GPRASP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82105012
2vocalization behavior (GO:0071625)5.34717993
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32504726
4neuron cell-cell adhesion (GO:0007158)5.19265774
5synaptic vesicle exocytosis (GO:0016079)5.12831885
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.87513917
7synaptic vesicle maturation (GO:0016188)4.85598868
8locomotory exploration behavior (GO:0035641)4.83727464
9pyrimidine nucleobase catabolic process (GO:0006208)4.82697874
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.69411289
11regulation of glutamate receptor signaling pathway (GO:1900449)4.68593351
12regulation of synaptic vesicle exocytosis (GO:2000300)4.67951344
13protein localization to synapse (GO:0035418)4.63165089
14neurotransmitter secretion (GO:0007269)4.58150893
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.44007918
16glutamate secretion (GO:0014047)4.40133844
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34380823
18regulation of synaptic vesicle transport (GO:1902803)4.15385502
19neuron recognition (GO:0008038)4.12810929
20exploration behavior (GO:0035640)4.09875049
21nucleobase catabolic process (GO:0046113)4.09251836
22layer formation in cerebral cortex (GO:0021819)4.06258467
23positive regulation of synaptic transmission, GABAergic (GO:0032230)4.05165165
24neuronal action potential propagation (GO:0019227)4.00165612
25neurotransmitter transport (GO:0006836)4.00030145
26proline transport (GO:0015824)3.97973874
27glutamate receptor signaling pathway (GO:0007215)3.96756890
28gamma-aminobutyric acid transport (GO:0015812)3.92188352
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.88931974
30transmission of nerve impulse (GO:0019226)3.86478914
31neuromuscular process controlling posture (GO:0050884)3.81999571
32synaptic transmission, glutamatergic (GO:0035249)3.81577048
33neuron-neuron synaptic transmission (GO:0007270)3.79153123
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.74375249
35regulation of neuronal synaptic plasticity (GO:0048168)3.73349140
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71655600
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71167428
38dendritic spine morphogenesis (GO:0060997)3.66608511
39regulation of neurotransmitter levels (GO:0001505)3.65574125
40axonal fasciculation (GO:0007413)3.62160216
41activation of protein kinase A activity (GO:0034199)3.61258325
42long-term memory (GO:0007616)3.60698934
43response to histamine (GO:0034776)3.58982345
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57170799
45mating behavior (GO:0007617)3.56630571
46neurotransmitter-gated ion channel clustering (GO:0072578)3.44912595
47positive regulation of synapse assembly (GO:0051965)3.42615202
48postsynaptic membrane organization (GO:0001941)3.39880869
49regulation of synapse structural plasticity (GO:0051823)3.38814669
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37627335
51cerebellar Purkinje cell differentiation (GO:0021702)3.36079231
52regulation of vesicle fusion (GO:0031338)3.34394718
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33946441
54regulation of glutamate secretion (GO:0014048)3.33609020
55regulation of postsynaptic membrane potential (GO:0060078)3.31494436
56synaptic vesicle endocytosis (GO:0048488)3.31314568
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27488754
58cellular potassium ion homeostasis (GO:0030007)3.27463363
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25267569
60presynaptic membrane assembly (GO:0097105)3.25043464
61positive regulation of membrane potential (GO:0045838)3.24697796
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23437048
63establishment of mitochondrion localization (GO:0051654)3.23402868
64synapse assembly (GO:0007416)3.20492970
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.19791060
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.18475593
67regulation of protein kinase A signaling (GO:0010738)3.18091764
68membrane hyperpolarization (GO:0060081)3.17822793
69social behavior (GO:0035176)3.13517160
70intraspecies interaction between organisms (GO:0051703)3.13517160
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11480359
72regulation of synaptic transmission, GABAergic (GO:0032228)3.10706050
73vesicle transport along microtubule (GO:0047496)3.09707649
74regulation of neurotransmitter secretion (GO:0046928)3.09210049
75membrane depolarization during action potential (GO:0086010)3.08731324
76presynaptic membrane organization (GO:0097090)3.07012803
77prepulse inhibition (GO:0060134)3.06965563
