

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation by symbiont of host defense response (GO:0052509) | 7.97476073 |
| 2 | modulation by symbiont of host defense response (GO:0052031) | 7.97476073 |
| 3 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 7.97476073 |
| 4 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 7.97476073 |
| 5 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 7.97476073 |
| 6 | modulation by symbiont of host immune response (GO:0052553) | 7.97476073 |
| 7 | response to peptidoglycan (GO:0032494) | 6.89404292 |
| 8 | macrophage activation involved in immune response (GO:0002281) | 5.79706027 |
| 9 | positive regulation of chemokine biosynthetic process (GO:0045080) | 5.78919485 |
| 10 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 5.45727992 |
| 11 | response to host immune response (GO:0052572) | 5.45727992 |
| 12 | neutrophil activation involved in immune response (GO:0002283) | 5.19213136 |
| 13 | microglial cell activation (GO:0001774) | 4.97051969 |
| 14 | hydrogen peroxide biosynthetic process (GO:0050665) | 4.96739421 |
| 15 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 4.91116949 |
| 16 | response to host (GO:0075136) | 4.91116949 |
| 17 | response to host defenses (GO:0052200) | 4.91116949 |
| 18 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 4.88094608 |
| 19 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.81687659 |
| 20 | respiratory burst (GO:0045730) | 4.75436902 |
| 21 | regulation of chemokine biosynthetic process (GO:0045073) | 4.73998045 |
| 22 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 4.71657735 |
| 23 | immunoglobulin mediated immune response (GO:0016064) | 4.49434840 |
| 24 | positive regulation of interferon-alpha production (GO:0032727) | 4.48970408 |
| 25 | reactive oxygen species biosynthetic process (GO:1903409) | 4.45573243 |
| 26 | positive regulation of heat generation (GO:0031652) | 4.45566997 |
| 27 | regulation of vitamin metabolic process (GO:0030656) | 4.43496393 |
| 28 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.37887145 |
| 29 | regulation of interferon-alpha production (GO:0032647) | 4.33627627 |
| 30 | positive regulation of cellular amide metabolic process (GO:0034250) | 4.29658582 |
| 31 | regulation of fever generation (GO:0031620) | 4.25263824 |
| 32 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 4.16530230 |
| 33 | superoxide anion generation (GO:0042554) | 4.12531520 |
| 34 | macrophage activation (GO:0042116) | 4.11690588 |
| 35 | negative regulation of interleukin-12 production (GO:0032695) | 4.07869479 |
| 36 | regulation of cytokine secretion involved in immune response (GO:0002739) | 4.05064114 |
| 37 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.93881836 |
| 38 | monocyte chemotaxis (GO:0002548) | 3.93351684 |
| 39 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 3.90525138 |
| 40 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.88314913 |
| 41 | positive regulation of mast cell degranulation (GO:0043306) | 3.88314913 |
| 42 | myeloid cell activation involved in immune response (GO:0002275) | 3.83969823 |
| 43 | negative regulation of interleukin-17 production (GO:0032700) | 3.83158103 |
| 44 | granulocyte activation (GO:0036230) | 3.81707596 |
| 45 | leukocyte aggregation (GO:0070486) | 3.81231697 |
| 46 | detection of molecule of bacterial origin (GO:0032490) | 3.78895119 |
| 47 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.75627533 |
| 48 | regulation of podosome assembly (GO:0071801) | 3.67591533 |
| 49 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.64938653 |
| 50 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.64625634 |
| 51 | response to muramyl dipeptide (GO:0032495) | 3.63876014 |
| 52 | NIK/NF-kappaB signaling (GO:0038061) | 3.62544735 |
| 53 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.60489981 |
| 54 | positive regulation of chemokine production (GO:0032722) | 3.57246737 |
| 55 | germinal center formation (GO:0002467) | 3.56083144 |
| 56 | positive regulation of interferon-beta production (GO:0032728) | 3.55997455 |
| 57 | positive regulation of mast cell activation (GO:0033005) | 3.51217861 |
| 58 | neutrophil activation (GO:0042119) | 3.50149249 |
| 59 | regulation of mast cell degranulation (GO:0043304) | 3.49949049 |
| 60 | I-kappaB phosphorylation (GO:0007252) | 3.48804894 |
| 61 | cellular response to type I interferon (GO:0071357) | 3.47323339 |
| 62 | type I interferon signaling pathway (GO:0060337) | 3.47323339 |
| 63 | regulation of mononuclear cell migration (GO:0071675) | 3.44606413 |
| 64 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.44335172 |
| 65 | response to type I interferon (GO:0034340) | 3.43234517 |
| 66 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.42746752 |
| 67 | response to protozoan (GO:0001562) | 3.38509728 |
| 68 | myeloid dendritic cell differentiation (GO:0043011) | 3.37299151 |
| 69 | positive regulation of antigen processing and presentation (GO:0002579) | 3.36154870 |
| 70 | regulation of heat generation (GO:0031650) | 3.35127985 |
| 71 | B cell mediated immunity (GO:0019724) | 3.33827925 |
| 72 | glycosphingolipid catabolic process (GO:0046479) | 3.30024726 |
| 73 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.28436190 |
| 74 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 3.27758971 |
