GPR68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.68105210
2negative T cell selection (GO:0043383)5.64072959
3negative thymic T cell selection (GO:0045060)5.47400222
4cellular response to interleukin-15 (GO:0071350)5.29989766
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21963659
6positive thymic T cell selection (GO:0045059)4.89121900
7positive T cell selection (GO:0043368)4.88714356
8response to interleukin-15 (GO:0070672)4.84910746
9leukocyte aggregation (GO:0070486)4.79128340
10negative regulation of interleukin-12 production (GO:0032695)4.67406491
11T cell migration (GO:0072678)4.66838925
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.66672744
13thymic T cell selection (GO:0045061)4.55527316
14interferon-gamma production (GO:0032609)4.50188023
15positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.43463746
16T cell selection (GO:0045058)4.39009921
17regulation of isotype switching to IgG isotypes (GO:0048302)4.38798230
18response to peptidoglycan (GO:0032494)4.27441083
19lipopolysaccharide-mediated signaling pathway (GO:0031663)4.12931390
20neutrophil activation involved in immune response (GO:0002283)4.09654251
21regulation of mononuclear cell migration (GO:0071675)4.09311216
22positive regulation of alpha-beta T cell proliferation (GO:0046641)4.02490258
23NIK/NF-kappaB signaling (GO:0038061)3.99647825
24regulation of alpha-beta T cell proliferation (GO:0046640)3.98839929
25negative regulation of cell killing (GO:0031342)3.97768968
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.97768968
27positive regulation of humoral immune response (GO:0002922)3.93654926
28macrophage activation involved in immune response (GO:0002281)3.90773619
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.88649460
30regulation of gamma-delta T cell activation (GO:0046643)3.85880794
31positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.84016340
32positive regulation of natural killer cell mediated immunity (GO:0002717)3.84016340
33T-helper 1 type immune response (GO:0042088)3.81794820
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80064741
35regulation of interleukin-2 biosynthetic process (GO:0045076)3.76308974
36regulation of gamma-delta T cell differentiation (GO:0045586)3.68606851
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.68417459
38regulation of natural killer cell mediated immunity (GO:0002715)3.68417459
39regulation of regulatory T cell differentiation (GO:0045589)3.67702772
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.67437171
41positive regulation of interleukin-2 production (GO:0032743)3.66540269
42positive regulation of B cell mediated immunity (GO:0002714)3.61215356
43positive regulation of immunoglobulin mediated immune response (GO:0002891)3.61215356
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.60213571
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.58691883
46T-helper cell differentiation (GO:0042093)3.55336046
47CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.55336046
48regulation of T cell tolerance induction (GO:0002664)3.55006414
49regulation of vitamin D biosynthetic process (GO:0060556)3.54662009
50tolerance induction (GO:0002507)3.50601206
51cellular extravasation (GO:0045123)3.48751196
52regulation of B cell receptor signaling pathway (GO:0050855)3.46548068
53T cell receptor signaling pathway (GO:0050852)3.45943686
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45703417
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45703417
56granulocyte activation (GO:0036230)3.45053692
57natural killer cell activation (GO:0030101)3.44884459
58regulation of T cell receptor signaling pathway (GO:0050856)3.43538401
59T cell costimulation (GO:0031295)3.41344990
60immunoglobulin mediated immune response (GO:0016064)3.41272333
61regulation of leukocyte mediated cytotoxicity (GO:0001910)3.40136361
62lymphocyte costimulation (GO:0031294)3.39295662
63positive regulation of cell killing (GO:0031343)3.38980451
64monocyte chemotaxis (GO:0002548)3.33408112
65positive regulation of chemokine biosynthetic process (GO:0045080)3.31620017
66negative regulation of T cell mediated immunity (GO:0002710)3.31522260
67myeloid dendritic cell activation (GO:0001773)3.29622251
68positive regulation by symbiont of host defense response (GO:0052509)3.27773677
69modulation by symbiont of host defense response (GO:0052031)3.27773677
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27773677
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27773677
72positive regulation by organism of defense response of other organism involved in symbiotic interact3.27773677
73modulation by symbiont of host immune response (GO:0052553)3.27773677
74regulation of cell killing (GO:0031341)3.27261292
75negative regulation of cytokine production involved in immune response (GO:0002719)3.26720921
76antigen processing and presentation of endogenous antigen (GO:0019883)3.26486908
77myeloid dendritic cell differentiation (GO:0043011)3.26041545
78positive regulation of T cell cytokine production (GO:0002726)3.24947574
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24451321
80regulation of immunoglobulin mediated immune response (GO:0002889)3.23249644
81regulation of hypersensitivity (GO:0002883)3.23192377
82positive regulation of isotype switching (GO:0045830)3.23021993
83cellular response to thyroid hormone stimulus (GO:0097067)3.22770941
84alpha-beta T cell differentiation involved in immune response (GO:0002293)3.22360124
85alpha-beta T cell activation involved in immune response (GO:0002287)3.22360124
