GPR55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.99486740
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.99486740
3antigen processing and presentation of endogenous antigen (GO:0019883)6.81530715
4negative T cell selection (GO:0043383)5.68905392
5negative thymic T cell selection (GO:0045060)5.59812769
6positive regulation of gamma-delta T cell activation (GO:0046645)5.49839689
7regulation of B cell receptor signaling pathway (GO:0050855)5.45630018
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.41905146
9thymic T cell selection (GO:0045061)5.15818927
10positive thymic T cell selection (GO:0045059)5.08135921
11T cell migration (GO:0072678)5.01218975
12regulation of isotype switching to IgG isotypes (GO:0048302)4.99130160
13response to interleukin-15 (GO:0070672)4.93143652
14cellular response to interleukin-15 (GO:0071350)4.86428361
15tolerance induction (GO:0002507)4.81809056
16T cell selection (GO:0045058)4.78162649
17interferon-gamma production (GO:0032609)4.54893405
18regulation of interleukin-12 biosynthetic process (GO:0045075)4.50182652
19positive T cell selection (GO:0043368)4.49788336
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.49732032
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.43913490
22leukocyte aggregation (GO:0070486)4.36969541
23regulation of gamma-delta T cell differentiation (GO:0045586)4.26965454
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26463058
25negative regulation of cell killing (GO:0031342)4.26463058
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25204858
27neutrophil activation involved in immune response (GO:0002283)4.23260679
28B cell homeostasis (GO:0001782)4.21113059
29positive regulation of immunoglobulin production (GO:0002639)4.18644408
30positive regulation by organism of defense response of other organism involved in symbiotic interact4.15757458
31modulation by symbiont of host immune response (GO:0052553)4.15757458
32positive regulation by symbiont of host defense response (GO:0052509)4.15757458
33modulation by symbiont of host defense response (GO:0052031)4.15757458
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.15757458
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.15757458
36regulation of B cell differentiation (GO:0045577)4.14348513
37B cell receptor signaling pathway (GO:0050853)4.06237678
38regulation of B cell proliferation (GO:0030888)4.05960242
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.05644573
40T cell costimulation (GO:0031295)4.00344079
41regulation of gamma-delta T cell activation (GO:0046643)3.97630291
42lymphocyte costimulation (GO:0031294)3.96865279
43response to type I interferon (GO:0034340)3.89759497
44type I interferon signaling pathway (GO:0060337)3.87522548
45cellular response to type I interferon (GO:0071357)3.87522548
46regulation of T cell tolerance induction (GO:0002664)3.83823245
47immunoglobulin mediated immune response (GO:0016064)3.81736670
48antigen receptor-mediated signaling pathway (GO:0050851)3.71448453
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.70300360
50T cell receptor signaling pathway (GO:0050852)3.66049190
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.65940836
52positive regulation of B cell proliferation (GO:0030890)3.65388081
53regulation of type I interferon-mediated signaling pathway (GO:0060338)3.64561344
54regulation of immunoglobulin production (GO:0002637)3.63063791
55JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.62492059
56detection of bacterium (GO:0016045)3.61870039
57B cell mediated immunity (GO:0019724)3.61650225
58regulation of T cell receptor signaling pathway (GO:0050856)3.59448982
59negative regulation of B cell proliferation (GO:0030889)3.59080079
60positive regulation of B cell differentiation (GO:0045579)3.58047524
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.56840858
62regulation of response to interferon-gamma (GO:0060330)3.56513710
63regulation of alpha-beta T cell proliferation (GO:0046640)3.52391059
64cellular extravasation (GO:0045123)3.51650466
65regulation of interleukin-2 biosynthetic process (GO:0045076)3.51541530
66negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.50707041
67positive regulation of isotype switching (GO:0045830)3.49264889
68regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.47338434
69positive regulation of interleukin-2 production (GO:0032743)3.46176761
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44217989
71mature B cell differentiation (GO:0002335)3.42720395
72positive regulation of B cell activation (GO:0050871)3.42707550
73regulation of T-helper 1 cell differentiation (GO:0045625)3.40580895
