GPR85

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfation (GO:0051923)6.06286274
2neuron cell-cell adhesion (GO:0007158)6.04264752
3behavioral response to nicotine (GO:0035095)5.43380765
4presynaptic membrane assembly (GO:0097105)5.17241811
5vocalization behavior (GO:0071625)5.17004393
6pyrimidine nucleobase catabolic process (GO:0006208)5.13143898
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99363752
8presynaptic membrane organization (GO:0097090)4.74481835
9cell proliferation in forebrain (GO:0021846)4.68038151
10postsynaptic membrane organization (GO:0001941)4.60971980
11neuron recognition (GO:0008038)4.55514031
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.48944598
13protein localization to synapse (GO:0035418)4.43389289
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.41034608
15regulation of glutamate receptor signaling pathway (GO:1900449)4.40219684
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34382215
17cerebral cortex radially oriented cell migration (GO:0021799)4.32461796
18regulation of glomerulus development (GO:0090192)4.29948586
19synaptic vesicle exocytosis (GO:0016079)4.24775626
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24178487
21neurotransmitter-gated ion channel clustering (GO:0072578)4.17537542
22nucleobase catabolic process (GO:0046113)4.16196669
23water-soluble vitamin biosynthetic process (GO:0042364)4.08591161
24glutamate receptor signaling pathway (GO:0007215)4.04930698
25axonal fasciculation (GO:0007413)4.04060823
26otic vesicle formation (GO:0030916)3.99606450
27regulation of synaptic vesicle exocytosis (GO:2000300)3.96643022
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92112305
29regulation of DNA endoreduplication (GO:0032875)3.91515275
30regulation of phospholipid biosynthetic process (GO:0071071)3.90434264
31startle response (GO:0001964)3.89802754
32synaptic transmission, glutamatergic (GO:0035249)3.86942253
33cell migration in hindbrain (GO:0021535)3.84914650
34central nervous system projection neuron axonogenesis (GO:0021952)3.80285261
35neuron-neuron synaptic transmission (GO:0007270)3.78666478
36positive regulation of synapse assembly (GO:0051965)3.78252783
37locomotory exploration behavior (GO:0035641)3.74547264
38exploration behavior (GO:0035640)3.72397215
39flavonoid metabolic process (GO:0009812)3.68762022
40dendrite morphogenesis (GO:0048813)3.65053051
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.62678696
42regulation of glutamate secretion (GO:0014048)3.60171598
43cellular response to ATP (GO:0071318)3.59001064
44regulation of cell proliferation involved in kidney development (GO:1901722)3.58864609
45cerebellar granule cell differentiation (GO:0021707)3.55308383
46glutamate secretion (GO:0014047)3.52790484
47regulation of collateral sprouting (GO:0048670)3.51551495
48dendritic spine morphogenesis (GO:0060997)3.50687945
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.50667822
50NADH dehydrogenase complex assembly (GO:0010257)3.50667822
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50667822
52parturition (GO:0007567)3.50136208
53kynurenine metabolic process (GO:0070189)3.49328341
54regulation of synaptic vesicle transport (GO:1902803)3.49146066
55negative regulation of systemic arterial blood pressure (GO:0003085)3.47462334
56synapse assembly (GO:0007416)3.46977248
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45888705
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45698889
59protein complex biogenesis (GO:0070271)3.44758068
60tryptophan catabolic process (GO:0006569)3.43544525
61indole-containing compound catabolic process (GO:0042436)3.43544525
62indolalkylamine catabolic process (GO:0046218)3.43544525
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42768749
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.41439550
65positive regulation of cAMP-mediated signaling (GO:0043950)3.39040075
66epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.38096727
67protein polyglutamylation (GO:0018095)3.37454660
68positive regulation of cardiac muscle cell differentiation (GO:2000727)3.36475012
69negative regulation of mast cell activation (GO:0033004)3.32362980
70regulation of synapse structural plasticity (GO:0051823)3.32329978
71transmission of nerve impulse (GO:0019226)3.31781804
72layer formation in cerebral cortex (GO:0021819)3.31415168
73ATP synthesis coupled proton transport (GO:0015986)3.29977261
74energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29977261
75neuronal action potential (GO:0019228)3.29588079
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29006116
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28222058
78synaptic vesicle maturation (GO:0016188)3.22319043
79mitochondrial respiratory chain complex assembly (GO:0033108)3.22023436
80dendrite development (GO:0016358)3.21840350
81negative regulation of response to food (GO:0032096)3.20686227
82negative regulation of appetite (GO:0032099)3.20686227
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.20255618
84regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.19022594
85synaptic vesicle endocytosis (GO:0048488)3.17600377
86regulation of respiratory system process (GO:0044065)3.16897511
87regulation of postsynaptic membrane potential (GO:0060078)3.15830823
88neuronal action potential propagation (GO:0019227)3.15332337
89pharyngeal system development (GO:0060037)3.14076141
90neurotransmitter secretion (GO:0007269)3.12980130
