GPR75-ASB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise identical to that encoded by ASB3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to xenobiotic stimulus (GO:0009410)6.71505097
2fucose catabolic process (GO:0019317)5.64091935
3L-fucose metabolic process (GO:0042354)5.64091935
4L-fucose catabolic process (GO:0042355)5.64091935
5protein polyglutamylation (GO:0018095)4.81220741
6heparin biosynthetic process (GO:0030210)4.76445553
7heparin metabolic process (GO:0030202)4.76445553
8rRNA catabolic process (GO:0016075)4.71757956
9response to nitrosative stress (GO:0051409)4.63544942
10regulation of cilium movement (GO:0003352)4.60224612
11DNA deamination (GO:0045006)4.59088330
12cysteine metabolic process (GO:0006534)4.57953765
13positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.06235291
14positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.06235291
15positive regulation of mitotic sister chromatid separation (GO:1901970)4.06235291
16S-adenosylmethionine metabolic process (GO:0046500)4.05107936
17positive regulation of protein homodimerization activity (GO:0090073)3.88979996
18negative regulation of T cell differentiation in thymus (GO:0033085)3.68080906
19preassembly of GPI anchor in ER membrane (GO:0016254)3.61879224
20platelet dense granule organization (GO:0060155)3.61358015
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.53294628
22neural tube formation (GO:0001841)3.52458686
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51467844
24L-ascorbic acid metabolic process (GO:0019852)3.47375501
25protein-cofactor linkage (GO:0018065)3.45783043
26intra-S DNA damage checkpoint (GO:0031573)3.45623336
27pseudouridine synthesis (GO:0001522)3.44138064
28negative regulation of protein oligomerization (GO:0032460)3.39225134
29prostate gland growth (GO:0060736)3.39157939
30serotonin receptor signaling pathway (GO:0007210)3.37510408
31maturation of 5.8S rRNA (GO:0000460)3.37142120
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32617039
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26955858
34water-soluble vitamin biosynthetic process (GO:0042364)3.10994734
35proteasome assembly (GO:0043248)3.10258759
36inositol phosphate catabolic process (GO:0071545)3.07889092
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07198293
38lactate metabolic process (GO:0006089)3.04299361
39cornea development in camera-type eye (GO:0061303)3.01917607
40ubiquinone biosynthetic process (GO:0006744)3.01622367
41regulation of microtubule-based movement (GO:0060632)3.01258544
42protein localization to peroxisome (GO:0072662)2.97279737
43protein targeting to peroxisome (GO:0006625)2.97279737
44establishment of protein localization to peroxisome (GO:0072663)2.97279737
45regulation of thymocyte apoptotic process (GO:0070243)2.96453239
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94192520
47mitochondrial respiratory chain complex I assembly (GO:0032981)2.94192520
48NADH dehydrogenase complex assembly (GO:0010257)2.94192520
49cellular ketone body metabolic process (GO:0046950)2.93808596
50response to gravity (GO:0009629)2.93663577
51isotype switching (GO:0045190)2.91323391
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91323391
53somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91323391
54maternal behavior (GO:0042711)2.90302851
55tryptophan catabolic process (GO:0006569)2.89996737
56indole-containing compound catabolic process (GO:0042436)2.89996737
57indolalkylamine catabolic process (GO:0046218)2.89996737
58protein complex biogenesis (GO:0070271)2.88796193
59mannosylation (GO:0097502)2.88301171
60fucosylation (GO:0036065)2.86977754
61glutathione biosynthetic process (GO:0006750)2.86690486
62phosphorylated carbohydrate dephosphorylation (GO:0046838)2.83000839
63inositol phosphate dephosphorylation (GO:0046855)2.83000839
64fucose metabolic process (GO:0006004)2.82843250
65replication fork processing (GO:0031297)2.81329180
66nonribosomal peptide biosynthetic process (GO:0019184)2.79778464
67behavioral response to ethanol (GO:0048149)2.79254841
68dendritic spine morphogenesis (GO:0060997)2.76721784
69C-terminal protein amino acid modification (GO:0018410)2.76641182
