ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.95791622
2	ADP metabolic process (GO:0046031)	5.62180955
3	response to muscle activity (GO:0014850)	5.54254991
4	positive regulation of catecholamine secretion (GO:0033605)	5.52176786
5	histone H3-K36 demethylation (GO:0070544)	5.42677755
6	cellular response to zinc ion (GO:0071294)	5.27716018
7	TOR signaling (GO:0031929)	4.67798476
8	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.62504022
9	regulation of autophagic vacuole assembly (GO:2000785)	4.62371336
10	coenzyme catabolic process (GO:0009109)	4.60687074
11	activation of protein kinase B activity (GO:0032148)	4.59517110
12	AMP metabolic process (GO:0046033)	4.50083425
13	parturition (GO:0007567)	4.27760889
14	myofibril assembly (GO:0030239)	4.21295711
15	oligosaccharide biosynthetic process (GO:0009312)	4.12129960
16	mRNA cleavage (GO:0006379)	4.01997350
17	regulation of oxidative stress-induced neuron death (GO:1903203)	3.94815235
18	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.93861922
19	cellular response to cadmium ion (GO:0071276)	3.89831439
20	muscle cell cellular homeostasis (GO:0046716)	3.89070313
21	regulation of oxidative phosphorylation (GO:0002082)	3.79752560
22	regulation of phospholipase A2 activity (GO:0032429)	3.72748108
23	regulation of myoblast differentiation (GO:0045661)	3.67106917
24	regulation of vacuole organization (GO:0044088)	3.64694006
25	regulation of skeletal muscle contraction (GO:0014819)	3.64329553
26	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.62564043
27	positive regulation of protein kinase C signaling (GO:0090037)	3.62427473
28	energy homeostasis (GO:0097009)	3.62217696
29	negative regulation of response to reactive oxygen species (GO:1901032)	3.55042871
30	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.52842363
31	purine nucleoside diphosphate metabolic process (GO:0009135)	3.52842363
32	motile cilium assembly (GO:0044458)	3.52171783
33	cGMP-mediated signaling (GO:0019934)	3.46046378
34	regulation of ARF GTPase activity (GO:0032312)	3.45688089
35	calcium-mediated signaling using intracellular calcium source (GO:0035584)	3.45366534
36	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.37188037
37	nucleoside diphosphate biosynthetic process (GO:0009133)	3.32715298
38	muscle fiber development (GO:0048747)	3.29190479
39	ganglioside metabolic process (GO:0001573)	3.24880009
40	phagocytosis, recognition (GO:0006910)	3.15866216
41	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.08401015
42	omega-hydroxylase P450 pathway (GO:0097267)	3.07736420
43	negative regulation of defense response to virus (GO:0050687)	3.07493924
44	radial glial cell differentiation (GO:0060019)	3.07358161
45	regulation of establishment of cell polarity (GO:2000114)	3.02877145
46	oligosaccharide catabolic process (GO:0009313)	3.01993403
47	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.99881133
48	mannose metabolic process (GO:0006013)	2.97250257
49	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.96623133
50	mitochondrion degradation (GO:0000422)	2.95718171
51	diacylglycerol metabolic process (GO:0046339)	2.93898572
52	positive regulation of myoblast differentiation (GO:0045663)	2.93531915
53	cellular response to electrical stimulus (GO:0071257)	2.92583779
54	protein localization to cell surface (GO:0034394)	2.90484687
55	regulation of dopamine secretion (GO:0014059)	2.88725984
56	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.87817503
57	cytoplasmic mRNA processing body assembly (GO:0033962)	2.87792322
58	regulation of skeletal muscle fiber development (GO:0048742)	2.87146053
59	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.83874734
60	fibroblast migration (GO:0010761)	2.83677085
61	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.81738119
62	relaxation of smooth muscle (GO:0044557)	2.81316555
63	retinal cone cell development (GO:0046549)	2.80058911
64	response to zinc ion (GO:0010043)	2.79243895
65	negative regulation of macroautophagy (GO:0016242)	2.79142719
66	cellular response to lithium ion (GO:0071285)	2.77322994
67	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.75246289
68	negative regulation of smooth muscle cell proliferation (GO:0048662)	2.69043034
69	sarcomere organization (GO:0045214)	2.66515831
70	establishment of mitotic spindle orientation (GO:0000132)	2.66310674