91long-term synaptic potentiation (GO:0060291)3.12563717
92purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.11859052
933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.11859052
94membrane depolarization during action potential (GO:0086010)3.11471020
95positive regulation of synapse maturation (GO:0090129)3.09175327
96regulation of synaptic transmission, glutamatergic (GO:0051966)3.08675724
97regulation of neuronal synaptic plasticity (GO:0048168)3.07941965
98glycerophospholipid catabolic process (GO:0046475)3.07106892
99auditory behavior (GO:0031223)3.07104963
100regulation of synapse assembly (GO:0051963)3.07076953
101establishment of mitochondrion localization (GO:0051654)3.06574074
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06551944
103positive regulation of potassium ion transmembrane transport (GO:1901381)3.05272920
104central nervous system neuron axonogenesis (GO:0021955)3.05121403
105negative regulation of axon guidance (GO:1902668)3.04415198
106regulation of dendritic spine morphogenesis (GO:0061001)3.04374189
107axon extension (GO:0048675)3.03572485
108regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03379070
109indolalkylamine metabolic process (GO:0006586)3.03120202
110mechanosensory behavior (GO:0007638)3.00769235
111limb bud formation (GO:0060174)3.00527996
112negative regulation of transcription regulatory region DNA binding (GO:2000678)3.00059476
113serotonin metabolic process (GO:0042428)2.99651842
114reflex (GO:0060004)2.99497514
115gamma-aminobutyric acid transport (GO:0015812)2.98372908
116negative regulation of dendrite development (GO:2000171)2.97978833
117retinal ganglion cell axon guidance (GO:0031290)2.97952366
118regulation of synapse maturation (GO:0090128)2.96591931
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96514139
120positive regulation of metanephros development (GO:0072216)2.96034573
121long-term memory (GO:0007616)2.95701779
122positive regulation of amino acid transport (GO:0051957)2.95340662
123positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95329474
124positive regulation of membrane potential (GO:0045838)2.94765447
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94358341
126dorsal/ventral axis specification (GO:0009950)2.94093935
127regulation of vesicle fusion (GO:0031338)2.93632854
128regulation of neurotransmitter secretion (GO:0046928)2.92955904
129negative regulation of neurotransmitter transport (GO:0051589)2.91931044
130regulation of posttranscriptional gene silencing (GO:0060147)2.91576954
131regulation of gene silencing by miRNA (GO:0060964)2.91576954
132regulation of gene silencing by RNA (GO:0060966)2.91576954
133long-chain fatty acid biosynthetic process (GO:0042759)2.90646240
134tryptophan metabolic process (GO:0006568)2.90350016
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.89587167
136response to auditory stimulus (GO:0010996)2.89487910
137behavioral fear response (GO:0001662)2.88922616
138behavioral defense response (GO:0002209)2.88922616
139regulation of action potential (GO:0098900)2.86478659
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84915664
141indole-containing compound metabolic process (GO:0042430)2.83779139
142negative chemotaxis (GO:0050919)2.82997650
143learning (GO:0007612)2.82951648
144synapse organization (GO:0050808)2.82006245
145glycosphingolipid biosynthetic process (GO:0006688)2.81867335
146regulation of respiratory gaseous exchange (GO:0043576)2.79566741
147N-acetylglucosamine metabolic process (GO:0006044)2.78951387
148regulation of synapse organization (GO:0050807)2.76585387
149regulation of synaptic transmission, GABAergic (GO:0032228)2.76504626
150positive regulation of neurotransmitter secretion (GO:0001956)2.76324725
151response to histamine (GO:0034776)2.74298367
152photoreceptor cell development (GO:0042461)2.73857164
153neurotransmitter transport (GO:0006836)2.73359076
154fear response (GO:0042596)2.70831739
155regulation of synaptic plasticity (GO:0048167)2.70118662
156negative regulation of microtubule polymerization (GO:0031115)2.70033920
157positive regulation of protein autophosphorylation (GO:0031954)2.69800918
158somite development (GO:0061053)2.69235979
159adult behavior (GO:0030534)2.68039398
160righting reflex (GO:0060013)2.67663461
161negative regulation of axonogenesis (GO:0050771)2.66763138
162membrane depolarization (GO:0051899)2.66736476
163DNA deamination (GO:0045006)2.64912385
164forebrain neuron development (GO:0021884)2.63783539
165protein neddylation (GO:0045116)2.62998872
166primary amino compound metabolic process (GO:1901160)2.62058142
167eye photoreceptor cell development (GO:0042462)2.61058169
168positive regulation of fatty acid beta-oxidation (GO:0032000)2.60925101
169cellular anion homeostasis (GO:0030002)2.59952867
170respiratory electron transport chain (GO:0022904)2.59475463
171electron transport chain (GO:0022900)2.59459487
172detection of light stimulus involved in sensory perception (GO:0050962)2.58942666
173detection of light stimulus involved in visual perception (GO:0050908)2.58942666
174positive regulation of protein homodimerization activity (GO:0090073)2.58908027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40246073
2GBX2_23144817_ChIP-Seq_PC3_Human4.24293632
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95882562
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87482798
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86733417
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69267387
