GPR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.54426903
2glycerophospholipid catabolic process (GO:0046475)6.76146386
3adaptation of signaling pathway (GO:0023058)6.52113364
4positive regulation of action potential (GO:0045760)6.48951831
5synaptic transmission, dopaminergic (GO:0001963)6.44664288
6regulation of synapse structural plasticity (GO:0051823)6.11320752
7prepulse inhibition (GO:0060134)6.10606918
8establishment of mitochondrion localization (GO:0051654)5.84121081
9pyrimidine nucleobase catabolic process (GO:0006208)5.83080384
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75779415
11locomotory exploration behavior (GO:0035641)5.53992327
12mitochondrion transport along microtubule (GO:0047497)5.49976245
13establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.49976245
14adenosine receptor signaling pathway (GO:0001973)5.49206039
15regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38796316
16striatum development (GO:0021756)5.35380916
17synaptic vesicle maturation (GO:0016188)5.32577068
18negative regulation of axon guidance (GO:1902668)5.29736628
19adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.20856552
20head development (GO:0060322)5.16538141
21regulation of long-term neuronal synaptic plasticity (GO:0048169)5.13258344
22response to amphetamine (GO:0001975)4.95975067
23vocalization behavior (GO:0071625)4.89997327
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88595644
25auditory behavior (GO:0031223)4.86980036
26positive regulation of synaptic transmission, GABAergic (GO:0032230)4.84671285
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73585896
28dopamine receptor signaling pathway (GO:0007212)4.72901008
29regulation of glutamate receptor signaling pathway (GO:1900449)4.68984253
30regulation of neuronal synaptic plasticity (GO:0048168)4.66191338
31behavioral response to cocaine (GO:0048148)4.63823041
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.62225099
33positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.59504250
34nucleobase catabolic process (GO:0046113)4.59154847
35negative regulation of cytosolic calcium ion concentration (GO:0051481)4.57271575
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.55735935
37regulation of action potential (GO:0098900)4.51950253
38neurotransmitter-gated ion channel clustering (GO:0072578)4.49295719
39positive regulation of neurotransmitter transport (GO:0051590)4.48631067
40regulation of glutamate secretion (GO:0014048)4.44345751
41regulation of dendritic spine morphogenesis (GO:0061001)4.44186020
42regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.36089332
43regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.36089332
44detection of calcium ion (GO:0005513)4.32802202
45activated T cell proliferation (GO:0050798)4.31122700
46regulation of female receptivity (GO:0045924)4.28398995
47cAMP catabolic process (GO:0006198)4.27975704
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.27469931
49synaptic vesicle exocytosis (GO:0016079)4.24937779
50activation of MAPKKK activity (GO:0000185)4.18406980
51synapse assembly (GO:0007416)4.16394709
52ionotropic glutamate receptor signaling pathway (GO:0035235)4.14632889
53neuromuscular process controlling balance (GO:0050885)4.14443289
54response to auditory stimulus (GO:0010996)4.14322315
55substrate-independent telencephalic tangential migration (GO:0021826)4.13979980
56substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.13979980
57neurotransmitter secretion (GO:0007269)4.13281333
58protein localization to synapse (GO:0035418)4.11877553
59neuron-neuron synaptic transmission (GO:0007270)4.11675635
60dendritic spine morphogenesis (GO:0060997)4.10376475
61regulation of synaptic vesicle exocytosis (GO:2000300)4.07365007
62exploration behavior (GO:0035640)4.07347292
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.03305394
64regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03055489
65synaptic vesicle docking involved in exocytosis (GO:0016081)4.02511069
66positive regulation of neurotransmitter secretion (GO:0001956)4.00520054
67axonal fasciculation (GO:0007413)3.99379903
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90551494
69calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.90072257
70regulation of cilium movement (GO:0003352)3.89515684
71long-term memory (GO:0007616)3.89050808
72phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.88279387
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.88057833
74regulation of neurotransmitter uptake (GO:0051580)3.86532761
75synaptic transmission, cholinergic (GO:0007271)3.85248860
76synaptic transmission, glutamatergic (GO:0035249)3.81625883
77transmission of nerve impulse (GO:0019226)3.81062686
78positive regulation of membrane potential (GO:0045838)3.80683826
79neuronal ion channel clustering (GO:0045161)3.80163239
80female mating behavior (GO:0060180)3.78319793
81cyclic nucleotide catabolic process (GO:0009214)3.76323417
82layer formation in cerebral cortex (GO:0021819)3.73311706
83gamma-aminobutyric acid transport (GO:0015812)3.71752976
84behavioral fear response (GO:0001662)3.70702031
85behavioral defense response (GO:0002209)3.70702031
86regulation of postsynaptic membrane potential (GO:0060078)3.69818185
87visual learning (GO:0008542)3.67391348
88regulation of protein kinase A signaling (GO:0010738)3.67044289
89adult walking behavior (GO:0007628)3.64067049
90regulation of synaptic plasticity (GO:0048167)3.63770885
