GPR88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic transmission, dopaminergic (GO:0001963)6.45475997
2regulation of synapse structural plasticity (GO:0051823)6.41087547
3prepulse inhibition (GO:0060134)6.27614348
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.90268096
5adenosine receptor signaling pathway (GO:0001973)5.70798714
6locomotory exploration behavior (GO:0035641)5.59858436
7striatum development (GO:0021756)5.44346227
8synaptic vesicle maturation (GO:0016188)5.43768943
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.33224197
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.26196705
11complement activation, alternative pathway (GO:0006957)5.16871943
12regulation of long-term neuronal synaptic plasticity (GO:0048169)5.15579072
13regulation of protein activation cascade (GO:2000257)5.12236229
14auditory behavior (GO:0031223)5.03432869
15blood coagulation, intrinsic pathway (GO:0007597)5.02761701
16response to amphetamine (GO:0001975)4.95365531
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93981951
18vocalization behavior (GO:0071625)4.89757839
19glyoxylate metabolic process (GO:0046487)4.86927442
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.86809127
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81011752
22epoxygenase P450 pathway (GO:0019373)4.80790282
23regulation of fibrinolysis (GO:0051917)4.80511084
24regulation of glutamate receptor signaling pathway (GO:1900449)4.77477884
25drug catabolic process (GO:0042737)4.76418383
26positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.74894587
27regulation of complement activation (GO:0030449)4.74855674
28regulation of neuronal synaptic plasticity (GO:0048168)4.71925460
29dopamine receptor signaling pathway (GO:0007212)4.71848770
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.70821167
31neurotransmitter-gated ion channel clustering (GO:0072578)4.70018102
32positive regulation of synaptic transmission, GABAergic (GO:0032230)4.69463842
33negative regulation of cytosolic calcium ion concentration (GO:0051481)4.67875772
34behavioral response to cocaine (GO:0048148)4.59307957
35regulation of dendritic spine morphogenesis (GO:0061001)4.57311375
36L-phenylalanine catabolic process (GO:0006559)4.49464941
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.49464941
38exogenous drug catabolic process (GO:0042738)4.49236123
39cAMP catabolic process (GO:0006198)4.49215987
40positive regulation of neurotransmitter transport (GO:0051590)4.44421697
41negative regulation of fibrinolysis (GO:0051918)4.44175538
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.44015381
43urea metabolic process (GO:0019627)4.41440073
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.38435418
45substrate-independent telencephalic tangential migration (GO:0021826)4.38435418
46regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.32922244
47regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.32922244
48omega-hydroxylase P450 pathway (GO:0097267)4.32918552
49response to auditory stimulus (GO:0010996)4.30708527
50regulation of female receptivity (GO:0045924)4.26056332
51dendritic spine morphogenesis (GO:0060997)4.22742384
52synaptic vesicle exocytosis (GO:0016079)4.20996630
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.17826349
54fibrinolysis (GO:0042730)4.16511463
55synaptic vesicle docking involved in exocytosis (GO:0016081)4.15087048
56neuron-neuron synaptic transmission (GO:0007270)4.11219993
57nitrogen cycle metabolic process (GO:0071941)4.10208960
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.07650413
59ionotropic glutamate receptor signaling pathway (GO:0035235)4.05824764
60regulation of synaptic vesicle exocytosis (GO:2000300)4.04897778
61regulation of glutamate secretion (GO:0014048)4.03652174
62protein localization to synapse (GO:0035418)4.00528045
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.98762513
64L-phenylalanine metabolic process (GO:0006558)3.97212189
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97212189
66neurotransmitter secretion (GO:0007269)3.96565162
67long-term memory (GO:0007616)3.96360906
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.96258228
69cyclic nucleotide catabolic process (GO:0009214)3.94716867
70peristalsis (GO:0030432)3.93962245
71* neuromuscular process controlling balance (GO:0050885)3.92717607
72urea cycle (GO:0000050)3.92707402
73exploration behavior (GO:0035640)3.90656129
74positive regulation of neurotransmitter secretion (GO:0001956)3.90228494
75positive regulation of membrane potential (GO:0045838)3.89833229
76regulation of neurotransmitter uptake (GO:0051580)3.89264563
77transmission of nerve impulse (GO:0019226)3.84249854
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84085932
79neuronal action potential propagation (GO:0019227)3.81817091
80neuronal ion channel clustering (GO:0045161)3.81625977
81phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.81491836
82bile acid biosynthetic process (GO:0006699)3.81328587
83layer formation in cerebral cortex (GO:0021819)3.79068894
84cellular glucuronidation (GO:0052695)3.76141983
85synaptic transmission, glutamatergic (GO:0035249)3.75735101
86female mating behavior (GO:0060180)3.73086443
87visual learning (GO:0008542)3.72268332
88negative regulation of cholesterol transport (GO:0032375)3.71362939