7TAF15_26573619_Chip-Seq_HEK293_Human2.53579801
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51033804
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.48432487
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42567031
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39651416
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37071447
13REST_21632747_ChIP-Seq_MESCs_Mouse2.35858080
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34783147
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34014921
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31820642
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31820642
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31281040
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.24577799
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15735811
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13989414
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12823538
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.11943298
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11636471
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08472092
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04417466
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98443926
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.97799776
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95247159
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.95025551
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94438534
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88520592
33P300_19829295_ChIP-Seq_ESCs_Human1.88163836
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87338712
35IGF1R_20145208_ChIP-Seq_DFB_Human1.85587205
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84364010
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84148946
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79526158
39RNF2_27304074_Chip-Seq_NSC_Mouse1.77832103
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.74056619
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70815619
42SMAD4_21799915_ChIP-Seq_A2780_Human1.68528650
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65800757
44AR_21572438_ChIP-Seq_LNCaP_Human1.64464360
45DROSHA_22980978_ChIP-Seq_HELA_Human1.63246883
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61694463
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61270436
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61261534
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60349466
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59964623
51* RARB_27405468_Chip-Seq_BRAIN_Mouse1.58708303
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57986313
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56746145
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54723981
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.54449893
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53273353
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52130115
58CBP_20019798_ChIP-Seq_JUKART_Human1.52130115
59VDR_22108803_ChIP-Seq_LS180_Human1.51939213
60FUS_26573619_Chip-Seq_HEK293_Human1.50760928
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50044308
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47043894
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.44415572
64* ER_23166858_ChIP-Seq_MCF-7_Human1.44313703
65ZNF274_21170338_ChIP-Seq_K562_Hela1.43302001
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.43199051
67BCAT_22108803_ChIP-Seq_LS180_Human1.41650189
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37075224
69IRF1_19129219_ChIP-ChIP_H3396_Human1.33493158
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33285924
71AR_25329375_ChIP-Seq_VCAP_Human1.33251427
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27882319
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25753209
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22957264
75STAT3_23295773_ChIP-Seq_U87_Human1.22899012
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22270621
77MYC_18940864_ChIP-ChIP_HL60_Human1.22172091
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.22031520
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21546562
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21321327
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.20939833
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.20232852
83TCF4_23295773_ChIP-Seq_U87_Human1.19666218
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19247077
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19158313
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19158313
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18808379
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.18507534
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.18309133
90RUNX2_22187159_ChIP-Seq_PCA_Human1.17567786
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16525615
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12515468
93TP53_18474530_ChIP-ChIP_U2OS_Human1.11170525
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10654390
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.09624354
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.09345256
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08281670
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08041822
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07708964