91neuronal action potential propagation (GO:0019227)3.63520527
92peristalsis (GO:0030432)3.62638805
93epithelial cell differentiation involved in kidney development (GO:0035850)3.61218114
94neuron recognition (GO:0008038)3.60499957
95neuromuscular process controlling posture (GO:0050884)3.59578380
96activation of protein kinase A activity (GO:0034199)3.59560571
97regulation of axon guidance (GO:1902667)3.59535457
98regulation of synaptic vesicle transport (GO:1902803)3.59403953
99response to histamine (GO:0034776)3.58707194
100mechanosensory behavior (GO:0007638)3.56576560
101negative regulation of dendrite development (GO:2000171)3.56085583
102regulation of dopamine secretion (GO:0014059)3.55612103
103regulation of norepinephrine secretion (GO:0014061)3.54884354
104cAMP metabolic process (GO:0046058)3.54651780
105glutamate receptor signaling pathway (GO:0007215)3.53944660
106neuron projection extension involved in neuron projection guidance (GO:1902284)3.52769171
107axon extension involved in axon guidance (GO:0048846)3.52769171
108membrane hyperpolarization (GO:0060081)3.50852792
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50004700
110neuronal action potential (GO:0019228)3.48362882
111regulation of synaptic transmission, GABAergic (GO:0032228)3.47470788
112response to amine (GO:0014075)3.46601628
113regulation of feeding behavior (GO:0060259)3.46210382
114mating behavior (GO:0007617)3.46017199
115visual behavior (GO:0007632)3.45806543
116regulation of voltage-gated calcium channel activity (GO:1901385)3.44818898
117negative regulation of amino acid transport (GO:0051956)3.44545884
118regulation of dendritic spine development (GO:0060998)3.43496813
119regulation of synapse maturation (GO:0090128)3.42694070
120long-term synaptic potentiation (GO:0060291)3.42420611
121membrane depolarization during action potential (GO:0086010)3.39033652
122organelle transport along microtubule (GO:0072384)3.38447943
123positive regulation of synapse maturation (GO:0090129)3.37731971
124platelet dense granule organization (GO:0060155)3.37608867
125fear response (GO:0042596)3.36580672
126regulation of microtubule-based movement (GO:0060632)3.36251738
127neuron cell-cell adhesion (GO:0007158)3.34507160
128glutamate secretion (GO:0014047)3.33818105
129positive regulation of mitochondrial fission (GO:0090141)3.29855492
130glycine transport (GO:0015816)3.28730141
131postsynaptic membrane organization (GO:0001941)3.28474843
132learning (GO:0007612)3.27214548
133vesicle transport along microtubule (GO:0047496)3.26657935
134drinking behavior (GO:0042756)3.22970681
135regulation of neurotransmitter levels (GO:0001505)3.20682407
136negative regulation of amine transport (GO:0051953)3.19802416
137axoneme assembly (GO:0035082)3.19049006
138cAMP biosynthetic process (GO:0006171)3.17098375
139neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16928894
140regulation of synaptic transmission, dopaminergic (GO:0032225)3.16653355
141positive regulation of oligodendrocyte differentiation (GO:0048714)3.14832629
142protein polyglutamylation (GO:0018095)3.13858342
143synapse organization (GO:0050808)3.12894652
144negative regulation of JUN kinase activity (GO:0043508)3.11528868
145ganglion development (GO:0061548)3.05434598
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04437922
147cerebellar Purkinje cell differentiation (GO:0021702)2.98833735
148neurofilament cytoskeleton organization (GO:0060052)2.98599390
149calcium ion-dependent exocytosis (GO:0017156)2.98585100
150negative regulation of axon extension involved in axon guidance (GO:0048843)2.98494151
151positive regulation of gastrulation (GO:2000543)2.96353198
152negative regulation of receptor-mediated endocytosis (GO:0048261)2.95840179
153cytoskeleton-dependent intracellular transport (GO:0030705)2.95651932
154piRNA metabolic process (GO:0034587)2.95508230
155inner ear receptor cell differentiation (GO:0060113)2.94695907
156cell-cell junction maintenance (GO:0045217)2.88900366
157cell junction maintenance (GO:0034331)2.84829806
158neuromuscular synaptic transmission (GO:0007274)2.83022233
159mitochondrion localization (GO:0051646)2.82211422
160N-glycan processing (GO:0006491)2.79846246
161retinal ganglion cell axon guidance (GO:0031290)2.78266085
162glycosphingolipid biosynthetic process (GO:0006688)2.74759179
163axon cargo transport (GO:0008088)2.73214844
164microtubule-based transport (GO:0010970)2.71583738
165entrainment of circadian clock (GO:0009649)2.70397678
166protein localization to cilium (GO:0061512)2.70018473
167kynurenine metabolic process (GO:0070189)2.69552353
168protein targeting to lysosome (GO:0006622)2.68497115
169establishment of protein localization to vacuole (GO:0072666)2.68497115
170protein targeting to vacuole (GO:0006623)2.68497115
171membrane depolarization (GO:0051899)2.68155369
172action potential (GO:0001508)2.67848740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11975213
2* RARB_27405468_Chip-Seq_BRAIN_Mouse4.10954888
3VDR_22108803_ChIP-Seq_LS180_Human4.04828863
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28165310
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19798026
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.14593038
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10246641
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.01092411
9GBX2_23144817_ChIP-Seq_PC3_Human3.01088485
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83993760
