GPR82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation via MHC class Ib (GO:0002475)9.96204641
2positive regulation of antigen processing and presentation (GO:0002579)7.84571098
3regulation of antigen processing and presentation (GO:0002577)6.62239976
4behavioral response to nicotine (GO:0035095)5.84531054
5fucose catabolic process (GO:0019317)4.87294875
6L-fucose metabolic process (GO:0042354)4.87294875
7L-fucose catabolic process (GO:0042355)4.87294875
8negative regulation of cell killing (GO:0031342)4.83114806
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.83114806
10response to pheromone (GO:0019236)4.49765793
11regulation of memory T cell differentiation (GO:0043380)4.38071932
12monocyte chemotaxis (GO:0002548)4.34903574
13regulation of acrosome reaction (GO:0060046)4.12300773
14eosinophil chemotaxis (GO:0048245)4.09228590
15fusion of sperm to egg plasma membrane (GO:0007342)4.06782646
16response to muramyl dipeptide (GO:0032495)4.00416082
17negative regulation of cAMP-mediated signaling (GO:0043951)4.00292742
18production of molecular mediator involved in inflammatory response (GO:0002532)3.99102241
19protein polyglutamylation (GO:0018095)3.91722381
20DNA deamination (GO:0045006)3.78806721
21regulation of pigment cell differentiation (GO:0050932)3.77394767
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73989364
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.73989364
24modulation by symbiont of host immune response (GO:0052553)3.73989364
25positive regulation by symbiont of host defense response (GO:0052509)3.73989364
26modulation by symbiont of host defense response (GO:0052031)3.73989364
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73989364
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66468042
29cyclooxygenase pathway (GO:0019371)3.63417257
30negative regulation of mast cell activation (GO:0033004)3.60115352
31detection of light stimulus involved in sensory perception (GO:0050962)3.56631909
32detection of light stimulus involved in visual perception (GO:0050908)3.56631909
33positive regulation of defense response to virus by host (GO:0002230)3.56445757
34eosinophil migration (GO:0072677)3.55964069
35purinergic nucleotide receptor signaling pathway (GO:0035590)3.55412644
36G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.54377710
37regulation of cilium movement (GO:0003352)3.53686239
38kynurenine metabolic process (GO:0070189)3.51114315
39nonmotile primary cilium assembly (GO:0035058)3.46526439
40indole-containing compound catabolic process (GO:0042436)3.44324840
41indolalkylamine catabolic process (GO:0046218)3.44324840
42tryptophan catabolic process (GO:0006569)3.44324840
43neutrophil activation involved in immune response (GO:0002283)3.43741736
44indolalkylamine metabolic process (GO:0006586)3.41329748
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39743428
46phagocytosis, engulfment (GO:0006911)3.36788751
47epithelial cell differentiation involved in kidney development (GO:0035850)3.34338703
48respiratory burst (GO:0045730)3.33812009
49opioid receptor signaling pathway (GO:0038003)3.31211748
50positive regulation of B cell differentiation (GO:0045579)3.29738405
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27729917
52axoneme assembly (GO:0035082)3.26196360
53negative regulation of granulocyte differentiation (GO:0030853)3.23071062
54neural tube formation (GO:0001841)3.17261385
55epithelial cilium movement (GO:0003351)3.13802587
56cellular ketone body metabolic process (GO:0046950)3.12737897
57neutrophil activation (GO:0042119)3.12728691
58water-soluble vitamin biosynthetic process (GO:0042364)3.10202272
59cellular extravasation (GO:0045123)3.09377417
60regulation of action potential (GO:0098900)3.09259889
61G-protein coupled receptor internalization (GO:0002031)3.07748906
62lipoxygenase pathway (GO:0019372)3.07480138
63pyrimidine nucleobase catabolic process (GO:0006208)3.06607485
64rRNA catabolic process (GO:0016075)3.05842250
65positive regulation of cAMP-mediated signaling (GO:0043950)3.01107097
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99830006
67regulation of B cell differentiation (GO:0045577)2.98905966
68multicellular organism reproduction (GO:0032504)2.98861773
69melanocyte differentiation (GO:0030318)2.97612124
70regulation of T-helper 2 cell differentiation (GO:0045628)2.97302552
71cilium morphogenesis (GO:0060271)2.94924767
72granulocyte activation (GO:0036230)2.94666133
73prostanoid metabolic process (GO:0006692)2.93950066
74prostaglandin metabolic process (GO:0006693)2.93950066
75platelet dense granule organization (GO:0060155)2.92828974
76positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92624668
77positive regulation of cellular amide metabolic process (GO:0034250)2.92440076
78plasma membrane fusion (GO:0045026)2.89859820
79regulation of B cell receptor signaling pathway (GO:0050855)2.89014214
80regulation of T-helper 1 cell differentiation (GO:0045625)2.86970970
81purinergic receptor signaling pathway (GO:0035587)2.86915657
82preassembly of GPI anchor in ER membrane (GO:0016254)2.86336853
83piRNA metabolic process (GO:0034587)2.85686450
84kidney morphogenesis (GO:0060993)2.85626546
85retinal cone cell development (GO:0046549)2.85019835
86regulation of clathrin-mediated endocytosis (GO:2000369)2.84606794
87regulation of mesoderm development (GO:2000380)2.84596825
88tryptophan metabolic process (GO:0006568)2.82271449
89response to peptidoglycan (GO:0032494)2.81158069
90ketone body metabolic process (GO:1902224)2.78940591
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78863085
92nucleobase catabolic process (GO:0046113)2.78035008
93protein localization to cilium (GO:0061512)2.77805833
94regulation of hexokinase activity (GO:1903299)2.76808450
95regulation of glucokinase activity (GO:0033131)2.76808450
96negative regulation of receptor-mediated endocytosis (GO:0048261)2.76250074
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74308627
98neuronal action potential (GO:0019228)2.72439354
99regulation of microtubule-based movement (GO:0060632)2.72356513
100protein complex biogenesis (GO:0070271)2.72156556
101gamma-aminobutyric acid transport (GO:0015812)2.71859483
102cellular biogenic amine catabolic process (GO:0042402)2.70431008
103amine catabolic process (GO:0009310)2.70431008
104regulation of T cell tolerance induction (GO:0002664)2.70209680
105respiratory chain complex IV assembly (GO:0008535)2.70142774