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.07700435
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.07686998
102AHR_22903824_ChIP-Seq_MCF-7_Human1.07101014
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06852960
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.06326374
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06316811
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06070303
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05676273
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05377691
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.04788201
110JUN_21703547_ChIP-Seq_K562_Human1.03614917
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03111440
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02982225
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.02384108
114TCF4_22108803_ChIP-Seq_LS180_Human1.01391527
115* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00656084
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.99910187
117P53_22387025_ChIP-Seq_ESCs_Mouse0.99857206
118KDM2B_26808549_Chip-Seq_REH_Human0.99123428
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98735671
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98499073
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.98149689
122AR_19668381_ChIP-Seq_PC3_Human0.96515752
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95542920
124EWS_26573619_Chip-Seq_HEK293_Human0.93768566
125* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93736393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.22136148
2MP0004859_abnormal_synaptic_plasticity4.61730468
3MP0004270_analgesia3.60572148
4MP0003635_abnormal_synaptic_transmissio3.46459138
5* MP0002063_abnormal_learning/memory/cond3.02987727
6MP0009745_abnormal_behavioral_response2.99490739
7MP0000778_abnormal_nervous_system2.84840944
8MP0005423_abnormal_somatic_nervous2.78364872
9MP0001968_abnormal_touch/_nociception2.72918388
10MP0002064_seizures2.71136572
11MP0002572_abnormal_emotion/affect_behav2.65932659
12MP0002734_abnormal_mechanical_nocicepti2.64139513
13MP0009046_muscle_twitch2.63673682
14MP0006276_abnormal_autonomic_nervous2.58503512
15MP0001486_abnormal_startle_reflex2.46946080
16MP0001188_hyperpigmentation2.44440175
17MP0002735_abnormal_chemical_nociception2.38423689
18MP0002736_abnormal_nociception_after2.37110003
19MP0002272_abnormal_nervous_system2.31229473
20MP0002160_abnormal_reproductive_system2.22014215
21MP0003787_abnormal_imprinting2.15771992
22MP0002184_abnormal_innervation2.14520031
23MP0000049_abnormal_middle_ear2.14283574
24MP0001440_abnormal_grooming_behavior2.11547613
25MP0002822_catalepsy2.09260758
26MP0005645_abnormal_hypothalamus_physiol2.05068044
27MP0001529_abnormal_vocalization2.02753873
28MP0002067_abnormal_sensory_capabilities1.95934897
29MP0004145_abnormal_muscle_electrophysio1.94234649
30MP0002733_abnormal_thermal_nociception1.89022236
31MP0001984_abnormal_olfaction1.88102512
32MP0002557_abnormal_social/conspecific_i1.87556969
33MP0005386_behavior/neurological_phenoty1.87089165
34MP0004924_abnormal_behavior1.87089165
35MP0001970_abnormal_pain_threshold1.79835910
36MP0008872_abnormal_physiological_respon1.75876930
37MP0001905_abnormal_dopamine_level1.70303722
38MP0001501_abnormal_sleep_pattern1.68731703
39MP0008877_abnormal_DNA_methylation1.67856588
40MP0005646_abnormal_pituitary_gland1.64300182
41MP0004811_abnormal_neuron_physiology1.60818178
42MP0004742_abnormal_vestibular_system1.60688306
43MP0010386_abnormal_urinary_bladder1.59426807
44MP0005389_reproductive_system_phenotype1.53088382
45MP0000955_abnormal_spinal_cord1.51706454
46MP0002882_abnormal_neuron_morphology1.50971914
47MP0003329_amyloid_beta_deposits1.50902834
48MP0009780_abnormal_chondrocyte_physiolo1.49648907
49MP0009250_abnormal_appendicular_skeleto1.48910402
50MP0004858_abnormal_nervous_system1.41378182
51MP0002066_abnormal_motor_capabilities/c1.39414862
52MP0000015_abnormal_ear_pigmentation1.38025121
53MP0004142_abnormal_muscle_tone1.32608960
54MP0005499_abnormal_olfactory_system1.32233472
55MP0005394_taste/olfaction_phenotype1.32233472
56MP0008569_lethality_at_weaning1.28416329
57MP0003122_maternal_imprinting1.27638175
58MP0000631_abnormal_neuroendocrine_gland1.27574934
59MP0003646_muscle_fatigue1.27027114
60MP0005171_absent_coat_pigmentation1.26870031
61MP0003195_calcinosis1.26111622
62MP0004133_heterotaxia1.24576840
63* MP0002152_abnormal_brain_morphology1.22816627
64MP0002638_abnormal_pupillary_reflex1.19435354
65MP0006292_abnormal_olfactory_placode1.17465837
66MP0000569_abnormal_digit_pigmentation1.17394826
67MP0001502_abnormal_circadian_rhythm1.15304076
68MP0002938_white_spotting1.14787132
69MP0003879_abnormal_hair_cell1.12517780
70MP0008789_abnormal_olfactory_epithelium1.12369294
71MP0002751_abnormal_autonomic_nervous1.11324479
72MP0002102_abnormal_ear_morphology1.10128041
73MP0005409_darkened_coat_color1.09312469
74MP0002138_abnormal_hepatobiliary_system1.09245642
75MP0000678_abnormal_parathyroid_gland1.09002951
76MP0002876_abnormal_thyroid_physiology1.06979257
77MP0002752_abnormal_somatic_nervous1.06214028
78MP0000920_abnormal_myelination1.05642964
79MP0005551_abnormal_eye_electrophysiolog1.03432601
80MP0002909_abnormal_adrenal_gland0.98665110
81MP0004885_abnormal_endolymph0.97931399
82MP0005084_abnormal_gallbladder_morpholo0.96373300
83MP0001963_abnormal_hearing_physiology0.95975515
84MP0002229_neurodegeneration0.95930783
