GPRC5D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone secretion (GO:0030252)9.16437009
2determination of adult lifespan (GO:0008340)8.90420922
3positive regulation of growth hormone secretion (GO:0060124)8.89699674
4positive regulation of Cdc42 GTPase activity (GO:0043089)7.99637404
5keratinization (GO:0031424)7.87200448
6pericardium development (GO:0060039)7.24034333
7intermediate filament organization (GO:0045109)7.15184134
8positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)7.11204407
9tongue development (GO:0043586)7.11115628
10peptide cross-linking (GO:0018149)7.08438084
11activation of Rac GTPase activity (GO:0032863)6.93359329
12adhesion of symbiont to host cell (GO:0044650)6.73164865
13virion attachment to host cell (GO:0019062)6.73164865
14apoptotic cell clearance (GO:0043277)6.42997624
15regulation of growth hormone secretion (GO:0060123)6.32323072
16desmosome organization (GO:0002934)6.23538947
17ventricular cardiac muscle cell development (GO:0055015)6.09864037
18pharyngeal system development (GO:0060037)5.61229929
19adhesion of symbiont to host (GO:0044406)5.57346137
20citrulline biosynthetic process (GO:0019240)5.54373458
21hair follicle morphogenesis (GO:0031069)5.35411372
22positive regulation of immune response to tumor cell (GO:0002839)5.13550232
23regulation of immune response to tumor cell (GO:0002837)5.13550232
24regulation of response to tumor cell (GO:0002834)5.13550232
25positive regulation of response to tumor cell (GO:0002836)5.13550232
26hypothalamus development (GO:0021854)5.13294746
27bundle of His cell to Purkinje myocyte communication (GO:0086069)4.93093119
28T cell migration (GO:0072678)4.92589521
29regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.88759860
30leukocyte tethering or rolling (GO:0050901)4.85152784
31cellular response to ATP (GO:0071318)4.84746218
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.84342097
33embryonic heart tube development (GO:0035050)4.77987496
34nitric oxide biosynthetic process (GO:0006809)4.75882512
35urea metabolic process (GO:0019627)4.74093522
36urea cycle (GO:0000050)4.74093522
37regulation of integrin activation (GO:0033623)4.73753436
38regulation of transforming growth factor beta2 production (GO:0032909)4.67220437
39activated T cell proliferation (GO:0050798)4.64665721
40regulation of Cdc42 GTPase activity (GO:0043088)4.64297127
41alkaloid metabolic process (GO:0009820)4.54226310
42regulation of hair follicle development (GO:0051797)4.35798529
43negative regulation of interleukin-10 production (GO:0032693)4.31872814
44nitrogen cycle metabolic process (GO:0071941)4.30141727
45multicellular organismal water homeostasis (GO:0050891)4.28841967
46positive regulation of granulocyte chemotaxis (GO:0071624)4.26128214
47fatty acid elongation (GO:0030497)4.23911269
48Golgi transport vesicle coating (GO:0048200)4.09771765
49COPI coating of Golgi vesicle (GO:0048205)4.09771765
50activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.98059902
51positive regulation of cell adhesion mediated by integrin (GO:0033630)3.96590358
52epidermis development (GO:0008544)3.93074911
53water homeostasis (GO:0030104)3.91810720
54intermediate filament cytoskeleton organization (GO:0045104)3.89128829
55positive regulation of receptor biosynthetic process (GO:0010870)3.84681220
56positive regulation of nuclease activity (GO:0032075)3.84448917
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.82932202
58ER overload response (GO:0006983)3.82594508
59positive regulation of monocyte chemotaxis (GO:0090026)3.79007058
60intermediate filament-based process (GO:0045103)3.78783928
61regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.78672948
62regulation of glucose import in response to insulin stimulus (GO:2001273)3.76048761
63hair cycle process (GO:0022405)3.71966057
64molting cycle process (GO:0022404)3.71966057
65keratinocyte differentiation (GO:0030216)3.70840091
66endoplasmic reticulum unfolded protein response (GO:0030968)3.70213633
67protein N-linked glycosylation via asparagine (GO:0018279)3.69926001
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69765281
69eyelid development in camera-type eye (GO:0061029)3.69731026
70epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.68876671
71peptidyl-asparagine modification (GO:0018196)3.67543039
72dendritic cell chemotaxis (GO:0002407)3.66774139
73L-serine transport (GO:0015825)3.64318297
74protein retention in ER lumen (GO:0006621)3.63147346
75response to endoplasmic reticulum stress (GO:0034976)3.59042802
76ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.57297314
77endothelial cell chemotaxis (GO:0035767)3.57162837
78cellular response to unfolded protein (GO:0034620)3.56791282
79COPII vesicle coating (GO:0048208)3.55268203
80germinal center formation (GO:0002467)3.53386728
81arginine metabolic process (GO:0006525)3.51198571
82regulation of nuclease activity (GO:0032069)3.47912979
83ER-nucleus signaling pathway (GO:0006984)3.47545626
84hepatocyte apoptotic process (GO:0097284)3.46399921
85protein N-linked glycosylation (GO:0006487)3.45280865
86head development (GO:0060322)3.42138579
87lymphocyte migration (GO:0072676)3.42020966
88citrulline metabolic process (GO:0000052)3.40923398
89cell redox homeostasis (GO:0045454)3.40603118
90regulation of endothelial cell chemotaxis (GO:2001026)3.37606024
91deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.36625799
92hemidesmosome assembly (GO:0031581)3.34662536
93mannose metabolic process (GO:0006013)3.33797564
94oxygen transport (GO:0015671)3.32885425
95establishment of skin barrier (GO:0061436)3.28858071
96cellular response to antibiotic (GO:0071236)3.24174496
97cellular response to topologically incorrect protein (GO:0035967)3.24025011
98UDP-N-acetylglucosamine metabolic process (GO:0006047)3.22250483
99cysteine metabolic process (GO:0006534)3.21905855
100cell wall macromolecule catabolic process (GO:0016998)3.21632107
101cell wall macromolecule metabolic process (GO:0044036)3.21632107
102serine transport (GO:0032329)3.18359477
103gonadal mesoderm development (GO:0007506)3.16805358
104positive regulation of hair follicle development (GO:0051798)3.15169966