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.39968856
75regulation of natural killer cell mediated immunity (GO:0002715)3.39968856
76detection of other organism (GO:0098543)3.39554079
77interferon-gamma-mediated signaling pathway (GO:0060333)3.38934242
78positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.37622078
79positive regulation of natural killer cell mediated immunity (GO:0002717)3.37622078
80megakaryocyte development (GO:0035855)3.37238028
81regulation of B cell activation (GO:0050864)3.36977822
82lymphocyte homeostasis (GO:0002260)3.36540729
83signal peptide processing (GO:0006465)3.35896360
84thrombin receptor signaling pathway (GO:0070493)3.35460376
85NIK/NF-kappaB signaling (GO:0038061)3.35439288
86immune response-activating cell surface receptor signaling pathway (GO:0002429)3.29672863
87positive regulation of humoral immune response (GO:0002922)3.29666129
88response to protozoan (GO:0001562)3.28408563
89defense response to protozoan (GO:0042832)3.26791513
90regulation of platelet aggregation (GO:0090330)3.26042915
91positive regulation of granulocyte differentiation (GO:0030854)3.24723726
92response to muramyl dipeptide (GO:0032495)3.24224480
93tyrosine phosphorylation of STAT protein (GO:0007260)3.19924124
94positive regulation of mast cell activation (GO:0033005)3.19484305
95negative regulation of T cell mediated immunity (GO:0002710)3.19463227
96response to host immune response (GO:0052572)3.17865693
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17865693
98regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.16273899
99positive regulation of alpha-beta T cell proliferation (GO:0046641)3.16001653
100cytidine metabolic process (GO:0046087)3.15530518
101cytidine catabolic process (GO:0006216)3.15530518
102cytidine deamination (GO:0009972)3.15530518
103regulation of B cell mediated immunity (GO:0002712)3.15232292
104cellular response to interferon-beta (GO:0035458)3.14774360
105positive regulation of tolerance induction (GO:0002645)3.14610758
106natural killer cell activation (GO:0030101)3.14066174
107leukocyte cell-cell adhesion (GO:0007159)3.13287891
108regulation of interferon-alpha production (GO:0032647)3.13154489
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12932122
110myeloid dendritic cell activation (GO:0001773)3.09355563
111neutrophil activation (GO:0042119)3.09123734
112cellular response to zinc ion (GO:0071294)3.09061013
113regulation of isotype switching (GO:0045191)3.08938930
114regulation of tolerance induction (GO:0002643)3.08037455
115mast cell activation (GO:0045576)3.07542154
116positive regulation of interleukin-4 production (GO:0032753)3.07488210
117germinal center formation (GO:0002467)3.06891324
118positive regulation of DNA recombination (GO:0045911)3.05935784
119B cell proliferation (GO:0042100)3.04877826
120regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02782357
121T cell lineage commitment (GO:0002360)3.02759457
122Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01364992
123positive regulation of B cell mediated immunity (GO:0002714)2.99842948
124positive regulation of immunoglobulin mediated immune response (GO:0002891)2.99842948
125myeloid dendritic cell differentiation (GO:0043011)2.99766773
126activated T cell proliferation (GO:0050798)2.99399116
127positive regulation of macrophage differentiation (GO:0045651)2.99392568
128T cell differentiation involved in immune response (GO:0002292)2.99055523
129alpha-beta T cell differentiation involved in immune response (GO:0002293)2.99055523
130alpha-beta T cell activation involved in immune response (GO:0002287)2.99055523
131regulation of immunoglobulin mediated immune response (GO:0002889)2.98971212
132antigen processing and presentation via MHC class Ib (GO:0002475)2.98888643
133negative regulation of lymphocyte mediated immunity (GO:0002707)2.97553219
134negative regulation of interleukin-12 production (GO:0032695)2.97456326
135T cell activation involved in immune response (GO:0002286)2.92454906
136regulation of regulatory T cell differentiation (GO:0045589)2.92232691
137regulation of interferon-beta biosynthetic process (GO:0045357)2.91694329
138response to host (GO:0075136)2.90719996
139response to host defenses (GO:0052200)2.90719996
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90719996
141myeloid cell activation involved in immune response (GO:0002275)2.90641745
142leukocyte homeostasis (GO:0001776)2.90164832
143lymphocyte migration (GO:0072676)2.90010621
144regulation of T cell mediated cytotoxicity (GO:0001914)2.89962654
145regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89200624