| 75 | positive regulation of acute inflammatory response (GO:0002675) | 3.27688869 |
| 76 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.27296819 |
| 77 | lymphocyte chemotaxis (GO:0048247) | 3.27252881 |
| 78 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 3.23015377 |
| 79 | regulation of growth of symbiont in host (GO:0044126) | 3.23015377 |
| 80 | negative regulation of growth of symbiont in host (GO:0044130) | 3.23015377 |
| 81 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 3.23015377 |
| 82 | regulation of macrophage chemotaxis (GO:0010758) | 3.22770672 |
| 83 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.21234541 |
| 84 | cellular response to thyroid hormone stimulus (GO:0097067) | 3.20111677 |
| 85 | positive regulation of leukocyte degranulation (GO:0043302) | 3.18860245 |
| 86 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.18527531 |
| 87 | positive regulation of type 2 immune response (GO:0002830) | 3.16655538 |
| 88 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.16481464 |
| 89 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.16239007 |
| 90 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.15647368 |
| 91 | response to interferon-alpha (GO:0035455) | 3.14086724 |
| 92 | neutrophil mediated immunity (GO:0002446) | 3.13939473 |
| 93 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 3.13791957 |
| 94 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.12106691 |
| 95 | T-helper 1 type immune response (GO:0042088) | 3.11519875 |
| 96 | regulation of interleukin-17 production (GO:0032660) | 3.11437890 |
| 97 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.11147233 |
| 98 | cellular extravasation (GO:0045123) | 3.08835469 |
| 99 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 3.08723996 |
| 100 | low-density lipoprotein particle clearance (GO:0034383) | 3.08529721 |
| 101 | neutrophil chemotaxis (GO:0030593) | 3.08170523 |
| 102 | positive regulation of interleukin-6 production (GO:0032755) | 3.07790595 |
| 103 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.07606819 |
| 104 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.07374605 |
| 105 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.07063177 |
| 106 | regulation of chronic inflammatory response (GO:0002676) | 3.06293714 |
| 107 | eosinophil chemotaxis (GO:0048245) | 3.05728009 |
| 108 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 3.03133824 |
| 109 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.02619255 |
| 110 | regulation of heterotypic cell-cell adhesion (GO:0034114) | 3.01760939 |
| 111 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.01667462 |
| 112 | negative regulation of viral genome replication (GO:0045071) | 2.99890286 |
| 113 | oligosaccharide catabolic process (GO:0009313) | 2.99787100 |
| 114 | regulation of nitric oxide biosynthetic process (GO:0045428) | 2.99691246 |
| 115 | regulation of interleukin-12 production (GO:0032655) | 2.99601940 |
| 116 | neutrophil migration (GO:1990266) | 2.99438168 |
| 117 | myeloid dendritic cell activation (GO:0001773) | 2.98996507 |
| 118 | negative regulation of cell killing (GO:0031342) | 2.98492054 |
| 119 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.98492054 |
| 120 | regulation of mast cell activation (GO:0033003) | 2.96458321 |
| 121 | cellular response to lipopolysaccharide (GO:0071222) | 2.96252404 |
| 122 | defense response to protozoan (GO:0042832) | 2.96235567 |
| 123 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 2.95221887 |
| 124 | cellular response to molecule of bacterial origin (GO:0071219) | 2.94275322 |
| 125 | glycolipid catabolic process (GO:0019377) | 2.94121721 |
| 126 | negative regulation of production of molecular mediator of immune response (GO:0002701) | 2.92789188 |
| 127 | positive regulation of nitric oxide biosynthetic process (GO:0045429) | 2.90975072 |
| 128 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.90663520 |
| 129 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.89723030 |
| 130 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.89652601 |
| 131 | regulation of NF-kappaB import into nucleus (GO:0042345) | 2.87999214 |
| 132 | detection of other organism (GO:0098543) | 2.81803402 |
| 133 | regulation of lymphocyte chemotaxis (GO:1901623) | 2.81027114 |
| 134 | cellular response to biotic stimulus (GO:0071216) | 2.80967730 |
| 135 | negative regulation of lipid storage (GO:0010888) | 2.79787611 |
| 136 | detection of external biotic stimulus (GO:0098581) | 2.79702927 |
| 137 | regulation of antigen processing and presentation (GO:0002577) | 2.77958989 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 7.46059265 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 7.38443366 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.64196208 |
| 4 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.77969548 |
| 5 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.46565911 |
| 6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.41528454 |
| 7 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.02642664 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.93809027 |
| 9 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.71179824 |
| 10 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.68357449 |
| 11 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.25566103 |
| 12 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 3.18885022 |
