GPR61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53179228
2synaptic vesicle exocytosis (GO:0016079)5.27005324
3vocalization behavior (GO:0071625)5.20333878
4neuron cell-cell adhesion (GO:0007158)4.98642404
5synaptic vesicle maturation (GO:0016188)4.95252059
6glutamate secretion (GO:0014047)4.95103469
7neuronal action potential propagation (GO:0019227)4.84042982
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80724938
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79594979
10locomotory exploration behavior (GO:0035641)4.71915741
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.68820260
12protein localization to synapse (GO:0035418)4.58512786
13regulation of synaptic vesicle exocytosis (GO:2000300)4.54087268
14regulation of glutamate receptor signaling pathway (GO:1900449)4.51109271
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.50152352
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.44701409
17serotonin metabolic process (GO:0042428)4.38766227
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31487760
19glutamate receptor signaling pathway (GO:0007215)4.24031542
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.21254149
21neuron-neuron synaptic transmission (GO:0007270)4.12948682
22exploration behavior (GO:0035640)4.00219026
23synaptic transmission, glutamatergic (GO:0035249)3.99690611
24regulation of synaptic vesicle transport (GO:1902803)3.98758436
25neurotransmitter secretion (GO:0007269)3.98502210
26primary amino compound metabolic process (GO:1901160)3.97543618
27regulation of neuronal synaptic plasticity (GO:0048168)3.96092547
28neuron recognition (GO:0008038)3.93455983
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.90527620
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85967240
31sodium ion export (GO:0071436)3.74601755
32neurotransmitter-gated ion channel clustering (GO:0072578)3.69712772
33regulation of dopamine secretion (GO:0014059)3.69144956
34long-term memory (GO:0007616)3.66521072
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64864092
36presynaptic membrane assembly (GO:0097105)3.64502630
37presynaptic membrane organization (GO:0097090)3.58532902
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57693152
39long-term synaptic potentiation (GO:0060291)3.54791661
40regulation of postsynaptic membrane potential (GO:0060078)3.54486341
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53294054
42gamma-aminobutyric acid transport (GO:0015812)3.52301626
43dendritic spine morphogenesis (GO:0060997)3.49977580
44cellular potassium ion homeostasis (GO:0030007)3.48907424
45mating behavior (GO:0007617)3.45850966
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.44860050
47neuromuscular synaptic transmission (GO:0007274)3.44197565
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.43845792
49transmission of nerve impulse (GO:0019226)3.43738198
50neurotransmitter transport (GO:0006836)3.43554833
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42451095
52axonal fasciculation (GO:0007413)3.42098843
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41750096
54regulation of synapse structural plasticity (GO:0051823)3.39195567
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37510396
56positive regulation of synapse maturation (GO:0090129)3.35757365
57positive regulation of dendritic spine morphogenesis (GO:0061003)3.35298575
58layer formation in cerebral cortex (GO:0021819)3.34506698
59positive regulation of membrane potential (GO:0045838)3.34274545
60regulation of synaptic plasticity (GO:0048167)3.33426195
61synaptic vesicle endocytosis (GO:0048488)3.33198326
62regulation of dendritic spine morphogenesis (GO:0061001)3.28992958
63response to histamine (GO:0034776)3.28863491
64behavioral response to cocaine (GO:0048148)3.25407162
65phosphorelay signal transduction system (GO:0000160)3.25077192
66regulation of vesicle fusion (GO:0031338)3.24910784
67neuronal action potential (GO:0019228)3.24061076
68neuromuscular process controlling posture (GO:0050884)3.22778223
69regulation of neurotransmitter secretion (GO:0046928)3.20421601
70proline transport (GO:0015824)3.19924375
71regulation of neurotransmitter levels (GO:0001505)3.17539368
72behavioral defense response (GO:0002209)3.16099766
73behavioral fear response (GO:0001662)3.16099766
