GPRIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.67241045
2L-phenylalanine catabolic process (GO:0006559)5.64997115
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.64997115
4negative T cell selection (GO:0043383)5.57054666
5negative thymic T cell selection (GO:0045060)5.45018554
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.25336191
7L-phenylalanine metabolic process (GO:0006558)5.23056615
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.23056615
9aromatic amino acid family catabolic process (GO:0009074)5.02966584
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.87335837
11regulation of B cell receptor signaling pathway (GO:0050855)4.86343795
12activated T cell proliferation (GO:0050798)4.79432584
13positive T cell selection (GO:0043368)4.79224685
14urea cycle (GO:0000050)4.61091433
15urea metabolic process (GO:0019627)4.61091433
16regulation of gamma-delta T cell differentiation (GO:0045586)4.60799733
17bile acid biosynthetic process (GO:0006699)4.53486314
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.50599325
19positive thymic T cell selection (GO:0045059)4.50429275
20regulation of gamma-delta T cell activation (GO:0046643)4.49604196
21tryptophan catabolic process (GO:0006569)4.47740079
22indole-containing compound catabolic process (GO:0042436)4.47740079
23indolalkylamine catabolic process (GO:0046218)4.47740079
24alpha-linolenic acid metabolic process (GO:0036109)4.38098682
25tolerance induction (GO:0002507)4.35587720
26kynurenine metabolic process (GO:0070189)4.32417309
27T cell selection (GO:0045058)4.32253840
28T cell migration (GO:0072678)4.23673422
29tryptophan metabolic process (GO:0006568)4.21504000
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.20354497
31interferon-gamma production (GO:0032609)4.19462121
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17123086
33antigen processing and presentation of endogenous antigen (GO:0019883)4.16156710
34high-density lipoprotein particle remodeling (GO:0034375)4.15829178
35thymic T cell selection (GO:0045061)4.13340988
36nitrogen cycle metabolic process (GO:0071941)4.11700879
37response to interleukin-15 (GO:0070672)4.08112572
38bile acid metabolic process (GO:0008206)4.03161158
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02786019
40negative regulation of fibrinolysis (GO:0051918)3.99776361
41complement activation, alternative pathway (GO:0006957)3.99735497
42regulation of fibrinolysis (GO:0051917)3.98879847
43regulation of protein activation cascade (GO:2000257)3.98728894
44peptidyl-glutamic acid carboxylation (GO:0017187)3.97331538
45protein carboxylation (GO:0018214)3.97331538
46cellular response to interleukin-15 (GO:0071350)3.87502339
47cysteine metabolic process (GO:0006534)3.85251413
48phospholipid efflux (GO:0033700)3.77367734
49regulation of triglyceride catabolic process (GO:0010896)3.76973154
50glyoxylate metabolic process (GO:0046487)3.76635773
51regulation of isotype switching to IgG isotypes (GO:0048302)3.73991561
52bile acid and bile salt transport (GO:0015721)3.70251946
53regulation of complement activation (GO:0030449)3.69863333
54intestinal cholesterol absorption (GO:0030299)3.69751049
55cellular extravasation (GO:0045123)3.68492937
56reverse cholesterol transport (GO:0043691)3.67484468
57negative regulation of T cell mediated immunity (GO:0002710)3.66902253
58glutamate metabolic process (GO:0006536)3.65599999
59triglyceride homeostasis (GO:0070328)3.65576675
60acylglycerol homeostasis (GO:0055090)3.65576675
61cellular ketone body metabolic process (GO:0046950)3.65537600
62negative regulation of cholesterol transport (GO:0032375)3.64836514
63negative regulation of sterol transport (GO:0032372)3.64836514
64cholesterol efflux (GO:0033344)3.63742784
65regulation of cholesterol esterification (GO:0010872)3.63219623
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.62628874
67protein-lipid complex remodeling (GO:0034368)3.59049599
68macromolecular complex remodeling (GO:0034367)3.59049599
69plasma lipoprotein particle remodeling (GO:0034369)3.59049599
70aromatic amino acid family metabolic process (GO:0009072)3.57009483
71leukocyte aggregation (GO:0070486)3.54051191
72homocysteine metabolic process (GO:0050667)3.53976784
73dicarboxylic acid biosynthetic process (GO:0043650)3.53496486
74sulfur amino acid catabolic process (GO:0000098)3.52678484
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49342852
76tyrosine metabolic process (GO:0006570)3.48146190
77drug catabolic process (GO:0042737)3.43661366
78positive regulation of granulocyte differentiation (GO:0030854)3.40053788
79regulation of cholesterol homeostasis (GO:2000188)3.39511488
80cellular response to ethanol (GO:0071361)3.39366537
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.39179975
82regulation of regulatory T cell differentiation (GO:0045589)3.37220045