78response to auditory stimulus (GO:0010996)3.02565913
79long-term synaptic potentiation (GO:0060291)3.01036076
80neurotransmitter catabolic process (GO:0042135)3.00658204
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00553702
82membrane depolarization (GO:0051899)2.99851745
83neuronal ion channel clustering (GO:0045161)2.99649775
84sodium ion export (GO:0071436)2.98056212
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.97446253
86cell migration in hindbrain (GO:0021535)2.97352374
87behavioral defense response (GO:0002209)2.96572835
88behavioral fear response (GO:0001662)2.96572835
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96513328
90startle response (GO:0001964)2.96485844
91synaptic transmission (GO:0007268)2.95888875
92positive regulation of synapse maturation (GO:0090129)2.94839801
93auditory behavior (GO:0031223)2.94296867
94female mating behavior (GO:0060180)2.93700519
95regulation of neurotransmitter transport (GO:0051588)2.93624881
96striatum development (GO:0021756)2.93416350
97response to pheromone (GO:0019236)2.93072316
98dendrite morphogenesis (GO:0048813)2.92736895
99synapse organization (GO:0050808)2.92164254
100mechanosensory behavior (GO:0007638)2.91372179
101regulation of female receptivity (GO:0045924)2.91310263
102regulation of synaptic plasticity (GO:0048167)2.90679843
103dendritic spine organization (GO:0097061)2.89374103
104learning (GO:0007612)2.87951714
105regulation of cAMP-dependent protein kinase activity (GO:2000479)2.86054318
106regulation of dendritic spine morphogenesis (GO:0061001)2.86022946
107innervation (GO:0060384)2.85475894
108glycine transport (GO:0015816)2.85274869
109fear response (GO:0042596)2.84949015
110regulation of respiratory system process (GO:0044065)2.84855450
111positive regulation of dendritic spine development (GO:0060999)2.84466162
112neuromuscular synaptic transmission (GO:0007274)2.81580287
113retinal ganglion cell axon guidance (GO:0031290)2.75492655
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74951880
115positive regulation of mitochondrial fission (GO:0090141)2.71505656
116cell communication by electrical coupling (GO:0010644)2.69203556
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67748010
118mitochondrion transport along microtubule (GO:0047497)2.67748010
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66313756
120cerebral cortex radially oriented cell migration (GO:0021799)2.65769379
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64986860
122synaptic vesicle transport (GO:0048489)2.63896105
123establishment of synaptic vesicle localization (GO:0097480)2.63896105
124neurofilament cytoskeleton organization (GO:0060052)2.63423993
125cerebellar granule cell differentiation (GO:0021707)2.61161723
126protein localization to cilium (GO:0061512)2.59673939
127adult walking behavior (GO:0007628)2.57910461
128regulation of synapse assembly (GO:0051963)2.57440975
129establishment of vesicle localization (GO:0051650)2.54530911
130central nervous system projection neuron axonogenesis (GO:0021952)2.53921894
131acidic amino acid transport (GO:0015800)2.53507950
132axon extension (GO:0048675)2.52198289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41784384
2GBX2_23144817_ChIP-Seq_PC3_Human3.57577228
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06131568
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00051576
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95529737
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78113449
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59682020
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.57885682
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57311292
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54917107
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54470091
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54470091
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51694905
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51515342
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46148940
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43059048
17TAF15_26573619_Chip-Seq_HEK293_Human2.41626013
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40677580
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.34003804
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33094790
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.25372805
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19734968
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18433286