74postsynaptic membrane organization (GO:0001941)3.14120569
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12152226
76adult walking behavior (GO:0007628)3.11674881
77membrane depolarization (GO:0051899)3.11293498
78regulation of cell communication by electrical coupling (GO:0010649)3.09719732
79negative regulation of dendrite morphogenesis (GO:0050774)3.08524474
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06968976
81learning (GO:0007612)3.04560969
82potassium ion import (GO:0010107)3.03854647
83regulation of synaptic transmission, GABAergic (GO:0032228)3.02984363
84regulation of glutamate secretion (GO:0014048)3.02746902
85cell differentiation in hindbrain (GO:0021533)3.02684456
86regulation of feeding behavior (GO:0060259)3.01854922
87fear response (GO:0042596)3.01763781
88membrane depolarization during action potential (GO:0086010)3.01132626
89regulation of neurotransmitter transport (GO:0051588)3.00542605
90positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00137687
91cerebellar Purkinje cell differentiation (GO:0021702)2.99525207
92retinal cone cell development (GO:0046549)2.99419733
93positive regulation of synapse assembly (GO:0051965)2.97924027
94synaptic transmission, dopaminergic (GO:0001963)2.97914754
95regulation of dendritic spine development (GO:0060998)2.97775301
96membrane hyperpolarization (GO:0060081)2.97609311
97activation of protein kinase A activity (GO:0034199)2.96371757
98synaptic transmission (GO:0007268)2.95759244
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95129608
100calcium ion-dependent exocytosis (GO:0017156)2.94971619
101positive regulation of neurotransmitter transport (GO:0051590)2.94259748
102acidic amino acid transport (GO:0015800)2.94006191
103potassium ion transmembrane transport (GO:0071805)2.93670335
104cellular potassium ion transport (GO:0071804)2.93670335
105positive regulation of neurotransmitter secretion (GO:0001956)2.93338378
106synapse assembly (GO:0007416)2.93198325
107cerebellar granule cell differentiation (GO:0021707)2.93031994
108startle response (GO:0001964)2.92457758
109regulation of synaptic transmission (GO:0050804)2.89764920
110negative regulation of neurotransmitter transport (GO:0051589)2.89626325
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88761056
112regulation of voltage-gated calcium channel activity (GO:1901385)2.88629604
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88332579
114innervation (GO:0060384)2.87601608
115negative regulation of cAMP biosynthetic process (GO:0030818)2.87016371
116positive regulation of dendritic spine development (GO:0060999)2.86562290
117detection of calcium ion (GO:0005513)2.85370311
118positive regulation of synaptic transmission (GO:0050806)2.84950173
119energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.84384990
120ATP hydrolysis coupled proton transport (GO:0015991)2.84384990
121neuromuscular process controlling balance (GO:0050885)2.84211899
122L-amino acid import (GO:0043092)2.83242356
123neuronal ion channel clustering (GO:0045161)2.80282869
124regulation of protein kinase A signaling (GO:0010738)2.79986195
125axon ensheathment in central nervous system (GO:0032291)2.79877778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87683622
2GBX2_23144817_ChIP-Seq_PC3_Human4.02254947
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22474217
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14434325
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00940647
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00292908
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63048393
8TAF15_26573619_Chip-Seq_HEK293_Human2.59398896
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59109890
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59109890
11REST_21632747_ChIP-Seq_MESCs_Mouse2.54893167
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51528984
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49847167
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48251198
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44969920
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.44325379
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43942276
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.35039744
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.30185820
