GPR87

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.72511455
2multicellular organismal water homeostasis (GO:0050891)8.33183148
3cell-substrate junction assembly (GO:0007044)7.41828518
4water homeostasis (GO:0030104)6.93647502
5keratinocyte proliferation (GO:0043616)6.87814460
6regulation of cell proliferation involved in kidney development (GO:1901722)6.79622092
7keratinocyte differentiation (GO:0030216)6.78976990
8sphingoid metabolic process (GO:0046519)6.52756097
9hemidesmosome assembly (GO:0031581)6.51917264
10molting cycle (GO:0042303)6.45147211
11hair cycle (GO:0042633)6.45147211
12bundle of His cell to Purkinje myocyte communication (GO:0086069)6.00809632
13regulation of keratinocyte proliferation (GO:0010837)5.99058063
14regulation of transforming growth factor beta1 production (GO:0032908)5.78185903
15positive regulation of interleukin-8 secretion (GO:2000484)5.76522153
16positive regulation of glomerulus development (GO:0090193)5.74971905
17epidermal cell differentiation (GO:0009913)5.48860326
18long-chain fatty acid biosynthetic process (GO:0042759)5.46302708
19interferon-gamma secretion (GO:0072643)5.37926861
20sphingosine metabolic process (GO:0006670)5.36708554
21detection of bacterium (GO:0016045)5.31237947
22gap junction assembly (GO:0016264)5.15208955
23regulation of hair follicle development (GO:0051797)5.14914713
24epidermis development (GO:0008544)5.05300757
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.02701169
26regulation of phospholipase A2 activity (GO:0032429)5.00274031
27positive regulation of epidermis development (GO:0045684)4.97327199
28regulation of ruffle assembly (GO:1900027)4.97272133
29cell adhesion mediated by integrin (GO:0033627)4.95158820
30chemical homeostasis within a tissue (GO:0048875)4.94057705
31diol metabolic process (GO:0034311)4.93243453
32positive regulation of epidermal cell differentiation (GO:0045606)4.91326037
33peptide cross-linking (GO:0018149)4.89348877
34regulation of transforming growth factor beta2 production (GO:0032909)4.89243848
35intermediate filament organization (GO:0045109)4.81387233
36glucosamine-containing compound catabolic process (GO:1901072)4.69728630
37polarized epithelial cell differentiation (GO:0030859)4.68117240
38positive regulation of hair cycle (GO:0042635)4.57728360
39positive regulation of hair follicle development (GO:0051798)4.57728360
40detection of other organism (GO:0098543)4.48536763
41fatty acid elongation (GO:0030497)4.40287330
42surfactant homeostasis (GO:0043129)4.38733526
43viral transcription (GO:0019083)4.35645881
44regulation of interleukin-8 secretion (GO:2000482)4.30923000
45epithelial cell differentiation involved in prostate gland development (GO:0060742)4.19174047
46regulation of glomerulus development (GO:0090192)4.13276442
47translational termination (GO:0006415)4.08080421
48lipoxygenase pathway (GO:0019372)4.04876183
49regulation of epidermis development (GO:0045682)4.01406639
50positive regulation of keratinocyte differentiation (GO:0045618)3.99669922
51linoleic acid metabolic process (GO:0043651)3.98333687
52positive regulation of cholesterol efflux (GO:0010875)3.97741995
53mesodermal cell differentiation (GO:0048333)3.96581689
54keratinocyte development (GO:0003334)3.90350090
55ribosomal small subunit biogenesis (GO:0042274)3.85981897
56regulation of hair cycle (GO:0042634)3.85174018
57hypotonic response (GO:0006971)3.84056550
58negative regulation of chondrocyte differentiation (GO:0032331)3.77576772
59ectoderm development (GO:0007398)3.72131601
60negative regulation of epidermis development (GO:0045683)3.69789754
61phospholipid efflux (GO:0033700)3.69520600
62membrane raft organization (GO:0031579)3.69448585
63regulation of chemokine secretion (GO:0090196)3.65049090
64eyelid development in camera-type eye (GO:0061029)3.59972569
65protein localization to endosome (GO:0036010)3.56192754
66prostanoid biosynthetic process (GO:0046457)3.54577789
67prostaglandin biosynthetic process (GO:0001516)3.54577789
68negative regulation of axon extension involved in axon guidance (GO:0048843)3.52413591
69cyclooxygenase pathway (GO:0019371)3.51764626
70positive regulation of sterol transport (GO:0032373)3.51337841
71positive regulation of cholesterol transport (GO:0032376)3.51337841
72regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.43745774
73endodermal cell differentiation (GO:0035987)3.39421301
74cell junction assembly (GO:0034329)3.36608566
75regulation of epidermal cell differentiation (GO:0045604)3.33205069
76negative regulation of keratinocyte proliferation (GO:0010839)3.24891213
77planar cell polarity pathway involved in neural tube closure (GO:0090179)3.24074326
78cardiac right ventricle morphogenesis (GO:0003215)3.23916509
79establishment of tissue polarity (GO:0007164)3.23777044
80establishment of planar polarity (GO:0001736)3.23777044
81cell junction organization (GO:0034330)3.23710111
82morphogenesis of embryonic epithelium (GO:0016331)3.19045296
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17287911
84viral life cycle (GO:0019058)3.17141481
85translational elongation (GO:0006414)3.14239111
86gland morphogenesis (GO:0022612)3.13799223
87diterpenoid biosynthetic process (GO:0016102)3.12763317
88positive regulation of mitochondrial membrane permeability (GO:0035794)3.12060097
89protein targeting to ER (GO:0045047)3.11833773
90lateral sprouting from an epithelium (GO:0060601)3.10426845