89negative regulation of sterol transport (GO:0032372)3.71362939
90cAMP metabolic process (GO:0046058)3.69867037
91protein carboxylation (GO:0018214)3.66127120
92peptidyl-glutamic acid carboxylation (GO:0017187)3.66127120
93regulation of triglyceride catabolic process (GO:0010896)3.65289319
94regulation of postsynaptic membrane potential (GO:0060078)3.65155366
95regulation of synaptic plasticity (GO:0048167)3.65144966
96mechanosensory behavior (GO:0007638)3.65023754
97gamma-aminobutyric acid transport (GO:0015812)3.63771516
98behavioral fear response (GO:0001662)3.63539036
99behavioral defense response (GO:0002209)3.63539036
100activation of protein kinase A activity (GO:0034199)3.63418483
101drug metabolic process (GO:0017144)3.61059856
102negative regulation of dendrite development (GO:2000171)3.60457692
103regulation of synaptic vesicle transport (GO:1902803)3.59705313
104regulation of protein kinase A signaling (GO:0010738)3.57233627
105regulation of voltage-gated calcium channel activity (GO:1901385)3.50000578
106bile acid metabolic process (GO:0008206)3.49643944
107visual behavior (GO:0007632)3.48865092
108response to histamine (GO:0034776)3.48356980
109regulation of dendritic spine development (GO:0060998)3.47967822
110regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47516586
111membrane hyperpolarization (GO:0060081)3.47160226
112uronic acid metabolic process (GO:0006063)3.47097238
113glucuronate metabolic process (GO:0019585)3.47097238
114response to amine (GO:0014075)3.44400527
115cerebellar granule cell differentiation (GO:0021707)3.44039224
116protein activation cascade (GO:0072376)3.43255887
117glutamate receptor signaling pathway (GO:0007215)3.42823275
118regulation of norepinephrine secretion (GO:0014061)3.41460661
119glycine transport (GO:0015816)3.38595185
120regulation of synaptic transmission, GABAergic (GO:0032228)3.36174485
121glutamate secretion (GO:0014047)3.35819791
122long-term synaptic potentiation (GO:0060291)3.35243751
123mating behavior (GO:0007617)3.35114178
124oxidative demethylation (GO:0070989)3.32353550
125cAMP biosynthetic process (GO:0006171)3.28310504
126drinking behavior (GO:0042756)3.26247472
127cGMP metabolic process (GO:0046068)3.25191260
128aromatic amino acid family catabolic process (GO:0009074)3.24387144
129learning (GO:0007612)3.22280561
130negative regulation of blood coagulation (GO:0030195)3.21818094
131negative regulation of hemostasis (GO:1900047)3.21818094
132fear response (GO:0042596)3.20667666
133triglyceride homeostasis (GO:0070328)3.19591086
134acylglycerol homeostasis (GO:0055090)3.19591086
135ethanol oxidation (GO:0006069)3.19134202
136neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.17738423
137L-amino acid import (GO:0043092)3.15941981
138regulation of Rap GTPase activity (GO:0032317)3.15653020
139regulation of synaptic transmission, dopaminergic (GO:0032225)3.15286781
140positive regulation of synaptic transmission (GO:0050806)3.14962376
141negative regulation of amino acid transport (GO:0051956)3.12178728
142serine family amino acid catabolic process (GO:0009071)3.08684185
143bile acid and bile salt transport (GO:0015721)3.08517296
144serotonin metabolic process (GO:0042428)3.08105147
145complement activation (GO:0006956)3.06992426
146phosphate ion transmembrane transport (GO:0035435)3.06504242
147cellular potassium ion homeostasis (GO:0030007)3.05194115
148regulation of bile acid biosynthetic process (GO:0070857)3.03812238
149pyrimidine nucleobase catabolic process (GO:0006208)3.03083886
150negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01901597
151phenylpropanoid metabolic process (GO:0009698)2.97892683
152regulation of cholesterol esterification (GO:0010872)2.96943675
153response to methylmercury (GO:0051597)2.95643589
154plasma lipoprotein particle remodeling (GO:0034369)2.92957325
155protein-lipid complex remodeling (GO:0034368)2.92957325
156macromolecular complex remodeling (GO:0034367)2.92957325
157complement activation, classical pathway (GO:0006958)2.91926701
158postsynaptic membrane organization (GO:0001941)2.91558380
159negative regulation of protein activation cascade (GO:2000258)2.91102020
160negative regulation of wound healing (GO:0061045)2.90515703
161low-density lipoprotein particle remodeling (GO:0034374)2.90303545
162reverse cholesterol transport (GO:0043691)2.89950013
163sodium ion export (GO:0071436)2.86072917
164negative regulation of coagulation (GO:0050819)2.82558677
165cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81482421
166positive regulation of blood coagulation (GO:0030194)2.81264044
167positive regulation of hemostasis (GO:1900048)2.81264044
168regulation of humoral immune response (GO:0002920)2.80435964
169high-density lipoprotein particle remodeling (GO:0034375)2.79420311
170amino-acid betaine metabolic process (GO:0006577)2.79259732
171primary amino compound metabolic process (GO:1901160)2.76285335
172steroid catabolic process (GO:0006706)2.74937943
173amino acid import (GO:0043090)2.71236110
174nucleobase catabolic process (GO:0046113)2.70978003
175phospholipid efflux (GO:0033700)2.70901919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83231892
2* RARB_27405468_Chip-Seq_BRAIN_Mouse4.27107693
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46771786
