GPR75

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85880123
2synaptic vesicle exocytosis (GO:0016079)5.35029307
3glutamate secretion (GO:0014047)4.99071924
4locomotory exploration behavior (GO:0035641)4.96314091
5neuron cell-cell adhesion (GO:0007158)4.96284684
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87194044
7regulation of synaptic vesicle exocytosis (GO:2000300)4.82991078
8vocalization behavior (GO:0071625)4.80100382
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78700379
10synaptic vesicle maturation (GO:0016188)4.78382636
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.73964085
12astrocyte differentiation (GO:0048708)4.62000685
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60605920
14neuronal action potential propagation (GO:0019227)4.56163908
15synaptic transmission, glutamatergic (GO:0035249)4.55999322
16regulation of histone H3-K27 methylation (GO:0061085)4.47157639
17neuron-neuron synaptic transmission (GO:0007270)4.37929435
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.36058116
19neurotransmitter secretion (GO:0007269)4.32350762
20glutamate receptor signaling pathway (GO:0007215)4.30827419
21protein localization to synapse (GO:0035418)4.29939872
22regulation of glutamate receptor signaling pathway (GO:1900449)4.28893106
23regulation of synaptic vesicle transport (GO:1902803)4.21216051
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.13259675
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09472902
26neurotransmitter-gated ion channel clustering (GO:0072578)4.04665960
27positive regulation of p38MAPK cascade (GO:1900745)4.03735455
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98706311
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.97432231
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96079447
31L-amino acid import (GO:0043092)3.93409257
32regulation of RNA export from nucleus (GO:0046831)3.93062301
33regulation of ARF protein signal transduction (GO:0032012)3.92102117
34exploration behavior (GO:0035640)3.86690788
35gamma-aminobutyric acid transport (GO:0015812)3.85152993
36macroautophagy (GO:0016236)3.83856910
37regulation of neuronal synaptic plasticity (GO:0048168)3.76410767
38presynaptic membrane assembly (GO:0097105)3.75862457
39transmission of nerve impulse (GO:0019226)3.74236702
40amino acid import (GO:0043090)3.71746017
41long-term synaptic potentiation (GO:0060291)3.71187047
42regulation of nucleobase-containing compound transport (GO:0032239)3.67111357
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64461476
44neuromuscular process controlling posture (GO:0050884)3.61810514
45embryonic camera-type eye morphogenesis (GO:0048596)3.61609213
46neurotransmitter transport (GO:0006836)3.58645882
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56302006
48neuron recognition (GO:0008038)3.55861761
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.54915548
50presynaptic membrane organization (GO:0097090)3.54045709
51long-term memory (GO:0007616)3.53332281
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51807648
53positive regulation of synapse maturation (GO:0090129)3.50722664
54regulation of p38MAPK cascade (GO:1900744)3.50413746
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49680722
56regulation of postsynaptic membrane potential (GO:0060078)3.49117802
57regulation of protein glycosylation (GO:0060049)3.48620959
58response to histamine (GO:0034776)3.48535632
59cerebellar granule cell differentiation (GO:0021707)3.47918442
60cerebellar Purkinje cell differentiation (GO:0021702)3.46255243
61postsynaptic membrane organization (GO:0001941)3.46204391
62nuclear pore complex assembly (GO:0051292)3.45613420
63embryonic retina morphogenesis in camera-type eye (GO:0060059)3.42159128
64membrane depolarization during action potential (GO:0086010)3.40344613
65cellular potassium ion homeostasis (GO:0030007)3.39674994
66regulation of neurotransmitter levels (GO:0001505)3.39375442
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36698281
68regulation of synaptic plasticity (GO:0048167)3.34474725
69positive regulation of gluconeogenesis (GO:0045722)3.34350575
70proline transport (GO:0015824)3.32983540
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.31379252
72potassium ion import (GO:0010107)3.28246293
73axonal fasciculation (GO:0007413)3.27872074
74potassium ion homeostasis (GO:0055075)3.26112092
75membrane hyperpolarization (GO:0060081)3.25965017
76regulation of synapse structural plasticity (GO:0051823)3.25319706
77regulation of neurotransmitter secretion (GO:0046928)3.24235803
78positive regulation of membrane potential (GO:0045838)3.23719803
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22311075
80striatum development (GO:0021756)3.20426609
81auditory behavior (GO:0031223)3.19394227
82response to auditory stimulus (GO:0010996)3.19343250
83membrane depolarization (GO:0051899)3.17497473
84regulation of vesicle fusion (GO:0031338)3.17307001
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17256617
86regulation of clathrin-mediated endocytosis (GO:2000369)3.16862649
87negative regulation of neurotransmitter secretion (GO:0046929)3.16860787
88startle response (GO:0001964)3.15278070
89dendritic spine morphogenesis (GO:0060997)3.13831889
90nuclear pore organization (GO:0006999)3.12148825
91synaptic vesicle endocytosis (GO:0048488)3.12061532
92positive regulation of synapse assembly (GO:0051965)3.11709668
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10862908
94positive regulation of macroautophagy (GO:0016239)3.10001669
95negative regulation of dendrite morphogenesis (GO:0050774)3.07282535
96activation of protein kinase A activity (GO:0034199)3.06492588
97regulation of neurotransmitter transport (GO:0051588)3.05806584
98mechanosensory behavior (GO:0007638)3.04322900
99synaptic transmission (GO:0007268)3.03841892
100regulation of synaptic transmission, GABAergic (GO:0032228)3.03705401