105positive regulation of hair cycle (GO:0042635)3.15169966
106long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.14073905
107nucleobase-containing small molecule interconversion (GO:0015949)3.11412026
108regulation of water loss via skin (GO:0033561)3.09847468
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06348340
110T-helper cell differentiation (GO:0042093)3.04992632
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.04992632
112regulation of lipoprotein particle clearance (GO:0010984)3.04923145
113regulation of hair cycle (GO:0042634)3.03182081
114cAMP-mediated signaling (GO:0019933)3.01425955
115activation of Ras GTPase activity (GO:0032856)3.00374026
116molting cycle (GO:0042303)21.9061587
117hair cycle (GO:0042633)21.9061587
118N-acetylneuraminate metabolic process (GO:0006054)2.98267845
119regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.97323959
120epidermal cell differentiation (GO:0009913)2.95697422
121interleukin-6-mediated signaling pathway (GO:0070102)2.95431281
122nucleotide-sugar biosynthetic process (GO:0009226)2.93595599
123intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.91687875
124regulation of viral release from host cell (GO:1902186)2.91601869
125regulation of podosome assembly (GO:0071801)2.90729502
126skin morphogenesis (GO:0043589)2.89712559
127linoleic acid metabolic process (GO:0043651)2.89005992
128long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.87464966
129regulation of cholesterol homeostasis (GO:2000188)2.87264231
130activation of Rho GTPase activity (GO:0032862)2.86296735
131hair follicle development (GO:0001942)2.84361925
132mitochondrion distribution (GO:0048311)2.82374133
133fatty-acyl-CoA biosynthetic process (GO:0046949)2.78358535
134negative regulation of viral release from host cell (GO:1902187)2.77937426
135negative regulation of necroptotic process (GO:0060546)2.77148590
136snRNA transcription (GO:0009301)2.76950617
137signal peptide processing (GO:0006465)2.76723613
138regulation of fibroblast apoptotic process (GO:2000269)2.76120948
139regulation of monocyte chemotaxis (GO:0090025)2.73887653
140leukotriene biosynthetic process (GO:0019370)2.72760826
141SMAD protein complex assembly (GO:0007183)2.70101174
142positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.68805394
143positive regulation of natural killer cell mediated immunity (GO:0002717)2.68805394
144regulation of granulocyte chemotaxis (GO:0071622)2.64982111
145deoxyribonucleotide biosynthetic process (GO:0009263)2.62717855
146dendritic cell migration (GO:0036336)2.60233301
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59195849
148response to unfolded protein (GO:0006986)2.58387254
149proline biosynthetic process (GO:0006561)2.58010367
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.56618589
151regulation of T cell chemotaxis (GO:0010819)2.56576168
152positive regulation of T cell chemotaxis (GO:0010820)2.56576168
153lymphocyte chemotaxis (GO:0048247)2.56137666
154GDP-mannose metabolic process (GO:0019673)2.55930073
155peptidyl-arginine modification (GO:0018195)2.55767488
156heterotypic cell-cell adhesion (GO:0034113)2.55625840
157positive regulation of protein homooligomerization (GO:0032464)2.54884155
158positive regulation of interleukin-4 production (GO:0032753)2.53966621
159protein import into peroxisome matrix (GO:0016558)2.53886815
160keratinocyte development (GO:0003334)2.52950086
161regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.52651431
162positive regulation of antigen processing and presentation (GO:0002579)2.51948622
163T cell proliferation (GO:0042098)2.50363196
164regulation of histone H3-K27 methylation (GO:0061085)2.49953169
165NIK/NF-kappaB signaling (GO:0038061)2.48859520
166positive regulation of keratinocyte differentiation (GO:0045618)2.48777290
167negative regulation of execution phase of apoptosis (GO:1900118)2.47950607
168T cell differentiation involved in immune response (GO:0002292)2.47057673
169alpha-beta T cell differentiation involved in immune response (GO:0002293)2.47057673
170alpha-beta T cell activation involved in immune response (GO:0002287)2.47057673
171peptide catabolic process (GO:0043171)2.46786946
172thioester biosynthetic process (GO:0035384)2.45309022
173acyl-CoA biosynthetic process (GO:0071616)2.45309022
174protein heterotetramerization (GO:0051290)2.44289439
175regulation of necroptotic process (GO:0060544)2.43765598
176glycosphingolipid catabolic process (GO:0046479)2.43753617
177cellular response to arsenic-containing substance (GO:0071243)2.41950623
178retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41332665
179response to topologically incorrect protein (GO:0035966)2.38270632
180mitochondrial calcium ion transport (GO:0006851)2.37791663
181cellular response to virus (GO:0098586)2.37234990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.19334960
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.28654310
3E2F7_22180533_ChIP-Seq_HELA_Human3.94626969
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.72181038
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.72192738
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69428636
7MYC_22102868_ChIP-Seq_BL_Human2.32262517
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.14986300
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04688036
10KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93752475
11ERG_21242973_ChIP-ChIP_JURKAT_Human1.91138176
12TFEB_21752829_ChIP-Seq_HELA_Human1.89331907
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.89035131
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88262311
15NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.85354280
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85189347
17LXR_22292898_ChIP-Seq_THP-1_Human1.83927912
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80753725
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.74734322
20TP53_20018659_ChIP-ChIP_R1E_Mouse1.73087558
21ATF3_27146783_Chip-Seq_COLON_Human1.72239771
22RACK7_27058665_Chip-Seq_MCF-7_Human1.71939787
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71895080
24CTCF_20526341_ChIP-Seq_ESCs_Human1.68758353
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68538607