106negative regulation of telomere maintenance (GO:0032205)2.69776401
107photoreceptor cell maintenance (GO:0045494)2.69590484
108reciprocal DNA recombination (GO:0035825)2.68561858
109reciprocal meiotic recombination (GO:0007131)2.68561858
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68504223
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.68504223
112NADH dehydrogenase complex assembly (GO:0010257)2.68504223
113behavioral response to ethanol (GO:0048149)2.67353467
114complement activation, alternative pathway (GO:0006957)2.66327887
115macrophage activation involved in immune response (GO:0002281)2.65977570
116response to host immune response (GO:0052572)2.65170180
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65170180
118protein K11-linked deubiquitination (GO:0035871)2.63401794
119exogenous drug catabolic process (GO:0042738)2.63267504
120positive regulation of cell fate commitment (GO:0010455)2.62558762
121regulation of tolerance induction (GO:0002643)2.61254175
122tolerance induction (GO:0002507)2.61055624
123positive regulation of gamma-delta T cell activation (GO:0046645)2.60321766
124positive regulation of type 2 immune response (GO:0002830)2.59896239
125ubiquinone biosynthetic process (GO:0006744)2.59124811
126pigment cell differentiation (GO:0050931)2.59080307
127synaptic transmission, cholinergic (GO:0007271)2.58956570
128positive regulation of T-helper 1 type immune response (GO:0002827)2.58386351
129indole-containing compound metabolic process (GO:0042430)2.58219400
130positive thymic T cell selection (GO:0045059)2.57684357
131protein-cofactor linkage (GO:0018065)2.57623762
132cellular response to zinc ion (GO:0071294)2.57188779
133microglial cell activation (GO:0001774)2.56715376
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.56520535
135positive regulation of monocyte chemotaxis (GO:0090026)2.56331164
136drug catabolic process (GO:0042737)2.56215560
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.55193168
138regulation of translation, ncRNA-mediated (GO:0045974)2.55193168
139negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55193168
140G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.54329436
141replication fork processing (GO:0031297)2.53735863
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52936846
143sulfation (GO:0051923)2.52112320
144histone H3-K4 trimethylation (GO:0080182)2.51716789
145oxidative demethylation (GO:0070989)2.51706359
146cilium movement (GO:0003341)2.51656190
147negative regulation of type 2 immune response (GO:0002829)2.50800270
148positive regulation of prostaglandin secretion (GO:0032308)2.50558334
149phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48491688
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48218687
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47814922
152cornea development in camera-type eye (GO:0061303)2.46143638
153positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.45532494
154fucosylation (GO:0036065)2.44971145
155mitochondrial respiratory chain complex assembly (GO:0033108)2.44841974
156regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.43544172
157positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.42869120
158cilium organization (GO:0044782)2.42828752
159reflex (GO:0060004)2.42580962
160S-adenosylmethionine metabolic process (GO:0046500)2.41794197
161regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41700817
162meiotic chromosome segregation (GO:0045132)2.41657802
163transmission of nerve impulse (GO:0019226)2.41565441
164positive regulation of fatty acid transport (GO:2000193)2.40255504
165thyroid hormone metabolic process (GO:0042403)2.40150415
166adaptation of signaling pathway (GO:0023058)2.39893534
167photoreceptor cell development (GO:0042461)2.38843174
168negative regulation of interleukin-12 production (GO:0032695)2.37951804
169ncRNA catabolic process (GO:0034661)2.37871539
170membrane invagination (GO:0010324)2.37233277
171regulation of type 2 immune response (GO:0002828)2.36099136
172regulation of hydrogen peroxide metabolic process (GO:0010310)2.36083417
173linoleic acid metabolic process (GO:0043651)2.32894326
174myeloid dendritic cell differentiation (GO:0043011)2.32453011
175glycerophospholipid catabolic process (GO:0046475)2.32265525
176positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.31709656
177positive regulation of interleukin-12 production (GO:0032735)2.29181897
178regulation of Cdc42 GTPase activity (GO:0043088)2.28495061
179positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27727194
180positive regulation of response to biotic stimulus (GO:0002833)2.27623678
181arachidonic acid metabolic process (GO:0019369)2.27393216
182cerebral cortex radially oriented cell migration (GO:0021799)2.26081943
183regulation of interleukin-12 biosynthetic process (GO:0045075)2.25783748
184neuroepithelial cell differentiation (GO:0060563)2.25379582
185myeloid leukocyte migration (GO:0097529)2.25322884
186T cell homeostasis (GO:0043029)2.22310374
187GPI anchor metabolic process (GO:0006505)2.22294958
188macrophage chemotaxis (GO:0048246)2.22070161
189synaptic vesicle docking involved in exocytosis (GO:0016081)2.21964617
190positive regulation of response to oxidative stress (GO:1902884)2.21342160
191positive regulation of cellular response to oxidative stress (GO:1900409)2.21342160
192positive regulation of lymphocyte migration (GO:2000403)2.20982677
193regulation of granulocyte differentiation (GO:0030852)2.19950166
194positive T cell selection (GO:0043368)2.19723325
195antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)11.7153974
196antigen processing and presentation of endogenous peptide antigen (GO:0002483)11.7153974
197antigen processing and presentation of endogenous antigen (GO:0019883)11.5784487
198regulation of antigen processing and presentation of peptide antigen (GO:0002583)11.1373514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.21788310
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.85453479
3EZH2_22144423_ChIP-Seq_EOC_Human4.72184285
4ZNF274_21170338_ChIP-Seq_K562_Hela3.82196754
5IGF1R_20145208_ChIP-Seq_DFB_Human3.42406099
6VDR_22108803_ChIP-Seq_LS180_Human3.31494599
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.85291570
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.61828879
9AR_21572438_ChIP-Seq_LNCaP_Human2.51934639
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49675357
11GBX2_23144817_ChIP-Seq_PC3_Human2.34644220
