GPRASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28846303
2synaptic vesicle maturation (GO:0016188)5.92849087
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.71134926
4locomotory exploration behavior (GO:0035641)5.59205745
5vocalization behavior (GO:0071625)5.43984469
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.27619793
7synaptic vesicle exocytosis (GO:0016079)5.23539113
8regulation of synaptic vesicle exocytosis (GO:2000300)5.06777688
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97728343
10glutamate secretion (GO:0014047)4.91548206
11regulation of glutamate receptor signaling pathway (GO:1900449)4.81524858
12neuron cell-cell adhesion (GO:0007158)4.75991615
13neurotransmitter secretion (GO:0007269)4.71492601
14layer formation in cerebral cortex (GO:0021819)4.64974334
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.57148512
16protein localization to synapse (GO:0035418)4.52977984
17regulation of synaptic vesicle transport (GO:1902803)4.51896821
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.49606821
19exploration behavior (GO:0035640)4.47555668
20gamma-aminobutyric acid transport (GO:0015812)4.31860088
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.23485482
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22664327
23regulation of neuronal synaptic plasticity (GO:0048168)4.21303105
24cerebellar granule cell differentiation (GO:0021707)4.11442734
25regulation of synapse structural plasticity (GO:0051823)4.09832797
26proline transport (GO:0015824)4.08282086
27dendritic spine morphogenesis (GO:0060997)4.02860317
28neuronal action potential propagation (GO:0019227)4.02027862
29glutamate receptor signaling pathway (GO:0007215)4.01880340
30cellular potassium ion homeostasis (GO:0030007)3.97186962
31synaptic transmission, glutamatergic (GO:0035249)3.96409309
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.89509194
33neurotransmitter transport (GO:0006836)3.89308950
34activation of protein kinase A activity (GO:0034199)3.86325950
35neuron-neuron synaptic transmission (GO:0007270)3.85020088
36neurotransmitter-gated ion channel clustering (GO:0072578)3.82072384
37long-term memory (GO:0007616)3.81285161
38neuron recognition (GO:0008038)3.80364295
39presynaptic membrane organization (GO:0097090)3.78469485
40L-amino acid import (GO:0043092)3.73910436
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69499868
42sodium ion export (GO:0071436)3.66904708
43transmission of nerve impulse (GO:0019226)3.65870227
44potassium ion import (GO:0010107)3.63709681
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63356161
46cerebellar Purkinje cell differentiation (GO:0021702)3.62089308
47regulation of neurotransmitter levels (GO:0001505)3.57016136
48synaptic vesicle endocytosis (GO:0048488)3.56518206
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.55943339
50neuromuscular process controlling posture (GO:0050884)3.54633977
51detection of calcium ion (GO:0005513)3.54311287
52positive regulation of membrane potential (GO:0045838)3.52648949
53axonal fasciculation (GO:0007413)3.49397573
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.48763580
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48586663
56potassium ion homeostasis (GO:0055075)3.47550024
57positive regulation of synapse maturation (GO:0090129)3.45008918
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44548542
59regulation of voltage-gated calcium channel activity (GO:1901385)3.42328714
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40320799
61dendrite morphogenesis (GO:0048813)3.40222535
62regulation of postsynaptic membrane potential (GO:0060078)3.39602897
63vesicle transport along microtubule (GO:0047496)3.38751715
64regulation of ARF protein signal transduction (GO:0032012)3.37874627
65neuromuscular process controlling balance (GO:0050885)3.37850710
66prepulse inhibition (GO:0060134)3.34816994
67postsynaptic membrane organization (GO:0001941)3.34625670
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34588789
69auditory behavior (GO:0031223)3.32493110
70glycine transport (GO:0015816)3.32390633
71response to auditory stimulus (GO:0010996)3.30641249
72cell communication by electrical coupling (GO:0010644)3.28743315
