GPR65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.60840829
2antigen processing and presentation of endogenous antigen (GO:0019883)5.08168546
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.03805066
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.03805066
5positive regulation of gamma-delta T cell activation (GO:0046645)4.77871309
6detection of molecule of bacterial origin (GO:0032490)4.56454737
7macrophage activation involved in immune response (GO:0002281)4.53988035
8regulation of B cell receptor signaling pathway (GO:0050855)4.50768594
9neutrophil activation involved in immune response (GO:0002283)4.33373481
10regulation of interleukin-12 biosynthetic process (GO:0045075)4.32103621
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28726060
12immunoglobulin mediated immune response (GO:0016064)4.19911698
13detection of other organism (GO:0098543)4.18984134
14microglial cell activation (GO:0001774)3.99559052
15myeloid dendritic cell activation (GO:0001773)3.98359180
16myeloid dendritic cell differentiation (GO:0043011)3.97423790
17detection of external biotic stimulus (GO:0098581)3.94760535
18positive regulation of interferon-alpha production (GO:0032727)3.92760368
19defense response to protozoan (GO:0042832)3.90417460
20regulation of interferon-alpha production (GO:0032647)3.89759791
21negative regulation of T cell mediated immunity (GO:0002710)3.87668219
22interferon-gamma production (GO:0032609)3.87211623
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87132963
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.84957432
25negative thymic T cell selection (GO:0045060)3.82829803
26detection of bacterium (GO:0016045)3.81524818
27negative T cell selection (GO:0043383)3.79709620
28positive regulation of antigen processing and presentation (GO:0002579)3.79443234
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.74915281
30positive regulation of B cell differentiation (GO:0045579)3.67438804
31type I interferon signaling pathway (GO:0060337)3.65363612
32cellular response to type I interferon (GO:0071357)3.65363612
33macrophage activation (GO:0042116)3.63585299
34response to type I interferon (GO:0034340)3.63340360
35response to protozoan (GO:0001562)3.63116474
36response to peptidoglycan (GO:0032494)3.59410443
37interferon-gamma-mediated signaling pathway (GO:0060333)3.57436904
38negative regulation of cell killing (GO:0031342)3.57106178
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57106178
40detection of biotic stimulus (GO:0009595)3.55998329
41mast cell activation (GO:0045576)3.55236568
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.54251832
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.51433979
44regulation of T cell tolerance induction (GO:0002664)3.50905697
45regulation of gamma-delta T cell differentiation (GO:0045586)3.48857912
46modulation by symbiont of host immune response (GO:0052553)3.45871336
47positive regulation by symbiont of host defense response (GO:0052509)3.45871336
48modulation by symbiont of host defense response (GO:0052031)3.45871336
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45871336
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45871336
51positive regulation by organism of defense response of other organism involved in symbiotic interact3.45871336
52regulation of interferon-beta biosynthetic process (GO:0045357)3.45144614
53regulation of B cell differentiation (GO:0045577)3.43758444
54negative regulation of leukocyte mediated immunity (GO:0002704)3.41921158
55B cell mediated immunity (GO:0019724)3.40915183
56response to host immune response (GO:0052572)3.40805557
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40805557
58tolerance induction (GO:0002507)3.40614123
59regulation of T cell mediated cytotoxicity (GO:0001914)3.39727159
60activated T cell proliferation (GO:0050798)3.39112374
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37772076
62respiratory burst (GO:0045730)3.37452785
63production of molecular mediator involved in inflammatory response (GO:0002532)3.36257225
64neutrophil activation (GO:0042119)3.35636599
65leukocyte aggregation (GO:0070486)3.35436244
66regulation of antigen processing and presentation (GO:0002577)3.35074438
67regulation of gamma-delta T cell activation (GO:0046643)3.33123717
68regulation of regulatory T cell differentiation (GO:0045589)3.32928667
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29390516
70NIK/NF-kappaB signaling (GO:0038061)3.28178600
71positive T cell selection (GO:0043368)3.27363716
72regulation of alpha-beta T cell proliferation (GO:0046640)3.26516808
