GPR52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K48-linked deubiquitination (GO:0071108)6.09918270
2monoubiquitinated protein deubiquitination (GO:0035520)5.42572561
3nuclear pore complex assembly (GO:0051292)4.99258240
4regulation of pigment cell differentiation (GO:0050932)4.89393462
5attachment of spindle microtubules to kinetochore (GO:0008608)4.87386830
6positive regulation of developmental pigmentation (GO:0048087)4.84385927
7regulation of B cell receptor signaling pathway (GO:0050855)4.76613249
8histone mRNA catabolic process (GO:0071044)4.73515661
9phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.57921043
10protein K11-linked deubiquitination (GO:0035871)4.37343467
11cellular response to ethanol (GO:0071361)4.21464528
12nuclear pore organization (GO:0006999)4.21201216
13positive regulation of DNA-templated transcription, initiation (GO:2000144)4.18956451
14B cell receptor signaling pathway (GO:0050853)4.16870138
15regulation of cilium movement (GO:0003352)4.12834848
16positive regulation of gamma-delta T cell activation (GO:0046645)4.08441700
17microtubule anchoring (GO:0034453)3.99836268
18positive T cell selection (GO:0043368)3.95846630
19synaptic vesicle endocytosis (GO:0048488)3.83964338
20Peyers patch development (GO:0048541)3.82447774
21mucosal-associated lymphoid tissue development (GO:0048537)3.82447774
22establishment of mitotic spindle orientation (GO:0000132)3.79663057
23negative regulation of DNA repair (GO:0045738)3.75035655
24pore complex assembly (GO:0046931)3.70802183
25mitotic sister chromatid segregation (GO:0000070)3.68478771
26establishment of protein localization to Golgi (GO:0072600)3.66261140
27hepatocyte apoptotic process (GO:0097284)3.60879019
28histone-serine phosphorylation (GO:0035404)3.60593794
29establishment of spindle orientation (GO:0051294)3.60547494
30sister chromatid segregation (GO:0000819)3.59059131
31histone H3-K4 trimethylation (GO:0080182)3.57738546
32cytoplasmic mRNA processing body assembly (GO:0033962)3.55811179
33establishment of mitotic spindle localization (GO:0040001)3.51338954
34establishment of spindle localization (GO:0051293)3.37622746
35histone H3-K36 demethylation (GO:0070544)3.35611832
36positive regulation of growth hormone secretion (GO:0060124)3.28130317
37regulation of establishment of cell polarity (GO:2000114)3.23865762
38protein K63-linked deubiquitination (GO:0070536)3.22975355
39regulation of necroptotic process (GO:0060544)3.20905655
40negative T cell selection (GO:0043383)3.20900177
41positive regulation of dendritic spine morphogenesis (GO:0061003)3.19812060
42regulation of gamma-delta T cell differentiation (GO:0045586)3.18256463
43positive regulation of granulocyte differentiation (GO:0030854)3.17330434
44negative thymic T cell selection (GO:0045060)3.08152700
45protein targeting to Golgi (GO:0000042)3.06639508
46peptidyl-lysine trimethylation (GO:0018023)3.06409190
47interkinetic nuclear migration (GO:0022027)3.06408638
48activated T cell proliferation (GO:0050798)3.06253340
49otic vesicle formation (GO:0030916)3.03847450
50positive thymic T cell selection (GO:0045059)3.03558857
51regulation of meiosis I (GO:0060631)3.03087920
52centrosome localization (GO:0051642)3.02867142
53regulation of gamma-delta T cell activation (GO:0046643)3.00812160
54cerebellar Purkinje cell differentiation (GO:0021702)2.99675834
55determination of adult lifespan (GO:0008340)2.98463666
56retrograde transport, vesicle recycling within Golgi (GO:0000301)2.97741554
57deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.94359902
58regulation of mRNA catabolic process (GO:0061013)2.93383308
59regulation of inositol phosphate biosynthetic process (GO:0010919)2.91578046
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91164337
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88463597
62regulation of protein polyubiquitination (GO:1902914)2.85792816
63Golgi to endosome transport (GO:0006895)2.85562267
64negative regulation of meiosis (GO:0045835)2.85468584
65positive regulation of mRNA catabolic process (GO:0061014)2.82052580
66B cell proliferation (GO:0042100)2.80801892