73regulation of neurotransmitter secretion (GO:0046928)3.26900781
74positive regulation of dendritic spine development (GO:0060999)3.26837805
75amino acid import (GO:0043090)3.26383801
76regulation of synapse maturation (GO:0090128)3.25734627
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.25716188
78positive regulation of neurotransmitter secretion (GO:0001956)3.24864168
79regulation of synaptic plasticity (GO:0048167)3.24818883
80negative regulation of dendrite morphogenesis (GO:0050774)3.22998817
81regulation of vesicle fusion (GO:0031338)3.22756716
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21711708
83response to histamine (GO:0034776)3.19133484
84regulation of dendritic spine morphogenesis (GO:0061001)3.18975661
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17843368
86cerebellar Purkinje cell layer development (GO:0021680)3.16369794
87neuronal ion channel clustering (GO:0045161)3.16256876
88synapse assembly (GO:0007416)3.14643854
89mating behavior (GO:0007617)3.14623681
90long-term synaptic potentiation (GO:0060291)3.14551389
91membrane depolarization during action potential (GO:0086010)3.13915026
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10635023
93neurotransmitter uptake (GO:0001504)3.10191626
94membrane hyperpolarization (GO:0060081)3.10125830
95intraspecies interaction between organisms (GO:0051703)3.09383861
96social behavior (GO:0035176)3.09383861
97cellular sodium ion homeostasis (GO:0006883)3.09303808
98positive regulation of dendritic spine morphogenesis (GO:0061003)3.06611328
99regulation of neurotransmitter transport (GO:0051588)3.05917790
100central nervous system myelination (GO:0022010)3.05292744
101axon ensheathment in central nervous system (GO:0032291)3.05292744
102innervation (GO:0060384)3.04754651
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03734682
104organelle transport along microtubule (GO:0072384)3.03237262
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01408228
106neuromuscular synaptic transmission (GO:0007274)3.00922022
107behavioral defense response (GO:0002209)3.00800086
108behavioral fear response (GO:0001662)3.00800086
109cell migration in hindbrain (GO:0021535)3.00563609
110membrane depolarization (GO:0051899)3.00203810
111regulation of synaptic transmission, GABAergic (GO:0032228)3.00201017
112presynaptic membrane assembly (GO:0097105)2.98802241
113regulation of dendritic spine development (GO:0060998)2.98247584
114startle response (GO:0001964)2.97616086
115positive regulation of potassium ion transmembrane transport (GO:1901381)2.97041821
116learning (GO:0007612)2.96853960
117cell differentiation in hindbrain (GO:0021533)2.94051319
118synapse organization (GO:0050808)2.92944932
119synaptic transmission (GO:0007268)2.92922161
120positive regulation of neurotransmitter transport (GO:0051590)2.92805873
121positive regulation of synaptic transmission (GO:0050806)2.92777339
122dendritic spine organization (GO:0097061)2.91841884
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91454293
124neuromuscular process (GO:0050905)2.90709166
125axon cargo transport (GO:0008088)2.89850190
126regulation of synaptic transmission (GO:0050804)2.85518274
127chemosensory behavior (GO:0007635)2.85126161
128mechanosensory behavior (GO:0007638)2.83051692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.26386307
2GBX2_23144817_ChIP-Seq_PC3_Human3.41957332
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02627043
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96475993
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93001145
6REST_21632747_ChIP-Seq_MESCs_Mouse2.81051670
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60381597
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60381597
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52873697
10DROSHA_22980978_ChIP-Seq_HELA_Human2.52367373
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.52167896
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48146818
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47964452
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46913109
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44263648
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.43987675