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.31361517
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16302610
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09072112
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.08900138
16* EWS_26573619_Chip-Seq_HEK293_Human2.06128344
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99696681
18ER_23166858_ChIP-Seq_MCF-7_Human1.95085046
19TAF15_26573619_Chip-Seq_HEK293_Human1.95059033
20FUS_26573619_Chip-Seq_HEK293_Human1.94474219
21IRF1_19129219_ChIP-ChIP_H3396_Human1.91746428
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78418284
23DROSHA_22980978_ChIP-Seq_HELA_Human1.76970970
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76804804
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76605432
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76484981
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74490374
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73402853
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72134078
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71350402
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.64998959
32BCAT_22108803_ChIP-Seq_LS180_Human1.62843831
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.62391144
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62280633
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56507480
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55081431
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.54684564
38TP53_22573176_ChIP-Seq_HFKS_Human1.50969839
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49459950
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49451281
41AHR_22903824_ChIP-Seq_MCF-7_Human1.49183433
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48750565
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44499966
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43749719
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.43629496
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42806698
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42806698
48SMAD4_21799915_ChIP-Seq_A2780_Human1.41169818
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41147831
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40715117
51NANOG_19829295_ChIP-Seq_ESCs_Human1.40106229
52SOX2_19829295_ChIP-Seq_ESCs_Human1.40106229
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40000009
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39729160
55AR_25329375_ChIP-Seq_VCAP_Human1.39466446
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37618319
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37471779
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.37034708
59CBP_20019798_ChIP-Seq_JUKART_Human1.36082231
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36082231
61TCF4_22108803_ChIP-Seq_LS180_Human1.36051049
62REST_21632747_ChIP-Seq_MESCs_Mouse1.34974591
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34469082
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33885915
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33529628
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.32929328
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32929328
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32596113
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.32492641
70VDR_24787735_ChIP-Seq_THP-1_Human1.32079252
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31013949
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28338067
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27049739
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26641701
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25462332
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25462332
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25049944
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24649612
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.24233551
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24083820
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23243553
82TP53_18474530_ChIP-ChIP_U2OS_Human1.23200744
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.22995754
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22927709
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22909813
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.22853193
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22767537
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.22351300
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21788172
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21495831
91RNF2_27304074_Chip-Seq_NSC_Mouse1.20199778
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19753108
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.19559961
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18650745
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18038832
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17916421
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.17387289
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17014826
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16472035
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15940109
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.15697627
102MYC_18940864_ChIP-ChIP_HL60_Human1.15085512
103HOXB7_26014856_ChIP-Seq_BT474_Human1.15067738
104P300_19829295_ChIP-Seq_ESCs_Human1.15063869
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14315596
106TP53_16413492_ChIP-PET_HCT116_Human1.14031474
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12812495
108SCL_19346495_ChIP-Seq_HPC-7_Human1.12097209
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10167505
110AR_20517297_ChIP-Seq_VCAP_Human1.10041504
111NCOR_22424771_ChIP-Seq_293T_Human1.10024862
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.09160356
113TCF4_23295773_ChIP-Seq_U87_Human1.09033935
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.07479124
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.07263903
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06993363
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06405550
118CDX2_22108803_ChIP-Seq_LS180_Human1.05622223
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05516483
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.05186909
121GABP_17652178_ChIP-ChIP_JURKAT_Human1.02454312
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.01775464