146regulation of podosome assembly (GO:0071801)2.88660278
147positive regulation of interleukin-12 production (GO:0032735)2.87491322
148negative regulation of erythrocyte differentiation (GO:0045647)2.86236333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.44155858
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.70726151
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.67558503
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.31867259
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.92475238
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76454764
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.75401864
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.47080628
9MYC_22102868_ChIP-Seq_BL_Human3.27229987
10RUNX_20019798_ChIP-Seq_JUKART_Human3.22219989
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19046057
12MYB_26560356_Chip-Seq_TH2_Human3.08832761
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.00864798
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.95783171
15* MAF_26560356_Chip-Seq_TH1_Human2.93780966
16VDR_21846776_ChIP-Seq_THP-1_Human2.65318368
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.64983327
18MYB_26560356_Chip-Seq_TH1_Human2.59875165
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.58383590
20* UTX_26944678_Chip-Seq_JUKART_Human2.31972068
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.31843136
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31358569
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.28115739
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26597167
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.26591534
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19273704
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14126528
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.07384566
29TCF7_22412390_ChIP-Seq_EML_Mouse2.05955186
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05263014
31VDR_24763502_ChIP-Seq_THP-1_Human2.01854938
32MAF_26560356_Chip-Seq_TH2_Human1.97956622
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96067087
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95134802
35* SPI1_23547873_ChIP-Seq_NB4_Human1.93946996
36SCL_19346495_ChIP-Seq_HPC-7_Human1.85856736
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83771858
38GATA3_27048872_Chip-Seq_THYMUS_Human1.81713088
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76734434
40KDM2B_26808549_Chip-Seq_DND41_Human1.73539183
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69931248
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66384742
43E2F7_22180533_ChIP-Seq_HELA_Human1.62299972
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60082069
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.57332077
46CIITA_25753668_ChIP-Seq_RAJI_Human1.56898155
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56389967
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56031003
49SPI1_23127762_ChIP-Seq_K562_Human1.54229989
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53680493
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50793203
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45664436
53GATA3_26560356_Chip-Seq_TH2_Human1.41013536
54* PU_27001747_Chip-Seq_BMDM_Mouse1.37031822
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35261487
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35144985
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33940693
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27885788
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25617953
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23579721
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22003992
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18006242
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17835684
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.16450900
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14392847
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13174426
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12796604
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12663442
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.12263116
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10094193
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09800815
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.04960781
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.04075414
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03151796
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02833689