| 13 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.15055410 |
| 14 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.72148020 |
| 15 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.63365889 |
| 16 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.59524783 |
| 17 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.58543340 |
| 18 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.54773215 |
| 19 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.39617423 |
| 20 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.31643146 |
| 21 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.19041146 |
| 22 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.07119233 |
| 23 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.03694007 |
| 24 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 2.00366087 |
| 25 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.98876035 |
| 26 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.97914691 |
| 27 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.86538560 |
| 28 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.80052522 |
| 29 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.78218173 |
| 30 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.75994397 |
| 31 | SPI1_23127762_ChIP-Seq_K562_Human | 1.75958301 |
| 32 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.69769179 |
| 33 | * CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.64022331 |
| 34 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.62153436 |
| 35 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59875910 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.57690405 |
| 37 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.56571081 |
| 38 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.53545795 |
| 39 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.52090188 |
| 40 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.41270734 |
| 41 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.39817143 |
| 42 | MYB_26560356_Chip-Seq_TH2_Human | 1.37202730 |
| 43 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 1.35995294 |
| 44 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.35710394 |
| 45 | * CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.33376181 |
| 46 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.31682609 |
| 47 | MAF_26560356_Chip-Seq_TH1_Human | 1.29289528 |
| 48 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.25851371 |
| 49 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.25090177 |
| 50 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.22011256 |
| 51 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.20321496 |
| 52 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.17443870 |
| 53 | * SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.16986769 |
| 54 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16972588 |
| 55 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.16293879 |
| 56 | GATA1_22025678_ChIP-Seq_K562_Human | 1.15501128 |
| 57 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.15189286 |
| 58 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.13282259 |
| 59 | * PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.12534723 |
| 60 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.10985111 |
| 61 | GATA3_26560356_Chip-Seq_TH2_Human | 1.09853204 |
| 62 | MYB_26560356_Chip-Seq_TH1_Human | 1.09836435 |
| 63 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.07314743 |
| 64 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.06273840 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05705312 |
| 66 | MYC_22102868_ChIP-Seq_BL_Human | 1.05317735 |
| 67 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.04881771 |
| 68 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.04675328 |
| 69 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.03239609 |
| 70 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.02837445 |
| 71 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.01985818 |
| 72 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.00402272 |
| 73 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95736452 |
| 74 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95716887 |
| 75 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.94412243 |
| 76 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.93901041 |
| 77 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.92039051 |
| 78 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.91518731 |
| 79 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88664106 |
| 80 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.87933966 |
| 81 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.87259671 |
| 82 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86390992 |
| 83 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.85162860 |
| 84 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.84462706 |
| 85 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.84154928 |
| 86 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84089954 |
| 87 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84055622 |
| 88 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.83414256 |
| 89 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.82869020 |
| 90 | * BCOR_27268052_Chip-Seq_Bcells_Human | 0.82742970 |