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81605573
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81605573
13ZNF274_21170338_ChIP-Seq_K562_Hela2.80340725
14DROSHA_22980978_ChIP-Seq_HELA_Human2.79416678
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.75083737
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73575557
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.71226809
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70535867
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.67789932
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65988509
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.57875825
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52187737
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43937826
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42312160
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40143206
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37184115
27IGF1R_20145208_ChIP-Seq_DFB_Human2.33095689
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32204321
29* REST_18959480_ChIP-ChIP_MESCs_Mouse2.30252496
30* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28279127
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.24292149
32RNF2_27304074_Chip-Seq_NSC_Mouse2.22062820
33AR_21572438_ChIP-Seq_LNCaP_Human2.15427884
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00628660
35* EED_16625203_ChIP-ChIP_MESCs_Mouse1.95244969
36* ERG_21242973_ChIP-ChIP_JURKAT_Human1.87755440
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87304410
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85767020
39IRF1_19129219_ChIP-ChIP_H3396_Human1.83346087
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67819540
41* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56374857
42TAF15_26573619_Chip-Seq_HEK293_Human1.52213219
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50741682
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46715585
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43295454
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40087586
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36725247
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35707843
49SMAD4_21799915_ChIP-Seq_A2780_Human1.34558205
50KDM2B_26808549_Chip-Seq_K562_Human1.34446038
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33984433
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.32243693
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31590308
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29307188
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29169481
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28293883
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.27546932
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26912142
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24528823
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24457109
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24277100
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.22916617
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22166735
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21305706
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19247837
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.18899115
67* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18656248
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.17949704
69AR_19668381_ChIP-Seq_PC3_Human1.17933076
70* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15092172
71ER_23166858_ChIP-Seq_MCF-7_Human1.13717035
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13023450
73* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12587195
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11400816
75STAT3_23295773_ChIP-Seq_U87_Human1.09227648
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09199225
77* CTCF_27219007_Chip-Seq_Bcells_Human1.08164045
78JUN_21703547_ChIP-Seq_K562_Human1.07612807
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.04885970
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03692274
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03588714
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03260978
83FUS_26573619_Chip-Seq_HEK293_Human1.03122845
84* SMAD3_21741376_ChIP-Seq_HESCs_Human1.03062425
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02083858
86P300_19829295_ChIP-Seq_ESCs_Human0.99964978
87ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99073189
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98983149
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98784705
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97565304
91EWS_26573619_Chip-Seq_HEK293_Human0.97052132
92KLF4_19829295_ChIP-Seq_ESCs_Human0.96789222
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96417154
94REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95904121
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95805067
96OCT4_20526341_ChIP-Seq_ESCs_Human0.94440637
97TCF4_23295773_ChIP-Seq_U87_Human0.94063157
98AR_25329375_ChIP-Seq_VCAP_Human0.93660077
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.93558331
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93377434
101NCOR_22424771_ChIP-Seq_293T_Human0.92998452
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92883427
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92596491
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92472995