86T cell differentiation involved in immune response (GO:0002292)3.22360124
87lymphocyte chemotaxis (GO:0048247)3.21010579
88myeloid cell activation involved in immune response (GO:0002275)3.20998613
89positive regulation of interleukin-17 production (GO:0032740)3.20925803
90regulation of mast cell degranulation (GO:0043304)3.20369760
91regulation of podosome assembly (GO:0071801)3.19910813
92positive regulation of DNA recombination (GO:0045911)3.18810343
93regulation of B cell mediated immunity (GO:0002712)3.14001326
94negative regulation of myeloid cell apoptotic process (GO:0033033)3.12748069
95interferon-gamma-mediated signaling pathway (GO:0060333)3.12466734
96regulation of immunoglobulin secretion (GO:0051023)3.11805962
97germinal center formation (GO:0002467)3.10415804
98mast cell activation (GO:0045576)3.09695591
99negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.07619024
100antigen receptor-mediated signaling pathway (GO:0050851)3.07061671
101positive regulation of T cell mediated cytotoxicity (GO:0001916)3.06659703
102neutrophil activation (GO:0042119)3.06613899
103positive regulation of interferon-gamma production (GO:0032729)3.06177430
104glycosphingolipid catabolic process (GO:0046479)3.06171334
105barbed-end actin filament capping (GO:0051016)3.05181688
106positive regulation of lymphocyte mediated immunity (GO:0002708)3.03299354
107activated T cell proliferation (GO:0050798)3.02807313
108regulation of macrophage chemotaxis (GO:0010758)3.01249820
109oligosaccharide catabolic process (GO:0009313)3.01094310
110regulation of interleukin-2 production (GO:0032663)3.01068203
111regulation of isotype switching (GO:0045191)3.00795289
112positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.00777334
113alpha-beta T cell differentiation (GO:0046632)3.00533383
114sequestering of actin monomers (GO:0042989)2.99733521
115alpha-beta T cell activation (GO:0046631)2.99510812
116positive regulation of heat generation (GO:0031652)2.99278529
117amino sugar catabolic process (GO:0046348)2.99137452
118regulation of memory T cell differentiation (GO:0043380)2.97143808
119response to type I interferon (GO:0034340)2.96424347
120response to protozoan (GO:0001562)2.94694016
121T cell activation involved in immune response (GO:0002286)2.94597755
122cellular response to type I interferon (GO:0071357)2.94499404
123type I interferon signaling pathway (GO:0060337)2.94499404
124negative regulation of nitric oxide biosynthetic process (GO:0045019)2.94397948
125positive regulation of mast cell activation (GO:0033005)2.92548151
126regulation of mast cell activation involved in immune response (GO:0033006)2.91847810
127positive regulation of macrophage differentiation (GO:0045651)2.91710816
128response to muramyl dipeptide (GO:0032495)2.91403340
129positive regulation of mast cell degranulation (GO:0043306)2.91054492
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.91054492
131T cell homeostasis (GO:0043029)2.89117224
132lymphocyte migration (GO:0072676)2.88654979
133regulation of chemokine biosynthetic process (GO:0045073)2.88556027
134positive regulation of monocyte chemotaxis (GO:0090026)2.88170883
135regulation of T cell mediated cytotoxicity (GO:0001914)2.87967398
136regulation of lymphocyte chemotaxis (GO:1901623)2.86923215
137defense response to protozoan (GO:0042832)2.86901822
138regulation of chronic inflammatory response (GO:0002676)2.86161793
139regulation of lymphocyte mediated immunity (GO:0002706)2.84253663
140positive regulation of T-helper 1 type immune response (GO:0002827)2.83050165
141leukocyte degranulation (GO:0043299)2.82739320
142CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.81856489
143negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.80126157
144positive regulation of activated T cell proliferation (GO:0042104)2.79991124
145regulation of mast cell activation (GO:0033003)2.79806172
146leukocyte cell-cell adhesion (GO:0007159)2.78075831
147positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.77954173
148positive regulation of leukocyte mediated immunity (GO:0002705)2.77703133
149regulation of leukocyte degranulation (GO:0043300)2.76951065
150negative regulation of innate immune response (GO:0045824)2.73201010
151positive regulation of leukocyte degranulation (GO:0043302)2.73017267
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72930513
153glycolipid catabolic process (GO:0019377)2.72460668
154regulation of fever generation (GO:0031620)2.71847635
155cellular response to lipopolysaccharide (GO:0071222)2.71070339
156regulation of lymphocyte migration (GO:2000401)2.70870134
157neutrophil chemotaxis (GO:0030593)2.69454316
158cellular response to arsenic-containing substance (GO:0071243)2.68984626
159regulation of vitamin metabolic process (GO:0030656)2.68624417
160cellular defense response (GO:0006968)2.67462069
161eosinophil chemotaxis (GO:0048245)2.66871262
162positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66367271
163macrophage chemotaxis (GO:0048246)2.66308777
164tumor necrosis factor-mediated signaling pathway (GO:0033209)2.65436264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.19742610
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.95954689
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.49333330
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.34312764
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.77102177
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76546163
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68686264
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.60390128