71	cellular response to toxic substance (GO:0097237)	2.66159933
72	mesenchymal-epithelial cell signaling (GO:0060638)	2.65621190
73	cardiac muscle hypertrophy (GO:0003300)	2.63136178
74	androgen biosynthetic process (GO:0006702)	2.62264031
75	response to acidic pH (GO:0010447)	2.60834240
76	myelination in peripheral nervous system (GO:0022011)	2.58410987
77	peripheral nervous system axon ensheathment (GO:0032292)	2.58410987
78	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.57392431
79	positive regulation of protein homodimerization activity (GO:0090073)	2.53564943
80	regulation of protein kinase A signaling (GO:0010738)	2.53308392
81	tongue development (GO:0043586)	2.52891917
82	negative regulation of DNA binding (GO:0043392)	2.52626861
83	actin-mediated cell contraction (GO:0070252)	2.50005101
84	multicellular organism reproduction (GO:0032504)	2.49723311
85	regulation of protein kinase C signaling (GO:0090036)	2.47911307
86	striated muscle hypertrophy (GO:0014897)	2.47653647
87	cellular response to calcium ion (GO:0071277)	2.47002034
88	sialylation (GO:0097503)	2.46311331
89	actin-myosin filament sliding (GO:0033275)	2.45572789
90	muscle filament sliding (GO:0030049)	2.45572789
91	potassium ion export (GO:0071435)	2.44256860
92	cortical actin cytoskeleton organization (GO:0030866)	2.44228133
93	cofactor catabolic process (GO:0051187)	2.43963188
94	negative regulation of organelle assembly (GO:1902116)	2.43622775
95	regulation of gamma-delta T cell differentiation (GO:0045586)	2.42810585
96	cellular response to epinephrine stimulus (GO:0071872)	2.41431010
97	patterning of blood vessels (GO:0001569)	2.38119038
98	adaptation of signaling pathway (GO:0023058)	2.36462574
99	granulocyte differentiation (GO:0030851)	2.35708921
100	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.34780004

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.67410061
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.75026760
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.35915293
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.78303689
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.72635548
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.72449928
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.58963834
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.56611045
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.54087745
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34140707
11	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.31575612
12	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.11923148
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.04214363
14	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.95490753
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.88791363
16	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.87813301
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.71787330
18	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.68856775
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.64989883
20	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.62361755
21	VDR_22108803_ChIP-Seq_LS180_Human	1.57391893
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.52031492
23	VDR_24787735_ChIP-Seq_THP-1_Human	1.51024479
24	RXR_22108803_ChIP-Seq_LS180_Human	1.51004225
25	VDR_24763502_ChIP-Seq_THP-1_Human	1.41812001
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.40818199
27	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.40523610
28	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.35336947
29	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.31581307
30	VDR_21846776_ChIP-Seq_THP-1_Human	1.28098525
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22288832
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21657675
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21657675
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17369034
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.17369034
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14511769
37	STAT1_17558387_ChIP-Seq_HELA_Human	1.09470760
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.07649138
39	SPI1_23127762_ChIP-Seq_K562_Human	1.06883576
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06350758
41	GATA1_22025678_ChIP-Seq_K562_Human	1.05959629