67mitochondrial DNA replication (GO:0006264)2.78579970
68microglial cell activation (GO:0001774)2.76956394
69establishment of nucleus localization (GO:0040023)2.74747415
70gamma-aminobutyric acid transport (GO:0015812)2.74122181
71nucleus localization (GO:0051647)2.72113171
72regulation of growth hormone secretion (GO:0060123)2.71330497
73negative regulation of B cell proliferation (GO:0030889)2.70604125
74protein prenylation (GO:0018342)2.69771517
75prenylation (GO:0097354)2.69771517
76protein deubiquitination (GO:0016579)2.69360843
77regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.68047347
78positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.68047347
79sister chromatid cohesion (GO:0007062)2.67278087
80positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67160042
81negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.66692548
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65915570
83regulation of DNA-templated transcription, initiation (GO:2000142)2.65534178
84spleen development (GO:0048536)2.63507361
85neuronal action potential propagation (GO:0019227)2.61808404
86macroautophagy (GO:0016236)2.61281072
87dosage compensation (GO:0007549)2.61128300
88necrotic cell death (GO:0070265)2.60710933
89polyol catabolic process (GO:0046174)2.60449454
90positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.59044659
91phospholipid translocation (GO:0045332)2.57479045
92lipid translocation (GO:0034204)2.57479045
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.57456006
94snRNA transcription (GO:0009301)2.56347484
95nerve growth factor signaling pathway (GO:0038180)2.56249351
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55941541
97regulation of MHC class I biosynthetic process (GO:0045343)2.54854322
98regulation of voltage-gated calcium channel activity (GO:1901385)2.54195806
99peptidyl-lysine methylation (GO:0018022)2.53991754
100negative regulation of osteoblast proliferation (GO:0033689)2.53765607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.81540533
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56763502
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.45423889
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80870377
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.75319672
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72419656
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62451073
8GBX2_23144817_ChIP-Seq_PC3_Human2.45351201
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.42712253
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40760999
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.40540101
12E2F7_22180533_ChIP-Seq_HELA_Human2.34668045
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22450384
14TAF15_26573619_Chip-Seq_HEK293_Human2.18867958
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.17600535
16TP53_16413492_ChIP-PET_HCT116_Human2.08946648
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08703177
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.03633302
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02800900
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90020992
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77398004
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76134801
23STAT3_23295773_ChIP-Seq_U87_Human1.76125340
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74768032
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74500530
26RUNX_20019798_ChIP-Seq_JUKART_Human1.73183714
27FUS_26573619_Chip-Seq_HEK293_Human1.73031695
28* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71976539
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67309528
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65587561
31* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65034681
32* ER_23166858_ChIP-Seq_MCF-7_Human1.63889038
33* NFE2_27457419_Chip-Seq_LIVER_Mouse1.61908038
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60819442
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60637386
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59581760
37* EZH2_27294783_Chip-Seq_NPCs_Mouse1.59566185