101positive regulation of synaptic transmission (GO:0050806)3.01462124
102phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.00432230
103negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00061856
104synapse assembly (GO:0007416)2.99269814
105embryonic process involved in female pregnancy (GO:0060136)2.99263189
106learning (GO:0007612)2.97797090
107behavioral response to cocaine (GO:0048148)2.97686317
108regulation of voltage-gated calcium channel activity (GO:1901385)2.97628596
109regulation of synapse maturation (GO:0090128)2.97572373
110innervation (GO:0060384)2.96530570
111regulation of NFAT protein import into nucleus (GO:0051532)2.95525424
112adult walking behavior (GO:0007628)2.95149972
113behavioral fear response (GO:0001662)2.95080299
114behavioral defense response (GO:0002209)2.95080299
115prepulse inhibition (GO:0060134)2.94312894
116mating behavior (GO:0007617)2.93855251
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.93781772
118regulation of synaptic transmission (GO:0050804)2.91974991
119response to pheromone (GO:0019236)2.91610832
120regulation of dendritic spine morphogenesis (GO:0061001)2.90167326
121cell communication by electrical coupling (GO:0010644)2.90030447
122sodium ion export (GO:0071436)2.89750694
123layer formation in cerebral cortex (GO:0021819)2.87146038
124beta-amyloid metabolic process (GO:0050435)2.86586468
125long term synaptic depression (GO:0060292)2.85465674
126regulation of protein kinase A signaling (GO:0010738)2.85396379
127regulation of energy homeostasis (GO:2000505)2.83073401
128histone H3-K4 trimethylation (GO:0080182)2.82538118
129chemosensory behavior (GO:0007635)2.82048544
130negative regulation of smooth muscle cell differentiation (GO:0051151)2.78617858
131central nervous system myelination (GO:0022010)2.74755996
132axon ensheathment in central nervous system (GO:0032291)2.74755996
133righting reflex (GO:0060013)2.71872922
134embryonic eye morphogenesis (GO:0048048)2.69048813
135response to methylmercury (GO:0051597)2.66667002
136positive regulation of DNA-templated transcription, initiation (GO:2000144)2.66425412
137peptidyl-lysine trimethylation (GO:0018023)2.66097866
138peptidyl-threonine phosphorylation (GO:0018107)2.62468213
139embryonic foregut morphogenesis (GO:0048617)2.60989758
140dicarboxylic acid biosynthetic process (GO:0043650)2.60062743
141cellular response to ethanol (GO:0071361)2.56124830
142pore complex assembly (GO:0046931)2.51943544
143regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.51439183
144cellular protein complex localization (GO:0034629)2.50044314
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.49599268
146negative regulation of vascular permeability (GO:0043116)2.49293399
147phosphorelay signal transduction system (GO:0000160)2.48788370
148negative regulation of gluconeogenesis (GO:0045721)2.48309567
149pericardium development (GO:0060039)2.44370239
150negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43929345
151positive regulation of osteoblast proliferation (GO:0033690)2.43865207
152peptidyl-threonine modification (GO:0018210)2.42449863
153histone deacetylation (GO:0016575)2.42347119
154positive regulation of cardiac muscle hypertrophy (GO:0010613)2.35992221
155positive regulation of muscle hypertrophy (GO:0014742)2.35992221
156regulation of protein polyubiquitination (GO:1902914)2.35019460
157stress granule assembly (GO:0034063)2.32677072
158one-carbon compound transport (GO:0019755)2.32634459
159import into cell (GO:0098657)2.32077524
160cell proliferation involved in kidney development (GO:0072111)2.31867115
161negative regulation of Rho protein signal transduction (GO:0035024)2.31721859
162negative regulation of neurotransmitter transport (GO:0051589)2.31360680
163regulation of skeletal muscle cell differentiation (GO:2001014)2.29659929
164regulation of Rac protein signal transduction (GO:0035020)2.29416980
165definitive hemopoiesis (GO:0060216)2.29159668
166vesicle transport along microtubule (GO:0047496)2.28900415
167pre-miRNA processing (GO:0031054)2.28136075
168N-terminal protein amino acid acetylation (GO:0006474)2.26971755
169detection of calcium ion (GO:0005513)2.26841105
170photoreceptor cell differentiation (GO:0046530)2.26078856
171eye photoreceptor cell differentiation (GO:0001754)2.26078856
172positive regulation of fibroblast migration (GO:0010763)2.25742363
173regulation of cardiac muscle cell contraction (GO:0086004)2.23645113
174insulin-like growth factor receptor signaling pathway (GO:0048009)2.23281665
175histone H3 deacetylation (GO:0070932)2.21568911
176snRNA transcription (GO:0009301)2.20910636
177amyloid precursor protein metabolic process (GO:0042982)2.20227438
178histone H3-K4 methylation (GO:0051568)2.19562580
179astrocyte development (GO:0014002)2.18239346
180neurotransmitter uptake (GO:0001504)2.16634330
181regulation of beta-amyloid formation (GO:1902003)2.16481945
182morphogenesis of an epithelial sheet (GO:0002011)2.14965213
183coronary vasculature morphogenesis (GO:0060977)2.14212255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84315259
2GBX2_23144817_ChIP-Seq_PC3_Human4.19284014
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.33222860
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07520247
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98170402
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90031256
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88103195
8REST_21632747_ChIP-Seq_MESCs_Mouse2.73367502
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56920882
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54208319
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54208319
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52253848
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43388352
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.42219410
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40931071
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37122010