| 91 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.82527026 |
| 92 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.82207064 |
| 93 | GATA2_19941826_ChIP-Seq_K562_Human | 0.78981757 |
| 94 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.77870184 |
| 95 | GATA1_19941826_ChIP-Seq_K562_Human | 0.77397723 |
| 96 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77084890 |
| 97 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 0.76776506 |
| 98 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.74167128 |
| 99 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.74167128 |
| 100 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.74153624 |
| 101 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.73562507 |
| 102 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.73522713 |
| 103 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.73375347 |
| 104 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.72170713 |
| 105 | MAF_26560356_Chip-Seq_TH2_Human | 0.71899217 |
| 106 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.71291225 |
| 107 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.66282662 |
| 108 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.65134267 |
| 109 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.62943880 |
| 110 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.62269728 |
| 111 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.61461569 |
| 112 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.59975626 |
| 113 | * CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.59197328 |
| 114 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.58738410 |
| 115 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.58319558 |
| 116 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.57562902 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009785_altered_susceptibility_to | 4.34253852 |
| 2 | MP0003303_peritoneal_inflammation | 4.14937252 |
| 3 | MP0003436_decreased_susceptibility_to | 4.06867515 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.71954473 |
| 5 | MP0006082_CNS_inflammation | 3.59751780 |
| 6 | MP0002419_abnormal_innate_immunity | 3.43364374 |
| 7 | MP0002148_abnormal_hypersensitivity_rea | 3.32514264 |
| 8 | MP0003724_increased_susceptibility_to | 3.21383189 |
| 9 | MP0005000_abnormal_immune_tolerance | 3.10289384 |
| 10 | MP0005058_abnormal_lysosome_morphology | 3.08812375 |
| 11 | MP0005025_abnormal_response_to | 2.99135323 |
| 12 | MP0001790_abnormal_immune_system | 2.60838235 |
| 13 | MP0005387_immune_system_phenotype | 2.60838235 |
| 14 | MP0004510_myositis | 2.50169312 |
| 15 | MP0002452_abnormal_antigen_presenting | 2.49562393 |
| 16 | MP0003172_abnormal_lysosome_physiology | 2.48848266 |
| 17 | MP0001533_abnormal_skeleton_physiology | 2.45232766 |
| 18 | MP0002723_abnormal_immune_serum | 2.39471113 |
| 19 | MP0001800_abnormal_humoral_immune | 2.29484022 |
| 20 | MP0003075_altered_response_to | 2.27516045 |
| 21 | MP0005464_abnormal_platelet_physiology | 2.25083592 |
| 22 | MP0009764_decreased_sensitivity_to | 2.24759023 |
| 23 | MP0002139_abnormal_hepatobiliary_system | 2.19018000 |
| 24 | MP0000685_abnormal_immune_system | 2.16213288 |
| 25 | MP0004947_skin_inflammation | 2.14022734 |
| 26 | MP0000343_altered_response_to | 2.12070667 |
| 27 | MP0009278_abnormal_bone_marrow | 2.11331826 |
| 28 | MP0005671_abnormal_response_to | 2.07711365 |
| 29 | MP0005167_abnormal_blood-brain_barrier | 2.04958653 |
| 30 | MP0001819_abnormal_immune_cell | 2.04348305 |
| 31 | MP0002420_abnormal_adaptive_immunity | 2.01340176 |
| 32 | MP0000604_amyloidosis | 1.97007116 |
| 33 | MP0001845_abnormal_inflammatory_respons | 1.96127342 |
| 34 | MP0008469_abnormal_protein_level | 1.91375067 |
| 35 | MP0003448_altered_tumor_morphology | 1.86243047 |
| 36 | MP0003195_calcinosis | 1.83831652 |
| 37 | MP0004858_abnormal_nervous_system | 1.77903289 |
| 38 | MP0002405_respiratory_system_inflammati | 1.77634191 |
| 39 | MP0009840_abnormal_foam_cell | 1.76518813 |
| 40 | MP0008004_abnormal_stomach_pH | 1.75640337 |
| 41 | MP0003806_abnormal_nucleotide_metabolis | 1.72176704 |
| 42 | MP0003191_abnormal_cellular_cholesterol | 1.71324849 |
| 43 | MP0001853_heart_inflammation | 1.63318211 |
| 44 | MP0006054_spinal_hemorrhage | 1.55308504 |
| 45 | MP0005166_decreased_susceptibility_to | 1.52906340 |
| 46 | MP0002998_abnormal_bone_remodeling | 1.46637494 |
| 47 | MP0010155_abnormal_intestine_physiology | 1.45469079 |
| 48 | MP0003828_pulmonary_edema | 1.44713653 |
| 49 | MP0002006_tumorigenesis | 1.43885871 |
| 50 | MP0009333_abnormal_splenocyte_physiolog | 1.43425988 |
| 51 | MP0003690_abnormal_glial_cell | 1.39466025 |
| 52 | MP0000858_altered_metastatic_potential | 1.39289873 |
| 53 | MP0005164_abnormal_response_to | 1.38060159 |
| 54 | MP0003300_gastrointestinal_ulcer | 1.37127327 |
| 55 | MP0000716_abnormal_immune_system | 1.36449368 |
| 56 | MP0005310_abnormal_salivary_gland | 1.32900264 |
| 57 | MP0003183_abnormal_peptide_metabolism | 1.32726949 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.27838342 |
| 59 | MP0001545_abnormal_hematopoietic_system | 1.27838342 |
| 60 | MP0002398_abnormal_bone_marrow | 1.20547408 |
| 61 | MP0002277_abnormal_respiratory_mucosa | 1.15961438 |
| 62 | MP0005390_skeleton_phenotype | 1.11859652 |
| 63 | MP0003186_abnormal_redox_activity | 1.10376176 |
| 64 | MP0003646_muscle_fatigue | 1.09259020 |