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19402791
21DROSHA_22980978_ChIP-Seq_HELA_Human2.15940585
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.14188304
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.07345072
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.06176421
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04578344
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02532546
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00399352
28AR_21572438_ChIP-Seq_LNCaP_Human1.98131996
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93431926
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91373554
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87417792
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85931029
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82676127
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.76286534
35SMAD4_21799915_ChIP-Seq_A2780_Human1.73816875
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73718884
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73393612
38P300_19829295_ChIP-Seq_ESCs_Human1.66184624
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66061212
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62862127
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60274244
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55860693
43* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53682277
44FUS_26573619_Chip-Seq_HEK293_Human1.49637263
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.48874763
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48436081
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45453512
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44993971
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43482815
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.43389524
51ZNF274_21170338_ChIP-Seq_K562_Hela1.42616470
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38568498
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37951791
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35458967
55VDR_22108803_ChIP-Seq_LS180_Human1.35162586
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33316748
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.31318864
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30935070
59AR_25329375_ChIP-Seq_VCAP_Human1.29688966
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.29095012
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.28530659
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.26794226
63STAT3_23295773_ChIP-Seq_U87_Human1.25273439
64IGF1R_20145208_ChIP-Seq_DFB_Human1.21843074
65RNF2_27304074_Chip-Seq_NSC_Mouse1.21178460
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19779673
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17831836
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15681189
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.15427470
70ER_23166858_ChIP-Seq_MCF-7_Human1.15377047
71TCF4_23295773_ChIP-Seq_U87_Human1.13694140
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12156344
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.11654180
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10340273
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09891073
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09219875
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08358356
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07976226
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.07775711
80RUNX2_22187159_ChIP-Seq_PCA_Human1.05188282
81JUN_21703547_ChIP-Seq_K562_Human1.03223193
82AR_19668381_ChIP-Seq_PC3_Human1.02664692
83* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02663281
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02283335
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01936711
86AHR_22903824_ChIP-Seq_MCF-7_Human1.01175858
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00674616
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99920780
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99696060
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.99257760
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.99084493
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98717031
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97334162