85MP0003631_nervous_system_phenotype0.95726613
86MP0003937_abnormal_limbs/digits/tail_de0.95394999
87MP0003634_abnormal_glial_cell0.95236879
88MP0009379_abnormal_foot_pigmentation0.93474109
89MP0003011_delayed_dark_adaptation0.91823665
90MP0003633_abnormal_nervous_system0.91572202
91MP0002249_abnormal_larynx_morphology0.90737145
92MP0000026_abnormal_inner_ear0.89913168
93MP0002069_abnormal_eating/drinking_beha0.88576173
94MP0002928_abnormal_bile_duct0.86217975
95MP0001986_abnormal_taste_sensitivity0.85875999
96MP0004215_abnormal_myocardial_fiber0.85748208
97MP0008875_abnormal_xenobiotic_pharmacok0.85028654
98MP0004130_abnormal_muscle_cell0.84791964
99MP0003861_abnormal_nervous_system0.83526439
100MP0002837_dystrophic_cardiac_calcinosis0.81374224
101MP0001919_abnormal_reproductive_system0.80728936
102MP0000372_irregular_coat_pigmentation0.80387249
103MP0003632_abnormal_nervous_system0.79887388
104MP0005248_abnormal_Harderian_gland0.78810227
105MP0003567_abnormal_fetal_cardiomyocyte0.78192178
106MP0005410_abnormal_fertilization0.77643057
107MP0003942_abnormal_urinary_system0.77265260
108MP0001177_atelectasis0.75607934
109MP0003938_abnormal_ear_development0.75294393
110MP0003638_abnormal_response/metabolism_0.74292889
111MP0000751_myopathy0.73419586
112MP0003385_abnormal_body_wall0.72707692
113MP0000613_abnormal_salivary_gland0.71685036
114MP0003303_peritoneal_inflammation0.71333909
115MP0003690_abnormal_glial_cell0.69161982
116MP0001664_abnormal_digestion0.67830814
117MP0004085_abnormal_heartbeat0.67807887
118MP0000604_amyloidosis0.67054382
119MP0001485_abnormal_pinna_reflex0.65293381
120MP0002653_abnormal_ependyma_morphology0.63931448
121MP0003121_genomic_imprinting0.63459756
122MP0005535_abnormal_body_temperature0.62080781
123MP0006072_abnormal_retinal_apoptosis0.61848507
124MP0001299_abnormal_eye_distance/0.60687575
125MP0001943_abnormal_respiration0.60330666
126MP0005195_abnormal_posterior_eye0.60034287
127MP0004134_abnormal_chest_morphology0.59932609
128MP0005253_abnormal_eye_physiology0.58004782
129MP0000538_abnormal_urinary_bladder0.56880385
130MP0010770_preweaning_lethality0.56363026

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.08902473
2Epileptic encephalopathy (HP:0200134)4.71293350
3Pendular nystagmus (HP:0012043)4.51066553
4Febrile seizures (HP:0002373)4.42804922
5Atonic seizures (HP:0010819)4.40208970
6Myokymia (HP:0002411)4.38411379
7Hyperventilation (HP:0002883)4.30997378
8Focal seizures (HP:0007359)4.28285668
9Septo-optic dysplasia (HP:0100842)4.08583704
10Pancreatic cysts (HP:0001737)4.04090388
11Pancreatic fibrosis (HP:0100732)4.01347924
12True hermaphroditism (HP:0010459)3.99240484
13Progressive cerebellar ataxia (HP:0002073)3.83593102
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.76170729
15Broad-based gait (HP:0002136)3.61282097
16Drooling (HP:0002307)3.56215027
17Excessive salivation (HP:0003781)3.56215027
18Abolished electroretinogram (ERG) (HP:0000550)3.50970349
19Gait imbalance (HP:0002141)3.41191033
20Limb dystonia (HP:0002451)3.34700907
21Abnormality of the corticospinal tract (HP:0002492)3.33830056
22Absence seizures (HP:0002121)3.29444640
23Amblyopia (HP:0000646)3.29367947
24Methylmalonic acidemia (HP:0002912)3.17954098
25Hypoplastic pelvis (HP:0008839)3.09601946
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.09342018
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.09342018
28Dialeptic seizures (HP:0011146)3.08130716
29Protruding tongue (HP:0010808)3.07268061
303-Methylglutaconic aciduria (HP:0003535)3.03744313
31Visual hallucinations (HP:0002367)3.03473350
32Decreased central vision (HP:0007663)3.00749156
33Abnormal hair whorl (HP:0010721)2.99420454
34Molar tooth sign on MRI (HP:0002419)2.92373323
35Abnormality of midbrain morphology (HP:0002418)2.92373323
36Polyphagia (HP:0002591)2.91818884
37Generalized tonic-clonic seizures (HP:0002069)2.91312516
38Supranuclear gaze palsy (HP:0000605)2.86547136
39Poor eye contact (HP:0000817)2.80133456
40Nephronophthisis (HP:0000090)2.79316366
41Confusion (HP:0001289)2.77599218
42Progressive inability to walk (HP:0002505)2.77280158
43Furrowed tongue (HP:0000221)2.75784991
44Medial flaring of the eyebrow (HP:0010747)2.75581765
45Congenital primary aphakia (HP:0007707)2.74592992
46Nephrogenic diabetes insipidus (HP:0009806)2.74112088
47Epileptiform EEG discharges (HP:0011182)2.73296741
48Optic nerve hypoplasia (HP:0000609)2.73030309
49Lissencephaly (HP:0001339)2.72209582
50Abnormal rod and cone electroretinograms (HP:0008323)2.67206378
51Increased corneal curvature (HP:0100692)2.66121850
52Keratoconus (HP:0000563)2.66121850
53Blue irides (HP:0000635)2.63448815
54Absent speech (HP:0001344)2.62037373
55Cystic liver disease (HP:0006706)2.61756990
56Hypoplasia of the brainstem (HP:0002365)2.60982560
57Aplasia/Hypoplasia of the brainstem (HP:0007362)2.60982560
58Severe visual impairment (HP:0001141)2.59394500
59Mutism (HP:0002300)2.58860590
60EEG with generalized epileptiform discharges (HP:0011198)2.58727953
61Congenital stationary night blindness (HP:0007642)2.58703388
62Neurofibrillary tangles (HP:0002185)2.57320904
63Methylmalonic aciduria (HP:0012120)2.56954941
64Action tremor (HP:0002345)2.51701931
65Abnormality of salivation (HP:0100755)2.51700211
66Conjunctival hamartoma (HP:0100780)2.51635676
67Mitochondrial inheritance (HP:0001427)2.51219360
68Termporal pattern (HP:0011008)2.50213555
69Insidious onset (HP:0003587)2.50213555
70Progressive macrocephaly (HP:0004481)2.49545386