91cotranslational protein targeting to membrane (GO:0006613)3.10140679
92limb bud formation (GO:0060174)3.08930076
93prostanoid metabolic process (GO:0006692)3.08224404
94prostaglandin metabolic process (GO:0006693)3.08224404
95intermediate filament-based process (GO:0045103)3.08199866
96intermediate filament cytoskeleton organization (GO:0045104)3.08127738
97membrane budding (GO:0006900)3.07522273
98cellular protein complex disassembly (GO:0043624)3.04034926
99negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.03504772
100establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03495342
101skin development (GO:0043588)3.02959765
102cellular copper ion homeostasis (GO:0006878)3.02364756
103COPI coating of Golgi vesicle (GO:0048205)3.01899141
104Golgi transport vesicle coating (GO:0048200)3.01899141
105ventricular cardiac muscle cell action potential (GO:0086005)2.99125138
106regulation of transforming growth factor beta production (GO:0071634)2.99020831
107regulation of natural killer cell differentiation (GO:0032823)2.98864682
108regulation of cardioblast differentiation (GO:0051890)2.98652841
109ribosomal small subunit assembly (GO:0000028)2.97906352
110negative regulation of kidney development (GO:0090185)2.96244292
111regulation of metalloenzyme activity (GO:0048552)2.94057808
112cell-substrate adherens junction assembly (GO:0007045)2.93036599
113focal adhesion assembly (GO:0048041)2.93036599
114skin morphogenesis (GO:0043589)2.92344878
115negative regulation of stress fiber assembly (GO:0051497)2.92266748
116positive regulation of chemokine secretion (GO:0090197)2.92069783
117phospholipid scrambling (GO:0017121)2.90884810
118protein localization to endoplasmic reticulum (GO:0070972)2.89984365
119positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.87818816
120one-carbon compound transport (GO:0019755)2.87791938
121negative regulation of cell fate specification (GO:0009996)2.86985452
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86482374
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85622088
124negative regulation of interferon-gamma production (GO:0032689)2.85374167
125mammary gland epithelial cell proliferation (GO:0033598)2.84912174
126epithelial cell-cell adhesion (GO:0090136)2.82860745
127protein localization to microtubule (GO:0035372)2.79014239
128negative regulation of cell fate commitment (GO:0010454)2.75645427
129atrioventricular valve morphogenesis (GO:0003181)2.75486973
130cell differentiation involved in embryonic placenta development (GO:0060706)2.75480071
131activation of Rac GTPase activity (GO:0032863)2.72830006
132regulation of cholesterol efflux (GO:0010874)2.72819818
133positive regulation of transforming growth factor beta production (GO:0071636)2.71413234
134maturation of SSU-rRNA (GO:0030490)2.71234146
135terpenoid biosynthetic process (GO:0016114)2.71145776
136long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.67465028
137sympathetic nervous system development (GO:0048485)2.67142034
138negative regulation of axon guidance (GO:1902668)2.66830899
139hormone catabolic process (GO:0042447)2.64800749
140regulation of keratinocyte differentiation (GO:0045616)2.63307330
141intestinal epithelial cell development (GO:0060576)2.63131627
142hair follicle morphogenesis (GO:0031069)2.62721781
143phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61731623
144positive regulation of Cdc42 GTPase activity (GO:0043089)2.61190586
145negative regulation of stem cell proliferation (GO:2000647)2.58552758
146regulation of glomerular filtration (GO:0003093)2.57612664
147glutathione biosynthetic process (GO:0006750)2.57364267
148wound healing (GO:0042060)2.56705898
149epithelium development (GO:0060429)2.55843762
150morphogenesis of an epithelial fold (GO:0060571)2.54968346
151L-serine transport (GO:0015825)2.54412885
152hepatocyte differentiation (GO:0070365)2.53754697
153negative regulation of cartilage development (GO:0061037)2.53437284
154renal filtration (GO:0097205)2.52644458
155molting cycle process (GO:0022404)2.52633982
156hair cycle process (GO:0022405)2.52633982
157cell-cell junction assembly (GO:0007043)2.51689254
158regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.49404646
159adherens junction organization (GO:0034332)2.48538439
160adherens junction assembly (GO:0034333)2.46097637
161natural killer cell mediated cytotoxicity (GO:0042267)2.45230200
162natural killer cell mediated immunity (GO:0002228)2.45230200
163establishment of skin barrier (GO:0061436)13.6404564
164desmosome organization (GO:0002934)13.1016889
165regulation of water loss via skin (GO:0033561)12.3650042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.56278864
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.02998318
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.85126238
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.77177471
5* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55708435
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.49838561
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.06835561
8TP63_17297297_ChIP-ChIP_HaCaT_Human14.4362071
9FOXO3_23340844_ChIP-Seq_DLD1_Human1.97839000
10* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97250304
11* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97250304
12STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96792633
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95137814