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.18387092
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15859086
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10799096
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96745756
8GBX2_23144817_ChIP-Seq_PC3_Human2.93861843
9DROSHA_22980978_ChIP-Seq_HELA_Human2.88927863
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74908180
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74908180
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73374658
13REST_21632747_ChIP-Seq_MESCs_Mouse2.70371564
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63344334
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62306150
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62109686
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58507907
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54189775
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.44195215
20* EZH2_27304074_Chip-Seq_ESCs_Mouse2.41091182
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37383077
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.34221945
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.32749610
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.28647896
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25984070
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20380222
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19345027
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.17413283
29AR_21572438_ChIP-Seq_LNCaP_Human2.14376496
30LXR_22158963_ChIP-Seq_LIVER_Mouse2.08098871
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.07115839
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98871777
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.95135425
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76836549
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67806286
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67389268
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65975779
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59490542
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55524062
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50095203
41KDM2B_26808549_Chip-Seq_K562_Human1.49247108
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47688632
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44383699
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43812214
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43599691
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39676683
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36793550
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36322172
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36101535
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35706534
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35649709
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33569974
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33418163
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.29630615
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28285569
56SMAD4_21799915_ChIP-Seq_A2780_Human1.28284811
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28016498
58HTT_18923047_ChIP-ChIP_STHdh_Human1.26491030
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25083137
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25051270
61GATA1_22025678_ChIP-Seq_K562_Human1.24321441
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.23565389
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.23184019
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22397781
65AR_19668381_ChIP-Seq_PC3_Human1.21322366
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16747355
67* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16740596
68* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15536079
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14407300
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13019382
71STAT3_23295773_ChIP-Seq_U87_Human1.11045421
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.10672152
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10636454
74* CTCF_27219007_Chip-Seq_Bcells_Human1.09487018
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08129194
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05799513
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05192363
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05136812
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04390561
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04315945
81KLF4_19829295_ChIP-Seq_ESCs_Human1.01620139
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00378859
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99240060
84RXR_22108803_ChIP-Seq_LS180_Human0.99152235
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98931162
86* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98290516
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97085766
88TET1_21490601_ChIP-Seq_MESCs_Mouse0.96257354
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95283687
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94973249
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94869369
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94844580
93AHR_22903824_ChIP-Seq_MCF-7_Human0.94140552