| 65 | MP0009763_increased_sensitivity_to | 1.08616421 |
| 66 | MP0002429_abnormal_blood_cell | 1.06119612 |
| 67 | MP0000689_abnormal_spleen_morphology | 1.06051641 |
| 68 | MP0005083_abnormal_biliary_tract | 1.03056076 |
| 69 | MP0002332_abnormal_exercise_endurance | 1.02407856 |
| 70 | MP0001851_eye_inflammation | 1.02117467 |
| 71 | MP0005076_abnormal_cell_differentiation | 1.01194107 |
| 72 | MP0001501_abnormal_sleep_pattern | 0.99401456 |
| 73 | MP0000569_abnormal_digit_pigmentation | 0.96069875 |
| 74 | MP0010307_abnormal_tumor_latency | 0.93462431 |
| 75 | MP0002933_joint_inflammation | 0.92103542 |
| 76 | MP0002722_abnormal_immune_system | 0.91122516 |
| 77 | MP0009765_abnormal_xenobiotic_induced | 0.89253111 |
| 78 | MP0000249_abnormal_blood_vessel | 0.87388032 |
| 79 | MP0002138_abnormal_hepatobiliary_system | 0.86451111 |
| 80 | MP0001542_abnormal_bone_strength | 0.84936960 |
| 81 | MP0003656_abnormal_erythrocyte_physiolo | 0.84376914 |
| 82 | MP0004782_abnormal_surfactant_physiolog | 0.84191615 |
| 83 | MP0005257_abnormal_intraocular_pressure | 0.82631912 |
| 84 | MP0001663_abnormal_digestive_system | 0.81802008 |
| 85 | MP0003453_abnormal_keratinocyte_physiol | 0.79395457 |
| 86 | MP0003566_abnormal_cell_adhesion | 0.77740070 |
| 87 | MP0005023_abnormal_wound_healing | 0.77171934 |
| 88 | MP0003091_abnormal_cell_migration | 0.76161914 |
| 89 | MP0002254_reproductive_system_inflammat | 0.74576679 |
| 90 | MP0008874_decreased_physiological_sensi | 0.74355057 |
| 91 | MP0002837_dystrophic_cardiac_calcinosis | 0.73339335 |
| 92 | MP0003329_amyloid_beta_deposits | 0.72259506 |
| 93 | MP0008260_abnormal_autophagy | 0.70473923 |
| 94 | MP0002166_altered_tumor_susceptibility | 0.69539009 |
| 95 | MP0003795_abnormal_bone_structure | 0.66035067 |
| 96 | MP0004883_abnormal_blood_vessel | 0.64169510 |
| 97 | MP0005647_abnormal_sex_gland | 0.63383043 |
| 98 | MP0008873_increased_physiological_sensi | 0.63357676 |
| 99 | MP0000465_gastrointestinal_hemorrhage | 0.61536658 |
| 100 | MP0000920_abnormal_myelination | 0.59171328 |
| 101 | MP0005319_abnormal_enzyme/_coenzyme | 0.58173744 |
| 102 | MP0002090_abnormal_vision | 0.57585112 |
| 103 | MP0000371_diluted_coat_color | 0.56974476 |
| 104 | MP0003221_abnormal_cardiomyocyte_apopto | 0.56755667 |
| 105 | MP0004808_abnormal_hematopoietic_stem | 0.56440644 |
| 106 | MP0005595_abnormal_vascular_smooth | 0.56415056 |
| 107 | MP0003763_abnormal_thymus_physiology | 0.55884285 |
| 108 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.54836368 |
| 109 | MP0005165_increased_susceptibility_to | 0.54803850 |
| 110 | MP0001873_stomach_inflammation | 0.54381565 |
| 111 | MP0002136_abnormal_kidney_physiology | 0.53952513 |
| 112 | MP0005451_abnormal_body_composition | 0.53839870 |
| 113 | MP0000767_abnormal_smooth_muscle | 0.51919832 |
| 114 | MP0005535_abnormal_body_temperature | 0.50484377 |
| 115 | MP0005174_abnormal_tail_pigmentation | 0.49438043 |
| 116 | MP0000609_abnormal_liver_physiology | 0.49365337 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 8.18855277 |
| 2 | Eczematoid dermatitis (HP:0000976) | 7.53976575 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 7.32370818 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 6.78245556 |
| 5 | Abnormality of macrophages (HP:0004311) | 5.73702484 |
| 6 | Mediastinal lymphadenopathy (HP:0100721) | 5.71809938 |
| 7 | Stomatitis (HP:0010280) | 5.29078367 |
| 8 | Systemic lupus erythematosus (HP:0002725) | 5.26433253 |
| 9 | Increased cerebral lipofuscin (HP:0011813) | 4.97177220 |
| 10 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 4.71617848 |
| 11 | Autoimmune thrombocytopenia (HP:0001973) | 4.61267980 |
| 12 | Gingivitis (HP:0000230) | 4.42796217 |
| 13 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.38623390 |
| 14 | Recurrent skin infections (HP:0001581) | 4.16286012 |
| 15 | Obstructive lung disease (HP:0006536) | 4.15514136 |
| 16 | Chronic obstructive pulmonary disease (HP:0006510) | 4.15514136 |
| 17 | Orchitis (HP:0100796) | 4.09176090 |
| 18 | Glomerulonephritis (HP:0000099) | 4.07651849 |
| 19 | Vacuolated lymphocytes (HP:0001922) | 4.02803992 |
| 20 | Myositis (HP:0100614) | 3.98803776 |
| 21 | Mutism (HP:0002300) | 3.96883162 |
| 22 | Retrobulbar optic neuritis (HP:0100654) | 3.79336032 |
| 23 | Optic neuritis (HP:0100653) | 3.79336032 |
| 24 | Axonal loss (HP:0003447) | 3.70982021 |
| 25 | Disinhibition (HP:0000734) | 3.53868698 |
| 26 | Prostate neoplasm (HP:0100787) | 3.52750328 |
| 27 | Neurofibrillary tangles (HP:0002185) | 3.40570926 |
| 28 | Urticaria (HP:0001025) | 3.39909674 |
| 29 | Vasculitis (HP:0002633) | 3.36696116 |
| 30 | Thick nail (HP:0001805) | 3.35592003 |
| 31 | Recurrent fungal infections (HP:0002841) | 3.33929785 |
| 32 | Increased IgM level (HP:0003496) | 3.33879933 |
| 33 | Tetraparesis (HP:0002273) | 3.32124742 |
| 34 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 3.31244122 |
| 35 | Nuclear cataract (HP:0100018) | 3.20796239 |
| 36 | Recurrent viral infections (HP:0004429) | 3.11730573 |
| 37 | Pustule (HP:0200039) | 3.09722844 |
| 38 | Dysostosis multiplex (HP:0000943) | 3.09563009 |
| 39 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.09113489 |
| 40 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.09113489 |
| 41 | Abnormality of glycolipid metabolism (HP:0010969) | 3.09113489 |