42	CTCF_21964334_Chip-Seq_Bcells_Human	1.05153050
43	SPI1_20517297_ChIP-Seq_HL60_Human	1.04270141
44	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04049259
45	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.01806731
46	TBL1_22424771_ChIP-Seq_293T_Human	1.01573809
47	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.00994072
48	KDM2B_26808549_Chip-Seq_DND41_Human	1.00028112
49	ERA_21632823_ChIP-Seq_H3396_Human	0.99572202
50	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98362109
51	SMAD4_21799915_ChIP-Seq_A2780_Human	0.98095923
52	SCL_19346495_ChIP-Seq_HPC-7_Human	0.97948291
53	CTCF_27219007_Chip-Seq_Bcells_Human	0.97671218
54	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97577930
55	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.96782725
56	MAF_26560356_Chip-Seq_TH2_Human	0.96440915
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95974532
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95793659
59	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95434876
60	SMC4_20622854_ChIP-Seq_HELA_Human	0.94841556
61	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94520685
62	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93892348
63	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.93146379
64	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.92661364
65	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.91470087
66	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.91278573
67	BCAT_22108803_ChIP-Seq_LS180_Human	0.91102408
68	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91029336
69	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.90811903
70	CJUN_26792858_Chip-Seq_BT549_Human	0.90764816
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90620777
72	GATA3_27048872_Chip-Seq_THYMUS_Human	0.88283595
73	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.87106610
74	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.86407514
75	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85503071
76	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.83498569
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.82469844
78	CBP_21632823_ChIP-Seq_H3396_Human	0.81691938
79	RAC3_21632823_ChIP-Seq_H3396_Human	0.81592737
80	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.80745710
81	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.80205002
82	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.80178396
83	CDX2_22108803_ChIP-Seq_LS180_Human	0.78840141
84	LXR_22292898_ChIP-Seq_THP-1_Human	0.78097780
85	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.78009500
86	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.77719780
87	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.77719780
88	P300_19829295_ChIP-Seq_ESCs_Human	0.77458193
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.77326023
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.76460922
91	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.74749797
92	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.74136522
93	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.73877431
94	GATA3_26560356_Chip-Seq_TH2_Human	0.73857126
95	E2F1_20622854_ChIP-Seq_HELA_Human	0.73748985
96	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.73642312
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.73155862
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.72393593
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.71697554
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.71166442

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.53693633
2	MP0000749_muscle_degeneration	4.17152047
3	MP0004084_abnormal_cardiac_muscle	3.48722092
4	MP0001188_hyperpigmentation	3.23238202
5	MP0008004_abnormal_stomach_pH	3.12218073
6	MP0005409_darkened_coat_color	3.10249715
7	MP0003136_yellow_coat_color	2.95034388
8	MP0002132_abnormal_respiratory_system	2.87603886
9	MP0005647_abnormal_sex_gland	2.79510268
10	MP0002138_abnormal_hepatobiliary_system	2.71173758
11	MP0002837_dystrophic_cardiac_calcinosis	2.69657708
12	MP0005174_abnormal_tail_pigmentation	2.57819889
13	MP0010368_abnormal_lymphatic_system	2.45535358
14	MP0004036_abnormal_muscle_relaxation	2.45505482
15	MP0009697_abnormal_copulation	2.43640863
16	MP0005248_abnormal_Harderian_gland	2.39944450
17	MP0002638_abnormal_pupillary_reflex	2.38612035