76VDR_24787735_ChIP-Seq_THP-1_Human1.01309749
77GATA1_22025678_ChIP-Seq_K562_Human1.00963129
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99664968
79CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99296853
80LXR_22292898_ChIP-Seq_THP-1_Human0.98819736
81GATA1_19941827_ChIP-Seq_MEL_Mouse0.96428734
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96286863
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95243591
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95195176
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93458931
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91152323
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89640408
88SPI1_20517297_ChIP-Seq_HL60_Human0.89210790
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88457234
90BCOR_27268052_Chip-Seq_Bcells_Human0.86282544
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84937295
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84488370
93GATA2_19941826_ChIP-Seq_K562_Human0.84351500
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84190001
95EGR1_19032775_ChIP-ChIP_M12_Human0.82366630
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81791030
97NCOR1_26117541_ChIP-Seq_K562_Human0.80778996
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78856596
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77677332
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.77525559
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77296582
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76689640
103SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76594164
104* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76436415
105GATA1_19941826_ChIP-Seq_K562_Human0.71877880
106CTCF_26484167_Chip-Seq_Bcells_Mouse0.71748431
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71641231
108IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70920854
109* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69449234
110BCL6_27268052_Chip-Seq_Bcells_Human0.69240776
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68760214
112RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68447238
113CTCF_21964334_ChIP-Seq_BJAB-B_Human0.68197158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.63956271
2MP0005671_abnormal_response_to4.38827597
3MP0001790_abnormal_immune_system3.69897769
4MP0005387_immune_system_phenotype3.69897769
5MP0001800_abnormal_humoral_immune3.68103131
6MP0003763_abnormal_thymus_physiology3.55943971
7MP0000685_abnormal_immune_system3.18825592
8MP0005000_abnormal_immune_tolerance3.06659780
9* MP0002452_abnormal_antigen_presenting2.94640492
10MP0002723_abnormal_immune_serum2.94435081
11* MP0002420_abnormal_adaptive_immunity2.84522475
12* MP0001819_abnormal_immune_cell2.82645505
13MP0001873_stomach_inflammation2.82444289
14MP0002166_altered_tumor_susceptibility2.80636461
15MP0003303_peritoneal_inflammation2.76768558
16MP0009785_altered_susceptibility_to2.76615719
17MP0005025_abnormal_response_to2.69771746
18MP0002398_abnormal_bone_marrow2.58771829
19MP0003300_gastrointestinal_ulcer2.51037534
20MP0009333_abnormal_splenocyte_physiolog2.50337350
21MP0003436_decreased_susceptibility_to2.47564730
22MP0006082_CNS_inflammation2.43858803
23MP0004510_myositis2.42041488
24MP0002006_tumorigenesis2.41088510
25* MP0000716_abnormal_immune_system2.35695214
26MP0002405_respiratory_system_inflammati2.35503328
27MP0002148_abnormal_hypersensitivity_rea2.32521405
28MP0010155_abnormal_intestine_physiology2.25963603
29MP0004947_skin_inflammation2.11580940
30* MP0002419_abnormal_innate_immunity2.04276453
31MP0000689_abnormal_spleen_morphology2.00514297
32MP0003866_abnormal_defecation1.98762530
33MP0002722_abnormal_immune_system1.97048922
34MP0003045_fibrosis1.92931959
35MP0003724_increased_susceptibility_to1.92345558
36* MP0002429_abnormal_blood_cell1.91397019
37MP0001853_heart_inflammation1.89460912
38MP0001845_abnormal_inflammatory_respons1.84869786
39MP0005310_abnormal_salivary_gland1.84757899
40MP0000703_abnormal_thymus_morphology1.79759141
41MP0008004_abnormal_stomach_pH1.78214698
42MP0005645_abnormal_hypothalamus_physiol1.64490117
43MP0005464_abnormal_platelet_physiology1.56016399
44MP0002933_joint_inflammation1.47395313
45MP0003448_altered_tumor_morphology1.44963143
46MP0002396_abnormal_hematopoietic_system1.27978211
47MP0000858_altered_metastatic_potential1.25040949
48MP0008469_abnormal_protein_level1.24433741
49MP0000490_abnormal_crypts_of1.22457734
50MP0001533_abnormal_skeleton_physiology1.20966246
51MP0004808_abnormal_hematopoietic_stem1.20840537
52MP0005076_abnormal_cell_differentiation1.13046958
53MP0010234_abnormal_vibrissa_follicle1.11460116
