GPRIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.23140830
2synaptic vesicle maturation (GO:0016188)6.14632107
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08382782
4vocalization behavior (GO:0071625)5.77037817
5layer formation in cerebral cortex (GO:0021819)5.73801876
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68541282
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.59663454
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.57472134
9protein localization to synapse (GO:0035418)5.18688626
10synaptic vesicle exocytosis (GO:0016079)5.17924413
11exploration behavior (GO:0035640)5.16255987
12regulation of glutamate receptor signaling pathway (GO:1900449)5.15144981
13neuron cell-cell adhesion (GO:0007158)5.14611632
14glutamate secretion (GO:0014047)5.13075137
15pyrimidine nucleobase catabolic process (GO:0006208)5.11933300
16dendritic spine morphogenesis (GO:0060997)4.96336951
17regulation of synaptic vesicle exocytosis (GO:2000300)4.94217373
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.78143251
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.48395879
20positive regulation of synapse maturation (GO:0090129)4.39011254
21regulation of synapse structural plasticity (GO:0051823)4.38257669
22neuron recognition (GO:0008038)4.34867705
23nucleobase catabolic process (GO:0046113)4.33091872
24regulation of synaptic vesicle transport (GO:1902803)4.32621690
25regulation of neuronal synaptic plasticity (GO:0048168)4.32394484
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31248855
27dendrite morphogenesis (GO:0048813)4.29134315
28neurotransmitter secretion (GO:0007269)4.20694762
29proline transport (GO:0015824)4.19674546
30neurotransmitter-gated ion channel clustering (GO:0072578)4.18127265
31axonal fasciculation (GO:0007413)4.13702590
32postsynaptic membrane organization (GO:0001941)4.10308771
33central nervous system projection neuron axonogenesis (GO:0021952)4.07208113
34synaptic transmission, glutamatergic (GO:0035249)4.00700468
35glutamate receptor signaling pathway (GO:0007215)4.00048490
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98681293
37cell migration in hindbrain (GO:0021535)3.97145479
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.97064996
39regulation of dendritic spine morphogenesis (GO:0061001)3.78246050
40gamma-aminobutyric acid transport (GO:0015812)3.77874073
41long-term memory (GO:0007616)3.72374323
42positive regulation of membrane potential (GO:0045838)3.71377990
43positive regulation of dendritic spine morphogenesis (GO:0061003)3.67682286
44activation of protein kinase A activity (GO:0034199)3.67196624
45neuron-neuron synaptic transmission (GO:0007270)3.60695438
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54403822
47neuronal ion channel clustering (GO:0045161)3.51254772
48negative regulation of dendrite morphogenesis (GO:0050774)3.45444744
49positive regulation of dendritic spine development (GO:0060999)3.43660949
50auditory behavior (GO:0031223)3.43480139
51neuromuscular process controlling balance (GO:0050885)3.43020669
52dendritic spine organization (GO:0097061)3.42497872
53clathrin coat assembly (GO:0048268)3.42337961
54synaptic vesicle endocytosis (GO:0048488)3.40461114
55regulation of postsynaptic membrane potential (GO:0060078)3.38222488
56negative regulation of microtubule polymerization (GO:0031115)3.36657720
57regulation of synaptic plasticity (GO:0048167)3.36306562
58neuronal action potential propagation (GO:0019227)3.35055159
59regulation of synapse maturation (GO:0090128)3.32201261
60establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.30139787
61mitochondrion transport along microtubule (GO:0047497)3.30139787
62cerebellar Purkinje cell layer development (GO:0021680)3.29653302
63neurotransmitter transport (GO:0006836)3.28473115
64cellular potassium ion homeostasis (GO:0030007)3.27229040
65synapse assembly (GO:0007416)3.26742430
66innervation (GO:0060384)3.26402728
67regulation of neurotransmitter secretion (GO:0046928)3.25541259
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24585465
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24443164
70organelle transport along microtubule (GO:0072384)3.23660206
71transmission of nerve impulse (GO:0019226)3.23069524
72regulation of dendritic spine development (GO:0060998)3.22056849
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19446965
74cell communication by electrical coupling (GO:0010644)3.19247024
75cerebellar granule cell differentiation (GO:0021707)3.19149768
76central nervous system neuron axonogenesis (GO:0021955)3.18158754
77sodium ion export (GO:0071436)3.17830010
78cerebellum development (GO:0021549)3.17691136