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.97208567
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96593437
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96533326
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96421809
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95867103
99DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95715818
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95056989
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94882429
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94517158
103RING1B_27294783_Chip-Seq_NPCs_Mouse0.93639141
104BP1_19119308_ChIP-ChIP_Hs578T_Human0.93161511
105TP53_16413492_ChIP-PET_HCT116_Human0.92851810
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92194663
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.91622957
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91071720
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91071720
110KDM2B_26808549_Chip-Seq_REH_Human0.90958062
111BCAT_22108803_ChIP-Seq_LS180_Human0.89505631
112TP53_18474530_ChIP-ChIP_U2OS_Human0.88669379
113OCT1_27270436_Chip-Seq_PROSTATE_Human0.86901012
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.86522013
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.83528009
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.82252632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75129089
2MP0003880_abnormal_central_pattern5.35047111
3MP0003635_abnormal_synaptic_transmissio3.96205425
4MP0004270_analgesia3.51701992
5MP0009745_abnormal_behavioral_response3.43684246
6MP0002822_catalepsy3.36541626
7MP0002064_seizures3.29344728
8MP0002063_abnormal_learning/memory/cond3.19092930
9MP0009046_muscle_twitch3.14205146
10MP0001968_abnormal_touch/_nociception3.10732295
11MP0002572_abnormal_emotion/affect_behav2.84049110
12MP0002272_abnormal_nervous_system2.80048286
13MP0005423_abnormal_somatic_nervous2.57464871
14MP0002734_abnormal_mechanical_nocicepti2.56776302
15MP0002736_abnormal_nociception_after2.56421757
16MP0001486_abnormal_startle_reflex2.55808254
17MP0002735_abnormal_chemical_nociception2.50751498
18MP0001501_abnormal_sleep_pattern2.45561542
19MP0001440_abnormal_grooming_behavior2.29166404
20MP0001529_abnormal_vocalization2.16169979
21MP0003329_amyloid_beta_deposits2.08291053
22MP0002733_abnormal_thermal_nociception2.06557220
23MP0002067_abnormal_sensory_capabilities2.02350370
24MP0006276_abnormal_autonomic_nervous2.02018290
25MP0001970_abnormal_pain_threshold2.01952988
26MP0000778_abnormal_nervous_system1.85437047
27MP0001905_abnormal_dopamine_level1.84903316
28MP0004924_abnormal_behavior1.83734384
29MP0005386_behavior/neurological_phenoty1.83734384
30MP0002184_abnormal_innervation1.77231233
31MP0002557_abnormal_social/conspecific_i1.66219445
32MP0008569_lethality_at_weaning1.60457054
33MP0004142_abnormal_muscle_tone1.59209068
34MP0009780_abnormal_chondrocyte_physiolo1.57789919
35MP0004811_abnormal_neuron_physiology1.53463896
36MP0000955_abnormal_spinal_cord1.52789358
37MP0001984_abnormal_olfaction1.47943047
38MP0002882_abnormal_neuron_morphology1.43918701
39MP0002066_abnormal_motor_capabilities/c1.43215344
40MP0005646_abnormal_pituitary_gland1.42687728
41MP0003879_abnormal_hair_cell1.38749613
42MP0003122_maternal_imprinting1.37591844
43MP0000920_abnormal_myelination1.35312198
44MP0004885_abnormal_endolymph1.32089189
45MP0001986_abnormal_taste_sensitivity1.30987202
46MP0001502_abnormal_circadian_rhythm1.28724106
47MP0003787_abnormal_imprinting1.28534303
48MP0005551_abnormal_eye_electrophysiolog1.24834345
49MP0004858_abnormal_nervous_system1.24065626
50MP0003633_abnormal_nervous_system1.23979934
51MP0002909_abnormal_adrenal_gland1.20332546
52MP0004147_increased_porphyrin_level1.20318641
53MP0008877_abnormal_DNA_methylation1.20053715
54MP0001188_hyperpigmentation1.19532294
55MP0002229_neurodegeneration1.17370699
56MP0003631_nervous_system_phenotype1.14900287
57MP0002837_dystrophic_cardiac_calcinosis1.11801306
58MP0002638_abnormal_pupillary_reflex1.11362231
59MP0005645_abnormal_hypothalamus_physiol1.10491018
60MP0000751_myopathy1.09250586
61MP0006035_abnormal_mitochondrial_morpho1.04687485
62MP0000569_abnormal_digit_pigmentation1.04564790
63MP0004145_abnormal_muscle_electrophysio1.03590140
64MP0002152_abnormal_brain_morphology1.03000990