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.94043503
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93848592
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.93015007
97TCF4_23295773_ChIP-Seq_U87_Human0.92973006
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92744417
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91385057
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.90780468
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.90097713
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89909380
103P300_19829295_ChIP-Seq_ESCs_Human0.89742526
104* TAF15_26573619_Chip-Seq_HEK293_Human0.89657858
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89403716
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89123940
107AR_25329375_ChIP-Seq_VCAP_Human0.87832871
108TP53_18474530_ChIP-ChIP_U2OS_Human0.87684330
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.87522530
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85479661
111RUNX2_22187159_ChIP-Seq_PCA_Human0.85250985
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84951838
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84951838
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84356043
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.84192259
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.84163531
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82684639
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82670289
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.82444662
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82032337
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81508047
122BCAT_22108803_ChIP-Seq_LS180_Human0.81069083
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80809084
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80504555
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80442378
126* P53_22387025_ChIP-Seq_ESCs_Mouse0.80199167
127TP53_16413492_ChIP-PET_HCT116_Human0.80192936
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79987448
129HNF4A_19822575_ChIP-Seq_HepG2_Human0.79145632
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79131219
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.78854142
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78343721
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78187838
134* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77690156
135OCT4_19829295_ChIP-Seq_ESCs_Human0.77573450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy9.54680817
2MP0004859_abnormal_synaptic_plasticity6.34226708
3MP0002139_abnormal_hepatobiliary_system4.66392543
4MP0003635_abnormal_synaptic_transmissio4.08440497
5MP0003880_abnormal_central_pattern3.99876012
6MP0005085_abnormal_gallbladder_physiolo3.79271115
7MP0009745_abnormal_behavioral_response3.73391991
8MP0002063_abnormal_learning/memory/cond3.48412179
9MP0005365_abnormal_bile_salt3.37510808
10MP0003868_abnormal_feces_composition3.33808812
11MP0004270_analgesia3.25245589
12MP0003195_calcinosis2.96148482
13MP0002064_seizures2.95778498
14MP0001529_abnormal_vocalization2.93222358
15MP0002138_abnormal_hepatobiliary_system2.79731310
16MP0002572_abnormal_emotion/affect_behav2.77471849
17MP0009046_muscle_twitch2.76198805
18MP0001486_abnormal_startle_reflex2.76127319
19MP0005360_urolithiasis2.72267783
20MP0008875_abnormal_xenobiotic_pharmacok2.63178284
21MP0002909_abnormal_adrenal_gland2.52902087
22MP0002272_abnormal_nervous_system2.43112679
23MP0005423_abnormal_somatic_nervous2.39476793
24MP0001968_abnormal_touch/_nociception2.37681258
25MP0005646_abnormal_pituitary_gland2.14974902
26MP0001501_abnormal_sleep_pattern2.03899366
27MP0002734_abnormal_mechanical_nocicepti2.01839362
28MP0002876_abnormal_thyroid_physiology2.00699148
29MP0004924_abnormal_behavior1.99377003
30MP0005386_behavior/neurological_phenoty1.99377003
31MP0001666_abnormal_nutrient_absorption1.95329488
32MP0003252_abnormal_bile_duct1.89818999
33MP0005409_darkened_coat_color1.88301554
34MP0010329_abnormal_lipoprotein_level1.82648426
35MP0001970_abnormal_pain_threshold1.74567586
36MP0008569_lethality_at_weaning1.69858285
37MP0002733_abnormal_thermal_nociception1.67872907
38MP0004811_abnormal_neuron_physiology1.67303612
39MP0002557_abnormal_social/conspecific_i1.64487144
40MP0001984_abnormal_olfaction1.63082210
41MP0003075_altered_response_to1.54610484
42MP0003011_delayed_dark_adaptation1.52944616
43MP0009780_abnormal_chondrocyte_physiolo1.51908490
44MP0002736_abnormal_nociception_after1.51875201
45MP0001188_hyperpigmentation1.50250124
46MP0001440_abnormal_grooming_behavior1.49550737
47MP0003879_abnormal_hair_cell1.39242014
48MP0002067_abnormal_sensory_capabilities1.39007656
49MP0008874_decreased_physiological_sensi1.37963194
50MP0001986_abnormal_taste_sensitivity1.37775978
51MP0005167_abnormal_blood-brain_barrier1.36198331
52MP0005464_abnormal_platelet_physiology1.35765951
53MP0004885_abnormal_endolymph1.34476740
54MP0004510_myositis1.34138013
55MP0003633_abnormal_nervous_system1.33926307
56MP0010368_abnormal_lymphatic_system1.32359777
57MP0001177_atelectasis1.32314551
58MP0008872_abnormal_physiological_respon1.31678681
59MP0003329_amyloid_beta_deposits1.31122354
60MP0000013_abnormal_adipose_tissue1.31002313
61MP0002066_abnormal_motor_capabilities/c1.26516373