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18138497
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.16907790
26DROSHA_22980978_ChIP-Seq_HELA_Human2.15683362
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.11028846
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.04421483
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98209098
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97426860
31AR_21572438_ChIP-Seq_LNCaP_Human1.87435318
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80425483
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76060616
34IGF1R_20145208_ChIP-Seq_DFB_Human1.75299536
35SMAD4_21799915_ChIP-Seq_A2780_Human1.74941032
36ZNF274_21170338_ChIP-Seq_K562_Hela1.74020103
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70825349
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.60540427
39P300_19829295_ChIP-Seq_ESCs_Human1.57960691
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51260144
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49459619
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46742343
43* RNF2_27304074_Chip-Seq_NSC_Mouse1.46394801
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43989620
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43403048
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.42211600
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39235903
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36383549
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35997988
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35857174
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.34386301
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33575433
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31835471
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.31709150
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.30841049
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30543894
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30178768
58AR_25329375_ChIP-Seq_VCAP_Human1.29307901
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.26541741
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25228655
61FUS_26573619_Chip-Seq_HEK293_Human1.25182804
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22711601
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22645187
64STAT3_23295773_ChIP-Seq_U87_Human1.21782021
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21238904
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17577236
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15538577
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14531600
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14227964
70AR_19668381_ChIP-Seq_PC3_Human1.12741905
71ER_23166858_ChIP-Seq_MCF-7_Human1.12150553
72SOX9_26525672_Chip-Seq_HEART_Mouse1.11730388
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11709555
74EWS_26573619_Chip-Seq_HEK293_Human1.10864319
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10227096
76TCF4_23295773_ChIP-Seq_U87_Human1.09884689
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09873333
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09847931
79RUNX2_22187159_ChIP-Seq_PCA_Human1.08701791
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08517973
81VDR_22108803_ChIP-Seq_LS180_Human1.07066922
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06440082
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05031793
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04638928
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.04118701
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03685160
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03538940
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02551137
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02248923
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99907305
91RING1B_27294783_Chip-Seq_NPCs_Mouse0.98345867
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98308420
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.97426089
94JUN_21703547_ChIP-Seq_K562_Human0.97332360
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96968329
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96711685
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96269030
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.95824632
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94911638
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94070957
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93937315
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92107215