70kynurenine metabolic process (GO:0070189)2.75437009
71mitochondrial respiratory chain complex assembly (GO:0033108)2.74691107
72ncRNA catabolic process (GO:0034661)2.74661713
73nonmotile primary cilium assembly (GO:0035058)2.73818354
74protein K6-linked ubiquitination (GO:0085020)2.73102313
75resolution of meiotic recombination intermediates (GO:0000712)2.71215948
76arginine catabolic process (GO:0006527)2.70833971
77parental behavior (GO:0060746)2.70729377
78viral mRNA export from host cell nucleus (GO:0046784)2.70421189
79C-terminal protein lipidation (GO:0006501)2.70258734
80polyol catabolic process (GO:0046174)2.69773707
81opioid receptor signaling pathway (GO:0038003)2.69425478
82protein K48-linked ubiquitination (GO:0070936)2.67748868
83nephron tubule morphogenesis (GO:0072078)2.65672690
84nephron epithelium morphogenesis (GO:0072088)2.65672690
85positive regulation of T cell apoptotic process (GO:0070234)2.63500285
86negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62817113
87epithelial cilium movement (GO:0003351)2.61564215
88centriole replication (GO:0007099)2.61327144
89coenzyme catabolic process (GO:0009109)2.60518278
90presynaptic membrane organization (GO:0097090)2.58955254
91cytochrome complex assembly (GO:0017004)2.56746227
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.56224797
93termination of RNA polymerase III transcription (GO:0006386)2.56224797
94ubiquinone metabolic process (GO:0006743)2.56000850
95respiratory chain complex IV assembly (GO:0008535)2.55662670
96tryptophan metabolic process (GO:0006568)2.55597176
97ketone body metabolic process (GO:1902224)2.53210132
98retinal ganglion cell axon guidance (GO:0031290)2.52572633
99cellular response to ATP (GO:0071318)2.51892054
100kidney morphogenesis (GO:0060993)2.50455500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.67550516
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.12376492
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54541591
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.48377046
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12541715
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03067137
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.91716040
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.87130456
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84791264
10IGF1R_20145208_ChIP-Seq_DFB_Human2.61031282
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56862127
12VDR_22108803_ChIP-Seq_LS180_Human2.45346383
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36992937
14TAF15_26573619_Chip-Seq_HEK293_Human2.27996725
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18379986
16GBX2_23144817_ChIP-Seq_PC3_Human2.16758039
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14990942
18EWS_26573619_Chip-Seq_HEK293_Human2.14503429
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12674534
20P300_19829295_ChIP-Seq_ESCs_Human2.11028489
21FUS_26573619_Chip-Seq_HEK293_Human2.10509033
22VDR_23849224_ChIP-Seq_CD4+_Human2.10078158
23MYC_18940864_ChIP-ChIP_HL60_Human2.06783446
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.96631799
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94778639
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.94623378
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81825327
28ELK1_19687146_ChIP-ChIP_HELA_Human1.77003072
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.72392221
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63426409
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62640218
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59113844
33FOXP3_21729870_ChIP-Seq_TREG_Human1.52511577
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.52349481
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45502141
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.45392666
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41047134
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40849545
39CBP_20019798_ChIP-Seq_JUKART_Human1.40849545
40TP53_22573176_ChIP-Seq_HFKS_Human1.38509520
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.38471052