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43161699
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38510876
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34509393
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.30720974
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22347055
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20512834
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.19497550
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18638277
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.18257376
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.10709895
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08240990
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91538138
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85549240
30AR_21572438_ChIP-Seq_LNCaP_Human1.85306986
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83792989
32TAF15_26573619_Chip-Seq_HEK293_Human1.80568939
33SMAD4_21799915_ChIP-Seq_A2780_Human1.67038507
34ZNF274_21170338_ChIP-Seq_K562_Hela1.66369597
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64280043
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63721346
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.49244987
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44200641
39SOX2_21211035_ChIP-Seq_LN229_Gbm1.37935659
40IGF1R_20145208_ChIP-Seq_DFB_Human1.36033858
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34013955
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33872495
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.33098267
44P300_19829295_ChIP-Seq_ESCs_Human1.32173120
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31439907
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30305361
47STAT3_23295773_ChIP-Seq_U87_Human1.27957269
48AR_19668381_ChIP-Seq_PC3_Human1.27588315
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.26794190
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26532845
51AR_25329375_ChIP-Seq_VCAP_Human1.24526004
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.23364752
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22628888
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22422657
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21721149
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21080511
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.20062450
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17596080
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16838391
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15643737
61RNF2_27304074_Chip-Seq_NSC_Mouse1.15197437
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14971464
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13348546
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12773308
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12558777
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.12555220
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12520253
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12520253
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10825065
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10053933
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09897190
72TCF4_23295773_ChIP-Seq_U87_Human1.09787493
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09588447
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.09197806
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05890113
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04980394
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04650051
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04224988
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.03771904
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03179642
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03022756
82KDM2B_26808549_Chip-Seq_K562_Human1.02695099
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01969526
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01749458
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.01743238
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00662044
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99605242
88AHR_22903824_ChIP-Seq_MCF-7_Human0.99248559
