GPRC5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.60460751
2establishment of apical/basal cell polarity (GO:0035089)7.21550871
3embryonic process involved in female pregnancy (GO:0060136)7.14141312
4surfactant homeostasis (GO:0043129)6.49600457
5desmosome organization (GO:0002934)6.40470647
6transcription from mitochondrial promoter (GO:0006390)6.35359633
7proline metabolic process (GO:0006560)6.19186140
8establishment of monopolar cell polarity (GO:0061162)6.16019231
9establishment or maintenance of monopolar cell polarity (GO:0061339)6.16019231
10regulation of integrin activation (GO:0033623)5.91072912
11positive regulation of protein homooligomerization (GO:0032464)5.87915471
12skin morphogenesis (GO:0043589)5.58798103
13replication fork processing (GO:0031297)5.41399032
14regulation of protein homooligomerization (GO:0032462)5.05383864
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00038097
16chemical homeostasis within a tissue (GO:0048875)4.85199514
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.81087907
18regulation of glomerular filtration (GO:0003093)4.71628270
19embryonic placenta development (GO:0001892)4.70314038
20protein autoprocessing (GO:0016540)4.68706859
21cell adhesion mediated by integrin (GO:0033627)4.67432184
22oxidative demethylation (GO:0070989)4.60779867
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.42476788
24regulation of hippo signaling (GO:0035330)4.34028988
25cellular response to ATP (GO:0071318)4.30337348
26regulation of water loss via skin (GO:0033561)4.26921369
27negative regulation of JAK-STAT cascade (GO:0046426)4.24036566
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.19510244
29COPI coating of Golgi vesicle (GO:0048205)4.18837158
30Golgi transport vesicle coating (GO:0048200)4.18837158
31trophectodermal cell differentiation (GO:0001829)4.16010642
32regulation of integrin-mediated signaling pathway (GO:2001044)4.15725250
33membrane raft organization (GO:0031579)4.11150425
34regulation of podosome assembly (GO:0071801)4.08195608
35hypotonic response (GO:0006971)4.07555780
36regulation of transforming growth factor beta2 production (GO:0032909)4.06943226
37embryonic camera-type eye development (GO:0031076)4.03207734
38mitotic G1 DNA damage checkpoint (GO:0031571)4.00897211
39negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.93472155
40renal system process involved in regulation of blood volume (GO:0001977)3.93033952
41DNA deamination (GO:0045006)3.92944046
42negative regulation of Ras GTPase activity (GO:0034261)3.84966356
43lung vasculature development (GO:0060426)3.84556490
44protein localization to endosome (GO:0036010)3.83901943
45mitochondrial DNA metabolic process (GO:0032042)3.83894666
46diterpenoid biosynthetic process (GO:0016102)3.82109812
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.76125551
48multicellular organismal water homeostasis (GO:0050891)3.71149671
49intestinal epithelial cell development (GO:0060576)3.68254845
50formation of translation preinitiation complex (GO:0001731)3.65318925
51apoptotic process involved in morphogenesis (GO:0060561)3.61744348
52positive regulation of protein oligomerization (GO:0032461)3.61102167
53amyloid precursor protein metabolic process (GO:0042982)3.60562539
54poly(A)+ mRNA export from nucleus (GO:0016973)3.59842005
55proteasome assembly (GO:0043248)3.58568074
56negative regulation of chondrocyte differentiation (GO:0032331)3.57443189
57mitotic G1/S transition checkpoint (GO:0044819)3.55615764
58labyrinthine layer development (GO:0060711)3.55163042
59activation of Rac GTPase activity (GO:0032863)3.52447311
60DNA strand renaturation (GO:0000733)3.51475313
61regulation of translational fidelity (GO:0006450)3.50787181
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.48363706
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.48363706
64G1 DNA damage checkpoint (GO:0044783)3.47012793
65tight junction assembly (GO:0070830)3.45649293
66negative regulation of keratinocyte proliferation (GO:0010839)3.44731109
67cell-substrate junction assembly (GO:0007044)3.44722314
68branching involved in salivary gland morphogenesis (GO:0060445)3.42923667
69hepatocyte differentiation (GO:0070365)3.42036825
70negative regulation of complement activation (GO:0045916)3.37616590
71mRNA cleavage (GO:0006379)3.35691473
72positive regulation of epidermal cell differentiation (GO:0045606)3.34164617
73face development (GO:0060324)3.33220725
74hepatocyte apoptotic process (GO:0097284)3.32478338
75negative regulation of cell cycle arrest (GO:0071157)3.32461472
76negative regulation of fatty acid biosynthetic process (GO:0045717)3.32284180
77polarized epithelial cell differentiation (GO:0030859)3.28723301
78DNA integration (GO:0015074)3.28427626
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.28042563
80establishment of skin barrier (GO:0061436)3.25545569
81mesodermal cell differentiation (GO:0048333)3.24503317
82negative regulation of protein oligomerization (GO:0032460)3.23717640
83keratinocyte proliferation (GO:0043616)3.23475769
84regulation of protein oligomerization (GO:0032459)3.22295197
85positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.22293117
86epithelial cell-cell adhesion (GO:0090136)3.20831837
87water homeostasis (GO:0030104)3.18782535
88negative regulation of cartilage development (GO:0061037)3.17056322
89hemidesmosome assembly (GO:0031581)3.14008224
90response to xenobiotic stimulus (GO:0009410)3.13589138
91regulation of apoptotic process involved in morphogenesis (GO:1902337)3.13557810
92cell-substrate adherens junction assembly (GO:0007045)3.12806350
93focal adhesion assembly (GO:0048041)3.12806350
94nodal signaling pathway (GO:0038092)3.11842830
95glutamine family amino acid biosynthetic process (GO:0009084)3.11120017
96sphingosine metabolic process (GO:0006670)3.10779960
97L-ascorbic acid metabolic process (GO:0019852)3.10622800
98membrane budding (GO:0006900)3.09978330
99positive regulation of keratinocyte differentiation (GO:0045618)3.09163377
100positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.07297234
101columnar/cuboidal epithelial cell development (GO:0002066)3.06312680
102glial cell migration (GO:0008347)3.05788679
103establishment or maintenance of bipolar cell polarity (GO:0061245)3.04350591
104establishment or maintenance of apical/basal cell polarity (GO:0035088)3.04350591
105regulation of mitochondrial depolarization (GO:0051900)3.03449254
106endothelial cell morphogenesis (GO:0001886)3.02795868
107cellular response to zinc ion (GO:0071294)3.01552534
108negative regulation of adherens junction organization (GO:1903392)3.00108170
109negative regulation of focal adhesion assembly (GO:0051895)3.00108170
110negative regulation of cell junction assembly (GO:1901889)3.00108170
111protein heterotetramerization (GO:0051290)2.99976624
112anatomical structure regression (GO:0060033)2.99470088
113protein targeting to vacuole (GO:0006623)2.99019346
114protein targeting to lysosome (GO:0006622)2.99019346
115establishment of protein localization to vacuole (GO:0072666)2.99019346
116regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.98279131
117auditory receptor cell stereocilium organization (GO:0060088)2.96494838
118sulfur amino acid catabolic process (GO:0000098)2.94813478
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.94742725
120mammary gland epithelial cell proliferation (GO:0033598)2.94552866
121embryonic eye morphogenesis (GO:0048048)2.94331306
122viral mRNA export from host cell nucleus (GO:0046784)2.93652985
123anterior/posterior axis specification, embryo (GO:0008595)2.93103042
124regulation of sister chromatid cohesion (GO:0007063)2.93053803
125regulation of posttranscriptional gene silencing (GO:0060147)2.92598973
126regulation of gene silencing by miRNA (GO:0060964)2.92598973
127regulation of gene silencing by RNA (GO:0060966)2.92598973
128hippo signaling (GO:0035329)2.91382860
129ER overload response (GO:0006983)2.90735268
130renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.88718183
131atrioventricular valve morphogenesis (GO:0003181)2.88227769
132keratinocyte development (GO:0003334)2.87983881
133negative regulation of protein activation cascade (GO:2000258)2.87840263
134prostanoid biosynthetic process (GO:0046457)2.87616264
135prostaglandin biosynthetic process (GO:0001516)2.87616264
136terpenoid biosynthetic process (GO:0016114)2.87214303
137calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.86118222
138UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85715044
139negative regulation of stress fiber assembly (GO:0051497)2.85330880
140signal complex assembly (GO:0007172)2.83885442
141renal filtration (GO:0097205)2.83808814
142nucleobase-containing small molecule interconversion (GO:0015949)2.82891125
143convergent extension (GO:0060026)2.82760593
144regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.81513943
145regulation of tight junction assembly (GO:2000810)2.80608552
146positive regulation of cell junction assembly (GO:1901890)2.79234435
147positive regulation of focal adhesion assembly (GO:0051894)2.79234435
148endothelial cell chemotaxis (GO:0035767)2.79170541
149positive regulation of adherens junction organization (GO:1903393)2.78370967
150sphingomyelin metabolic process (GO:0006684)2.78256963
151regulation of cellular amino acid metabolic process (GO:0006521)2.77768023
152adherens junction assembly (GO:0034333)2.76389888
153regulation of response to reactive oxygen species (GO:1901031)2.74685009
154positive regulation of epidermis development (GO:0045684)2.74614155
155nucleotide-sugar biosynthetic process (GO:0009226)2.74375716
156norepinephrine metabolic process (GO:0042415)2.74091798
157regulation of early endosome to late endosome transport (GO:2000641)2.72338523
158positive regulation of developmental pigmentation (GO:0048087)2.70393610
159diol metabolic process (GO:0034311)2.70353115
160cell-cell junction assembly (GO:0007043)2.69965930
161positive regulation of circadian rhythm (GO:0042753)2.69924626
162sulfate transmembrane transport (GO:1902358)2.69446922
163spliceosomal tri-snRNP complex assembly (GO:0000244)2.68886679
164organ formation (GO:0048645)2.68199991
165positive regulation by host of viral transcription (GO:0043923)2.67932536
166protein retention in ER lumen (GO:0006621)2.67789857
167cell differentiation involved in embryonic placenta development (GO:0060706)2.65401107
168negative regulation of protein tyrosine kinase activity (GO:0061099)2.63596100
169regulation of keratinocyte differentiation (GO:0045616)2.63562805
170cytoskeletal anchoring at plasma membrane (GO:0007016)2.63084912
171GDP-mannose metabolic process (GO:0019673)2.62546791
172regulation of mitotic spindle organization (GO:0060236)2.60889799
173regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.56530151
174establishment of protein localization to plasma membrane (GO:0090002)2.54028585
175negative regulation of transcription by competitive promoter binding (GO:0010944)2.53787230
176positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.52287411
177negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.51884938
178mitotic nuclear envelope reassembly (GO:0007084)2.51649070
179nuclear envelope reassembly (GO:0031468)2.51649070
180protein hydroxylation (GO:0018126)2.51335390
181branching involved in mammary gland duct morphogenesis (GO:0060444)2.51096845
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50209783
183regulation of phospholipase A2 activity (GO:0032429)2.49806385
184sphingoid metabolic process (GO:0046519)2.48052749
185fibroblast migration (GO:0010761)2.46391947
186regulation of cardioblast differentiation (GO:0051890)2.45202129
187mammary gland development (GO:0030879)2.44789479
188pyrimidine nucleoside salvage (GO:0043097)2.42321604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.48450555
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.50270950
3NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.26046395