73positive thymic T cell selection (GO:0045059)3.23572673
74dendritic cell differentiation (GO:0097028)3.22478720
75positive regulation of alpha-beta T cell proliferation (GO:0046641)3.21806247
76regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21376300
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.20796448
78dendritic cell chemotaxis (GO:0002407)3.20625257
79T cell migration (GO:0072678)3.20500335
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19405305
81granulocyte activation (GO:0036230)3.19196613
82positive regulation of natural killer cell differentiation (GO:0032825)3.18259059
83positive regulation of macrophage differentiation (GO:0045651)3.17757131
84B cell receptor signaling pathway (GO:0050853)3.16735262
85dendritic cell migration (GO:0036336)3.13598977
86cellular response to interferon-beta (GO:0035458)3.12999383
87regulation of mast cell activation (GO:0033003)3.12558701
88regulation of natural killer cell mediated immunity (GO:0002715)3.10087975
89regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10087975
90regulation of T-helper 1 cell differentiation (GO:0045625)3.08149796
91response to interferon-beta (GO:0035456)3.07440369
92regulation of mast cell degranulation (GO:0043304)3.05866757
93cellular extravasation (GO:0045123)3.05762303
94regulation of hypersensitivity (GO:0002883)3.05579918
95response to muramyl dipeptide (GO:0032495)3.05393553
96response to interleukin-15 (GO:0070672)3.05049879
97positive regulation of defense response to virus by host (GO:0002230)3.04530848
98response to interferon-alpha (GO:0035455)3.04021221
99neutrophil mediated immunity (GO:0002446)3.03216086
100regulation of activation of Janus kinase activity (GO:0010533)3.03207383
101positive regulation of interleukin-12 production (GO:0032735)3.02570784
102response to host (GO:0075136)3.01942842
103response to host defenses (GO:0052200)3.01942842
104response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01942842
105leukocyte degranulation (GO:0043299)3.01928955
106cellular response to interleukin-15 (GO:0071350)3.01221289
107positive regulation of isotype switching (GO:0045830)3.00186770
108negative regulation of interleukin-17 production (GO:0032700)2.98659220
109regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97601477
110myeloid cell activation involved in immune response (GO:0002275)2.97552850
111positive regulation of interleukin-2 production (GO:0032743)2.97240277
112antigen processing and presentation via MHC class Ib (GO:0002475)2.97200001
113positive regulation of tolerance induction (GO:0002645)2.96631323
114antigen receptor-mediated signaling pathway (GO:0050851)2.94093545
115positive regulation of B cell mediated immunity (GO:0002714)2.93418342
116positive regulation of immunoglobulin mediated immune response (GO:0002891)2.93418342
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93243413
118T-helper 1 type immune response (GO:0042088)2.92326534
119regulation of T cell receptor signaling pathway (GO:0050856)2.92018040
120thymic T cell selection (GO:0045061)2.90696034
121regulation of tolerance induction (GO:0002643)2.89672529
122positive regulation of T-helper 1 type immune response (GO:0002827)2.89446520
123regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88779775
124negative regulation of adaptive immune response (GO:0002820)2.88549895
125negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88346353
126myeloid leukocyte activation (GO:0002274)2.86950948
127positive regulation of interferon-beta production (GO:0032728)2.86643000
128T cell selection (GO:0045058)2.85865298
129regulation of interleukin-2 biosynthetic process (GO:0045076)2.84500102
130negative regulation of B cell proliferation (GO:0030889)2.84054752
131positive regulation of mast cell activation (GO:0033005)2.83910255
132T cell activation involved in immune response (GO:0002286)2.83472518
133positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83245214
134positive regulation of DNA recombination (GO:0045911)2.82638433
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81255427
136mature B cell differentiation (GO:0002335)2.80590107
137negative regulation of interleukin-12 production (GO:0032695)2.79958753
138positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79452767
139pinocytosis (GO:0006907)2.78871554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.82747486
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.53876858
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.32883059
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.76433795
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.55300595