| 42 | Basal ganglia calcification (HP:0002135) | 3.08189956 |
| 43 | Cellulitis (HP:0100658) | 3.03508253 |
| 44 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 3.01450101 |
| 45 | Interstitial pulmonary disease (HP:0006530) | 2.93075478 |
| 46 | Pulmonary infiltrates (HP:0002113) | 2.81899498 |
| 47 | Agnosia (HP:0010524) | 2.74173283 |
| 48 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.73317034 |
| 49 | Periodontitis (HP:0000704) | 2.67352279 |
| 50 | Myocardial infarction (HP:0001658) | 2.60251412 |
| 51 | Nephritis (HP:0000123) | 2.59581239 |
| 52 | Neuronal loss in central nervous system (HP:0002529) | 2.57821104 |
| 53 | Hepatosplenomegaly (HP:0001433) | 2.56522003 |
| 54 | Recurrent pneumonia (HP:0006532) | 2.55478624 |
| 55 | Inappropriate behavior (HP:0000719) | 2.53022563 |
| 56 | Metaphyseal irregularity (HP:0003025) | 2.51779123 |
| 57 | Hematochezia (HP:0002573) | 2.49648015 |
| 58 | Mucopolysacchariduria (HP:0008155) | 2.48496560 |
| 59 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.48496560 |
| 60 | Gangrene (HP:0100758) | 2.48381604 |
| 61 | Purpura (HP:0000979) | 2.48026501 |
| 62 | Progressive neurologic deterioration (HP:0002344) | 2.46069711 |
| 63 | Meningitis (HP:0001287) | 2.44990327 |
| 64 | Chronic otitis media (HP:0000389) | 2.44414643 |
| 65 | Neoplasm of head and neck (HP:0012288) | 2.44161538 |
| 66 | Esophageal neoplasm (HP:0100751) | 2.44161538 |
| 67 | Nausea (HP:0002018) | 2.44033902 |
| 68 | Osteomyelitis (HP:0002754) | 2.43953297 |
| 69 | Leukocytosis (HP:0001974) | 2.43275840 |
| 70 | Abnormality of iron homeostasis (HP:0011031) | 2.42863254 |
| 71 | Polyneuropathy (HP:0001271) | 2.39580288 |
| 72 | Cerebral inclusion bodies (HP:0100314) | 2.39361958 |
| 73 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.33340499 |
| 74 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.33340499 |
| 75 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.33340499 |
| 76 | Arterial thrombosis (HP:0004420) | 2.27680594 |
| 77 | Abnormality of complement system (HP:0005339) | 2.21181428 |
| 78 | Hypergammaglobulinemia (HP:0010702) | 2.20937930 |
| 79 | Osteolytic defects of the hand bones (HP:0009699) | 2.20476669 |
| 80 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.20476669 |
| 81 | Upper motor neuron abnormality (HP:0002127) | 2.20393418 |
| 82 | Malnutrition (HP:0004395) | 2.18274925 |
| 83 | Complement deficiency (HP:0004431) | 2.17779181 |
| 84 | Keratoconjunctivitis sicca (HP:0001097) | 2.16407909 |
| 85 | Premature loss of primary teeth (HP:0006323) | 2.15916021 |
| 86 | Amyloidosis (HP:0011034) | 2.15890902 |
| 87 | Recurrent lower respiratory tract infections (HP:0002783) | 2.15748845 |
| 88 | Loss of speech (HP:0002371) | 2.14652596 |
| 89 | Personality changes (HP:0000751) | 2.13351477 |
| 90 | Gingival bleeding (HP:0000225) | 2.12179805 |
| 91 | Bone pain (HP:0002653) | 2.10805424 |
| 92 | Spontaneous hematomas (HP:0007420) | 2.10520819 |
| 93 | Episodic fever (HP:0001954) | 2.07581464 |
| 94 | Encephalitis (HP:0002383) | 2.06921922 |
| 95 | Progressive visual loss (HP:0000529) | 2.03864459 |
| 96 | Pathologic fracture (HP:0002756) | 2.02861287 |
| 97 | Memory impairment (HP:0002354) | 2.00515627 |
| 98 | Recurrent cutaneous fungal infections (HP:0011370) | 1.99873059 |
| 99 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.99873059 |
| 100 | Prolonged neonatal jaundice (HP:0006579) | 1.99534209 |
| 101 | T lymphocytopenia (HP:0005403) | 1.99353287 |
| 102 | Dementia (HP:0000726) | 1.97687130 |
| 103 | Peritonitis (HP:0002586) | 1.96346742 |
| 104 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.96248039 |
| 105 | Anorexia (HP:0002039) | 1.95587439 |
| 106 | Keratoconjunctivitis (HP:0001096) | 1.94379398 |
| 107 | Abnormality of the prostate (HP:0008775) | 1.93724274 |
| 108 | Parakeratosis (HP:0001036) | 1.93440387 |
| 109 | Increased serum ferritin (HP:0003281) | 1.92405245 |
| 110 | Gastrointestinal infarctions (HP:0005244) | 1.92067876 |
| 111 | Increased IgE level (HP:0003212) | 1.91525706 |
| 112 | Vertigo (HP:0002321) | 1.91110772 |
| 113 | Joint swelling (HP:0001386) | 1.91012022 |
| 114 | Joint hemorrhage (HP:0005261) | 1.89861978 |
| 115 | Petechiae (HP:0000967) | 1.88202280 |
| 116 | Pulmonary embolism (HP:0002204) | 1.87644502 |
| 117 | Peripheral demyelination (HP:0011096) | 1.86923863 |
| 118 | Arthralgia (HP:0002829) | 1.86639678 |
| 119 | Apathy (HP:0000741) | 1.86018851 |
| 120 | Supranuclear gaze palsy (HP:0000605) | 1.85295383 |
| 121 | Hemoptysis (HP:0002105) | 1.85249166 |
| 122 | Restrictive lung disease (HP:0002091) | 1.84409503 |
| 123 | Asymmetric septal hypertrophy (HP:0001670) | 1.84103039 |
| 124 | Autoimmune hemolytic anemia (HP:0001890) | 1.83940611 |
| 125 | Eosinophilia (HP:0001880) | 1.83234871 |
| 126 | Abnormality of the pleura (HP:0002103) | 1.81470218 |
| 127 | Skin ulcer (HP:0200042) | 1.81354045 |
| 128 | Abnormality of the pericardium (HP:0001697) | 1.81052176 |
| 129 | Diminished motivation (HP:0000745) | 1.80848715 |
| 130 | Sepsis (HP:0100806) | 1.78620485 |
| 131 | Colitis (HP:0002583) | 1.77773355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 5.45514826 |
| 2 | MAP3K14 | 4.08308987 |
| 3 | IRAK3 | 3.88176691 |
| 4 | TBK1 | 3.84108876 |
| 5 | BLK | 3.81458289 |
| 6 | IRAK4 | 3.35244405 |
| 7 | TYK2 | 3.21699719 |
| 8 | DDR2 | 2.80330443 |
| 9 | IKBKE | 2.78118325 |