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92132475
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91988694
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91975269
108AHR_22903824_ChIP-Seq_MCF-7_Human0.91652129
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.91231754
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90367240
111* FLI1_21867929_ChIP-Seq_TH2_Mouse0.90092571
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89954693
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.89359536
114RUNX2_22187159_ChIP-Seq_PCA_Human0.89206636
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88911165
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88451796
117* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88214657
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88213198
119* TAF2_19829295_ChIP-Seq_ESCs_Human0.87349768
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.86942256
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.86847709
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.85962548
123* SMAD3_21741376_ChIP-Seq_ESCs_Human0.85778235
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84842662
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84807505
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84507500
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.83084223
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82879277
129* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82622361
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82252956
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82216579
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.81879516
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.80630586
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.80339570
135* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79507359
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79409302
137TP53_16413492_ChIP-PET_HCT116_Human0.78623271
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78480608
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78418398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy9.16446225
2MP0004859_abnormal_synaptic_plasticity6.12764011
3MP0003880_abnormal_central_pattern4.14399352
4MP0003635_abnormal_synaptic_transmissio4.07140672
5MP0009745_abnormal_behavioral_response3.78998409
6MP0002102_abnormal_ear_morphology3.60644593
7MP0003121_genomic_imprinting3.54075147
8* MP0002063_abnormal_learning/memory/cond3.42390650
9MP0004270_analgesia3.20686108
10MP0008877_abnormal_DNA_methylation3.18356776
11MP0001529_abnormal_vocalization3.04873571
12MP0002064_seizures2.98776016
13MP0002572_abnormal_emotion/affect_behav2.82612880
14MP0003011_delayed_dark_adaptation2.73427995
15MP0009046_muscle_twitch2.70635746
16MP0001486_abnormal_startle_reflex2.70378243
17MP0001968_abnormal_touch/_nociception2.56308694
18MP0005423_abnormal_somatic_nervous2.51133289
19MP0002272_abnormal_nervous_system2.42772129
20MP0002909_abnormal_adrenal_gland2.41475152
21MP0006072_abnormal_retinal_apoptosis2.23431626
22MP0005646_abnormal_pituitary_gland2.14602877
23MP0003890_abnormal_embryonic-extraembry2.11644544
24MP0002734_abnormal_mechanical_nocicepti2.11098567
25MP0001501_abnormal_sleep_pattern2.03964993
26MP0004924_abnormal_behavior2.01685884
27MP0005386_behavior/neurological_phenoty2.01685884
28MP0005409_darkened_coat_color1.97008691
29MP0001970_abnormal_pain_threshold1.84193324
30MP0002733_abnormal_thermal_nociception1.80433880
31MP0001188_hyperpigmentation1.77544958
32MP0003878_abnormal_ear_physiology1.76509794
33MP0005377_hearing/vestibular/ear_phenot1.76509794
34MP0002736_abnormal_nociception_after1.70400895
35MP0002557_abnormal_social/conspecific_i1.70320068
36MP0001984_abnormal_olfaction1.69610652
37MP0001440_abnormal_grooming_behavior1.65003654
38MP0004811_abnormal_neuron_physiology1.62479181
39MP0008569_lethality_at_weaning1.57581637
40MP0003123_paternal_imprinting1.56672938
41MP0005253_abnormal_eye_physiology1.52059443
42MP0002332_abnormal_exercise_endurance1.51894523
43MP0009780_abnormal_chondrocyte_physiolo1.48599184
44MP0001986_abnormal_taste_sensitivity1.48246317
45MP0001905_abnormal_dopamine_level1.46278039
46MP0002067_abnormal_sensory_capabilities1.45886646
47MP0003075_altered_response_to1.41189679
48MP0008872_abnormal_physiological_respon1.37088033
49MP0008874_decreased_physiological_sensi1.35778503
50MP0005167_abnormal_blood-brain_barrier1.31359685
51MP0003329_amyloid_beta_deposits1.31168239
52MP0005083_abnormal_biliary_tract1.31013512
53MP0003879_abnormal_hair_cell1.30991664
54MP0003633_abnormal_nervous_system1.29131601
55MP0002066_abnormal_motor_capabilities/c1.27966609
56MP0002735_abnormal_chemical_nociception1.27717728
57MP0000013_abnormal_adipose_tissue1.27535386
58MP0004885_abnormal_endolymph1.23388082
59MP0001177_atelectasis1.22825837
60MP0002184_abnormal_innervation1.22784382
61MP0000955_abnormal_spinal_cord1.19590295
62MP0010234_abnormal_vibrissa_follicle1.10868527
63MP0002882_abnormal_neuron_morphology1.08417113
64MP0000778_abnormal_nervous_system1.06649435
65MP0003283_abnormal_digestive_organ1.03825908
66MP0008961_abnormal_basal_metabolism1.02255493
67MP0004085_abnormal_heartbeat1.01899126
68MP0003631_nervous_system_phenotype1.00159277
69MP0001502_abnormal_circadian_rhythm0.98838300
70MP0004142_abnormal_muscle_tone0.97950899
71MP0002069_abnormal_eating/drinking_beha0.97055554