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.07914159
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.66660563
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60052299
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.52996105
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34645789
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34578096
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.25035876
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.21176469
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11154697
15E2F7_22180533_ChIP-Seq_HELA_Human3.05866179
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79575812
17SCL_19346495_ChIP-Seq_HPC-7_Human2.66303223
18* MYB_26560356_Chip-Seq_TH2_Human2.59700334
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.58347683
20SPI1_23547873_ChIP-Seq_NB4_Human2.52537079
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47770673
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46992203
23RUNX_20019798_ChIP-Seq_JUKART_Human2.39914524
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35310596
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31707315
26* MAF_26560356_Chip-Seq_TH1_Human2.23656475
27* MYB_26560356_Chip-Seq_TH1_Human2.13545747
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07371064
29* VDR_21846776_ChIP-Seq_THP-1_Human2.06129233
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04755457
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03609298
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99843336
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99014330
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.98706829
35* VDR_24763502_ChIP-Seq_THP-1_Human1.97709395
36MYC_22102868_ChIP-Seq_BL_Human1.96605660
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82008775
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.79523511
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76727776
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72179031
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66915271
42PU_27001747_Chip-Seq_BMDM_Mouse1.65980172
43* UTX_26944678_Chip-Seq_JUKART_Human1.63717198
44SPI1_23127762_ChIP-Seq_K562_Human1.58919568
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57114388
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53959582
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51446447
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48419743
49GATA3_27048872_Chip-Seq_THYMUS_Human1.48254967
50GATA1_22025678_ChIP-Seq_K562_Human1.46376049
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43811378
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43780987
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40847125
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36888009
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36400371
56* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35718790
57MAF_26560356_Chip-Seq_TH2_Human1.34788678
58TCF7_22412390_ChIP-Seq_EML_Mouse1.33706299
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31556916
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30981190
61GATA3_26560356_Chip-Seq_TH2_Human1.30634345
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27315737
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23549015
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22599530
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22270577
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21390244
67* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21245330
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17357969
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16557250
70* VDR_24787735_ChIP-Seq_THP-1_Human1.14089522
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14021215
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10898844
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07476466
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07468680
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06202191
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05793136
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05306743
78SMRT_27268052_Chip-Seq_Bcells_Human1.05301327
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04494408
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02553872
81VDR_23849224_ChIP-Seq_CD4+_Human1.00896064
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99941867
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99460438
84E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99341668