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91989800
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91460203
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.90837055
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.90251625
107KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90243100
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90049888
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89793936
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.89674539
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88345033
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88266936
113AHR_22903824_ChIP-Seq_MCF-7_Human0.88169728
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84709821
115CBP_20019798_ChIP-Seq_JUKART_Human0.84709821
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84554086
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83752218
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83752218
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83583696
120BCAT_22108803_ChIP-Seq_LS180_Human0.82732148
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.82180848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.02641849
2MP0004859_abnormal_synaptic_plasticity4.90155900
3MP0003635_abnormal_synaptic_transmissio3.76281172
4MP0009745_abnormal_behavioral_response3.24764725
5MP0009046_muscle_twitch3.20929689
6MP0002064_seizures3.10254961
7MP0005423_abnormal_somatic_nervous3.01854232
8MP0003122_maternal_imprinting3.00890410
9MP0001968_abnormal_touch/_nociception2.99204490
10MP0002063_abnormal_learning/memory/cond2.96062713
11MP0006276_abnormal_autonomic_nervous2.95802320
12MP0004270_analgesia2.93533083
13MP0002572_abnormal_emotion/affect_behav2.74506720
14MP0002272_abnormal_nervous_system2.54752676
15MP0005645_abnormal_hypothalamus_physiol2.52705685
16MP0002734_abnormal_mechanical_nocicepti2.49862496
17MP0001501_abnormal_sleep_pattern2.47333842
18MP0001440_abnormal_grooming_behavior2.40345368
19MP0001486_abnormal_startle_reflex2.34019913
20MP0002736_abnormal_nociception_after2.31111915
21MP0002735_abnormal_chemical_nociception2.17507322
22MP0002733_abnormal_thermal_nociception2.09338504
23MP0001529_abnormal_vocalization2.05394249
24MP0002067_abnormal_sensory_capabilities2.05023287
25MP0001970_abnormal_pain_threshold1.97557831
26MP0002822_catalepsy1.92513586
27MP0005646_abnormal_pituitary_gland1.91394580
28MP0002184_abnormal_innervation1.89798198
29MP0002557_abnormal_social/conspecific_i1.84042614
30MP0005386_behavior/neurological_phenoty1.81847838
31MP0004924_abnormal_behavior1.81847838
32MP0000778_abnormal_nervous_system1.78340509
33MP0003787_abnormal_imprinting1.77918134
34MP0004142_abnormal_muscle_tone1.71441633
35MP0002909_abnormal_adrenal_gland1.64831297
36MP0001984_abnormal_olfaction1.63380417
37MP0001905_abnormal_dopamine_level1.58801301
38MP0009780_abnormal_chondrocyte_physiolo1.58630953
39MP0008569_lethality_at_weaning1.53539588
40MP0004811_abnormal_neuron_physiology1.48203291
41MP0000955_abnormal_spinal_cord1.48173280
42MP0002102_abnormal_ear_morphology1.45154769
43MP0003329_amyloid_beta_deposits1.43870034
44MP0001502_abnormal_circadian_rhythm1.40025676
45MP0003121_genomic_imprinting1.39979819
46MP0002882_abnormal_neuron_morphology1.38518613
47MP0002066_abnormal_motor_capabilities/c1.38072282
48MP0004858_abnormal_nervous_system1.28679973
49MP0003123_paternal_imprinting1.28470741
50MP0003879_abnormal_hair_cell1.26192336
51MP0000751_myopathy1.23695989
52MP0000013_abnormal_adipose_tissue1.20940923
53MP0001188_hyperpigmentation1.20197927
54MP0006072_abnormal_retinal_apoptosis1.18273047
55MP0004885_abnormal_endolymph1.14314829
56MP0005187_abnormal_penis_morphology1.14243805
57MP0000631_abnormal_neuroendocrine_gland1.14235974
58MP0005551_abnormal_eye_electrophysiolog1.13143255
59MP0002638_abnormal_pupillary_reflex1.11260855
60MP0010386_abnormal_urinary_bladder1.10433295
61MP0002837_dystrophic_cardiac_calcinosis1.09090948
62MP0002152_abnormal_brain_morphology1.07725296
63MP0004145_abnormal_muscle_electrophysio1.05755091
64MP0003633_abnormal_nervous_system1.04432607
65MP0004742_abnormal_vestibular_system1.03797915
66MP0002229_neurodegeneration1.01362246
67MP0008872_abnormal_physiological_respon0.98371770
68MP0003283_abnormal_digestive_organ0.98019369
69MP0002876_abnormal_thyroid_physiology0.96997523
70MP0002069_abnormal_eating/drinking_beha0.95634143
71MP0008789_abnormal_olfactory_epithelium0.92385934
72MP0005499_abnormal_olfactory_system0.90442822
73MP0005394_taste/olfaction_phenotype0.90442822
74MP0005535_abnormal_body_temperature0.90061539