72MP0002090_abnormal_vision0.96167941
73MP0004858_abnormal_nervous_system0.94427233
74MP0003690_abnormal_glial_cell0.93560433
75MP0005535_abnormal_body_temperature0.92873614
76MP0004264_abnormal_extraembryonic_tissu0.91241977
77MP0004133_heterotaxia0.89482093
78MP0008789_abnormal_olfactory_epithelium0.88127765
79MP0000751_myopathy0.87996002
80MP0002876_abnormal_thyroid_physiology0.85751931
81MP0003787_abnormal_imprinting0.84252866
82* MP0002152_abnormal_brain_morphology0.83752294
83MP0001764_abnormal_homeostasis0.82713976
84MP0000920_abnormal_myelination0.80249886
85MP0005195_abnormal_posterior_eye0.80235364
86MP0005623_abnormal_meninges_morphology0.80200817
87MP0003861_abnormal_nervous_system0.79529439
88MP0005645_abnormal_hypothalamus_physiol0.78574942
89MP0006276_abnormal_autonomic_nervous0.77499959
90MP0005499_abnormal_olfactory_system0.75761458
91MP0005394_taste/olfaction_phenotype0.75761458
92MP0002160_abnormal_reproductive_system0.73288472
93MP0002229_neurodegeneration0.71379902
94MP0004130_abnormal_muscle_cell0.70904530
95MP0003137_abnormal_impulse_conducting0.69864209
96MP0000631_abnormal_neuroendocrine_gland0.68841330
97MP0005391_vision/eye_phenotype0.67803787
98MP0003122_maternal_imprinting0.66775111
99MP0003634_abnormal_glial_cell0.64183658
100MP0002928_abnormal_bile_duct0.62678707
101MP0005166_decreased_susceptibility_to0.60567030
102MP0002254_reproductive_system_inflammat0.59422926
103MP0003195_calcinosis0.59399757
104MP0001664_abnormal_digestion0.59226173
105MP0000604_amyloidosis0.58515031
106MP0000026_abnormal_inner_ear0.57586314
107MP0008995_early_reproductive_senescence0.56789974
108MP0000569_abnormal_digit_pigmentation0.55415989
109MP0003938_abnormal_ear_development0.55320402
110MP0005389_reproductive_system_phenotype0.55136404
111MP0003632_abnormal_nervous_system0.53439494
112MP0005551_abnormal_eye_electrophysiolog0.52233100
113MP0001293_anophthalmia0.51535641
114MP0000538_abnormal_urinary_bladder0.50573178
115MP0002638_abnormal_pupillary_reflex0.50526421
116MP0004043_abnormal_pH_regulation0.50099079
117MP0001943_abnormal_respiration0.47636797
118MP0004742_abnormal_vestibular_system0.47430431
119MP0003956_abnormal_body_size0.44834315
120MP0000003_abnormal_adipose_tissue0.42414091
121MP0002752_abnormal_somatic_nervous0.41715655
122MP0001963_abnormal_hearing_physiology0.40223277
123MP0000230_abnormal_systemic_arterial0.38769076
124MP0010386_abnormal_urinary_bladder0.37930675
125MP0001485_abnormal_pinna_reflex0.37618808
126MP0003303_peritoneal_inflammation0.37308716
127MP0010769_abnormal_survival0.36938728
128MP0004036_abnormal_muscle_relaxation0.36896812
129MP0005620_abnormal_muscle_contractility0.36453972
130MP0004145_abnormal_muscle_electrophysio0.35903092
131MP0002082_postnatal_lethality0.35766836
132MP0010770_preweaning_lethality0.35766836
133MP0004233_abnormal_muscle_weight0.34914254

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.67063885
2Focal motor seizures (HP:0011153)7.72701401
3Pendular nystagmus (HP:0012043)5.81967477
4Focal seizures (HP:0007359)5.66358700
5Polyphagia (HP:0002591)4.94599298
6Chronic hepatic failure (HP:0100626)4.78285519
7Annular pancreas (HP:0001734)4.77641849
8Resting tremor (HP:0002322)4.76125141
9Torticollis (HP:0000473)4.55495804
10Visual hallucinations (HP:0002367)4.54892153
11Abnormality of the labia minora (HP:0012880)4.48786142
12Cortical dysplasia (HP:0002539)4.42976789
13Poor eye contact (HP:0000817)4.27092333
14Anxiety (HP:0000739)4.09231998
15Focal dystonia (HP:0004373)3.95269271
16Failure to thrive in infancy (HP:0001531)3.94036907
17Craniofacial dystonia (HP:0012179)3.89019932
18Action tremor (HP:0002345)3.86593123
19Abnormal social behavior (HP:0012433)3.83010251
20Impaired social interactions (HP:0000735)3.83010251
21Ankle clonus (HP:0011448)3.77038688
22Depression (HP:0000716)3.74142937
23Abnormal pancreas size (HP:0012094)3.72584891
24Impaired vibration sensation in the lower limbs (HP:0002166)3.68168900
25Esotropia (HP:0000565)3.62035473
26Broad-based gait (HP:0002136)3.60720722
27Epileptic encephalopathy (HP:0200134)3.56001562
28Generalized tonic-clonic seizures (HP:0002069)3.51127327
29Buphthalmos (HP:0000557)3.50289166
30Ankyloglossia (HP:0010296)3.46833369
31Febrile seizures (HP:0002373)3.40636378
32Dysdiadochokinesis (HP:0002075)3.38137201
33Absence seizures (HP:0002121)3.34066098
34Abnormal hair whorl (HP:0010721)3.30008719
35Urinary bladder sphincter dysfunction (HP:0002839)3.19565042
36Stereotypic behavior (HP:0000733)3.17301056
37Oligomenorrhea (HP:0000876)3.15074519
38Abnormality of midbrain morphology (HP:0002418)3.14233364
39Molar tooth sign on MRI (HP:0002419)3.14233364
40Dialeptic seizures (HP:0011146)3.11002622
41Pointed chin (HP:0000307)3.09178468
42Papilledema (HP:0001085)3.05800486
43Lower limb amyotrophy (HP:0007210)3.04141423
44Hemorrhage of the eye (HP:0011885)3.03964674
45Gaze-evoked nystagmus (HP:0000640)3.03781699
46Scanning speech (HP:0002168)3.02736969
47Hypoplasia of the brainstem (HP:0002365)3.01660012
48Aplasia/Hypoplasia of the brainstem (HP:0007362)3.01660012
49Limb dystonia (HP:0002451)3.01041629
50Spastic tetraplegia (HP:0002510)2.98664278
51Sleep apnea (HP:0010535)2.98025161
52Abnormal eating behavior (HP:0100738)2.96428881
53Prolonged QT interval (HP:0001657)2.95891968
54Urinary urgency (HP:0000012)2.94475729
55Abnormality of the corticospinal tract (HP:0002492)2.94315474
56Dysmetria (HP:0001310)2.94090743
57Abnormal respiratory motile cilium morphology (HP:0005938)2.93358033