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.10661796
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.10661796
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.10661796
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.03245449
8* SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.01153047
9* SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.01153047
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.93730982
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.81222638
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78917795
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.59985462
14* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.57352293
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.55725531
16* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.38595003
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.36608923
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33176560
19AR_21909140_ChIP-Seq_LNCAP_Human2.29579526
20* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.11150579
21RACK7_27058665_Chip-Seq_MCF-7_Human2.09370561
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08400280
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.08313395
24* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.96327956
25LXR_22292898_ChIP-Seq_THP-1_Human1.95394365
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94122541
27ZNF263_19887448_ChIP-Seq_K562_Human1.91559929
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90133917
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89991110
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88056211
31* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86926061
32POU5F1_16518401_ChIP-PET_MESCs_Mouse1.83422311
33* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.83174773
34VDR_21846776_ChIP-Seq_THP-1_Human1.82021463
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78881174
36* GATA4_25053715_ChIP-Seq_YYC3_Human1.78613121
37* SOX2_20726797_ChIP-Seq_SW620_Human1.76587250
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75673645
39E2F7_22180533_ChIP-Seq_HELA_Human1.74409604
40* CDX2_20551321_ChIP-Seq_CACO-2_Human1.71984350
41* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71470482
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.69498086
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67835598
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67061809
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.66315805
46* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66063281
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.65982170
48KLF5_25053715_ChIP-Seq_YYC3_Human1.65036098
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63741168
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.60956594
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60096419
52* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.58220072
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55318568
54* ESR2_21235772_ChIP-Seq_MCF-7_Human1.55167087
55* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53590117
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52032493
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51623872
58EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.51035446
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50512212
60AHR_22903824_ChIP-Seq_MCF-7_Human1.49606003
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.49566394
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49182907
63CJUN_26792858_Chip-Seq_BT549_Human1.48616193
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48585242
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47304197
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.47188475
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46646107
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.44549947
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44190369
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.43919992
71SOX2_18692474_ChIP-Seq_MEFs_Mouse1.43413126
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.43294344
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41598537
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.41222955
75* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40557211
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40443230
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39314864
78ATF3_27146783_Chip-Seq_COLON_Human1.36857381
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35167581
80* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.34886444
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.34821680
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33773122
83* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.33122895
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32995293
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32436940
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30718633
87* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28885802
88NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28692482
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26920587
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26239478
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24653003
92* GATA2_21666600_ChIP-Seq_HMVEC_Human1.22318731
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22001721
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21958929
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.21404900
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21210742
97* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21162623
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20552308
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20190542
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19992892
101KDM2B_26808549_Chip-Seq_DND41_Human1.19319672
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.18257522
103* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17433812
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17179479
105KDM2B_26808549_Chip-Seq_K562_Human1.16169230
106TET1_21451524_ChIP-Seq_MESCs_Mouse1.15932104
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12532003
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12058883
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.11920624
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11420185
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11189628
112GATA6_25053715_ChIP-Seq_YYC3_Human1.10779593
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10283701
114ELF5_23300383_ChIP-Seq_T47D_Human1.10111718
115* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09617555
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08698871
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08479916
118NANOG_16518401_ChIP-PET_MESCs_Mouse1.05172451
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04002039
120BRD4_25478319_ChIP-Seq_HGPS_Human1.03600575
121CHD1_26751641_Chip-Seq_LNCaP_Human1.03468841
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03353603
123SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03095356
124CLOCK_20551151_ChIP-Seq_293T_Human1.02144402
125CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02079133
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01821663
127SMC4_20622854_ChIP-Seq_HELA_Human0.99866434
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99166595
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99107361
130MYC_22102868_ChIP-Seq_BL_Human0.98621464
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98495515
132CREB1_26743006_Chip-Seq_LNCaP_Human0.97630235
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97432782
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.97288977
135* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97286509
136* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97180258
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97065008
138KAP1_27257070_Chip-Seq_ESCs_Mouse0.96288426
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96141341
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95936087
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.95226374
142CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95164605
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94048344
144* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93839106
145DCP1A_22483619_ChIP-Seq_HELA_Human0.92237755
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.92143590
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90445556
148RXR_22158963_ChIP-Seq_LIVER_Mouse0.89172177
149PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89042815
150ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86286047
151TP53_22127205_ChIP-Seq_IMR90_Human0.86204714
152TP63_22573176_ChIP-Seq_HFKS_Human0.86122820
153EOMES_21245162_ChIP-Seq_HESCs_Human0.86111974
154ELK1_22589737_ChIP-Seq_MCF10A_Human0.85419121
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.84262318
156* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83467681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence3.88730069
2MP0010030_abnormal_orbit_morphology3.50317130
3MP0004782_abnormal_surfactant_physiolog3.43255876
4MP0008057_abnormal_DNA_replication3.36776407
5MP0009278_abnormal_bone_marrow3.02987801
6MP0005171_absent_coat_pigmentation2.60897722
7MP0001958_emphysema2.49422553
8MP0010352_gastrointestinal_tract_polyps2.49031857
9MP0003283_abnormal_digestive_organ2.37332149
10MP0003890_abnormal_embryonic-extraembry2.26215405
11MP0010678_abnormal_skin_adnexa2.20769012
12MP0004233_abnormal_muscle_weight2.18887695
13MP0003119_abnormal_digestive_system2.15352532
14MP0003786_premature_aging2.14917468
15MP0003453_abnormal_keratinocyte_physiol2.11490065
16MP0003566_abnormal_cell_adhesion2.10832111
17MP0002282_abnormal_trachea_morphology2.07133881
18MP0009780_abnormal_chondrocyte_physiolo1.98238069
19MP0004264_abnormal_extraembryonic_tissu1.92436971
20MP0003806_abnormal_nucleotide_metabolis1.88361646
21MP0000462_abnormal_digestive_system1.85873068
22MP0003705_abnormal_hypodermis_morpholog1.85482269
23MP0005397_hematopoietic_system_phenotyp1.84835422
24MP0001545_abnormal_hematopoietic_system1.84835422
25MP0001216_abnormal_epidermal_layer1.83492405
26MP0002796_impaired_skin_barrier1.79963908
27MP0005076_abnormal_cell_differentiation1.73313370
28MP0008004_abnormal_stomach_pH1.71401275
29MP0000678_abnormal_parathyroid_gland1.71294606
30MP0008875_abnormal_xenobiotic_pharmacok1.68501960
31MP0002009_preneoplasia1.64559307
32MP0009697_abnormal_copulation1.64474145
33MP0000627_abnormal_mammary_gland1.64363823
34MP0002086_abnormal_extraembryonic_tissu1.63759565
35MP0004133_heterotaxia1.63704375
36MP0000383_abnormal_hair_follicle1.60388739
37MP0005023_abnormal_wound_healing1.60147446
38MP0008438_abnormal_cutaneous_collagen1.59998031
39MP0000537_abnormal_urethra_morphology1.58578065
40MP0003941_abnormal_skin_development1.52082585
41MP0010234_abnormal_vibrissa_follicle1.48785560
42MP0010771_integument_phenotype1.47466471
43MP0010368_abnormal_lymphatic_system1.43665985
44MP0000490_abnormal_crypts_of1.43131259
45MP0000762_abnormal_tongue_morphology1.42906899
46MP0002653_abnormal_ependyma_morphology1.41689674
47MP0004957_abnormal_blastocyst_morpholog1.39106395
48MP0002084_abnormal_developmental_patter1.34539544
49MP0000470_abnormal_stomach_morphology1.34450764
50MP0005058_abnormal_lysosome_morphology1.34165690
51MP0000516_abnormal_urinary_system1.34107927
52MP0005367_renal/urinary_system_phenotyp1.34107927
53MP0003828_pulmonary_edema1.28629573
54MP0005275_abnormal_skin_tensile1.28426272
55MP0004197_abnormal_fetal_growth/weight/1.28285023
56MP0003045_fibrosis1.28095383
57MP0002132_abnormal_respiratory_system1.27686652
58MP0002085_abnormal_embryonic_tissue1.24319051
59MP0001661_extended_life_span1.24088977
60MP0004858_abnormal_nervous_system1.22556469
61MP0001542_abnormal_bone_strength1.22123387