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.49284104
72Asplenia (HP:0001746)2.49144704
73Stenosis of the external auditory canal (HP:0000402)2.48665040
74Hypsarrhythmia (HP:0002521)2.48526251
75Exotropia (HP:0000577)2.48102622
76Ankle clonus (HP:0011448)2.47252669
77Gaze-evoked nystagmus (HP:0000640)2.47089623
78Abnormal eating behavior (HP:0100738)2.44407904
79Inability to walk (HP:0002540)2.42074452
80Esotropia (HP:0000565)2.41141233
81Failure to thrive in infancy (HP:0001531)2.40740888
82Abnormal mitochondria in muscle tissue (HP:0008316)2.39808705
83Hemiparesis (HP:0001269)2.39057733
84Specific learning disability (HP:0001328)2.38367399
85Dysdiadochokinesis (HP:0002075)2.35802703
86Impaired social interactions (HP:0000735)2.34828796
87Abnormal social behavior (HP:0012433)2.34828796
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.33091991
89Cerebral inclusion bodies (HP:0100314)2.31954365
90Sclerocornea (HP:0000647)2.29987204
91Congenital, generalized hypertrichosis (HP:0004540)2.29135447
92Spastic gait (HP:0002064)2.27720110
93Urinary bladder sphincter dysfunction (HP:0002839)2.27497774
94Truncal ataxia (HP:0002078)2.27376246
95Small hand (HP:0200055)2.26921767
96Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26752303
97Vaginal atresia (HP:0000148)2.23865108
98Dysmetria (HP:0001310)2.21440407
99Genital tract atresia (HP:0001827)2.20914407
100Akinesia (HP:0002304)2.19766115
101Impaired vibration sensation in the lower limbs (HP:0002166)2.18072038
102Increased CSF lactate (HP:0002490)2.17462547
103Aplasia/Hypoplasia of the tongue (HP:0010295)2.16676480
104Urinary urgency (HP:0000012)2.14365806
105Stereotypic behavior (HP:0000733)2.14329579
106Chronic hepatic failure (HP:0100626)2.14157679
107Hemiplegia (HP:0002301)2.13391912
108Inappropriate behavior (HP:0000719)2.12358279
109Anxiety (HP:0000739)2.12290765
110Male pseudohermaphroditism (HP:0000037)2.11572361
111Abnormality of the renal medulla (HP:0100957)2.11004760
112Anencephaly (HP:0002323)2.10810355
113Acute encephalopathy (HP:0006846)2.09956733
114Pheochromocytoma (HP:0002666)2.07551413
115Abnormality of the proximal phalanges of the hand (HP:0009834)2.07060196
116Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06380422
117Sleep apnea (HP:0010535)2.05519148
118Long nose (HP:0003189)2.04748161
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.04504999
120Dynein arm defect of respiratory motile cilia (HP:0012255)2.04220455
121Absent/shortened dynein arms (HP:0200106)2.04220455
122Fetal akinesia sequence (HP:0001989)2.04188635
123Morphological abnormality of the middle ear (HP:0008609)2.03657298
124Absent septum pellucidum (HP:0001331)2.02475546
125Poor coordination (HP:0002370)2.02318535
126Attenuation of retinal blood vessels (HP:0007843)2.02250242
127Genetic anticipation (HP:0003743)2.00961033
128Amyotrophic lateral sclerosis (HP:0007354)2.00257575
129Hamartoma of the eye (HP:0010568)1.99216592
130Scanning speech (HP:0002168)1.99123133
131Chorioretinal atrophy (HP:0000533)1.97947217
132Abnormality of binocular vision (HP:0011514)1.97763993
133Diplopia (HP:0000651)1.97763993
134Lower limb muscle weakness (HP:0007340)1.96075712
135Short tibia (HP:0005736)1.94759851
136Abnormality of homocysteine metabolism (HP:0010919)1.94552011
137Homocystinuria (HP:0002156)1.94552011
138Hepatocellular necrosis (HP:0001404)1.94547953
139Congenital sensorineural hearing impairment (HP:0008527)1.94344084
140Increased hepatocellular lipid droplets (HP:0006565)1.93919774
141Thickened helices (HP:0000391)1.93429311
142Goiter (HP:0000853)1.93121742
143Pachygyria (HP:0001302)1.92970390
144Aplasia/Hypoplasia of the lens (HP:0008063)1.91727039
145Agitation (HP:0000713)1.90858009
146Abnormality of the phalanges of the 5th finger (HP:0004213)1.90444606
147Impaired smooth pursuit (HP:0007772)1.89070699
148Incomplete penetrance (HP:0003829)1.88384277
149Depression (HP:0000716)1.88252760
150Morphological abnormality of the pyramidal tract (HP:0002062)1.87730193
151Porencephaly (HP:0002132)1.87313983
152Gastroesophageal reflux (HP:0002020)1.85954289
153Narrow nasal bridge (HP:0000446)1.84350183
154Oral leukoplakia (HP:0002745)1.82385766
155Hypothermia (HP:0002045)1.81436321
156Hyperthyroidism (HP:0000836)1.81053786
157Fibular aplasia (HP:0002990)1.80899883
158Abnormal number of erythroid precursors (HP:0012131)1.79772925
159Lipid accumulation in hepatocytes (HP:0006561)1.79302320
160Abnormality of cells of the erythroid lineage (HP:0012130)1.79119212
161Abnormality of the renal cortex (HP:0011035)1.77764962
162Symphalangism affecting the phalanges of the hand (HP:0009773)1.77474080
163Postaxial foot polydactyly (HP:0001830)1.77222917
164Renal Fanconi syndrome (HP:0001994)1.76285511
165Abnormality of the renal collecting system (HP:0004742)1.75604712
166Widely spaced teeth (HP:0000687)1.75528365
167Retinal dysplasia (HP:0007973)1.74643514
168Neuroendocrine neoplasm (HP:0100634)1.74026126
169Abnormality of ocular smooth pursuit (HP:0000617)1.73921977
170Abnormal ciliary motility (HP:0012262)1.73272569
171Intellectual disability, severe (HP:0010864)1.71448694
172Acute necrotizing encephalopathy (HP:0006965)1.70882979
173Osteomalacia (HP:0002749)1.70169229
174Poor suck (HP:0002033)1.69866918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.35590590
2CASK5.16782788
3NTRK33.51915261
4EPHA43.01469161
5FRK2.88456420
6GRK12.83015060
7MAP2K72.56582194
8STK162.24654444
9MAP3K42.24617632
10MAPK132.23217778
11PRPF4B2.20364174