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37448649
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35512044
44TCF4_23295773_ChIP-Seq_U87_Human1.33313642
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32047472
46AR_25329375_ChIP-Seq_VCAP_Human1.31984589
47SALL4_22934838_ChIP-ChIP_CD34+_Human1.31085869
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21881252
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20568756
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20415974
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19985073
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17913010
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17797291
54RNF2_27304074_Chip-Seq_NSC_Mouse1.17504116
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17455891
56NCOR_22424771_ChIP-Seq_293T_Human1.16742104
57SOX2_19829295_ChIP-Seq_ESCs_Human1.15460667
58NANOG_19829295_ChIP-Seq_ESCs_Human1.15460667
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14267816
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.12296192
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.10807108
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.10507076
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10439378
64STAT3_23295773_ChIP-Seq_U87_Human1.09226429
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.07845900
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06360221
67HOXB7_26014856_ChIP-Seq_BT474_Human1.06323679
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.05785810
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05785810
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05370900
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05370900
72EGR1_19032775_ChIP-ChIP_M12_Human1.04109415
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03671422
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03124415
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03078934
76SMAD4_21799915_ChIP-Seq_A2780_Human1.01836802
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.01487123
78ER_23166858_ChIP-Seq_MCF-7_Human1.01195060
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00575686
80E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98827265
81REST_21632747_ChIP-Seq_MESCs_Mouse0.98715027
82IRF1_19129219_ChIP-ChIP_H3396_Human0.97967227
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97938218
84BCAT_22108803_ChIP-Seq_LS180_Human0.96915550
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96013953
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95908671
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95621756
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95490578
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95159800
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93899475
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93265805
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93167205
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93065726
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92431029
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92035040
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91703275
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91581987
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91540944
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91205483
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90177327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis4.13484797
2MP0001984_abnormal_olfaction2.72587978
3MP0005253_abnormal_eye_physiology2.52052459
4MP0006292_abnormal_olfactory_placode2.50046080
5MP0001986_abnormal_taste_sensitivity2.47060562
6MP0001968_abnormal_touch/_nociception2.45290343
7MP0005645_abnormal_hypothalamus_physiol2.39353047
8MP0008789_abnormal_olfactory_epithelium2.24194427
9MP0002102_abnormal_ear_morphology2.24117606
10MP0008877_abnormal_DNA_methylation2.19785051
11MP0003718_maternal_effect2.15749363
12MP0008775_abnormal_heart_ventricle2.08334561
13MP0008875_abnormal_xenobiotic_pharmacok2.04184952
14MP0002160_abnormal_reproductive_system1.94572840