62MP0005083_abnormal_biliary_tract1.22076157
63MP0002249_abnormal_larynx_morphology1.19408446
64MP0003091_abnormal_cell_migration1.18278765
65MP0001348_abnormal_lacrimal_gland1.17633682
66MP0003115_abnormal_respiratory_system1.17499071
67MP0000003_abnormal_adipose_tissue1.16935420
68MP0004272_abnormal_basement_membrane1.16737455
69MP0001293_anophthalmia1.16395267
70MP0005501_abnormal_skin_physiology1.16344966
71MP0005257_abnormal_intraocular_pressure1.15205017
72MP0003693_abnormal_embryo_hatching1.14753148
73MP0001697_abnormal_embryo_size1.14582309
74MP0005380_embryogenesis_phenotype1.14276279
75MP0001672_abnormal_embryogenesis/_devel1.14276279
76MP0009053_abnormal_anal_canal1.14141550
77MP0005167_abnormal_blood-brain_barrier1.13529912
78MP0002060_abnormal_skin_morphology1.13439761
79MP0000579_abnormal_nail_morphology1.13168683
80MP0000377_abnormal_hair_follicle1.12498840
81MP0004883_abnormal_blood_vessel1.10220638
82MP0002295_abnormal_pulmonary_circulatio1.09232960
83MP0000858_altered_metastatic_potential1.08326574
84MP0001730_embryonic_growth_arrest1.07659518
85MP0003567_abnormal_fetal_cardiomyocyte1.07204158
86MP0000733_abnormal_muscle_development1.07004824
87MP0001873_stomach_inflammation1.06804470
88MP0005388_respiratory_system_phenotype1.06776826
89MP0002133_abnormal_respiratory_system1.06776826
90MP0001881_abnormal_mammary_gland1.05179765
91MP0005451_abnormal_body_composition1.03546254
92MP0006138_congestive_heart_failure1.02805163
93MP0004185_abnormal_adipocyte_glucose1.02747834
94MP0002111_abnormal_tail_morphology0.98746554
95MP0000013_abnormal_adipose_tissue0.98418801
96MP0005508_abnormal_skeleton_morphology0.98354070
97MP0003935_abnormal_craniofacial_develop0.98095952
98MP0003984_embryonic_growth_retardation0.97228374
99MP0000681_abnormal_thyroid_gland0.96342906
100MP0005165_increased_susceptibility_to0.95667529
101MP0001175_abnormal_lung_morphology0.95207511
102MP0005248_abnormal_Harderian_gland0.94978009
103MP0002925_abnormal_cardiovascular_devel0.94796411
104MP0000647_abnormal_sebaceous_gland0.94324034
105MP0002234_abnormal_pharynx_morphology0.94293881
106MP0002932_abnormal_joint_morphology0.94032939
107MP0000350_abnormal_cell_proliferation0.93214759
108MP0003315_abnormal_perineum_morphology0.93211889
109MP0005164_abnormal_response_to0.91981089
110MP0002088_abnormal_embryonic_growth/wei0.91721426
111MP0001879_abnormal_lymphatic_vessel0.89446648
112MP0005085_abnormal_gallbladder_physiolo0.89416008
113MP0000477_abnormal_intestine_morphology0.89201124
114MP0005623_abnormal_meninges_morphology0.87266375
115MP0000432_abnormal_head_morphology0.86389931
116MP0001243_abnormal_dermal_layer0.86102327
117MP0008932_abnormal_embryonic_tissue0.85278199
118MP0003950_abnormal_plasma_membrane0.85107190
119MP0001849_ear_inflammation0.84949509
120MP0003191_abnormal_cellular_cholesterol0.84607356
121MP0002877_abnormal_melanocyte_morpholog0.84203380
122MP0003755_abnormal_palate_morphology0.83265450
123MP0001340_abnormal_eyelid_morphology0.82934690
124MP0000534_abnormal_ureter_morphology0.82370341
125MP0005409_darkened_coat_color0.81985999
126MP0009931_abnormal_skin_appearance0.81486218
127MP0002138_abnormal_hepatobiliary_system0.81268745
128MP0003718_maternal_effect0.80141530
129MP0002080_prenatal_lethality0.79995230
130MP0000427_abnormal_hair_cycle0.78328202
131MP0005330_cardiomyopathy0.77794840
132MP0000639_abnormal_adrenal_gland0.76978390
133MP0005197_abnormal_uvea_morphology0.76811057
134MP0005174_abnormal_tail_pigmentation0.76578991
135MP0002896_abnormal_bone_mineralization0.76337672
136MP0010155_abnormal_intestine_physiology0.74953499
137MP0005621_abnormal_cell_physiology0.74177936
138MP0003077_abnormal_cell_cycle0.74010681
139MP0002098_abnormal_vibrissa_morphology0.72946180
140MP0006072_abnormal_retinal_apoptosis0.72837337
141MP0009840_abnormal_foam_cell0.72825367
142MP0005395_other_phenotype0.72578316
143MP0009643_abnormal_urine_homeostasis0.72309344
144MP0000467_abnormal_esophagus_morphology0.71661258
145MP0001664_abnormal_digestion0.69192843
146MP0000613_abnormal_salivary_gland0.69088702
147MP0004043_abnormal_pH_regulation0.68305778
148MP0000358_abnormal_cell_content/0.68148839
149MP0001191_abnormal_skin_condition0.65771322
150MP0001727_abnormal_embryo_implantation0.65673287
151MP0005670_abnormal_white_adipose0.65379538
152MP0003936_abnormal_reproductive_system0.63560091
153MP0001853_heart_inflammation0.62567906
154MP0004947_skin_inflammation0.62176111

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)5.15603176
2Pustule (HP:0200039)5.02193409
3Interstitial pulmonary disease (HP:0006530)4.68705240
4Alopecia of scalp (HP:0002293)4.57736530
5Annular pancreas (HP:0001734)4.45479560
6Polycythemia (HP:0001901)4.15552571
7Short nail (HP:0001799)4.07779250
8Rib fusion (HP:0000902)4.07173002
9Turricephaly (HP:0000262)4.00213602
10Concave nail (HP:0001598)3.80704620
11Trismus (HP:0000211)3.70447024
12Coronal craniosynostosis (HP:0004440)3.67181939
13Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.57818067
14Vertebral hypoplasia (HP:0008417)3.57818067
15Abnormal hemoglobin (HP:0011902)3.52669827
16Abnormality of the distal phalanges of the toes (HP:0010182)3.50982261
17Short humerus (HP:0005792)3.49742003
18Rectovaginal fistula (HP:0000143)3.44839261
19Rectal fistula (HP:0100590)3.44839261
20Vascular calcification (HP:0004934)3.42443413
21Vaginal fistula (HP:0004320)3.41303179
22Facial hemangioma (HP:0000329)3.39033734
23Bowing of the arm (HP:0006488)3.37083724
24Bowed forearm bones (HP:0003956)3.37083724
25Aplasia/hypoplasia of the humerus (HP:0006507)3.31562548
26Intestinal atresia (HP:0011100)3.31358850
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31218341
28Distal lower limb amyotrophy (HP:0008944)3.30966710
29Hyperactive renin-angiotensin system (HP:0000841)3.26338790
30Distal lower limb muscle weakness (HP:0009053)3.26155835
31Reduced subcutaneous adipose tissue (HP:0003758)3.23046453
32Osteolytic defects of the hand bones (HP:0009699)3.18205558