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01451489
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00264092
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.00196962
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99792451
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99393666
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98849242
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98715043
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98028675
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.97863546
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97500943
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97317342
134STAT3_23295773_ChIP-Seq_U87_Human0.97163826
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96173431
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.96120899
137GATA3_26560356_Chip-Seq_TH2_Human0.95957577
138SPI1_23127762_ChIP-Seq_K562_Human0.94865234
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94648957
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94129748
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93365715
142* RUNX2_22187159_ChIP-Seq_PCA_Human0.93260219
143KDM2B_26808549_Chip-Seq_REH_Human0.93188549
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.92974567
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92446547
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92126127
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.91806250
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.89097219
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89028991
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88497794
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88137098
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87029350
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.86427647
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.86240595
155P53_22387025_ChIP-Seq_ESCs_Mouse0.86226641
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.85916486
157NMYC_18555785_Chip-Seq_ESCs_Mouse0.85627151
158RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85197991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.40035630
2MP0001835_abnormal_antigen_presentation3.96350349
3MP0003303_peritoneal_inflammation3.68686951
4MP0003195_calcinosis3.65279513
5MP0005174_abnormal_tail_pigmentation3.02315464
6MP0005058_abnormal_lysosome_morphology2.89772985
7MP0002148_abnormal_hypersensitivity_rea2.74928024
8MP0008877_abnormal_DNA_methylation2.53689455
9MP0003436_decreased_susceptibility_to2.52725839
10MP0005551_abnormal_eye_electrophysiolog2.48232562
11MP0002254_reproductive_system_inflammat2.43225969
12MP0002419_abnormal_innate_immunity2.39158546
13MP0000015_abnormal_ear_pigmentation2.29965880
14MP0001790_abnormal_immune_system2.29722835
15MP0005387_immune_system_phenotype2.29722835
16MP0004510_myositis2.26810754
17MP0002102_abnormal_ear_morphology2.21147869
18MP0005257_abnormal_intraocular_pressure2.20512777
19MP0008004_abnormal_stomach_pH2.19711934
20MP0002653_abnormal_ependyma_morphology2.19559264
21MP0003300_gastrointestinal_ulcer2.17956633
22MP0003880_abnormal_central_pattern2.17799684
23MP0008872_abnormal_physiological_respon2.17637672
24MP0001968_abnormal_touch/_nociception2.08998676
25MP0005464_abnormal_platelet_physiology2.05951017
26MP0002837_dystrophic_cardiac_calcinosis2.04595431
27MP0000685_abnormal_immune_system2.03046090
28MP0008875_abnormal_xenobiotic_pharmacok2.02405318
29MP0004043_abnormal_pH_regulation2.01802633
30MP0005671_abnormal_response_to1.94682311
31MP0003646_muscle_fatigue1.91449708
32MP0001986_abnormal_taste_sensitivity1.88548127
33MP0003136_yellow_coat_color1.87136921
34MP0006072_abnormal_retinal_apoptosis1.82672377
35MP0000372_irregular_coat_pigmentation1.77450284
36MP0001485_abnormal_pinna_reflex1.75371766
37MP0003172_abnormal_lysosome_physiology1.74970838
38MP0002452_abnormal_antigen_presenting1.74892785
39MP0005409_darkened_coat_color1.73552713
40MP0005000_abnormal_immune_tolerance1.73276831
41MP0001800_abnormal_humoral_immune1.73126021
42MP0001853_heart_inflammation1.70220074
43MP0005253_abnormal_eye_physiology1.66952917
44MP0002938_white_spotting1.66240240
45MP0005025_abnormal_response_to1.65248287
46MP0002272_abnormal_nervous_system1.64951022
47MP0002723_abnormal_immune_serum1.62643412
48MP0006292_abnormal_olfactory_placode1.59623366
49MP0005645_abnormal_hypothalamus_physiol1.57697013
50MP0000371_diluted_coat_color1.57659017
51MP0003866_abnormal_defecation1.53126652
52MP0006276_abnormal_autonomic_nervous1.50914153
53MP0001533_abnormal_skeleton_physiology1.50612428
54MP0001819_abnormal_immune_cell1.50315586
55MP0005310_abnormal_salivary_gland1.50199714
56MP0008874_decreased_physiological_sensi1.47037502
57MP0002420_abnormal_adaptive_immunity1.46451804
58MP0002138_abnormal_hepatobiliary_system1.46029860
59MP0009785_altered_susceptibility_to1.44964398
60MP0002163_abnormal_gland_morphology1.43689573
61MP0005075_abnormal_melanosome_morpholog1.41625217
62MP0005646_abnormal_pituitary_gland1.41055945
63MP0003724_increased_susceptibility_to1.40600780
64MP0002876_abnormal_thyroid_physiology1.40142585
65MP0009046_muscle_twitch1.40005535
66MP0003183_abnormal_peptide_metabolism1.39595335
67MP0002736_abnormal_nociception_after1.39049938
68MP0009379_abnormal_foot_pigmentation1.38356539
69MP0001501_abnormal_sleep_pattern1.37833961
70MP0002095_abnormal_skin_pigmentation1.33562076
71MP0004133_heterotaxia1.32728798
72MP0005451_abnormal_body_composition1.32622434
73MP0004264_abnormal_extraembryonic_tissu1.32281675
74MP0003787_abnormal_imprinting1.31584391
75MP0002998_abnormal_bone_remodeling1.30799943
76MP0005084_abnormal_gallbladder_morpholo1.30724726
77MP0005167_abnormal_blood-brain_barrier1.29645864
78MP0003011_delayed_dark_adaptation1.29263755
79MP0002075_abnormal_coat/hair_pigmentati1.28907376
80MP0000566_synostosis1.27256983
81MP0002557_abnormal_social/conspecific_i1.24409494
82MP0002638_abnormal_pupillary_reflex1.24302924
83MP0001186_pigmentation_phenotype1.21909913
84MP0001299_abnormal_eye_distance/1.21672183
85MP0001529_abnormal_vocalization1.20909769
86MP0003045_fibrosis1.20741155
87MP0004742_abnormal_vestibular_system1.18759308
88MP0003075_altered_response_to1.17918368
89MP0004924_abnormal_behavior1.17908651
90MP0005386_behavior/neurological_phenoty1.17908651
91MP0001984_abnormal_olfaction1.16995440
92MP0008775_abnormal_heart_ventricle1.16910190
93MP0001440_abnormal_grooming_behavior1.16262028