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40858494
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99066541
11* IRF8_21731497_ChIP-ChIP_J774_Mouse2.94896075
12* RUNX_20019798_ChIP-Seq_JUKART_Human2.70884619
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.42423428
14VDR_21846776_ChIP-Seq_THP-1_Human2.38474613
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34558768
16VDR_24763502_ChIP-Seq_THP-1_Human2.30770719
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27935816
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23595632
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.17567919
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14044359
21* SPI1_23127762_ChIP-Seq_K562_Human2.09231873
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.05435216
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04472396
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03328899
25GBX2_23144817_ChIP-Seq_PC3_Human1.99400491
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.98688508
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.98336744
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94298725
29MYB_26560356_Chip-Seq_TH2_Human1.93719987
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90254901
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.85115997
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82953619
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81554896
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80253525
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77956480
36SCL_19346495_ChIP-Seq_HPC-7_Human1.74032459
37* LXR_22292898_ChIP-Seq_THP-1_Human1.70345137
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66702009
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63684710
40* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62243644
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60195191
42* MYC_22102868_ChIP-Seq_BL_Human1.56137542
43MAF_26560356_Chip-Seq_TH2_Human1.53995696
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46786881
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46597371
46* TCF7_22412390_ChIP-Seq_EML_Mouse1.46574452
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46261988
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45584469
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43912594
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43882651
51* MYB_26560356_Chip-Seq_TH1_Human1.43060728
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42098859
53KDM2B_26808549_Chip-Seq_DND41_Human1.39902382
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38234991
55* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36940389
56EZH2_22144423_ChIP-Seq_EOC_Human1.33779782
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33583606
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33147157
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33144763
60VDR_24787735_ChIP-Seq_THP-1_Human1.32979369
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31882354
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31384179
63P300_19829295_ChIP-Seq_ESCs_Human1.30632431
64GATA3_27048872_Chip-Seq_THYMUS_Human1.29962601
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29446809
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29273357
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29111196
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.28646984
69* MAF_26560356_Chip-Seq_TH1_Human1.27913365
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26819742
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26684806
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26455489
73IGF1R_20145208_ChIP-Seq_DFB_Human1.25838119
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.23618022
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23616850
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23218355
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22564656
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22487840
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.21750025
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.21252840
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.20426168
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20382783
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19947358
84AR_21572438_ChIP-Seq_LNCaP_Human1.19382953
85BCL6_27268052_Chip-Seq_Bcells_Human1.18351752
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17895488
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.17749824
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.17553047
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.17397114
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16020142
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15240355
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14595070
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14462301
94BCOR_27268052_Chip-Seq_Bcells_Human1.13507041
95GATA1_19941826_ChIP-Seq_K562_Human1.13105749
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12800737
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.12794545
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12551969
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.11622351
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.11206926
101TFEB_21752829_ChIP-Seq_HELA_Human1.10505970
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10278667
103RXR_22108803_ChIP-Seq_LS180_Human1.08734239
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.07640200
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07234483