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36893705
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.35683794
19CTNNB1_20460455_ChIP-Seq_HCT116_Human2.33485841
20DROSHA_22980978_ChIP-Seq_HELA_Human2.33266567
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30913720
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28130851
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.25358719
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22079869
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.13329366
26TAF15_26573619_Chip-Seq_HEK293_Human2.10800780
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10130786
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.07715769
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07093147
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06476409
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03897827
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.99102447
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97180093
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91648657
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90520198
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89566421
37SMAD4_21799915_ChIP-Seq_A2780_Human1.88406743
38AR_21572438_ChIP-Seq_LNCaP_Human1.87077898
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.86243401
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84458238
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72902606
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.72292277
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70299318
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70234260
45P300_19829295_ChIP-Seq_ESCs_Human1.68989566
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57172087
47ZNF274_21170338_ChIP-Seq_K562_Hela1.55186424
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53934699
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51381263
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.48613867
51TP53_16413492_ChIP-PET_HCT116_Human1.48180329
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46911581
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45920012
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.44807999
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.43819271
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43133620
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.41599242
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41187310
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39996568
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38951337
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38555243
62IGF1R_20145208_ChIP-Seq_DFB_Human1.38388971
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.36960701
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36921439
65E2F7_22180533_ChIP-Seq_HELA_Human1.36325869
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.35769436
67STAT3_23295773_ChIP-Seq_U87_Human1.35741435
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35360600
69AR_25329375_ChIP-Seq_VCAP_Human1.35150275
70RNF2_27304074_Chip-Seq_NSC_Mouse1.34600918
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33654178
72* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32893406
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31957667
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29712748
75CLOCK_20551151_ChIP-Seq_293T_Human1.29632744
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.28300473
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28105590
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26214466
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.24735717
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.23856102
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23802592
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23623979
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22117773
84* TCF4_23295773_ChIP-Seq_U87_Human1.21768883
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20048851
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19504508
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18709187
88AR_19668381_ChIP-Seq_PC3_Human1.18700228
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18567081
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18342347
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.18110788
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.17283880
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.17163406
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16663600
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15712390
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15626812
97FUS_26573619_Chip-Seq_HEK293_Human1.15527694
98GATA1_19941826_ChIP-Seq_K562_Human1.15083801
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14031436
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13383663
101SCL_19346495_ChIP-Seq_HPC-7_Human1.13038218
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12226944
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11991488
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.11895017
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11106099
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11106099
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10704647
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.10702422
109RUNX2_22187159_ChIP-Seq_PCA_Human1.10382729
110VDR_22108803_ChIP-Seq_LS180_Human1.10036060
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.10005101
112BRD4_25478319_ChIP-Seq_HGPS_Human1.08665834
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08623501
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.08145527
115TCF7_22412390_ChIP-Seq_EML_Mouse1.08114491
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07828834
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07827344