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98916521
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.98863571
91RUNX2_22187159_ChIP-Seq_PCA_Human0.98300116
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97944367
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97511083
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95336092
95KDM2B_26808549_Chip-Seq_REH_Human0.94234031
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94163805
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.93231874
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93187489
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91977793
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91431609
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91266619
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91254030
103FUS_26573619_Chip-Seq_HEK293_Human0.91138896
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91099135
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89384041
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88676683
107FLI1_21867929_ChIP-Seq_TH2_Mouse0.87238872
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86243416
109BCAT_22108803_ChIP-Seq_LS180_Human0.85923950
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84983576
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84795864
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84709001
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84701891
114TP53_16413492_ChIP-PET_HCT116_Human0.84220735
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.84045415
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83939940
117JUN_21703547_ChIP-Seq_K562_Human0.82879272
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.82631203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.96463184
2MP0003880_abnormal_central_pattern4.72726369
3MP0003635_abnormal_synaptic_transmissio4.06877850
4MP0004270_analgesia3.43471334
5* MP0009745_abnormal_behavioral_response3.28424415
6MP0002063_abnormal_learning/memory/cond3.19993754
7MP0009046_muscle_twitch3.19767486
8MP0005423_abnormal_somatic_nervous3.17249892
9MP0002064_seizures3.12938445
10MP0001968_abnormal_touch/_nociception2.89106393
11MP0002572_abnormal_emotion/affect_behav2.73102071
12MP0002734_abnormal_mechanical_nocicepti2.59509341
13MP0002272_abnormal_nervous_system2.51371569
14MP0001486_abnormal_startle_reflex2.45191763
15MP0001501_abnormal_sleep_pattern2.36224289
16MP0002822_catalepsy2.30741718
17MP0003122_maternal_imprinting2.21904631
18MP0001440_abnormal_grooming_behavior2.18800208
19MP0002736_abnormal_nociception_after2.08690794
20MP0002733_abnormal_thermal_nociception2.06964650
21MP0006276_abnormal_autonomic_nervous2.06878551
22MP0002909_abnormal_adrenal_gland2.04636749
23MP0002735_abnormal_chemical_nociception1.99233123
24MP0002067_abnormal_sensory_capabilities1.97466258
25MP0009780_abnormal_chondrocyte_physiolo1.97117047
26MP0001970_abnormal_pain_threshold1.94019242
27MP0003787_abnormal_imprinting1.93355772
28MP0002184_abnormal_innervation1.88178873
29MP0005646_abnormal_pituitary_gland1.85127323
30MP0000778_abnormal_nervous_system1.82825138
31MP0005645_abnormal_hypothalamus_physiol1.82302683
32MP0002557_abnormal_social/conspecific_i1.81491210
33MP0008569_lethality_at_weaning1.80963703
34MP0004924_abnormal_behavior1.77778810
35MP0005386_behavior/neurological_phenoty1.77778810
36MP0004811_abnormal_neuron_physiology1.77527412
37MP0003329_amyloid_beta_deposits1.67436144
38MP0004858_abnormal_nervous_system1.63089441
39MP0000955_abnormal_spinal_cord1.61933950
40MP0004885_abnormal_endolymph1.56345004
41MP0001984_abnormal_olfaction1.53364780
42MP0002882_abnormal_neuron_morphology1.43191482
43MP0001529_abnormal_vocalization1.42630274
44* MP0002066_abnormal_motor_capabilities/c1.39785121
45MP0003879_abnormal_hair_cell1.37194627
46MP0001502_abnormal_circadian_rhythm1.33735700
47MP0004142_abnormal_muscle_tone1.30509373
48MP0000569_abnormal_digit_pigmentation1.28345356
49MP0003633_abnormal_nervous_system1.26998099
50MP0003283_abnormal_digestive_organ1.23929339
51MP0001905_abnormal_dopamine_level1.19267441
52MP0000013_abnormal_adipose_tissue1.14896433
53MP0002152_abnormal_brain_morphology1.14519367