15MP0003186_abnormal_redox_activity1.93851789
16MP0003880_abnormal_central_pattern1.91086910
17MP0002876_abnormal_thyroid_physiology1.88939077
18MP0002751_abnormal_autonomic_nervous1.86804245
19MP0005394_taste/olfaction_phenotype1.85710447
20MP0005499_abnormal_olfactory_system1.85710447
21MP0005220_abnormal_exocrine_pancreas1.83326547
22MP0001529_abnormal_vocalization1.80562982
23MP0002736_abnormal_nociception_after1.75263665
24MP0005084_abnormal_gallbladder_morpholo1.70877181
25MP0002837_dystrophic_cardiac_calcinosis1.70354278
26MP0001501_abnormal_sleep_pattern1.70210257
27MP0005646_abnormal_pituitary_gland1.68792705
28MP0001440_abnormal_grooming_behavior1.68028315
29MP0003787_abnormal_imprinting1.66814315
30MP0001905_abnormal_dopamine_level1.64336019
31MP0002254_reproductive_system_inflammat1.58739167
32MP0003890_abnormal_embryonic-extraembry1.55508108
33MP0008872_abnormal_physiological_respon1.53870269
34MP0005551_abnormal_eye_electrophysiolog1.48889974
35MP0008057_abnormal_DNA_replication1.47909417
36MP0003121_genomic_imprinting1.46474426
37MP0002272_abnormal_nervous_system1.45761363
38MP0009046_muscle_twitch1.45710329
39MP0000427_abnormal_hair_cycle1.45649380
40MP0005423_abnormal_somatic_nervous1.44911037
41MP0002928_abnormal_bile_duct1.44270091
42MP0004142_abnormal_muscle_tone1.44046640
43MP0005367_renal/urinary_system_phenotyp1.43267416
44MP0000516_abnormal_urinary_system1.43267416
45MP0003011_delayed_dark_adaptation1.41222374
46MP0004885_abnormal_endolymph1.40681775
47MP0005389_reproductive_system_phenotype1.37321066
48MP0009745_abnormal_behavioral_response1.35189579
49MP0003252_abnormal_bile_duct1.28966463
50MP0005386_behavior/neurological_phenoty1.26453339
51MP0004924_abnormal_behavior1.26453339
52MP0004133_heterotaxia1.25498127
53MP0000631_abnormal_neuroendocrine_gland1.25316593
54MP0001944_abnormal_pancreas_morphology1.25232223
55MP0008007_abnormal_cellular_replicative1.24279726
56MP0004134_abnormal_chest_morphology1.22734392
57MP0001764_abnormal_homeostasis1.13973649
58MP0002184_abnormal_innervation1.13523158
59MP0002572_abnormal_emotion/affect_behav1.12808747
60MP0005083_abnormal_biliary_tract1.09777561
61MP0002064_seizures1.09041291
62MP0004043_abnormal_pH_regulation1.08944742
63MP0003122_maternal_imprinting1.08212840
64MP0006276_abnormal_autonomic_nervous1.07401952
65MP0004215_abnormal_myocardial_fiber1.02302399
66MP0009764_decreased_sensitivity_to1.01252463
67MP0002282_abnormal_trachea_morphology1.00482197
68MP0009697_abnormal_copulation1.00219132
69MP0000685_abnormal_immune_system0.99920045
70MP0004145_abnormal_muscle_electrophysio0.97423583
71MP0002733_abnormal_thermal_nociception0.97187656
72MP0002067_abnormal_sensory_capabilities0.94655686
73MP0003633_abnormal_nervous_system0.93594771
74MP0008058_abnormal_DNA_repair0.93517562
75MP0000013_abnormal_adipose_tissue0.93375129
76MP0000955_abnormal_spinal_cord0.89596174
77MP0005391_vision/eye_phenotype0.89071886
78MP0002693_abnormal_pancreas_physiology0.88523690
79MP0003329_amyloid_beta_deposits0.86061826
80MP0002234_abnormal_pharynx_morphology0.84826148
81MP0006035_abnormal_mitochondrial_morpho0.82714198
82MP0005395_other_phenotype0.81756377
83MP0001486_abnormal_startle_reflex0.81530707
84MP0008932_abnormal_embryonic_tissue0.81298958
85MP0003635_abnormal_synaptic_transmissio0.80824058
86MP0002229_neurodegeneration0.80750388
87MP0003436_decreased_susceptibility_to0.78059915
88MP0004782_abnormal_surfactant_physiolog0.76310490
89MP0003172_abnormal_lysosome_physiology0.75551051
90MP0000383_abnormal_hair_follicle0.75295392
91MP0002638_abnormal_pupillary_reflex0.74384222
92MP0000015_abnormal_ear_pigmentation0.73919169
93MP0002909_abnormal_adrenal_gland0.73822552
94MP0002557_abnormal_social/conspecific_i0.72729203
95MP0001970_abnormal_pain_threshold0.72704827
96MP0003045_fibrosis0.72551414
97MP0005647_abnormal_sex_gland0.72273139
98MP0000230_abnormal_systemic_arterial0.71832561
99MP0003943_abnormal_hepatobiliary_system0.69055623
100MP0000750_abnormal_muscle_regeneration0.68213715

Predicted human phenotypes

RankGene SetZ-score
1Progressive macrocephaly (HP:0004481)4.39569984
2Acute necrotizing encephalopathy (HP:0006965)4.15722904