33Osteolytic defects of the phalanges of the hand (HP:0009771)3.18205558
34Micronodular cirrhosis (HP:0001413)3.17707201
35Tongue fasciculations (HP:0001308)3.16509944
36Hypokinesia (HP:0002375)3.15882372
37Cardiovascular calcification (HP:0011915)3.12930004
38Premature rupture of membranes (HP:0001788)3.07582143
39Increased IgM level (HP:0003496)3.06869531
40Renal salt wasting (HP:0000127)3.05831846
41Cerebral aneurysm (HP:0004944)3.02809752
42Muscle fibrillation (HP:0010546)3.02505053
43Intestinal fistula (HP:0100819)3.00541572
44Poikiloderma (HP:0001029)2.97843926
45Vertebral compression fractures (HP:0002953)2.97470876
46Male infertility (HP:0003251)2.96041513
47Pili torti (HP:0003777)2.95955729
48Growth hormone excess (HP:0000845)2.93009942
49Cervical subluxation (HP:0003308)2.79591405
50Hypochromic microcytic anemia (HP:0004840)2.78774630
51Onycholysis (HP:0001806)2.76860831
52Absent radius (HP:0003974)2.72562283
53Dysautonomia (HP:0002459)2.67917563
54Arterial tortuosity (HP:0005116)2.65503873
55Abnormality of the aortic arch (HP:0012303)2.65077708
56Aplasia involving forearm bones (HP:0009822)2.62849577
57Absent forearm bone (HP:0003953)2.62849577
58Broad face (HP:0000283)2.62211930
59Glomerulosclerosis (HP:0000096)2.62201019
60Joint stiffness (HP:0001387)2.60543562
61Entropion (HP:0000621)2.59665405
62Focal segmental glomerulosclerosis (HP:0000097)2.58414756
63Mitral stenosis (HP:0001718)2.58373619
64Alacrima (HP:0000522)2.54239886
65Premature skin wrinkling (HP:0100678)2.53550147
66Orthostatic hypotension (HP:0001278)2.53053545
67Anteriorly placed anus (HP:0001545)2.50976279
68Aplasia cutis congenita (HP:0001057)2.47752063
69Chronic bronchitis (HP:0004469)2.46910246
70Natal tooth (HP:0000695)2.44142121
71Sparse eyelashes (HP:0000653)2.42734682
72Gastrointestinal atresia (HP:0002589)2.40418609
73Bifid uvula (HP:0000193)2.38345352
74Abdominal distention (HP:0003270)2.37487617
75Lip pit (HP:0100267)2.37479787
76Glucose intolerance (HP:0000833)2.37001814
77Choanal stenosis (HP:0000452)2.36238156
78Rough bone trabeculation (HP:0100670)2.34732087
79Shawl scrotum (HP:0000049)2.33478894
80Vascular tortuosity (HP:0004948)2.32499040
81Urinary glycosaminoglycan excretion (HP:0003541)2.31270511
82Mucopolysacchariduria (HP:0008155)2.31270511
83Hyperacusis (HP:0010780)2.30241397
84Abnormal hair laboratory examination (HP:0003328)2.27468761
85Spinal cord compression (HP:0002176)2.27199671
86Ankyloglossia (HP:0010296)2.26934924
87Milia (HP:0001056)2.26718820
88Hypotension (HP:0002615)2.26650874
89Congenital hip dislocation (HP:0001374)2.26458736
90Increased connective tissue (HP:0009025)2.25285970
91Hypotrichosis (HP:0001006)2.24901257
92Amelogenesis imperfecta (HP:0000705)2.23962198
93Selective tooth agenesis (HP:0001592)2.23832255
94Plantar hyperkeratosis (HP:0007556)2.21775100
95Acanthosis nigricans (HP:0000956)2.21162372
96Diaphragmatic weakness (HP:0009113)2.20740126
97Distal upper limb amyotrophy (HP:0007149)2.19545539
98Upper limb amyotrophy (HP:0009129)2.19545539
99Fragile skin (HP:0001030)2.19244743
100Lower limb amyotrophy (HP:0007210)2.16428714
101Flat acetabular roof (HP:0003180)2.16242214
102Progressive sensorineural hearing impairment (HP:0000408)2.10125782
103Abnormality of glycolipid metabolism (HP:0010969)2.09602499
104Abnormality of liposaccharide metabolism (HP:0010968)2.09602499
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.09602499
106Hypoplasia of the ulna (HP:0003022)2.09393937
107Hyperthyroidism (HP:0000836)2.08511043
108Dysostosis multiplex (HP:0000943)2.08342335
109Aplasia of the musculature (HP:0100854)2.08169523
110Nail dystrophy (HP:0008404)2.08089779
111Hypoplastic ischia (HP:0003175)2.06541185
112Respiratory distress (HP:0002098)2.06506917
113Broad alveolar ridges (HP:0000187)2.06282389
114Conjugated hyperbilirubinemia (HP:0002908)2.05488408
115Patellar aplasia (HP:0006443)2.04612922
116Unilateral renal agenesis (HP:0000122)2.03988247
117Elbow flexion contracture (HP:0002987)2.03223687
118Abnormality of male internal genitalia (HP:0000022)2.01458979
119Fragile nails (HP:0001808)2.00261626
120Hypoplasia of dental enamel (HP:0006297)2.00225861
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99749500
122Abnormality of polysaccharide metabolism (HP:0011012)1.99749500
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99749500
124Cheilitis (HP:0100825)1.98190434
125Abnormality of the gastric mucosa (HP:0004295)1.96158868
126Spinal muscular atrophy (HP:0007269)1.95733728
127Atrophic scars (HP:0001075)1.95256874
128Bilateral sensorineural hearing impairment (HP:0008619)1.95043807
129Mildly elevated creatine phosphokinase (HP:0008180)1.94815874
130Abnormality of oral frenula (HP:0000190)1.94521796
131Esophageal varix (HP:0002040)1.93951603
132Abnormality of the nasal septum (HP:0000419)1.93100921
133Ureteral duplication (HP:0000073)1.92678458
134Metaphyseal cupping (HP:0003021)1.90969263
135Tubulointerstitial fibrosis (HP:0005576)1.90660531
136Vertebral fusion (HP:0002948)1.90635243
137Pterygium (HP:0001059)1.90328777
138Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89753547
139Squamous cell carcinoma (HP:0002860)1.89391086
140Protrusio acetabuli (HP:0003179)1.88731260
141Advanced eruption of teeth (HP:0006288)1.87968603
142Aplasia/Hypoplasia of the patella (HP:0006498)1.86574356
143Aplasia/Hypoplasia of the ulna (HP:0006495)1.85159416
144Redundant skin (HP:0001582)1.84155820
145Congenital ichthyosiform erythroderma (HP:0007431)1.83480016
146Vertebral clefting (HP:0008428)1.83291362
147Short chin (HP:0000331)1.83193392
148Esophageal atresia (HP:0002032)1.82611154
149Absent thumb (HP:0009777)1.82567573
150Upper limb muscle weakness (HP:0003484)1.82542328
151Gastrointestinal dysmotility (HP:0002579)1.82371089
152Gout (HP:0001997)1.81802715
153Abnormality of the fetal cardiovascular system (HP:0010948)1.80841835
154Abnormal umbilical cord blood vessels (HP:0011403)1.80841835
155Single umbilical artery (HP:0001195)1.80841835
156Truncus arteriosus (HP:0001660)1.80789878