94MP0002735_abnormal_chemical_nociception1.14833989
95MP0001188_hyperpigmentation1.14154583
96MP0005171_absent_coat_pigmentation1.13763031
97MP0003252_abnormal_bile_duct1.11690359
98MP0003121_genomic_imprinting1.10272680
99MP0010386_abnormal_urinary_bladder1.10012122
100MP0000631_abnormal_neuroendocrine_gland1.08792584
101MP0002063_abnormal_learning/memory/cond1.05311235
102MP0009763_increased_sensitivity_to1.05129594
103MP0005365_abnormal_bile_salt1.04276497
104MP0002733_abnormal_thermal_nociception1.04137957
105MP0002405_respiratory_system_inflammati1.04005071
106MP0001845_abnormal_inflammatory_respons1.03406343
107MP0005423_abnormal_somatic_nervous1.02754534
108MP0005379_endocrine/exocrine_gland_phen1.02588609
109MP0004145_abnormal_muscle_electrophysio1.02493638
110MP0005389_reproductive_system_phenotype1.01797267
111MP0002928_abnormal_bile_duct1.01464709
112MP0009764_decreased_sensitivity_to1.00471006
113MP0005195_abnormal_posterior_eye0.99232566
114MP0005377_hearing/vestibular/ear_phenot0.99205975
115MP0003878_abnormal_ear_physiology0.99205975
116MP0005410_abnormal_fertilization0.98847273
117MP0004142_abnormal_muscle_tone0.93785667
118MP0000230_abnormal_systemic_arterial0.93534044
119MP0001905_abnormal_dopamine_level0.93189071
120MP0001919_abnormal_reproductive_system0.93074204
121MP0001486_abnormal_startle_reflex0.92960407
122MP0001502_abnormal_circadian_rhythm0.91439118
123MP0002295_abnormal_pulmonary_circulatio0.89830519
124MP0000778_abnormal_nervous_system0.88183138
125MP0002277_abnormal_respiratory_mucosa0.87717576
126MP0009745_abnormal_behavioral_response0.86917048
127MP0002752_abnormal_somatic_nervous0.86652357
128MP0000343_altered_response_to0.85566750
129MP0000716_abnormal_immune_system0.85423322
130MP0008961_abnormal_basal_metabolism0.84905683
131MP0004134_abnormal_chest_morphology0.84271644
132MP0005085_abnormal_gallbladder_physiolo0.84137827
133MP0002396_abnormal_hematopoietic_system0.84135313
134MP0003938_abnormal_ear_development0.83103336
135MP0004147_increased_porphyrin_level0.82687009
136MP0010329_abnormal_lipoprotein_level0.82101309
137MP0003890_abnormal_embryonic-extraembry0.81890836
138MP0001873_stomach_inflammation0.81759196
139MP0000026_abnormal_inner_ear0.81725680
140MP0002160_abnormal_reproductive_system0.81695062
141MP0004885_abnormal_endolymph0.80923858
142MP0008469_abnormal_protein_level0.80886916
143MP0003091_abnormal_cell_migration0.80392472
144MP0002229_neurodegeneration0.79625133
145MP0002751_abnormal_autonomic_nervous0.78637702
146MP0005390_skeleton_phenotype0.78606928
147MP0001177_atelectasis0.78306348
148MP0002572_abnormal_emotion/affect_behav0.77635627
149MP0004859_abnormal_synaptic_plasticity0.77406363
150MP0004215_abnormal_myocardial_fiber0.77163468
151MP0000579_abnormal_nail_morphology0.76929278
152MP0003638_abnormal_response/metabolism_0.76623506
153MP0010155_abnormal_intestine_physiology0.76483340
154MP0002234_abnormal_pharynx_morphology0.74776430
155MP0002064_seizures0.73020849
156MP0003690_abnormal_glial_cell0.72978478
157MP0009333_abnormal_splenocyte_physiolog0.72561740
158MP0003828_pulmonary_edema0.69248558
159MP0000383_abnormal_hair_follicle0.68733697
160MP0003635_abnormal_synaptic_transmissio0.68551921
161MP0001970_abnormal_pain_threshold0.68393284
162MP0004858_abnormal_nervous_system0.66734607
163MP0002398_abnormal_bone_marrow0.66445165
164MP0000427_abnormal_hair_cycle0.66094754
165MP0002933_joint_inflammation0.65542146
166MP0001963_abnormal_hearing_physiology0.65423324
167MP0000920_abnormal_myelination0.64829485
168MP0002067_abnormal_sensory_capabilities0.64776427

Predicted human phenotypes

RankGene SetZ-score
1Generalized hypopigmentation of hair (HP:0011358)5.55290489
2Recurrent gram-negative bacterial infections (HP:0005420)5.16835069
3Duplicated collecting system (HP:0000081)4.61903376
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.51791912
5Pancreatic cysts (HP:0001737)4.45516333
6Congenital stationary night blindness (HP:0007642)4.16072328
7Abnormality of the renal collecting system (HP:0004742)4.11824735
8Abnormality of midbrain morphology (HP:0002418)4.07245214
9Molar tooth sign on MRI (HP:0002419)4.07245214
10Panhypogammaglobulinemia (HP:0003139)4.05788131
11Chromsome breakage (HP:0040012)4.02149760
12Pancreatic fibrosis (HP:0100732)3.85922796
13Recurrent abscess formation (HP:0002722)3.80021079
14Thyroid-stimulating hormone excess (HP:0002925)3.70013327
15True hermaphroditism (HP:0010459)3.66772032
16Chronic mucocutaneous candidiasis (HP:0002728)3.65261569
17Recurrent cutaneous fungal infections (HP:0011370)3.65261569
18Recurrent bacterial skin infections (HP:0005406)3.58234289
19Colitis (HP:0002583)3.47592007
20Generalized hypopigmentation (HP:0007513)3.47293236
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.41768714
22Vacuolated lymphocytes (HP:0001922)3.41695225
23Nephronophthisis (HP:0000090)3.40646216
24Abnormality of the renal cortex (HP:0011035)3.34859439
25Eczematoid dermatitis (HP:0000976)3.32312743
26Ocular albinism (HP:0001107)3.30462510
27Gingivitis (HP:0000230)3.19371776
28Myocardial infarction (HP:0001658)3.16693255
29Abolished electroretinogram (ERG) (HP:0000550)3.12897305
30Abnormality of the renal medulla (HP:0100957)3.04844671
31Chronic obstructive pulmonary disease (HP:0006510)3.01697798
32Obstructive lung disease (HP:0006536)3.01697798
33Recurrent skin infections (HP:0001581)3.01587596
34Periodontitis (HP:0000704)2.99113763
35Recurrent viral infections (HP:0004429)2.98058350
36Attenuation of retinal blood vessels (HP:0007843)2.95540803
37Choroideremia (HP:0001139)2.94040628
38Progressive inability to walk (HP:0002505)2.93712132
39Tinnitus (HP:0000360)2.92938012
40Iris hypopigmentation (HP:0007730)2.90291272
41Recurrent fungal infections (HP:0002841)2.89095881
42Medial flaring of the eyebrow (HP:0010747)2.88397264
43Tubular atrophy (HP:0000092)2.86387405
44Chronic otitis media (HP:0000389)2.86001893
45Inflammation of the large intestine (HP:0002037)2.84733301
46Type II lissencephaly (HP:0007260)2.83483082
47Abnormality of alanine metabolism (HP:0010916)2.79925820
48Hyperalaninemia (HP:0003348)2.79925820
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79925820
50Agammaglobulinemia (HP:0004432)2.74059052
51Loss of speech (HP:0002371)2.69290747
52Abnormality of DNA repair (HP:0003254)2.68658435
53Inability to walk (HP:0002540)2.68491000
54Abnormality of complement system (HP:0005339)2.67459881
55Tubulointerstitial fibrosis (HP:0005576)2.66409951