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95206477
86GATA3_26560356_Chip-Seq_TH1_Human0.91207056
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90973702
88FLI1_27457419_Chip-Seq_LIVER_Mouse0.89639288
89EGR1_19032775_ChIP-ChIP_M12_Human0.89326120
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87262080
91TFEB_21752829_ChIP-Seq_HELA_Human0.86221997
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.86161821
93ELK1_19687146_ChIP-ChIP_HELA_Human0.85668133
94GATA1_19941826_ChIP-Seq_K562_Human0.83804338
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83080302
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80051689
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79710719
98GATA2_19941826_ChIP-Seq_K562_Human0.78015209
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76525968
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75905578
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73326931
102FOXP3_21729870_ChIP-Seq_TREG_Human0.72473775
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72295802
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71767299
105KDM2B_26808549_Chip-Seq_DND41_Human0.71562067
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70725496
107SMAD_19615063_ChIP-ChIP_OVARY_Human0.70499517
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70035679
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69779050
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69100531
111GABP_17652178_ChIP-ChIP_JURKAT_Human0.68807552
112GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.68186843
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68170183
114* PRDM14_20953172_ChIP-Seq_ESCs_Human0.67682575
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.66823143
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.66771682
117SPI1_20517297_ChIP-Seq_HL60_Human0.66672380
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66577512
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.63520589
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.62617690
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.60748587
122* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57928129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.13440204
2MP0005671_abnormal_response_to3.81339991
3MP0009785_altered_susceptibility_to3.67033696
4MP0003436_decreased_susceptibility_to3.37285949
5MP0000685_abnormal_immune_system3.33090468
6MP0002148_abnormal_hypersensitivity_rea3.31463174
7MP0005000_abnormal_immune_tolerance3.22590490
8MP0001790_abnormal_immune_system3.18924838
9MP0005387_immune_system_phenotype3.18924838
10MP0001800_abnormal_humoral_immune3.04713324
11MP0005025_abnormal_response_to2.92952176
12* MP0002452_abnormal_antigen_presenting2.79349188
13* MP0002723_abnormal_immune_serum2.74518645
14* MP0002419_abnormal_innate_immunity2.74032304
15MP0003303_peritoneal_inflammation2.61581505
16MP0003724_increased_susceptibility_to2.60225956
17* MP0002420_abnormal_adaptive_immunity2.59032428
18* MP0001819_abnormal_immune_cell2.58266295
19MP0003763_abnormal_thymus_physiology2.44204388
20MP0002166_altered_tumor_susceptibility2.31786387
21MP0006082_CNS_inflammation2.29452825
22MP0002405_respiratory_system_inflammati2.25344107
23MP0002398_abnormal_bone_marrow2.19021406
24MP0009333_abnormal_splenocyte_physiolog2.18169278
25MP0001853_heart_inflammation2.11528579
26MP0000716_abnormal_immune_system2.10528588
27MP0002396_abnormal_hematopoietic_system2.05568393
28MP0005464_abnormal_platelet_physiology2.03714597
29MP0004510_myositis2.02907615
30MP0003300_gastrointestinal_ulcer2.00398434
31MP0010155_abnormal_intestine_physiology1.98894882
32MP0002006_tumorigenesis1.97818321
33MP0001845_abnormal_inflammatory_respons1.83701517
34MP0000689_abnormal_spleen_morphology1.82703724
35MP0001873_stomach_inflammation1.78443268
36MP0002722_abnormal_immune_system1.76231985
37MP0002429_abnormal_blood_cell1.73167018
38MP0005058_abnormal_lysosome_morphology1.72713685
39MP0005310_abnormal_salivary_gland1.69998607
40MP0001533_abnormal_skeleton_physiology1.62241352
41MP0004947_skin_inflammation1.57283241
42MP0004381_abnormal_hair_follicle1.56792590
43MP0000858_altered_metastatic_potential1.52091371
44MP0008469_abnormal_protein_level1.49540555
45MP0003448_altered_tumor_morphology1.48894143
46MP0001545_abnormal_hematopoietic_system1.48583361
47MP0005397_hematopoietic_system_phenotyp1.48583361
48MP0000703_abnormal_thymus_morphology1.46621513
49MP0002138_abnormal_hepatobiliary_system1.43842744
50MP0003866_abnormal_defecation1.41828373
51MP0000465_gastrointestinal_hemorrhage1.40752486