62MP0010234_abnormal_vibrissa_follicle1.22852008
63MP0000955_abnormal_spinal_cord1.20714097
64MP0001905_abnormal_dopamine_level1.20669244
65MP0005187_abnormal_penis_morphology1.19563869
66MP0002184_abnormal_innervation1.17113129
67MP0005248_abnormal_Harderian_gland1.15881047
68MP0002735_abnormal_chemical_nociception1.12912029
69MP0004130_abnormal_muscle_cell1.12888335
70MP0003283_abnormal_digestive_organ1.12610634
71MP0002118_abnormal_lipid_homeostasis1.09674674
72MP0002882_abnormal_neuron_morphology1.07900054
73MP0010386_abnormal_urinary_bladder1.06961545
74MP0008961_abnormal_basal_metabolism1.06520714
75MP0003690_abnormal_glial_cell1.05052624
76MP0009697_abnormal_copulation1.04867021
77MP0004085_abnormal_heartbeat1.04147190
78MP0002249_abnormal_larynx_morphology1.02168244
79MP0009840_abnormal_foam_cell1.02132229
80MP0004019_abnormal_vitamin_homeostasis1.01760918
81MP0003631_nervous_system_phenotype1.01635755
82MP0004858_abnormal_nervous_system0.99844958
83MP0000778_abnormal_nervous_system0.99234878
84MP0002090_abnormal_vision0.97693026
85MP0000569_abnormal_digit_pigmentation0.93594813
86MP0002069_abnormal_eating/drinking_beha0.93451783
87MP0003191_abnormal_cellular_cholesterol0.93359632
88MP0005535_abnormal_body_temperature0.92070675
89MP0000920_abnormal_myelination0.88785784
90MP0001502_abnormal_circadian_rhythm0.87448070
91MP0002152_abnormal_brain_morphology0.86193690
92MP0005332_abnormal_amino_acid0.85645489
93MP0004142_abnormal_muscle_tone0.82631001
94MP0000751_myopathy0.76114514
95MP0003137_abnormal_impulse_conducting0.72774323
96MP0005394_taste/olfaction_phenotype0.72175425
97MP0005499_abnormal_olfactory_system0.72175425
98MP0005645_abnormal_hypothalamus_physiol0.71011317
99MP0003787_abnormal_imprinting0.70315851
100MP0002229_neurodegeneration0.68578626
101MP0003634_abnormal_glial_cell0.66008363
102MP0000631_abnormal_neuroendocrine_gland0.65962666
103MP0010030_abnormal_orbit_morphology0.65887815
104MP0005166_decreased_susceptibility_to0.65158363
105MP0000604_amyloidosis0.60968906
106MP0003638_abnormal_response/metabolism_0.59879110
107MP0004147_increased_porphyrin_level0.57207666
108MP0000609_abnormal_liver_physiology0.56868693
109MP0001963_abnormal_hearing_physiology0.55292236
110MP0001664_abnormal_digestion0.54818831
111MP0004043_abnormal_pH_regulation0.53827065
112MP0003122_maternal_imprinting0.53362609
113MP0003632_abnormal_nervous_system0.51998416
114MP0001485_abnormal_pinna_reflex0.51201312
115MP0000003_abnormal_adipose_tissue0.49417788
116MP0006276_abnormal_autonomic_nervous0.47929128
117MP0005551_abnormal_eye_electrophysiolog0.47638380
118MP0001943_abnormal_respiration0.46414718
119MP0003956_abnormal_body_size0.44525298
120MP0003303_peritoneal_inflammation0.44392407
121MP0004742_abnormal_vestibular_system0.44214815
122MP0005620_abnormal_muscle_contractility0.39724328
123MP0010769_abnormal_survival0.38309235
124MP0005623_abnormal_meninges_morphology0.36517445
125MP0000230_abnormal_systemic_arterial0.36495227
126MP0010770_preweaning_lethality0.36323546
127MP0002082_postnatal_lethality0.36323546
128MP0002752_abnormal_somatic_nervous0.36312995
129MP0003172_abnormal_lysosome_physiology0.35732842
130MP0010768_mortality/aging0.35270304
131MP0005584_abnormal_enzyme/coenzyme_acti0.34365555
132MP0001299_abnormal_eye_distance/0.33791055
133MP0004233_abnormal_muscle_weight0.33545255
134MP0000534_abnormal_ureter_morphology0.33270153

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.83549212
2Focal motor seizures (HP:0011153)7.66692932
3Deep venous thrombosis (HP:0002625)7.55726840
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54444331
5Complement deficiency (HP:0004431)6.42624753
6Prolonged partial thromboplastin time (HP:0003645)6.05199263
7Focal seizures (HP:0007359)5.65413286
8Abnormality of complement system (HP:0005339)5.00484009
9Resting tremor (HP:0002322)4.86034582
10Torticollis (HP:0000473)4.77863741
11Systemic lupus erythematosus (HP:0002725)4.75818646
12Annular pancreas (HP:0001734)4.73733471
13Hyperlipoproteinemia (HP:0010980)4.61247186
14Poor eye contact (HP:0000817)4.27801764
15Hypobetalipoproteinemia (HP:0003563)4.14542042
16Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12310624
17Visual hallucinations (HP:0002367)4.09802480
18Focal dystonia (HP:0004373)4.08298537
19Joint hemorrhage (HP:0005261)4.05014231
20Action tremor (HP:0002345)4.04582072
21Craniofacial dystonia (HP:0012179)4.03656635
22Ankle clonus (HP:0011448)3.97794085
23Anxiety (HP:0000739)3.96851325
24Glomerulonephritis (HP:0000099)3.87970495
25Abnormal social behavior (HP:0012433)3.86530152
26Impaired social interactions (HP:0000735)3.86530152
27Ankyloglossia (HP:0010296)3.82710465
28Impaired vibration sensation in the lower limbs (HP:0002166)3.81612375
29Menorrhagia (HP:0000132)3.70862171
30Depression (HP:0000716)3.68193058
31Spontaneous abortion (HP:0005268)3.63345799
32Broad-based gait (HP:0002136)3.63187839
33Abnormality of the common coagulation pathway (HP:0010990)3.62332698
34Dysdiadochokinesis (HP:0002075)3.49948165
35Abnormality of binocular vision (HP:0011514)3.49154648
36Diplopia (HP:0000651)3.49154648
37Xanthomatosis (HP:0000991)3.48543107
38Epileptic encephalopathy (HP:0200134)3.43554878
39Urinary bladder sphincter dysfunction (HP:0002839)3.39327748
40Generalized tonic-clonic seizures (HP:0002069)3.37793668