3Tubulointerstitial nephritis (HP:0001970)3.81555316
4Abnormal mitochondria in muscle tissue (HP:0008316)3.59974142
5Medial flaring of the eyebrow (HP:0010747)3.58758227
6Stomach cancer (HP:0012126)3.53288834
7Abnormality of the renal cortex (HP:0011035)3.45808790
8Enlarged kidneys (HP:0000105)3.44574457
9Type II lissencephaly (HP:0007260)3.37149273
10Renal cortical cysts (HP:0000803)3.30835039
11Acute encephalopathy (HP:0006846)3.27951434
12Reduced antithrombin III activity (HP:0001976)3.21940800
13Abnormality of the renal medulla (HP:0100957)3.17866045
14Ketoacidosis (HP:0001993)3.10107751
15Pancreatic cysts (HP:0001737)3.05810344
16Stomatitis (HP:0010280)2.99427559
17Inability to walk (HP:0002540)2.94904813
18Nephronophthisis (HP:0000090)2.88910746
19Rectovaginal fistula (HP:0000143)2.87575609
20Rectal fistula (HP:0100590)2.87575609
21Pancreatic islet-cell hyperplasia (HP:0004510)2.84342380
22Abnormality of midbrain morphology (HP:0002418)2.80587427
23Molar tooth sign on MRI (HP:0002419)2.80587427
24Broad-based gait (HP:0002136)2.74969185
25Pancreatic fibrosis (HP:0100732)2.72307900
26Ketosis (HP:0001946)2.70922362
27Mitochondrial inheritance (HP:0001427)2.68175014
28Cerebral edema (HP:0002181)2.64693148
29Chorioretinal atrophy (HP:0000533)2.63625192
30Gait imbalance (HP:0002141)2.62894959
31Pendular nystagmus (HP:0012043)2.60477672
32Congenital primary aphakia (HP:0007707)2.58331342
33Abolished electroretinogram (ERG) (HP:0000550)2.54111156
34Protruding tongue (HP:0010808)2.53607584
35Increased IgM level (HP:0003496)2.48846818
36Retinal dysplasia (HP:0007973)2.46256536
37Abnormality of endocrine pancreas physiology (HP:0012093)2.44351959
38Abnormality of the pancreatic islet cells (HP:0006476)2.44351959
39Fair hair (HP:0002286)2.43943483
40Progressive inability to walk (HP:0002505)2.41156613
41Abnormal biliary tract physiology (HP:0012439)2.38792446
42Bile duct proliferation (HP:0001408)2.38792446
43Attenuation of retinal blood vessels (HP:0007843)2.38461990
44Increased CSF lactate (HP:0002490)2.35433525
45Cutaneous melanoma (HP:0012056)2.32488107
46Optic disc pallor (HP:0000543)2.29608822
47Nephrogenic diabetes insipidus (HP:0009806)2.29098866
48Type I transferrin isoform profile (HP:0003642)2.27923262
49Hyperglycemia (HP:0003074)2.24325213
50Large for gestational age (HP:0001520)2.23264583
51Cerebellar dysplasia (HP:0007033)2.20231415
52Intestinal fistula (HP:0100819)2.14658019
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11970778
54Abnormal protein N-linked glycosylation (HP:0012347)2.11970778
55Abnormal protein glycosylation (HP:0012346)2.11970778
56Abnormal glycosylation (HP:0012345)2.11970778
57Hyperinsulinemic hypoglycemia (HP:0000825)2.11347246
58Abnormality of the labia minora (HP:0012880)2.11324964
59Hamartoma of the eye (HP:0010568)2.09720952
60Widely spaced teeth (HP:0000687)2.07561504
61Vaginal fistula (HP:0004320)2.07468267
62Upper limb muscle weakness (HP:0003484)2.07029470
63Thyroiditis (HP:0100646)2.06827127
64Hypochromic microcytic anemia (HP:0004840)2.06429093
65Brushfield spots (HP:0001088)2.05737871
66Congenital sensorineural hearing impairment (HP:0008527)2.04207569
67Focal motor seizures (HP:0011153)2.00815736
68Tubulointerstitial abnormality (HP:0001969)2.00413277
69Absent speech (HP:0001344)1.99562194
70Pancytopenia (HP:0001876)1.99250347
71Bulbous nose (HP:0000414)1.98477633
72Squamous cell carcinoma (HP:0002860)1.95871508
73Hyperventilation (HP:0002883)1.95832051
74True hermaphroditism (HP:0010459)1.95456011
75Chronic hepatic failure (HP:0100626)1.94531518
76Increased corneal curvature (HP:0100692)1.93897809
77Keratoconus (HP:0000563)1.93897809
78Abnormal drinking behavior (HP:0030082)1.93511992
79Polydipsia (HP:0001959)1.93511992
80Abnormal rod and cone electroretinograms (HP:0008323)1.92452140
81Entropion (HP:0000621)1.90714413
82Respiratory failure (HP:0002878)1.88677272
83Unilateral renal agenesis (HP:0000122)1.88409646
84IgG deficiency (HP:0004315)1.86651600
85Severe muscular hypotonia (HP:0006829)1.86458169
86Congenital stationary night blindness (HP:0007642)1.86000341
87Hemiparesis (HP:0001269)1.84557779