83plasma lipoprotein particle assembly (GO:0034377)3.35792966
84regulation of T cell tolerance induction (GO:0002664)3.34969582
85indolalkylamine metabolic process (GO:0006586)3.33322316
86coenzyme catabolic process (GO:0009109)3.31728585
87alpha-amino acid catabolic process (GO:1901606)3.24942942
88serine family amino acid catabolic process (GO:0009071)3.24813749
89cytolysis (GO:0019835)3.24337306
90negative regulation of interleukin-12 production (GO:0032695)3.24255159
91cellular glucuronidation (GO:0052695)3.22208640
92regulation of bile acid biosynthetic process (GO:0070857)3.20449687
93regulation of interleukin-2 biosynthetic process (GO:0045076)3.17759987
94positive regulation by symbiont of host defense response (GO:0052509)3.17402074
95modulation by symbiont of host defense response (GO:0052031)3.17402074
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.17402074
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.17402074
98positive regulation by organism of defense response of other organism involved in symbiotic interact3.17402074
99modulation by symbiont of host immune response (GO:0052553)3.17402074
100B cell receptor signaling pathway (GO:0050853)3.15208120
101lysine metabolic process (GO:0006553)3.14378799
102lysine catabolic process (GO:0006554)3.14378799
103phospholipid homeostasis (GO:0055091)3.13115166
104plasma lipoprotein particle clearance (GO:0034381)3.13062501
105regulation of alpha-beta T cell proliferation (GO:0046640)3.10634904
106ketone body metabolic process (GO:1902224)3.10410247
107very-low-density lipoprotein particle assembly (GO:0034379)3.07278902
108macrophage activation involved in immune response (GO:0002281)3.07159891
109regulation of tolerance induction (GO:0002643)3.05618729
110negative regulation of lipase activity (GO:0060192)3.05346613
111negative regulation of leukocyte mediated immunity (GO:0002704)3.03968207
112positive regulation of lipid catabolic process (GO:0050996)3.01659263
113detection of other organism (GO:0098543)3.01636085
114T cell receptor signaling pathway (GO:0050852)3.00737007
115antigen receptor-mediated signaling pathway (GO:0050851)3.00328303
116cellular amino acid catabolic process (GO:0009063)2.99482482
117alpha-beta T cell differentiation (GO:0046632)2.98505197
118cellular modified amino acid catabolic process (GO:0042219)2.97742131
119cholesterol homeostasis (GO:0042632)2.97642349
120amino-acid betaine metabolic process (GO:0006577)2.97397423
121regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97347603
122sterol homeostasis (GO:0055092)2.95979689
123protein-lipid complex assembly (GO:0065005)2.94613242
124positive regulation of tolerance induction (GO:0002645)2.94124088
125microglial cell activation (GO:0001774)2.93823376
126benzene-containing compound metabolic process (GO:0042537)2.90919069
127antigen processing and presentation via MHC class Ib (GO:0002475)2.89227185
128intestinal absorption (GO:0050892)2.88626246
129flavonoid metabolic process (GO:0009812)2.88083352
130negative regulation of cell killing (GO:0031342)2.87660375
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87660375
132mast cell activation (GO:0045576)2.86957251
133CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86750755
134T-helper cell differentiation (GO:0042093)2.86750755
135positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86356713
136alpha-beta T cell activation (GO:0046631)2.86174070
137positive regulation of fatty acid beta-oxidation (GO:0032000)2.85625607
138low-density lipoprotein particle remodeling (GO:0034374)2.85082991
139indole-containing compound metabolic process (GO:0042430)2.82851986
140cellular biogenic amine catabolic process (GO:0042402)2.82820603
141amine catabolic process (GO:0009310)2.82820603
142germinal center formation (GO:0002467)2.82661421
143glucuronate metabolic process (GO:0019585)2.82290382
144uronic acid metabolic process (GO:0006063)2.82290382
145negative regulation of protein activation cascade (GO:2000258)2.81647788
146regulation of B cell differentiation (GO:0045577)2.80130997
147imidazole-containing compound metabolic process (GO:0052803)2.80113616
148lipoprotein metabolic process (GO:0042157)2.79894589
149detection of bacterium (GO:0016045)2.79063652
150regulation of natural killer cell mediated immunity (GO:0002715)2.77672518
151regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77672518
152nucleobase catabolic process (GO:0046113)2.77054643
153fibrinolysis (GO:0042730)2.75944605
154plasma lipoprotein particle organization (GO:0071827)2.74835544
155regulation of T cell mediated cytotoxicity (GO:0001914)2.74382506
156response to muramyl dipeptide (GO:0032495)2.74347793
157positive regulation of B cell differentiation (GO:0045579)2.72029622
158myeloid cell activation involved in immune response (GO:0002275)2.71450982