54MP0005174_abnormal_tail_pigmentation1.10331469
55MP0008057_abnormal_DNA_replication1.08232210
56MP0000465_gastrointestinal_hemorrhage1.07666656
57MP0004381_abnormal_hair_follicle1.03783665
58MP0005397_hematopoietic_system_phenotyp1.02620614
59MP0001545_abnormal_hematopoietic_system1.02620614
60MP0003828_pulmonary_edema0.97070636
61MP0002019_abnormal_tumor_incidence0.95861952
62MP0002009_preneoplasia0.93378765
63MP0001851_eye_inflammation0.92887758
64MP0008874_decreased_physiological_sensi0.90746749
65MP0010307_abnormal_tumor_latency0.90076226
66MP0008961_abnormal_basal_metabolism0.87504563
67* MP0002998_abnormal_bone_remodeling0.86819697
68MP0009278_abnormal_bone_marrow0.85343451
69MP0001663_abnormal_digestive_system0.84876810
70MP0005623_abnormal_meninges_morphology0.84032148
71MP0005451_abnormal_body_composition0.82110957
72MP0003566_abnormal_cell_adhesion0.81981242
73MP0008260_abnormal_autophagy0.80777582
74MP0003453_abnormal_keratinocyte_physiol0.79781892
75MP0000343_altered_response_to0.78323409
76MP0005166_decreased_susceptibility_to0.76371340
77MP0009764_decreased_sensitivity_to0.76117590
78MP0002138_abnormal_hepatobiliary_system0.75945377
79MP0002822_catalepsy0.73899152
80MP0003183_abnormal_peptide_metabolism0.73538348
81MP0010352_gastrointestinal_tract_polyps0.72470201
82MP0003656_abnormal_erythrocyte_physiolo0.70089379
83MP0000477_abnormal_intestine_morphology0.69877431
84MP0003172_abnormal_lysosome_physiology0.68674886
85MP0002136_abnormal_kidney_physiology0.67956743
86MP0002163_abnormal_gland_morphology0.67206501
87MP0008877_abnormal_DNA_methylation0.67099844
88MP0004264_abnormal_extraembryonic_tissu0.66757483
89MP0005023_abnormal_wound_healing0.66458149
90MP0002693_abnormal_pancreas_physiology0.66402944
91MP0009765_abnormal_xenobiotic_induced0.64103201
92MP0003191_abnormal_cellular_cholesterol0.63874196
93MP0002168_other_aberrant_phenotype0.62621146
94MP0009763_increased_sensitivity_to0.62377820
95MP0003878_abnormal_ear_physiology0.61193094
96MP0005377_hearing/vestibular/ear_phenot0.61193094
97MP0005058_abnormal_lysosome_morphology0.60247518
98MP0001191_abnormal_skin_condition0.59454771
99MP0008995_early_reproductive_senescence0.57342273
100MP0010094_abnormal_chromosome_stability0.56930489
101MP0005084_abnormal_gallbladder_morpholo0.56625900
102MP0000609_abnormal_liver_physiology0.55523138
103MP0009642_abnormal_blood_homeostasis0.55456778
104MP0005621_abnormal_cell_physiology0.55285638
105MP0009840_abnormal_foam_cell0.54891619
106MP0002132_abnormal_respiratory_system0.54165749
107MP0000249_abnormal_blood_vessel0.53726112
108MP0005167_abnormal_blood-brain_barrier0.52250971
109MP0001881_abnormal_mammary_gland0.51992194
110MP0001348_abnormal_lacrimal_gland0.49767698
111MP0006035_abnormal_mitochondrial_morpho0.48424894
112MP0000015_abnormal_ear_pigmentation0.47626970
113MP0003075_altered_response_to0.47518298
114MP0009115_abnormal_fat_cell0.47372615
115MP0003091_abnormal_cell_migration0.46989119
116* MP0003795_abnormal_bone_structure0.45795546
117MP0005390_skeleton_phenotype0.45366219
118MP0005381_digestive/alimentary_phenotyp0.44006385
119MP0005083_abnormal_biliary_tract0.43835783
120MP0005075_abnormal_melanosome_morpholog0.43814259
121MP0001216_abnormal_epidermal_layer0.43203678
122MP0000313_abnormal_cell_death0.42787918
123MP0004883_abnormal_blood_vessel0.42437042

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)5.92466471
2IgM deficiency (HP:0002850)5.64528658
3Menorrhagia (HP:0000132)5.45816693
4Increased mean platelet volume (HP:0011877)5.24644072
5Epistaxis (HP:0000421)5.11026445
6Purpura (HP:0000979)5.07813965
7B lymphocytopenia (HP:0010976)5.05984007
8Abnormality of B cell number (HP:0010975)5.05984007
9Recurrent viral infections (HP:0004429)5.00067620
10Agammaglobulinemia (HP:0004432)4.72697490
11Recurrent fungal infections (HP:0002841)4.69746394
12Nasal polyposis (HP:0100582)4.60370401
13Recurrent sinusitis (HP:0011108)4.58735477
14Chronic otitis media (HP:0000389)4.56382286
15Recurrent cutaneous fungal infections (HP:0011370)4.43335920
16Chronic mucocutaneous candidiasis (HP:0002728)4.43335920
17Myositis (HP:0100614)4.40410687
18Inflammation of the large intestine (HP:0002037)4.35257277
19Abnormality of T cell number (HP:0011839)4.18704429
20Retrobulbar optic neuritis (HP:0100654)4.17754040
21Optic neuritis (HP:0100653)4.17754040
22Eczematoid dermatitis (HP:0000976)4.17547634
23T lymphocytopenia (HP:0005403)4.17511608
24Gastrointestinal inflammation (HP:0004386)4.11327652
25Meningitis (HP:0001287)4.06328926
26Elevated erythrocyte sedimentation rate (HP:0003565)4.05301286
27Colitis (HP:0002583)4.04475495