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07194381
119PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06908729
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06760753
121KDM2B_26808549_Chip-Seq_K562_Human1.06550726
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06226776
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05641909
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05641909
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03754593
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03680743
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.03144288
128ER_23166858_ChIP-Seq_MCF-7_Human1.03135648
129ISL1_27105846_Chip-Seq_CPCs_Mouse1.02233202
130AHR_22903824_ChIP-Seq_MCF-7_Human1.02217489
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01694038
132MYC_22102868_ChIP-Seq_BL_Human1.01685339
133GATA2_19941826_ChIP-Seq_K562_Human1.01574676
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01217361
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00512078
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99929380
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99352655
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96597016
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96597016
140JUN_21703547_ChIP-Seq_K562_Human0.96447251
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95511034
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94698864
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94174563
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93971586
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93782608
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.93655857
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93020532
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92865982
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.92575774
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.92252464
151STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91442632
152BCAT_22108803_ChIP-Seq_LS180_Human0.90462329
153* RING1B_27294783_Chip-Seq_NPCs_Mouse0.90382517
154* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89935912
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89649476
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.89246231
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87474402
158TP53_18474530_ChIP-ChIP_U2OS_Human0.87316604
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87122991
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86763180
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.86592245
162ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85758964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29481918
2MP0003880_abnormal_central_pattern4.29486231
3MP0003635_abnormal_synaptic_transmissio3.87119001
4MP0004270_analgesia3.46622802
5MP0009046_muscle_twitch3.40824394
6MP0008057_abnormal_DNA_replication3.33343421
7MP0003283_abnormal_digestive_organ3.26687826
8MP0009745_abnormal_behavioral_response3.26657276
9MP0001968_abnormal_touch/_nociception3.26498789
10MP0002064_seizures3.16778337
11MP0002063_abnormal_learning/memory/cond3.06993711
12MP0002572_abnormal_emotion/affect_behav2.83563506
13MP0002736_abnormal_nociception_after2.83157746
14MP0002272_abnormal_nervous_system2.82359039
15MP0002734_abnormal_mechanical_nocicepti2.63187024
16MP0008961_abnormal_basal_metabolism2.60676019
17MP0001486_abnormal_startle_reflex2.60306960
18MP0002735_abnormal_chemical_nociception2.59693161
19MP0005423_abnormal_somatic_nervous2.54068490
20MP0001501_abnormal_sleep_pattern2.44963446
21MP0001440_abnormal_grooming_behavior2.30733885
22MP0010234_abnormal_vibrissa_follicle2.23520395
23MP0001529_abnormal_vocalization2.22266263
24MP0002822_catalepsy2.21932168
25MP0003890_abnormal_embryonic-extraembry2.18952677
26MP0002067_abnormal_sensory_capabilities2.16057815
27MP0003172_abnormal_lysosome_physiology2.11515807
28MP0010352_gastrointestinal_tract_polyps2.05552668
29MP0006276_abnormal_autonomic_nervous1.99756799
30MP0003656_abnormal_erythrocyte_physiolo1.97621251
31MP0002733_abnormal_thermal_nociception1.95150868
32MP0001970_abnormal_pain_threshold1.93116184
33MP0008569_lethality_at_weaning1.88122968
34MP0000003_abnormal_adipose_tissue1.87403805
35MP0004924_abnormal_behavior1.84469834
36MP0005386_behavior/neurological_phenoty1.84469834
37MP0002184_abnormal_innervation1.78953430
38MP0005646_abnormal_pituitary_gland1.78319166
39MP0003122_maternal_imprinting1.75577225
40MP0002557_abnormal_social/conspecific_i1.74471279
41MP0000778_abnormal_nervous_system1.73412128
42MP0001984_abnormal_olfaction1.70286587
43MP0010678_abnormal_skin_adnexa1.69930548
44MP0009780_abnormal_chondrocyte_physiolo1.68112250
45MP0004185_abnormal_adipocyte_glucose1.67150784
46MP0004142_abnormal_muscle_tone1.66368513
47MP0003879_abnormal_hair_cell1.66339000
48MP0001502_abnormal_circadian_rhythm1.64853780
49MP0002396_abnormal_hematopoietic_system1.64669690
50MP0001188_hyperpigmentation1.63583008
51MP0004808_abnormal_hematopoietic_stem1.62818510
52MP0003045_fibrosis1.58546968
53MP0004858_abnormal_nervous_system1.53923284
54MP0000383_abnormal_hair_follicle1.50418612
55MP0003787_abnormal_imprinting1.49523519
56MP0001905_abnormal_dopamine_level1.49203933
57MP0004811_abnormal_neuron_physiology1.49201463
58MP0003091_abnormal_cell_migration1.48367250
59MP0002882_abnormal_neuron_morphology1.45741690
60MP0000955_abnormal_spinal_cord1.44782390
61MP0003329_amyloid_beta_deposits1.44007155
62MP0005076_abnormal_cell_differentiation1.43585565
63MP0002066_abnormal_motor_capabilities/c1.42090797
64MP0000569_abnormal_digit_pigmentation1.36928471
65MP0002909_abnormal_adrenal_gland1.32821465
66MP0005551_abnormal_eye_electrophysiolog1.32610005
67MP0000462_abnormal_digestive_system1.30451770
68MP0002009_preneoplasia1.29584600
69MP0000428_abnormal_craniofacial_morphol1.26015243
70MP0004145_abnormal_muscle_electrophysio1.21038986