| 10 | MAP4K1 | 2.56440169 |
| 11 | TXK | 2.51128389 |
| 12 | FGR | 2.35885201 |
| 13 | ERN1 | 2.30270112 |
| 14 | KIT | 2.20702362 |
| 15 | IKBKB | 2.12292842 |
| 16 | CSK | 2.04537302 |
| 17 | PBK | 2.03721314 |
| 18 | JAK3 | 2.00397027 |
| 19 | PRPF4B | 1.90405088 |
| 20 | JAK1 | 1.89541447 |
| 21 | FES | 1.75795898 |
| 22 | CSF1R | 1.69527677 |
| 23 | MAP3K13 | 1.47106542 |
| 24 | ZAP70 | 1.46075909 |
| 25 | HCK | 1.45710783 |
| 26 | MATK | 1.44825652 |
| 27 | EPHB1 | 1.43362583 |
| 28 | CDC42BPA | 1.41774309 |
| 29 | PIM2 | 1.39849257 |
| 30 | TGFBR2 | 1.36572043 |
| 31 | RPS6KA4 | 1.35073230 |
| 32 | LYN | 1.33137596 |
| 33 | SYK | 1.32332840 |
| 34 | ADRBK2 | 1.25960801 |
| 35 | CHUK | 1.22894020 |
| 36 | ACVR1B | 1.15931127 |
| 37 | JAK2 | 1.10574140 |
| 38 | MARK3 | 1.08100506 |
| 39 | LCK | 1.07418130 |
| 40 | STK10 | 0.94620790 |
| 41 | BMX | 0.94240011 |
| 42 | PRKCD | 0.90306926 |
| 43 | MAP3K11 | 0.88687611 |
| 44 | EGFR | 0.87938079 |
| 45 | EIF2AK2 | 0.86642220 |
| 46 | MAP3K5 | 0.84866055 |
| 47 | TYRO3 | 0.82029028 |
| 48 | ABL2 | 0.81462388 |
| 49 | BTK | 0.79376419 |
| 50 | NEK9 | 0.79142584 |
| 51 | CAMK1D | 0.77879559 |
| 52 | YES1 | 0.75639199 |
| 53 | SIK2 | 0.73790884 |
| 54 | NME2 | 0.71320515 |
| 55 | MAP3K3 | 0.69847938 |
| 56 | CLK1 | 0.67916149 |
| 57 | ABL1 | 0.67340030 |
| 58 | TESK2 | 0.66780296 |
| 59 | LATS2 | 0.66765239 |
| 60 | GRK7 | 0.65322849 |
| 61 | FGFR4 | 0.64946752 |
| 62 | BMPR2 | 0.64590049 |
| 63 | PIM1 | 0.63939696 |
| 64 | MAP3K1 | 0.61225131 |
| 65 | PRKG2 | 0.61189209 |
| 66 | MAP2K6 | 0.60399035 |
| 67 | TAOK3 | 0.59233627 |
| 68 | KSR2 | 0.59231967 |
| 69 | ALK | 0.55366972 |
| 70 | MST1R | 0.54971358 |
| 71 | ERBB4 | 0.54153229 |
| 72 | MAP2K3 | 0.53516849 |
| 73 | PTK6 | 0.52295258 |
| 74 | MST4 | 0.52177113 |
| 75 | FGFR3 | 0.51917105 |
| 76 | FYN | 0.51580666 |
| 77 | TESK1 | 0.51077944 |
| 78 | PAK4 | 0.49964447 |
| 79 | STK24 | 0.48085877 |
| 80 | PDPK1 | 0.48072676 |
| 81 | IRAK1 | 0.47562206 |
| 82 | MOS | 0.47372633 |
| 83 | IRAK2 | 0.47119169 |
| 84 | PIK3CG | 0.47041723 |
| 85 | ARAF | 0.46070503 |
| 86 | TNK2 | 0.45792807 |
| 87 | PKN2 | 0.45370428 |
| 88 | DYRK3 | 0.45025574 |
| 89 | LRRK2 | 0.44981705 |
| 90 | TEC | 0.43918138 |
| 91 | CAMKK2 | 0.43179582 |
| 92 | TTN | 0.42964827 |
| 93 | MAP3K10 | 0.42733186 |
| 94 | STK3 | 0.42117779 |
| 95 | RPS6KL1 | 0.41008224 |
| 96 | RPS6KC1 | 0.41008224 |
| 97 | PLK2 | 0.40832568 |
| 98 | MAPK4 | 0.39272322 |
| 99 | MAPKAPK2 | 0.39103955 |
| 100 | RIPK1 | 0.38669156 |
| 101 | PDGFRA | 0.38348041 |
| 102 | PDK1 | 0.38217858 |
| 103 | TRPM7 | 0.36910517 |
| 104 | MAP3K9 | 0.36434408 |
| 105 | TAOK1 | 0.36125652 |
| 106 | CAMK1G | 0.33517306 |
| 107 | SIK3 | 0.32074065 |
| 108 | RPS6KA6 | 0.31866054 |
| 109 | DAPK3 | 0.31034794 |
| 110 | TRIB3 | 0.30589040 |
| 111 | TAOK2 | 0.30363814 |
| 112 | CAMKK1 | 0.29918976 |
| 113 | STK4 | 0.29582672 |
| 114 | MAPK7 | 0.28515815 |
| 115 | DAPK2 | 0.27176485 |
| 116 | PDGFRB | 0.27010398 |
| 117 | IGF1R | 0.26720841 |
| 118 | CDK6 | 0.26219687 |
| 119 | HIPK2 | 0.24951004 |
| 120 | INSR | 0.23234429 |
| 121 | EPHA3 | 0.23111581 |
| 122 | PKN1 | 0.21079238 |
| 123 | GSK3A | 0.20756369 |
| 124 | MARK2 | 0.19928467 |
| 125 | SIK1 | 0.19640932 |
| 126 | RPS6KA2 | 0.16920180 |
| 127 | TGFBR1 | 0.16345450 |
| 128 | PDK2 | 0.15835976 |
| 129 | ICK | 0.15824063 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.90481525 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.78708485 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.17799851 |
| 4 | Legionellosis_Homo sapiens_hsa05134 | 3.07153327 |
| 5 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 3.01518073 |
| 6 | Malaria_Homo sapiens_hsa05144 | 2.64276827 |
| 7 | Pertussis_Homo sapiens_hsa05133 | 2.63399769 |
| 8 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.56217087 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.50458876 |
| 10 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.42263060 |
| 11 | Asthma_Homo sapiens_hsa05310 | 2.37463029 |
| 12 | Tuberculosis_Homo sapiens_hsa05152 | 2.31031243 |
| 13 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.25673758 |
| 14 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.23934148 |
| 15 | African trypanosomiasis_Homo sapiens_hsa05143 | 2.16754665 |
| 16 | Allograft rejection_Homo sapiens_hsa05330 | 2.08216582 |
| 17 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.05883757 |
| 18 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.05860498 |
| 19 | Salmonella infection_Homo sapiens_hsa05132 | 1.98573772 |
| 20 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.94511665 |
| 21 | Lysosome_Homo sapiens_hsa04142 | 1.91598728 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.91163662 |
| 23 | Phagosome_Homo sapiens_hsa04145 | 1.89372545 |
| 24 | Measles_Homo sapiens_hsa05162 | 1.86513270 |
| 25 | Influenza A_Homo sapiens_hsa05164 | 1.83609639 |
| 26 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.73289468 |
| 27 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.59266334 |
| 28 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.55231541 |
| 29 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.48335154 |
| 30 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.45903165 |
| 31 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.44954274 |
| 32 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.41625950 |