58Abnormal respiratory epithelium morphology (HP:0012253)2.93358033
59Atonic seizures (HP:0010819)2.92582579
60Postural instability (HP:0002172)2.91141102
61Agitation (HP:0000713)2.80579178
62Truncal ataxia (HP:0002078)2.79824452
63Dysmetric saccades (HP:0000641)2.76238681
64Supranuclear gaze palsy (HP:0000605)2.75164363
65Polygenic inheritance (HP:0010982)2.74164134
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71574767
67Abnormal EKG (HP:0003115)2.70404383
68Progressive cerebellar ataxia (HP:0002073)2.70262927
69Megalencephaly (HP:0001355)2.69268933
70Retinal dysplasia (HP:0007973)2.65352119
71Atrioventricular block (HP:0001678)2.63040993
72Abnormality of oral frenula (HP:0000190)2.62013341
73Abolished electroretinogram (ERG) (HP:0000550)2.60949713
74Spastic gait (HP:0002064)2.59192979
75Amblyopia (HP:0000646)2.58429457
76Specific learning disability (HP:0001328)2.58071190
77Hypoalbuminemia (HP:0003073)2.56883088
78Abnormal albumin level (HP:0012116)2.56883088
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.55432474
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55432474
81Distal lower limb amyotrophy (HP:0008944)2.54876735
82Pachygyria (HP:0001302)2.53709006
83Intention tremor (HP:0002080)2.53140408
84Hip dysplasia (HP:0001385)2.52290538
85Impaired smooth pursuit (HP:0007772)2.51359003
86Mutism (HP:0002300)2.48706148
87Impaired vibratory sensation (HP:0002495)2.48644110
88Bradykinesia (HP:0002067)2.47546038
89True hermaphroditism (HP:0010459)2.43582921
903-Methylglutaconic aciduria (HP:0003535)2.40247558
91Limb hypertonia (HP:0002509)2.30831376
92Polymicrogyria (HP:0002126)2.29925418
93Hyperventilation (HP:0002883)2.27383525
94Truncus arteriosus (HP:0001660)2.27323380
95Progressive inability to walk (HP:0002505)2.26887606
96Tubulointerstitial fibrosis (HP:0005576)2.26653574
97Decreased muscle mass (HP:0003199)2.25306249
98Lissencephaly (HP:0001339)2.24975573
99Poor suck (HP:0002033)2.23852018
100Status epilepticus (HP:0002133)2.23027643
101Labial hypoplasia (HP:0000066)2.22670504
102Neurofibrillary tangles (HP:0002185)2.21255274
103Clonus (HP:0002169)2.21134991
104Cerebral inclusion bodies (HP:0100314)2.20964341
105Lower limb asymmetry (HP:0100559)2.20396597
106Abnormality of the lower motor neuron (HP:0002366)2.20164590
107Incomplete penetrance (HP:0003829)2.19074824
108Heart block (HP:0012722)2.18717230
109Pancreatic fibrosis (HP:0100732)2.14575810
110Ventricular fibrillation (HP:0001663)2.14239935
111Abnormality of the anterior chamber (HP:0000593)2.13972493
112Lower limb muscle weakness (HP:0007340)2.13945936
113Microretrognathia (HP:0000308)2.12841972
114Upper limb amyotrophy (HP:0009129)2.07903913
115Distal upper limb amyotrophy (HP:0007149)2.07903913
116Gait imbalance (HP:0002141)2.07123356
117Congenital glaucoma (HP:0001087)2.05557310
118Morphological abnormality of the pyramidal tract (HP:0002062)2.05469111
119Axonal loss (HP:0003447)2.05365628
120Termporal pattern (HP:0011008)2.05040251
121Insidious onset (HP:0003587)2.05040251
122Bowel incontinence (HP:0002607)2.04978488
123Abnormality of ocular smooth pursuit (HP:0000617)2.04703478
124Hemiparesis (HP:0001269)2.03666514
125Pancreatic cysts (HP:0001737)2.01254700
126Cortical visual impairment (HP:0100704)2.01004653
127Neuronal loss in central nervous system (HP:0002529)2.00940570
128Hypoplastic female external genitalia (HP:0012815)1.99342796
129Obstructive sleep apnea (HP:0002870)1.98541320
130Abnormal atrioventricular conduction (HP:0005150)1.97418252
131Hypomagnesemia (HP:0002917)1.97091044
132Hypogonadotrophic hypogonadism (HP:0000044)1.96305995
133Hemiplegia (HP:0002301)1.95053729
134Epileptiform EEG discharges (HP:0011182)1.93411286
135Drooling (HP:0002307)1.93261586
136Excessive salivation (HP:0003781)1.93261586
137Abnormal ciliary motility (HP:0012262)1.92934728
138Palpebral edema (HP:0100540)1.92524935
139Insomnia (HP:0100785)1.92300569
140EEG with generalized epileptiform discharges (HP:0011198)1.90917532
141Long foot (HP:0001833)1.89874440
142Hypsarrhythmia (HP:0002521)1.88853194
143Vaginal atresia (HP:0000148)1.88501933
144Spinal canal stenosis (HP:0003416)1.86590868
145Abnormality of saccadic eye movements (HP:0000570)1.85250464
146Abnormal large intestine physiology (HP:0012700)1.84135930
147Rigidity (HP:0002063)1.83404783
148Neoplasm of the peripheral nervous system (HP:0100007)1.82813006
149Abnormality of the labia (HP:0000058)1.82570399
150Generalized hypopigmentation (HP:0007513)1.82064643
151Abnormality of the periventricular white matter (HP:0002518)1.81711873
152Onion bulb formation (HP:0003383)1.81446749
153Genital tract atresia (HP:0001827)1.81218488
154Fetal akinesia sequence (HP:0001989)1.80663217
155Restlessness (HP:0000711)1.80058759
156Dysphonia (HP:0001618)1.79551462
157Pheochromocytoma (HP:0002666)1.77765050
158Generalized hypotonia (HP:0001290)1.77718436
159Abnormal tarsal ossification (HP:0008369)1.77150309
160Hypoplasia of the corpus callosum (HP:0002079)1.75224290
161Bilateral microphthalmos (HP:0007633)1.74471382
162Narrow forehead (HP:0000341)1.74129685
163Wrist flexion contracture (HP:0001239)1.73764849
164Growth hormone deficiency (HP:0000824)1.72373420
165Hypoventilation (HP:0002791)1.71316600
166Aplasia/Hypoplasia of the sternum (HP:0006714)1.71285597
167Narrow nasal bridge (HP:0000446)1.70398256
168Protruding tongue (HP:0010808)1.69658965
169Tubulointerstitial abnormality (HP:0001969)1.69419676