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.93256073
15AR_21909140_ChIP-Seq_LNCAP_Human1.88192970
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82036624
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65337684
18* TP53_18474530_ChIP-ChIP_U2OS_Human1.63953802
19ZNF263_19887448_ChIP-Seq_K562_Human1.63867754
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.60442383
21* SOX2_20726797_ChIP-Seq_SW620_Human1.59265389
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52461882
23* TP63_23658742_ChIP-Seq_EP156T_Human1.51980981
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44361147
25ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.42442337
26* CJUN_26792858_Chip-Seq_BT549_Human1.35232996
27AR_21572438_ChIP-Seq_LNCaP_Human1.34512579
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33774406
29BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23589541
30* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22943060
31AHR_22903824_ChIP-Seq_MCF-7_Human1.22317133
32KLF5_25053715_ChIP-Seq_YYC3_Human1.21024406
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19006360
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18181445
35GATA4_25053715_ChIP-Seq_YYC3_Human1.17358799
36BCAT_22108803_ChIP-Seq_LS180_Human1.17336854
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17192431
38EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16644298
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15011616
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14638856
41RXR_22108803_ChIP-Seq_LS180_Human1.13513501
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.12291163
43TP53_16413492_ChIP-PET_HCT116_Human1.12281232
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12236423
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10320409
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08895298
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07260005
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06783101
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04395450
50* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04161071
51TP63_22573176_ChIP-Seq_HFKS_Human1.04077442
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.03079851
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.00407955
54HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97332026
55GATA6_21074721_ChIP-Seq_CACO-2_Human0.96946455
56CDX2_20551321_ChIP-Seq_CACO-2_Human0.96313058
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96044275
58FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96000450
59GATA1_22025678_ChIP-Seq_K562_Human0.95501651
60ARNT_22903824_ChIP-Seq_MCF-7_Human0.94108627
61BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93744575
62ELK3_25401928_ChIP-Seq_HUVEC_Human0.92800875
63EZH2_27304074_Chip-Seq_ESCs_Mouse0.92247437
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92031931
65SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91087230
66TCF4_22108803_ChIP-Seq_LS180_Human0.90740548
67UBF1/2_26484160_Chip-Seq_HMECs_Human0.90359827
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90279577
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89972625
70SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89260428
71JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87443053
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87440816
73RNF2_27304074_Chip-Seq_ESCs_Mouse0.86329618
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85498144
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85498144
76KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84714809
77RBPJ_21746931_ChIP-Seq_IB4_Human0.84410880
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84019655
79GATA6_25053715_ChIP-Seq_YYC3_Human0.83779239
80ELK1_22589737_ChIP-Seq_MCF10A_Human0.83050849
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82575735
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80981544
83RACK7_27058665_Chip-Seq_MCF-7_Human0.80687610
84NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80650698
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80463869
86BRD4_25478319_ChIP-Seq_HGPS_Human0.80380734
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80116145
88ELF5_23300383_ChIP-Seq_T47D_Human0.79158278
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79071704
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79036538
91* CEBPB_22108803_ChIP-Seq_LS180_Human0.78805745
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78697005
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.77817611
94* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77316327
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76888793
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76869166
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76357732
98TP53_22127205_ChIP-Seq_IMR90_Human0.76096863
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.76043703
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.75069506
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74020563
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73443799
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71824487
104BP1_19119308_ChIP-ChIP_Hs578T_Human0.71792758
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71466231
106CHD1_26751641_Chip-Seq_LNCaP_Human0.71465660
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.70644218