26VDR_21846776_ChIP-Seq_THP-1_Human1.61935105
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60843747
28MYB_26560356_Chip-Seq_TH1_Human1.59986907
29HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.57803566
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55180955
31TCF7_22412390_ChIP-Seq_EML_Mouse1.54212941
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52746465
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51920816
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51287162
35EGR1_19032775_ChIP-ChIP_M12_Human1.51246223
36MAF_26560356_Chip-Seq_TH1_Human1.50287086
37CTCF_27219007_Chip-Seq_Bcells_Human1.47435420
38TP63_22573176_ChIP-Seq_HFKS_Human1.46529409
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45988384
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45521367
41ZNF263_19887448_ChIP-Seq_K562_Human1.45409950
42SMC4_20622854_ChIP-Seq_HELA_Human1.44605281
43DROSHA_22980978_ChIP-Seq_HELA_Human1.43840569
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43813483
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.43697897
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43443784
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42423419
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41449311
49MAF_26560356_Chip-Seq_TH2_Human1.40569894
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.37265549
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37249392
52* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.37141512
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37135401
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36432176
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36034454
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35240630
57NCOR1_26117541_ChIP-Seq_K562_Human1.34679874
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.34576426
59KDM5A_27292631_Chip-Seq_BREAST_Human1.34274196
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34067264
61MYB_26560356_Chip-Seq_TH2_Human1.34065213
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33587586
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32315110
64UTX_26944678_Chip-Seq_JUKART_Human1.31938912
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29432053
66BCOR_27268052_Chip-Seq_Bcells_Human1.29279005
67CHD1_26751641_Chip-Seq_LNCaP_Human1.29099776
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28674727
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28605238
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28050459
71BCL6_27268052_Chip-Seq_Bcells_Human1.27879097
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27541284
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27442288
74* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26762513
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26304686
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.26142429
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25130936
78* ERG_20517297_ChIP-Seq_VCAP_Human1.23949566
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23872017
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23350691
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22985358
82DCP1A_22483619_ChIP-Seq_HELA_Human1.21201991
83SCL_19346495_ChIP-Seq_HPC-7_Human1.20941583
84GATA1_22025678_ChIP-Seq_K562_Human1.20931850
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20660451
86MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.19988781
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19372630
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17431609
89GATA6_25053715_ChIP-Seq_YYC3_Human1.16662150
90CLOCK_20551151_ChIP-Seq_293T_Human1.16437073
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.16336541
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16243917
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.15899439
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.15621227
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14947634
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14741857
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14673885
98E2F1_20622854_ChIP-Seq_HELA_Human1.13903145
99* P53_21459846_ChIP-Seq_SAOS-2_Human1.13700094
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13333165
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13203621
102AR_21909140_ChIP-Seq_LNCAP_Human1.12652214
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12387916
104* FOXO3_23340844_ChIP-Seq_DLD1_Human1.10501130
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.10420471
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09511917
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09357147
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08978414
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08886070
110SOX2_20726797_ChIP-Seq_SW620_Human1.08811835
111GATA3_24758297_ChIP-Seq_MCF-7_Human1.08545797
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08154944
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07287674
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07261482
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06726606
116CEBPB_22108803_ChIP-Seq_LS180_Human1.06175838
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04917897
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04451279
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03904895
120ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03836252
121VDR_24763502_ChIP-Seq_THP-1_Human1.03430278
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03060367
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03046244
124ELK3_25401928_ChIP-Seq_HUVEC_Human1.02865006
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02666988
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02513284
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02448068
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02321365
129SPI1_20517297_ChIP-Seq_HL60_Human1.02121539
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02017812
131TAF2_19829295_ChIP-Seq_ESCs_Human1.01721449
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00635359