52MP0003191_abnormal_cellular_cholesterol1.36877496
53MP0005174_abnormal_tail_pigmentation1.35882397
54MP0004808_abnormal_hematopoietic_stem1.33995522
55MP0003172_abnormal_lysosome_physiology1.32451895
56MP0009840_abnormal_foam_cell1.30363579
57MP0000490_abnormal_crypts_of1.29878698
58MP0008057_abnormal_DNA_replication1.28441690
59MP0009764_decreased_sensitivity_to1.28394014
60MP0002933_joint_inflammation1.25958582
61MP0002277_abnormal_respiratory_mucosa1.24921442
62MP0008260_abnormal_autophagy1.23104059
63MP0004883_abnormal_blood_vessel1.19108597
64MP0000343_altered_response_to1.16587200
65MP0005451_abnormal_body_composition1.03672856
66MP0001348_abnormal_lacrimal_gland1.03632028
67MP0003075_altered_response_to1.02949085
68MP0008007_abnormal_cellular_replicative1.02755572
69MP0002998_abnormal_bone_remodeling1.01021238
70MP0003690_abnormal_glial_cell0.97526341
71MP0005164_abnormal_response_to0.97328185
72MP0009278_abnormal_bone_marrow0.96070346
73MP0005075_abnormal_melanosome_morpholog0.91883844
74MP0009763_increased_sensitivity_to0.90957203
75MP0010307_abnormal_tumor_latency0.90030607
76MP0003045_fibrosis0.88540567
77MP0003806_abnormal_nucleotide_metabolis0.88095382
78MP0002019_abnormal_tumor_incidence0.85894681
79MP0000015_abnormal_ear_pigmentation0.82647303
80MP0000604_amyloidosis0.81873622
81MP0003183_abnormal_peptide_metabolism0.75500267
82MP0000569_abnormal_digit_pigmentation0.74241628
83MP0005166_decreased_susceptibility_to0.73879497
84MP0002132_abnormal_respiratory_system0.73343000
85MP0001851_eye_inflammation0.72450109
86MP0002254_reproductive_system_inflammat0.70885993
87MP0000249_abnormal_blood_vessel0.70875381
88MP0002163_abnormal_gland_morphology0.69144888
89MP0001663_abnormal_digestive_system0.68130650
90MP0000371_diluted_coat_color0.68006019
91MP0005390_skeleton_phenotype0.67146188
92MP0003186_abnormal_redox_activity0.66122866
93MP0003195_calcinosis0.64296750
94MP0003828_pulmonary_edema0.64013638
95MP0008004_abnormal_stomach_pH0.63342393
96MP0004782_abnormal_surfactant_physiolog0.62810597
97MP0002095_abnormal_skin_pigmentation0.62402239
98MP0003787_abnormal_imprinting0.60480956
99MP0005076_abnormal_cell_differentiation0.58597917
100MP0008873_increased_physiological_sensi0.58244639
101MP0005167_abnormal_blood-brain_barrier0.57645665
102MP0002009_preneoplasia0.56577331
103MP0000920_abnormal_myelination0.55441602
104MP0003656_abnormal_erythrocyte_physiolo0.53593395
105MP0001986_abnormal_taste_sensitivity0.53067220
106MP0003795_abnormal_bone_structure0.52937793
107MP0009765_abnormal_xenobiotic_induced0.52044698
108MP0000609_abnormal_liver_physiology0.51941002
109MP0002136_abnormal_kidney_physiology0.51846991
110MP0002877_abnormal_melanocyte_morpholog0.48949970
111MP0004484_altered_response_of0.47413730
112MP0002693_abnormal_pancreas_physiology0.46099059
113MP0000313_abnormal_cell_death0.45820564
114MP0003252_abnormal_bile_duct0.45333170
115MP0003077_abnormal_cell_cycle0.45104205
116MP0003693_abnormal_embryo_hatching0.44997437
117MP0010352_gastrointestinal_tract_polyps0.44946788

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.68159704
2Myositis (HP:0100614)5.65426880
3Eczematoid dermatitis (HP:0000976)5.18315601
4Recurrent bacterial skin infections (HP:0005406)5.02666476
5Elevated erythrocyte sedimentation rate (HP:0003565)4.95891928
6Optic neuritis (HP:0100653)4.75407058
7Retrobulbar optic neuritis (HP:0100654)4.75407058
8Orchitis (HP:0100796)4.56828161
9Recurrent fungal infections (HP:0002841)4.03028427
10Mediastinal lymphadenopathy (HP:0100721)3.94096367
11Recurrent viral infections (HP:0004429)3.85383734
12Abnormality of macrophages (HP:0004311)3.78265521
13Chronic otitis media (HP:0000389)3.76915570
14Recurrent gram-negative bacterial infections (HP:0005420)3.76359269
15Abnormality of T cell number (HP:0011839)3.72532055
16Thrombocytosis (HP:0001894)3.70847611
17Obstructive lung disease (HP:0006536)3.69294089
18Chronic obstructive pulmonary disease (HP:0006510)3.69294089
19T lymphocytopenia (HP:0005403)3.66345695
20Recurrent skin infections (HP:0001581)3.59704503
21Vasculitis (HP:0002633)3.56560280
22Meningitis (HP:0001287)3.52599867
23Pulmonary infiltrates (HP:0002113)3.45807803
24Vacuolated lymphocytes (HP:0001922)3.42033114
25Stomatitis (HP:0010280)3.36398388
26Recurrent cutaneous fungal infections (HP:0011370)3.31356328
27Chronic mucocutaneous candidiasis (HP:0002728)3.31356328
28Abnormality of T cells (HP:0002843)3.25934934
29Spontaneous hematomas (HP:0007420)3.23738299
30Systemic lupus erythematosus (HP:0002725)3.21943217
31Recurrent bronchitis (HP:0002837)3.20908401
32Keratoconjunctivitis sicca (HP:0001097)3.17607662