54MP0008877_abnormal_DNA_methylation1.09582514
55MP0004145_abnormal_muscle_electrophysio1.07869442
56MP0000751_myopathy1.07091089
57MP0003631_nervous_system_phenotype1.06336276
58MP0005551_abnormal_eye_electrophysiolog1.05638722
59MP0001986_abnormal_taste_sensitivity1.05108878
60MP0010386_abnormal_urinary_bladder1.03611547
61MP0003121_genomic_imprinting1.02220597
62MP0002229_neurodegeneration1.02205236
63MP0008961_abnormal_basal_metabolism1.01813241
64MP0003123_paternal_imprinting0.99412552
65MP0001188_hyperpigmentation0.96058311
66MP0000631_abnormal_neuroendocrine_gland0.95534380
67MP0002069_abnormal_eating/drinking_beha0.94670107
68MP0008872_abnormal_physiological_respon0.92354967
69MP0002638_abnormal_pupillary_reflex0.91633085
70MP0001177_atelectasis0.91250095
71MP0005499_abnormal_olfactory_system0.88946879
72MP0005394_taste/olfaction_phenotype0.88946879
73MP0003634_abnormal_glial_cell0.88626019
74MP0003690_abnormal_glial_cell0.88192419
75MP0006072_abnormal_retinal_apoptosis0.85150595
76MP0004742_abnormal_vestibular_system0.85023069
77MP0001485_abnormal_pinna_reflex0.82711190
78MP0005535_abnormal_body_temperature0.82630866
79MP0004085_abnormal_heartbeat0.82295669
80MP0002837_dystrophic_cardiac_calcinosis0.81397782
81MP0004233_abnormal_muscle_weight0.81125311
82MP0003632_abnormal_nervous_system0.79193609
83MP0002752_abnormal_somatic_nervous0.76923018
84MP0001299_abnormal_eye_distance/0.75471616
85MP0008874_decreased_physiological_sensi0.75114527
86MP0001963_abnormal_hearing_physiology0.71956396
87MP0002090_abnormal_vision0.71830075
88MP0004130_abnormal_muscle_cell0.70315688
89MP0003137_abnormal_impulse_conducting0.67624791
90MP0002928_abnormal_bile_duct0.66913679
91MP0004215_abnormal_myocardial_fiber0.66412513
92MP0005623_abnormal_meninges_morphology0.64987589
93MP0000920_abnormal_myelination0.64315876
94MP0005187_abnormal_penis_morphology0.63453686
95MP0000604_amyloidosis0.63279971
96MP0001943_abnormal_respiration0.62752562
97MP0003172_abnormal_lysosome_physiology0.62613431
98MP0003861_abnormal_nervous_system0.62215681
99MP0002876_abnormal_thyroid_physiology0.60571887
100MP0004043_abnormal_pH_regulation0.59872848
101MP0010234_abnormal_vibrissa_follicle0.59544082
102MP0005253_abnormal_eye_physiology0.59239310
103MP0010769_abnormal_survival0.56942211
104MP0010770_preweaning_lethality0.56494834
105MP0002082_postnatal_lethality0.56494834
106MP0003045_fibrosis0.56453305
107MP0010768_mortality/aging0.56011272
108MP0005167_abnormal_blood-brain_barrier0.55826683
109MP0004147_increased_porphyrin_level0.54449212
110MP0000639_abnormal_adrenal_gland0.54161447
111MP0001944_abnormal_pancreas_morphology0.53703015
112MP0003956_abnormal_body_size0.49051886
113MP0001765_abnormal_ion_homeostasis0.48224567

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05064074
2Myokymia (HP:0002411)5.88482930
3Focal seizures (HP:0007359)5.51766563
4Visual hallucinations (HP:0002367)5.32630260
5Epileptic encephalopathy (HP:0200134)4.30234635
6Atonic seizures (HP:0010819)4.28188240
7Absence seizures (HP:0002121)4.16863213
8Progressive cerebellar ataxia (HP:0002073)4.15987386
9Febrile seizures (HP:0002373)4.12872791
10Generalized tonic-clonic seizures (HP:0002069)3.83382345
11Supranuclear gaze palsy (HP:0000605)3.76159465
12Dialeptic seizures (HP:0011146)3.74261971
13Action tremor (HP:0002345)3.66271039
14Ankle clonus (HP:0011448)3.62811178
15Papilledema (HP:0001085)3.41649091
16Mutism (HP:0002300)3.39189668
17Depression (HP:0000716)3.37025116
18Broad-based gait (HP:0002136)3.26934986
19Abnormal eating behavior (HP:0100738)3.11536577
20Poor eye contact (HP:0000817)3.11279748
21Impaired vibration sensation in the lower limbs (HP:0002166)3.11124642
22Dysdiadochokinesis (HP:0002075)3.11122921
23Truncal ataxia (HP:0002078)3.08603618
24Urinary bladder sphincter dysfunction (HP:0002839)3.07388616
25Postural instability (HP:0002172)3.05953583
26Anxiety (HP:0000739)2.99641396
27Impaired social interactions (HP:0000735)2.95440803
28Abnormal social behavior (HP:0012433)2.95440803
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.92731600
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.92731600
31Progressive inability to walk (HP:0002505)2.91683822
32Obstructive sleep apnea (HP:0002870)2.91616830