71MP0004885_abnormal_endolymph1.19579230
72MP0001270_distended_abdomen1.18282135
73MP0001944_abnormal_pancreas_morphology1.15454894
74MP0002229_neurodegeneration1.15205085
75MP0005645_abnormal_hypothalamus_physiol1.13350172
76MP0002638_abnormal_pupillary_reflex1.13214528
77MP0000751_myopathy1.12056767
78MP0003633_abnormal_nervous_system1.11458918
79MP0005375_adipose_tissue_phenotype1.10902353
80MP0004742_abnormal_vestibular_system1.10569962
81MP0001730_embryonic_growth_arrest1.05193368
82MP0002152_abnormal_brain_morphology1.03640991
83MP0009840_abnormal_foam_cell1.02905273
84MP0003646_muscle_fatigue1.02888224
85MP0006072_abnormal_retinal_apoptosis1.02805363
86MP0001963_abnormal_hearing_physiology1.00843071
87MP0003868_abnormal_feces_composition1.00817761
88MP0002837_dystrophic_cardiac_calcinosis1.00310603
89MP0003631_nervous_system_phenotype1.00036841
90MP0002876_abnormal_thyroid_physiology0.99823500
91MP0004085_abnormal_heartbeat0.99438359
92MP0003690_abnormal_glial_cell0.97783920
93MP0005621_abnormal_cell_physiology0.96512336
94MP0002752_abnormal_somatic_nervous0.96044588
95MP0003935_abnormal_craniofacial_develop0.94581829
96MP0002084_abnormal_developmental_patter0.94426485
97MP0005409_darkened_coat_color0.94230488
98MP0004264_abnormal_extraembryonic_tissu0.93228448
99MP0002139_abnormal_hepatobiliary_system0.92387199
100MP0003984_embryonic_growth_retardation0.92055273
101MP0002168_other_aberrant_phenotype0.91928633
102MP0003705_abnormal_hypodermis_morpholog0.91446317
103MP0003137_abnormal_impulse_conducting0.91006934
104MP0002069_abnormal_eating/drinking_beha0.90855857
105MP0000631_abnormal_neuroendocrine_gland0.90497329
106MP0003634_abnormal_glial_cell0.90444336
107MP0003453_abnormal_keratinocyte_physiol0.89186469
108MP0001299_abnormal_eye_distance/0.87747782
109MP0002088_abnormal_embryonic_growth/wei0.86062128
110MP0001177_atelectasis0.86016749
111MP0003566_abnormal_cell_adhesion0.85277575
112MP0008872_abnormal_physiological_respon0.85030350
113MP0002060_abnormal_skin_morphology0.84506395
114MP0003195_calcinosis0.84439503
115MP0004215_abnormal_myocardial_fiber0.83777342
116MP0001986_abnormal_taste_sensitivity0.83474267
117MP0006292_abnormal_olfactory_placode0.83104995
118MP0001485_abnormal_pinna_reflex0.82981280
119MP0003115_abnormal_respiratory_system0.82078485
120MP0005380_embryogenesis_phenotype0.81940743
121MP0001672_abnormal_embryogenesis/_devel0.81940743
122MP0005535_abnormal_body_temperature0.81451984
123MP0003123_paternal_imprinting0.80752214
124MP0002332_abnormal_exercise_endurance0.80348139
125MP0010307_abnormal_tumor_latency0.79250712
126MP0003632_abnormal_nervous_system0.78964654
127MP0005058_abnormal_lysosome_morphology0.77546722
128MP0010329_abnormal_lipoprotein_level0.76366009
129MP0010386_abnormal_urinary_bladder0.76231755
130MP0003300_gastrointestinal_ulcer0.75701841
131MP0002086_abnormal_extraembryonic_tissu0.75612455
132MP0001915_intracranial_hemorrhage0.75254736
133MP0003121_genomic_imprinting0.75240538
134MP0002971_abnormal_brown_adipose0.75020119
135MP0003183_abnormal_peptide_metabolism0.72482579
136MP0000920_abnormal_myelination0.72295636
137MP0004484_altered_response_of0.72031690
138MP0008874_decreased_physiological_sensi0.71391268
139MP0009703_decreased_birth_body0.70593510
140MP0002102_abnormal_ear_morphology0.69986876
141MP0002090_abnormal_vision0.69935568
142MP0000013_abnormal_adipose_tissue0.69558468
143MP0005253_abnormal_eye_physiology0.69231796
144MP0005171_absent_coat_pigmentation0.68223928
145MP0001661_extended_life_span0.67735804
146MP0000647_abnormal_sebaceous_gland0.67427110
147MP0000026_abnormal_inner_ear0.67212765
148MP0002751_abnormal_autonomic_nervous0.65762562
149MP0000350_abnormal_cell_proliferation0.65578377
150MP0001348_abnormal_lacrimal_gland0.64453822
151MP0005666_abnormal_adipose_tissue0.64360184
152MP0005394_taste/olfaction_phenotype0.64297760
153MP0005499_abnormal_olfactory_system0.64297760
154MP0001664_abnormal_digestion0.63998158
155MP0002970_abnormal_white_adipose0.63379025
156MP0002138_abnormal_hepatobiliary_system0.63369968
157MP0000639_abnormal_adrenal_gland0.63332386
158MP0005623_abnormal_meninges_morphology0.61068717
159MP0006035_abnormal_mitochondrial_morpho0.59164211
160MP0002653_abnormal_ependyma_morphology0.58234486
161MP0001943_abnormal_respiration0.57058150

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.65318136
2Myokymia (HP:0002411)5.68425202
3Focal seizures (HP:0007359)5.36263752
4Atonic seizures (HP:0010819)5.15187618
5Febrile seizures (HP:0002373)5.00664384
6Visual hallucinations (HP:0002367)4.87662320
7Epileptic encephalopathy (HP:0200134)4.80128731
8Absence seizures (HP:0002121)4.40772356
9Progressive cerebellar ataxia (HP:0002073)4.23167777
10Dialeptic seizures (HP:0011146)4.19843474
11Generalized tonic-clonic seizures (HP:0002069)3.77975139
12Action tremor (HP:0002345)3.36035087
13Peripheral hypomyelination (HP:0007182)3.28213227
14Broad-based gait (HP:0002136)3.28137917
15Gait imbalance (HP:0002141)3.19681491
16Heterotopia (HP:0002282)3.14769601
17Urethral obstruction (HP:0000796)3.13558298
18Gaze-evoked nystagmus (HP:0000640)3.12117948
19Obstructive sleep apnea (HP:0002870)3.07239709
20Hyperventilation (HP:0002883)3.00454512
21Impaired vibration sensation in the lower limbs (HP:0002166)2.99048552
22Depression (HP:0000716)2.93139779
23Congenital primary aphakia (HP:0007707)2.92053621
24Truncal ataxia (HP:0002078)2.89141038
25Supranuclear gaze palsy (HP:0000605)2.87868254
26Scanning speech (HP:0002168)2.86245269
27Dysdiadochokinesis (HP:0002075)2.80526155
28Limb dystonia (HP:0002451)2.77982131
29Double outlet right ventricle (HP:0001719)2.77470617
30Congenital malformation of the right heart (HP:0011723)2.77470617
31Nephrogenic diabetes insipidus (HP:0009806)2.74858644
32Dysmetria (HP:0001310)2.74480820
33Medial flaring of the eyebrow (HP:0010747)2.71115198
34Abnormal eating behavior (HP:0100738)2.70523852
35Anxiety (HP:0000739)2.70112174
36Macroorchidism (HP:0000053)2.69750670