79regulation of NFAT protein import into nucleus (GO:0051532)3.17422975
80positive regulation of neurotransmitter transport (GO:0051590)3.15774366
81regulation of vesicle fusion (GO:0031338)3.15297239
82presynaptic membrane assembly (GO:0097105)3.15214650
83response to pheromone (GO:0019236)3.14118044
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13563116
85establishment of mitochondrion localization (GO:0051654)3.13143427
86axon extension (GO:0048675)3.12827494
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10799439
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10663503
89social behavior (GO:0035176)3.10006385
90intraspecies interaction between organisms (GO:0051703)3.10006385
91vesicle transport along microtubule (GO:0047496)3.09274009
92response to auditory stimulus (GO:0010996)3.09053762
93dopamine receptor signaling pathway (GO:0007212)3.08973172
94positive regulation of neurotransmitter secretion (GO:0001956)3.05202075
95regulation of ARF protein signal transduction (GO:0032012)3.01934660
96mechanosensory behavior (GO:0007638)3.01313975
97regulation of neurotransmitter levels (GO:0001505)3.00571035
98synapse organization (GO:0050808)3.00492671
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99655100
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.99226185
101presynaptic membrane organization (GO:0097090)2.98801726
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.98256166
103learning (GO:0007612)2.97594158
104long-term synaptic potentiation (GO:0060291)2.97509230
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97352704
106establishment of nucleus localization (GO:0040023)2.95654225
107axon cargo transport (GO:0008088)2.95354059
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.92555768
109gamma-aminobutyric acid signaling pathway (GO:0007214)2.91996320
110neuromuscular synaptic transmission (GO:0007274)2.88996919
111positive regulation of synapse assembly (GO:0051965)2.83601705
112neuromuscular process (GO:0050905)2.79503461
113regulation of voltage-gated calcium channel activity (GO:1901385)2.78410752
114neuron projection extension (GO:1990138)2.78373527
115regulation of dendrite morphogenesis (GO:0048814)2.78363503
116regulation of respiratory system process (GO:0044065)2.77830417
117mating behavior (GO:0007617)2.77238777
118regulation of neurotransmitter transport (GO:0051588)2.71140528
119amino acid import (GO:0043090)2.68497001
120regulation of respiratory gaseous exchange (GO:0043576)2.61979759
121negative regulation of dendrite development (GO:2000171)2.58164036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18508416
2GBX2_23144817_ChIP-Seq_PC3_Human3.15171586
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11882242
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08733571
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92300635
6REST_21632747_ChIP-Seq_MESCs_Mouse2.92034335
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74082611
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74082611
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.69921692
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66785141
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56685254
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54397495
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53245450
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53232971
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.51770632
16DROSHA_22980978_ChIP-Seq_HELA_Human2.51667496
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48684839
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.43389874
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43065897
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37031380
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.35661203
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33052801
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.32350378
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30774298
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22948663
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.20859381
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13430815
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09623102
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08589584
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96046541
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89728771
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87716621
33AR_21572438_ChIP-Seq_LNCaP_Human1.84714127
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64758662
35ZNF274_21170338_ChIP-Seq_K562_Hela1.64684265