12MINK12.14259393
13NTRK21.96515566
14DYRK21.96232325
15MAP4K21.94330051
16MAP3K121.88257703
17MAP3K91.78819118
18DAPK21.78221462
19PLK21.65973559
20BCR1.63897544
21RIPK41.60314024
22TNIK1.58012572
23TAOK31.53306100
24BCKDK1.46661799
25NUAK11.46352185
26AKT31.43446984
27KSR11.42037875
28PAK61.41292296
29UHMK11.41168492
30PNCK1.37025311
31YES11.35985280
32SGK2231.32805894
33SGK4941.32805894
34SIK31.31984041
35WNK31.31272160
36ZAK1.30606839
37PRKD21.30042525
38CDK51.28832573
39OXSR11.27122562
40BMPR1B1.26514802
41TLK11.26000687
42VRK11.25676487
43PKN11.20853755
44MAP2K41.19168844
45CSNK1G21.15274552
46CDC71.14538113
47SGK21.12058078
48CDK191.11087107
49SIK21.10674198
50ERBB31.09954806
51BMPR21.07082417
52CAMK2A1.07020589
53DAPK11.04097221
54CAMK2B1.00521837
55GRK50.99540250
56PRKCG0.98743919
57CSNK1G30.96889860
58FGR0.96720720
59CSNK1A1L0.96234905
60ADRBK20.93781939
61DYRK1A0.92595740
62STK390.92552035
63PHKG10.92151865
64PHKG20.92151865
65VRK20.89947434
66MAPKAPK50.88173836
67GRK70.84277212
68TAF10.83973831
69NME10.80435556
70PRKCE0.78325046
71FES0.76916012
72CDK180.74831406
73LIMK10.73310606
74TIE10.72435173
75CDK140.71806474
76CSNK1A10.71067359
77ACVR1B0.70727813
78TXK0.70292284
79NTRK10.69289301
80IRAK20.67800061
81ERBB20.66988165
82CDK150.66624563
83DYRK30.65258700
84ADRBK10.60833165
85MARK20.60716524
86WNK40.60697404
87RPS6KA50.60130712
88MST40.59766330
89RPS6KA20.59532541
90SGK10.58775469
91BLK0.57551044
92PAK30.56478943
93CSNK1G10.56229706
94ICK0.55825511
95SGK30.54958527
96CDK11A0.54631876
97ARAF0.53687279
98TRIM280.53432518
99ROCK20.52625202
100MUSK0.51739629
101CAMK2D0.50331628
102PRKCA0.49098204
103EPHA30.48990687
104KSR20.47890573
105AURKA0.46651754
106CDK30.46545274
107CAMK10.46178310
108PRKD30.46065850
109PRKCZ0.45964446
110CSNK1D0.45640045
111CLK10.45120792
112ABL20.44588314
113MATK0.43903495
114BRAF0.43513273
115PRKG10.43508679
116INSRR0.43381636
117PTK2B0.42551270
118STK110.41954803
119PRKCH0.41322602
120MAPK40.41205684
121PINK10.40296979
122PRKCI0.39647348
123CAMKK20.38339515
124IGF1R0.36621391
125CAMK40.36488019
126PRKACA0.36276916
127PLK40.35356999
128MAP2K10.35167255
129EIF2AK20.35166000
130CSNK1E0.35121886
131FYN0.35096474
132PRKCQ0.34886609
133TEC0.34749283
134WNK10.34422734
135ERBB40.34393055
136CAMK2G0.34156041
137CCNB10.33733594
138CAMKK10.33102999
139TYRO30.32963592
140RPS6KA30.32887861
141PRKCB0.31336498

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08809585
2Synaptic vesicle cycle_Homo sapiens_hsa047213.01047187
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75341701
4GABAergic synapse_Homo sapiens_hsa047272.58148308
5Glutamatergic synapse_Homo sapiens_hsa047242.51743843
6Morphine addiction_Homo sapiens_hsa050322.50185804
7Circadian entrainment_Homo sapiens_hsa047132.43177447
8Long-term potentiation_Homo sapiens_hsa047202.26367446
9Olfactory transduction_Homo sapiens_hsa047402.20966242
10Collecting duct acid secretion_Homo sapiens_hsa049662.18993727
11Serotonergic synapse_Homo sapiens_hsa047262.10892036
12Dopaminergic synapse_Homo sapiens_hsa047282.08444835
13Protein export_Homo sapiens_hsa030602.04612300
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03453873
15Amphetamine addiction_Homo sapiens_hsa050312.02283676
16Taste transduction_Homo sapiens_hsa047422.01609871
17Ribosome_Homo sapiens_hsa030101.99099593
18Axon guidance_Homo sapiens_hsa043601.94696725
19Long-term depression_Homo sapiens_hsa047301.84120838
20Cholinergic synapse_Homo sapiens_hsa047251.83675538
21Homologous recombination_Homo sapiens_hsa034401.80712352
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65619583
23Renin secretion_Homo sapiens_hsa049241.61938946
24Salivary secretion_Homo sapiens_hsa049701.61276047
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59174253
26Cocaine addiction_Homo sapiens_hsa050301.57819260
27Chemical carcinogenesis_Homo sapiens_hsa052041.55651691
28Insulin secretion_Homo sapiens_hsa049111.51977914
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49216986
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47785678
31Basal transcription factors_Homo sapiens_hsa030221.42748052
32Oxidative phosphorylation_Homo sapiens_hsa001901.41739977
33Vibrio cholerae infection_Homo sapiens_hsa051101.36513860
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33164076
35Calcium signaling pathway_Homo sapiens_hsa040201.32983471
36Phototransduction_Homo sapiens_hsa047441.30877357
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28291571
38Oxytocin signaling pathway_Homo sapiens_hsa049211.27957105
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27392874
40Sulfur metabolism_Homo sapiens_hsa009201.26404353
41Alzheimers disease_Homo sapiens_hsa050101.26358662
42Gap junction_Homo sapiens_hsa045401.25856673
43Gastric acid secretion_Homo sapiens_hsa049711.25521628
44ErbB signaling pathway_Homo sapiens_hsa040121.24919980
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.23424801
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22433708
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20623010
48RNA polymerase_Homo sapiens_hsa030201.20427726
49Caffeine metabolism_Homo sapiens_hsa002321.20135908
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19340502
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18344815
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14559897
53Rheumatoid arthritis_Homo sapiens_hsa053231.14263444
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13285552