37Pheochromocytoma (HP:0002666)2.66108061
38Urinary bladder sphincter dysfunction (HP:0002839)2.66010053
39Hemiparesis (HP:0001269)2.61562598
40Abnormal hair whorl (HP:0010721)2.61558909
41Ankle clonus (HP:0011448)2.59345154
42Insidious onset (HP:0003587)2.58377995
43Termporal pattern (HP:0011008)2.58377995
44Abnormality of the fingertips (HP:0001211)2.56227154
45Impaired smooth pursuit (HP:0007772)2.54058512
46Autoamputation (HP:0001218)2.54002320
47Abnormality of the corticospinal tract (HP:0002492)2.53636526
48Genetic anticipation (HP:0003743)2.53520485
49Anal stenosis (HP:0002025)2.49826970
50Broad face (HP:0000283)2.48856362
51Polyphagia (HP:0002591)2.47939012
52Fetal akinesia sequence (HP:0001989)2.47077737
53Genital tract atresia (HP:0001827)2.47060791
54Vaginal atresia (HP:0000148)2.46910150
55Poor eye contact (HP:0000817)2.45395625
56Amblyopia (HP:0000646)2.44506913
57Chin dimple (HP:0010751)2.41619900
58Diplopia (HP:0000651)2.40401841
59Abnormality of binocular vision (HP:0011514)2.40401841
60Abnormality of chromosome segregation (HP:0002916)2.40179079
61Calf muscle hypertrophy (HP:0008981)2.39607915
62Specific learning disability (HP:0001328)2.38082249
63Postural tremor (HP:0002174)2.37970781
64Drooling (HP:0002307)2.35788596
65Excessive salivation (HP:0003781)2.35788596
66Neuroendocrine neoplasm (HP:0100634)2.34220145
67Epileptiform EEG discharges (HP:0011182)2.34150672
68Acute myeloid leukemia (HP:0004808)2.33957076
69Prolonged QT interval (HP:0001657)2.32521164
70Pulmonic stenosis (HP:0001642)2.31850384
71Glucose intolerance (HP:0000833)2.30912208
72Sparse lateral eyebrow (HP:0005338)2.30040003
73Ventricular fibrillation (HP:0001663)2.29573130
74Status epilepticus (HP:0002133)2.28461723
75Bradykinesia (HP:0002067)2.27682765
76Progressive inability to walk (HP:0002505)2.26614292
77Abnormal social behavior (HP:0012433)2.25567403
78Impaired social interactions (HP:0000735)2.25567403
79Hypothermia (HP:0002045)2.25565814
80Poor coordination (HP:0002370)2.24719435
81Postural instability (HP:0002172)2.23993850
82Abnormal ventriculo-arterial connection (HP:0011563)2.23306766
83Transposition of the great arteries (HP:0001669)2.23306766
84Abnormal connection of the cardiac segments (HP:0011545)2.23306766
85Spastic gait (HP:0002064)2.23074212
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.22885133
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22885133
88Papillary thyroid carcinoma (HP:0002895)2.21826869
89Increased circulating renin level (HP:0000848)2.18702667
90Intestinal atresia (HP:0011100)2.16529519
91Urinary urgency (HP:0000012)2.15586862
92Abnormality of the labia minora (HP:0012880)2.15512981
93Increased number of teeth (HP:0011069)2.15500472
94Hemiplegia (HP:0002301)2.14088886
95EEG with generalized epileptiform discharges (HP:0011198)2.13988343
96Retinal dysplasia (HP:0007973)2.13555018
97Spastic tetraparesis (HP:0001285)2.11160674
98Abnormality of ocular smooth pursuit (HP:0000617)2.11007590
99Bowel incontinence (HP:0002607)2.08562223
100Ankyloglossia (HP:0010296)2.07258651
101Neurofibrillary tangles (HP:0002185)2.05706103
102Impaired vibratory sensation (HP:0002495)2.04947104
103Mild short stature (HP:0003502)2.04843495
104Overgrowth (HP:0001548)2.03529205
105Oligomenorrhea (HP:0000876)2.03479936
106Deep philtrum (HP:0002002)2.03405436
107Abnormal EKG (HP:0003115)2.03152756
108Laryngomalacia (HP:0001601)2.02643807
109Obsessive-compulsive behavior (HP:0000722)2.02462040
110Acute necrotizing encephalopathy (HP:0006965)2.01967709
111Failure to thrive in infancy (HP:0001531)2.01822234
112Poor suck (HP:0002033)2.01282924
113Lower limb muscle weakness (HP:0007340)2.01219025
114Absent speech (HP:0001344)2.01140030
115Syncope (HP:0001279)1.99554345
116Oligodactyly (hands) (HP:0001180)1.99336010
117Long eyelashes (HP:0000527)1.98864538
118Narrow palate (HP:0000189)1.97317675
119Abnormal mitochondria in muscle tissue (HP:0008316)1.96951635
120Mitral stenosis (HP:0001718)1.96715211
121Focal dystonia (HP:0004373)1.95838682
122Hypsarrhythmia (HP:0002521)1.95252852
123Generalized myoclonic seizures (HP:0002123)1.94382219
124Alacrima (HP:0000522)1.93370098
125Lower limb hyperreflexia (HP:0002395)1.93281631
126Abnormality of the lower motor neuron (HP:0002366)1.92609779
127Protruding tongue (HP:0010808)1.91579633
128Cubitus valgus (HP:0002967)1.90393710
129Incomplete penetrance (HP:0003829)1.90349061
130Lip pit (HP:0100267)1.89289109
131Psychosis (HP:0000709)1.89039601
132Esotropia (HP:0000565)1.88941556
133Abnormal auditory evoked potentials (HP:0006958)1.88882381
134Nuclear cataract (HP:0100018)1.88677331
135Inability to walk (HP:0002540)1.87266306
136Torticollis (HP:0000473)1.87163795
137Germ cell neoplasia (HP:0100728)1.86233976
138Subacute progressive viral hepatitis (HP:0006572)1.86117974
139Hypoglycemic seizures (HP:0002173)1.85699685
140Abnormal large intestine physiology (HP:0012700)1.84541457
141Progressive macrocephaly (HP:0004481)1.84125722
142Thickened helices (HP:0000391)1.83907058
143Neoplasm of the oral cavity (HP:0100649)1.83880526
144Muscle hypertrophy of the lower extremities (HP:0008968)1.83239346
145Megalencephaly (HP:0001355)1.82846435
146Agitation (HP:0000713)1.81253118
147Mucopolysacchariduria (HP:0008155)1.80743907
148Urinary glycosaminoglycan excretion (HP:0003541)1.80743907
149Menstrual irregularities (HP:0000858)1.79578709
150Aqueductal stenosis (HP:0002410)1.79294067
151Acute lymphatic leukemia (HP:0006721)1.79216314
152Prominent nose (HP:0000448)1.78838188
153Dysmetric saccades (HP:0000641)1.78544423
154Dislocated radial head (HP:0003083)1.77060388
155Abnormal glucose tolerance (HP:0001952)1.76455212
156Pancreatic fibrosis (HP:0100732)1.75993242
157Neoplasm of the heart (HP:0100544)1.75416660
158Progressive sensorineural hearing impairment (HP:0000408)1.73532699
159Left ventricular hypertrophy (HP:0001712)1.73085767
160Cerebral inclusion bodies (HP:0100314)1.72594007