38* NANOG_18555785_Chip-Seq_ESCs_Mouse1.59045717
39EWS_26573619_Chip-Seq_HEK293_Human1.57637725
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57071529
41IGF1R_20145208_ChIP-Seq_DFB_Human1.55539255
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51775744
43SMAD4_21799915_ChIP-Seq_A2780_Human1.50760496
44* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49648147
45P300_19829295_ChIP-Seq_ESCs_Human1.46466497
46TCF4_23295773_ChIP-Seq_U87_Human1.43267301
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40084643
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39774681
49* E2F1_18555785_Chip-Seq_ESCs_Mouse1.36516115
50MYB_26560356_Chip-Seq_TH2_Human1.34282207
51EZH2_22144423_ChIP-Seq_EOC_Human1.33862388
52* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33393874
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33048064
54CBP_20019798_ChIP-Seq_JUKART_Human1.32920254
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32920254
56* CMYC_18555785_Chip-Seq_ESCs_Mouse1.32015948
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.30686239
58* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29908752
59* P53_22387025_ChIP-Seq_ESCs_Mouse1.29710725
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.29361225
61SCL_19346495_ChIP-Seq_HPC-7_Human1.26936785
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.24790253
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.24743580
64VDR_22108803_ChIP-Seq_LS180_Human1.23908525
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23528787
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22480995
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22480995
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21431053
69* NMYC_18555785_Chip-Seq_ESCs_Mouse1.20985719
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19933282
71* CRX_20693478_ChIP-Seq_RETINA_Mouse1.18290127
72* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18276898
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18231665
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17771830
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.17527003
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16151491
77* P300_18555785_Chip-Seq_ESCs_Mouse1.15838738
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15565230
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14968654
80* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13904215
81AHR_22903824_ChIP-Seq_MCF-7_Human1.13217373
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12696955
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10480348
84* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10441782
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10389666
86* STAT3_18555785_Chip-Seq_ESCs_Mouse1.10374296
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08873220
88AR_25329375_ChIP-Seq_VCAP_Human1.08743710
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08176046
90* OCT4_18555785_Chip-Seq_ESCs_Mouse1.08036087
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.07323514
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.06286893
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05075302
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04384379
95* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03870866
96GATA3_27048872_Chip-Seq_THYMUS_Human1.03552012
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03477909
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03477909
99* KDM2B_26808549_Chip-Seq_REH_Human1.02245509
100* SOX2_18555785_Chip-Seq_ESCs_Mouse1.02127856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.06132208
2MP0008057_abnormal_DNA_replication5.37539379
3MP0003806_abnormal_nucleotide_metabolis3.46922659
4MP0008260_abnormal_autophagy3.24166007
5MP0000015_abnormal_ear_pigmentation2.82494475
6MP0003763_abnormal_thymus_physiology2.72862906
7MP0003656_abnormal_erythrocyte_physiolo2.35468858
8MP0002102_abnormal_ear_morphology2.19357333
9MP0005408_hypopigmentation2.14523480
10MP0004381_abnormal_hair_follicle2.10496353
11MP0003787_abnormal_imprinting2.09496534
12MP0001835_abnormal_antigen_presentation2.02115150