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.59360517
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55803012
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.51709011
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50467171
40* LXR_22292898_ChIP-Seq_THP-1_Human1.50455501
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48608605
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42698046
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41908912
44SMAD4_21799915_ChIP-Seq_A2780_Human1.41316156
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40091007
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38201104
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.38066891
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38012642
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37203097
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35892525
51KDM2B_26808549_Chip-Seq_K562_Human1.35414488
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.31981949
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31510127
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.30154694
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29292916
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28628346
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27561550
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27468244
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.26374068
60* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23040245
61AR_19668381_ChIP-Seq_PC3_Human1.22162361
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20822289
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19988192
64IGF1R_20145208_ChIP-Seq_DFB_Human1.19291966
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18144766
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17290073
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17279915
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.15308414
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.14902181
70AR_25329375_ChIP-Seq_VCAP_Human1.13641063
71TAF15_26573619_Chip-Seq_HEK293_Human1.12490705
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11868302
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11608906
74RNF2_27304074_Chip-Seq_NSC_Mouse1.11456889
75P300_19829295_ChIP-Seq_ESCs_Human1.11249270
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10369082
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09977146
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.09863389
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09051035
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08886882
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.08518420
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08278709
83STAT3_23295773_ChIP-Seq_U87_Human1.08119403
84CREB1_26743006_Chip-Seq_LNCaP_Human1.08078598
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07767166
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07591345
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06339631
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06317187
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05885747
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05878261
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04868181
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04779398
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04283460
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.03804351
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03419208
96KDM2B_26808549_Chip-Seq_DND41_Human1.03037950
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.00517457
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00152406
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99634050
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99380189
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99372154
102SMC4_20622854_ChIP-Seq_HELA_Human0.99349845
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99167810
104AHR_22903824_ChIP-Seq_MCF-7_Human0.98180536
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.96681211
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96438290
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95707386
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95707386
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95038687
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94966760
111TCF4_23295773_ChIP-Seq_U87_Human0.94763422
112SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94181980
113SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92690570