88Congenital hepatic fibrosis (HP:0002612)1.84382434
89Methylmalonic acidemia (HP:0002912)1.84328695
90Gonadotropin excess (HP:0000837)1.83241587
91Amyotrophic lateral sclerosis (HP:0007354)1.83165118
92Hypothermia (HP:0002045)1.82714138
93Genital tract atresia (HP:0001827)1.80765429
94Vaginal atresia (HP:0000148)1.79778616
95Limb dystonia (HP:0002451)1.79071942
96Type I diabetes mellitus (HP:0100651)1.77866848
97Conjunctival hamartoma (HP:0100780)1.75749595
98Congenital, generalized hypertrichosis (HP:0004540)1.75445222
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74793985
100Cystic liver disease (HP:0006706)1.74202988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.25831077
2ADRBK23.90834828
3TAOK33.89150769
4MAP4K23.42536965
5NUAK13.24613473
6FGFR22.62086874
7VRK22.53545994
8VRK12.40815580
9DYRK22.18666883
10WNK32.09658751
11CDK192.00120203
12WNK41.82300430
13PLK31.77569507
14RPS6KA41.69650286
15MST41.65598385
16BRSK21.61566517
17TRIM281.59898836
18IKBKB1.47127124
19MAP3K131.46016903
20STK38L1.45228063
21BCKDK1.42427824
22GRK11.40884282
23TRPM71.37543764
24OXSR11.33179604
25ZAK1.31049614
26CAMKK21.30140493
27CASK1.29250414
28PINK11.28581489
29CHUK1.25865389
30CSNK1A1L1.22932067
31HIPK21.22122844
32PLK21.21049038
33MUSK1.17763194
34ERBB31.15022997
35SCYL21.12113168
36RPS6KA51.07992111
37EIF2AK31.07859908
38PHKG11.03636484
39PHKG21.03636484
40TAF11.00732863
41STK40.99823866
42MARK10.99632386
43LATS10.98353434
44PTK2B0.93245266
45CSNK1G10.92663359
46CSNK1G30.87863638
47NME20.86815676
48PRKCE0.86761267
49BMPR1B0.84428658
50CLK10.83497923
51CDK30.81924904
52TSSK60.81879792
53MAP3K120.80011599
54EPHA30.78499356
55MAP3K140.75785802
56TIE10.73183683
57TLK10.69421176
58EIF2AK10.68491998
59DAPK10.67824929
60STK30.67500495
61ITK0.66693647
62MAPK130.64762358
63PAK60.64004854
64PBK0.63376195
65BUB10.62739590
66PRKCI0.62715626
67ACVR1B0.60855453
68WNK10.60725239
69FLT30.59995606
70CSNK1G20.56716739
71CCNB10.52151104
72PAK30.51028467
73PRKCG0.50110945
74INSRR0.46631737
75CSNK1A10.46606027
76ADRBK10.43548782
77BRSK10.43347105
78NTRK20.41190070
79RAF10.39707405
80MAP3K70.39407593
81SRPK10.37140339
82FGFR30.36614484
83CAMK2D0.36264789
84ABL10.35843109
85PLK10.34675777
86PRKG20.32717666
87TNIK0.32396060
88ATM0.32187537
89PRKG10.31918526
90STK380.31079596
91NEK60.30734866
92PRKAA10.29052550
93BCR0.28942047
94CHEK20.28275474
95KDR0.28236263
96MAP2K10.28180539
97TEC0.28016661
98ERBB40.27833236
99NTRK30.25720239
100PRKAA20.25493785

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.07063723
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.03413829
3Protein export_Homo sapiens_hsa030603.00389704
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.97228529
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.93193695
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.81107717
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56837679
8Selenocompound metabolism_Homo sapiens_hsa004502.56594340
9RNA polymerase_Homo sapiens_hsa030202.55735071
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21448580
11Non-homologous end-joining_Homo sapiens_hsa034502.16834386
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07462739
13Asthma_Homo sapiens_hsa053102.02248259
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.89509754
15Butanoate metabolism_Homo sapiens_hsa006501.89292069
16Phototransduction_Homo sapiens_hsa047441.89193642
17Nitrogen metabolism_Homo sapiens_hsa009101.88165945
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.83332755
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83109930
20RNA degradation_Homo sapiens_hsa030181.82064455
21Oxidative phosphorylation_Homo sapiens_hsa001901.79985698
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.62110541
23Regulation of autophagy_Homo sapiens_hsa041401.55101481
24Ether lipid metabolism_Homo sapiens_hsa005651.47094898
25Propanoate metabolism_Homo sapiens_hsa006401.43079702
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.38775598
27Insulin secretion_Homo sapiens_hsa049111.38572271
28Parkinsons disease_Homo sapiens_hsa050121.37182607
29Peroxisome_Homo sapiens_hsa041461.36721353
30Fanconi anemia pathway_Homo sapiens_hsa034601.36013987