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04799343
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04714197
108GATA3_26560356_Chip-Seq_TH2_Human1.04379329
109* ER_23166858_ChIP-Seq_MCF-7_Human1.04086817
110P53_22387025_ChIP-Seq_ESCs_Mouse1.03943573
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03720682
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03478710
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03387965
114TAF15_26573619_Chip-Seq_HEK293_Human1.03360174
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02968309
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02599032
117GATA1_22025678_ChIP-Seq_K562_Human1.02398429
118SMAD4_21799915_ChIP-Seq_A2780_Human1.01722411
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01030573
120P300_18555785_Chip-Seq_ESCs_Mouse1.00405923
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.00399496
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99716683
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99173919
124PU1_27457419_Chip-Seq_LIVER_Mouse0.98334630
125SPI1_23547873_ChIP-Seq_NB4_Human0.97555623
126VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97249492
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97193829
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.96265447
129ZFX_18555785_Chip-Seq_ESCs_Mouse0.94374221
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93695150
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93695150
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93571456
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92477039
134PU_27001747_Chip-Seq_BMDM_Mouse0.92023505
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.91723526
136MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91261301
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90979571
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90616282
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90553627
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90533181
141ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89992546
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89660304
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89408190
144TP53_18474530_ChIP-ChIP_U2OS_Human0.88862354
145KLF4_18555785_Chip-Seq_ESCs_Mouse0.88187569
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87853021
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87037332
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86956177
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86105543
150* UTX_26944678_Chip-Seq_JUKART_Human0.85718643
151CTCF_18555785_Chip-Seq_ESCs_Mouse0.85122206
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85106516
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84699680
154SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83707070
155STAT1_20625510_ChIP-Seq_HELA_Human0.83471451
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83329028
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82769393
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82463575
159SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81282941
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80387728
161AR_25329375_ChIP-Seq_VCAP_Human0.79755900
162RNF2_27304074_Chip-Seq_NSC_Mouse0.79128497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.62726137
2MP0001835_abnormal_antigen_presentation3.75925702
3MP0003763_abnormal_thymus_physiology3.66561263
4MP0005058_abnormal_lysosome_morphology3.43979971
5MP0000685_abnormal_immune_system3.28989819
6MP0009785_altered_susceptibility_to3.24042053
7MP0005387_immune_system_phenotype3.07139951
8MP0001790_abnormal_immune_system3.07139951
9MP0009840_abnormal_foam_cell3.05799062
10MP0005000_abnormal_immune_tolerance2.75085370
11MP0001800_abnormal_humoral_immune2.65352385
12MP0002148_abnormal_hypersensitivity_rea2.55618037
13MP0002723_abnormal_immune_serum2.49923721
14MP0005025_abnormal_response_to2.46734170
15MP0006082_CNS_inflammation2.45089656
16MP0002166_altered_tumor_susceptibility2.43524535
17MP0003724_increased_susceptibility_to2.42948633
18* MP0002420_abnormal_adaptive_immunity2.40086025
19* MP0001819_abnormal_immune_cell2.39536773
20MP0002006_tumorigenesis2.38771537
21* MP0002452_abnormal_antigen_presenting2.26785025
22MP0003172_abnormal_lysosome_physiology2.25730639
23MP0003436_decreased_susceptibility_to2.23727596
24MP0000343_altered_response_to2.15044092
25MP0009278_abnormal_bone_marrow2.07364661
26MP0003191_abnormal_cellular_cholesterol2.03471366
27MP0004381_abnormal_hair_follicle2.02741150
28* MP0002419_abnormal_innate_immunity2.01251121
29MP0004510_myositis1.99107260
30MP0002405_respiratory_system_inflammati1.99100679
31MP0002009_preneoplasia1.95372036
32MP0002398_abnormal_bone_marrow1.95087039
33MP0001873_stomach_inflammation1.92630881
34MP0003075_altered_response_to1.91347332
35MP0009333_abnormal_splenocyte_physiolog1.86810382
36MP0003787_abnormal_imprinting1.85754343
37* MP0000716_abnormal_immune_system1.85490846
38MP0000604_amyloidosis1.85172093
39MP0002933_joint_inflammation1.79115648
40MP0003880_abnormal_central_pattern1.75427385
41MP0004947_skin_inflammation1.74728866
42MP0005310_abnormal_salivary_gland1.71516001
43MP0010155_abnormal_intestine_physiology1.67684222
44MP0005645_abnormal_hypothalamus_physiol1.67238351
45MP0002138_abnormal_hepatobiliary_system1.59601468
46MP0000703_abnormal_thymus_morphology1.53760330
47MP0003866_abnormal_defecation1.52269814
48MP0002139_abnormal_hepatobiliary_system1.51336279
49MP0005167_abnormal_blood-brain_barrier1.49677605