56Progressive visual loss (HP:0000529)2.65577958
57Cystic liver disease (HP:0006706)2.64393865
58Abnormal rod and cone electroretinograms (HP:0008323)2.62997410
59Mediastinal lymphadenopathy (HP:0100721)2.62994261
60Abnormal drinking behavior (HP:0030082)2.62218152
61Polydipsia (HP:0001959)2.62218152
62Complement deficiency (HP:0004431)2.61999444
63Chronic hepatic failure (HP:0100626)2.61077901
64Bilateral sensorineural hearing impairment (HP:0008619)2.56794226
65Optic neuritis (HP:0100653)2.54865418
66Retrobulbar optic neuritis (HP:0100654)2.54865418
67Abnormality of macrophages (HP:0004311)2.54838213
68Obstructive sleep apnea (HP:0002870)2.49757015
69Pendular nystagmus (HP:0012043)2.41229381
70Abnormality of the fovea (HP:0000493)2.39338002
71Decreased circulating renin level (HP:0003351)2.37309045
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.35024744
73Renal cortical cysts (HP:0000803)2.33744592
74Increased corneal curvature (HP:0100692)2.33219772
75Keratoconus (HP:0000563)2.33219772
76Viral hepatitis (HP:0006562)2.31253122
77J-shaped sella turcica (HP:0002680)2.30700979
78Abnormality of small intestinal villus morphology (HP:0011472)2.29206916
79Villous atrophy (HP:0011473)2.29206916
80Sclerocornea (HP:0000647)2.28957124
81Febrile seizures (HP:0002373)2.28624767
82Gastrointestinal inflammation (HP:0004386)2.28380999
83Broad-based gait (HP:0002136)2.28192385
84Reticulocytopenia (HP:0001896)2.27729205
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.25693978
86Abnormality of glycolipid metabolism (HP:0010969)2.25693978
87Abnormality of liposaccharide metabolism (HP:0010968)2.25693978
88Gaze-evoked nystagmus (HP:0000640)2.25531727
89Glomerulonephritis (HP:0000099)2.23660985
903-Methylglutaconic aciduria (HP:0003535)2.22831849
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21872733
92Lissencephaly (HP:0001339)2.21779810
93Large for gestational age (HP:0001520)2.21660345
94Dysostosis multiplex (HP:0000943)2.21130662
95Polyuria (HP:0000103)2.18570427
96Hydroxyprolinuria (HP:0003080)2.16418686
97Abnormality of proline metabolism (HP:0010907)2.16418686
98Gait imbalance (HP:0002141)2.14977198
99Congenital hepatic fibrosis (HP:0002612)2.14816751
100Anencephaly (HP:0002323)2.14011026
101Increased cerebral lipofuscin (HP:0011813)2.12506736
102Joint hemorrhage (HP:0005261)2.10747476
103Systemic lupus erythematosus (HP:0002725)2.10640932
104Hypoplasia of the fovea (HP:0007750)2.09806582
105Aplasia/Hypoplasia of the fovea (HP:0008060)2.09806582
106Intestinal atresia (HP:0011100)2.09492916
107Congenital, generalized hypertrichosis (HP:0004540)2.09156802
108Congenital primary aphakia (HP:0007707)2.08851596
109Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07595166
110Aplasia/Hypoplasia of the tibia (HP:0005772)2.05036237
111Retinal atrophy (HP:0001105)2.04849162
112Abnormality of polysaccharide metabolism (HP:0011012)2.03770387
113Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03770387
114Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03770387
115Clumsiness (HP:0002312)2.01938736
116Cerebellar dysplasia (HP:0007033)2.01214093
117Acrocyanosis (HP:0001063)2.01083387
118Nephrogenic diabetes insipidus (HP:0009806)2.00512638
119Bony spicule pigmentary retinopathy (HP:0007737)2.00078947
120Progressive cerebellar ataxia (HP:0002073)1.99893959
121Decreased central vision (HP:0007663)1.99358821
122Pachygyria (HP:0001302)1.99193898
123White forelock (HP:0002211)1.98751164
124Keratoconjunctivitis (HP:0001096)1.98333192
125Cheilitis (HP:0100825)1.98100746
126Gingival bleeding (HP:0000225)1.98037224
127Hyperphosphatemia (HP:0002905)1.97621575
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.97115581
129Facial diplegia (HP:0001349)1.96125643
130Orchitis (HP:0100796)1.95831779
131Bile duct proliferation (HP:0001408)1.94548905
132Abnormal biliary tract physiology (HP:0012439)1.94548905
133Concave nail (HP:0001598)1.93792576
134Duplication of thumb phalanx (HP:0009942)1.92915830
135Distal lower limb muscle weakness (HP:0009053)1.92616027
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91744141
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.91272324
138Absent/shortened dynein arms (HP:0200106)1.91272324
139Absent frontal sinuses (HP:0002688)1.91069572
140Stomach cancer (HP:0012126)1.89328116
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.88311296
142Absent speech (HP:0001344)1.87136340
143Amyloidosis (HP:0011034)1.87094798
144Parakeratosis (HP:0001036)1.85024819
145Optic disc pallor (HP:0000543)1.84555313
146Agnosia (HP:0010524)1.84320913
147Prolonged bleeding time (HP:0003010)1.84022585
148Male pseudohermaphroditism (HP:0000037)1.83204371
149Chorioretinal atrophy (HP:0000533)1.82284596
150Asplenia (HP:0001746)1.81947390
151Genital tract atresia (HP:0001827)1.81367336
152Furrowed tongue (HP:0000221)1.80094486
153Metabolic alkalosis (HP:0200114)1.79578510
154Bilateral microphthalmos (HP:0007633)1.79572543
155Vaginal atresia (HP:0000148)1.79502738
156Widely spaced teeth (HP:0000687)1.79177941
157Optic nerve hypoplasia (HP:0000609)1.78814483
158Patellar aplasia (HP:0006443)1.78734364
159Basal ganglia calcification (HP:0002135)1.78214382
160Hyperventilation (HP:0002883)1.77956371
161Morphological abnormality of the middle ear (HP:0008609)1.77703884
162Mitochondrial inheritance (HP:0001427)1.77545451
163Fair hair (HP:0002286)1.77496908
164Deformed sella turcica (HP:0002681)1.77355238
165Protruding tongue (HP:0010808)1.77334214
166Aplasia/Hypoplasia of the patella (HP:0006498)1.77195572
167Disproportionate short-trunk short stature (HP:0003521)1.75790529
168Hypothermia (HP:0002045)1.75448269
169Nephritis (HP:0000123)1.75364092
170Increased CSF lactate (HP:0002490)1.75344989
171Macular degeneration (HP:0000608)1.74022469
172Menorrhagia (HP:0000132)1.73556382
173Postaxial foot polydactyly (HP:0001830)1.73445421
174Adactyly (HP:0009776)1.72224545
175Abnormality of the labia minora (HP:0012880)1.72172178
176Elevated erythrocyte sedimentation rate (HP:0003565)1.71973269
177Agitation (HP:0000713)1.71969408
178Epistaxis (HP:0000421)1.71855762
179IgG deficiency (HP:0004315)1.70307964
180Urinary glycosaminoglycan excretion (HP:0003541)1.70123686
181Mucopolysacchariduria (HP:0008155)1.70123686
182Hypopigmentation of the fundus (HP:0007894)1.69484565
183Abnormality of the pons (HP:0007361)1.69217020
184Abnormal urine output (HP:0012590)1.69119706
185Meningitis (HP:0001287)1.69099629
186Long nose (HP:0003189)1.68087583