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99907633
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.99174648
135EZH2_27304074_Chip-Seq_ESCs_Mouse0.98898873
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98542697
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98542697
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97651158
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.97602433
140GATA4_25053715_ChIP-Seq_YYC3_Human0.97593968
141EGR1_19374776_ChIP-ChIP_THP-1_Human0.97566267
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97420953
143FOXH1_21741376_ChIP-Seq_ESCs_Human0.96982146
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95668645
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.95003275
146GATA1_19941826_ChIP-Seq_K562_Human0.94581688
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94058781
148GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93947191
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93354098
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.93327246
151CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93147209
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93143446
153NANOG_20526341_ChIP-Seq_ESCs_Human0.92973993
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.92418017
155PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92215151
156KLF5_25053715_ChIP-Seq_YYC3_Human0.92212216
157RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92119409
158TP63_23658742_ChIP-Seq_EP156T_Human0.91909381
159GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91601158
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91017851
161STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90821894
162ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90623579
163EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88872374
164RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88872374
165SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88094195
166AR_21572438_ChIP-Seq_LNCaP_Human0.87698814
167TP53_22127205_ChIP-Seq_IMR90_Human0.87677968
168PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87463501
169SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85885374
170GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85584166
171SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85010345
172YY1_22570637_ChIP-Seq_MALME-3M_Human0.84049437
173JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83667048
174AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82716349
175RAC3_21632823_ChIP-Seq_H3396_Human0.82353067
176ARNT_22903824_ChIP-Seq_MCF-7_Human0.81787744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.48139613
2MP0000579_abnormal_nail_morphology5.88140143
3MP0002098_abnormal_vibrissa_morphology5.36501950
4MP0002796_impaired_skin_barrier4.94106424
5MP0003705_abnormal_hypodermis_morpholog4.75306459
6MP0000647_abnormal_sebaceous_gland4.45567722
7MP0005275_abnormal_skin_tensile3.58380930
8MP0000383_abnormal_hair_follicle3.55971652
9MP0001346_abnormal_lacrimal_gland3.43478368
10MP0010352_gastrointestinal_tract_polyps3.19108235
11MP0010234_abnormal_vibrissa_follicle3.14072223
12MP0000427_abnormal_hair_cycle3.12941841
13MP0010678_abnormal_skin_adnexa3.01340043
14MP0000377_abnormal_hair_follicle2.97152834
15MP0005501_abnormal_skin_physiology2.79364734
16MP0003453_abnormal_keratinocyte_physiol2.72960525
17MP0001348_abnormal_lacrimal_gland2.50008941
18MP0005645_abnormal_hypothalamus_physiol2.37091845
19MP0002876_abnormal_thyroid_physiology2.27531667
20MP0003959_abnormal_lean_body2.26970380
21MP0004043_abnormal_pH_regulation2.21627697
22MP0003300_gastrointestinal_ulcer2.18180693
23MP0002060_abnormal_skin_morphology2.13653788
24MP0008260_abnormal_autophagy2.12722292
25MP0001216_abnormal_epidermal_layer2.11398825
26MP0000367_abnormal_coat/_hair1.99081566
27MP0010030_abnormal_orbit_morphology1.92280277
28MP0001501_abnormal_sleep_pattern1.90611567
29MP0001790_abnormal_immune_system1.88307033
30MP0005387_immune_system_phenotype1.88307033
31MP0010771_integument_phenotype1.82175512
32MP0009333_abnormal_splenocyte_physiolog1.79343964
33MP0000685_abnormal_immune_system1.76512522
34MP0003303_peritoneal_inflammation1.75246140
35MP0001243_abnormal_dermal_layer1.67933274
36MP0002163_abnormal_gland_morphology1.67576891
37MP0001835_abnormal_antigen_presentation1.53547062
38MP0003656_abnormal_erythrocyte_physiolo1.53170324
39MP0003950_abnormal_plasma_membrane1.45655996
40MP0008438_abnormal_cutaneous_collagen1.44990827
41MP0004947_skin_inflammation1.44631444
42MP0000467_abnormal_esophagus_morphology1.44572671
43MP0000762_abnormal_tongue_morphology1.43557275
44MP0000003_abnormal_adipose_tissue1.36302364
45MP0005058_abnormal_lysosome_morphology1.36041713
46MP0003566_abnormal_cell_adhesion1.35813234
47MP0005076_abnormal_cell_differentiation1.33509320
48MP0004381_abnormal_hair_follicle1.32229683
49MP0005220_abnormal_exocrine_pancreas1.29965061
50MP0002089_abnormal_postnatal_growth/wei1.27469508
51MP0002933_joint_inflammation1.23870064
52MP0002396_abnormal_hematopoietic_system1.22665749
53MP0001800_abnormal_humoral_immune1.20120129
54MP0002282_abnormal_trachea_morphology1.18062596
55MP0003436_decreased_susceptibility_to1.17304384
56MP0005647_abnormal_sex_gland1.16129400
57MP0009840_abnormal_foam_cell1.16128736
58MP0008995_early_reproductive_senescence1.14818710
59MP0005379_endocrine/exocrine_gland_phen1.14013505
60MP0003890_abnormal_embryonic-extraembry1.12522097
61MP0008004_abnormal_stomach_pH1.10418000
62MP0001881_abnormal_mammary_gland1.09970954
63MP0003183_abnormal_peptide_metabolism1.09657263
64MP0002009_preneoplasia1.08830729
65MP0005666_abnormal_adipose_tissue1.08193522
66MP0001873_stomach_inflammation1.08104596
67MP0001765_abnormal_ion_homeostasis1.06566078
68MP0006035_abnormal_mitochondrial_morpho1.05778361
69MP0005451_abnormal_body_composition1.05098539
70MP0009931_abnormal_skin_appearance1.03991421
71MP0009053_abnormal_anal_canal1.02957569
72MP0004885_abnormal_endolymph0.99538839
73MP0002452_abnormal_antigen_presenting0.96011789
74MP0005464_abnormal_platelet_physiology0.95451287
75MP0002398_abnormal_bone_marrow0.94014017
76MP0000716_abnormal_immune_system0.93559240
77MP0003693_abnormal_embryo_hatching0.93532270