28Abnormality of T cells (HP:0002843)4.00961644
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.98523211
30Recurrent abscess formation (HP:0002722)3.86105591
31Vasculitis (HP:0002633)3.81015966
32Abnormality of the nasal mucosa (HP:0000433)3.80931327
33Orchitis (HP:0100796)3.78904937
34Abnormality of T cell physiology (HP:0011840)3.76421588
35Pustule (HP:0200039)3.69608588
36IgG deficiency (HP:0004315)3.58561232
37Gastrointestinal stroma tumor (HP:0100723)3.55020016
38Abnormal platelet function (HP:0011869)3.53735559
39Impaired platelet aggregation (HP:0003540)3.53735559
40IgA deficiency (HP:0002720)3.51135842
41Bronchitis (HP:0012387)3.44697004
42Chronic diarrhea (HP:0002028)3.42946007
43Panhypogammaglobulinemia (HP:0003139)3.42758966
44Mediastinal lymphadenopathy (HP:0100721)3.38905799
45Severe combined immunodeficiency (HP:0004430)3.38645038
46Cellulitis (HP:0100658)3.36439375
47Hyperlipoproteinemia (HP:0010980)3.30401047
48Lymphopenia (HP:0001888)3.30317962
49Recurrent bacterial skin infections (HP:0005406)3.29072502
50Recurrent skin infections (HP:0001581)3.24621828
51Abnormality of cells of the lymphoid lineage (HP:0012140)3.21881896
52Pulmonary infiltrates (HP:0002113)3.19322003
53Combined immunodeficiency (HP:0005387)3.19286307
54Increased IgM level (HP:0003496)3.15481015
55Obstructive lung disease (HP:0006536)3.12874063
56Chronic obstructive pulmonary disease (HP:0006510)3.12874063
57Increased IgE level (HP:0003212)3.11400946
58Hemoptysis (HP:0002105)3.09134016
59Verrucae (HP:0200043)3.07910940
60Papilloma (HP:0012740)3.07910940
61Autoimmune thrombocytopenia (HP:0001973)3.00551232
62Thyroiditis (HP:0100646)2.98965841
63Stomatitis (HP:0010280)2.96848465
64Chronic sinusitis (HP:0011109)2.96793229
65Autoimmune hemolytic anemia (HP:0001890)2.85316057
66Recurrent pneumonia (HP:0006532)2.83607997
67Arterial thrombosis (HP:0004420)2.79893851
68Encephalitis (HP:0002383)2.78261359
69Abnormality of the fingertips (HP:0001211)2.77099024
70Hypergammaglobulinemia (HP:0010702)2.75957803
71Recurrent otitis media (HP:0000403)2.69227064
72Cheilitis (HP:0100825)2.68673133
73Emphysema (HP:0002097)2.67899318
74Keratoconjunctivitis sicca (HP:0001097)2.66685398
75Increased density of long bones (HP:0006392)2.58223664
76Gastrointestinal infarctions (HP:0005244)2.55762836
77Recurrent lower respiratory tract infections (HP:0002783)2.54511210
78Abnormality of eosinophils (HP:0001879)2.51702056
79Fatigue (HP:0012378)2.51540491
80Granulocytopenia (HP:0001913)2.48900969
81Arthralgia (HP:0002829)2.45000090
82Basal cell carcinoma (HP:0002671)2.43869670
83Keratoconjunctivitis (HP:0001096)2.42649954
84Hypochromic anemia (HP:0001931)2.42460508
85Acute hepatic failure (HP:0006554)2.37801388
86Petechiae (HP:0000967)2.37356590
87Leukocytosis (HP:0001974)2.35130950
88Abnormality of macrophages (HP:0004311)2.34525259
89Bronchiectasis (HP:0002110)2.32458659
90Recurrent gram-negative bacterial infections (HP:0005420)2.30416384
91Restrictive lung disease (HP:0002091)2.29870276
92Skin rash (HP:0000988)2.29062039
93Joint swelling (HP:0001386)2.24781511
94Dyschromatopsia (HP:0007641)2.24570355
95Hepatosplenomegaly (HP:0001433)2.21793409
96Poikiloderma (HP:0001029)2.21248733
97Eosinophilia (HP:0001880)2.21055244
98Interstitial pulmonary disease (HP:0006530)2.20210309
99Thrombocytosis (HP:0001894)2.20024026
100Osteomyelitis (HP:0002754)2.19919377
101Pulmonary embolism (HP:0002204)2.19005720
102Lymphoma (HP:0002665)2.18802564
103Chest pain (HP:0100749)2.17833083
104Abnormality of the prostate (HP:0008775)2.14723344
105Sepsis (HP:0100806)2.14570779
106Urticaria (HP:0001025)2.12825436
107Skin ulcer (HP:0200042)2.12635532
108Spontaneous hematomas (HP:0007420)2.11640567
109Gangrene (HP:0100758)2.10389476
110Viral hepatitis (HP:0006562)2.08498396
111Abnormality of lateral ventricle (HP:0030047)2.08439974
112Abnormal platelet volume (HP:0011876)2.07833643
113Hypertensive crisis (HP:0100735)2.07360020
114Gingival bleeding (HP:0000225)2.06672544
115Gingivitis (HP:0000230)2.06591547
116Polyneuropathy (HP:0001271)2.05229211
117Abnormality of the common coagulation pathway (HP:0010990)2.01376285
118Prolonged bleeding time (HP:0003010)2.00941925
119Amaurosis fugax (HP:0100576)2.00061265
120Bruising susceptibility (HP:0000978)1.99032817
121Pulmonary fibrosis (HP:0002206)1.97157282
122Abnormal pupillary function (HP:0007686)1.95564940
123Acanthocytosis (HP:0001927)1.90946738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.43137901
2TXK4.90722764
3PRPF4B3.91150693
4TYK23.45446284
5IKBKE3.27434431
6JAK33.23671411
7FGFR43.20242475
8JAK12.54110408
9MAP3K142.50742116