33IgM deficiency (HP:0002850)3.17349198
34Autoimmune thrombocytopenia (HP:0001973)3.14418005
35Arterial thrombosis (HP:0004420)3.13098846
36Hemoptysis (HP:0002105)3.08781632
37Panhypogammaglobulinemia (HP:0003139)3.01881476
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.98277789
39IgG deficiency (HP:0004315)2.94323262
40Nasal polyposis (HP:0100582)2.90945823
41Gastrointestinal infarctions (HP:0005244)2.87590366
42Abnormality of the prostate (HP:0008775)2.86611241
43Keratoconjunctivitis (HP:0001096)2.86538386
44Gingivitis (HP:0000230)2.85880009
45Abnormality of liposaccharide metabolism (HP:0010968)2.84496251
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.84496251
47Abnormality of glycolipid metabolism (HP:0010969)2.84496251
48Encephalitis (HP:0002383)2.83944152
49Severe combined immunodeficiency (HP:0004430)2.83630628
50Basal ganglia calcification (HP:0002135)2.83602098
51Abnormality of T cell physiology (HP:0011840)2.83174331
52Inflammation of the large intestine (HP:0002037)2.82074372
53Pustule (HP:0200039)2.77359288
54Chronic diarrhea (HP:0002028)2.76073850
55Leukocytosis (HP:0001974)2.75583760
56Gastrointestinal inflammation (HP:0004386)2.71474272
57Eosinophilia (HP:0001880)2.70194499
58Thyroiditis (HP:0100646)2.69855375
59Increased IgM level (HP:0003496)2.69025804
60Combined immunodeficiency (HP:0005387)2.66742497
61Cellulitis (HP:0100658)2.65681423
62Abnormality of eosinophils (HP:0001879)2.64679483
63B lymphocytopenia (HP:0010976)2.63845861
64Abnormality of B cell number (HP:0010975)2.63845861
65Hypergammaglobulinemia (HP:0010702)2.61322215
66Chest pain (HP:0100749)2.60738726
67Periodontitis (HP:0000704)2.59219495
68Abnormality of the nasal mucosa (HP:0000433)2.54802203
69Glomerulonephritis (HP:0000099)2.52144215
70Polyneuropathy (HP:0001271)2.49978439
71Keratitis (HP:0000491)2.49893777
72Agammaglobulinemia (HP:0004432)2.48106678
73Granulocytopenia (HP:0001913)2.45671519
74Increased cerebral lipofuscin (HP:0011813)2.45077791
75Petechiae (HP:0000967)2.44615213
76Epistaxis (HP:0000421)2.44233628
77Gangrene (HP:0100758)2.43233464
78Gingival bleeding (HP:0000225)2.41259147
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.41064519
80Interstitial pulmonary disease (HP:0006530)2.40757479
81Disinhibition (HP:0000734)2.39812614
82Urticaria (HP:0001025)2.39740735
83Osteomyelitis (HP:0002754)2.38747247
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36010941
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.34531608
86Colitis (HP:0002583)2.34250333
87Lymphopenia (HP:0001888)2.33558857
88Pulmonary embolism (HP:0002204)2.31829392
89Recurrent pneumonia (HP:0006532)2.27027026
90Episodic fever (HP:0001954)2.22591278
91Agnosia (HP:0010524)2.21233631
92Dysostosis multiplex (HP:0000943)2.20749435
93Vertigo (HP:0002321)2.20555274
94IgA deficiency (HP:0002720)2.20421709
95Glomerulopathy (HP:0100820)2.19631868
96Increased IgE level (HP:0003212)2.18130259
97Prolonged bleeding time (HP:0003010)2.17470363
98Hypochromic anemia (HP:0001931)2.15821710
99Abnormality of the endocardium (HP:0004306)2.14094171
100Anorexia (HP:0002039)2.14078147
101Abnormality of the pleura (HP:0002103)2.13703287
102Recurrent sinusitis (HP:0011108)2.13673482
103Lymphoma (HP:0002665)2.13528289
104Joint swelling (HP:0001386)2.12830654
105Amaurosis fugax (HP:0100576)2.12672790
106Autoimmune hemolytic anemia (HP:0001890)2.10077848
107Skin ulcer (HP:0200042)2.08239495
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06311367
109Abnormality of the pericardium (HP:0001697)2.03870113
110Recurrent lower respiratory tract infections (HP:0002783)2.03711605
111Abnormality of the fingertips (HP:0001211)2.02447780
112Arthralgia (HP:0002829)1.98410041
113Hypochromic microcytic anemia (HP:0004840)1.97671811
114Thrombophlebitis (HP:0004418)1.97272605
115Amyloidosis (HP:0011034)1.95235949
116Acute hepatic failure (HP:0006554)1.91236877
117Sepsis (HP:0100806)1.89566051
118Restrictive lung disease (HP:0002091)1.89461776
119Premature loss of primary teeth (HP:0006323)1.88915927
120Skin rash (HP:0000988)1.88662035
121Hematochezia (HP:0002573)1.86956677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.51609731
2MAP4K14.03737356
3MAP3K143.39665928
4TBK13.13889748
5TYK22.87366058
6IRAK42.81402735
7BLK2.79209952
8IKBKE2.74845341
9KIT2.71908954
10TEC2.55791194
11JAK32.54786451
12IKBKB2.52925831
13ZAP702.35101766
14IRAK32.16388564
15ITK2.10590563
16BTK2.05640164
17JAK12.04864633
18TAOK31.89898263
19PIM21.88650304
20TGFBR21.85252038
21SYK1.82212726
22RIPK41.72904353
23CSF1R1.67779742
24FGR1.54389230
25LCK1.49847597
26NME21.48841610