33Gaze-evoked nystagmus (HP:0000640)2.91225766
34Excessive salivation (HP:0003781)2.86600253
35Drooling (HP:0002307)2.86600253
36Genetic anticipation (HP:0003743)2.83654990
37Dysmetria (HP:0001310)2.77567121
38Abnormality of the lower motor neuron (HP:0002366)2.75304062
39Agitation (HP:0000713)2.74265238
40Urinary urgency (HP:0000012)2.73309294
41Limb dystonia (HP:0002451)2.71063645
42Hemiparesis (HP:0001269)2.68503656
43Spastic gait (HP:0002064)2.58340954
44Hyperventilation (HP:0002883)2.56133947
45Amblyopia (HP:0000646)2.54750197
46Polyphagia (HP:0002591)2.54202960
47Sleep apnea (HP:0010535)2.53815117
48Pheochromocytoma (HP:0002666)2.53497194
49Hemiplegia (HP:0002301)2.53481955
50Bradykinesia (HP:0002067)2.50993643
51Impaired smooth pursuit (HP:0007772)2.50231286
52Torticollis (HP:0000473)2.48680529
53Abnormality of the corticospinal tract (HP:0002492)2.43922787
54Epileptiform EEG discharges (HP:0011182)2.43652061
55Amyotrophic lateral sclerosis (HP:0007354)2.42646048
56Insidious onset (HP:0003587)2.41712711
57Termporal pattern (HP:0011008)2.41712711
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41498018
59EEG with generalized epileptiform discharges (HP:0011198)2.41365662
60Neurofibrillary tangles (HP:0002185)2.39160457
61Cerebral inclusion bodies (HP:0100314)2.38900033
62Intention tremor (HP:0002080)2.36522840
63Scanning speech (HP:0002168)2.36071248
64Abnormality of binocular vision (HP:0011514)2.35170093
65Diplopia (HP:0000651)2.35170093
66Morphological abnormality of the pyramidal tract (HP:0002062)2.35055645
67Ventricular fibrillation (HP:0001663)2.33067308
68Hypsarrhythmia (HP:0002521)2.28994672
69Abnormality of ocular smooth pursuit (HP:0000617)2.28757609
70Increased circulating renin level (HP:0000848)2.28551971
71Prolonged QT interval (HP:0001657)2.27640932
72Annular pancreas (HP:0001734)2.27236240
73Lower limb muscle weakness (HP:0007340)2.26847883
74Tetraplegia (HP:0002445)2.26087989
75Focal dystonia (HP:0004373)2.22797080
76Insomnia (HP:0100785)2.19333725
77Failure to thrive in infancy (HP:0001531)2.17074361
78Neuroendocrine neoplasm (HP:0100634)2.15810254
79Megalencephaly (HP:0001355)2.15599246
80Status epilepticus (HP:0002133)2.14663754
81Fetal akinesia sequence (HP:0001989)2.14646589
82Delusions (HP:0000746)2.11047531
83Stereotypic behavior (HP:0000733)2.09756793
84Cerebral hypomyelination (HP:0006808)2.09621233
85Absent speech (HP:0001344)2.08436753
86Dysmetric saccades (HP:0000641)2.07930557
87Gait imbalance (HP:0002141)2.03633720
88Hypoventilation (HP:0002791)2.02575033
89Craniofacial dystonia (HP:0012179)2.02312183
90Pointed chin (HP:0000307)2.01040284
91Clonus (HP:0002169)2.00389394
92Neuronal loss in central nervous system (HP:0002529)1.98199096
93Inability to walk (HP:0002540)1.95680738
94Psychosis (HP:0000709)1.95167288
95Generalized myoclonic seizures (HP:0002123)1.94932451
96Neoplasm of the heart (HP:0100544)1.94554299
97Peripheral hypomyelination (HP:0007182)1.92842124
98Blue irides (HP:0000635)1.91894483
99Impaired vibratory sensation (HP:0002495)1.90209225
100Inappropriate behavior (HP:0000719)1.90195854
101Abnormality of saccadic eye movements (HP:0000570)1.89358281
102Syncope (HP:0001279)1.86032095
103Macroorchidism (HP:0000053)1.85728198
104Abnormality of salivation (HP:0100755)1.84268765
105Abnormal EKG (HP:0003115)1.84197492
106Gait ataxia (HP:0002066)1.82509875
107Paraplegia (HP:0010550)1.82342644
108Specific learning disability (HP:0001328)1.80860768
109Choreoathetosis (HP:0001266)1.80351082
110Incomplete penetrance (HP:0003829)1.79207516
111Spastic tetraplegia (HP:0002510)1.77536205
112Postural tremor (HP:0002174)1.77226705
113Akinesia (HP:0002304)1.77130892
114Protruding tongue (HP:0010808)1.76952604
115Resting tremor (HP:0002322)1.76892188
116Rigidity (HP:0002063)1.75376566
117Neoplasm of the peripheral nervous system (HP:0100007)1.73740437
118Rapidly progressive (HP:0003678)1.73454457
119Menstrual irregularities (HP:0000858)1.73082920
120Muscular hypotonia of the trunk (HP:0008936)1.70917032
121Bundle branch block (HP:0011710)1.70695288
122Apathy (HP:0000741)1.69519609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.68497059
2MAP3K94.04238229
3MARK13.93242065
4MAP3K43.36513842
5EPHA43.20770212
6MINK12.83472687