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70555220
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70314725
110EZH2_27294783_Chip-Seq_ESCs_Mouse0.69577886
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69122529
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.66776119
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.66269813
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66002985
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.65934499
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.65934499
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65767523
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65694497
119HNFA_21074721_ChIP-Seq_CACO-2_Human0.65392981
120ATF3_27146783_Chip-Seq_COLON_Human0.64915426
121CLOCK_20551151_ChIP-Seq_293T_Human0.64912124
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64648152
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63817172
124PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.63688968
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.63415127
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.63415127
127NANOG_18692474_ChIP-Seq_MEFs_Mouse0.63375784
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.63047917
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62874657
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62516538
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.62454013
132PHF8_20622853_ChIP-Seq_HELA_Human0.62204838
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.61931544
134CTCF_27219007_Chip-Seq_Bcells_Human0.61859531
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.61834343
136NELFA_20434984_ChIP-Seq_ESCs_Mouse0.61431588
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.59367110
138MYC_18555785_ChIP-Seq_MESCs_Mouse0.56734632
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.54739026
140ZFX_18555785_ChIP-Seq_MESCs_Mouse0.53497171
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.51412295
142EOMES_21245162_ChIP-Seq_HESCs_Human0.50655909
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.50092220
144ESR1_15608294_ChIP-ChIP_MCF-7_Human0.49952231
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49677572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.60041766
2MP0003941_abnormal_skin_development6.02319716
3MP0010234_abnormal_vibrissa_follicle5.62346307
4MP0004381_abnormal_hair_follicle4.54910051
5MP0005501_abnormal_skin_physiology4.47611300
6MP0002254_reproductive_system_inflammat4.31374500
7MP0005275_abnormal_skin_tensile4.10134157
8MP0000383_abnormal_hair_follicle3.46055723
9MP0010678_abnormal_skin_adnexa3.42330396
10MP0002060_abnormal_skin_morphology3.24035710
11MP0005451_abnormal_body_composition3.23580527
12MP0001216_abnormal_epidermal_layer3.18638469
13MP0002098_abnormal_vibrissa_morphology3.07427947
14MP0000647_abnormal_sebaceous_gland2.86416800
15MP0010771_integument_phenotype2.85152523
16MP0003453_abnormal_keratinocyte_physiol2.84362016
17MP0000579_abnormal_nail_morphology2.82609218
18MP0000566_synostosis2.63567323
19MP0004947_skin_inflammation2.54738326
20MP0001346_abnormal_lacrimal_gland2.43100349
21MP0000377_abnormal_hair_follicle2.40569263
22MP0004272_abnormal_basement_membrane2.31331617
23MP0002009_preneoplasia2.18444344
24MP0000467_abnormal_esophagus_morphology2.16289540
25MP0001849_ear_inflammation2.11722877
26MP0000427_abnormal_hair_cycle2.10025983
27MP0003191_abnormal_cellular_cholesterol1.96924516
28MP0009379_abnormal_foot_pigmentation1.94461269
29MP0000762_abnormal_tongue_morphology1.87774106
30MP0004782_abnormal_surfactant_physiolog1.77213896
31MP0009931_abnormal_skin_appearance1.63743194
32MP0003136_yellow_coat_color1.54311128
33MP0001191_abnormal_skin_condition1.53459966
34MP0003950_abnormal_plasma_membrane1.52397552
35MP0003566_abnormal_cell_adhesion1.37970931
36MP0001243_abnormal_dermal_layer1.21832212
37MP0008260_abnormal_autophagy1.21105401
38MP0000367_abnormal_coat/_hair1.20883195
39MP0004185_abnormal_adipocyte_glucose1.15092293
40MP0002877_abnormal_melanocyte_morpholog1.14273141
41MP0008789_abnormal_olfactory_epithelium1.13869152
42MP0005257_abnormal_intraocular_pressure1.11831702
43MP0010030_abnormal_orbit_morphology1.09895373
44MP0005499_abnormal_olfactory_system1.07498428
45MP0005394_taste/olfaction_phenotype1.07498428
46MP0000858_altered_metastatic_potential1.02692706
47MP0003806_abnormal_nucleotide_metabolis1.01037257
48MP0000465_gastrointestinal_hemorrhage0.96862802
49MP0009384_cardiac_valve_regurgitation0.96411020
50MP0005360_urolithiasis0.92353994
51MP0003705_abnormal_hypodermis_morpholog0.91516473
52MP0002277_abnormal_respiratory_mucosa0.91446618
53MP0001340_abnormal_eyelid_morphology0.90693262
54MP0001851_eye_inflammation0.85607450
55MP0001984_abnormal_olfaction0.80252372
56MP0002090_abnormal_vision0.75185483
57MP0004957_abnormal_blastocyst_morpholog0.74578832
58MP0005197_abnormal_uvea_morphology0.74204701
59MP0005248_abnormal_Harderian_gland0.72465085
60MP0010352_gastrointestinal_tract_polyps0.69282447
61MP0009053_abnormal_anal_canal0.67148142
62MP0004264_abnormal_extraembryonic_tissu0.66429255
63MP0005193_abnormal_anterior_eye0.65627671
64MP0005023_abnormal_wound_healing0.64949863
65MP0002177_abnormal_outer_ear0.63783222
66MP0003091_abnormal_cell_migration0.63180424
67MP0005075_abnormal_melanosome_morpholog0.62661874
68MP0002234_abnormal_pharynx_morphology0.61944652
69MP0000462_abnormal_digestive_system0.60777667