50MP0002722_abnormal_immune_system1.46666221
51MP0002163_abnormal_gland_morphology1.44365248
52MP0000015_abnormal_ear_pigmentation1.43390274
53MP0002277_abnormal_respiratory_mucosa1.40088171
54MP0003690_abnormal_glial_cell1.38511498
55MP0001845_abnormal_inflammatory_respons1.37427839
56MP0005451_abnormal_body_composition1.37408496
57MP0000689_abnormal_spleen_morphology1.37238524
58MP0001853_heart_inflammation1.36982356
59MP0005397_hematopoietic_system_phenotyp1.34856633
60MP0001545_abnormal_hematopoietic_system1.34856633
61* MP0002429_abnormal_blood_cell1.33576519
62MP0006054_spinal_hemorrhage1.29645173
63MP0005166_decreased_susceptibility_to1.24850721
64MP0002822_catalepsy1.21828180
65MP0009764_decreased_sensitivity_to1.16278656
66MP0005464_abnormal_platelet_physiology1.15880723
67MP0003656_abnormal_erythrocyte_physiolo1.12547075
68MP0006292_abnormal_olfactory_placode1.12228438
69MP0001501_abnormal_sleep_pattern1.11984919
70* MP0003448_altered_tumor_morphology1.11702821
71MP0003806_abnormal_nucleotide_metabolis1.10995919
72MP0001986_abnormal_taste_sensitivity1.09804601
73MP0002877_abnormal_melanocyte_morpholog1.08904329
74MP0005390_skeleton_phenotype1.08830028
75MP0003828_pulmonary_edema1.08370228
76MP0002132_abnormal_respiratory_system1.08316910
77MP0000920_abnormal_myelination1.08088195
78MP0000465_gastrointestinal_hemorrhage1.07207532
79MP0001188_hyperpigmentation1.04893020
80MP0005646_abnormal_pituitary_gland1.04427274
81MP0005423_abnormal_somatic_nervous1.03476301
82MP0002396_abnormal_hematopoietic_system1.02816575
83MP0004742_abnormal_vestibular_system1.02785361
84MP0003300_gastrointestinal_ulcer1.02598025
85MP0003183_abnormal_peptide_metabolism1.01497718
86MP0010386_abnormal_urinary_bladder1.00937661
87MP0003136_yellow_coat_color1.00136825
88MP0001851_eye_inflammation0.99792477
89MP0001348_abnormal_lacrimal_gland0.98950551
90* MP0002998_abnormal_bone_remodeling0.98844973
91MP0005164_abnormal_response_to0.98754105
92MP0005174_abnormal_tail_pigmentation0.97990841
93MP0001533_abnormal_skeleton_physiology0.97678216
94MP0000858_altered_metastatic_potential0.97049335
95MP0005171_absent_coat_pigmentation0.96319843
96MP0000372_irregular_coat_pigmentation0.96209215
97MP0009763_increased_sensitivity_to0.96020668
98MP0003303_peritoneal_inflammation0.94216638
99MP0003329_amyloid_beta_deposits0.93203022
100MP0002254_reproductive_system_inflammat0.89955265
101MP0002735_abnormal_chemical_nociception0.89813047
102MP0001502_abnormal_circadian_rhythm0.88943652
103MP0001542_abnormal_bone_strength0.88313482
104MP0005075_abnormal_melanosome_morpholog0.87761687
105MP0008469_abnormal_protein_level0.87523534
106MP0002837_dystrophic_cardiac_calcinosis0.87380993
107* MP0003795_abnormal_bone_structure0.87001022
108MP0005023_abnormal_wound_healing0.86869615
109MP0008260_abnormal_autophagy0.84744446
110MP0009765_abnormal_xenobiotic_induced0.83763161
111MP0002876_abnormal_thyroid_physiology0.82814169
112MP0002736_abnormal_nociception_after0.82234885
113MP0008004_abnormal_stomach_pH0.80982420
114MP0009046_muscle_twitch0.80919438
115MP0003279_aneurysm0.80536141
116MP0005379_endocrine/exocrine_gland_phen0.79977645
117MP0009745_abnormal_behavioral_response0.79616580
118MP0001346_abnormal_lacrimal_gland0.78729513
119MP0005165_increased_susceptibility_to0.77655637
120MP0000249_abnormal_blood_vessel0.76797828
121MP0002095_abnormal_skin_pigmentation0.75367877
122MP0001663_abnormal_digestive_system0.75262602
123MP0003045_fibrosis0.71326153
124MP0003091_abnormal_cell_migration0.71039080
125MP0004883_abnormal_blood_vessel0.70530382
126MP0000371_diluted_coat_color0.69657778
127MP0002332_abnormal_exercise_endurance0.68466847
128MP0002638_abnormal_pupillary_reflex0.68352361
129MP0001968_abnormal_touch/_nociception0.66755261
130MP0004782_abnormal_surfactant_physiolog0.65221936
131MP0008874_decreased_physiological_sensi0.64398100
132MP0002102_abnormal_ear_morphology0.62705263
133MP0008569_lethality_at_weaning0.62185926
134MP0003453_abnormal_keratinocyte_physiol0.61019085
135MP0005595_abnormal_vascular_smooth0.60803553
136MP0001529_abnormal_vocalization0.60740077
137MP0002064_seizures0.60317979
138MP0006276_abnormal_autonomic_nervous0.57587359
139MP0000569_abnormal_digit_pigmentation0.57408409
140MP0001984_abnormal_olfaction0.56409639
141MP0005409_darkened_coat_color0.56282077
142MP0000490_abnormal_crypts_of0.55885898
143MP0002572_abnormal_emotion/affect_behav0.55231060
144MP0003634_abnormal_glial_cell0.55051735
145MP0000609_abnormal_liver_physiology0.54229319
146MP0003879_abnormal_hair_cell0.52502908
147MP0003195_calcinosis0.49544669
148MP0001216_abnormal_epidermal_layer0.47341674

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.32947839
2Abnormality of liposaccharide metabolism (HP:0010968)6.32947839
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.32947839
4Stomatitis (HP:0010280)5.08281824
5Vacuolated lymphocytes (HP:0001922)5.00358111
6Optic neuritis (HP:0100653)4.98726106
7Retrobulbar optic neuritis (HP:0100654)4.98726106
8Dysostosis multiplex (HP:0000943)4.74799952
9Abnormality of T cell number (HP:0011839)4.69638612
10Chronic mucocutaneous candidiasis (HP:0002728)4.55171681
11Recurrent cutaneous fungal infections (HP:0011370)4.55171681
12Elevated erythrocyte sedimentation rate (HP:0003565)4.51814386
13T lymphocytopenia (HP:0005403)4.47075185
14Recurrent fungal infections (HP:0002841)4.37919919
15Eczematoid dermatitis (HP:0000976)4.37309579
16Increased cerebral lipofuscin (HP:0011813)4.29399591
17Severe combined immunodeficiency (HP:0004430)4.28679212
18Myositis (HP:0100614)4.27120726
19Recurrent abscess formation (HP:0002722)4.07200000