55Linoleic acid metabolism_Homo sapiens_hsa005911.11389184
56GnRH signaling pathway_Homo sapiens_hsa049121.10296026
57Retinol metabolism_Homo sapiens_hsa008301.06933569
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06572207
59Vitamin digestion and absorption_Homo sapiens_hsa049771.05653249
60Type I diabetes mellitus_Homo sapiens_hsa049401.02440216
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01740718
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99705477
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97253596
64Tryptophan metabolism_Homo sapiens_hsa003800.95994100
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95735540
66Parkinsons disease_Homo sapiens_hsa050120.95178301
67Phagosome_Homo sapiens_hsa041450.94729987
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.93934399
69Fanconi anemia pathway_Homo sapiens_hsa034600.93824246
70Selenocompound metabolism_Homo sapiens_hsa004500.93272505
71Type II diabetes mellitus_Homo sapiens_hsa049300.92063041
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91494576
73Nitrogen metabolism_Homo sapiens_hsa009100.91305480
74cAMP signaling pathway_Homo sapiens_hsa040240.89860740
75Cardiac muscle contraction_Homo sapiens_hsa042600.88790350
76Estrogen signaling pathway_Homo sapiens_hsa049150.86202972
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85130478
78Endometrial cancer_Homo sapiens_hsa052130.84465870
79Glioma_Homo sapiens_hsa052140.83774617
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83337890
81RNA degradation_Homo sapiens_hsa030180.82512677
82Nucleotide excision repair_Homo sapiens_hsa034200.81577745
83Melanogenesis_Homo sapiens_hsa049160.81244081
84Systemic lupus erythematosus_Homo sapiens_hsa053220.80908756
85Dorso-ventral axis formation_Homo sapiens_hsa043200.77419876
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75474178
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74683066
88Ras signaling pathway_Homo sapiens_hsa040140.74108040
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73761654
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73734843
91African trypanosomiasis_Homo sapiens_hsa051430.73357175
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.72211285
93MAPK signaling pathway_Homo sapiens_hsa040100.71475803
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68349756
95Renal cell carcinoma_Homo sapiens_hsa052110.66586266
96Alcoholism_Homo sapiens_hsa050340.65740851
97Huntingtons disease_Homo sapiens_hsa050160.65696869
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65387906
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64137439
100Basal cell carcinoma_Homo sapiens_hsa052170.60653709
101Butanoate metabolism_Homo sapiens_hsa006500.59074277
102Prion diseases_Homo sapiens_hsa050200.57940319
103Colorectal cancer_Homo sapiens_hsa052100.56955617
104Ether lipid metabolism_Homo sapiens_hsa005650.55596648
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.55186056
106Chemokine signaling pathway_Homo sapiens_hsa040620.53834692
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.52772212
108Choline metabolism in cancer_Homo sapiens_hsa052310.51547970
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51303799
110Wnt signaling pathway_Homo sapiens_hsa043100.51199290
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.50686592
112Steroid biosynthesis_Homo sapiens_hsa001000.49626348
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.49379930
114Regulation of autophagy_Homo sapiens_hsa041400.49105851
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.48766394
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47547312
117Proteasome_Homo sapiens_hsa030500.43957323
118Mineral absorption_Homo sapiens_hsa049780.43810484
119Glycerolipid metabolism_Homo sapiens_hsa005610.42736644
120Salmonella infection_Homo sapiens_hsa051320.41809158
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41352516
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41128630
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41120035
124Graft-versus-host disease_Homo sapiens_hsa053320.40947918
125Rap1 signaling pathway_Homo sapiens_hsa040150.40214685
126Pancreatic secretion_Homo sapiens_hsa049720.39222897
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37668117
128Dilated cardiomyopathy_Homo sapiens_hsa054140.37531679
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37022739
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36513756
131Allograft rejection_Homo sapiens_hsa053300.36491047
132Sphingolipid metabolism_Homo sapiens_hsa006000.36458215
133Peroxisome_Homo sapiens_hsa041460.36078391
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35759950
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35519223
136Ovarian steroidogenesis_Homo sapiens_hsa049130.35479757
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35162989
138Autoimmune thyroid disease_Homo sapiens_hsa053200.33664060
139Melanoma_Homo sapiens_hsa052180.33094540
140Metabolic pathways_Homo sapiens_hsa011000.32893167
141Purine metabolism_Homo sapiens_hsa002300.32244219
142Hedgehog signaling pathway_Homo sapiens_hsa043400.31416904
143Inositol phosphate metabolism_Homo sapiens_hsa005620.30311276
144Tuberculosis_Homo sapiens_hsa051520.29853405
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26902269
146VEGF signaling pathway_Homo sapiens_hsa043700.26810301
147Oocyte meiosis_Homo sapiens_hsa041140.26375696

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