75MP0003631_nervous_system_phenotype0.89619883
76MP0003011_delayed_dark_adaptation0.86556534
77MP0003119_abnormal_digestive_system0.84969035
78MP0003634_abnormal_glial_cell0.84629057
79MP0002234_abnormal_pharynx_morphology0.84294799
80MP0002752_abnormal_somatic_nervous0.83810394
81MP0000566_synostosis0.83575898
82MP0005379_endocrine/exocrine_gland_phen0.82934079
83MP0001963_abnormal_hearing_physiology0.82736009
84MP0004085_abnormal_heartbeat0.81977963
85MP0003690_abnormal_glial_cell0.80028691
86MP0003938_abnormal_ear_development0.79801324
87MP0004133_heterotaxia0.78159110
88MP0006292_abnormal_olfactory_placode0.74186557
89MP0008961_abnormal_basal_metabolism0.73405158
90MP0005253_abnormal_eye_physiology0.73263165
91MP0008877_abnormal_DNA_methylation0.70993584
92MP0000569_abnormal_digit_pigmentation0.70431502
93MP0002090_abnormal_vision0.70215395
94MP0000049_abnormal_middle_ear0.70195995
95MP0008995_early_reproductive_senescence0.69222365
96MP0001664_abnormal_digestion0.69076997
97MP0001177_atelectasis0.68680704
98MP0005248_abnormal_Harderian_gland0.67781289
99MP0002653_abnormal_ependyma_morphology0.66678632
100MP0002233_abnormal_nose_morphology0.66216736
101MP0008874_decreased_physiological_sensi0.66084899
102MP0003632_abnormal_nervous_system0.65521324
103MP0001943_abnormal_respiration0.65261929
104MP0000639_abnormal_adrenal_gland0.65067758
105MP0003942_abnormal_urinary_system0.65018486
106MP0003137_abnormal_impulse_conducting0.64861644
107MP0001299_abnormal_eye_distance/0.63403089
108MP0003183_abnormal_peptide_metabolism0.61766658
109MP0002082_postnatal_lethality0.61401375
110MP0005409_darkened_coat_color0.61272780
111MP0004215_abnormal_myocardial_fiber0.60849011
112MP0005623_abnormal_meninges_morphology0.58685495
113MP0002163_abnormal_gland_morphology0.56407972
114MP0002751_abnormal_autonomic_nervous0.55761166
115MP0000026_abnormal_inner_ear0.55526916
116MP0001485_abnormal_pinna_reflex0.54928611
117MP0003861_abnormal_nervous_system0.53958762
118MP0010770_preweaning_lethality0.53126138

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.72527190
2Myokymia (HP:0002411)5.45873982
3Focal seizures (HP:0007359)5.27116097
4Visual hallucinations (HP:0002367)5.06982578
5Atonic seizures (HP:0010819)4.91783685
6Absence seizures (HP:0002121)4.36876773
7Febrile seizures (HP:0002373)4.32594314
8Progressive cerebellar ataxia (HP:0002073)4.21091819
9Epileptic encephalopathy (HP:0200134)4.16955357
10Generalized tonic-clonic seizures (HP:0002069)3.92663789
11Dialeptic seizures (HP:0011146)3.88246612
12Limb dystonia (HP:0002451)3.54070932
13Polyphagia (HP:0002591)3.34763209
14Abnormal eating behavior (HP:0100738)3.32964786
15Supranuclear gaze palsy (HP:0000605)3.26137890
16Broad-based gait (HP:0002136)3.17010930
17Ankle clonus (HP:0011448)3.13109577
18Progressive inability to walk (HP:0002505)3.10260075
19Anxiety (HP:0000739)3.06652266
20Failure to thrive in infancy (HP:0001531)3.04754621
21Depression (HP:0000716)2.98518785
22Pheochromocytoma (HP:0002666)2.92784732
23Mutism (HP:0002300)2.91564558
24Truncal ataxia (HP:0002078)2.91473767
25Action tremor (HP:0002345)2.89063499
26Impaired vibration sensation in the lower limbs (HP:0002166)2.80757354
27Agitation (HP:0000713)2.77863360
28Dysdiadochokinesis (HP:0002075)2.71478855
29Neuroendocrine neoplasm (HP:0100634)2.64538102
30Excessive salivation (HP:0003781)2.62306559
31Drooling (HP:0002307)2.62306559
32Gaze-evoked nystagmus (HP:0000640)2.61426921
33Dysmetria (HP:0001310)2.58175368
34Urinary bladder sphincter dysfunction (HP:0002839)2.55966410
35Papilledema (HP:0001085)2.55120252
36Abnormal hair whorl (HP:0010721)2.55085498
37Hyperventilation (HP:0002883)2.54283063
38Gait imbalance (HP:0002141)2.53680617
39Hemiparesis (HP:0001269)2.53646642
40Poor eye contact (HP:0000817)2.52304203
41Hypoventilation (HP:0002791)2.52101980
42Amblyopia (HP:0000646)2.51990967
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46907011
44Postural instability (HP:0002172)2.40772483
45Abnormal ciliary motility (HP:0012262)2.36774216
46Impaired social interactions (HP:0000735)2.36702346
47Abnormal social behavior (HP:0012433)2.36702346
48Epileptiform EEG discharges (HP:0011182)2.36356109
49EEG with generalized epileptiform discharges (HP:0011198)2.34052935
50Spastic gait (HP:0002064)2.31444080
51Diplopia (HP:0000651)2.29138764
52Abnormality of binocular vision (HP:0011514)2.29138764
53Urinary urgency (HP:0000012)2.28122417
54Genetic anticipation (HP:0003743)2.27685764
55Cortical dysplasia (HP:0002539)2.26891453
56Neurofibrillary tangles (HP:0002185)2.26276546