20Increased IgM level (HP:0003496)4.04678039
21Loss of speech (HP:0002371)4.04461876
22Orchitis (HP:0100796)3.96361077
23Systemic lupus erythematosus (HP:0002725)3.82628596
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.65573778
25Chronic diarrhea (HP:0002028)3.65352176
26Combined immunodeficiency (HP:0005387)3.55250725
27Disinhibition (HP:0000734)3.44158823
28Mediastinal lymphadenopathy (HP:0100721)3.42345709
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.37283592
30Abnormality of polysaccharide metabolism (HP:0011012)3.37283592
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.37283592
32Neurofibrillary tangles (HP:0002185)3.26924663
33Mutism (HP:0002300)3.25974217
34Mucopolysacchariduria (HP:0008155)3.20230152
35Urinary glycosaminoglycan excretion (HP:0003541)3.20230152
36Chronic otitis media (HP:0000389)3.19515985
37Abnormality of T cells (HP:0002843)3.19431971
38Pustule (HP:0200039)3.16707608
39Recurrent bronchitis (HP:0002837)3.12601846
40IgG deficiency (HP:0004315)3.08649250
41Abnormality of eosinophils (HP:0001879)3.08267896
42Vasculitis (HP:0002633)3.07086080
43Cheilitis (HP:0100825)3.05385886
44Abnormal delayed hypersensitivity skin test (HP:0002963)3.04007115
45Panhypogammaglobulinemia (HP:0003139)3.00953388
46Pulmonary infiltrates (HP:0002113)2.98328079
47Recurrent viral infections (HP:0004429)2.96599730
48Thyroiditis (HP:0100646)2.96556477
49Lymphopenia (HP:0001888)2.95224980
50Hemoptysis (HP:0002105)2.93694824
51Axonal loss (HP:0003447)2.92953714
52Recurrent bacterial skin infections (HP:0005406)2.92412388
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.90925927
54Recurrent skin infections (HP:0001581)2.90187001
55Autoimmune hemolytic anemia (HP:0001890)2.89582556
56Chronic obstructive pulmonary disease (HP:0006510)2.88867745
57Obstructive lung disease (HP:0006536)2.88867745
58Leukocytosis (HP:0001974)2.84995413
59Increased IgE level (HP:0003212)2.82224981
60Amyloidosis (HP:0011034)2.80490808
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.80252780
62Keratoconjunctivitis sicca (HP:0001097)2.74398741
63Increased serum ferritin (HP:0003281)2.72846421
64Abnormality of DNA repair (HP:0003254)2.72783076
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72647001
66Abnormal hair whorl (HP:0010721)2.66058137
67Eosinophilia (HP:0001880)2.65241118
68Hypergammaglobulinemia (HP:0010702)2.64960629
69Meningitis (HP:0001287)2.64528634
70Abnormality of the vasculature of the conjunctiva (HP:0008054)2.62404368
71Keratoconjunctivitis (HP:0001096)2.62033781
72Gingivitis (HP:0000230)2.59990928
73Febrile seizures (HP:0002373)2.57963830
74Joint swelling (HP:0001386)2.56531756
75Nuclear cataract (HP:0100018)2.53813940
76Spontaneous hematomas (HP:0007420)2.52844763
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50485652
78Hematochezia (HP:0002573)2.46626285
79Hepatosplenomegaly (HP:0001433)2.44902272
80Chromsome breakage (HP:0040012)2.41374984
81Petechiae (HP:0000967)2.40926263
82B lymphocytopenia (HP:0010976)2.39439808
83Abnormality of B cell number (HP:0010975)2.39439808
84Abnormality of the nasal mucosa (HP:0000433)2.39294258
85Glomerulonephritis (HP:0000099)2.36816781
86Neuronal loss in central nervous system (HP:0002529)2.35412697
87Purpura (HP:0000979)2.34641782
88Arterial thrombosis (HP:0004420)2.34393960
89Keratitis (HP:0000491)2.34082732
90IgM deficiency (HP:0002850)2.33090168
91Granulocytopenia (HP:0001913)2.33050011
92Cerebral inclusion bodies (HP:0100314)2.32388699
93Abnormality of macrophages (HP:0004311)2.29100858
94Urticaria (HP:0001025)2.28150708
95Progressive neurologic deterioration (HP:0002344)2.27511878
96Nasal polyposis (HP:0100582)2.27401215
97Encephalitis (HP:0002383)2.26553971
98Chronic sinusitis (HP:0011109)2.26537787
99Agammaglobulinemia (HP:0004432)2.25885814
100Gastrointestinal infarctions (HP:0005244)2.24674625
101Metaphyseal irregularity (HP:0003025)2.22439574
102Recurrent gram-negative bacterial infections (HP:0005420)2.21602989
103Supranuclear gaze palsy (HP:0000605)2.20930605
104Spondylolisthesis (HP:0003302)2.19400016
105Abnormality of the fingertips (HP:0001211)2.18282141
106Polyneuropathy (HP:0001271)2.17547288
107Diminished motivation (HP:0000745)2.16463566
108Apathy (HP:0000741)2.15120934
109Myocardial infarction (HP:0001658)2.12751202
110Gastrointestinal stroma tumor (HP:0100723)2.12743069
111Vertebral compression fractures (HP:0002953)2.10307026
112Hypoplasia of the thymus (HP:0000778)2.09475916
113Abnormality of the prostate (HP:0008775)2.08677095
114Upper motor neuron abnormality (HP:0002127)2.08424340
115Prostate neoplasm (HP:0100787)2.07754546
116Gangrene (HP:0100758)2.07635448
117Abnormality of iron homeostasis (HP:0011031)2.07350835
118Hypoproteinemia (HP:0003075)2.06025202
119Restrictive lung disease (HP:0002091)2.04229876
120Prolonged neonatal jaundice (HP:0006579)2.03988212
121Premature loss of primary teeth (HP:0006323)2.02696119
122Abnormality of T cell physiology (HP:0011840)2.02315382
123Autoimmune thrombocytopenia (HP:0001973)2.01698307
124Recurrent sinusitis (HP:0011108)2.00610058
125Agnosia (HP:0010524)1.97677391
126Clubbing of toes (HP:0100760)1.97162541
127Interstitial pulmonary disease (HP:0006530)1.96172352
128Parakeratosis (HP:0001036)1.96124991
129Flat occiput (HP:0005469)1.94938606
130Abnormality of the endocardium (HP:0004306)1.90822107
131Arthralgia (HP:0002829)1.90125910
132Ectropion (HP:0000656)1.88419352
133Basal ganglia calcification (HP:0002135)1.88115554
134Recurrent pneumonia (HP:0006532)1.87539927
135Anorexia (HP:0002039)1.84980578
136Personality changes (HP:0000751)1.84058188