13MP0000372_irregular_coat_pigmentation2.01784479
14MP0003950_abnormal_plasma_membrane1.96950476
15MP0005310_abnormal_salivary_gland1.89463008
16MP0005645_abnormal_hypothalamus_physiol1.88955318
17MP0001800_abnormal_humoral_immune1.87465672
18MP0001501_abnormal_sleep_pattern1.82022907
19MP0005075_abnormal_melanosome_morpholog1.80163928
20MP0005671_abnormal_response_to1.79086526
21MP0002396_abnormal_hematopoietic_system1.76278254
22MP0003866_abnormal_defecation1.68778220
23MP0005266_abnormal_metabolism1.64531848
24MP0000371_diluted_coat_color1.62076073
25MP0002009_preneoplasia1.61425310
26MP0008877_abnormal_DNA_methylation1.56235528
27MP0005174_abnormal_tail_pigmentation1.55969313
28MP0002166_altered_tumor_susceptibility1.54692950
29MP0004147_increased_porphyrin_level1.52599730
30MP0005451_abnormal_body_composition1.52410455
31MP0009697_abnormal_copulation1.51990298
32MP0003221_abnormal_cardiomyocyte_apopto1.46437857
33MP0010386_abnormal_urinary_bladder1.44835854
34MP0000685_abnormal_immune_system1.42430891
35MP0002398_abnormal_bone_marrow1.36197461
36MP0003632_abnormal_nervous_system1.33994927
37MP0005423_abnormal_somatic_nervous1.33125217
38MP0003690_abnormal_glial_cell1.30086848
39MP0002909_abnormal_adrenal_gland1.24285202
40MP0009046_muscle_twitch1.22034119
41MP0002420_abnormal_adaptive_immunity1.20552647
42MP0002095_abnormal_skin_pigmentation1.18888845
43MP0002332_abnormal_exercise_endurance1.18570601
44MP0004859_abnormal_synaptic_plasticity1.17547542
45MP0005171_absent_coat_pigmentation1.17519042
46MP0005187_abnormal_penis_morphology1.17487066
47MP0000689_abnormal_spleen_morphology1.16054661
48MP0001819_abnormal_immune_cell1.15429304
49MP0000703_abnormal_thymus_morphology1.14574778
50MP0000427_abnormal_hair_cycle1.13360793
51MP0002452_abnormal_antigen_presenting1.13110738
52MP0002723_abnormal_immune_serum1.11071496
53MP0003183_abnormal_peptide_metabolism1.10363223
54MP0000716_abnormal_immune_system1.10031498
55MP0005386_behavior/neurological_phenoty1.05212741
56MP0004924_abnormal_behavior1.05212741
57MP0002272_abnormal_nervous_system1.02388557
58MP0002722_abnormal_immune_system1.01796075
59MP0004808_abnormal_hematopoietic_stem1.01764518
60MP0003091_abnormal_cell_migration0.99428732
61MP0003045_fibrosis0.97868709
62MP0010094_abnormal_chromosome_stability0.96908503
63MP0002877_abnormal_melanocyte_morpholog0.95705862
64MP0003724_increased_susceptibility_to0.94681938
65MP0002006_tumorigenesis0.91855253
66MP0003631_nervous_system_phenotype0.89915444
67MP0004883_abnormal_blood_vessel0.89893583
68MP0003077_abnormal_cell_cycle0.89761438
69MP0001790_abnormal_immune_system0.88428614
70MP0005387_immune_system_phenotype0.88428614
71MP0009745_abnormal_behavioral_response0.88399971
72MP0003635_abnormal_synaptic_transmissio0.88072179
73MP0002822_catalepsy0.86876402
74MP0005376_homeostasis/metabolism_phenot0.84930589
75MP0009115_abnormal_fat_cell0.84741280
76MP0003646_muscle_fatigue0.82795273
77MP0002405_respiratory_system_inflammati0.82093882
78MP0003172_abnormal_lysosome_physiology0.81919879
79MP0002429_abnormal_blood_cell0.81696085
80MP0004484_altered_response_of0.81369334
81MP0005000_abnormal_immune_tolerance0.80440257
82MP0005621_abnormal_cell_physiology0.79317848
83MP0005647_abnormal_sex_gland0.79261975
84MP0008058_abnormal_DNA_repair0.77810967
85MP0005551_abnormal_eye_electrophysiolog0.76573111
86MP0005248_abnormal_Harderian_gland0.75884146
87MP0009785_altered_susceptibility_to0.75701472
88MP0002067_abnormal_sensory_capabilities0.75661795
89MP0000465_gastrointestinal_hemorrhage0.75507818
90MP0002419_abnormal_innate_immunity0.75262350
91MP0002019_abnormal_tumor_incidence0.74236955
92MP0003890_abnormal_embryonic-extraembry0.73497739
93MP0003121_genomic_imprinting0.73102587
94MP0010307_abnormal_tumor_latency0.72574324
95MP0003868_abnormal_feces_composition0.72424275
96MP0002064_seizures0.71785704
97MP0006035_abnormal_mitochondrial_morpho0.70247300
98MP0003303_peritoneal_inflammation0.69311764
99MP0001191_abnormal_skin_condition0.66570037
100MP0002075_abnormal_coat/hair_pigmentati0.66343742

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.40994192