41Purpura (HP:0000979)3.34443095
42Papilledema (HP:0001085)3.33402355
43Stereotypic behavior (HP:0000733)3.23131300
44Gaze-evoked nystagmus (HP:0000640)3.19894955
45Pointed chin (HP:0000307)3.19596234
46Absence seizures (HP:0002121)3.17490021
47Febrile seizures (HP:0002373)3.17273382
48Lower limb amyotrophy (HP:0007210)3.15835613
49Urinary urgency (HP:0000012)3.15007605
50Osteomalacia (HP:0002749)3.11552293
51Polygenic inheritance (HP:0010982)3.09737472
52Scanning speech (HP:0002168)3.07513651
53Prolonged QT interval (HP:0001657)3.06653111
54Postural instability (HP:0002172)3.02033435
55Dysmetric saccades (HP:0000641)3.01771065
56Dialeptic seizures (HP:0011146)2.98404953
57Dysmetria (HP:0001310)2.97456440
58Intrahepatic cholestasis (HP:0001406)2.94982000
59Atrioventricular block (HP:0001678)2.93552596
60Abnormality of oral frenula (HP:0000190)2.86218465
61Truncal ataxia (HP:0002078)2.81303639
62Conjugated hyperbilirubinemia (HP:0002908)2.79924262
63Atonic seizures (HP:0010819)2.77950907
64Abnormality of pyrimidine metabolism (HP:0004353)2.77258699
65Abnormal eating behavior (HP:0100738)2.74326932
66Abnormal EKG (HP:0003115)2.72646182
67Gingival bleeding (HP:0000225)2.72441603
68Intention tremor (HP:0002080)2.71167994
69Spastic gait (HP:0002064)2.69819445
70Supranuclear gaze palsy (HP:0000605)2.69262644
71Prolonged bleeding time (HP:0003010)2.66386496
72Megalencephaly (HP:0001355)2.65237169
73Limb dystonia (HP:0002451)2.63871289
74Impaired smooth pursuit (HP:0007772)2.63074768
75Progressive cerebellar ataxia (HP:0002073)2.62600857
76Nephritis (HP:0000123)2.61013417
77Distal lower limb amyotrophy (HP:0008944)2.60653146
78Impaired vibratory sensation (HP:0002495)2.59607224
79Recurrent gram-negative bacterial infections (HP:0005420)2.55173127
80Increased mean platelet volume (HP:0011877)2.54983573
81Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50534396
82Bradykinesia (HP:0002067)2.50045790
83Heart block (HP:0012722)2.45482171
84Limb hypertonia (HP:0002509)2.43830227
85Clonus (HP:0002169)2.43441108
86Mutism (HP:0002300)2.42696065
87Distal upper limb amyotrophy (HP:0007149)2.38242887
88Upper limb amyotrophy (HP:0009129)2.38242887
89Abnormality of the lower motor neuron (HP:0002366)2.36403489
90Abnormal platelet volume (HP:0011876)2.34754724
91Abnormality of the intrinsic pathway (HP:0010989)2.29101483
92Arthropathy (HP:0003040)2.27944481
93Ventricular fibrillation (HP:0001663)2.27585246
94Epistaxis (HP:0000421)2.27285977
95Incomplete penetrance (HP:0003829)2.25534601
96Rickets (HP:0002748)2.24521665
97Axonal loss (HP:0003447)2.23369798
98Abnormal atrioventricular conduction (HP:0005150)2.23311133
99Amblyopia (HP:0000646)2.23105835
100Hypolipoproteinemia (HP:0010981)2.19380881
101Abnormality of ocular smooth pursuit (HP:0000617)2.17895691
102Lower limb muscle weakness (HP:0007340)2.16501543
103Status epilepticus (HP:0002133)2.16210810
104Obstructive sleep apnea (HP:0002870)2.15868627
105Hyperventilation (HP:0002883)2.15862227
106Progressive inability to walk (HP:0002505)2.15433589
107Truncus arteriosus (HP:0001660)2.13498043
108Epidermoid cyst (HP:0200040)2.10956722
109Hemiplegia (HP:0002301)2.10636344
110Neurofibrillary tangles (HP:0002185)2.08661256
111Abnormal gallbladder physiology (HP:0012438)2.08069983
112Cholecystitis (HP:0001082)2.08069983
113Polyphagia (HP:0002591)2.07755469
114Termporal pattern (HP:0011008)2.07315350
115Insidious onset (HP:0003587)2.07315350
116Abnormality of the periventricular white matter (HP:0002518)2.07038169
117Hemiparesis (HP:0001269)2.06095283
118Lower limb asymmetry (HP:0100559)2.05519068
119Hypophosphatemic rickets (HP:0004912)2.01111690
120Neuronal loss in central nervous system (HP:0002529)2.01090007
121Bowel incontinence (HP:0002607)2.00963337
122Bundle branch block (HP:0011710)1.99824139
123Abnormality of saccadic eye movements (HP:0000570)1.96035975
124Fair hair (HP:0002286)1.94295574
125Dysphonia (HP:0001618)1.92969238
126Generalized hypopigmentation of hair (HP:0011358)1.92608136
127Poikilocytosis (HP:0004447)1.92541572
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91848826
129Cerebral inclusion bodies (HP:0100314)1.91776592
130Onion bulb formation (HP:0003383)1.90705679
131Blue irides (HP:0000635)1.88636357
132Obsessive-compulsive behavior (HP:0000722)1.88407835
133Spinal canal stenosis (HP:0003416)1.87436115
134Petechiae (HP:0000967)1.86977323
135Genetic anticipation (HP:0003743)1.86249816
136Insomnia (HP:0100785)1.86163882
137Fetal akinesia sequence (HP:0001989)1.85509054
138Pulmonary embolism (HP:0002204)1.84974397
139Primary atrial arrhythmia (HP:0001692)1.84117331
140EEG with generalized epileptiform discharges (HP:0011198)1.83636555
141Epileptiform EEG discharges (HP:0011182)1.83554290
142Tetraplegia (HP:0002445)1.83470657
143Abnormal large intestine physiology (HP:0012700)1.83373468
144Hypsarrhythmia (HP:0002521)1.82788305
145Rigidity (HP:0002063)1.82719433
146Atrial fibrillation (HP:0005110)1.80926795
147Akinesia (HP:0002304)1.77822962
148Generalized aminoaciduria (HP:0002909)1.77346164
149Mitral stenosis (HP:0001718)1.75731670
150Hyperammonemia (HP:0001987)1.73455396
151Morphological abnormality of the pyramidal tract (HP:0002062)1.72598073
152Irritability (HP:0000737)1.72398352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA48.22264969
2NTRK33.87215401