18	MP0005330_cardiomyopathy	2.33491765
19	MP0004381_abnormal_hair_follicle	2.15158125
20	MP0001661_extended_life_span	2.14675674
21	MP0004484_altered_response_of	2.08546278
22	MP0009840_abnormal_foam_cell	1.98170653
23	MP0001919_abnormal_reproductive_system	1.96590120
24	MP0003315_abnormal_perineum_morphology	1.84340278
25	MP0002269_muscular_atrophy	1.80864553
26	MP0001502_abnormal_circadian_rhythm	1.70068493
27	MP0002108_abnormal_muscle_morphology	1.67856342
28	MP0000747_muscle_weakness	1.60670342
29	MP0001986_abnormal_taste_sensitivity	1.54047057
30	MP0002127_abnormal_cardiovascular_syste	1.53182412
31	MP0003828_pulmonary_edema	1.48629086
32	MP0005171_absent_coat_pigmentation	1.48040008
33	MP0001849_ear_inflammation	1.46986780
34	MP0004087_abnormal_muscle_fiber	1.46323530
35	MP0001664_abnormal_digestion	1.44586736
36	MP0003763_abnormal_thymus_physiology	1.38827872
37	MP0005187_abnormal_penis_morphology	1.33661843
38	MP0004272_abnormal_basement_membrane	1.33629492
39	MP0002160_abnormal_reproductive_system	1.33525099
40	MP0005410_abnormal_fertilization	1.33517034
41	MP0003091_abnormal_cell_migration	1.31626764
42	MP0005058_abnormal_lysosome_morphology	1.28723187
43	MP0005389_reproductive_system_phenotype	1.28636367
44	MP0000759_abnormal_skeletal_muscle	1.28212314
45	MP0000569_abnormal_digit_pigmentation	1.25663075
46	MP0000751_myopathy	1.25644450
47	MP0001905_abnormal_dopamine_level	1.25388842
48	MP0005167_abnormal_blood-brain_barrier	1.25315462
49	MP0005253_abnormal_eye_physiology	1.24846917
50	MP0005620_abnormal_muscle_contractility	1.23352076
51	MP0003632_abnormal_nervous_system	1.21194040
52	MP0003724_increased_susceptibility_to	1.19737706
53	MP0005451_abnormal_body_composition	1.18797431
54	MP0000015_abnormal_ear_pigmentation	1.18528548
55	MP0003646_muscle_fatigue	1.17896440
56	MP0004233_abnormal_muscle_weight	1.17031405
57	MP0003011_delayed_dark_adaptation	1.16916455
58	MP0002998_abnormal_bone_remodeling	1.09226472
59	MP0001270_distended_abdomen	1.08737428
60	MP0004215_abnormal_myocardial_fiber	1.06560837
61	MP0005166_decreased_susceptibility_to	1.05989485
62	MP0006082_CNS_inflammation	1.01537318
63	MP0010386_abnormal_urinary_bladder	1.00976332
64	MP0003868_abnormal_feces_composition	1.00652037
65	MP0003385_abnormal_body_wall	1.00370795
66	MP0005646_abnormal_pituitary_gland	1.00299371
67	MP0001879_abnormal_lymphatic_vessel	0.97585230
68	MP0000465_gastrointestinal_hemorrhage	0.90510301
69	MP0003879_abnormal_hair_cell	0.85670746
70	MP0001756_abnormal_urination	0.84879258
71	MP0000343_altered_response_to	0.83404234
72	MP0002877_abnormal_melanocyte_morpholog	0.82979174
73	MP0005595_abnormal_vascular_smooth	0.81514380
74	MP0005310_abnormal_salivary_gland	0.80771873
75	MP0005385_cardiovascular_system_phenoty	0.80417827
76	MP0001544_abnormal_cardiovascular_syste	0.80417827
77	MP0002139_abnormal_hepatobiliary_system	0.77256499
78	MP0002419_abnormal_innate_immunity	0.76508047
79	MP0001486_abnormal_startle_reflex	0.73679390
80	MP0003195_calcinosis	0.73284870
81	MP0009250_abnormal_appendicular_skeleto	0.73032890
82	MP0000013_abnormal_adipose_tissue	0.72311137
83	MP0010234_abnormal_vibrissa_follicle	0.71766169
84	MP0010630_abnormal_cardiac_muscle	0.70761965
85	MP0000537_abnormal_urethra_morphology	0.68750014
86	MP0000470_abnormal_stomach_morphology	0.66648381
87	MP0003631_nervous_system_phenotype	0.64561133
88	MP0000920_abnormal_myelination	0.64155831
89	MP0004130_abnormal_muscle_cell	0.63982942
90	MP0001984_abnormal_olfaction	0.63418354
91	MP0004019_abnormal_vitamin_homeostasis	0.61043345
92	MP0001835_abnormal_antigen_presentation	0.60327405
93	MP0006072_abnormal_retinal_apoptosis	0.59944053
94	MP0002115_abnormal_skeleton_extremities	0.57610951
95	MP0006036_abnormal_mitochondrial_physio	0.57331197
96	MP0005369_muscle_phenotype	0.56258023
97	MP0005551_abnormal_eye_electrophysiolog	0.55824390
98	MP0000733_abnormal_muscle_development	0.55779600
99	MP0005391_vision/eye_phenotype	0.54855214
100	MP0003656_abnormal_erythrocyte_physiolo	0.54226298

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Clumsiness (HP:0002312)	4.87108539
2	Abnormality of the columella (HP:0009929)	4.85899200
3	Hyporeflexia of lower limbs (HP:0002600)	4.70995056
4	Reduced antithrombin III activity (HP:0001976)	4.66878424
5	Difficulty running (HP:0009046)	4.54644637