31Tryptophan metabolism_Homo sapiens_hsa003801.35045956
32Type I diabetes mellitus_Homo sapiens_hsa049401.32519636
33One carbon pool by folate_Homo sapiens_hsa006701.31710642
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28852344
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28831605
36Allograft rejection_Homo sapiens_hsa053301.26931630
37Systemic lupus erythematosus_Homo sapiens_hsa053221.26909238
38Autoimmune thyroid disease_Homo sapiens_hsa053201.22126513
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19030550
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16140287
41p53 signaling pathway_Homo sapiens_hsa041151.14685048
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13783653
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10570395
44Linoleic acid metabolism_Homo sapiens_hsa005911.08170800
45Pyrimidine metabolism_Homo sapiens_hsa002401.05374018
46Purine metabolism_Homo sapiens_hsa002301.05123890
47Glutathione metabolism_Homo sapiens_hsa004801.03344149
48Taste transduction_Homo sapiens_hsa047421.00996206
49Primary immunodeficiency_Homo sapiens_hsa053400.91625420
50Caffeine metabolism_Homo sapiens_hsa002320.91479427
51Salivary secretion_Homo sapiens_hsa049700.90280573
52RNA transport_Homo sapiens_hsa030130.84758098
53Graft-versus-host disease_Homo sapiens_hsa053320.80643022
54Alzheimers disease_Homo sapiens_hsa050100.79642038
55Fatty acid elongation_Homo sapiens_hsa000620.78838409
56ABC transporters_Homo sapiens_hsa020100.78175848
57Huntingtons disease_Homo sapiens_hsa050160.77930005
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77576367
59Hedgehog signaling pathway_Homo sapiens_hsa043400.75787681
60Nicotine addiction_Homo sapiens_hsa050330.75457291
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73779873
62Basal transcription factors_Homo sapiens_hsa030220.73529549
63N-Glycan biosynthesis_Homo sapiens_hsa005100.71339493
64Metabolic pathways_Homo sapiens_hsa011000.66840420
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.65847581
66Antigen processing and presentation_Homo sapiens_hsa046120.65349825
67Homologous recombination_Homo sapiens_hsa034400.61638202
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58396502
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56615044
70Collecting duct acid secretion_Homo sapiens_hsa049660.56385000
71Alcoholism_Homo sapiens_hsa050340.55661170
72Serotonergic synapse_Homo sapiens_hsa047260.54606156
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54581013
74Rheumatoid arthritis_Homo sapiens_hsa053230.52817690
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.50836887
76Chemical carcinogenesis_Homo sapiens_hsa052040.50705663
77beta-Alanine metabolism_Homo sapiens_hsa004100.48646944
78Folate biosynthesis_Homo sapiens_hsa007900.46921865
79Spliceosome_Homo sapiens_hsa030400.45931296
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43829088
81Glycerolipid metabolism_Homo sapiens_hsa005610.40618238
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40595635
83Arachidonic acid metabolism_Homo sapiens_hsa005900.38143327
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37127064
85Synaptic vesicle cycle_Homo sapiens_hsa047210.35689763
86Viral myocarditis_Homo sapiens_hsa054160.35488329
87Cardiac muscle contraction_Homo sapiens_hsa042600.34413581
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33115356
89Retinol metabolism_Homo sapiens_hsa008300.33087175
90Long-term depression_Homo sapiens_hsa047300.32281050
91Olfactory transduction_Homo sapiens_hsa047400.31636026
92Nucleotide excision repair_Homo sapiens_hsa034200.30472228
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28948709
94Circadian entrainment_Homo sapiens_hsa047130.28918228
95Mineral absorption_Homo sapiens_hsa049780.28272961
96Vitamin digestion and absorption_Homo sapiens_hsa049770.28022770
97DNA replication_Homo sapiens_hsa030300.27116990
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26667242
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25033423
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24765451

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