170Postaxial foot polydactyly (HP:0001830)1.69372752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA48.11455238
2EPHA34.76557438
3NTRK33.97370185
4MAP3K93.62650421
5SIK33.02281794
6KSR22.93341572
7WNK32.88648563
8DAPK22.87820573
9RIPK42.51017075
10PRKD32.47423870
11EPHB12.40780514
12CAMKK12.24729115
13MAP3K112.20944346
14MINK12.16341032
15NTRK12.13604490
16ARAF2.09284231
17MAP3K132.02163642
18FES1.96475162
19NTRK21.93851668
20BCR1.93129412
21DYRK21.90719825
22MARK11.89625099
23MAP3K41.86392869
24KSR11.84105429
25EIF2AK31.70157862
26TAOK11.69329419
27CDK51.62278199
28FRK1.58173946
29PAK61.57394216
30STK161.57194271
31DAPK11.56374146
32MAP3K21.55772023
33CAMKK21.53852838
34WNK41.53498917
35TNIK1.47239179
36TYRO31.44006850
37SIK21.43931305
38NEK21.42065064
39MAP2K71.35905024
40RAF11.28574246
41DYRK31.25568164
42MAP3K51.19160254
43NUAK11.14187695
44STK391.13544232
45MAP2K41.08534567
46MAP4K21.04773256
47PRPF4B1.03411878
48SGK4940.98163444
49SGK2230.98163444
50PRKCH0.96404479
51BMPR20.96364735
52UHMK10.95630409
53PRKCQ0.93009185
54CDK180.91433885
55CDK150.90492402
56PINK10.89696001
57TRIM280.88453402
58CDK140.87576136
59STK380.86582550
60FER0.84688500
61PRKCG0.84587000
62GRK50.83921421
63MARK20.82654651
64CAMK2B0.82057991
65MARK30.81352678
66RET0.80913934
67STK110.80693960
68SGK10.80474015
69CSNK1G30.80401832
70SGK20.79829885
71PDPK10.79422167
72NEK10.79387527
73CDK11A0.79143701
74MAPK130.78941646
75CAMK2A0.78509147
76SIK10.77669885
77RPS6KA40.76257344
78MAP3K10.75839307
79ALK0.75719147
80OXSR10.74991841
81SGK30.74537110
82CAMK1D0.73343914
83PDK10.72956443
84TNK20.68322282
85PTK2B0.68030980
86CAMK10.67867331
87PIK3CA0.66236832
88MAP3K120.64289467
89LIMK10.63916208
90MAP2K10.62335997
91CSNK1A1L0.61125701
92PLK20.60339733
93CSNK1G10.59834886
94DAPK30.58841233
95NEK60.57398976
96GRK10.56938457
97MOS0.55288790
98FYN0.54623802
99IRAK10.53967968
100PRKCZ0.53541291
101RPS6KA50.53270894
102LMTK20.53072252
103RPS6KA30.52793922
104BRSK10.50493450
105RIPK10.50154477
106PRKD20.48640764
107PHKG10.45891454
108PHKG20.45891454
109CAMK40.44446845
110MAPK100.44196667
111BRAF0.43885412
112FGFR40.42737063
113TRIB30.40974710
114DMPK0.40125327
115FGFR20.39754741
116SCYL20.39256870
117CAMK2G0.38951185
118CDK190.38655439
119CAMK2D0.38403548
120RPS6KB10.37858767
121INSRR0.37743568
122PRKCE0.35850415
123CSNK1G20.34802206
124CASK0.34752260
125FGR0.33372401
126PRKCB0.33347742
127DYRK1A0.32282323
128TLK10.32146009
129IKBKE0.31672868
130PRKAA10.31566315
131RPS6KA20.31421493
132PAK30.31175460
133PNCK0.30900398
134PRKACA0.30794192
135PRKACG0.30724659
136DYRK1B0.28521300
137MAP3K60.28520009
138CSNK1A10.27578383
139WNK10.27199576
140MAPK80.25975257
141PRKCA0.25664088
142PKN10.24848398
143TIE10.24602453
144MAPK150.24133355

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.83879637
2Morphine addiction_Homo sapiens_hsa050323.01202972
3Nicotine addiction_Homo sapiens_hsa050332.96531264
4Cocaine addiction_Homo sapiens_hsa050302.88171801
5Amphetamine addiction_Homo sapiens_hsa050312.85825094
6GABAergic synapse_Homo sapiens_hsa047272.84799516
7Circadian entrainment_Homo sapiens_hsa047132.75717872
8Synaptic vesicle cycle_Homo sapiens_hsa047212.71310823
9Long-term potentiation_Homo sapiens_hsa047202.63146311
10Dopaminergic synapse_Homo sapiens_hsa047282.49876834
11Glutamatergic synapse_Homo sapiens_hsa047242.47740617
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41773838
13Cholinergic synapse_Homo sapiens_hsa047252.28786410
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.06151052
15Renin secretion_Homo sapiens_hsa049242.05194522
16Salivary secretion_Homo sapiens_hsa049702.03071319
17Steroid biosynthesis_Homo sapiens_hsa001001.91917396
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85609906
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80327989
20Oxytocin signaling pathway_Homo sapiens_hsa049211.77033586
21Gastric acid secretion_Homo sapiens_hsa049711.74243286
22Insulin secretion_Homo sapiens_hsa049111.70478819
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69016416
24Calcium signaling pathway_Homo sapiens_hsa040201.67609829
25Gap junction_Homo sapiens_hsa045401.65546709
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.64787253
27Serotonergic synapse_Homo sapiens_hsa047261.64011489
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61887004
29Nitrogen metabolism_Homo sapiens_hsa009101.58303694
30Long-term depression_Homo sapiens_hsa047301.55553227
31Taste transduction_Homo sapiens_hsa047421.53948669
32GnRH signaling pathway_Homo sapiens_hsa049121.44125154
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40565663
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38510739
35cAMP signaling pathway_Homo sapiens_hsa040241.37597892
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32389360
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29763996
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26087940
39Glioma_Homo sapiens_hsa052141.16854587
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12808515
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11679118
42Ether lipid metabolism_Homo sapiens_hsa005651.08533532
43Huntingtons disease_Homo sapiens_hsa050161.07765917
44ABC transporters_Homo sapiens_hsa020101.07451824
45Phenylalanine metabolism_Homo sapiens_hsa003601.06721550
46Estrogen signaling pathway_Homo sapiens_hsa049151.06698302
47Oxidative phosphorylation_Homo sapiens_hsa001901.05491816
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02992642