70MP0000372_irregular_coat_pigmentation0.60017237
71MP0005164_abnormal_response_to0.59404990
72MP0003195_calcinosis0.59261889
73MP0000538_abnormal_urinary_bladder0.58832281
74MP0002697_abnormal_eye_size0.58325078
75MP0002089_abnormal_postnatal_growth/wei0.57491871
76MP0003786_premature_aging0.57087687
77MP0002233_abnormal_nose_morphology0.56029852
78MP0008932_abnormal_embryonic_tissue0.55906372
79MP0002896_abnormal_bone_mineralization0.54403472
80MP0001784_abnormal_fluid_regulation0.53710927
81MP0005409_darkened_coat_color0.53667423
82MP0002095_abnormal_skin_pigmentation0.53593568
83MP0002166_altered_tumor_susceptibility0.52651554
84MP0005076_abnormal_cell_differentiation0.52127418
85MP0000537_abnormal_urethra_morphology0.52077105
86MP0000627_abnormal_mammary_gland0.51081589
87MP0000470_abnormal_stomach_morphology0.49844727
88MP0000003_abnormal_adipose_tissue0.49743007
89MP0000516_abnormal_urinary_system0.49128237
90MP0005367_renal/urinary_system_phenotyp0.49128237
91MP0008004_abnormal_stomach_pH0.49101404
92MP0003828_pulmonary_edema0.48758014
93MP0002006_tumorigenesis0.48504659
94MP0003755_abnormal_palate_morphology0.46732454
95MP0002249_abnormal_larynx_morphology0.46133447
96MP0001881_abnormal_mammary_gland0.45736715
97MP0003045_fibrosis0.45570732
98MP0010368_abnormal_lymphatic_system0.45254771
99MP0005621_abnormal_cell_physiology0.45199017
100MP0004197_abnormal_fetal_growth/weight/0.44466671
101MP0003011_delayed_dark_adaptation0.44455388
102MP0000750_abnormal_muscle_regeneration0.44198970
103MP0000733_abnormal_muscle_development0.43561369
104MP0002086_abnormal_extraembryonic_tissu0.42790163
105MP0000613_abnormal_salivary_gland0.42701322
106MP0003938_abnormal_ear_development0.42466034
107MP0001853_heart_inflammation0.41950018
108MP0008961_abnormal_basal_metabolism0.41542700
109MP0009250_abnormal_appendicular_skeleto0.41289816
110MP0001542_abnormal_bone_strength0.41225980
111MP0002132_abnormal_respiratory_system0.40791512
112MP0005165_increased_susceptibility_to0.40696384
113MP0005647_abnormal_sex_gland0.40591601
114MP0001177_atelectasis0.40579801
115MP0000350_abnormal_cell_proliferation0.39690566
116MP0001661_extended_life_span0.38383551
117MP0008875_abnormal_xenobiotic_pharmacok0.38316855
118MP0003693_abnormal_embryo_hatching0.37602729
119MP0006054_spinal_hemorrhage0.37529629
120MP0005623_abnormal_meninges_morphology0.37520533
121MP0009780_abnormal_chondrocyte_physiolo0.36828096
122MP0005083_abnormal_biliary_tract0.36787862
123MP0003935_abnormal_craniofacial_develop0.36737128
124MP0005508_abnormal_skeleton_morphology0.34699254
125MP0000432_abnormal_head_morphology0.31481784
126MP0004019_abnormal_vitamin_homeostasis0.30079028
127MP0003315_abnormal_perineum_morphology0.29380686
128MP0010386_abnormal_urinary_bladder0.27718279
129MP0002282_abnormal_trachea_morphology0.27365288
130MP0002133_abnormal_respiratory_system0.26893445
131MP0005388_respiratory_system_phenotype0.26893445
132MP0002111_abnormal_tail_morphology0.26010611
133MP0005187_abnormal_penis_morphology0.25916039
134MP0000678_abnormal_parathyroid_gland0.25787553
135MP0003385_abnormal_body_wall0.23717687
136MP0001299_abnormal_eye_distance/0.23620119
137MP0002295_abnormal_pulmonary_circulatio0.23565173

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)7.55456887
2Lip pit (HP:0100267)7.16922528
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.89188605
4Hypotrichosis (HP:0001006)6.81811788
5Woolly hair (HP:0002224)6.14885805
6Abnormality of nail color (HP:0100643)5.84086673
7Right ventricular cardiomyopathy (HP:0011663)5.81102449
8Parakeratosis (HP:0001036)5.59907902
9Plantar hyperkeratosis (HP:0007556)5.43883749
10Increased IgE level (HP:0003212)5.34770915
11Fragile nails (HP:0001808)5.25452578
12Palmoplantar hyperkeratosis (HP:0000972)4.94282362
13Palmar hyperkeratosis (HP:0010765)4.65445530
14Onycholysis (HP:0001806)4.65305717
15Ectropion (HP:0000656)4.35360900
16Erythema (HP:0010783)4.25816726
17Gangrene (HP:0100758)4.21506361
18Erythroderma (HP:0001019)4.12037949
19Milia (HP:0001056)4.09019154
20Hypohidrosis (HP:0000966)4.01702103
21Pili torti (HP:0003777)3.98921438
22Corneal erosion (HP:0200020)3.97434933
23Selective tooth agenesis (HP:0001592)3.94816824
24Oral leukoplakia (HP:0002745)3.76183633
25Nail dystrophy (HP:0008404)3.68203901
26Sparse scalp hair (HP:0002209)3.65697158
27Pruritus (HP:0000989)3.64415566
28Natal tooth (HP:0000695)3.54981748
29Sparse eyelashes (HP:0000653)3.37863610
30Fragile skin (HP:0001030)3.36823568
31Abnormal blistering of the skin (HP:0008066)3.33296573
32Popliteal pterygium (HP:0009756)3.30077998
33Abnormality of the axillary hair (HP:0100134)3.26124952
34Abnormality of secondary sexual hair (HP:0009888)3.26124952
35Curly hair (HP:0002212)3.22495975
36Amniotic constriction ring (HP:0009775)3.21900934
37Abnormality of placental membranes (HP:0011409)3.21900934
38Thick nail (HP:0001805)3.16553335
39Absent eyelashes (HP:0000561)3.16323384
40Ankyloglossia (HP:0010296)3.15008351
41Congenital, generalized hypertrichosis (HP:0004540)3.10396394
42Palmoplantar keratoderma (HP:0000982)3.06096911
43Advanced eruption of teeth (HP:0006288)2.99728591
44Stenosis of the external auditory canal (HP:0000402)2.99026468
45Hyporeflexia of lower limbs (HP:0002600)2.94076923
46Abnormality of the salivary glands (HP:0010286)2.88629690
47Anhidrosis (HP:0000970)2.84902624
48Eczematoid dermatitis (HP:0000976)2.82302446