78MP0002723_abnormal_immune_serum0.90004504
79MP0003763_abnormal_thymus_physiology0.89978207
80MP0001845_abnormal_inflammatory_respons0.89205938
81MP0003191_abnormal_cellular_cholesterol0.89104270
82MP0002420_abnormal_adaptive_immunity0.87501611
83MP0008057_abnormal_DNA_replication0.87359972
84MP0004510_myositis0.86858047
85MP0001819_abnormal_immune_cell0.86499205
86MP0002429_abnormal_blood_cell0.84800425
87MP0002722_abnormal_immune_system0.84394029
88MP0004782_abnormal_surfactant_physiolog0.81407113
89MP0005621_abnormal_cell_physiology0.80342136
90MP0009643_abnormal_urine_homeostasis0.79913380
91MP0000358_abnormal_cell_content/0.78557509
92MP0003091_abnormal_cell_migration0.78500028
93MP0005310_abnormal_salivary_gland0.78425196
94MP0000858_altered_metastatic_potential0.78265051
95MP0002877_abnormal_melanocyte_morpholog0.76459198
96MP0006082_CNS_inflammation0.75881811
97MP0003638_abnormal_response/metabolism_0.75845571
98MP0010307_abnormal_tumor_latency0.75438341
99MP0002136_abnormal_kidney_physiology0.72698769
100MP0004185_abnormal_adipocyte_glucose0.71735877
101MP0000470_abnormal_stomach_morphology0.71134949
102MP0001851_eye_inflammation0.71001808
103MP0004264_abnormal_extraembryonic_tissu0.69988157
104MP0000703_abnormal_thymus_morphology0.69283461
105MP0002909_abnormal_adrenal_gland0.68254577
106MP0009697_abnormal_copulation0.67750569
107MP0005000_abnormal_immune_tolerance0.67576011
108MP0005384_cellular_phenotype0.65950125
109MP0001191_abnormal_skin_condition0.65760069
110MP0003786_premature_aging0.64787768
111MP0002970_abnormal_white_adipose0.64727975
112MP0000689_abnormal_spleen_morphology0.64202002
113MP0001270_distended_abdomen0.63966361
114MP0004233_abnormal_muscle_weight0.63710119
115MP0003111_abnormal_nucleus_morphology0.63342053
116MP0004808_abnormal_hematopoietic_stem0.61812702
117MP0001340_abnormal_eyelid_morphology0.61776690
118MP0000613_abnormal_salivary_gland0.60612106
119MP0005375_adipose_tissue_phenotype0.60357826
120MP0002148_abnormal_hypersensitivity_rea0.60326412
121MP0003755_abnormal_palate_morphology0.57694423
122MP0009278_abnormal_bone_marrow0.56881812
123MP0005266_abnormal_metabolism0.56824839
124MP0001661_extended_life_span0.55635806
125MP0003283_abnormal_digestive_organ0.55593660
126MP0002234_abnormal_pharynx_morphology0.53105995
127MP0000627_abnormal_mammary_gland0.52973651
128MP0004270_analgesia0.51187818
129MP0002971_abnormal_brown_adipose0.51114679
130MP0003941_abnormal_skin_development0.50940446
131MP0005023_abnormal_wound_healing0.48503877
132MP0002405_respiratory_system_inflammati0.47742404
133MP0010155_abnormal_intestine_physiology0.45860125
134MP0003448_altered_tumor_morphology0.43721285
135MP0005452_abnormal_adipose_tissue0.42520022
136MP0009115_abnormal_fat_cell0.41794068
137MP0000538_abnormal_urinary_bladder0.38997451
138MP0004742_abnormal_vestibular_system0.38520536
139MP0008874_decreased_physiological_sensi0.36446357
140MP0002249_abnormal_larynx_morphology0.33919242
141MP0005377_hearing/vestibular/ear_phenot0.33309533
142MP0003878_abnormal_ear_physiology0.33309533
143MP0003075_altered_response_to0.33107398
144MP0003045_fibrosis0.32320381
145MP0000049_abnormal_middle_ear0.31214387
146MP0000631_abnormal_neuroendocrine_gland0.30429682
147MP0000639_abnormal_adrenal_gland0.28887898
148MP0003385_abnormal_body_wall0.28824350
149MP0002166_altered_tumor_susceptibility0.27699259
150MP0001784_abnormal_fluid_regulation0.27532742
151MP0000343_altered_response_to0.27237992
152MP0008872_abnormal_physiological_respon0.26356560
153MP0005085_abnormal_gallbladder_physiolo0.24768416
154MP0002006_tumorigenesis0.23794339
155MP0002277_abnormal_respiratory_mucosa0.23610734
156MP0005025_abnormal_response_to0.22957851

Predicted human phenotypes

RankGene SetZ-score
1Double outlet right ventricle (HP:0001719)9.07315461
2Congenital malformation of the right heart (HP:0011723)9.07315461
3Slow-growing hair (HP:0002217)8.01535532
4Abnormality of hair growth rate (HP:0011363)8.01535532
5Woolly hair (HP:0002224)7.85662874
6Brittle hair (HP:0002299)7.30146674
7Pili torti (HP:0003777)6.22098745
8Nail dystrophy (HP:0008404)5.97691266
9Hyperactive renin-angiotensin system (HP:0000841)5.77482630
10Decreased circulating renin level (HP:0003351)5.21007446
11Dry hair (HP:0011359)5.08251947
12Alopecia of scalp (HP:0002293)4.97017555
13Truncus arteriosus (HP:0001660)4.78948020
14Right ventricular cardiomyopathy (HP:0011663)4.48167117
15Fine hair (HP:0002213)4.41986735
16Hyperkalemia (HP:0002153)4.32003424
17Abnormality of nail color (HP:0100643)4.09817809
18Xerostomia (HP:0000217)4.04490174
19Transposition of the great arteries (HP:0001669)3.95016716
20Abnormal connection of the cardiac segments (HP:0011545)3.95016716
21Abnormal ventriculo-arterial connection (HP:0011563)3.95016716
22Nuclear cataract (HP:0100018)3.87537359
23Palmoplantar hyperkeratosis (HP:0000972)3.85314588
24Abnormal hair laboratory examination (HP:0003328)3.84308913
25Abnormality of liposaccharide metabolism (HP:0010968)3.83478899
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.83478899
27Abnormality of glycolipid metabolism (HP:0010969)3.83478899
28Hypokalemic alkalosis (HP:0001949)3.82768956
29Eczematoid dermatitis (HP:0000976)3.70446738
30Onycholysis (HP:0001806)3.69663556
31Fragile nails (HP:0001808)3.65087792
32Palmar hyperkeratosis (HP:0010765)3.56972279
33Increased IgE level (HP:0003212)3.47015686
34Plantar hyperkeratosis (HP:0007556)3.40241511
35Chronic bronchitis (HP:0004469)3.38776180
36Lip pit (HP:0100267)3.29034131
37Chronic mucocutaneous candidiasis (HP:0002728)3.12602611
38Recurrent cutaneous fungal infections (HP:0011370)3.12602611
39Amelogenesis imperfecta (HP:0000705)3.07958829
40Follicular hyperkeratosis (HP:0007502)3.05346641
41Milia (HP:0001056)3.02942951
42Hyponatremia (HP:0002902)3.02563553
43Oral leukoplakia (HP:0002745)3.01815580
44Rectal prolapse (HP:0002035)2.97902613
45Thick nail (HP:0001805)2.87553946
46Cone-rod dystrophy (HP:0000548)2.85647814
47Hypertensive crisis (HP:0100735)2.85339264
48Absent eyelashes (HP:0000561)2.80277903
49Growth hormone deficiency (HP:0000824)2.78096878
50Aplasia cutis congenita (HP:0001057)2.78022553