65MP0010386_abnormal_urinary_bladder1.01868134
66MP0004742_abnormal_vestibular_system0.97729365
67MP0008872_abnormal_physiological_respon0.97093847
68MP0000604_amyloidosis0.96484170
69MP0003634_abnormal_glial_cell0.96230062
70MP0003632_abnormal_nervous_system0.93386587
71MP0001963_abnormal_hearing_physiology0.93306185
72MP0005409_darkened_coat_color0.90439422
73MP0002752_abnormal_somatic_nervous0.89616846
74MP0002069_abnormal_eating/drinking_beha0.86983322
75MP0008874_decreased_physiological_sensi0.86167384
76MP0003690_abnormal_glial_cell0.85682765
77MP0002090_abnormal_vision0.85586269
78MP0002876_abnormal_thyroid_physiology0.85491065
79MP0005171_absent_coat_pigmentation0.84561853
80MP0005535_abnormal_body_temperature0.84541108
81MP0002102_abnormal_ear_morphology0.84379519
82MP0004085_abnormal_heartbeat0.83293649
83MP0001177_atelectasis0.80618867
84MP0005499_abnormal_olfactory_system0.78729478
85MP0005394_taste/olfaction_phenotype0.78729478
86MP0000013_abnormal_adipose_tissue0.78006966
87MP0000631_abnormal_neuroendocrine_gland0.77532056
88MP0001664_abnormal_digestion0.76074226
89MP0001485_abnormal_pinna_reflex0.74100650
90MP0005623_abnormal_meninges_morphology0.72458370
91MP0003121_genomic_imprinting0.70260074
92MP0005410_abnormal_fertilization0.66155868
93MP0002160_abnormal_reproductive_system0.63191889
94MP0006072_abnormal_retinal_apoptosis0.62976963
95MP0004484_altered_response_of0.62661693
96MP0003698_abnormal_male_reproductive0.62551942
97MP0004043_abnormal_pH_regulation0.61353598
98MP0010768_mortality/aging0.59650793
99MP0005448_abnormal_energy_balance0.58496281
100MP0001943_abnormal_respiration0.58008187
101MP0004215_abnormal_myocardial_fiber0.57004179
102MP0000750_abnormal_muscle_regeneration0.55600447
103MP0000747_muscle_weakness0.54638633
104MP0000026_abnormal_inner_ear0.54568418
105MP0004233_abnormal_muscle_weight0.53440945
106MP0004130_abnormal_muscle_cell0.53058966
107MP0003075_altered_response_to0.52198236
108MP0003137_abnormal_impulse_conducting0.50029874
109MP0003861_abnormal_nervous_system0.47700262
110MP0005253_abnormal_eye_physiology0.47696638
111MP0003956_abnormal_body_size0.47405480
112MP0002082_postnatal_lethality0.47023440
113MP0010770_preweaning_lethality0.47023440
114MP0010769_abnormal_survival0.46419028
115MP0002751_abnormal_autonomic_nervous0.43024751

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.71867229
2Myokymia (HP:0002411)6.06424475
3Focal seizures (HP:0007359)5.67175082
4Epileptic encephalopathy (HP:0200134)5.12428490
5Atonic seizures (HP:0010819)5.06971671
6Visual hallucinations (HP:0002367)4.52813041
7Febrile seizures (HP:0002373)4.37687238
8Absence seizures (HP:0002121)4.32109804
9Dialeptic seizures (HP:0011146)4.13866046
10Generalized tonic-clonic seizures (HP:0002069)3.86903646
11Progressive cerebellar ataxia (HP:0002073)3.78859597
12Neurofibrillary tangles (HP:0002185)3.69602605
13Supranuclear gaze palsy (HP:0000605)3.65789187
14Hyperventilation (HP:0002883)3.64606476
15Cerebral inclusion bodies (HP:0100314)3.54342960
16Broad-based gait (HP:0002136)3.42034482
17Dysmetria (HP:0001310)3.31601342
18Dysdiadochokinesis (HP:0002075)3.10864530
19Gaze-evoked nystagmus (HP:0000640)3.05832428
20Action tremor (HP:0002345)3.01773645
21Ankle clonus (HP:0011448)2.99701017
22Scanning speech (HP:0002168)2.97395935
23Abnormality of the corticospinal tract (HP:0002492)2.95623512
24Limb dystonia (HP:0002451)2.94670932
25Poor eye contact (HP:0000817)2.89718733
26Impaired vibration sensation in the lower limbs (HP:0002166)2.88246394
27Amblyopia (HP:0000646)2.87842157
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.84869457
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.84869457
30Insidious onset (HP:0003587)2.82877861
31Termporal pattern (HP:0011008)2.82877861
32Truncal ataxia (HP:0002078)2.78855157
33Anxiety (HP:0000739)2.78567101
34Pheochromocytoma (HP:0002666)2.78077024
35Abnormal eating behavior (HP:0100738)2.73755996
36Spastic gait (HP:0002064)2.68152466
37Depression (HP:0000716)2.62486879
38Morphological abnormality of the pyramidal tract (HP:0002062)2.59301860
39Impaired social interactions (HP:0000735)2.58224654
40Abnormal social behavior (HP:0012433)2.58224654
41Cerebral hypomyelination (HP:0006808)2.57209812
42Drooling (HP:0002307)2.57011321
43Excessive salivation (HP:0003781)2.57011321