10TBK12.44716791
11KIT2.43675222
12FGFR32.23371651
13ITK2.21527052
14BMPR22.15374994
15GRK62.11196219
16IRAK42.05758481
17ZAP701.93191154
18STK101.73385297
19ERN11.70387797
20SYK1.68677384
21BTK1.61627265
22IKBKB1.57028826
23BLK1.55203779
24CSK1.54942758
25TAOK31.54488967
26LCK1.54038994
27IRAK31.51655501
28CSF1R1.38290428
29TEC1.32619203
30SMG11.31277677
31EPHB11.26002572
32SIK21.24231587
33MAP3K131.23748731
34PTK2B1.23576687
35HCK1.22926688
36PIM11.22146275
37PIM21.15405725
38MAP3K101.12199101
39CHUK1.07139506
40MST41.06057816
41LYN1.04405428
42FES1.04255844
43CDK121.02117947
44TAOK21.01483520
45PRKCH1.00251233
46JAK20.99491295
47PASK0.97665869
48PRKCQ0.94468623
49EIF2AK30.93811112
50LRRK20.91441167
51RIPK40.91110083
52MAPK110.86669905
53TNK20.84575698
54NME20.84555566
55MAPK120.83854891
56EEF2K0.83176970
57TRIB30.82723309
58CDC42BPA0.81491670
59SIK30.79693740
60TGFBR20.72492933
61MAP2K30.72133765
62CDK60.71303382
63FGR0.69630397
64CLK10.69267070
65PDK10.68204622
66PIK3CG0.67887279
67DMPK0.67048978
68TNIK0.67029233
69ALK0.59951590
70ARAF0.58635011
71RIPK10.56261034
72TESK20.55954384
73MARK30.55503080
74MAP3K120.54102384
75IRAK20.53838560
76STK240.53763750
77MAP3K50.53540773
78TAOK10.53509152
79RET0.52703762
80BMX0.52592602
81HIPK20.52071859
82PRKD20.51582196
83PDPK10.51153341
84EIF2AK10.50628702
85CDK40.50406603
86CDK90.50278562
87PTK60.50076809
88YES10.48835345
89MATK0.48388244
90RAF10.47779638
91MYLK0.47667171
92STK30.46307092
93NEK20.45113249
94GRK50.44605620
95MAPK70.44068456
96MELK0.43679873
97SIK10.43239153
98EPHA30.42652440
99ILK0.42393775
100NLK0.41896310
101ABL10.41784507
102RPS6KA40.40178870
103PRKG20.39051946
104IRAK10.38239444
105DAPK30.36757005
106PAK10.36430227
107INSR0.35171882
108EGFR0.34659024
109RPS6KA60.33604760
110FYN0.33567236
111TRPM70.33372749
112PKN20.32257836
113TYRO30.31869032
114PRKCI0.31641645
115PRKCD0.31131102
116ICK0.30823531
117NUAK10.29718935
118KDR0.27757159
119TLK10.27535761
120MAPK30.27175596
121PKN10.26296063
122MAP3K80.26248033
123MAPKAPK30.26198233
124DAPK10.25817636
125NEK90.25330414
126MAPKAPK20.24993077
127RPS6KC10.24649993
128RPS6KL10.24649993
129SGK20.24497683
130SGK30.24419460
131RPS6KA50.23394186
132RPS6KA10.22359335
133MAP3K110.22028653
134MAPK40.21810331
135BRD40.21635179
136MAP3K70.20421303

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.52134413
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.12163622
3Allograft rejection_Homo sapiens_hsa053303.62598614
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.43611219
5Asthma_Homo sapiens_hsa053103.18457512
6Graft-versus-host disease_Homo sapiens_hsa053322.78890007
7T cell receptor signaling pathway_Homo sapiens_hsa046602.72668329
8Antigen processing and presentation_Homo sapiens_hsa046122.63287739
9Measles_Homo sapiens_hsa051622.63240700
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.57504140
11B cell receptor signaling pathway_Homo sapiens_hsa046622.50775446
12Autoimmune thyroid disease_Homo sapiens_hsa053202.49937647
13Leishmaniasis_Homo sapiens_hsa051402.41068587
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.33140719
15Osteoclast differentiation_Homo sapiens_hsa043802.08598956
16Jak-STAT signaling pathway_Homo sapiens_hsa046302.01957986
17Hematopoietic cell lineage_Homo sapiens_hsa046401.95830740
18Herpes simplex infection_Homo sapiens_hsa051681.63003115
19Toxoplasmosis_Homo sapiens_hsa051451.62198662
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56055134
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49689208
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47490878
23Viral myocarditis_Homo sapiens_hsa054161.47055957
24Influenza A_Homo sapiens_hsa051641.46050854
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44118607
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39853949
27Chemokine signaling pathway_Homo sapiens_hsa040621.38729429
28Systemic lupus erythematosus_Homo sapiens_hsa053221.32587555
29Hepatitis B_Homo sapiens_hsa051611.25866164
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24287669
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22759740
32Apoptosis_Homo sapiens_hsa042101.16553628
33Tuberculosis_Homo sapiens_hsa051521.15611769
34TNF signaling pathway_Homo sapiens_hsa046681.13790719
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12095168
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.12051831
37Shigellosis_Homo sapiens_hsa051311.11521453
38Legionellosis_Homo sapiens_hsa051341.10083525
39Type I diabetes mellitus_Homo sapiens_hsa049401.06618671
40Malaria_Homo sapiens_hsa051441.01829257
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92969396