6	Cerebellar dysplasia (HP:0007033)	4.37367814
7	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	4.00927629
8	Diaphragmatic weakness (HP:0009113)	3.90157630
9	Exercise-induced myalgia (HP:0003738)	3.87144525
10	Dyschromatopsia (HP:0007641)	3.80825006
11	Scapular winging (HP:0003691)	3.79139346
12	Resting tremor (HP:0002322)	3.68391149
13	Eosinophilia (HP:0001880)	3.65870888
14	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.54977059
15	Bulbar palsy (HP:0001283)	3.54551581
16	Abnormality of the shoulder girdle musculature (HP:0001435)	3.49442363
17	Aortic aneurysm (HP:0004942)	3.48750255
18	Postural instability (HP:0002172)	3.34057563
19	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.27464547
20	Facial hemangioma (HP:0000329)	3.27427876
21	Adactyly (HP:0009776)	3.21580834
22	Muscular dystrophy (HP:0003560)	3.17198086
23	Abnormality of the frontal sinuses (HP:0002687)	3.16045058
24	Choroideremia (HP:0001139)	3.15431830
25	Hepatoblastoma (HP:0002884)	3.08714409
26	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.05054614
27	Abnormality of the intrinsic pathway (HP:0010989)	3.02626637
28	Facial diplegia (HP:0001349)	2.95100697
29	Aplasia cutis congenita (HP:0001057)	2.93477526
30	Enlarged kidneys (HP:0000105)	2.86773475
31	Abnormality of liposaccharide metabolism (HP:0010968)	2.84872049
32	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.84872049
33	Abnormality of glycolipid metabolism (HP:0010969)	2.84872049
34	Granulocytopenia (HP:0001913)	2.82748000
35	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.82026523
36	Lower limb hyperreflexia (HP:0002395)	2.77815712
37	Thoracic kyphosis (HP:0002942)	2.74035954
38	Decreased central vision (HP:0007663)	2.70633286
39	Proximal amyotrophy (HP:0007126)	2.70487228
40	Spinal rigidity (HP:0003306)	2.69626627
41	Frequent falls (HP:0002359)	2.67811988
42	Hypophosphatemic rickets (HP:0004912)	2.66185312
43	EMG: myopathic abnormalities (HP:0003458)	2.66009403
44	Abnormality of the calf musculature (HP:0001430)	2.65487024
45	Popliteal pterygium (HP:0009756)	2.65238189
46	Increased variability in muscle fiber diameter (HP:0003557)	2.64199871
47	Ventricular fibrillation (HP:0001663)	2.62694562
48	Difficulty walking (HP:0002355)	2.60735573
49	Attenuation of retinal blood vessels (HP:0007843)	2.58269980
50	Abnormality of eosinophils (HP:0001879)	2.57693651
51	Short chin (HP:0000331)	2.52323123
52	Weak cry (HP:0001612)	2.49538495
53	Malignant hyperthermia (HP:0002047)	2.46452563
54	Poor head control (HP:0002421)	2.42628170
55	Abnormal protein glycosylation (HP:0012346)	2.41675695
56	Abnormal glycosylation (HP:0012345)	2.41675695
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.41675695
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.41675695
59	Partial agenesis of the corpus callosum (HP:0001338)	2.38730909
60	Calf muscle hypertrophy (HP:0008981)	2.33183675
61	Colitis (HP:0002583)	2.28915414
62	Prolonged partial thromboplastin time (HP:0003645)	2.28668225
63	Nonprogressive disorder (HP:0003680)	2.25580255
64	Alveolar cell carcinoma (HP:0006519)	2.24833885
65	Absent speech (HP:0001344)	2.22403038
66	Unsteady gait (HP:0002317)	2.17430010
67	High anterior hairline (HP:0009890)	2.17048130
68	Abnormal ciliary motility (HP:0012262)	2.13743247
69	Muscle hypertrophy of the lower extremities (HP:0008968)	2.10374019
70	Neoplasm of the tracheobronchial system (HP:0100552)	2.10294993
71	Right ventricular cardiomyopathy (HP:0011663)	2.10291321
72	Ulnar bowing (HP:0003031)	2.05676561
73	Capillary hemangiomas (HP:0005306)	2.05431265
74	Easy fatigability (HP:0003388)	2.03618331
75	Abnormality of skeletal muscle fiber size (HP:0012084)	2.01745883
76	Neck muscle weakness (HP:0000467)	1.99507734
77	Renal cortical cysts (HP:0000803)	1.99452481
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98380578
79	Foot dorsiflexor weakness (HP:0009027)	1.97582465
80	Rimmed vacuoles (HP:0003805)	1.96477709
81	Myopathic facies (HP:0002058)	1.95153988
82	Hyperkalemia (HP:0002153)	1.93070692
83	Genu recurvatum (HP:0002816)	1.91681470
84	Congenital hepatic fibrosis (HP:0002612)	1.90466381
85	Rhabdomyolysis (HP:0003201)	1.87021182
86	Sensory axonal neuropathy (HP:0003390)	1.86843581
87	Fetal akinesia sequence (HP:0001989)	1.86683417
88	Renal dysplasia (HP:0000110)	1.86179226
89	Thickened helices (HP:0000391)	1.85957639