114RACK7_27058665_Chip-Seq_MCF-7_Human0.91230653
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.91212319
116* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90831052
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.90798361
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90341512
119* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89526767
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.89493944
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88874633
122P68_20966046_ChIP-Seq_HELA_Human0.88699446
123CTCF_27219007_Chip-Seq_Bcells_Human0.87915123
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.87766115
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87615088
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87607098
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86668012
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86088595
129RUNX2_22187159_ChIP-Seq_PCA_Human0.85731640
130TP53_20018659_ChIP-ChIP_R1E_Mouse0.85626142
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85406770
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85152454
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84827720
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84693171
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84200134
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82700549
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82411505
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82208573
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82088292
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81940433
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81698716
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80265147
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79957320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.86119783
2MP0003880_abnormal_central_pattern4.24336090
3MP0003635_abnormal_synaptic_transmissio4.16837222
4MP0004270_analgesia4.13882813
5MP0002063_abnormal_learning/memory/cond3.47256001
6MP0005423_abnormal_somatic_nervous3.31186553
7MP0009745_abnormal_behavioral_response3.11223640
8MP0002734_abnormal_mechanical_nocicepti2.82867680
9MP0002064_seizures2.78301558
10MP0002572_abnormal_emotion/affect_behav2.69043870
11MP0001968_abnormal_touch/_nociception2.68832394
12MP0000778_abnormal_nervous_system2.66494671
13MP0009780_abnormal_chondrocyte_physiolo2.59486227
14MP0009046_muscle_twitch2.53064289
15MP0001486_abnormal_startle_reflex2.33134686
16MP0002735_abnormal_chemical_nociception2.28596751
17MP0002184_abnormal_innervation2.19146465
18MP0001440_abnormal_grooming_behavior2.16885255
19MP0002733_abnormal_thermal_nociception2.15124182
20MP0004858_abnormal_nervous_system2.13853697
21MP0003329_amyloid_beta_deposits2.13068549
22MP0002272_abnormal_nervous_system2.10184496
23MP0004811_abnormal_neuron_physiology2.06081750
24MP0002736_abnormal_nociception_after1.94398140
25MP0002557_abnormal_social/conspecific_i1.91991670
26MP0001970_abnormal_pain_threshold1.90412442
27MP0000955_abnormal_spinal_cord1.85407961
28MP0002909_abnormal_adrenal_gland1.83953574
29MP0002067_abnormal_sensory_capabilities1.80132491
30MP0003123_paternal_imprinting1.80027070
31MP0001501_abnormal_sleep_pattern1.75924528
32MP0008569_lethality_at_weaning1.73144386
33MP0004885_abnormal_endolymph1.72053368
34MP0005386_behavior/neurological_phenoty1.71292006
35MP0004924_abnormal_behavior1.71292006
36MP0005623_abnormal_meninges_morphology1.64160881
37MP0005645_abnormal_hypothalamus_physiol1.63014441
38MP0000569_abnormal_digit_pigmentation1.62902296
39MP0006276_abnormal_autonomic_nervous1.62336322
40MP0002882_abnormal_neuron_morphology1.58220905
41MP0001984_abnormal_olfaction1.53996490
42MP0003879_abnormal_hair_cell1.52191355
43MP0002066_abnormal_motor_capabilities/c1.43776908
44MP0003787_abnormal_imprinting1.41135414
45MP0002822_catalepsy1.39903817
46MP0002152_abnormal_brain_morphology1.36656900
47MP0005409_darkened_coat_color1.36191302
48MP0000579_abnormal_nail_morphology1.26974918
49MP0002249_abnormal_larynx_morphology1.23274053
50MP0000534_abnormal_ureter_morphology1.20458743
51MP0001346_abnormal_lacrimal_gland1.18146206
52MP0001502_abnormal_circadian_rhythm1.18111233
53MP0003633_abnormal_nervous_system1.17753138
54MP0005646_abnormal_pituitary_gland1.16184406
55MP0005187_abnormal_penis_morphology1.16020224
56MP0003122_maternal_imprinting1.10223210
57MP0000631_abnormal_neuroendocrine_gland1.07707397
58MP0002751_abnormal_autonomic_nervous1.05712971
59MP0003121_genomic_imprinting1.04447368
60MP0003631_nervous_system_phenotype1.03610311
61MP0005499_abnormal_olfactory_system1.03336900
62MP0005394_taste/olfaction_phenotype1.03336900