157Popliteal pterygium (HP:0009756)1.79570912
158Progressive hearing impairment (HP:0001730)1.76641594
159Aortic aneurysm (HP:0004942)1.74615772
160Esophageal neoplasm (HP:0100751)1.74072184
161Neoplasm of head and neck (HP:0012288)1.74072184
162Deviation of the thumb (HP:0009603)1.73910328
163Split hand (HP:0001171)1.73132999
164Decreased lacrimation (HP:0000633)1.72959776
165Hyperkalemia (HP:0002153)1.72927720
166Abnormality of the labia minora (HP:0012880)1.72625022
167Right ventricular cardiomyopathy (HP:0011663)1.72278799
168Abnormal trabecular bone morphology (HP:0100671)1.70607625
169Facial cleft (HP:0002006)1.69944403
170Axonal loss (HP:0003447)1.69095090
171Abnormality of the acetabulum (HP:0003170)1.65119837
172Sparse lateral eyebrow (HP:0005338)1.64858372
173Fibular aplasia (HP:0002990)1.64422264
174Atelectasis (HP:0100750)1.63926562
175Seborrheic dermatitis (HP:0001051)1.62820240
176Abnormality of chloride homeostasis (HP:0011422)1.62738118
177Bradycardia (HP:0001662)1.60585228
178Achilles tendon contracture (HP:0001771)1.60094773
179Patellar dislocation (HP:0002999)1.59885813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.18312826
2DDR25.06923030
3MAPK154.19369596
4EPHA23.66760301
5MAP3K113.63813550
6MAP3K63.39203199
7MAP3K122.81933426
8MATK2.72427761
9TYRO32.65435319
10PIM22.55779071
11FGR2.37598918
12PBK2.31689511
13PINK12.31031039
14PDGFRA2.21229181
15BMX2.17195841
16CSK2.10876144
17PRKD22.02067709
18DAPK11.91282163
19DYRK1B1.76676504
20NME21.76142642
21MYLK1.72141040
22TRPM71.71548708
23SIK31.69682848
24MAP3K31.63480181
25AKT31.60755198
26LATS21.57088643
27LMTK21.55676062
28NME11.54112366
29IRAK31.52877585
30CDK61.51533326
31TAOK21.49843638
32MAP3K21.41558285
33SIK11.41384604
34UHMK11.39096891
35YES11.38997003
36CDK71.37213607
37EIF2AK11.31822159
38MST41.31098830
39GSK3A1.30309483
40NTRK11.28937000
41BUB11.28693148
42TRIB31.28354194
43EPHB21.26108531
44TAOK11.25956578
45STK101.20484326
46ERBB41.18217483
47RIPK11.16800544
48TGFBR21.14767981
49PAK41.13181691
50FLT31.10834270
51SMG11.09861830
52PIM11.09109245
53STK381.07421086
54TIE11.06866382
55ABL21.06644381
56PTK21.01885238
57SCYL20.99872533
58RPS6KC10.98311882
59RPS6KL10.98311882
60PDGFRB0.94131523
61CDC42BPA0.90745531
62STK390.89756188
63CDK80.88055887
64LATS10.87426802
65RPS6KA60.85132757
66RPS6KB20.84475730
67BRSK10.83041065
68MELK0.80680410
69MAPKAPK30.77926439
70TRIM280.74409657
71MTOR0.74087106
72STK240.73361923
73CDK120.73071332
74LRRK20.72948573
75BRSK20.72698683
76WEE10.72039488
77ERBB30.71360617
78STK30.68341674
79PDK20.67350651
80TESK10.65564755
81MAPK110.62617072
82PHKG20.62123982
83PHKG10.62123982
84WNK40.61066745
85MAP2K20.59560122
86MAP2K30.58867268
87NEK10.58852856
88MET0.57019059
89FER0.56720772
90MAP2K10.56418956
91MAP3K90.55624634
92STK38L0.53324621
93BCR0.52891240
94KSR10.52305630
95PRKG20.52277456
96ILK0.51606447
97PLK10.51432208
98CHEK20.49121402
99RPS6KA10.47842547
100EPHB10.47834758
101DYRK30.47334628
102HIPK20.46341536
103EPHA30.45809860
104ZAP700.45789125
105ERN10.45376375
106PRKCI0.45014174
107TTN0.44297186
108MST1R0.42525659
109MAP3K100.41697273
110CDK90.41507148
111PRKAA10.41306457
112PAK20.38861873
113PRKD10.38776746
114CAMK2D0.37709445
115PRPF4B0.36524288
116* EGFR0.36288915
117TESK20.36261878
118MAP3K80.34325821
119FGFR10.33459789
120AURKB0.31554112
121NEK60.30294062
122CAMK2B0.29979122
123MAPKAPK20.29896465
124LIMK10.29880834
125AURKA0.29617557
126AKT20.29311345
127PAK10.29185012
128INSR0.29039097
129PDPK10.28002208
130MAPK10.27276245
131CAMK2G0.27245817
132PTK60.25199869
133DMPK0.24851621
134MAPK30.23849779
135NEK20.23366316
136MAP3K10.23281287
137ABL10.23037356
138PRKAA20.22470586
139ARAF0.22454615
140CSNK2A10.20796873
141CHUK0.20775681
142EIF2AK20.20606235
143ALK0.20483526
144RAF10.19316953
145CSNK1A1L0.17449766
146FGFR40.16689872
147CDK20.16558555

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.05566817
2Proteasome_Homo sapiens_hsa030504.38159706
3Adherens junction_Homo sapiens_hsa045203.29113597
4Base excision repair_Homo sapiens_hsa034103.02856839
5Hippo signaling pathway_Homo sapiens_hsa043903.01228651
6Mismatch repair_Homo sapiens_hsa034302.93659663
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.65624862
8Bladder cancer_Homo sapiens_hsa052192.62822686
9Tight junction_Homo sapiens_hsa045302.26444123
10Hedgehog signaling pathway_Homo sapiens_hsa043402.17061033
11Sulfur metabolism_Homo sapiens_hsa009202.12318339
12TGF-beta signaling pathway_Homo sapiens_hsa043502.06522414
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00571620
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.90131880
15Notch signaling pathway_Homo sapiens_hsa043301.88916080
16Sphingolipid metabolism_Homo sapiens_hsa006001.86414315
17mTOR signaling pathway_Homo sapiens_hsa041501.83609357
18Mineral absorption_Homo sapiens_hsa049781.83487642
19Phenylalanine metabolism_Homo sapiens_hsa003601.81634246
20Other glycan degradation_Homo sapiens_hsa005111.78977410
21DNA replication_Homo sapiens_hsa030301.77944390
22N-Glycan biosynthesis_Homo sapiens_hsa005101.76888970
23Circadian rhythm_Homo sapiens_hsa047101.72709727
24Shigellosis_Homo sapiens_hsa051311.69399994
25Vibrio cholerae infection_Homo sapiens_hsa051101.67280579
26ECM-receptor interaction_Homo sapiens_hsa045121.66525304
27p53 signaling pathway_Homo sapiens_hsa041151.65287451
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64053763
29Small cell lung cancer_Homo sapiens_hsa052221.60754281
30Basal cell carcinoma_Homo sapiens_hsa052171.59990655
31Arginine and proline metabolism_Homo sapiens_hsa003301.55758386
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51515147
33Focal adhesion_Homo sapiens_hsa045101.49159709
34Pentose phosphate pathway_Homo sapiens_hsa000301.47569586
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40735799
36Proteoglycans in cancer_Homo sapiens_hsa052051.35574442
37VEGF signaling pathway_Homo sapiens_hsa043701.34536124
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.25237221