90	Retinal atrophy (HP:0001105)	1.85694642
91	Hypoplasia of the thymus (HP:0000778)	1.85193343
92	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84067008
93	Steppage gait (HP:0003376)	1.83936382
94	Atrioventricular block (HP:0001678)	1.82741122
95	Rib fusion (HP:0000902)	1.80792373
96	Basal ganglia calcification (HP:0002135)	1.79332539
97	Narrow palate (HP:0000189)	1.78098689
98	Overgrowth (HP:0001548)	1.77746258
99	Abnormality of the thoracic spine (HP:0100711)	1.76918225
100	Turricephaly (HP:0000262)	1.76799415

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.06812909
2	MARK3	3.87994844
3	OBSCN	3.86275796
4	MAP2K7	3.78798315
5	PBK	3.77179113
6	LATS1	2.82788930
7	BLK	2.12180277
8	ADRBK2	2.11870001
9	NEK2	2.10090822
10	MAPK15	2.03504621
11	MAP3K6	1.98568771
12	MAP3K13	1.94615746
13	CSNK1A1L	1.92157619
14	CSNK1G1	1.76595286
15	MYLK	1.75282553
16	FRK	1.73159293
17	CSNK1G3	1.62182644
18	BMPR1B	1.56664024
19	TLK1	1.50467717
20	MAP3K1	1.49078560
21	NME2	1.46962720
22	SGK494	1.36367364
23	SGK223	1.36367364
24	MAP3K4	1.36218591
25	MOS	1.27232526
26	CSNK1G2	1.25993400
27	IRAK2	1.25262622
28	SGK2	1.15927677
29	MUSK	1.13196903
30	LATS2	1.12228097
31	TIE1	1.08236738
32	STK38L	1.06453648
33	EEF2K	1.06024730
34	MAPK12	1.03486556
35	PRKCQ	1.01588389
36	NLK	1.01575434
37	CDK3	1.00036105
38	MAP3K5	0.98365987
39	MELK	0.96790899
40	GRK6	0.88688319
41	ZAK	0.88198920
42	SGK3	0.88094673
43	ZAP70	0.87329854
44	RET	0.86520842
45	RPS6KB1	0.85161312
46	BTK	0.83779326
47	TGFBR1	0.75152982
48	PRKG2	0.72627597
49	PTK2B	0.72030178
50	FES	0.70839982
51	MAP3K9	0.70703821
52	ARAF	0.68427275
53	TGFBR2	0.68293018
54	STK38	0.67646075
55	TRPM7	0.59454669
56	MAP4K1	0.58732143
57	CDC42BPA	0.56292201
58	CAMK1D	0.53184978
59	CDK12	0.51411445
60	DYRK3	0.51171360
61	MAP3K10	0.51052607
62	ICK	0.50030140
63	PAK1	0.50017719
64	SYK	0.49989171
65	GRK5	0.49538310
66	RPS6KA4	0.49235259
67	PDPK1	0.48535907
68	MAP2K4	0.48185302
69	RPS6KA2	0.47077839
70	PDGFRB	0.44933299
71	FGFR2	0.44325269
72	PRKD3	0.44086070
73	CCNB1	0.42331838
74	RPS6KA5	0.42230189
75	DMPK	0.41787268
76	ROCK1	0.41372881
77	DYRK2	0.41303479
78	PKN2	0.38486097
79	CSNK1D	0.36873057
80	MTOR	0.35772802
81	GRK1	0.34601597
82	WNK1	0.34244502
83	RPS6KC1	0.31925806
84	RPS6KL1	0.31925806
85	EGFR	0.31582470
86	CAMK4	0.31418184
87	CAMK1	0.31343661
88	RPS6KA6	0.30261397
89	CSK	0.30258299
90	HCK	0.29968779
91	FGR	0.29475918
92	PHKG2	0.27953391
93	PHKG1	0.27953391
94	MAPK13	0.27326728
95	PIK3CG	0.27165098
96	ADRBK1	0.26867379
97	TRIB3	0.26372803
98	ACVR1B	0.25813674
99	PRKAA1	0.25399237
100	CSNK1A1	0.25257801

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	5.32147117
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.67550139
3	Olfactory transduction_Homo sapiens_hsa04740	2.83671553
4	Circadian rhythm_Homo sapiens_hsa04710	2.16443474
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.12233093
6	Other glycan degradation_Homo sapiens_hsa00511	2.04785605
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.80196687
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.76438546
9	Renin secretion_Homo sapiens_hsa04924	1.73156050
10	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.55810651
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.47187230
12	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.46902176
13	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.44940807
14	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43784413
15	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.42340465
16	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.35401452
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.32679546
18	Calcium signaling pathway_Homo sapiens_hsa04020	1.32595680
19	Salivary secretion_Homo sapiens_hsa04970	1.31964637
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31591757
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.29361106
22	Gap junction_Homo sapiens_hsa04540	1.16997393
23	Gastric acid secretion_Homo sapiens_hsa04971	1.15273089
24	Phototransduction_Homo sapiens_hsa04744	1.12997585
25	Regulation of autophagy_Homo sapiens_hsa04140	1.12786321
26	Circadian entrainment_Homo sapiens_hsa04713	1.11576373
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.11534566
28	Sphingolipid metabolism_Homo sapiens_hsa00600	1.08159619
29	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.06468524