| 33 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.37230962 |
| 34 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.26728593 |
| 35 | Amoebiasis_Homo sapiens_hsa05146 | 1.22673881 |
| 36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.19913194 |
| 37 | Prion diseases_Homo sapiens_hsa05020 | 1.19829982 |
| 38 | Shigellosis_Homo sapiens_hsa05131 | 1.17566497 |
| 39 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.16256425 |
| 40 | Other glycan degradation_Homo sapiens_hsa00511 | 1.16216272 |
| 41 | Apoptosis_Homo sapiens_hsa04210 | 1.10666516 |
| 42 | Bladder cancer_Homo sapiens_hsa05219 | 1.05773006 |
| 43 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.05171949 |
| 44 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.04581310 |
| 45 | Hepatitis B_Homo sapiens_hsa05161 | 1.04257518 |
| 46 | Hepatitis C_Homo sapiens_hsa05160 | 1.00153398 |
| 47 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.96912765 |
| 48 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.89275770 |
| 49 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.88820351 |
| 50 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.87444398 |
| 51 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.86184602 |
| 52 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.85828678 |
| 53 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.82888426 |
| 54 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.79845589 |
| 55 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.79073651 |
| 56 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.71358538 |
| 57 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.70369119 |
| 58 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.67551963 |
| 59 | Viral myocarditis_Homo sapiens_hsa05416 | 0.67069770 |
| 60 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.67060601 |
| 61 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.65566964 |
| 62 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.62580849 |
| 63 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.62143179 |
| 64 | Mineral absorption_Homo sapiens_hsa04978 | 0.60346868 |
| 65 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.56543496 |
| 66 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.55403780 |
| 67 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.52405028 |
| 68 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.51105928 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.49162351 |
| 70 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.49125833 |
| 71 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.48742681 |
| 72 | Platelet activation_Homo sapiens_hsa04611 | 0.46766280 |
| 73 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.46473648 |
| 74 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.45510506 |
| 75 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.42534610 |
| 76 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.42067914 |
| 77 | Galactose metabolism_Homo sapiens_hsa00052 | 0.41853461 |
| 78 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.41822807 |
| 79 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.37555084 |
| 80 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.36889213 |
| 81 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.36138853 |
| 82 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.32908487 |
| 83 | Insulin resistance_Homo sapiens_hsa04931 | 0.31944945 |
| 84 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.26846117 |
| 85 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.26052747 |
| 86 | Endocytosis_Homo sapiens_hsa04144 | 0.24764959 |
| 87 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.24547255 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.23943998 |
| 89 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.23660087 |
| 90 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.22365963 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.22165988 |
| 92 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.20857698 |
| 93 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.20498351 |
| 94 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.20134814 |
| 95 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.19464580 |
| 96 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.19160252 |
| 97 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.18766627 |
| 98 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.18721093 |
| 99 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.18037977 |
| 100 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.18016995 |
| 101 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.17553371 |
| 102 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.17178638 |
| 103 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.12556665 |
| 104 | HTLV-I infection_Homo sapiens_hsa05166 | 0.11481318 |
| 105 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.11125995 |
| 106 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.10061075 |
| 107 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.06787080 |
| 108 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.05922442 |
| 109 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.05313556 |
| 110 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.04668809 |
| 111 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.04589039 |