7MAP2K72.61526605
8NTRK22.54918461
9MAP3K122.19108913
10PAK62.16715175
11MAP2K42.11640774
12DAPK22.00309991
13PRKD31.86733872
14NTRK11.85925075
15KSR21.84204605
16PNCK1.72880070
17CAMKK11.68488550
18TNIK1.60507208
19KSR11.57485837
20FRK1.54227318
21CDK51.53136045
22MAPK131.50532746
23CASK1.46735513
24SIK21.45713495
25STK381.40151692
26UHMK11.37523212
27GRK51.30113021
28RIPK41.27270975
29PHKG21.26691753
30PHKG11.26691753
31PLK21.24755652
32TYRO31.19218215
33LATS21.18293101
34PRKCG1.18248228
35DAPK11.16758583
36FES1.14199699
37MAP3K21.13971351
38CDK191.08031890
39CAMKK21.01891094
40PRKCH0.99033909
41ARAF0.95267217
42SGK4940.94809574
43SGK2230.94809574
44MAP3K130.93913782
45CAMK2A0.93074506
46WNK30.91665477
47PAK30.91618291
48RET0.89158408
49PRPF4B0.88365416
50SCYL20.88100837
51CDK180.87274169
52STK110.85426072
53ALK0.85195269
54CDK150.85170457
55LMTK20.84900006
56CDK140.84575793
57SGK20.84455014
58CSNK1G20.84260073
59CAMK1G0.82976640
60AKT30.78959476
61CAMK10.77410992
62TAOK10.77068293
63DYRK1A0.75831514
64MAPK120.75059561
65SGK30.74661553
66TNK20.74545542
67CDK11A0.73298884
68CAMK2B0.69423947
69CDC42BPA0.68222904
70SGK10.68084552
71MARK20.66802916
72PINK10.65740891
73WNK10.61142071
74MAP3K10.59582151
75ERBB30.56691789
76FER0.55368662
77RPS6KA30.55189469
78PKN10.54015548
79FGFR30.53251147
80FGFR20.52456630
81PRKCZ0.52254451
82MAPK100.51821283
83OXSR10.51304836
84NEK10.50922842
85RAF10.50515564
86RIPK10.47726463
87PRKCE0.47267467
88CAMK2D0.46395527
89FYN0.44580494
90ROCK20.44578788
91PDK10.44537636
92EPHA30.44060448
93RPS6KA20.43335172
94NLK0.41959794
95CAMK2G0.39952865
96PDPK10.39468580
97PRKG10.38916986
98BCR0.37798798
99CAMK40.35575662
100PRKCB0.34824384
101NEK60.34642468
102BRSK10.34379812
103PRKAA10.34000136
104JAK10.33431023
105PTK2B0.32765675
106PRKACA0.32182687
107CSNK1D0.31572486
108SIK30.30569310
109CSNK1G30.30473551
110CSNK1E0.29831568
111ERBB20.29691372
112BMPR20.29626053
113ICK0.29414101
114MAPK80.29210325
115PRKCA0.27727370
116MAP2K60.27691397

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86359325
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36384215
3GABAergic synapse_Homo sapiens_hsa047272.99219008
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64417620
5Circadian entrainment_Homo sapiens_hsa047132.61757657
6Olfactory transduction_Homo sapiens_hsa047402.60452001
7Morphine addiction_Homo sapiens_hsa050322.54547905
8Glutamatergic synapse_Homo sapiens_hsa047242.46882831
9Long-term potentiation_Homo sapiens_hsa047202.45833285
10Amphetamine addiction_Homo sapiens_hsa050312.33884109
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33605861
12Dopaminergic synapse_Homo sapiens_hsa047282.18764971
13Insulin secretion_Homo sapiens_hsa049112.10603817
14Salivary secretion_Homo sapiens_hsa049702.02867358
15Cholinergic synapse_Homo sapiens_hsa047251.86293551
16Taste transduction_Homo sapiens_hsa047421.85484245
17Cocaine addiction_Homo sapiens_hsa050301.83474660
18Gastric acid secretion_Homo sapiens_hsa049711.82242915
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79189519
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76459540
21Serotonergic synapse_Homo sapiens_hsa047261.69882913
22Renin secretion_Homo sapiens_hsa049241.69263387
23Long-term depression_Homo sapiens_hsa047301.66110495
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63580091
25Oxytocin signaling pathway_Homo sapiens_hsa049211.53290247
26Calcium signaling pathway_Homo sapiens_hsa040201.45264420
27GnRH signaling pathway_Homo sapiens_hsa049121.42447824
28Collecting duct acid secretion_Homo sapiens_hsa049661.39787069
29Gap junction_Homo sapiens_hsa045401.38444193
30Type II diabetes mellitus_Homo sapiens_hsa049301.35128613
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27367724
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26938838
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24850878
34cAMP signaling pathway_Homo sapiens_hsa040241.23514479
35Estrogen signaling pathway_Homo sapiens_hsa049151.23098426
36Axon guidance_Homo sapiens_hsa043601.11950937
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09518928
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07657897
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06045529