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04488296
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03672804
32	Melanogenesis_Homo sapiens_hsa04916	1.01916937
33	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.01541325
34	Wnt signaling pathway_Homo sapiens_hsa04310	0.96964555
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91681953
36	Taste transduction_Homo sapiens_hsa04742	0.91162597
37	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.90722121
38	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.90389477
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.90228636
40	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.89840036
41	Sulfur relay system_Homo sapiens_hsa04122	0.89435137
42	Endometrial cancer_Homo sapiens_hsa05213	0.88332148
43	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87517080
44	Mineral absorption_Homo sapiens_hsa04978	0.87184527
45	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.86968316
46	Tuberculosis_Homo sapiens_hsa05152	0.84036776
47	Pertussis_Homo sapiens_hsa05133	0.82596880
48	Malaria_Homo sapiens_hsa05144	0.82144801
49	Platelet activation_Homo sapiens_hsa04611	0.81536272
50	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.80469569
51	FoxO signaling pathway_Homo sapiens_hsa04068	0.80372093
52	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80086314
53	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.77536018
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77032505
55	Apoptosis_Homo sapiens_hsa04210	0.75777498
56	Melanoma_Homo sapiens_hsa05218	0.72763213
57	Phagosome_Homo sapiens_hsa04145	0.72120979
58	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.70490772
59	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69731886
60	Butanoate metabolism_Homo sapiens_hsa00650	0.69186881
61	Long-term potentiation_Homo sapiens_hsa04720	0.68145072
62	Cholinergic synapse_Homo sapiens_hsa04725	0.67555373
63	Alcoholism_Homo sapiens_hsa05034	0.67457753
64	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.66089440
65	Non-small cell lung cancer_Homo sapiens_hsa05223	0.65748706
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63774157
67	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.62941721
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62784626
69	ABC transporters_Homo sapiens_hsa02010	0.61618330
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.57096715
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.56291560
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.55981329
73	ECM-receptor interaction_Homo sapiens_hsa04512	0.55786199
74	Osteoclast differentiation_Homo sapiens_hsa04380	0.54518907
75	Glioma_Homo sapiens_hsa05214	0.53727656
76	Insulin resistance_Homo sapiens_hsa04931	0.52889458
77	Prostate cancer_Homo sapiens_hsa05215	0.50647736
78	Estrogen signaling pathway_Homo sapiens_hsa04915	0.50351183
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.49804749
80	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.49680908
81	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.48585720
82	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48339364
83	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46981474
84	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.46779880
85	GnRH signaling pathway_Homo sapiens_hsa04912	0.46769307
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.46527967
87	Hepatitis B_Homo sapiens_hsa05161	0.45479715
88	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45475369
89	Focal adhesion_Homo sapiens_hsa04510	0.43612846
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43417965
91	Ras signaling pathway_Homo sapiens_hsa04014	0.42897073
92	Hepatitis C_Homo sapiens_hsa05160	0.42789366
93	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.42297222
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41906583
95	Rap1 signaling pathway_Homo sapiens_hsa04015	0.39731201
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39467631
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38396630
98	Insulin signaling pathway_Homo sapiens_hsa04910	0.38168528
99	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37155414
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.36157357

GPR79

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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