27HCK1.48176449
28STK101.46061325
29CHUK1.45075395
30CSK1.35268686
31FES1.31492232
32FGFR41.29377996
33PIM11.28306225
34LYN1.24774773
35MST41.21660993
36NLK1.20104827
37NEK91.19048883
38FLT31.14020994
39EPHB11.03808448
40MAP2K31.03121971
41SIK31.02743983
42FRK1.02427974
43STK241.02067323
44CLK11.01929150
45GRK60.99403607
46JAK20.98804836
47FGFR30.94821460
48PRPF4B0.90895266
49RPS6KA40.90811877
50IRAK20.90357776
51EEF2K0.89734221
52MAP3K120.88937514
53EIF2AK20.87429018
54TAOK10.84359839
55GRK70.83725459
56LRRK20.82864233
57MAP3K10.82860604
58MATK0.82496055
59PDK10.81492457
60MAP2K60.81061979
61RIPK10.79595534
62MAP3K130.78850245
63BMPR20.73736406
64ERN10.71616448
65TNIK0.70356139
66IRAK10.65755006
67MAPK70.63493993
68SCYL20.62966688
69PRKCQ0.61909560
70KDR0.61238562
71EPHA30.61223853
72MAPK120.60577748
73MAP3K110.59192789
74MAP3K100.57721766
75MAP3K20.56892381
76TRPM70.56875237
77CAMKK10.54203149
78YES10.54189869
79PTK2B0.53540005
80EIF2AK30.52821002
81CDK60.51830636
82MAP2K20.51334206
83CDK40.50323633
84ADRBK20.49544591
85ACVR1B0.49225325
86NUAK10.49107063
87MUSK0.48030990
88TNK20.47981520
89PRKCD0.47870692
90PDPK10.45701630
91ABL10.45269775
92GRK50.44218976
93STK40.43838381
94MAPKAPK20.41624559
95CAMKK20.39927061
96ABL20.39708838
97RPS6KA50.39611357
98CDC42BPA0.39363731
99MARK20.38920482
100SGK20.37892343
101TESK20.37630498
102CDK190.37390872
103SIK20.37206268
104MAP3K50.36772605
105KSR20.36698256
106EGFR0.36512595
107HIPK20.34728650
108RPS6KA60.34429142
109TGFBR10.34347275
110IGF1R0.33702606
111PIK3CG0.32589420
112MAPK40.32530864
113RAF10.29527018
114SGK30.29238663
115TLK10.28875743
116BRD40.28726240
117CDK90.28418174
118PAK40.28194980
119PINK10.27998940
120MAPK110.27222482
121STK110.26700104
122WNK10.25859279
123FYN0.25769215
124STK30.25768939
125ATR0.25755656
126DAPK20.24030318
127MAP3K30.23991870
128CAMK40.23936919
129MARK30.23683868
130MAP3K70.23655548
131RPS6KC10.20853417
132RPS6KL10.20853417

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.51904686
2Graft-versus-host disease_Homo sapiens_hsa053323.11530543
3Leishmaniasis_Homo sapiens_hsa051403.01466740
4Primary immunodeficiency_Homo sapiens_hsa053403.01051975
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.99895842
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.73473085
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.59809272
8Measles_Homo sapiens_hsa051622.52041032
9Staphylococcus aureus infection_Homo sapiens_hsa051502.52026836
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38221882
11Antigen processing and presentation_Homo sapiens_hsa046122.38154786
12Osteoclast differentiation_Homo sapiens_hsa043802.26526443
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21404794
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.19835501
15Autoimmune thyroid disease_Homo sapiens_hsa053202.17203111
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14786444
17B cell receptor signaling pathway_Homo sapiens_hsa046621.94500395
18T cell receptor signaling pathway_Homo sapiens_hsa046601.83539831
19Type I diabetes mellitus_Homo sapiens_hsa049401.83163765
20Pertussis_Homo sapiens_hsa051331.80289505
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75504548
22Legionellosis_Homo sapiens_hsa051341.74988408
23Herpes simplex infection_Homo sapiens_hsa051681.72872314
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.71596306
25Hematopoietic cell lineage_Homo sapiens_hsa046401.70259882
26Asthma_Homo sapiens_hsa053101.62183092
27Tuberculosis_Homo sapiens_hsa051521.59901273
28Malaria_Homo sapiens_hsa051441.55753651
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54809940
30Influenza A_Homo sapiens_hsa051641.51165125
31Toxoplasmosis_Homo sapiens_hsa051451.48677316
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45657527
33Viral myocarditis_Homo sapiens_hsa054161.41706400
34Rheumatoid arthritis_Homo sapiens_hsa053231.34814475
35Other glycan degradation_Homo sapiens_hsa005111.34682092
36Chemokine signaling pathway_Homo sapiens_hsa040621.34572249
37Shigellosis_Homo sapiens_hsa051311.34111084
38Apoptosis_Homo sapiens_hsa042101.27487884
39Lysosome_Homo sapiens_hsa041421.26707771
40DNA replication_Homo sapiens_hsa030301.26063463
41TNF signaling pathway_Homo sapiens_hsa046681.25534732
42Salmonella infection_Homo sapiens_hsa051321.21326852
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.15331340
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14741735
45Hepatitis B_Homo sapiens_hsa051611.12982154
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02948353
47African trypanosomiasis_Homo sapiens_hsa051431.01809213