40Melanogenesis_Homo sapiens_hsa049161.02329265
41Glioma_Homo sapiens_hsa052141.01546666
42Vibrio cholerae infection_Homo sapiens_hsa051101.01459062
43ErbB signaling pathway_Homo sapiens_hsa040120.99836759
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95594893
45Vitamin B6 metabolism_Homo sapiens_hsa007500.95023626
46Cardiac muscle contraction_Homo sapiens_hsa042600.93314151
47Oocyte meiosis_Homo sapiens_hsa041140.93183815
48Dorso-ventral axis formation_Homo sapiens_hsa043200.90643317
49Nitrogen metabolism_Homo sapiens_hsa009100.89502039
50Phototransduction_Homo sapiens_hsa047440.89485631
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.85422563
52Thyroid hormone synthesis_Homo sapiens_hsa049180.84937570
53Pancreatic secretion_Homo sapiens_hsa049720.83655996
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.80903668
55Type I diabetes mellitus_Homo sapiens_hsa049400.80350353
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76587826
57Dilated cardiomyopathy_Homo sapiens_hsa054140.75864857
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72170922
59MAPK signaling pathway_Homo sapiens_hsa040100.71023228
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.67695897
61Choline metabolism in cancer_Homo sapiens_hsa052310.67253127
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66994631
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.64638855
64Alcoholism_Homo sapiens_hsa050340.63088815
65Glucagon signaling pathway_Homo sapiens_hsa049220.60565108
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59764346
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59583142
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59252678
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58708743
70mTOR signaling pathway_Homo sapiens_hsa041500.58420528
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57575889
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55279810
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54759992
74Ras signaling pathway_Homo sapiens_hsa040140.54201674
75Circadian rhythm_Homo sapiens_hsa047100.53212128
76Endometrial cancer_Homo sapiens_hsa052130.52518636
77Bile secretion_Homo sapiens_hsa049760.50776865
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50587045
79Regulation of autophagy_Homo sapiens_hsa041400.50026352
80Inositol phosphate metabolism_Homo sapiens_hsa005620.49963389
81Prion diseases_Homo sapiens_hsa050200.49702990
82VEGF signaling pathway_Homo sapiens_hsa043700.49273041
83Insulin signaling pathway_Homo sapiens_hsa049100.48710362
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47246953
85Rap1 signaling pathway_Homo sapiens_hsa040150.47117027
86Endocytosis_Homo sapiens_hsa041440.47059194
87Ovarian steroidogenesis_Homo sapiens_hsa049130.46672182
88Renal cell carcinoma_Homo sapiens_hsa052110.46244087
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46215346
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46011519
91Wnt signaling pathway_Homo sapiens_hsa043100.45669475
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45298633
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.44747748
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40626484
95Ether lipid metabolism_Homo sapiens_hsa005650.38365867
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38208190
97Non-small cell lung cancer_Homo sapiens_hsa052230.35619195
98Colorectal cancer_Homo sapiens_hsa052100.34392900
99Mineral absorption_Homo sapiens_hsa049780.31770767
100ABC transporters_Homo sapiens_hsa020100.31688135
101AMPK signaling pathway_Homo sapiens_hsa041520.31025122
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30703793
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30132667
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30115325
105Hedgehog signaling pathway_Homo sapiens_hsa043400.28765059
106Butanoate metabolism_Homo sapiens_hsa006500.28605574
107Chemokine signaling pathway_Homo sapiens_hsa040620.28330936
108Prolactin signaling pathway_Homo sapiens_hsa049170.26852272
109beta-Alanine metabolism_Homo sapiens_hsa004100.24849931
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.23776911
111Tight junction_Homo sapiens_hsa045300.23680302

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