63MP0002069_abnormal_eating/drinking_beha1.00180057
64MP0003283_abnormal_digestive_organ0.99843040
65MP0003942_abnormal_urinary_system0.98587946
66MP0001348_abnormal_lacrimal_gland0.97305517
67MP0008961_abnormal_basal_metabolism0.96848581
68MP0003861_abnormal_nervous_system0.96277755
69MP0002081_perinatal_lethality0.94271960
70MP0001905_abnormal_dopamine_level0.93591043
71MP0003705_abnormal_hypodermis_morpholog0.93573833
72MP0000604_amyloidosis0.93144896
73MP0004142_abnormal_muscle_tone0.92340772
74MP0001188_hyperpigmentation0.91937163
75MP0004742_abnormal_vestibular_system0.90843450
76MP0005257_abnormal_intraocular_pressure0.89455370
77MP0003385_abnormal_body_wall0.88682441
78MP0010386_abnormal_urinary_bladder0.88629685
79MP0003634_abnormal_glial_cell0.88298018
80MP0002229_neurodegeneration0.85896770
81MP0001529_abnormal_vocalization0.84841824
82MP0002752_abnormal_somatic_nervous0.83657835
83MP0002234_abnormal_pharynx_morphology0.81574592
84MP0003632_abnormal_nervous_system0.80997981
85MP0001177_atelectasis0.79397610
86MP0000751_myopathy0.79373080
87MP0000462_abnormal_digestive_system0.78793769
88MP0004145_abnormal_muscle_electrophysio0.77966953
89MP0000013_abnormal_adipose_tissue0.77815465
90MP0002638_abnormal_pupillary_reflex0.77717236
91MP0001943_abnormal_respiration0.77519745
92MP0004085_abnormal_heartbeat0.77363549
93MP0003938_abnormal_ear_development0.77122348
94MP0001963_abnormal_hearing_physiology0.74638352
95MP0003119_abnormal_digestive_system0.74177675
96MP0005551_abnormal_eye_electrophysiolog0.73316102
97MP0002697_abnormal_eye_size0.72152774
98MP0002089_abnormal_postnatal_growth/wei0.69373219
99MP0009053_abnormal_anal_canal0.69349432
100MP0002837_dystrophic_cardiac_calcinosis0.69276707
101MP0005535_abnormal_body_temperature0.68417525
102MP0001299_abnormal_eye_distance/0.68241196
103MP0003137_abnormal_impulse_conducting0.67557625
104MP0000049_abnormal_middle_ear0.66622686
105MP0004233_abnormal_muscle_weight0.65434203
106MP0009672_abnormal_birth_weight0.64602031
107MP0002102_abnormal_ear_morphology0.63498002
108MP0005076_abnormal_cell_differentiation0.63294666
109MP0006072_abnormal_retinal_apoptosis0.62664574
110MP0002090_abnormal_vision0.62611744
111MP0000566_synostosis0.62360750
112MP0003115_abnormal_respiratory_system0.61774241
113MP0002116_abnormal_craniofacial_bone0.61424719
114MP0000537_abnormal_urethra_morphology0.61308361
115MP0008872_abnormal_physiological_respon0.61206917
116MP0004130_abnormal_muscle_cell0.60342632
117MP0010769_abnormal_survival0.60060580
118MP0010234_abnormal_vibrissa_follicle0.60006241
119MP0003075_altered_response_to0.59455977
120MP0004510_myositis0.59301241
121MP0003172_abnormal_lysosome_physiology0.58565522
122MP0010770_preweaning_lethality0.58298930
123MP0002082_postnatal_lethality0.58298930
124MP0008789_abnormal_olfactory_epithelium0.58226182
125MP0008874_decreased_physiological_sensi0.57341805
126MP0010768_mortality/aging0.56011026

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.05198305
2Focal motor seizures (HP:0011153)5.67651966
3Visual hallucinations (HP:0002367)5.26913157
4Focal seizures (HP:0007359)4.91097426
5Mutism (HP:0002300)4.26513407
6Epileptic encephalopathy (HP:0200134)4.21173113
7Supranuclear gaze palsy (HP:0000605)4.16945291
8Progressive cerebellar ataxia (HP:0002073)3.79570677
9Papilledema (HP:0001085)3.76735986
10Amyotrophic lateral sclerosis (HP:0007354)3.65393055
11Ankle clonus (HP:0011448)3.54924007
12Broad-based gait (HP:0002136)3.45986325
13Action tremor (HP:0002345)3.45086910
14Absence seizures (HP:0002121)3.42839377
15Poor eye contact (HP:0000817)3.38933506
16Atonic seizures (HP:0010819)3.37935651
17Cerebral inclusion bodies (HP:0100314)3.32341896
18Febrile seizures (HP:0002373)3.31395159
19Excessive salivation (HP:0003781)3.26911354
20Drooling (HP:0002307)3.26911354
21Neurofibrillary tangles (HP:0002185)3.25163504
22Generalized tonic-clonic seizures (HP:0002069)3.19065727
23Abnormality of the corticospinal tract (HP:0002492)3.18448741
24Dialeptic seizures (HP:0011146)3.05630344
25Limb dystonia (HP:0002451)3.03434855
26Impaired vibration sensation in the lower limbs (HP:0002166)3.03354605
27Depression (HP:0000716)3.03238694
28Abnormal social behavior (HP:0012433)2.98921432
29Impaired social interactions (HP:0000735)2.98921432
30Urinary bladder sphincter dysfunction (HP:0002839)2.97144992
31Abnormality of the lower motor neuron (HP:0002366)2.94751989
32Elfin facies (HP:0004428)2.94247960
33Genetic anticipation (HP:0003743)2.92609721
34Amblyopia (HP:0000646)2.92435781
35Megalencephaly (HP:0001355)2.89064278
36Overriding aorta (HP:0002623)2.83521691
37Hyperventilation (HP:0002883)2.83383656