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99331126
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98881451
50Ribosome_Homo sapiens_hsa030100.97687681
51Acute myeloid leukemia_Homo sapiens_hsa052210.96312891
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.91531514
53Base excision repair_Homo sapiens_hsa034100.88803132
54Epstein-Barr virus infection_Homo sapiens_hsa051690.84727788
55Phagosome_Homo sapiens_hsa041450.81494452
56Hepatitis C_Homo sapiens_hsa051600.78631109
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77710548
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77703043
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72996080
60Platelet activation_Homo sapiens_hsa046110.68137854
61Non-small cell lung cancer_Homo sapiens_hsa052230.67683770
62Chronic myeloid leukemia_Homo sapiens_hsa052200.66224129
63Viral carcinogenesis_Homo sapiens_hsa052030.64525661
64Mismatch repair_Homo sapiens_hsa034300.63123135
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60716543
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60159538
67Dorso-ventral axis formation_Homo sapiens_hsa043200.57144683
68Pancreatic cancer_Homo sapiens_hsa052120.56954570
69Prolactin signaling pathway_Homo sapiens_hsa049170.56610248
70HTLV-I infection_Homo sapiens_hsa051660.56518381
71Proteasome_Homo sapiens_hsa030500.54829954
72Systemic lupus erythematosus_Homo sapiens_hsa053220.54055555
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51993146
74p53 signaling pathway_Homo sapiens_hsa041150.50685330
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.48619343
76Homologous recombination_Homo sapiens_hsa034400.48267277
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48232277
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.48096583
79Regulation of autophagy_Homo sapiens_hsa041400.45621907
80Non-homologous end-joining_Homo sapiens_hsa034500.45103817
81FoxO signaling pathway_Homo sapiens_hsa040680.39963826
82Collecting duct acid secretion_Homo sapiens_hsa049660.38663453
83Small cell lung cancer_Homo sapiens_hsa052220.38221310
84One carbon pool by folate_Homo sapiens_hsa006700.36943501
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36893438
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34988259
87Caffeine metabolism_Homo sapiens_hsa002320.34534114
88MAPK signaling pathway_Homo sapiens_hsa040100.34452025
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34339399
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34099318
91Complement and coagulation cascades_Homo sapiens_hsa046100.33958326
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33688737
93Nucleotide excision repair_Homo sapiens_hsa034200.33451394
94Amoebiasis_Homo sapiens_hsa051460.31884935
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31331428
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31088289
97Pentose phosphate pathway_Homo sapiens_hsa000300.29893097
98Arachidonic acid metabolism_Homo sapiens_hsa005900.29663546
99Renal cell carcinoma_Homo sapiens_hsa052110.28035065
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27253954
101Endocytosis_Homo sapiens_hsa041440.27136721
102Ether lipid metabolism_Homo sapiens_hsa005650.26345208
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26151078
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.24730524
105Linoleic acid metabolism_Homo sapiens_hsa005910.23492602
106Spliceosome_Homo sapiens_hsa030400.23276768
107Insulin resistance_Homo sapiens_hsa049310.23105381
108HIF-1 signaling pathway_Homo sapiens_hsa040660.22319039
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.22250152
110Type II diabetes mellitus_Homo sapiens_hsa049300.21852875
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.21222150
112Notch signaling pathway_Homo sapiens_hsa043300.20916600
113Thyroid cancer_Homo sapiens_hsa052160.19636258
114GnRH signaling pathway_Homo sapiens_hsa049120.18870472
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18815440
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18550727
117VEGF signaling pathway_Homo sapiens_hsa043700.18008169
118Choline metabolism in cancer_Homo sapiens_hsa052310.17773314
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16996470
120Pyrimidine metabolism_Homo sapiens_hsa002400.16576376
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15724459
122Protein export_Homo sapiens_hsa030600.15206119
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14998018
124N-Glycan biosynthesis_Homo sapiens_hsa005100.14741389
125Fanconi anemia pathway_Homo sapiens_hsa034600.14225408

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