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47548428
3Gaze-evoked nystagmus (HP:0000640)4.30644877
4T lymphocytopenia (HP:0005403)4.13302794
5Abnormality of T cell number (HP:0011839)3.68089487
6Progressive inability to walk (HP:0002505)3.36653221
7Progressive external ophthalmoplegia (HP:0000590)3.21212300
8Fair hair (HP:0002286)3.16916344
9Poikilocytosis (HP:0004447)3.14951727
10Bilateral sensorineural hearing impairment (HP:0008619)3.12803816
11Febrile seizures (HP:0002373)3.10778286
12Inability to walk (HP:0002540)3.05275706
13Hyperventilation (HP:0002883)3.03798887
14Papillary thyroid carcinoma (HP:0002895)3.02806831
15Abnormality of the renal cortex (HP:0011035)2.98894713
16Slow saccadic eye movements (HP:0000514)2.93901127
17Acanthocytosis (HP:0001927)2.93001874
18Inappropriate behavior (HP:0000719)2.89286976
19Submucous cleft hard palate (HP:0000176)2.87648238
20Dysmetric saccades (HP:0000641)2.87309238
21Blue irides (HP:0000635)2.86324074
22Generalized hypopigmentation of hair (HP:0011358)2.82289895
23Colitis (HP:0002583)2.77157943
24IgA deficiency (HP:0002720)2.74889501
25Postural instability (HP:0002172)2.69360126
26Genetic anticipation (HP:0003743)2.65684685
27Renal cortical cysts (HP:0000803)2.62704719
28Papilledema (HP:0001085)2.50523793
29Impaired vibratory sensation (HP:0002495)2.45604177
30Protruding tongue (HP:0010808)2.44776967
31Recurrent bacterial skin infections (HP:0005406)2.44743302
32IgM deficiency (HP:0002850)2.39958518
33Sensory axonal neuropathy (HP:0003390)2.39912432
34Progressive cerebellar ataxia (HP:0002073)2.36323621
35Oligodactyly (hands) (HP:0001180)2.35253285
36Drooling (HP:0002307)2.34584223
37Poor eye contact (HP:0000817)2.32136672
38Prominent nose (HP:0000448)2.31928117
39Widely spaced teeth (HP:0000687)2.30622808
40Acute hepatic failure (HP:0006554)2.29246472
41Disinhibition (HP:0000734)2.27771394
42Urinary bladder sphincter dysfunction (HP:0002839)2.27596517
43Excessive salivation (HP:0003781)2.25383092
44Recurrent bronchitis (HP:0002837)2.23524820
45Urethral obstruction (HP:0000796)2.23244329
46Acute myeloid leukemia (HP:0004808)2.19615531
47Recurrent cutaneous fungal infections (HP:0011370)2.18447080
48Chronic mucocutaneous candidiasis (HP:0002728)2.18447080
49Abnormality of the fingertips (HP:0001211)2.17512116
50Abnormality of T cells (HP:0002843)2.14314204
51Subacute progressive viral hepatitis (HP:0006572)2.14233910
52Keratoconjunctivitis (HP:0001096)2.12411866
53Abnormality of salivation (HP:0100755)2.11991881
54Autoimmune hemolytic anemia (HP:0001890)2.11905863
55Recurrent viral infections (HP:0004429)2.10725251
56Hypoplasia of the thymus (HP:0000778)2.10311068
57Absent speech (HP:0001344)2.07759277
58Keratoconjunctivitis sicca (HP:0001097)2.07335498
59Sandal gap (HP:0001852)2.06792598
60Recurrent skin infections (HP:0001581)2.06770893
61Tubulointerstitial fibrosis (HP:0005576)2.06272287
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.01779788
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01779788
64Viral hepatitis (HP:0006562)2.00815605
65Truncal obesity (HP:0001956)2.00643152
66Thyroiditis (HP:0100646)1.98983489
67Short chin (HP:0000331)1.97777186
68Spastic gait (HP:0002064)1.97100323
69Tinnitus (HP:0000360)1.96776820
70Lower limb muscle weakness (HP:0007340)1.96360176
71Abnormal delayed hypersensitivity skin test (HP:0002963)1.93764269
72Visual hallucinations (HP:0002367)1.93468575
73Inflammation of the large intestine (HP:0002037)1.92166139
74Focal motor seizures (HP:0011153)1.91452234
75Acute lymphatic leukemia (HP:0006721)1.90549218
76Abnormality of saccadic eye movements (HP:0000570)1.89608862
77Xerostomia (HP:0000217)1.88079005
78Action tremor (HP:0002345)1.87503939
79Atonic seizures (HP:0010819)1.87074879
80Abnormality of chromosome stability (HP:0003220)1.85045733
81Aplasia/Hypoplasia of the macula (HP:0008059)1.84871955
82Tented upper lip vermilion (HP:0010804)1.84365619
83Recurrent fungal infections (HP:0002841)1.83845040
84Clumsiness (HP:0002312)1.83471938
85Gingivitis (HP:0000230)1.83131281
86Ocular albinism (HP:0001107)1.81345225
87Chronic diarrhea (HP:0002028)1.80495359