49Concave nail (HP:0001598)2.80317276
50Aplasia cutis congenita (HP:0001057)2.79016031
51Distal lower limb muscle weakness (HP:0009053)2.78752515
52Brittle hair (HP:0002299)2.76897107
53Acanthosis nigricans (HP:0000956)2.76345414
54Hypoplastic labia majora (HP:0000059)2.72210862
55Anonychia (HP:0001798)2.63756545
56Ventricular tachycardia (HP:0004756)2.63120667
57Abnormality of cells of the erythroid lineage (HP:0012130)2.57377103
58Oligodontia (HP:0000677)2.57175341
59Alopecia of scalp (HP:0002293)2.51225759
60Abnormality of oral frenula (HP:0000190)2.49756381
61Conical tooth (HP:0000698)2.48971658
62Dehydration (HP:0001944)2.47849305
63Dry skin (HP:0000958)2.45579787
64Carious teeth (HP:0000670)2.45254854
65Blepharitis (HP:0000498)2.44918019
66Abnormality of the labia majora (HP:0012881)2.44241545
67Abnormal hemoglobin (HP:0011902)2.44131582
68Nasolacrimal duct obstruction (HP:0000579)2.42846235
69Ridged nail (HP:0001807)2.40996734
70Lack of skin elasticity (HP:0100679)2.40356365
71Aplasia involving bones of the upper limbs (HP:0009823)2.37758209
72Aplasia of the phalanges of the hand (HP:0009802)2.37758209
73Aplasia involving bones of the extremities (HP:0009825)2.37758209
74Atrophic scars (HP:0001075)2.28709562
75Malignant hyperthermia (HP:0002047)2.26595212
76Abnormal hair laboratory examination (HP:0003328)2.20522409
77Type I diabetes mellitus (HP:0100651)2.16362715
78Absent eyebrow (HP:0002223)2.15553205
79Abnormal number of erythroid precursors (HP:0012131)2.15262112
80Abnormality of the gastric mucosa (HP:0004295)2.14849986
81Bifid scrotum (HP:0000048)2.14314658
82Septate vagina (HP:0001153)2.14215596
83Abnormality of the lacrimal duct (HP:0011481)2.09185202
84Humeroradial synostosis (HP:0003041)2.08017286
85Synostosis involving the elbow (HP:0003938)2.08017286
86Pterygium (HP:0001059)2.07885769
87Areflexia of lower limbs (HP:0002522)2.05608519
88Trismus (HP:0000211)2.04844462
89Sepsis (HP:0100806)2.04791899
90Reticulocytopenia (HP:0001896)2.02760861
91Skin pits (HP:0100276)2.01399762
92Abnormality of the fingernails (HP:0001231)2.01183917
93Dry hair (HP:0011359)1.99027967
94Cheilitis (HP:0100825)1.96164522
95Stomach cancer (HP:0012126)1.96101741
96Abnormality of permanent molar morphology (HP:0011071)1.95649359
97Abnormality of the dental root (HP:0006486)1.95649359
98Taurodontia (HP:0000679)1.95649359
99Macrocytic anemia (HP:0001972)1.91297044
100Hypoplasia of dental enamel (HP:0006297)1.91206158
101Breast hypoplasia (HP:0003187)1.91203760
102Urethral obstruction (HP:0000796)1.90858126
103Absent hair (HP:0002298)1.88546604
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86648583
105Cupped ear (HP:0000378)1.84587556
106Hypodontia (HP:0000668)1.84132203
107Squamous cell carcinoma (HP:0002860)1.83479749
108Hypoplastic female external genitalia (HP:0012815)1.83371353
109Fatigable weakness (HP:0003473)1.82609429
110Abnormality of the neuromuscular junction (HP:0003398)1.82609429
111Short nail (HP:0001799)1.82431168
112Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81335212
113Split foot (HP:0001839)1.80560815
114Abnormality of molar (HP:0011077)1.77073520
115Abnormality of molar morphology (HP:0011070)1.77073520
116Hypoplasia of the uterus (HP:0000013)1.76419919
117Multifactorial inheritance (HP:0001426)1.74505966
118Esophageal atresia (HP:0002032)1.74126124
119Labial hypoplasia (HP:0000066)1.74031309
120Abnormality of the nasolacrimal system (HP:0000614)1.72811102
121Abnormality of the nasal septum (HP:0000419)1.72145904
122Poikiloderma (HP:0001029)1.71617036
123Follicular hyperkeratosis (HP:0007502)1.71332808
124Amelogenesis imperfecta (HP:0000705)1.71285039
125Hypergammaglobulinemia (HP:0010702)1.70922470
126Xerostomia (HP:0000217)1.69676286
127Pustule (HP:0200039)1.69432697
128Abnormality of the dental pulp (HP:0006479)1.67926676
129Aplasia/hypoplasia of the uterus (HP:0008684)1.66353908
130Autoamputation (HP:0001218)1.66184674
131Corneal dystrophy (HP:0001131)1.64836074
132Skin ulcer (HP:0200042)1.64691358
133Hyperhidrosis (HP:0000975)1.64022599
134Hoarse voice (HP:0001609)1.63536351
135Epidermoid cyst (HP:0200040)1.62197528
136Upper limb muscle weakness (HP:0003484)1.61652891
137Periodontitis (HP:0000704)1.58480490
138Death in infancy (HP:0001522)1.55540365
139Abnormality of the distal phalanges of the toes (HP:0010182)1.55410960
140Deviation of the thumb (HP:0009603)1.54387645
141Vascular calcification (HP:0004934)1.54271227
142Laryngomalacia (HP:0001601)1.53807369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.02070003
2MAPKAPK33.97393342
3MST1R3.96033169
4MST43.90930809
5MAP3K23.42956578
6ARAF3.16033419
7FER2.77609585
8MAP3K92.66167579
9RPS6KB22.44039173
10TRPM72.43840383
11ERBB32.40631931
12PIM22.21944119
13EPHB22.17838584
14LATS12.13517386
15MAP3K142.10525761
16NTRK12.09188474
17PAK41.89091549
18FRK1.86480468
19SIK11.76203358
20EPHA31.72649290
21FLT31.66102491
22EPHA21.62916063
23MAP3K61.59113570
24FGFR21.57227529
25FGFR11.51055222
26BMPR21.49027159
27MAPK151.46221545
28LMTK21.42587467
29NEK11.37926622
30CASK1.37316270
31TESK11.36779746
32PDGFRA1.34149882
33EIF2AK11.30764276
34ERN11.29748534
35BCR1.28692726
36MAPKAPK51.28512576
37IKBKE1.27591925
38EIF2AK31.11374908
39PTK61.10613493
40ITK1.10176539
41LRRK21.09722089
42MAP2K61.06862914
43MAPKAPK21.06271498
44BMPR1B1.05361210
45TNK21.05056490
46STK101.04302640
47PBK1.03707605
48GRK71.02761864
49ERBB41.01760690
50IKBKB1.01108483
51DYRK1B1.00744120