38Termporal pattern (HP:0011008)2.82012353
39Insidious onset (HP:0003587)2.82012353
40Inappropriate behavior (HP:0000719)2.81652260
41Hemiparesis (HP:0001269)2.80379124
42Urinary urgency (HP:0000012)2.78956731
43Akinesia (HP:0002304)2.78907939
44Abnormality of binocular vision (HP:0011514)2.78562672
45Diplopia (HP:0000651)2.78562672
46Abnormal eating behavior (HP:0100738)2.78496481
47Polyphagia (HP:0002591)2.74594273
48Apathy (HP:0000741)2.74057195
49Obstructive sleep apnea (HP:0002870)2.68093892
50Epileptiform EEG discharges (HP:0011182)2.66824984
51EEG with generalized epileptiform discharges (HP:0011198)2.66771115
52Hypsarrhythmia (HP:0002521)2.60423266
53Anxiety (HP:0000739)2.59581994
54Insomnia (HP:0100785)2.59532262
55Torticollis (HP:0000473)2.59163372
56Truncal ataxia (HP:0002078)2.59089293
57Agitation (HP:0000713)2.59063223
58Spastic gait (HP:0002064)2.58392985
59Progressive inability to walk (HP:0002505)2.57401417
60Dysdiadochokinesis (HP:0002075)2.53457038
61Stereotypic behavior (HP:0000733)2.52606435
62Diminished motivation (HP:0000745)2.45624068
63Gaze-evoked nystagmus (HP:0000640)2.44857091
64Dysmetria (HP:0001310)2.42901698
65Renovascular hypertension (HP:0100817)2.42864695
66Focal dystonia (HP:0004373)2.42269703
67Postural instability (HP:0002172)2.41323864
68Impaired smooth pursuit (HP:0007772)2.36642823
69Turricephaly (HP:0000262)2.31708330
70Renal duplication (HP:0000075)2.26509844
71Bradykinesia (HP:0002067)2.25923673
72Fetal akinesia sequence (HP:0001989)2.25871994
73Intention tremor (HP:0002080)2.23691222
74Lower limb muscle weakness (HP:0007340)2.23267774
75Hypoventilation (HP:0002791)2.19974270
76Pachygyria (HP:0001302)2.19031082
77Morphological abnormality of the pyramidal tract (HP:0002062)2.17330953
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16764303
79Hypoplasia of the brainstem (HP:0002365)2.16764303
80Inability to walk (HP:0002540)2.15815080
81Craniofacial dystonia (HP:0012179)2.15033249
82Absent speech (HP:0001344)2.13792705
83Lissencephaly (HP:0001339)2.11307373
84Abnormality of salivation (HP:0100755)2.11128942
85Pointed chin (HP:0000307)2.10168685
86Aqueductal stenosis (HP:0002410)2.09550305
87Increased nuchal translucency (HP:0010880)2.06175079
88Annular pancreas (HP:0001734)2.06014731
89Cortical dysplasia (HP:0002539)2.05804293
90Hepatoblastoma (HP:0002884)2.05461705
91Abnormality of ocular smooth pursuit (HP:0000617)2.05259494
92Bowel diverticulosis (HP:0005222)1.99424687
93Shawl scrotum (HP:0000049)1.98115891
94Pheochromocytoma (HP:0002666)1.97602124
95Sleep apnea (HP:0010535)1.95942685
96Sporadic (HP:0003745)1.91033204
97Intellectual disability, profound (HP:0002187)1.89761249
98Hemiplegia (HP:0002301)1.89651979
99Broad distal phalanx of finger (HP:0009836)1.88869338
100Generalized myoclonic seizures (HP:0002123)1.88656274
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88274241
102Ventricular fibrillation (HP:0001663)1.87099018
103Neuronal loss in central nervous system (HP:0002529)1.86824260
104Hand muscle atrophy (HP:0009130)1.86550760
105Impaired vibratory sensation (HP:0002495)1.86507708
106Distal upper limb amyotrophy (HP:0007149)1.86271195
107Upper limb amyotrophy (HP:0009129)1.86271195
108Hammertoe (HP:0001765)1.86131144
109Clonus (HP:0002169)1.86021532
110Hyperacusis (HP:0010780)1.85348633
111Lower limb asymmetry (HP:0100559)1.84952690
112Disinhibition (HP:0000734)1.84705499
113Flat cornea (HP:0007720)1.84249001
114Megalocornea (HP:0000485)1.84120699
115Patellar dislocation (HP:0002999)1.82919735
116Obsessive-compulsive behavior (HP:0000722)1.81061995
117Failure to thrive in infancy (HP:0001531)1.78548406
118High anterior hairline (HP:0009890)1.77233786
119Hyperparathyroidism (HP:0000843)1.76476050
120Hypoplasia of the corpus callosum (HP:0002079)1.76449605
121Rapidly progressive (HP:0003678)1.76153780
122Lower limb amyotrophy (HP:0007210)1.75426933
123Sacral dimple (HP:0000960)1.75205830
124Hypercortisolism (HP:0001578)1.74102254
125Generalized hypotonia (HP:0001290)1.74060811
126Aplasia involving bones of the extremities (HP:0009825)1.71947965
127Aplasia involving bones of the upper limbs (HP:0009823)1.71947965
128Aplasia of the phalanges of the hand (HP:0009802)1.71947965
129Arnold-Chiari malformation (HP:0002308)1.71906212
130Hyperthyroidism (HP:0000836)1.71583418
131Hypercalcemia (HP:0003072)1.70925021
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70593190
133Precocious puberty (HP:0000826)1.69635999
134Exotropia (HP:0000577)1.68295285
135Long palpebral fissure (HP:0000637)1.65985340
136Open mouth (HP:0000194)1.65083351
137Trigonocephaly (HP:0000243)1.64872503