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.02901923
50Alcoholism_Homo sapiens_hsa050341.00963273
51Fatty acid metabolism_Homo sapiens_hsa012120.99289988
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99064570
53Type II diabetes mellitus_Homo sapiens_hsa049300.98344966
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97447025
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96979397
56Fat digestion and absorption_Homo sapiens_hsa049750.95511361
57Melanogenesis_Homo sapiens_hsa049160.94595199
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93610133
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92834928
60Collecting duct acid secretion_Homo sapiens_hsa049660.92716052
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.90977792
62Linoleic acid metabolism_Homo sapiens_hsa005910.89483014
63Non-small cell lung cancer_Homo sapiens_hsa052230.87845563
64Phototransduction_Homo sapiens_hsa047440.87593602
65Oocyte meiosis_Homo sapiens_hsa041140.87209419
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85993809
67ErbB signaling pathway_Homo sapiens_hsa040120.85502481
68Cardiac muscle contraction_Homo sapiens_hsa042600.84965406
69Fatty acid elongation_Homo sapiens_hsa000620.84668125
70Regulation of autophagy_Homo sapiens_hsa041400.83498466
71Axon guidance_Homo sapiens_hsa043600.82170248
72Type I diabetes mellitus_Homo sapiens_hsa049400.81685367
73Alzheimers disease_Homo sapiens_hsa050100.81003191
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80917510
75Arginine and proline metabolism_Homo sapiens_hsa003300.79870757
76Dorso-ventral axis formation_Homo sapiens_hsa043200.79231636
77Dilated cardiomyopathy_Homo sapiens_hsa054140.77207965
78Rap1 signaling pathway_Homo sapiens_hsa040150.73404905
79Pancreatic secretion_Homo sapiens_hsa049720.71579704
80Thyroid hormone synthesis_Homo sapiens_hsa049180.71475451
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69931706
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69795615
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67675683
84Selenocompound metabolism_Homo sapiens_hsa004500.66029723
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.65386870
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65361838
87VEGF signaling pathway_Homo sapiens_hsa043700.64143132
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.63341888
89MAPK signaling pathway_Homo sapiens_hsa040100.63075497
90Choline metabolism in cancer_Homo sapiens_hsa052310.61544126
91Chemokine signaling pathway_Homo sapiens_hsa040620.57644941
92Prion diseases_Homo sapiens_hsa050200.55934561
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55620059
94Bile secretion_Homo sapiens_hsa049760.55391789
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55325729
96Vibrio cholerae infection_Homo sapiens_hsa051100.53378162
97mTOR signaling pathway_Homo sapiens_hsa041500.52835330
98Ras signaling pathway_Homo sapiens_hsa040140.51387809
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.51141292
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50855596
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48850430
102Butanoate metabolism_Homo sapiens_hsa006500.48837847
103Retinol metabolism_Homo sapiens_hsa008300.48809222
104Phagosome_Homo sapiens_hsa041450.48432619
105Histidine metabolism_Homo sapiens_hsa003400.48147332
106Glucagon signaling pathway_Homo sapiens_hsa049220.46071174
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45756683
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45677580
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44684155
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43896083
111Endometrial cancer_Homo sapiens_hsa052130.43631061
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42826226
113Thyroid cancer_Homo sapiens_hsa052160.42513622
114Endocytosis_Homo sapiens_hsa041440.41395547
115Platelet activation_Homo sapiens_hsa046110.41365220
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40869782
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40793803
118Fatty acid biosynthesis_Homo sapiens_hsa000610.39415042
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38949164
120African trypanosomiasis_Homo sapiens_hsa051430.38679977
121Tyrosine metabolism_Homo sapiens_hsa003500.38144767
122Ovarian steroidogenesis_Homo sapiens_hsa049130.37321181
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.36802378
124Renal cell carcinoma_Homo sapiens_hsa052110.36566279
125PPAR signaling pathway_Homo sapiens_hsa033200.34977402
126Circadian rhythm_Homo sapiens_hsa047100.34762299
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34428608
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33296266
129Insulin signaling pathway_Homo sapiens_hsa049100.32869332
130Parkinsons disease_Homo sapiens_hsa050120.32277899
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31377022
132Salmonella infection_Homo sapiens_hsa051320.30949876
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30947807
134Tight junction_Homo sapiens_hsa045300.29912506
135Arginine biosynthesis_Homo sapiens_hsa002200.29454614
136Inositol phosphate metabolism_Homo sapiens_hsa005620.27567996
137Tryptophan metabolism_Homo sapiens_hsa003800.27556093
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26506468
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.25036190
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24559845

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