52SRPK10.99761388
53ZAK0.99533949
54STK240.98917812
55GRK10.97715661
56SIK30.94456706
57RPS6KA40.94326356
58PIK3CG0.93486324
59MAP2K20.92537700
60MET0.92050666
61GRK50.91283846
62TGFBR20.91275906
63TBK10.90236024
64IRAK30.90021008
65RIPK10.89075480
66BRAF0.86962705
67KSR20.85868863
68STK30.83596220
69FGFR40.83261647
70MAP3K10.81795271
71CHUK0.78450403
72EIF2AK20.77108461
73CDK60.76813664
74RAF10.76288495
75MYLK0.75117406
76TYK20.74558330
77BMX0.74177493
78EPHB10.72429925
79MOS0.72424329
80FGFR30.70713356
81SMG10.70188154
82PAK30.69227588
83PTK20.69182795
84NME10.69101475
85SCYL20.68666716
86MAP3K110.68039514
87KSR10.64161544
88ABL20.63885967
89LATS20.63580654
90ILK0.61657774
91MAP2K40.60478621
92CDK120.60132759
93CDK30.59172309
94MAP2K10.57215447
95PDGFRB0.56223383
96STK380.55813038
97AURKA0.54371459
98INSRR0.54268171
99MAP2K30.54097478
100PRKCE0.53251217
101ERBB20.52928828
102NEK60.52507896
103TAOK10.52218821
104BUB10.51880445
105NME20.51793122
106ROCK20.49514712
107NUAK10.49264188
108RPS6KA10.48666607
109MAP3K50.47517568
110TRIM280.45993657
111TTN0.45682980
112CDK80.44572019
113TGFBR10.42484945
114NLK0.41875587
115MAP3K120.41574063
116ADRBK10.41089753
117MAP3K130.40751813
118MAP3K80.40476097
119JAK20.39219637
120CSF1R0.38739047
121TEC0.37794976
122MAP3K70.36757268
123HIPK20.36641238
124STK110.35958138
125BLK0.35711101
126RIPK40.35549286
127CSNK1D0.35317923
128MAPK70.35190182
129PRKCI0.34000736
130STK38L0.33788356
131RPS6KC10.33788165
132RPS6KL10.33788165
133PRKD10.33760469
134RPS6KA60.33240683
135TYRO30.32491364
136TRIB30.31974399
137RPS6KA20.31957046
138TTK0.31527674
139PDK20.30779010
140MTOR0.28983012
141AURKB0.27920041
142CDK90.27847753
143CAMK2G0.25356134
144RET0.25260690
145DMPK0.20287032
146IGF1R0.19558874
147BRSK20.19533323
148TSSK60.19342602
149ROCK10.19126720
150BRD40.17910775
151PAK20.17334198
152PRKCD0.16787020
153RPS6KB10.16207211

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.72228011
2Sphingolipid metabolism_Homo sapiens_hsa006003.67793878
3Caffeine metabolism_Homo sapiens_hsa002323.32545457
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.01444634
5Arachidonic acid metabolism_Homo sapiens_hsa005902.76899038
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.71876763
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.68241908
8Linoleic acid metabolism_Homo sapiens_hsa005912.65717618
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57630470
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55224990
11Chemical carcinogenesis_Homo sapiens_hsa052042.53844695
12Focal adhesion_Homo sapiens_hsa045102.41894640
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27863324
14Fatty acid elongation_Homo sapiens_hsa000622.18041079
15Retinol metabolism_Homo sapiens_hsa008302.17758408
16Histidine metabolism_Homo sapiens_hsa003402.09825971
17Phenylalanine metabolism_Homo sapiens_hsa003601.97635157
18Proteasome_Homo sapiens_hsa030501.95222491
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92675118
20Ether lipid metabolism_Homo sapiens_hsa005651.83154435
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65532358
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.61978617
23ABC transporters_Homo sapiens_hsa020101.58875055
24Basal cell carcinoma_Homo sapiens_hsa052171.57057980
25Glutathione metabolism_Homo sapiens_hsa004801.46407097
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40404726
27Pancreatic cancer_Homo sapiens_hsa052121.40039029
28Shigellosis_Homo sapiens_hsa051311.34838532
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.33634061
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30792775
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28165701
32Adherens junction_Homo sapiens_hsa045201.26146387
33Tight junction_Homo sapiens_hsa045301.26015027
34Chronic myeloid leukemia_Homo sapiens_hsa052201.25990380
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25277389
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24127498
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21066752
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20634897
39Renal cell carcinoma_Homo sapiens_hsa052111.19128324
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.18357714
41N-Glycan biosynthesis_Homo sapiens_hsa005101.16870570
42Galactose metabolism_Homo sapiens_hsa000521.14577958
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11870453
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11072283
45Hippo signaling pathway_Homo sapiens_hsa043901.07245567
46Axon guidance_Homo sapiens_hsa043601.05941135
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04759838
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02327976
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01886200
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01393530
51p53 signaling pathway_Homo sapiens_hsa041151.01349934
52Glioma_Homo sapiens_hsa052141.00652689
53Pertussis_Homo sapiens_hsa051330.99853615
54Tyrosine metabolism_Homo sapiens_hsa003500.97740304
55Salmonella infection_Homo sapiens_hsa051320.96761914
56Bladder cancer_Homo sapiens_hsa052190.96610803
57Melanogenesis_Homo sapiens_hsa049160.96341191
58Mineral absorption_Homo sapiens_hsa049780.96318301
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95029517
60Serotonergic synapse_Homo sapiens_hsa047260.92264560
61Hedgehog signaling pathway_Homo sapiens_hsa043400.90581608
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90055829