51Abnormality of chloride homeostasis (HP:0011422)2.72288267
52Renal salt wasting (HP:0000127)2.69188002
53Hyperaldosteronism (HP:0000859)2.59602272
54Sparse eyelashes (HP:0000653)2.50373254
55J-shaped sella turcica (HP:0002680)2.49242735
56Erythema (HP:0010783)2.48795532
57Hematochezia (HP:0002573)2.48330141
58Zonular cataract (HP:0010920)2.46758619
59Blepharitis (HP:0000498)2.45937931
60Keratoconjunctivitis (HP:0001096)2.44961536
61Concave nail (HP:0001598)2.35977803
62Colon cancer (HP:0003003)2.35327839
63Abnormality of sodium homeostasis (HP:0010931)2.31702253
64Abnormality of renin-angiotensin system (HP:0000847)2.29680400
65Hypercortisolism (HP:0001578)2.29672438
66Interstitial pulmonary disease (HP:0006530)2.29048164
67Absent eyebrow (HP:0002223)2.28832681
68Mucosal telangiectasiae (HP:0100579)2.28433073
69Ankyloglossia (HP:0010296)2.24110112
70Bronchitis (HP:0012387)2.23342598
71Flat acetabular roof (HP:0003180)2.21825683
72Recurrent fungal infections (HP:0002841)2.21017966
73Ventricular tachycardia (HP:0004756)2.20717486
74Sparse scalp hair (HP:0002209)2.20324855
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19136648
76Recurrent skin infections (HP:0001581)2.15286361
77Slow saccadic eye movements (HP:0000514)2.13136570
78Abnormality of the gastric mucosa (HP:0004295)2.13074423
79Hypokinesia (HP:0002375)2.12891986
80Abnormality of the frontal sinuses (HP:0002687)2.12008300
81Amniotic constriction ring (HP:0009775)2.08819535
82Abnormality of placental membranes (HP:0011409)2.08819535
83Difficulty walking (HP:0002355)2.05612966
84Vertebral arch anomaly (HP:0008438)2.05549402
85Abnormal tarsal ossification (HP:0008369)2.03645947
86Dysostosis multiplex (HP:0000943)2.03624224
87Spontaneous hematomas (HP:0007420)2.03471057
88Widely patent fontanelles and sutures (HP:0004492)2.00876495
89Vertebral compression fractures (HP:0002953)2.00745978
90Urethral obstruction (HP:0000796)2.00380667
91Hypotrichosis (HP:0001006)11.5321095
92Recurrent bacterial skin infections (HP:0005406)1.99674139
93Adrenal overactivity (HP:0002717)1.98387279
94Erythroderma (HP:0001019)1.96659050
95Congenital ichthyosiform erythroderma (HP:0007431)1.96183493
96Premature loss of primary teeth (HP:0006323)1.94034860
97Parakeratosis (HP:0001036)1.92006742
98Coarse hair (HP:0002208)1.91809179
99Seborrheic dermatitis (HP:0001051)1.90176946
100Neck muscle weakness (HP:0000467)1.90001724
101Abnormal blistering of the skin (HP:0008066)1.89978300
102Absent hair (HP:0002298)1.89354150
103Carpal bone hypoplasia (HP:0001498)1.88559734
104Corneal erosion (HP:0200020)1.87855131
105Abnormal foot bone ossification (HP:0010675)1.87044740
106Intention tremor (HP:0002080)1.86537798
107Mucopolysacchariduria (HP:0008155)1.86179559
108Urinary glycosaminoglycan excretion (HP:0003541)1.86179559
109Hypotension (HP:0002615)1.85213049
110Ridged nail (HP:0001807)1.82498488
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81661117
112Abnormality of polysaccharide metabolism (HP:0011012)1.81661117
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81661117
114Colitis (HP:0002583)1.79578093
115Recurrent gram-negative bacterial infections (HP:0005420)1.78059748
116Abnormality of the pupil (HP:0000615)1.78022431
117Abnormality of the aortic arch (HP:0012303)1.77916665
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.77813717
119Basal cell carcinoma (HP:0002671)1.75967588
120Abnormality of incisor morphology (HP:0011063)1.75239457
121Abnormality of T cell physiology (HP:0011840)1.73395740
122Brushfield spots (HP:0001088)1.72119747
123Torticollis (HP:0000473)1.72080243
124Sparse lateral eyebrow (HP:0005338)1.71821994
125Conical tooth (HP:0000698)1.69359292
126Congenital, generalized hypertrichosis (HP:0004540)1.69261403
127Hypohidrosis (HP:0000966)1.68731254
128Alkalosis (HP:0001948)1.67364956
129Overlapping toe (HP:0001845)1.66995165
130Severe visual impairment (HP:0001141)1.65661138
131Palmoplantar keratoderma (HP:0000982)1.65457118
132Progressive visual loss (HP:0000529)1.65145296
133Mitral valve prolapse (HP:0001634)1.64008244
134Small epiphyses (HP:0010585)1.62044365
135Poikiloderma (HP:0001029)1.62040248
136Annular pancreas (HP:0001734)1.61628545
137Natal tooth (HP:0000695)1.61548096
138Camptodactyly of toe (HP:0001836)1.61335973
139Autoimmune thrombocytopenia (HP:0001973)1.60854969
140Exocrine pancreatic insufficiency (HP:0001738)1.60831381
141Hyperthyroidism (HP:0000836)1.60114359
142Lower limb hyperreflexia (HP:0002395)1.59973941
143Hamartoma (HP:0010566)1.56401513
144Rhabdomyolysis (HP:0003201)1.56031998
145Autoimmune hemolytic anemia (HP:0001890)1.55294734
146Malnutrition (HP:0004395)1.55008013
147Mitral stenosis (HP:0001718)1.54940730
148Petechiae (HP:0000967)1.54927338
149Hyperparathyroidism (HP:0000843)1.54456322
150Type I diabetes mellitus (HP:0100651)1.54202905
151Abnormality of calcium-phosphate metabolism (HP:0100530)1.54052284
152Corneal dystrophy (HP:0001131)1.52779110
153Acanthosis nigricans (HP:0000956)1.52424756
154Pruritus (HP:0000989)1.50616957
155Acrocyanosis (HP:0001063)1.49164002
156Advanced eruption of teeth (HP:0006288)1.47896840
157Squamous cell carcinoma (HP:0002860)1.46097965
158Hypergammaglobulinemia (HP:0010702)1.44140707
159Fatigable weakness (HP:0003473)1.43920551
160Abnormality of the neuromuscular junction (HP:0003398)1.43920551
161Coronal craniosynostosis (HP:0004440)1.42997109
162Urticaria (HP:0001025)1.40682031
163Curly hair (HP:0002212)1.40641633
164Pustule (HP:0200039)1.40629880
165Back pain (HP:0003418)1.40152568
166Pterygium (HP:0001059)1.38274375
167Upper limb muscle weakness (HP:0003484)1.37663101
168Cholelithiasis (HP:0001081)1.35807151
169Craniofacial hyperostosis (HP:0004493)1.34549742
170Tongue fasciculations (HP:0001308)1.32993561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK4.57078386
2TAOK34.29422584
3PIM23.84825755
4PRKCI3.57877622
5EPHA33.41991642
6SIK33.21537718
7MAP3K113.08875400
8DDR22.97973156
9TNIK2.70858906
10MAP3K62.69150637
11IRAK32.63657177
12MST1R2.55301364
13FLT32.52044289
14NTRK12.48135418
15EPHB12.36695465
16EIF2AK32.31215615
17CCNB12.22113734
18PDGFRA2.21970926
19MAP2K22.18944823
20MAPK152.05027675
21ICK1.93066417
22MST41.87720828
23MET1.85840319