137Abnormality of incisor morphology (HP:0011063)1.81307692
138Anhidrosis (HP:0000970)1.79919749
139Lymphoma (HP:0002665)1.79824751
140Stomach cancer (HP:0012126)1.79455843
141Bronchitis (HP:0012387)1.79305967
142Abnormality of the renal collecting system (HP:0004742)1.78397083
143Duplicated collecting system (HP:0000081)1.77596170
144Conical tooth (HP:0000698)1.76967388
145Bronchiectasis (HP:0002110)1.76623035
146Focal motor seizures (HP:0011153)1.73581882
147Hypothermia (HP:0002045)1.73421241
148Periodontitis (HP:0000704)1.72143508
149Glomerulopathy (HP:0100820)1.71082217
150Inflammation of the large intestine (HP:0002037)1.69948585
151Recurrent otitis media (HP:0000403)1.69193964
152Ectopic kidney (HP:0000086)1.68647768
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.68596490
154Absent/shortened dynein arms (HP:0200106)1.68596490
155Abnormality of male internal genitalia (HP:0000022)1.65539872
156IgA deficiency (HP:0002720)1.64785166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.31879725
2MAP3K144.18533275
3IKBKE3.67580084
4MAP4K13.02595661
5JAK32.93704145
6TBK12.77175679
7CASK2.57141944
8ERN12.55832940
9SIK32.43416567
10TNIK2.37336690
11TYK22.33767960
12TGFBR22.25745571
13IRAK42.16972811
14FGR2.16225675
15PRPF4B2.09468175
16MATK2.05629431
17IKBKB2.03467718
18MAP3K111.98548901
19ITK1.94938733
20DDR21.91467527
21JAK11.88253793
22TESK21.87923160
23ZAP701.86353449
24MAP3K131.84728951
25MAP3K121.72332513
26TEC1.70897161
27FGFR31.60281364
28CAMKK21.57624433
29MST41.56908300
30LCK1.56680967
31TESK11.50557614
32MAP3K31.48951857
33MAP2K31.46972763
34NLK1.44107364
35ADRBK21.38466839
36FGFR41.35034091
37KIT1.34900069
38CHUK1.34898478
39TAOK21.34071185
40MAP2K71.31984304
41BMPR21.23042740
42SYK1.21711077
43MOS1.21198191
44IRAK31.17924288
45HCK1.17063749
46CDC42BPA1.16196575
47CSF1R1.08017207
48RIPK41.07358061
49NTRK21.04004474
50CAMKK11.00052635
51PRKCQ0.99831506
52SGK20.99152357
53PRKCH0.97502317
54GRK70.96164091
55BLK0.95511294
56SIK20.95472241
57LIMK10.94006563
58BTK0.92124971
59IRAK10.92093786
60TNK20.92031810
61MKNK20.90167124
62ABL20.89783472
63YES10.86892754
64MUSK0.86638386
65CSK0.85830061
66MAP3K10.83871910
67ACVR1B0.82385419
68FES0.80053248
69LYN0.78739568
70NEK60.77744154
71CDK90.76540738
72STK100.76241799
73MAPK130.76223561
74BCR0.75717254
75EPHB10.75437522
76RIPK10.71093465
77PKN10.70494773
78BMPR1B0.70427835
79EPHA30.68555540
80ARAF0.67174042
81MAPK70.66845778
82SGK30.66610330
83CLK10.66584408
84ZAK0.65895305
85MAP2K60.65286749
86MAP2K20.63846200
87CAMK1D0.62964601
88PIM10.61719713
89IRAK20.60504665
90TYRO30.58226748
91PIM20.56859828
92MAP3K50.56188771
93NME20.53525403
94KDR0.53444426
95CDK30.52819985
96JAK20.51063424
97PDK10.50749989
98AKT30.50090012
99GRK60.50039124
100MARK30.49202959
101NUAK10.48878135
102TRPM70.48234765
103RPS6KC10.48043069
104RPS6KL10.48043069
105PDPK10.46461776
106EIF2AK20.43950574
107SIK10.43430722
108MAPK40.42694688
109SGK2230.42655910
110SGK4940.42655910
111RPS6KA20.42456365
112NEK90.42041523
113SGK10.41957355
114HIPK20.41781871
115MAP3K60.41548551
116CDK80.40914642
117STK160.40744507
118IGF1R0.40742738
119PDGFRA0.40508323
120PRKCD0.39995552
121RPS6KA60.38158261
122MARK20.38148821
123STK240.38130908
124MAPKAPK20.37700846
125NTRK30.37676662
126TTN0.35936361
127TAOK30.33089300
128PAK40.32932071
129MAP3K70.31923482
130MAPK30.31188110
131PRKCE0.30625217
132PRKD20.29833346
133FYN0.29552642
134TAOK10.29138462
135PDGFRB0.28962961
136CDK60.28721263
137MAPK120.27741641
138ABL10.27330781
139CDK40.27301902
140TGFBR10.26237436
141EPHA40.24678182
142BRD40.23904127
143SRPK10.23634536
144TLK10.22819695
145INSR0.21705804

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.78182145
2Graft-versus-host disease_Homo sapiens_hsa053323.41033866
3Allograft rejection_Homo sapiens_hsa053303.29635188
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.13962660
5Lysosome_Homo sapiens_hsa041422.71079324
6Autoimmune thyroid disease_Homo sapiens_hsa053202.64162577
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.62174644
8Measles_Homo sapiens_hsa051622.59880583
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.48169811
10T cell receptor signaling pathway_Homo sapiens_hsa046602.44915978
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36664229
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22496843
13Type I diabetes mellitus_Homo sapiens_hsa049402.09585993
14Hematopoietic cell lineage_Homo sapiens_hsa046402.07737403
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05749704
16Asthma_Homo sapiens_hsa053101.97569516
17Leishmaniasis_Homo sapiens_hsa051401.95398808
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.84660156
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70035472
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.67843502
21Rheumatoid arthritis_Homo sapiens_hsa053231.66672183
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62580110
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61941238
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57647966
25Osteoclast differentiation_Homo sapiens_hsa043801.57255936
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45267679
27Antigen processing and presentation_Homo sapiens_hsa046121.41419729
28TNF signaling pathway_Homo sapiens_hsa046681.38775789
29Chemokine signaling pathway_Homo sapiens_hsa040621.38754793
30Nicotine addiction_Homo sapiens_hsa050331.29042507
31Herpes simplex infection_Homo sapiens_hsa051681.26694282
32Influenza A_Homo sapiens_hsa051641.22700233
33Malaria_Homo sapiens_hsa051441.21720820
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14496358