63Endocytosis_Homo sapiens_hsa041440.87271796
64Dilated cardiomyopathy_Homo sapiens_hsa054140.87041598
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86436227
66Toxoplasmosis_Homo sapiens_hsa051450.85824029
67ECM-receptor interaction_Homo sapiens_hsa045120.85664535
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83985535
69Nucleotide excision repair_Homo sapiens_hsa034200.82318224
70Renin secretion_Homo sapiens_hsa049240.81812084
71VEGF signaling pathway_Homo sapiens_hsa043700.81786895
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81129533
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81075658
74Hepatitis C_Homo sapiens_hsa051600.80630996
75Circadian rhythm_Homo sapiens_hsa047100.78645970
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76626332
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76405384
78Inositol phosphate metabolism_Homo sapiens_hsa005620.75213107
79Proteoglycans in cancer_Homo sapiens_hsa052050.75105819
80Cell cycle_Homo sapiens_hsa041100.75066529
81Thyroid cancer_Homo sapiens_hsa052160.73125052
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72333013
83TNF signaling pathway_Homo sapiens_hsa046680.71890840
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.71706282
85Sulfur metabolism_Homo sapiens_hsa009200.71647658
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70757354
87Prion diseases_Homo sapiens_hsa050200.69809345
88Endometrial cancer_Homo sapiens_hsa052130.69562252
89Protein export_Homo sapiens_hsa030600.69299541
90Phototransduction_Homo sapiens_hsa047440.66601430
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66164014
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65997105
93Ras signaling pathway_Homo sapiens_hsa040140.64882100
94Notch signaling pathway_Homo sapiens_hsa043300.63761265
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62371782
96Amoebiasis_Homo sapiens_hsa051460.62302011
97MicroRNAs in cancer_Homo sapiens_hsa052060.61707870
98ErbB signaling pathway_Homo sapiens_hsa040120.60741156
99Insulin signaling pathway_Homo sapiens_hsa049100.60482098
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59321053
101Pentose phosphate pathway_Homo sapiens_hsa000300.57984965
102Fructose and mannose metabolism_Homo sapiens_hsa000510.56414602
103beta-Alanine metabolism_Homo sapiens_hsa004100.55263991
104Pancreatic secretion_Homo sapiens_hsa049720.54178718
105GnRH signaling pathway_Homo sapiens_hsa049120.53939724
106Acute myeloid leukemia_Homo sapiens_hsa052210.53333130
107Vibrio cholerae infection_Homo sapiens_hsa051100.52828920
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51580843
109Dorso-ventral axis formation_Homo sapiens_hsa043200.51264636
110Non-small cell lung cancer_Homo sapiens_hsa052230.50143879
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48197796
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.47202113
113Wnt signaling pathway_Homo sapiens_hsa043100.46600429
114Pyrimidine metabolism_Homo sapiens_hsa002400.46533757
115Fat digestion and absorption_Homo sapiens_hsa049750.46322339
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45658879
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45623339
118Vitamin digestion and absorption_Homo sapiens_hsa049770.45602413
119Rheumatoid arthritis_Homo sapiens_hsa053230.44963603
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.44119677
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43197539
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41930640
123TGF-beta signaling pathway_Homo sapiens_hsa043500.40556383
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40382540
125Small cell lung cancer_Homo sapiens_hsa052220.39927128
126Melanoma_Homo sapiens_hsa052180.37858583
127Insulin resistance_Homo sapiens_hsa049310.37783485
128Steroid biosynthesis_Homo sapiens_hsa001000.37617517
129Prolactin signaling pathway_Homo sapiens_hsa049170.37478453
130Prostate cancer_Homo sapiens_hsa052150.37217520
131Rap1 signaling pathway_Homo sapiens_hsa040150.36347604
132Gastric acid secretion_Homo sapiens_hsa049710.35808811
133Protein digestion and absorption_Homo sapiens_hsa049740.35175075
134Pathways in cancer_Homo sapiens_hsa052000.34509033
135Legionellosis_Homo sapiens_hsa051340.32725835
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32264677
137Collecting duct acid secretion_Homo sapiens_hsa049660.30604214
138Osteoclast differentiation_Homo sapiens_hsa043800.30472569
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.29775080
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29574401
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29249050
142Influenza A_Homo sapiens_hsa051640.29123907
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28970621
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.28636808
145Long-term depression_Homo sapiens_hsa047300.28468965
146Apoptosis_Homo sapiens_hsa042100.28433380
147Fatty acid biosynthesis_Homo sapiens_hsa000610.28407992
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.28159494
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27710712
150Platelet activation_Homo sapiens_hsa046110.27600172
151Lysosome_Homo sapiens_hsa041420.24160572
152RNA transport_Homo sapiens_hsa030130.20877217
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19410385
154Starch and sucrose metabolism_Homo sapiens_hsa005000.18092507

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