57Spastic tetraplegia (HP:0002510)2.24836942
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24689539
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.24689539
60Psychosis (HP:0000709)2.23238713
61Bradykinesia (HP:0002067)2.23196984
62Hypsarrhythmia (HP:0002521)2.20587268
63Specific learning disability (HP:0001328)2.20462428
64Poor suck (HP:0002033)2.19552438
65Abnormality of the corticospinal tract (HP:0002492)2.19323902
66Cerebral inclusion bodies (HP:0100314)2.18098400
67Abnormality of the lower motor neuron (HP:0002366)2.13847566
68Intention tremor (HP:0002080)2.13386627
69Amyotrophic lateral sclerosis (HP:0007354)2.13158912
70Congenital primary aphakia (HP:0007707)2.11655495
71Insidious onset (HP:0003587)2.11351513
72Termporal pattern (HP:0011008)2.11351513
73Fetal akinesia sequence (HP:0001989)2.10711046
74Scanning speech (HP:0002168)2.09869954
75Hyperthyroidism (HP:0000836)2.09441580
76Retinal dysplasia (HP:0007973)2.08911745
77Wrist flexion contracture (HP:0001239)2.06623582
78Impaired smooth pursuit (HP:0007772)2.06537688
79Esotropia (HP:0000565)2.05801474
80Medial flaring of the eyebrow (HP:0010747)2.05194951
81Lissencephaly (HP:0001339)2.04369948
82Cerebral hypomyelination (HP:0006808)2.03428275
83Abnormality of the labia minora (HP:0012880)2.02725560
84Narrow nasal bridge (HP:0000446)2.01974873
85Torticollis (HP:0000473)2.01763883
86Blue irides (HP:0000635)2.01206453
87Abnormal respiratory motile cilium physiology (HP:0012261)2.00938059
88Hepatoblastoma (HP:0002884)2.00554793
89Absent/shortened dynein arms (HP:0200106)1.98994687
90Dynein arm defect of respiratory motile cilia (HP:0012255)1.98994687
91Lower limb muscle weakness (HP:0007340)1.98698807
92Status epilepticus (HP:0002133)1.98673830
93Hemiplegia (HP:0002301)1.98408408
94Inability to walk (HP:0002540)1.97913683
95Hypoplasia of the brainstem (HP:0002365)1.96434827
96Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96434827
97Nephrogenic diabetes insipidus (HP:0009806)1.96149496
98Generalized myoclonic seizures (HP:0002123)1.95650050
99Acute necrotizing encephalopathy (HP:0006965)1.94455429
100Neuronal loss in central nervous system (HP:0002529)1.94384740
101Focal dystonia (HP:0004373)1.94278045
102Postural tremor (HP:0002174)1.93417737
103Absent speech (HP:0001344)1.90881739
104Abnormality of ocular smooth pursuit (HP:0000617)1.90655902
105Progressive macrocephaly (HP:0004481)1.89929830
106Sleep apnea (HP:0010535)1.89597592
107Abnormal respiratory epithelium morphology (HP:0012253)1.89056633
108Abnormal respiratory motile cilium morphology (HP:0005938)1.89056633
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.89038706
110Poor coordination (HP:0002370)1.88915258
111Genital tract atresia (HP:0001827)1.88094626
112Abnormal sex determination (HP:0012244)1.87219229
113Sex reversal (HP:0012245)1.87219229
114Oligomenorrhea (HP:0000876)1.85177576
115Vaginal atresia (HP:0000148)1.84888427
116Oligodactyly (hands) (HP:0001180)1.81939729
117Muscular hypotonia of the trunk (HP:0008936)1.81575287
118Incomplete penetrance (HP:0003829)1.80316587
119Postaxial hand polydactyly (HP:0001162)1.75397885
120Pachygyria (HP:0001302)1.73712790
121Craniofacial dystonia (HP:0012179)1.72829738
122Hypoplasia of the corpus callosum (HP:0002079)1.68597526
123Akinesia (HP:0002304)1.66671872
124Short foot (HP:0001773)1.66213396
125Morphological abnormality of the pyramidal tract (HP:0002062)1.66093054
126Decreased testicular size (HP:0008734)1.64678081
127Tubulointerstitial nephritis (HP:0001970)1.63058472
128Optic nerve hypoplasia (HP:0000609)1.61955448
129Broad foot (HP:0001769)1.61330684
130Left ventricular hypertrophy (HP:0001712)1.59578907
131CNS hypomyelination (HP:0003429)1.57223440
132Hypothermia (HP:0002045)1.55850910
133Astrocytoma (HP:0009592)1.55434952
134Abnormality of the astrocytes (HP:0100707)1.55434952
135Aplasia/Hypoplasia of the lens (HP:0008063)1.55164406
136Cutaneous finger syndactyly (HP:0010554)1.55159270
137Type II lissencephaly (HP:0007260)1.54427568
138Labial hypoplasia (HP:0000066)1.51523667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.64062031
2MAP3K93.64454260
3MARK13.54058290
4MAP3K43.35186577
5MAP3K123.21704714
6MAP2K72.80768177
7PNCK2.72021919
8MINK12.65773386
9NTRK22.64200024
10EPHA42.57909428
11CASK2.42787881
12MAP2K42.20750633
13TNIK2.07787933
14TRIM281.81954423
15MAPK131.79050128
16PAK61.73729095
17NTRK11.72562950
18DYRK21.71130158
19UHMK11.55368392
20ARAF1.54638735
21KSR21.54348681
22GRK51.53136248
23CDK51.44040102
24DAPK21.43349905
25MAP4K21.42084019
26SIK21.35807976
27CSNK1G11.34448922