35Tuberculosis_Homo sapiens_hsa051521.13843891
36Hepatitis B_Homo sapiens_hsa051611.09001047
37Toxoplasmosis_Homo sapiens_hsa051451.04730760
38B cell receptor signaling pathway_Homo sapiens_hsa046621.00875615
39African trypanosomiasis_Homo sapiens_hsa051430.98781650
40Prion diseases_Homo sapiens_hsa050200.98592750
41Viral myocarditis_Homo sapiens_hsa054160.98587308
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97589509
43Bladder cancer_Homo sapiens_hsa052190.94596483
44Apoptosis_Homo sapiens_hsa042100.93971494
45Legionellosis_Homo sapiens_hsa051340.93102092
46Collecting duct acid secretion_Homo sapiens_hsa049660.89634828
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88502159
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88491521
49Hepatitis C_Homo sapiens_hsa051600.85539471
50Shigellosis_Homo sapiens_hsa051310.82957005
51Pertussis_Homo sapiens_hsa051330.82681063
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81702577
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80341701
54Morphine addiction_Homo sapiens_hsa050320.77757881
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77384131
56Prolactin signaling pathway_Homo sapiens_hsa049170.77365448
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77250145
58Mineral absorption_Homo sapiens_hsa049780.76588866
59VEGF signaling pathway_Homo sapiens_hsa043700.75680077
60Other glycan degradation_Homo sapiens_hsa005110.75007687
61Amoebiasis_Homo sapiens_hsa051460.72697648
62Salmonella infection_Homo sapiens_hsa051320.70050781
63Acute myeloid leukemia_Homo sapiens_hsa052210.69868267
64HTLV-I infection_Homo sapiens_hsa051660.69496805
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.68372053
66Vibrio cholerae infection_Homo sapiens_hsa051100.65324572
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.65297888
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65167258
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63218135
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62258258
71Epstein-Barr virus infection_Homo sapiens_hsa051690.59734074
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59555011
73Complement and coagulation cascades_Homo sapiens_hsa046100.59142481
74Pancreatic cancer_Homo sapiens_hsa052120.59048948
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.58708301
76Endocytosis_Homo sapiens_hsa041440.56879623
77Sphingolipid metabolism_Homo sapiens_hsa006000.55919728
78Chronic myeloid leukemia_Homo sapiens_hsa052200.53442571
79Glutamatergic synapse_Homo sapiens_hsa047240.52689406
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52519219
81MAPK signaling pathway_Homo sapiens_hsa040100.51597135
82Taste transduction_Homo sapiens_hsa047420.51354269
83Phagosome_Homo sapiens_hsa041450.50882471
84Olfactory transduction_Homo sapiens_hsa047400.50158079
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49459227
86Staphylococcus aureus infection_Homo sapiens_hsa051500.49386108
87Serotonergic synapse_Homo sapiens_hsa047260.48904750
88Synaptic vesicle cycle_Homo sapiens_hsa047210.44810381
89Inositol phosphate metabolism_Homo sapiens_hsa005620.43535368
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43493576
91Circadian rhythm_Homo sapiens_hsa047100.42150000
92Fanconi anemia pathway_Homo sapiens_hsa034600.41839951
93Sulfur metabolism_Homo sapiens_hsa009200.38800752
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38472784
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38392445
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37286395
97p53 signaling pathway_Homo sapiens_hsa041150.36806995
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.36629710
99Circadian entrainment_Homo sapiens_hsa047130.36603836
100Ras signaling pathway_Homo sapiens_hsa040140.36587740
101GnRH signaling pathway_Homo sapiens_hsa049120.36319327
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36165751
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.34947892
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34892183
105Cholinergic synapse_Homo sapiens_hsa047250.34097040
106Choline metabolism in cancer_Homo sapiens_hsa052310.33875282
107cAMP signaling pathway_Homo sapiens_hsa040240.32658175
108Viral carcinogenesis_Homo sapiens_hsa052030.32070858
109GABAergic synapse_Homo sapiens_hsa047270.30978325
110Calcium signaling pathway_Homo sapiens_hsa040200.30918314
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30681796
112Non-small cell lung cancer_Homo sapiens_hsa052230.30578577
113Renal cell carcinoma_Homo sapiens_hsa052110.30494532
114Type II diabetes mellitus_Homo sapiens_hsa049300.30484716
115Ether lipid metabolism_Homo sapiens_hsa005650.30289064
116HIF-1 signaling pathway_Homo sapiens_hsa040660.30084801
117Colorectal cancer_Homo sapiens_hsa052100.29376197
118Rap1 signaling pathway_Homo sapiens_hsa040150.27744170
119Platelet activation_Homo sapiens_hsa046110.27102400
120ErbB signaling pathway_Homo sapiens_hsa040120.27042415
121Salivary secretion_Homo sapiens_hsa049700.26921807
122RNA degradation_Homo sapiens_hsa030180.25037300
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24760542
124Notch signaling pathway_Homo sapiens_hsa043300.23892744
125Galactose metabolism_Homo sapiens_hsa000520.22790192
126Insulin resistance_Homo sapiens_hsa049310.21365448
127Renin-angiotensin system_Homo sapiens_hsa046140.18190568
128Proteoglycans in cancer_Homo sapiens_hsa052050.16441651
129Fructose and mannose metabolism_Homo sapiens_hsa000510.15847253
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14227626

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