138Dysmetric saccades (HP:0000641)1.63346275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.48460594
2MAP3K94.07354619
3NTRK33.61812304
4EPHA43.10095987
5MINK12.88942263
6MAP3K42.76842772
7DAPK22.44463522
8NTRK22.36422000
9TRIB32.34764692
10PAK62.31888089
11MAP2K72.27111661
12KSR11.94376296
13KSR21.85141654
14CAMKK11.84741269
15MAPK131.82115254
16PHKG11.81433312
17PHKG21.81433312
18PRKD31.80915859
19SIK21.74862464
20EEF2K1.65809939
21LATS21.64034258
22MAP2K41.62133497
23CDK51.56684936
24NTRK11.51796503
25DYRK21.49836715
26DAPK11.33330774
27CASK1.33291907
28PLK21.32992971
29PNCK1.30363154
30MAP3K121.27199877
31ERBB31.22325681
32UHMK11.22222946
33MAP3K21.18721430
34TYRO31.14326869
35PRKCG1.14139706
36CAMK1D1.12980465
37GRK51.12300150
38TNIK1.11774239
39CDK121.06971221
40TAOK11.06716682
41CSNK1G21.05043477
42INSRR1.00790685
43MARK20.98702578
44TESK10.96806704
45PRPF4B0.96770694
46CDK180.96233900
47PAK30.95450129
48CDK150.95171274
49STK110.94124201
50SCYL20.93782305
51RET0.93624148
52DYRK1A0.93406725
53CDK140.92535904
54ALK0.87899121
55SMG10.87674634
56MAP3K100.85233390
57STK380.84542960
58CDK11A0.83433089
59PTK20.83381175
60RIPK40.80282236
61SIK10.80066209
62CDK190.78476179
63CAMK2A0.76921753
64FES0.75402191
65IRAK30.74811642
66PRKCZ0.73607300
67PDGFRA0.67551750
68CAMK10.67124312
69PRKCH0.67028208
70CAMKK20.66762832
71PKN10.66631260
72BRAF0.66436988
73PKN20.66373872
74MTOR0.62864168
75WNK30.62667145
76MAP3K60.62556450
77AURKA0.61100299
78SGK4940.60548249
79SGK2230.60548249
80RPS6KA20.59677896
81RIPK10.55732554
82RAF10.55136911
83CAMK2B0.54710102
84SGK10.53373354
85FYN0.52915957
86EPHB20.52807863
87MAPK120.52172162
88CAMK1G0.51668505
89CSNK1G30.49933950
90LIMK10.49569315
91CCNB10.48649949
92CAMK2G0.47605199
93CAMK40.47140199
94ICK0.47126026
95CSNK1G10.46917653
96CSNK1E0.46883753
97ARAF0.46744611
98TAOK20.46233057
99PRKCI0.45348386
100CDC70.45273440
101CSNK1A1L0.44566273
102TSSK60.42876854
103RPS6KA30.42533501
104CDK80.42251604
105MAP2K60.42086202
106CHEK20.42071006
107PRKAA10.42018109
108PRKCE0.41734512
109LMTK20.41291873
110PDK10.40662184
111GSK3B0.38244381
112CDC42BPA0.37493487
113SGK30.37156818
114SGK20.37085480
115PTK2B0.36852872
116FGFR20.36456741
117PRKDC0.36017136
118PDPK10.35729976
119FER0.35460464
120MAPK80.35214994
121BRSK10.34688606
122MAPK100.33362796
123MAPK90.33027400
124FGR0.31959348
125MAP2K10.31681370
126BCR0.30108693
127MAP3K10.28694935
128DAPK30.28335036
129DMPK0.28161983
130PRKCB0.27810954

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.32893695
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04678076
3Circadian entrainment_Homo sapiens_hsa047132.63022794
4Olfactory transduction_Homo sapiens_hsa047402.60590346
5Long-term potentiation_Homo sapiens_hsa047202.57704488
6GABAergic synapse_Homo sapiens_hsa047272.50828770
7Glutamatergic synapse_Homo sapiens_hsa047242.50761953
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49106010
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30122579
10Morphine addiction_Homo sapiens_hsa050322.29626791
11Amphetamine addiction_Homo sapiens_hsa050312.22231797
12Dopaminergic synapse_Homo sapiens_hsa047282.20889636
13Cholinergic synapse_Homo sapiens_hsa047252.01079042
14Salivary secretion_Homo sapiens_hsa049701.96508129
15Insulin secretion_Homo sapiens_hsa049111.96417916
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82222664
17Gastric acid secretion_Homo sapiens_hsa049711.78106077
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71021955
19Axon guidance_Homo sapiens_hsa043601.68765401
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67835417
21Long-term depression_Homo sapiens_hsa047301.67579986
22Oxytocin signaling pathway_Homo sapiens_hsa049211.63071331
23Renin secretion_Homo sapiens_hsa049241.59645755
24Serotonergic synapse_Homo sapiens_hsa047261.54023200
25Taste transduction_Homo sapiens_hsa047421.52777277
26Gap junction_Homo sapiens_hsa045401.51616569
27Cocaine addiction_Homo sapiens_hsa050301.50229622
28GnRH signaling pathway_Homo sapiens_hsa049121.48886432
29Vitamin B6 metabolism_Homo sapiens_hsa007501.48390126
30Type II diabetes mellitus_Homo sapiens_hsa049301.45197158
31Glioma_Homo sapiens_hsa052141.38059879
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37124846
33Estrogen signaling pathway_Homo sapiens_hsa049151.36265542
34Calcium signaling pathway_Homo sapiens_hsa040201.31578773
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27394769
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27200789
37ErbB signaling pathway_Homo sapiens_hsa040121.23507362
38cAMP signaling pathway_Homo sapiens_hsa040241.17310924
39Melanogenesis_Homo sapiens_hsa049161.16228354
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03435847