44Progressive inability to walk (HP:0002505)2.55530750
45Urinary urgency (HP:0000012)2.54077826
46Abnormality of binocular vision (HP:0011514)2.54071175
47Diplopia (HP:0000651)2.54071175
48Genetic anticipation (HP:0003743)2.52142368
49Amyotrophic lateral sclerosis (HP:0007354)2.52061151
50Dysmetric saccades (HP:0000641)2.51366119
51Epileptiform EEG discharges (HP:0011182)2.51335075
52Urinary bladder sphincter dysfunction (HP:0002839)2.49470747
53Mutism (HP:0002300)2.47417267
54Hemiparesis (HP:0001269)2.45634159
55Retinal dysplasia (HP:0007973)2.44063268
56Neuroendocrine neoplasm (HP:0100634)2.41885139
57EEG with generalized epileptiform discharges (HP:0011198)2.36715353
58Polyphagia (HP:0002591)2.35930732
59Gait imbalance (HP:0002141)2.35688471
60Postural instability (HP:0002172)2.35112146
61Absent speech (HP:0001344)2.32289126
62Intention tremor (HP:0002080)2.30848589
63Torticollis (HP:0000473)2.25712751
64Inability to walk (HP:0002540)2.24736822
65Bradykinesia (HP:0002067)2.23118394
66Autoamputation (HP:0001218)2.22791877
67Clonus (HP:0002169)2.21242192
68Generalized myoclonic seizures (HP:0002123)2.19028220
69Delusions (HP:0000746)2.18530444
70Poor coordination (HP:0002370)2.18458777
71Clumsiness (HP:0002312)2.18132698
72Hemiplegia (HP:0002301)2.16781070
73Hypsarrhythmia (HP:0002521)2.14359377
74Spastic tetraparesis (HP:0001285)2.10375100
75Neuronal loss in central nervous system (HP:0002529)2.06723360
76Abnormal hair whorl (HP:0010721)2.06283481
77Lower limb muscle weakness (HP:0007340)2.06188993
78Type II lissencephaly (HP:0007260)2.05711476
79Lissencephaly (HP:0001339)2.04171635
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03906763
81Intellectual disability, profound (HP:0002187)2.03502180
82Focal dystonia (HP:0004373)2.03374436
83Psychosis (HP:0000709)2.02899445
84Incomplete penetrance (HP:0003829)2.02596682
85Blue irides (HP:0000635)2.01618653
86Stereotypic behavior (HP:0000733)2.00749533
87Abnormality of the lower motor neuron (HP:0002366)2.00486405
88Medial flaring of the eyebrow (HP:0010747)1.99257360
89Paraplegia (HP:0010550)1.99056763
90Congenital primary aphakia (HP:0007707)1.97561018
91CNS hypomyelination (HP:0003429)1.96936530
92Acute necrotizing encephalopathy (HP:0006965)1.96781459
93Gait ataxia (HP:0002066)1.95496645
94Status epilepticus (HP:0002133)1.95240394
95Fetal akinesia sequence (HP:0001989)1.94441453
96Specific learning disability (HP:0001328)1.94333480
97Papilledema (HP:0001085)1.93868094
98Hypoventilation (HP:0002791)1.91958720
99Abnormality of ocular smooth pursuit (HP:0000617)1.91010644
100Ventricular fibrillation (HP:0001663)1.90275465
101Craniofacial dystonia (HP:0012179)1.89341236
102Impaired smooth pursuit (HP:0007772)1.89064526
103Horizontal nystagmus (HP:0000666)1.88815362
104Akinesia (HP:0002304)1.88749146
105Genital tract atresia (HP:0001827)1.88480699
106Vaginal atresia (HP:0000148)1.87269143
107Impaired vibratory sensation (HP:0002495)1.84786616
108Abnormality of salivation (HP:0100755)1.83442561
109Spastic tetraplegia (HP:0002510)1.82664160
110Failure to thrive in infancy (HP:0001531)1.82187806
111Nephrogenic diabetes insipidus (HP:0009806)1.82081899
112Peripheral hypomyelination (HP:0007182)1.80939983
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.80880184
114Absent/shortened dynein arms (HP:0200106)1.80880184
115Abnormal mitochondria in muscle tissue (HP:0008316)1.79653856
116Rapidly progressive (HP:0003678)1.79521937
117Cerebral hemorrhage (HP:0001342)1.79041684
118Rigidity (HP:0002063)1.79033672
119Abnormality of saccadic eye movements (HP:0000570)1.78708968
120Megalencephaly (HP:0001355)1.78418142
121Protruding tongue (HP:0010808)1.77883660
122Progressive macrocephaly (HP:0004481)1.77852949
123Insomnia (HP:0100785)1.77190703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.56194669
2EPHA44.36218431
3MAP3K92.99270266
4MAP3K42.98384612
5MAP2K72.68692978
6MARK12.59935855
7CASK2.56226934
8MINK12.40592413
9RIPK42.33226571
10MAP3K122.30569423
11DAPK22.28370499
12PNCK2.25166258
13FRK2.07918202
14NTRK21.96254139
15MAP4K21.94935730
16INSRR1.92425704
17PLK21.90586653
18MAP2K41.83312923
19PAK61.82325206
20NTRK11.81396996
21TRIM281.78439442
22KSR21.65468685
23CDK191.64184549
24TNIK1.62459533
25GRK51.61651367
26OXSR11.59328964
27PRPF4B1.52761387
28CDK51.49284097
29DAPK11.44523750
30STK391.38378020