3MAP3K93.54129446
4CASK3.19526282
5KSR22.94709537
6DAPK22.94452425
7PRKD32.64339095
8RIPK42.62594147
9CAMKK12.50802830
10MINK12.08013940
11NTRK11.97760671
12MAP3K131.96757405
13FES1.94372137
14TAOK11.92110527
15ARAF1.89766839
16NTRK21.82703067
17KSR11.79855679
18MARK11.78503574
19MAP3K41.74082295
20MAP3K21.65547893
21PAK61.63871112
22CAMKK21.63333434
23CDK51.60716323
24DAPK11.54661755
25TYRO31.46099961
26LATS21.45388996
27TNIK1.43382948
28SIK21.37818250
29RAF11.29981240
30MAP2K71.18894487
31PRPF4B1.14057155
32PINK11.06269095
33MAP3K111.04907158
34SGK4941.03672272
35SGK2231.03672272
36STK381.02877824
37PRKCH1.02231186
38BMPR21.00684667
39MAP2K40.98807639
40MAPK120.98728740
41NEK10.93800369
42MARK20.90690359
43CAMK1G0.90626661
44SGK20.89774178
45SGK30.88895790
46STK110.86957864
47PKN10.84126461
48CDK180.84034196
49CDK150.84001402
50UHMK10.82292589
51RIPK10.82103803
52PDPK10.82013545
53SGK10.81936753
54RET0.81626650
55PRKCG0.81240860
56CDK140.80445379
57MAP3K10.79909721
58DYRK1A0.79553220
59ALK0.78550091
60EPHA30.75282981
61PDK10.75171685
62CCNB10.74378206
63CDK11A0.73017732
64CAMK10.71970546
65TRIB30.70929975
66CAMK1D0.69681910
67CAMK2A0.68872969
68PIK3CA0.68663135
69PRKG10.67961549
70PAK30.67409181
71CAMK2B0.66551058
72PNCK0.65601102
73TNK20.65247994
74SYK0.65043738
75JAK20.64648638
76MAP2K10.64423113
77PIK3CG0.63517122
78PTK2B0.63396004
79MAPK130.63271794
80NEK60.62915593
81BRSK10.60369576
82GRK50.56736144
83DAPK30.56665224
84LMTK20.56566174
85FYN0.55463216
86RPS6KA30.54453910
87PRKD20.54403508
88ERBB20.54323089
89PRKCZ0.53759701
90SCYL20.51098728
91DMPK0.50022637
92JAK10.49964274
93CSNK1D0.49307862
94MAP3K120.49256400
95CAMK40.47656698
96MOS0.46787143
97MAPK100.46174163
98MAP3K50.45642196
99WNK10.42325593
100PHKG20.42259932
101PHKG10.42259932
102CDK190.42008029
103FGFR20.39949358
104INSRR0.39932733
105BRAF0.39709609
106PLK20.38113319
107SRC0.36277792
108OXSR10.35948837
109PDGFRA0.35073455
110PRKCB0.34352945
111CAMK2G0.31541349
112HCK0.30206689
113CDC42BPA0.29894116
114PRKCE0.29733967
115CSNK1A10.28789241
116CAMK2D0.28776658
117PRKACG0.28629376
118CSNK1G20.27941759
119BMX0.26771831
120RPS6KA20.26752802
121MAPK80.26422679
122PRKACA0.26045726
123PRKD10.24562974
124PRKCA0.24095413

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.88922591
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.45494606
3Complement and coagulation cascades_Homo sapiens_hsa046103.34412020
4Morphine addiction_Homo sapiens_hsa050322.96854432
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90819079
6Cocaine addiction_Homo sapiens_hsa050302.81919663
7Amphetamine addiction_Homo sapiens_hsa050312.80953086
8Circadian entrainment_Homo sapiens_hsa047132.75943722
9GABAergic synapse_Homo sapiens_hsa047272.74387161
10Nicotine addiction_Homo sapiens_hsa050332.69039863
11Long-term potentiation_Homo sapiens_hsa047202.60088518
12Synaptic vesicle cycle_Homo sapiens_hsa047212.56987751
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56878583
14Glutamatergic synapse_Homo sapiens_hsa047242.49236395
15Dopaminergic synapse_Homo sapiens_hsa047282.47654799
16Retinol metabolism_Homo sapiens_hsa008302.46925288
17Caffeine metabolism_Homo sapiens_hsa002322.41320980
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31082213
19Cholinergic synapse_Homo sapiens_hsa047252.29186067
20Steroid hormone biosynthesis_Homo sapiens_hsa001402.10737687
21Renin secretion_Homo sapiens_hsa049242.06771888
22Salivary secretion_Homo sapiens_hsa049702.04631352
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03979126
24Chemical carcinogenesis_Homo sapiens_hsa052041.99331656
25Nitrogen metabolism_Homo sapiens_hsa009101.95691228
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91631573
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88063554
28Oxytocin signaling pathway_Homo sapiens_hsa049211.79864462
29Gastric acid secretion_Homo sapiens_hsa049711.78638988
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75729721
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74751010
32Histidine metabolism_Homo sapiens_hsa003401.72713701
33Insulin secretion_Homo sapiens_hsa049111.70549516
34Calcium signaling pathway_Homo sapiens_hsa040201.67598840
35Gap junction_Homo sapiens_hsa045401.67054939
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60923704
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.55413467
38Serotonergic synapse_Homo sapiens_hsa047261.55265130
39Phenylalanine metabolism_Homo sapiens_hsa003601.52491971
40Long-term depression_Homo sapiens_hsa047301.49620162
41GnRH signaling pathway_Homo sapiens_hsa049121.46750923
42Fatty acid degradation_Homo sapiens_hsa000711.42093769
43cAMP signaling pathway_Homo sapiens_hsa040241.40919860
44Linoleic acid metabolism_Homo sapiens_hsa005911.39339816
45Taste transduction_Homo sapiens_hsa047421.34550786
46Vitamin B6 metabolism_Homo sapiens_hsa007501.34115923
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33881838
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30366537
49Tryptophan metabolism_Homo sapiens_hsa003801.29418932
50beta-Alanine metabolism_Homo sapiens_hsa004101.24277565
51Glioma_Homo sapiens_hsa052141.20789324
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19905714
53Tyrosine metabolism_Homo sapiens_hsa003501.13497502
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10765896