24EIF2AK11.82165536
25MATK1.81538976
26MELK1.77624646
27FER1.73450736
28LMTK21.70313687
29TYRO31.67969544
30PTK61.66164212
31MAP3K141.60784869
32RAF11.58341374
33ERBB31.57212420
34FGFR41.57158689
35DYRK1B1.56357821
36JAK31.46264435
37PAK41.42629924
38GRK61.41670760
39IRAK41.39762890
40LRRK21.35572258
41EPHA21.29640190
42MAP3K101.25688509
43TYK21.25230373
44BMX1.24169166
45MARK21.21746953
46SCYL21.19262576
47MAP3K31.17784671
48MAP2K31.17334350
49SMG11.14361853
50CDK61.10506599
51PKN21.05798942
52RPS6KB21.05598996
53STK101.04969520
54ITK1.01020530
55STK111.00118630
56EPHB20.95766356
57JAK20.92895940
58MAP4K10.92202381
59KSR10.90461261
60TRPM70.89002294
61RPS6KA40.88703431
62DYRK20.85869155
63FGR0.84997093
64MAP3K10.84683010
65TRIM280.84126134
66TNK20.83988405
67BTK0.83711363
68IRAK20.82892317
69ARAF0.82831956
70MAPKAPK30.82341332
71UHMK10.82022467
72STK40.80648258
73TEC0.80382316
74MAP4K20.79740054
75LATS20.78215226
76ALK0.76848250
77PIM10.76303446
78TRIB30.72973723
79CSK0.72241158
80CDK30.70127897
81HCK0.69514195
82TBK10.66425674
83KSR20.64364195
84MAP3K90.63721923
85IKBKB0.62605429
86MAP3K130.60936997
87BRAF0.58414452
88GSK3A0.58004235
89STK38L0.57747393
90MARK30.57373592
91BCR0.56841956
92TTN0.55768511
93TAOK20.55430441
94SGK30.53582490
95PTK20.52713034
96PRKD20.52639540
97PAK30.51712942
98TESK20.51333900
99MTOR0.51221053
100TAOK10.50770423
101BCKDK0.50650970
102PIK3CG0.49743443
103PINK10.48862412
104AKT30.47639504
105BRD40.46084732
106MAP3K70.45612651
107MAP2K60.45550534
108FGFR30.45477319
109ILK0.43855537
110ERN10.43051677
111CAMK1D0.42495873
112NME20.42377721
113HIPK20.41985962
114MAPKAPK20.40839892
115MAP3K80.40699682
116IRAK10.40003287
117MOS0.39191083
118RIPK10.37635405
119BMPR20.37367126
120AKT20.37124596
121RIPK40.37113430
122MAPK110.35914543
123PRKCD0.35130709
124MAPK70.34906228
125SYK0.34747139
126STK240.34488722
127PRKAA20.33360484
128YES10.33264093
129RPS6KB10.32954100
130PRPF4B0.31808151
131PLK10.31561116
132PHKG10.31558240
133PHKG20.31558240
134PAK60.31073238
135NME10.29611350
136SIK20.28442528
137EEF2K0.27996420
138PDPK10.27854260
139PDGFRB0.26959688
140CAMK2G0.25869523
141MAPK40.25839838
142PDK10.24969739
143MAP3K20.24419558
144DAPK10.23658562
145ZAP700.23135319
146CDK120.22099446
147CDC42BPA0.21974873
148SIK10.21250026
149IKBKE0.19829771
150MAPK30.18735275

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002205.86332035
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041415.07636488
3N-Glycan biosynthesis_Homo sapiens_hsa005104.16762683
4Dorso-ventral axis formation_Homo sapiens_hsa043203.95476068
5Asthma_Homo sapiens_hsa053103.83507439
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.39241792
7Linoleic acid metabolism_Homo sapiens_hsa005913.00450167
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.96654401
9Other glycan degradation_Homo sapiens_hsa005112.94195205
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.75152777
11Arginine and proline metabolism_Homo sapiens_hsa003302.72882538
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.59839294
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.29650470
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16381972
15Fatty acid biosynthesis_Homo sapiens_hsa000612.13062801
16Sphingolipid metabolism_Homo sapiens_hsa006002.01063686
17Vibrio cholerae infection_Homo sapiens_hsa051101.95556620
18Primary immunodeficiency_Homo sapiens_hsa053401.94506542
19Chronic myeloid leukemia_Homo sapiens_hsa052201.87140608
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.86255232
21Hippo signaling pathway_Homo sapiens_hsa043901.79640304
22Lysosome_Homo sapiens_hsa041421.71427704
23Non-small cell lung cancer_Homo sapiens_hsa052231.69944293
24Basal cell carcinoma_Homo sapiens_hsa052171.56365488
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54243573
26Pancreatic cancer_Homo sapiens_hsa052121.53902893
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48579099
28Melanoma_Homo sapiens_hsa052181.46702836
29Fat digestion and absorption_Homo sapiens_hsa049751.43191825
30Protein export_Homo sapiens_hsa030601.39490632
31Amoebiasis_Homo sapiens_hsa051461.39415370
32TGF-beta signaling pathway_Homo sapiens_hsa043501.37811527
33Biosynthesis of amino acids_Homo sapiens_hsa012301.36835658
34Adherens junction_Homo sapiens_hsa045201.33976212
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28442138
36VEGF signaling pathway_Homo sapiens_hsa043701.27964586
37Renal cell carcinoma_Homo sapiens_hsa052111.26853305
38Bladder cancer_Homo sapiens_hsa052191.22514606
39Acute myeloid leukemia_Homo sapiens_hsa052211.21663549
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21287224
41B cell receptor signaling pathway_Homo sapiens_hsa046621.20910512
42ABC transporters_Homo sapiens_hsa020101.20302351
43Glutathione metabolism_Homo sapiens_hsa004801.18946648
44Ether lipid metabolism_Homo sapiens_hsa005651.18908045
45Arachidonic acid metabolism_Homo sapiens_hsa005901.16004756
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14980757
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14503813
48Phenylalanine metabolism_Homo sapiens_hsa003601.14364003
49ErbB signaling pathway_Homo sapiens_hsa040121.13802626
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.09067381
51T cell receptor signaling pathway_Homo sapiens_hsa046601.06490486
52Inositol phosphate metabolism_Homo sapiens_hsa005621.05618792
53Measles_Homo sapiens_hsa051621.04523855
54Prostate cancer_Homo sapiens_hsa052151.04242741
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04121688
56Wnt signaling pathway_Homo sapiens_hsa043101.03984619
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99508998
58Histidine metabolism_Homo sapiens_hsa003400.98701942
59Base excision repair_Homo sapiens_hsa034100.97979292
60Hepatitis C_Homo sapiens_hsa051600.95839508
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95676324
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.94575373
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94376537
64Chemokine signaling pathway_Homo sapiens_hsa040620.93721682
65Steroid biosynthesis_Homo sapiens_hsa001000.91281779
66Hedgehog signaling pathway_Homo sapiens_hsa043400.89135876