187Osteomalacia (HP:0002749)1.68085204
188Myositis (HP:0100614)1.67270083
189Distal lower limb amyotrophy (HP:0008944)1.66657871
190Hemiparesis (HP:0001269)1.66130619
19111 pairs of ribs (HP:0000878)1.65929631
192Ectopic kidney (HP:0000086)1.65929501
193Sensory axonal neuropathy (HP:0003390)1.64820697
194Abnormality of the lumbar spine (HP:0100712)1.63786256
195Recurrent lower respiratory tract infections (HP:0002783)1.63548176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.52114191
2MAP3K64.11166665
3ACVR1B3.19189987
4MAP4K22.91973973
5MAP3K142.85756094
6BMPR1B2.84838373
7RIPK42.64822915
8WNK32.60388791
9DMPK2.55823977
10WNK42.55188956
11TLK12.47729908
12MAP2K32.45011485
13NUAK12.38450994
14IRAK42.28197307
15CAMKK22.04720911
16FGR1.96286838
17OXSR11.95720200
18TAOK31.94851443
19FES1.90861857
20STK391.89527124
21SIK21.87206422
22MAPK131.85474288
23CSF1R1.83200856
24TXK1.79894528
25TRIM281.79016677
26PINK11.76599315
27EPHA31.60451947
28MAP4K11.58098968
29PRPF4B1.57764612
30CASK1.52348519
31JAK31.45986183
32RPS6KA41.43108523
33FRK1.43094649
34DAPK21.41797846
35MAP2K41.40119877
36KIT1.39394934
37ADRBK21.33885680
38IKBKB1.32810893
39NTRK31.31173412
40EPHA41.30997472
41CDK31.27515082
42DYRK21.26796900
43PAK31.23576572
44EIF2AK21.22922669
45MST41.19694217
46MAP2K71.17995803
47EEF2K1.15947583
48ERBB31.13846231
49PIK3CG1.12066565
50MAP3K101.11507146
51MKNK21.10228212
52EPHB11.09164303
53BLK1.07968334
54YES11.07354836
55MAP2K61.03644651
56CSK1.02509362
57INSRR1.02393155
58TRPM71.01615291
59NEK20.98098973
60MAP3K130.96325601
61IRAK20.96050589
62LCK0.94087021
63AKT30.93670433
64TGFBR10.92366610
65ADRBK10.92080365
66OBSCN0.91923112
67MARK20.89979138
68PRKCG0.89802201
69PKN10.87573481
70TIE10.86309172
71GRK10.82039243
72IRAK30.80164668
73LYN0.80048389
74MUSK0.79801786
75NLK0.79273446
76PHKG10.79091682
77PHKG20.79091682
78MAP3K40.78968047
79SYK0.78355390
80TBK10.78063439
81BCR0.75416492
82IRAK10.75113027
83IGF1R0.74284600
84BRD40.73947914
85SGK20.73278033
86MARK10.71945616
87CAMK1G0.71299383
88IKBKE0.70652908
89BMX0.69087047
90JAK20.68977050
91PIK3CA0.68051298
92BRSK20.67492368
93PNCK0.67289665
94PRKCQ0.66304030
95RPS6KA20.66266157
96SGK10.65751551
97BMPR20.65563134
98PRKCI0.64512323
99JAK10.64265863
100FGFR20.64033925
101TEC0.63667459
102CSNK1A1L0.59283406
103MYLK0.59251401
104FYN0.58338171
105CHUK0.57935123
106ITK0.57665449
107BTK0.57454160
108TYK20.56582125
109ZAK0.55500675
110CSNK1G10.55319643
111PRKAA20.54901982
112CLK10.54769803
113RPS6KA50.53946473
114VRK10.52925783
115FER0.52322705
116MAP3K50.52290710
117SIK10.52272860
118CAMK10.51769355
119DYRK30.51139711
120BCKDK0.51103265
121EIF2AK30.50323239
122PRKCE0.49285296
123CSNK1G20.48875451
124CSNK1G30.48157506
125STK38L0.48138385
126PRKCH0.48100648
127STK110.47580888
128PLK20.47346470
129MAPKAPK50.47000492
130SGK4940.46915533
131SGK2230.46915533
132WEE10.46641174
133ZAP700.45978477
134EGFR0.44206148
135PTK2B0.44045406
136CAMK1D0.43751556
137TGFBR20.43200691
138PRKACA0.42495511
139PTK20.41975258
140NTRK20.41963371
141TAF10.41714303
142CAMK40.39768036
143SGK30.39296966
144INSR0.39235932
145CSNK1A10.38738525
146MAPKAPK30.38725908
147CAMKK10.38389445
148CAMK2A0.37864931
149MAP3K120.37690864
150TYRO30.36380684
151MAPK150.35725522
152SIK30.35711789
153MAPK120.35294885
154STK30.35268037
155PRKCA0.33537727
156TAOK20.33065264
157MATK0.32168474
158MAP2K10.30653328
159MKNK10.30434576

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020103.43550893
2Linoleic acid metabolism_Homo sapiens_hsa005912.80757523
3Phototransduction_Homo sapiens_hsa047442.69811013
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61523136
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.61299287
6Leishmaniasis_Homo sapiens_hsa051402.54982264
7Nitrogen metabolism_Homo sapiens_hsa009102.38555397
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20403713
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18390021
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11197150
11Osteoclast differentiation_Homo sapiens_hsa043802.07738584
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00393383
13Oxidative phosphorylation_Homo sapiens_hsa001901.98544537
14Butanoate metabolism_Homo sapiens_hsa006501.97849144
15Basal transcription factors_Homo sapiens_hsa030221.92549249
16Tryptophan metabolism_Homo sapiens_hsa003801.91622515
17Staphylococcus aureus infection_Homo sapiens_hsa051501.78694241
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77473816
19Nicotine addiction_Homo sapiens_hsa050331.75261697
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74239577
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70525647
22Selenocompound metabolism_Homo sapiens_hsa004501.66898627
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64654849
24B cell receptor signaling pathway_Homo sapiens_hsa046621.63785203
25Arachidonic acid metabolism_Homo sapiens_hsa005901.59109951
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58057292
27Tuberculosis_Homo sapiens_hsa051521.50935227
28Chemokine signaling pathway_Homo sapiens_hsa040621.49688647
29Protein export_Homo sapiens_hsa030601.49277050
30Olfactory transduction_Homo sapiens_hsa047401.49112939
31RNA polymerase_Homo sapiens_hsa030201.46796270
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.46783254
33Other glycan degradation_Homo sapiens_hsa005111.43880816
34Homologous recombination_Homo sapiens_hsa034401.43656087
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43419937
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42546236
37Pertussis_Homo sapiens_hsa051331.41690671
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41190461
39Parkinsons disease_Homo sapiens_hsa050121.39168882
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38604267
41Morphine addiction_Homo sapiens_hsa050321.37653342
42Lysosome_Homo sapiens_hsa041421.30735116
43Propanoate metabolism_Homo sapiens_hsa006401.30669356
44Toxoplasmosis_Homo sapiens_hsa051451.28444688
45Allograft rejection_Homo sapiens_hsa053301.26171512
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.25851777
47Complement and coagulation cascades_Homo sapiens_hsa046101.22426110
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22418088
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20997410
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19283082
51African trypanosomiasis_Homo sapiens_hsa051431.18303668
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17814241