28PLK21.30384460
29KSR11.29669586
30CDK191.28098269
31FES1.24922100
32CSNK1A1L1.23618153
33PRKCG1.23033087
34PHKG11.20345143
35PHKG21.20345143
36WNK31.17111494
37CAMKK11.15316682
38CAMK2A1.12714809
39EPHA31.10065224
40MAP3K131.09617452
41PRKD31.09560893
42DAPK11.01944973
43LATS21.00226122
44CSNK1G20.99577855
45PAK30.99382875
46STK380.98372493
47TNK20.95264639
48RIPK40.94560164
49FGFR20.90271581
50CAMK2B0.89253836
51SGK4940.87390145
52SGK2230.87390145
53ADRBK20.87356806
54TYRO30.87327353
55CAMKK20.85221974
56OXSR10.84713962
57PRPF4B0.84365343
58CDK140.84221377
59CDK180.84005877
60MAP3K20.83626124
61GRK70.83049810
62CDK150.81937113
63NME10.75218716
64STK110.73287562
65PRKCH0.72154303
66DYRK1A0.71857610
67CAMK10.71264358
68CDK11A0.70038679
69CAMK1G0.69583599
70SGK20.69070831
71RET0.67444651
72CSNK1G30.67079429
73CAMK2D0.66781134
74LMTK20.65220592
75CDC42BPA0.63682816
76BCKDK0.62846891
77FER0.62629545
78EPHB20.62468018
79SGK10.60417730
80PRKCE0.59808911
81CAMK2G0.59302065
82CSNK1A10.58253382
83AKT30.58053443
84BCR0.57997374
85ADRBK10.57117590
86PKN10.56091518
87CCNB10.52713089
88MAP3K10.52245327
89MARK20.51650659
90SCYL20.50362601
91RPS6KA30.49422247
92TSSK60.48965383
93STK160.48364074
94WNK10.48290014
95SRPK10.48181007
96CSNK1D0.47438296
97ERBB30.46776073
98MAPKAPK50.46406899
99ALK0.46228469
100MAPK100.45734069
101RPS6KA20.44698956
102BRSK10.44587777
103PRKCZ0.44564114
104PLK30.44073034
105DYRK1B0.43982261
106PRKAA10.43860518
107PINK10.43772953
108SGK30.42987256
109CAMK40.42942746
110LIMK10.42805965
111FGR0.42782806
112ROCK20.41257454
113BRAF0.41009592
114MUSK0.40826705
115PRKG10.40173701
116PRKACA0.39701653
117WNK40.39257154
118RAF10.38003649
119NEK60.37881825
120TESK10.37608181
121FYN0.37604069
122CSNK1E0.37537181
123PRKACB0.36292374
124PRKDC0.33093549
125STK38L0.32412185

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.39367840
2Synaptic vesicle cycle_Homo sapiens_hsa047213.53571902
3GABAergic synapse_Homo sapiens_hsa047273.11351698
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82613796
5Morphine addiction_Homo sapiens_hsa050322.61213217
6Circadian entrainment_Homo sapiens_hsa047132.50428855
7Olfactory transduction_Homo sapiens_hsa047402.49687406
8Glutamatergic synapse_Homo sapiens_hsa047242.40533454
9Amphetamine addiction_Homo sapiens_hsa050312.38720784
10Long-term potentiation_Homo sapiens_hsa047202.32812589
11Dopaminergic synapse_Homo sapiens_hsa047282.15118976
12Taste transduction_Homo sapiens_hsa047422.12110667
13Collecting duct acid secretion_Homo sapiens_hsa049662.09485221
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07369824
15Insulin secretion_Homo sapiens_hsa049112.01028687
16Cocaine addiction_Homo sapiens_hsa050301.98966322
17Serotonergic synapse_Homo sapiens_hsa047261.96593902
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90162058
19Salivary secretion_Homo sapiens_hsa049701.89862358
20Long-term depression_Homo sapiens_hsa047301.77600876
21Oxidative phosphorylation_Homo sapiens_hsa001901.74215813
22Renin secretion_Homo sapiens_hsa049241.74068761
23Cholinergic synapse_Homo sapiens_hsa047251.73439709
24Gastric acid secretion_Homo sapiens_hsa049711.71550847
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58193611
26Cardiac muscle contraction_Homo sapiens_hsa042601.55503757
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47926967
28Calcium signaling pathway_Homo sapiens_hsa040201.46588678
29Oxytocin signaling pathway_Homo sapiens_hsa049211.45905069
30Vibrio cholerae infection_Homo sapiens_hsa051101.45371910
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44382090
32Parkinsons disease_Homo sapiens_hsa050121.43608796
33GnRH signaling pathway_Homo sapiens_hsa049121.30156962
34Alzheimers disease_Homo sapiens_hsa050101.30042762
35Gap junction_Homo sapiens_hsa045401.29234750
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21088166
37Estrogen signaling pathway_Homo sapiens_hsa049151.14566881
38cAMP signaling pathway_Homo sapiens_hsa040241.09805934
39Type II diabetes mellitus_Homo sapiens_hsa049301.08879375
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07567458
41Axon guidance_Homo sapiens_hsa043601.06038978
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01515486
43Huntingtons disease_Homo sapiens_hsa050160.97883713
44Phototransduction_Homo sapiens_hsa047440.97403630
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97304301
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94269913
47Melanogenesis_Homo sapiens_hsa049160.93145037
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92597771
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91037287