39Wnt signaling pathway_Homo sapiens_hsa043101.24020588
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23806411
41Pyrimidine metabolism_Homo sapiens_hsa002401.23217803
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22843542
43MicroRNAs in cancer_Homo sapiens_hsa052061.22683421
44RNA transport_Homo sapiens_hsa030131.22504075
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21550366
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20142353
47Thyroid cancer_Homo sapiens_hsa052161.17243956
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14416997
49Fructose and mannose metabolism_Homo sapiens_hsa000511.12813078
50Glutathione metabolism_Homo sapiens_hsa004801.07171031
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06440943
52Nucleotide excision repair_Homo sapiens_hsa034201.03715697
53Tyrosine metabolism_Homo sapiens_hsa003501.03170231
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.01888235
55Chronic myeloid leukemia_Homo sapiens_hsa052201.01514242
56Viral myocarditis_Homo sapiens_hsa054161.00825741
57Sulfur relay system_Homo sapiens_hsa041220.99522615
58Hepatitis C_Homo sapiens_hsa051600.98731798
59Colorectal cancer_Homo sapiens_hsa052100.98305703
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94386466
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93481231
62Renal cell carcinoma_Homo sapiens_hsa052110.93072366
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.90646227
64Folate biosynthesis_Homo sapiens_hsa007900.90004446
65Fatty acid metabolism_Homo sapiens_hsa012120.88355255
66Dorso-ventral axis formation_Homo sapiens_hsa043200.88058866
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88013500
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87462900
69mRNA surveillance pathway_Homo sapiens_hsa030150.86579088
70Cell cycle_Homo sapiens_hsa041100.85962543
71Biosynthesis of amino acids_Homo sapiens_hsa012300.85672873
72Fatty acid elongation_Homo sapiens_hsa000620.84591139
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81035271
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79817364
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78204925
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77695710
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76945154
78Renin-angiotensin system_Homo sapiens_hsa046140.76536620
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75394700
80Pathways in cancer_Homo sapiens_hsa052000.75148028
81Endometrial cancer_Homo sapiens_hsa052130.73736396
82ErbB signaling pathway_Homo sapiens_hsa040120.72155615
83Spliceosome_Homo sapiens_hsa030400.71399797
84Rap1 signaling pathway_Homo sapiens_hsa040150.71300690
85Lysosome_Homo sapiens_hsa041420.69087482
86Gap junction_Homo sapiens_hsa045400.68004955
87Endocytosis_Homo sapiens_hsa041440.67596915
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67355784
89Starch and sucrose metabolism_Homo sapiens_hsa005000.66603767
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.66225836
91Acute myeloid leukemia_Homo sapiens_hsa052210.66008261
92Chemical carcinogenesis_Homo sapiens_hsa052040.64225077
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62403688
94Salmonella infection_Homo sapiens_hsa051320.61269446
95Carbon metabolism_Homo sapiens_hsa012000.59151764
96Pancreatic cancer_Homo sapiens_hsa052120.58799170
97Choline metabolism in cancer_Homo sapiens_hsa052310.58473398
98Dilated cardiomyopathy_Homo sapiens_hsa054140.55667814
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55478581
100Galactose metabolism_Homo sapiens_hsa000520.53102372
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52839500
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52319418
103Amoebiasis_Homo sapiens_hsa051460.52033411
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51925019
105Viral carcinogenesis_Homo sapiens_hsa052030.50915374
106AMPK signaling pathway_Homo sapiens_hsa041520.50013882
107Legionellosis_Homo sapiens_hsa051340.49766459
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.48125472
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.48054176
110Prostate cancer_Homo sapiens_hsa052150.47948128
111Apoptosis_Homo sapiens_hsa042100.47346214
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46987511
113Histidine metabolism_Homo sapiens_hsa003400.45680446
114Lysine degradation_Homo sapiens_hsa003100.45450001
115Insulin resistance_Homo sapiens_hsa049310.45221359
116Oocyte meiosis_Homo sapiens_hsa041140.44649253
117Thyroid hormone synthesis_Homo sapiens_hsa049180.42349703
118Homologous recombination_Homo sapiens_hsa034400.42225020
119Bile secretion_Homo sapiens_hsa049760.41656730
120Vitamin B6 metabolism_Homo sapiens_hsa007500.41327526
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.39954759
122HIF-1 signaling pathway_Homo sapiens_hsa040660.39477093
123Fanconi anemia pathway_Homo sapiens_hsa034600.38773892
124HTLV-I infection_Homo sapiens_hsa051660.38344805
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37554694
126ABC transporters_Homo sapiens_hsa020100.36661987
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36471954
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.36177561
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35368251
130Insulin signaling pathway_Homo sapiens_hsa049100.35059781
131Selenocompound metabolism_Homo sapiens_hsa004500.34842494
132Pyruvate metabolism_Homo sapiens_hsa006200.34623873
133Axon guidance_Homo sapiens_hsa043600.34451845
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33616842
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33584792
136Melanoma_Homo sapiens_hsa052180.30510320
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30201804
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30027812
139Protein digestion and absorption_Homo sapiens_hsa049740.29606490
140MAPK signaling pathway_Homo sapiens_hsa040100.28940484
141Phagosome_Homo sapiens_hsa041450.28583818
142Arginine biosynthesis_Homo sapiens_hsa002200.26832874

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