31ARAF1.37996690
32FES1.32190774
33CAMK2B1.30605749
34CAMK2A1.30551272
35MAPK131.29801385
36CSNK1A1L1.23526539
37CAMKK11.22315598
38STK241.21964552
39PTK2B1.20093102
40BMPR21.20038463
41PRKCG1.18372239
42KSR11.15920207
43NME11.13004810
44ZAK1.12991876
45ERBB31.12161442
46UHMK11.11043742
47CSNK1G11.07083619
48CAMKK21.04847450
49PRKD30.99458443
50MAP3K130.97968321
51SGK2230.97750605
52SGK4940.97750605
53FGR0.97741582
54CSNK1G20.95952602
55SIK20.93954620
56CDK140.92036044
57CDK180.91962454
58CAMK40.91558204
59CDK150.90549804
60BCR0.89768008
61CAMK2D0.89718932
62MAPKAPK50.86744107
63PHKG20.81602591
64PHKG10.81602591
65PRKCE0.79244212
66PAK30.78347988
67CDK11A0.78319112
68DYRK1A0.77049242
69CAMK2G0.75900976
70STK380.75130429
71CAMK10.75097859
72MARK20.70907198
73MAP3K20.70656993
74STK110.68635299
75AKT30.67037865
76PKN10.66861732
77TYRO30.65678465
78SGK10.64353370
79WNK40.63461126
80ROCK20.63200370
81CCNB10.62621011
82RAF10.62452859
83PRKCH0.62314965
84GRK70.60626528
85WNK10.59938355
86CSNK1G30.57794892
87RET0.57614670
88LATS20.52567959
89CAMK1G0.52348323
90PDPK10.52345082
91PRKAA10.52049438
92DAPK30.51896026
93WNK30.51451149
94PDK10.48435543
95MAP3K10.48273321
96FER0.47990938
97FYN0.46026116
98PINK10.45414289
99SGK20.45055135
100LIMK10.44973418
101CSNK1D0.44433017
102PRKCZ0.44363667
103NEK60.43921878
104RPS6KA50.43216887
105MAP2K10.42406789
106TNK20.42083345
107MAPK120.40680083
108RPS6KA30.40342034
109PRKACA0.40139424
110ADRBK20.39578306
111ADRBK10.39178314
112PRKCA0.39122057
113MAPK100.38878107
114EPHA30.38742478
115MAP3K60.38407852
116MAP3K110.37125267
117OBSCN0.36362590
118BRD40.34378939
119PRKG10.33922819
120SGK30.33781659
121DYRK20.33154594
122BMPR1B0.32452028
123TESK20.29925220
124CDK30.29705043
125FGFR20.29690924

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00242935
2Synaptic vesicle cycle_Homo sapiens_hsa047213.45424039
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91135483
4GABAergic synapse_Homo sapiens_hsa047272.87434298
5Morphine addiction_Homo sapiens_hsa050322.64694616
6Circadian entrainment_Homo sapiens_hsa047132.63783540
7Glutamatergic synapse_Homo sapiens_hsa047242.56578737
8Amphetamine addiction_Homo sapiens_hsa050312.50212270
9Long-term potentiation_Homo sapiens_hsa047202.49987578
10Olfactory transduction_Homo sapiens_hsa047402.43504427
11Collecting duct acid secretion_Homo sapiens_hsa049662.41451621
12Dopaminergic synapse_Homo sapiens_hsa047282.22921052
13Salivary secretion_Homo sapiens_hsa049702.11881972
14Taste transduction_Homo sapiens_hsa047422.00542845
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95499224
16Serotonergic synapse_Homo sapiens_hsa047261.93172467
17Insulin secretion_Homo sapiens_hsa049111.84997749
18Long-term depression_Homo sapiens_hsa047301.84634763
19Renin secretion_Homo sapiens_hsa049241.81372517
20Cholinergic synapse_Homo sapiens_hsa047251.80646208
21Gastric acid secretion_Homo sapiens_hsa049711.77159171
22Cocaine addiction_Homo sapiens_hsa050301.73004219
23Oxidative phosphorylation_Homo sapiens_hsa001901.62758947
24Vibrio cholerae infection_Homo sapiens_hsa051101.57909803
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57442328
26Oxytocin signaling pathway_Homo sapiens_hsa049211.56142845
27Calcium signaling pathway_Homo sapiens_hsa040201.55816363
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48047422
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43718542
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34557471
31Cardiac muscle contraction_Homo sapiens_hsa042601.32035162
32Alzheimers disease_Homo sapiens_hsa050101.27120020
33GnRH signaling pathway_Homo sapiens_hsa049121.26080835
34Gap junction_Homo sapiens_hsa045401.24518208
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23780630
36Vitamin B6 metabolism_Homo sapiens_hsa007501.19956581
37Parkinsons disease_Homo sapiens_hsa050121.18688617
38Axon guidance_Homo sapiens_hsa043601.18595258
39cAMP signaling pathway_Homo sapiens_hsa040241.11936054
40Phototransduction_Homo sapiens_hsa047441.10071423
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08779603
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08759540
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08062164
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01901576
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99422425
