Homo sapiens_hsa005000.38450127
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36992207
154Rheumatoid arthritis_Homo sapiens_hsa053230.36750941
155Graft-versus-host disease_Homo sapiens_hsa053320.35742432
156Adherens junction_Homo sapiens_hsa045200.35330953
157Protein digestion and absorption_Homo sapiens_hsa049740.35266587
158Focal adhesion_Homo sapiens_hsa045100.33650767
159Pancreatic secretion_Homo sapiens_hsa049720.33530575
160N-Glycan biosynthesis_Homo sapiens_hsa005100.33312304
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.32761809
162Alzheimers disease_Homo sapiens_hsa050100.31655839
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31378540
164Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30706164
165Tight junction_Homo sapiens_hsa045300.30326244
166Insulin resistance_Homo sapiens_hsa049310.29386823
167Fatty acid degradation_Homo sapiens_hsa000710.25997302
168Regulation of autophagy_Homo sapiens_hsa041400.23063785
169Phenylalanine metabolism_Homo sapiens_hsa003600.21915016
170Sphingolipid metabolism_Homo sapiens_hsa006000.21452408
171Legionellosis_Homo sapiens_hsa051340.20924112
172Epstein-Barr virus infection_Homo sapiens_hsa051690.18083624

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