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90259047
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.88098881
52Steroid biosynthesis_Homo sapiens_hsa001000.87807695
53Vitamin B6 metabolism_Homo sapiens_hsa007500.86554933
54Type I diabetes mellitus_Homo sapiens_hsa049400.86401820
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85229334
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.83956626
57ErbB signaling pathway_Homo sapiens_hsa040120.83848784
58Dorso-ventral axis formation_Homo sapiens_hsa043200.83166605
59Hippo signaling pathway_Homo sapiens_hsa043900.81591675
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81261504
61Oocyte meiosis_Homo sapiens_hsa041140.80004235
62Thyroid hormone synthesis_Homo sapiens_hsa049180.76894357
63Pancreatic secretion_Homo sapiens_hsa049720.74622085
64Glioma_Homo sapiens_hsa052140.73684980
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69804378
66Dilated cardiomyopathy_Homo sapiens_hsa054140.69304563
67Protein export_Homo sapiens_hsa030600.68324641
68Regulation of autophagy_Homo sapiens_hsa041400.67227170
69Alcoholism_Homo sapiens_hsa050340.66527482
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66359163
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64847925
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.63413241
73MAPK signaling pathway_Homo sapiens_hsa040100.62592937
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60705208
75Tight junction_Homo sapiens_hsa045300.60228967
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59921902
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59666034
78Prion diseases_Homo sapiens_hsa050200.58798779
79Propanoate metabolism_Homo sapiens_hsa006400.57166164
80AMPK signaling pathway_Homo sapiens_hsa041520.53404880
81beta-Alanine metabolism_Homo sapiens_hsa004100.52431615
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52335490
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51693442
84Basal cell carcinoma_Homo sapiens_hsa052170.51379323
85Glucagon signaling pathway_Homo sapiens_hsa049220.51082302
86Arginine and proline metabolism_Homo sapiens_hsa003300.50724938
87Choline metabolism in cancer_Homo sapiens_hsa052310.50501575
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48223134
89Fatty acid elongation_Homo sapiens_hsa000620.46611014
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46430477
91Ovarian steroidogenesis_Homo sapiens_hsa049130.46410011
92Fatty acid metabolism_Homo sapiens_hsa012120.46151245
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45957340
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45915123
95Peroxisome_Homo sapiens_hsa041460.45754080
96Ras signaling pathway_Homo sapiens_hsa040140.44409556
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43864192
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43670234
99Rheumatoid arthritis_Homo sapiens_hsa053230.43538421
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42621550
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41775065
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40616866
103Butanoate metabolism_Homo sapiens_hsa006500.40594770
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.39876441
105Inositol phosphate metabolism_Homo sapiens_hsa005620.39527541
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39115655
107Renal cell carcinoma_Homo sapiens_hsa052110.38984217
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38888846
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38470651
110Wnt signaling pathway_Homo sapiens_hsa043100.36741342
111Circadian rhythm_Homo sapiens_hsa047100.36196938
112Insulin signaling pathway_Homo sapiens_hsa049100.35889983
113mRNA surveillance pathway_Homo sapiens_hsa030150.33639763
114Bile secretion_Homo sapiens_hsa049760.32554944
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31129242
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.29318591
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28322007
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.28309266
119Hedgehog signaling pathway_Homo sapiens_hsa043400.28177763
120Rap1 signaling pathway_Homo sapiens_hsa040150.27887743
121Phagosome_Homo sapiens_hsa041450.26184414
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26118941
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25837685
124Endocytosis_Homo sapiens_hsa041440.23753123
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23671358
126Endometrial cancer_Homo sapiens_hsa052130.23143070

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