42Acute myeloid leukemia_Homo sapiens_hsa052210.89641228
43African trypanosomiasis_Homo sapiens_hsa051430.85890463
44Staphylococcus aureus infection_Homo sapiens_hsa051500.84221078
45Phagosome_Homo sapiens_hsa041450.82874402
46Pancreatic cancer_Homo sapiens_hsa052120.82014009
47Salmonella infection_Homo sapiens_hsa051320.80061035
48Epstein-Barr virus infection_Homo sapiens_hsa051690.79802627
49Hepatitis C_Homo sapiens_hsa051600.78770862
50VEGF signaling pathway_Homo sapiens_hsa043700.78568062
51Prolactin signaling pathway_Homo sapiens_hsa049170.77284443
52Platelet activation_Homo sapiens_hsa046110.77060259
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76014429
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75780166
55Chronic myeloid leukemia_Homo sapiens_hsa052200.75169976
56HTLV-I infection_Homo sapiens_hsa051660.74140334
57Pertussis_Homo sapiens_hsa051330.73449280
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71199449
59Caffeine metabolism_Homo sapiens_hsa002320.69265750
60Other glycan degradation_Homo sapiens_hsa005110.64936844
61Viral carcinogenesis_Homo sapiens_hsa052030.63407236
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.61724768
63Endometrial cancer_Homo sapiens_hsa052130.54680971
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54606622
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53869918
66Small cell lung cancer_Homo sapiens_hsa052220.51587842
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51525836
68p53 signaling pathway_Homo sapiens_hsa041150.51100992
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50517780
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.50449813
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50394954
72Notch signaling pathway_Homo sapiens_hsa043300.50114972
73Rheumatoid arthritis_Homo sapiens_hsa053230.49903697
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49114713
75Renal cell carcinoma_Homo sapiens_hsa052110.47811823
76Ribosome_Homo sapiens_hsa030100.46670268
77Non-small cell lung cancer_Homo sapiens_hsa052230.44669607
78Colorectal cancer_Homo sapiens_hsa052100.43971292
79Choline metabolism in cancer_Homo sapiens_hsa052310.42989574
80Alcoholism_Homo sapiens_hsa050340.41442857
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41264792
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40160364
83MAPK signaling pathway_Homo sapiens_hsa040100.38608556
84Dorso-ventral axis formation_Homo sapiens_hsa043200.38602225
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34512739
86Gap junction_Homo sapiens_hsa045400.32956841
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32165192
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31734718
89Glioma_Homo sapiens_hsa052140.30515620
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30241856
91Endocytosis_Homo sapiens_hsa041440.30065598
92Base excision repair_Homo sapiens_hsa034100.28841979
93Fatty acid biosynthesis_Homo sapiens_hsa000610.28326641
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28168692
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28058502
96Protein export_Homo sapiens_hsa030600.27905046
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27602227
98HIF-1 signaling pathway_Homo sapiens_hsa040660.24448706
99ABC transporters_Homo sapiens_hsa020100.23977575
100GnRH signaling pathway_Homo sapiens_hsa049120.23315752
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22884082
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.22878658
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.21741679
104ErbB signaling pathway_Homo sapiens_hsa040120.21127776
105Type II diabetes mellitus_Homo sapiens_hsa049300.20959837
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.20289786
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.20006887
108MicroRNAs in cancer_Homo sapiens_hsa052060.19663358
109N-Glycan biosynthesis_Homo sapiens_hsa005100.19618660
110Insulin resistance_Homo sapiens_hsa049310.18439630
111Inositol phosphate metabolism_Homo sapiens_hsa005620.17327458
112Rap1 signaling pathway_Homo sapiens_hsa040150.17099059
113Thyroid cancer_Homo sapiens_hsa052160.17090198
114Amoebiasis_Homo sapiens_hsa051460.16827599
115FoxO signaling pathway_Homo sapiens_hsa040680.16443480
116Renin-angiotensin system_Homo sapiens_hsa046140.15901119
117Lysosome_Homo sapiens_hsa041420.15157665
118Pathways in cancer_Homo sapiens_hsa052000.15025223
119Prostate cancer_Homo sapiens_hsa052150.14911967
120Ras signaling pathway_Homo sapiens_hsa040140.14701689
121mTOR signaling pathway_Homo sapiens_hsa041500.13541527

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