161Progressive hearing impairment (HP:0001730)1.72528147
162Insomnia (HP:0100785)1.71671895
163Truncal obesity (HP:0001956)1.71589787
164Unilateral renal agenesis (HP:0000122)1.69617878
165Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.68811301
166Increased CSF protein (HP:0002922)1.67668199
167Decreased motor nerve conduction velocity (HP:0003431)1.67513851
168Hyperglycemia (HP:0003074)1.67407462
169Abnormal pancreas size (HP:0012094)1.66804492
170Dyschromatopsia (HP:0007641)1.66206280
171Tapered finger (HP:0001182)1.66075685
172Impaired pain sensation (HP:0007328)1.65781508
173Abnormality of pain sensation (HP:0010832)1.65781508
174Intestinal fistula (HP:0100819)1.65167709
175Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65039663
176Turricephaly (HP:0000262)1.64959602
177Testicular neoplasm (HP:0010788)1.64907272
178Hyperinsulinemic hypoglycemia (HP:0000825)1.64366238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.83085641
2EPHA44.52345278
3CDK124.46595941
4CASK3.49083489
5MAP3K43.17811478
6MAP2K73.06693970
7ICK3.01616942
8MAP3K92.74339198
9TNIK2.51486885
10BRD42.47110402
11NTRK22.43822589
12MARK12.41543838
13CAMK1D2.39022793
14MAP2K32.33574836
15MINK12.33002281
16MAP3K122.00004267
17WNK11.89000485
18MAP2K41.87434773
19DAPK21.81002340
20PAK61.78783692
21MAPK131.78134034
22AKT31.71582502
23ERBB41.69444944
24CDK191.67556430
25PLK21.63497371
26ZAP701.58009253
27PRPF4B1.57135081
28KSR11.43659274
29ARAF1.42552890
30SGK4941.42473602
31SGK2231.42473602
32RIPK41.41993031
33SGK21.41044862
34KSR21.40722285
35SIK31.37747971
36CDK51.35041008
37OXSR11.34693127
38FES1.31573833
39CAMKK21.29760540
40NTRK11.26244893
41DAPK11.24819654
42FGFR31.24503234
43CAMK2B1.23864728
44MTOR1.23794809
45PNCK1.20386412
46CAMK2A1.19213262
47GRK51.18046417
48PRKCG1.17149153
49PDGFRA1.15019828
50TNK21.14814677
51CAMKK11.10120380
52PHKG21.06623790
53PHKG11.06623790
54MAP3K141.04741591
55TSSK61.03897807
56DMPK1.03053823
57MELK1.02074128
58PDGFRB1.01033356
59NEK90.98924401
60MAP2K60.98735120
61MKNK20.97941633
62NLK0.96585647
63BRAF0.95662581
64MAP3K70.94937668
65UHMK10.93651047
66PRKD30.93455542
67MAP3K130.92908726
68TRIB30.91575275
69CSNK1G20.90128458
70BCR0.89538839
71BMX0.87741257
72SGK30.85115480
73CDK180.83548433
74SCYL20.82821354
75EPHB10.79985596
76FGFR40.79333676
77MAP3K20.79301614
78CDK140.78873874
79RPS6KA20.78773707
80IRAK20.78683969
81STK380.77832110
82TRPM70.77766951
83CAMK2D0.76649023
84MAPK110.76167442
85CDK150.75722055
86ACVR1B0.75647416
87CAMK10.75566071
88CAMK2G0.74890593
89PRKCE0.74236212
90FRK0.74043164
91ALK0.73559389
92LATS10.73555936
93MAP3K50.73297642
94JAK10.73186918
95MAPK70.71570492
96SGK10.70847277
97MUSK0.69108258
98MAP2K10.67845193
99PAK30.66797206
100BRSK20.66255647
101RPS6KB10.65962272
102STK110.65890236
103FGFR20.65412015
104CDK11A0.64611500
105SIK10.64593408
106WNK30.63326012
107BMPR20.63225680
108SIK20.61417450
109STK30.61394969
110CCNB10.61093977
111EEF2K0.59941675
112CDK30.58771389
113RIPK10.57380993
114MAPKAPK50.57214744
115MAP3K60.56472671
116MAP3K100.54353138
117MARK20.54285691
118PTK20.54211972
119CDC42BPA0.53965315
120RPS6KA30.53790811
121MAPK120.53286603
122DYRK1A0.52063495
123CHUK0.51642193
124LMTK20.50764360
125GSK3B0.50442138
126CHEK10.49204312
127PRKAA10.49143081
128WEE10.48846043
129CSNK1G30.48819443
130FER0.48374517
131STK38L0.48092684
132PRKG10.47270571
133PKN20.47108957
134ROCK10.46935844
135PRKCH0.46345701
136CSNK1D0.46060967
137PRKACA0.45784294
138PTK2B0.45194496
139ROCK20.45117879
140PKN10.43762377
141MET0.43305601
142NME10.43102817
143MAPK100.42148858
144PDK10.41935726
145BRSK10.41846759
146CLK10.41602831
147RAF10.40590009
148MAPK10.40497283
149TAOK10.40101602
150CAMK1G0.39270480
151RET0.39034104
152PRKCB0.38502883
153LATS20.38327259
154NEK60.38233220
155ADRBK10.37595424
156PDPK10.36985778
157CAMK40.35371137
158PINK10.35360331
159INSRR0.35236083

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22373746
2Synaptic vesicle cycle_Homo sapiens_hsa047213.63303887
3GABAergic synapse_Homo sapiens_hsa047272.89149550
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79811299
5Circadian entrainment_Homo sapiens_hsa047132.67335603
6Amphetamine addiction_Homo sapiens_hsa050312.66552878
7Morphine addiction_Homo sapiens_hsa050322.65880134
8Glutamatergic synapse_Homo sapiens_hsa047242.59729095
9Olfactory transduction_Homo sapiens_hsa047402.53851473
10Long-term potentiation_Homo sapiens_hsa047202.39148741
11Collecting duct acid secretion_Homo sapiens_hsa049662.29031028
12Taste transduction_Homo sapiens_hsa047422.21340164
13Dopaminergic synapse_Homo sapiens_hsa047282.20757757
14Insulin secretion_Homo sapiens_hsa049112.14433975
15Salivary secretion_Homo sapiens_hsa049702.05891583
16Cocaine addiction_Homo sapiens_hsa050302.03396802
17Serotonergic synapse_Homo sapiens_hsa047261.87572590
18Cholinergic synapse_Homo sapiens_hsa047251.82969539
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82846155
20Long-term depression_Homo sapiens_hsa047301.69507779
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66789793
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60495395
23Gastric acid secretion_Homo sapiens_hsa049711.59211905
24Chronic myeloid leukemia_Homo sapiens_hsa052201.55010139
25Calcium signaling pathway_Homo sapiens_hsa040201.53151044
26Renin secretion_Homo sapiens_hsa049241.50777213
27Vibrio cholerae infection_Homo sapiens_hsa051101.47436133
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46490202
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45933829
30Oxytocin signaling pathway_Homo sapiens_hsa049211.41463874
31Endometrial cancer_Homo sapiens_hsa052131.38241782
32Non-small cell lung cancer_Homo sapiens_hsa052231.38217454
33mTOR signaling pathway_Homo sapiens_hsa041501.34840174
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32544530
35Notch signaling pathway_Homo sapiens_hsa043301.28267547
36cAMP signaling pathway_Homo sapiens_hsa040241.27858309
37Cardiac muscle contraction_Homo sapiens_hsa042601.19094397