88Long clavicles (HP:0000890)1.79802768
89Poor coordination (HP:0002370)1.79361700
90Spontaneous hematomas (HP:0007420)1.78720481
91Recurrent abscess formation (HP:0002722)1.77520656
92Menstrual irregularities (HP:0000858)1.76745325
93Hypopigmentation of the fundus (HP:0007894)1.76657698
94Tubulointerstitial abnormality (HP:0001969)1.76654991
95Spastic paraplegia (HP:0001258)1.74686400
96Impaired vibration sensation in the lower limbs (HP:0002166)1.74117493
97Mild short stature (HP:0003502)1.72282929
98Tubular atrophy (HP:0000092)1.71981271
99Thyroid carcinoma (HP:0002890)1.71883020
100Mask-like facies (HP:0000298)1.71780230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK24.32999098
2FRK3.20224046
3TYK22.08758747
4RIPK42.06815461
5NEK110.1320984
6ACVR1B1.81717382
7PLK41.81051319
8MAP3K41.71130955
9PLK21.69561360
10BLK1.68275735
11SIK21.46898850
12MAP3K61.45844271
13GRK71.44532219
14CAMKK21.41481500
15TAOK31.40511441
16SGK21.39337079
17PTK2B1.37856074
18BRD41.31318486
19CAMK1D1.30033074
20BMPR21.27034403
21TRPM71.26998730
22AKT31.24322150
23MAPK131.22527920
24CCNB11.20427940
25IKBKE1.19872982
26SYK1.14522326
27CDK121.13498557
28EIF2AK31.08354896
29STK41.07767783
30TEC1.05319751
31BTK1.03274490
32FGR0.99102052
33CAMK1G0.96965710
34TXK0.95736994
35PRKCH0.90875364
36WNK10.90725850
37HCK0.89163568
38MARK30.86478722
39BMPR1B0.85221622
40NEK60.84700064
41MAP4K20.80512267
42GRK60.78521532
43CAMK40.78512483
44SGK30.77337114
45PIK3CG0.74857361
46SGK2230.74772552
47SGK4940.74772552
48RAF10.74752284
49JAK10.74599673
50MKNK20.71937839
51PIM10.70879443
52FGFR30.69356087
53SGK10.65768019
54MAP4K10.65359359
55ITK0.63369651
56ERBB30.63031230
57MELK0.61045635
58FES0.58547753
59UHMK10.58376561
60SCYL20.57599883
61RPS6KB20.57409794
62OBSCN0.57341955
63RPS6KA50.53209992
64MAP3K20.51908218
65GRK50.51431514
66ADRBK10.50481521
67JAK20.48196960
68LYN0.47952925
69MAPK70.47192110
70CAMK2B0.45179444
71PAK30.45010612
72EGFR0.44578004
73RPS6KB10.43648118
74PRKCQ0.42286708
75KSR20.41932547
76ROCK20.41774746
77CSNK1D0.41640424
78JAK30.40409122
79ATM0.39732764
80IRAK40.39206356
81MARK20.38045209
82LCK0.36725380
83STK380.35268114
84MAPKAPK50.34978019
85NEK90.34606316
86CSK0.34213345
87CAMKK10.34061386
88PRKACB0.33444413
89PDGFRB0.32865264
90MAP3K100.30764535
91MAPK100.30668688
92MAP3K140.30041350
93RPS6KA40.29647822
94PRKAA20.28883280
95ERBB20.27431137
96MAPK110.26863719
97PRKCB0.26578817
98TNIK0.25638814
99DYRK1A0.25043905
100KSR10.24682920

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.62634775
2Nicotine addiction_Homo sapiens_hsa050332.32767462
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25994684
4Dorso-ventral axis formation_Homo sapiens_hsa043202.21350847
5Taste transduction_Homo sapiens_hsa047422.15861878
6B cell receptor signaling pathway_Homo sapiens_hsa046622.15465507
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.88310637
8Alcoholism_Homo sapiens_hsa050341.88154172
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85188102
10Primary immunodeficiency_Homo sapiens_hsa053401.74067562
11Long-term potentiation_Homo sapiens_hsa047201.60293989
12T cell receptor signaling pathway_Homo sapiens_hsa046601.57475109
13Non-small cell lung cancer_Homo sapiens_hsa052231.53796124
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50432728
15Non-homologous end-joining_Homo sapiens_hsa034501.48947071
16Glutamatergic synapse_Homo sapiens_hsa047241.43244173
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.41594956
18Inositol phosphate metabolism_Homo sapiens_hsa005621.39600867
19Measles_Homo sapiens_hsa051621.34877775
20Graft-versus-host disease_Homo sapiens_hsa053321.29457379
21Fatty acid biosynthesis_Homo sapiens_hsa000611.28190351
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25072000
23Hepatitis B_Homo sapiens_hsa051611.23933331
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.20412194
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19322329
26Viral carcinogenesis_Homo sapiens_hsa052031.16895424
27FoxO signaling pathway_Homo sapiens_hsa040681.16319043
28Osteoclast differentiation_Homo sapiens_hsa043801.14559437