159arginine metabolic process (GO:0006525)2.69843197
160pyrimidine nucleobase catabolic process (GO:0006208)2.69313264
161opsonization (GO:0008228)2.67349532
162exogenous drug catabolic process (GO:0042738)2.67103112
163drug transmembrane transport (GO:0006855)2.64154638
164negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.63568136
165lipid homeostasis (GO:0055088)2.63507440
166CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.63357476
167short-chain fatty acid metabolic process (GO:0046459)2.63112847
168macrophage activation (GO:0042116)2.62958519
169positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.62660949
170negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61445697
171T cell proliferation (GO:0042098)2.60994080
172B cell homeostasis (GO:0001782)2.60845624
173alpha-beta T cell differentiation involved in immune response (GO:0002293)2.60300233
174alpha-beta T cell activation involved in immune response (GO:0002287)2.60300233
175T cell differentiation involved in immune response (GO:0002292)2.60300233
176sterol transport (GO:0015918)2.59707513
177cholesterol transport (GO:0030301)2.59707513
178positive regulation of Rap GTPase activity (GO:0032854)2.55344902
179positive regulation of interleukin-2 production (GO:0032743)2.54703069
180lymphocyte migration (GO:0072676)2.52328911
181dendritic cell migration (GO:0036336)2.51955643
182T cell homeostasis (GO:0043029)2.51750943
183hepatocyte apoptotic process (GO:0097284)2.51612024
184regulation of leukocyte mediated cytotoxicity (GO:0001910)2.51471584
185detection of external biotic stimulus (GO:0098581)2.51148040
186regulation of alpha-beta T cell activation (GO:0046634)2.50572148
187T cell costimulation (GO:0031295)2.49976398
188regulation of granulocyte differentiation (GO:0030852)2.49571887
189neutrophil activation involved in immune response (GO:0002283)2.49026101
190positive regulation of antigen processing and presentation (GO:0002579)2.48288127
191lymphocyte costimulation (GO:0031294)2.45828768
192negative regulation of innate immune response (GO:0045824)2.44186728
193regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43687392
194myeloid dendritic cell activation (GO:0001773)2.43520165
195negative regulation of adaptive immune response (GO:0002820)2.42041373
196respiratory burst (GO:0045730)2.41579533
197T cell differentiation (GO:0030217)2.41545343
198positive regulation of mast cell activation (GO:0033005)2.40887449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.93448670
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.59188937
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.31183313
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.68688375
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60122229
6RUNX_20019798_ChIP-Seq_JUKART_Human3.58024873
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.28103163
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13629642
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.91464794
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.76954996
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64625412
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.64038994
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61987221
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.60011376
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.54418112
16GBX2_23144817_ChIP-Seq_PC3_Human2.37799311
17* MYB_26560356_Chip-Seq_TH2_Human2.37152198
18EZH2_22144423_ChIP-Seq_EOC_Human2.37145720
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13350376
20SCL_19346495_ChIP-Seq_HPC-7_Human2.12767962
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09463449
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.07264728
23TAF15_26573619_Chip-Seq_HEK293_Human2.07170937
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01325338
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97866546
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95104190
27GATA3_27048872_Chip-Seq_THYMUS_Human1.88450781
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86296630
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83927496
30MYB_26560356_Chip-Seq_TH1_Human1.83912476
31AR_21572438_ChIP-Seq_LNCaP_Human1.82748453
32VDR_24787735_ChIP-Seq_THP-1_Human1.80482607
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78919752
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77386973
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70951611
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69719868
37DROSHA_22980978_ChIP-Seq_HELA_Human1.64213591
38SPI1_23127762_ChIP-Seq_K562_Human1.63700928
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62943216
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61531578
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55317342