38Renal cell carcinoma_Homo sapiens_hsa052111.17788957
39Gap junction_Homo sapiens_hsa045401.17386348
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17316450
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16879451
42GnRH signaling pathway_Homo sapiens_hsa049121.16712604
43Phototransduction_Homo sapiens_hsa047441.15996290
44mRNA surveillance pathway_Homo sapiens_hsa030151.15767233
45Oxidative phosphorylation_Homo sapiens_hsa001901.15730366
46MicroRNAs in cancer_Homo sapiens_hsa052061.14288761
47Prostate cancer_Homo sapiens_hsa052151.14148819
48Pancreatic cancer_Homo sapiens_hsa052121.13954583
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12450843
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11801783
51FoxO signaling pathway_Homo sapiens_hsa040681.09972291
52Acute myeloid leukemia_Homo sapiens_hsa052211.09930526
53Lysine degradation_Homo sapiens_hsa003101.09483875
54Prolactin signaling pathway_Homo sapiens_hsa049171.08404993
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06745683
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06455937
57Estrogen signaling pathway_Homo sapiens_hsa049151.00982285
58Axon guidance_Homo sapiens_hsa043601.00545334
59VEGF signaling pathway_Homo sapiens_hsa043701.00360332
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.99478004
61Adherens junction_Homo sapiens_hsa045200.99042547
62Type II diabetes mellitus_Homo sapiens_hsa049300.97373414
63Proteoglycans in cancer_Homo sapiens_hsa052050.96364012
64Colorectal cancer_Homo sapiens_hsa052100.96332895
65Melanogenesis_Homo sapiens_hsa049160.94878699
66AMPK signaling pathway_Homo sapiens_hsa041520.94728508
67B cell receptor signaling pathway_Homo sapiens_hsa046620.93398853
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90891905
69Bile secretion_Homo sapiens_hsa049760.90882084
70Circadian rhythm_Homo sapiens_hsa047100.88808134
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86721848
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.84594613
73Alzheimers disease_Homo sapiens_hsa050100.84480791
74ErbB signaling pathway_Homo sapiens_hsa040120.81650793
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78812928
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78188880
77Parkinsons disease_Homo sapiens_hsa050120.77616926
78Thyroid hormone synthesis_Homo sapiens_hsa049180.77392146
79Insulin resistance_Homo sapiens_hsa049310.76019775
80Glioma_Homo sapiens_hsa052140.74690117
81Pancreatic secretion_Homo sapiens_hsa049720.72297527
82Hepatitis C_Homo sapiens_hsa051600.71900310
83Type I diabetes mellitus_Homo sapiens_hsa049400.71343484
84Oocyte meiosis_Homo sapiens_hsa041140.70175853
85Dilated cardiomyopathy_Homo sapiens_hsa054140.69823585
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69649334
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66673341
88Dorso-ventral axis formation_Homo sapiens_hsa043200.66366228
89TGF-beta signaling pathway_Homo sapiens_hsa043500.65050300
90Platelet activation_Homo sapiens_hsa046110.64362791
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62524675
92Small cell lung cancer_Homo sapiens_hsa052220.61732997
93Hippo signaling pathway_Homo sapiens_hsa043900.61328149
94Focal adhesion_Homo sapiens_hsa045100.60895186
95Alcoholism_Homo sapiens_hsa050340.60802009
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58745618
97MAPK signaling pathway_Homo sapiens_hsa040100.58299639
98Glucagon signaling pathway_Homo sapiens_hsa049220.57867370
99Hepatitis B_Homo sapiens_hsa051610.57865320
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.57814540
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56542746
102T cell receptor signaling pathway_Homo sapiens_hsa046600.55891226
103Inositol phosphate metabolism_Homo sapiens_hsa005620.55849850
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55267694
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54299537
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.53705040
107Huntingtons disease_Homo sapiens_hsa050160.53253911
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.51280310
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.50781909
110Rheumatoid arthritis_Homo sapiens_hsa053230.49519817
111Choline metabolism in cancer_Homo sapiens_hsa052310.49398357
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48501648
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47771141
114Ras signaling pathway_Homo sapiens_hsa040140.46430641
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43171321
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.42274384
117Vitamin B6 metabolism_Homo sapiens_hsa007500.41441982
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39398371
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39334273
120Ovarian steroidogenesis_Homo sapiens_hsa049130.38694338
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38377117
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37637132
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37330071
124Fatty acid biosynthesis_Homo sapiens_hsa000610.35276787
125Prion diseases_Homo sapiens_hsa050200.35120321
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.35103184
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.34589970
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34547261
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33827064
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32831568
131Wnt signaling pathway_Homo sapiens_hsa043100.32255920
132Rap1 signaling pathway_Homo sapiens_hsa040150.31361501
133Regulation of autophagy_Homo sapiens_hsa041400.29453189
134Hedgehog signaling pathway_Homo sapiens_hsa043400.28361093
135Insulin signaling pathway_Homo sapiens_hsa049100.27409341
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26685666
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26445555
138Phagosome_Homo sapiens_hsa041450.25497870

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