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11516224
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11404555
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.04736094
32Morphine addiction_Homo sapiens_hsa050321.03352999
33Prolactin signaling pathway_Homo sapiens_hsa049171.02864409
34Leishmaniasis_Homo sapiens_hsa051400.99549810
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97762766
36Fanconi anemia pathway_Homo sapiens_hsa034600.97290081
37Nitrogen metabolism_Homo sapiens_hsa009100.93466424
38Pancreatic cancer_Homo sapiens_hsa052120.92763984
39GnRH signaling pathway_Homo sapiens_hsa049120.91925716
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91351694
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91091470
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.90836415
43Platelet activation_Homo sapiens_hsa046110.90247781
44Long-term depression_Homo sapiens_hsa047300.90019335
45Glioma_Homo sapiens_hsa052140.89801807
46Ether lipid metabolism_Homo sapiens_hsa005650.89331403
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89029245
48Allograft rejection_Homo sapiens_hsa053300.88886640
49Tuberculosis_Homo sapiens_hsa051520.87833296
50Choline metabolism in cancer_Homo sapiens_hsa052310.86278259
51Hepatitis C_Homo sapiens_hsa051600.85787605
52mTOR signaling pathway_Homo sapiens_hsa041500.85264553
53Amphetamine addiction_Homo sapiens_hsa050310.83799193
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82667904
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82663422
56Autoimmune thyroid disease_Homo sapiens_hsa053200.81627856
57Salivary secretion_Homo sapiens_hsa049700.81570781
58Cholinergic synapse_Homo sapiens_hsa047250.80818939
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80801187
60Calcium signaling pathway_Homo sapiens_hsa040200.80049027
61Influenza A_Homo sapiens_hsa051640.79874938
62Acute myeloid leukemia_Homo sapiens_hsa052210.79857985
63MicroRNAs in cancer_Homo sapiens_hsa052060.78847701
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78028773
65Oocyte meiosis_Homo sapiens_hsa041140.77705492
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.75051650
67ErbB signaling pathway_Homo sapiens_hsa040120.74068455
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73741972
69RNA degradation_Homo sapiens_hsa030180.73514715
70Herpes simplex infection_Homo sapiens_hsa051680.73266964
71Regulation of autophagy_Homo sapiens_hsa041400.72969325
72Gastric acid secretion_Homo sapiens_hsa049710.72791963
73Chronic myeloid leukemia_Homo sapiens_hsa052200.72275762
74cAMP signaling pathway_Homo sapiens_hsa040240.72180233
75Renal cell carcinoma_Homo sapiens_hsa052110.71948656
76MAPK signaling pathway_Homo sapiens_hsa040100.71339121
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71309332
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.70625918
79Cell cycle_Homo sapiens_hsa041100.68971205
80Oxytocin signaling pathway_Homo sapiens_hsa049210.68552291
81Linoleic acid metabolism_Homo sapiens_hsa005910.68354772
82TNF signaling pathway_Homo sapiens_hsa046680.68251538
83Prostate cancer_Homo sapiens_hsa052150.67490924
84ABC transporters_Homo sapiens_hsa020100.66268178
85Colorectal cancer_Homo sapiens_hsa052100.65486314
86Olfactory transduction_Homo sapiens_hsa047400.65322354
87Endometrial cancer_Homo sapiens_hsa052130.65277812
88Hematopoietic cell lineage_Homo sapiens_hsa046400.64955213
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.64753720
90GABAergic synapse_Homo sapiens_hsa047270.64227171
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63671520
92Circadian entrainment_Homo sapiens_hsa047130.63178641
93Apoptosis_Homo sapiens_hsa042100.62567641
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58717286
95p53 signaling pathway_Homo sapiens_hsa041150.58681257
96Type II diabetes mellitus_Homo sapiens_hsa049300.57309206
97Chemokine signaling pathway_Homo sapiens_hsa040620.55237338
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55133552
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55073326
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.54792662

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