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02047534
42Endometrial cancer_Homo sapiens_hsa052131.00776733
43Oocyte meiosis_Homo sapiens_hsa041140.98730216
44Collecting duct acid secretion_Homo sapiens_hsa049660.97321389
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90545163
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.90333171
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88080025
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.86170378
49VEGF signaling pathway_Homo sapiens_hsa043700.85968205
50Notch signaling pathway_Homo sapiens_hsa043300.85946685
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84543700
52Phototransduction_Homo sapiens_hsa047440.84278603
53Dorso-ventral axis formation_Homo sapiens_hsa043200.82321698
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82042301
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81284307
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.80739648
57Choline metabolism in cancer_Homo sapiens_hsa052310.79983806
58mTOR signaling pathway_Homo sapiens_hsa041500.79856487
59Colorectal cancer_Homo sapiens_hsa052100.79143843
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78284115
61Hedgehog signaling pathway_Homo sapiens_hsa043400.78111355
62Basal cell carcinoma_Homo sapiens_hsa052170.77930898
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76158782
64Renal cell carcinoma_Homo sapiens_hsa052110.76071419
65Chronic myeloid leukemia_Homo sapiens_hsa052200.75422961
66Vibrio cholerae infection_Homo sapiens_hsa051100.75062268
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75037131
68MAPK signaling pathway_Homo sapiens_hsa040100.72068085
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71706900
70Thyroid hormone synthesis_Homo sapiens_hsa049180.71088629
71Cardiac muscle contraction_Homo sapiens_hsa042600.70456671
72Pancreatic secretion_Homo sapiens_hsa049720.70276383
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67151783
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66594742
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65878848
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.65861586
77Alcoholism_Homo sapiens_hsa050340.64922645
78Dilated cardiomyopathy_Homo sapiens_hsa054140.64318661
79Ras signaling pathway_Homo sapiens_hsa040140.64080731
80mRNA surveillance pathway_Homo sapiens_hsa030150.62161149
81Glucagon signaling pathway_Homo sapiens_hsa049220.61671648
82Non-small cell lung cancer_Homo sapiens_hsa052230.61536670
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60613430
84Insulin signaling pathway_Homo sapiens_hsa049100.60023152
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59770686
86Wnt signaling pathway_Homo sapiens_hsa043100.59272830
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58751353
88Adherens junction_Homo sapiens_hsa045200.57695924
89Rap1 signaling pathway_Homo sapiens_hsa040150.57534395
90Endocytosis_Homo sapiens_hsa041440.57473308
91Sulfur relay system_Homo sapiens_hsa041220.57431110
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57423021
93Prion diseases_Homo sapiens_hsa050200.55501380
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55459437
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55190320
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54222606
97MicroRNAs in cancer_Homo sapiens_hsa052060.53874443
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53429105
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50008904
100Thyroid cancer_Homo sapiens_hsa052160.47570061
101Melanoma_Homo sapiens_hsa052180.46390625
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45159408
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44471360
104Biosynthesis of amino acids_Homo sapiens_hsa012300.44440238
105Bile secretion_Homo sapiens_hsa049760.42472206
106Prolactin signaling pathway_Homo sapiens_hsa049170.41724457
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41251720
108Type I diabetes mellitus_Homo sapiens_hsa049400.39759012
109Chemokine signaling pathway_Homo sapiens_hsa040620.38105040
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37498456
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.35785452
112Nitrogen metabolism_Homo sapiens_hsa009100.35413908
113Inositol phosphate metabolism_Homo sapiens_hsa005620.34747746
114AMPK signaling pathway_Homo sapiens_hsa041520.33188107
115Hippo signaling pathway_Homo sapiens_hsa043900.32533336
116Ovarian steroidogenesis_Homo sapiens_hsa049130.31149699
117Tight junction_Homo sapiens_hsa045300.30500630
118Circadian rhythm_Homo sapiens_hsa047100.30121950

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