42GATA3_26560356_Chip-Seq_TH2_Human1.53716832
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52759120
44* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50673063
45MAF_26560356_Chip-Seq_TH1_Human1.50130078
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49308940
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48289116
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45427193
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43363759
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41720329
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.41493339
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41466316
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41260172
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41260172
55* RARB_27405468_Chip-Seq_BRAIN_Mouse1.40814120
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.40417955
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39171451
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35884314
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35582396
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34475543
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.33146320
62GATA1_22025678_ChIP-Seq_K562_Human1.33031064
63REST_21632747_ChIP-Seq_MESCs_Mouse1.32857568
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31442814
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31275779
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30300244
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29125379
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.27662802
69SPI1_23547873_ChIP-Seq_NB4_Human1.27181885
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26876039
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25295367
72PU_27001747_Chip-Seq_BMDM_Mouse1.25294620
73* BCAT_22108803_ChIP-Seq_LS180_Human1.23001677
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22955504
75UTX_26944678_Chip-Seq_JUKART_Human1.22811577
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22383117
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22162337
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20493303
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20416879
80P300_19829295_ChIP-Seq_ESCs_Human1.20052150
81* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19143868
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18272773
83VDR_24763502_ChIP-Seq_THP-1_Human1.16400382
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15565757
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15537440
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15149019
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14847789
88AHR_22903824_ChIP-Seq_MCF-7_Human1.14623754
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14441583
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13980636
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12104766
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.11928455
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11161031
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.11126981
95* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10965700
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10848386
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09243195
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09059290
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09040332
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08899930
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08692769
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08173996
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08148475
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.07443524
105* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06659410
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.06030539
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.05649089
108STAT3_23295773_ChIP-Seq_U87_Human1.05432829
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05363375
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05182300
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02934506
112HTT_18923047_ChIP-ChIP_STHdh_Human1.02623292
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.02415149
114SMRT_27268052_Chip-Seq_Bcells_Human1.02347390
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02098307
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01238730
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00814599
118TP53_18474530_ChIP-ChIP_U2OS_Human1.00335801
119TCF7_22412390_ChIP-Seq_EML_Mouse1.00173743
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99968698
121REST_18959480_ChIP-ChIP_MESCs_Mouse0.99700727
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.99058119
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.98993354