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88625915
68Antigen processing and presentation_Homo sapiens_hsa046120.88242153
69Endometrial cancer_Homo sapiens_hsa052130.88071770
70Fructose and mannose metabolism_Homo sapiens_hsa000510.88009380
71Colorectal cancer_Homo sapiens_hsa052100.87867880
72Ras signaling pathway_Homo sapiens_hsa040140.87409643
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87257656
74FoxO signaling pathway_Homo sapiens_hsa040680.85648560
75Fatty acid elongation_Homo sapiens_hsa000620.85270951
76MAPK signaling pathway_Homo sapiens_hsa040100.83724892
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80745153
78Leishmaniasis_Homo sapiens_hsa051400.79543939
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79447985
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78849814
81Influenza A_Homo sapiens_hsa051640.78321879
82Proteoglycans in cancer_Homo sapiens_hsa052050.77553265
83Insulin signaling pathway_Homo sapiens_hsa049100.77328170
84MicroRNAs in cancer_Homo sapiens_hsa052060.77129831
85Melanogenesis_Homo sapiens_hsa049160.76994173
86p53 signaling pathway_Homo sapiens_hsa041150.76508780
87Salivary secretion_Homo sapiens_hsa049700.75968789
88Epstein-Barr virus infection_Homo sapiens_hsa051690.75589592
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74686146
90Small cell lung cancer_Homo sapiens_hsa052220.72408193
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.71518620
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70928556
93Osteoclast differentiation_Homo sapiens_hsa043800.69891127
94Mineral absorption_Homo sapiens_hsa049780.69269653
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68492695
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68292740
97Sulfur metabolism_Homo sapiens_hsa009200.67651064
98Fatty acid metabolism_Homo sapiens_hsa012120.66201143
99TNF signaling pathway_Homo sapiens_hsa046680.65624974
100Rap1 signaling pathway_Homo sapiens_hsa040150.63445606
101Pathways in cancer_Homo sapiens_hsa052000.62821768
102HTLV-I infection_Homo sapiens_hsa051660.61851830
103Glioma_Homo sapiens_hsa052140.61286378
104Viral carcinogenesis_Homo sapiens_hsa052030.60676127
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60181772
106Thyroid cancer_Homo sapiens_hsa052160.60151831
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.59722933
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59619232
109HIF-1 signaling pathway_Homo sapiens_hsa040660.59112712
110Pentose phosphate pathway_Homo sapiens_hsa000300.58726424
111Cell cycle_Homo sapiens_hsa041100.56105664
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55801688
113Tuberculosis_Homo sapiens_hsa051520.55797132
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54842860
115African trypanosomiasis_Homo sapiens_hsa051430.54796584
116Circadian rhythm_Homo sapiens_hsa047100.54468783
117Prolactin signaling pathway_Homo sapiens_hsa049170.53766651
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52774624
119Notch signaling pathway_Homo sapiens_hsa043300.52237957
120Endocytosis_Homo sapiens_hsa041440.52108419
121Galactose metabolism_Homo sapiens_hsa000520.51798871
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50603286
123Pertussis_Homo sapiens_hsa051330.50312490
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50000789
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49611686
126Proteasome_Homo sapiens_hsa030500.49460508
127Legionellosis_Homo sapiens_hsa051340.49167027
128Choline metabolism in cancer_Homo sapiens_hsa052310.48506719
129Vitamin digestion and absorption_Homo sapiens_hsa049770.48264882
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46588519
131Starch and sucrose metabolism_Homo sapiens_hsa005000.46364694
132Hepatitis B_Homo sapiens_hsa051610.45796787
133GnRH signaling pathway_Homo sapiens_hsa049120.45151359
134Gap junction_Homo sapiens_hsa045400.45029318
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44917305
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.44911341
137Collecting duct acid secretion_Homo sapiens_hsa049660.44437375
138Ovarian steroidogenesis_Homo sapiens_hsa049130.44249741
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43694697
140Axon guidance_Homo sapiens_hsa043600.43194288
141Protein digestion and absorption_Homo sapiens_hsa049740.42245408
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40397882
143Tyrosine metabolism_Homo sapiens_hsa003500.39570581
144Long-term depression_Homo sapiens_hsa047300.39447309
145Folate biosynthesis_Homo sapiens_hsa007900.39284881
146Long-term potentiation_Homo sapiens_hsa047200.38435678
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37619965
148Pyrimidine metabolism_Homo sapiens_hsa002400.37485524
149Olfactory transduction_Homo sapiens_hsa047400.37288380
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.36621759
151Glucagon signaling pathway_Homo sapiens_hsa049220.36553472
152NF-kappa B signaling pathway_Homo sapiens_hsa040640.35704892
153Herpes simplex infection_Homo sapiens_hsa051680.35208128
154PPAR signaling pathway_Homo sapiens_hsa033200.35072934
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34853542
156Estrogen signaling pathway_Homo sapiens_hsa049150.34814061
157Amphetamine addiction_Homo sapiens_hsa050310.34521241
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.34429984
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33971754
160ECM-receptor interaction_Homo sapiens_hsa045120.33128176
161Tight junction_Homo sapiens_hsa045300.32293987
162Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32197335
163Malaria_Homo sapiens_hsa051440.31835588
164PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31513827
165Focal adhesion_Homo sapiens_hsa045100.30897910
166Toxoplasmosis_Homo sapiens_hsa051450.30873090
167Apoptosis_Homo sapiens_hsa042100.29468343
168Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27069640
169Dilated cardiomyopathy_Homo sapiens_hsa054140.26897056
170Phospholipase D signaling pathway_Homo sapiens_hsa040720.25969818
171Maturity onset diabetes of the young_Homo sapiens_hsa049500.25503896
172Glycerophospholipid metabolism_Homo sapiens_hsa005640.25377629

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