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.97744109
47Estrogen signaling pathway_Homo sapiens_hsa049150.96392150
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94521265
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90436252
50Melanogenesis_Homo sapiens_hsa049160.87547591
51ErbB signaling pathway_Homo sapiens_hsa040120.83610825
52Pancreatic secretion_Homo sapiens_hsa049720.78769268
53Glioma_Homo sapiens_hsa052140.76866819
54Type II diabetes mellitus_Homo sapiens_hsa049300.75085646
55Huntingtons disease_Homo sapiens_hsa050160.71622860
56Nitrogen metabolism_Homo sapiens_hsa009100.71522146
57Dorso-ventral axis formation_Homo sapiens_hsa043200.66841121
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.66454313
59Oocyte meiosis_Homo sapiens_hsa041140.64300639
60Dilated cardiomyopathy_Homo sapiens_hsa054140.63830120
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63817815
62Thyroid hormone synthesis_Homo sapiens_hsa049180.63668220
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61794645
64Rheumatoid arthritis_Homo sapiens_hsa053230.61579253
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61282592
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61073826
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58245513
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57992337
69MAPK signaling pathway_Homo sapiens_hsa040100.57943443
70Choline metabolism in cancer_Homo sapiens_hsa052310.55084870
71Ras signaling pathway_Homo sapiens_hsa040140.53816445
72Alcoholism_Homo sapiens_hsa050340.53599575
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.49212861
74Systemic lupus erythematosus_Homo sapiens_hsa053220.46035237
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45725087
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44362674
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44343592
78VEGF signaling pathway_Homo sapiens_hsa043700.42620184
79mTOR signaling pathway_Homo sapiens_hsa041500.42360959
80Glucagon signaling pathway_Homo sapiens_hsa049220.41341502
81Fatty acid biosynthesis_Homo sapiens_hsa000610.41229511
82Inositol phosphate metabolism_Homo sapiens_hsa005620.40801441
83African trypanosomiasis_Homo sapiens_hsa051430.40769445
84Histidine metabolism_Homo sapiens_hsa003400.40259126
85Ether lipid metabolism_Homo sapiens_hsa005650.39799418
86Ovarian steroidogenesis_Homo sapiens_hsa049130.39430567
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39296207
88Rap1 signaling pathway_Homo sapiens_hsa040150.37959576
89Type I diabetes mellitus_Homo sapiens_hsa049400.37354490
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36197153
91Phagosome_Homo sapiens_hsa041450.35398534
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34929479
93Fatty acid elongation_Homo sapiens_hsa000620.34873548
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.34398944
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34332585
96Prion diseases_Homo sapiens_hsa050200.34296155
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32320596
98Bile secretion_Homo sapiens_hsa049760.32217654
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31797286
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.31599993
101Endocytosis_Homo sapiens_hsa041440.31036223
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30455570
103Renal cell carcinoma_Homo sapiens_hsa052110.29685108
104Mineral absorption_Homo sapiens_hsa049780.29662688
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28351307
106Wnt signaling pathway_Homo sapiens_hsa043100.28182776
107Butanoate metabolism_Homo sapiens_hsa006500.27748116
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26461397
109Circadian rhythm_Homo sapiens_hsa047100.26215675
110AMPK signaling pathway_Homo sapiens_hsa041520.22167788
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22066038
112Arginine and proline metabolism_Homo sapiens_hsa003300.19720055
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16357778
114Regulation of autophagy_Homo sapiens_hsa041400.15645403
115Tight junction_Homo sapiens_hsa045300.15560254
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15088211
117Selenocompound metabolism_Homo sapiens_hsa004500.14455866
118Arginine biosynthesis_Homo sapiens_hsa002200.14212740

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