53Platelet activation_Homo sapiens_hsa046111.16503121
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.13707633
55Measles_Homo sapiens_hsa051621.11916862
56Graft-versus-host disease_Homo sapiens_hsa053321.09518951
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.09388375
58Chemical carcinogenesis_Homo sapiens_hsa052041.09312021
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.08900295
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08218943
61Primary immunodeficiency_Homo sapiens_hsa053401.07485424
62Glutamatergic synapse_Homo sapiens_hsa047241.06806053
63Serotonergic synapse_Homo sapiens_hsa047261.06804548
64TNF signaling pathway_Homo sapiens_hsa046681.06462767
65Autoimmune thyroid disease_Homo sapiens_hsa053201.04475585
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04018812
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02991515
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01564555
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00700642
70Insulin secretion_Homo sapiens_hsa049111.00491147
71Calcium signaling pathway_Homo sapiens_hsa040201.00455279
72Retinol metabolism_Homo sapiens_hsa008300.99946756
73Viral myocarditis_Homo sapiens_hsa054160.99073772
74RNA degradation_Homo sapiens_hsa030180.98371585
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98259408
76Peroxisome_Homo sapiens_hsa041460.98185704
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97937532
78Cardiac muscle contraction_Homo sapiens_hsa042600.97936063
79Ovarian steroidogenesis_Homo sapiens_hsa049130.97082315
80Glycerolipid metabolism_Homo sapiens_hsa005610.97078213
81Ether lipid metabolism_Homo sapiens_hsa005650.97047870
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95915009
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94815347
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94181683
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93424469
86Huntingtons disease_Homo sapiens_hsa050160.92094789
87Caffeine metabolism_Homo sapiens_hsa002320.92051871
88Influenza A_Homo sapiens_hsa051640.90994681
89Fatty acid biosynthesis_Homo sapiens_hsa000610.89090100
90Dorso-ventral axis formation_Homo sapiens_hsa043200.88878380
91GABAergic synapse_Homo sapiens_hsa047270.87678042
92Regulation of autophagy_Homo sapiens_hsa041400.86556969
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86435463
94Alzheimers disease_Homo sapiens_hsa050100.86031365
95Shigellosis_Homo sapiens_hsa051310.85801336
96Salmonella infection_Homo sapiens_hsa051320.85346114
97Acute myeloid leukemia_Homo sapiens_hsa052210.85275660
98Histidine metabolism_Homo sapiens_hsa003400.83996565
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81410512
100Malaria_Homo sapiens_hsa051440.80568820
101Steroid biosynthesis_Homo sapiens_hsa001000.80380732
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79551146
103Circadian entrainment_Homo sapiens_hsa047130.79525783
104Rheumatoid arthritis_Homo sapiens_hsa053230.79359501
105Taste transduction_Homo sapiens_hsa047420.78826329
106Phagosome_Homo sapiens_hsa041450.78731398
107Lysine degradation_Homo sapiens_hsa003100.78458339
108cAMP signaling pathway_Homo sapiens_hsa040240.76955564
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.76519524
110Collecting duct acid secretion_Homo sapiens_hsa049660.75596696
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75068072
112Fat digestion and absorption_Homo sapiens_hsa049750.72187359
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71902031
114Type I diabetes mellitus_Homo sapiens_hsa049400.71544431
115T cell receptor signaling pathway_Homo sapiens_hsa046600.71320730
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71176671
117One carbon pool by folate_Homo sapiens_hsa006700.69654483
118Axon guidance_Homo sapiens_hsa043600.69587227
119Inositol phosphate metabolism_Homo sapiens_hsa005620.69277207
120Cocaine addiction_Homo sapiens_hsa050300.69154024
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.67903098
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67202009
123Fatty acid metabolism_Homo sapiens_hsa012120.66995606
124VEGF signaling pathway_Homo sapiens_hsa043700.66935290
125Renin secretion_Homo sapiens_hsa049240.66844324
126Prolactin signaling pathway_Homo sapiens_hsa049170.66225455
127Pancreatic cancer_Homo sapiens_hsa052120.65111573
128Antigen processing and presentation_Homo sapiens_hsa046120.65097048
129beta-Alanine metabolism_Homo sapiens_hsa004100.64944417
130Asthma_Homo sapiens_hsa053100.64751933
131Legionellosis_Homo sapiens_hsa051340.64325339
132Mineral absorption_Homo sapiens_hsa049780.63130781
133Long-term depression_Homo sapiens_hsa047300.62572310
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60347699
135Type II diabetes mellitus_Homo sapiens_hsa049300.59830117
136Cholinergic synapse_Homo sapiens_hsa047250.59523650
137Sulfur metabolism_Homo sapiens_hsa009200.59385228
138Apoptosis_Homo sapiens_hsa042100.59290686
139Salivary secretion_Homo sapiens_hsa049700.58515897
140Amoebiasis_Homo sapiens_hsa051460.58092953
141Dopaminergic synapse_Homo sapiens_hsa047280.55986195
142Prostate cancer_Homo sapiens_hsa052150.54736245
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.54590997
144Sphingolipid metabolism_Homo sapiens_hsa006000.53942299
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53881970
146Herpes simplex infection_Homo sapiens_hsa051680.53190685
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52881626
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.52347780
149Vitamin digestion and absorption_Homo sapiens_hsa049770.51661568
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51456733
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47777812
152Metabolic pathways_Homo sapiens_hsa011000.46579010
153Phenylalanine metabolism_Homo sapiens_hsa003600.46282814
154Fanconi anemia pathway_Homo sapiens_hsa034600.46132626
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40230699
156Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38408746
157Amphetamine addiction_Homo sapiens_hsa050310.38026959
158Circadian rhythm_Homo sapiens_hsa047100.36736244
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.35763738
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.35184982
161Purine metabolism_Homo sapiens_hsa002300.34542412
162Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32886097
163Cysteine and methionine metabolism_Homo sapiens_hsa002700.31401030

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