55PPAR signaling pathway_Homo sapiens_hsa033201.10578641
56Starch and sucrose metabolism_Homo sapiens_hsa005001.06769896
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.05579266
58Estrogen signaling pathway_Homo sapiens_hsa049151.05439995
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05262602
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05117540
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04815083
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03498998
63Type II diabetes mellitus_Homo sapiens_hsa049301.01595634
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.99249866
65Alcoholism_Homo sapiens_hsa050340.98996511
66Melanogenesis_Homo sapiens_hsa049160.95152372
67Non-small cell lung cancer_Homo sapiens_hsa052230.94528971
68Peroxisome_Homo sapiens_hsa041460.94049339
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93189944
70Arginine and proline metabolism_Homo sapiens_hsa003300.90164894
71ErbB signaling pathway_Homo sapiens_hsa040120.89824981
72Oocyte meiosis_Homo sapiens_hsa041140.88838076
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85775481
74Arachidonic acid metabolism_Homo sapiens_hsa005900.84798529
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84773617
76Phototransduction_Homo sapiens_hsa047440.84027446
77Dilated cardiomyopathy_Homo sapiens_hsa054140.80838120
78Rap1 signaling pathway_Homo sapiens_hsa040150.79969099
79Axon guidance_Homo sapiens_hsa043600.79499923
80Dorso-ventral axis formation_Homo sapiens_hsa043200.79037907
81ABC transporters_Homo sapiens_hsa020100.78601403
82Staphylococcus aureus infection_Homo sapiens_hsa051500.78477785
83Pancreatic secretion_Homo sapiens_hsa049720.73503025
84Thyroid hormone synthesis_Homo sapiens_hsa049180.73057298
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72459861
86Type I diabetes mellitus_Homo sapiens_hsa049400.71451226
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70063201
88VEGF signaling pathway_Homo sapiens_hsa043700.69440988
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68293849
90Cardiac muscle contraction_Homo sapiens_hsa042600.68018861
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.67115333
92Choline metabolism in cancer_Homo sapiens_hsa052310.66659979
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66533626
94MAPK signaling pathway_Homo sapiens_hsa040100.66253198
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64522119
96Chemokine signaling pathway_Homo sapiens_hsa040620.63755088
97Collecting duct acid secretion_Homo sapiens_hsa049660.61163033
98mTOR signaling pathway_Homo sapiens_hsa041500.59273123
99Bile secretion_Homo sapiens_hsa049760.59025486
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58827629
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58641486
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.55972293
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54782745
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54413539
105Ras signaling pathway_Homo sapiens_hsa040140.53801705
106Prion diseases_Homo sapiens_hsa050200.51593898
107Endometrial cancer_Homo sapiens_hsa052130.51263337
108Glycerolipid metabolism_Homo sapiens_hsa005610.50636890
109Platelet activation_Homo sapiens_hsa046110.49661622
110Fatty acid biosynthesis_Homo sapiens_hsa000610.49239445
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48772731
112Endocytosis_Homo sapiens_hsa041440.48055381
113Glucagon signaling pathway_Homo sapiens_hsa049220.47547617
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47490017
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46927671
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46324844
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44690732
118Thyroid cancer_Homo sapiens_hsa052160.44515677
119Renal cell carcinoma_Homo sapiens_hsa052110.41706688
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41207667
121Fat digestion and absorption_Homo sapiens_hsa049750.40033805
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39841136
123Ovarian steroidogenesis_Homo sapiens_hsa049130.39441772
124Arginine biosynthesis_Homo sapiens_hsa002200.38462733
125African trypanosomiasis_Homo sapiens_hsa051430.38003649
126Fatty acid metabolism_Homo sapiens_hsa012120.37195186
127Sulfur relay system_Homo sapiens_hsa041220.36441633
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35718810
129Insulin signaling pathway_Homo sapiens_hsa049100.35635671
130Vibrio cholerae infection_Homo sapiens_hsa051100.35533674
131Butanoate metabolism_Homo sapiens_hsa006500.34105020
132Circadian rhythm_Homo sapiens_hsa047100.33957291
133Inositol phosphate metabolism_Homo sapiens_hsa005620.33362992
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.30258855
135Pertussis_Homo sapiens_hsa051330.29391036
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.28978290
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28782692
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.27079776
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26408423
140Biosynthesis of amino acids_Homo sapiens_hsa012300.25366778
141Pyruvate metabolism_Homo sapiens_hsa006200.25063768
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24953721
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23929205

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