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.98922149
125* MAF_26560356_Chip-Seq_TH2_Human0.98439356
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97931631
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97322783
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97322783
129AR_25329375_ChIP-Seq_VCAP_Human0.96935946
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95322223
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94829482
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94802681
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.94714438
134GATA1_19941826_ChIP-Seq_K562_Human0.93772226
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.92635373
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92538506
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.92280810
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91958944
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.91586563
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90211113
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89881612
142RNF2_27304074_Chip-Seq_ESCs_Mouse0.89300828
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.88802991
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88630724
145HNF4A_19822575_ChIP-Seq_HepG2_Human0.88299356
146CLOCK_20551151_ChIP-Seq_293T_Human0.88240202
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87914544
148IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87874710
149AR_19668381_ChIP-Seq_PC3_Human0.87599730
150KDM2B_26808549_Chip-Seq_DND41_Human0.87022504
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86843023
152TP53_16413492_ChIP-PET_HCT116_Human0.86123300
153TCF4_23295773_ChIP-Seq_U87_Human0.85906134
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85173130
155GATA2_19941826_ChIP-Seq_K562_Human0.84954519
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.83294701
157RUNX2_22187159_ChIP-Seq_PCA_Human0.83161756
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.82934706
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82835848
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.82121710
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82076804
162RXR_22108803_ChIP-Seq_LS180_Human0.82072129
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.81323467
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.81131140
165KDM2B_26808549_Chip-Seq_REH_Human0.81004725
166P53_22387025_ChIP-Seq_ESCs_Mouse0.80738369
167WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80473981
168FOXO3_23340844_ChIP-Seq_DLD1_Human0.80285010
169IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80029755
170ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79251150
171KDM2B_26808549_Chip-Seq_JURKAT_Human0.79227066
172AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78682646
173SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78643027
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.76965303
175SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75808964
176KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75472484
177NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75299968
178MYC_22102868_ChIP-Seq_BL_Human0.74736072
179TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74466021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.81241364
2MP0002139_abnormal_hepatobiliary_system6.67874753
3MP0005085_abnormal_gallbladder_physiolo5.70338895
4MP0005365_abnormal_bile_salt5.28247611
5MP0002822_catalepsy4.20442970
6MP0008875_abnormal_xenobiotic_pharmacok3.84475858
7MP0003252_abnormal_bile_duct3.61260735
8MP0003763_abnormal_thymus_physiology3.61192342
9MP0005671_abnormal_response_to3.45364257
10MP0000569_abnormal_digit_pigmentation3.40923232
11MP0003724_increased_susceptibility_to3.29755665
12MP0010329_abnormal_lipoprotein_level3.24121518
13MP0001835_abnormal_antigen_presentation3.16735079
14MP0001666_abnormal_nutrient_absorption2.89848524
15MP0001800_abnormal_humoral_immune2.70396294
16MP0003436_decreased_susceptibility_to2.61561766
17MP0000685_abnormal_immune_system2.58505409
18MP0005083_abnormal_biliary_tract2.54098401
19MP0005387_immune_system_phenotype2.51640258
20MP0001790_abnormal_immune_system2.51640258
21MP0005000_abnormal_immune_tolerance2.40841952
22MP0003303_peritoneal_inflammation2.40725079
23MP0002723_abnormal_immune_serum2.29209141
24MP0006082_CNS_inflammation2.24851797
25MP0002452_abnormal_antigen_presenting2.20393065
26MP0002420_abnormal_adaptive_immunity2.19605575
27MP0001819_abnormal_immune_cell2.16527986
28MP0002419_abnormal_innate_immunity2.15245077
29MP0005025_abnormal_response_to2.14933127
30MP0004859_abnormal_synaptic_plasticity2.10506803
31MP0009333_abnormal_splenocyte_physiolog2.01734483
32MP0005332_abnormal_amino_acid2.00732084
33MP0002009_preneoplasia1.97696963
34MP0003172_abnormal_lysosome_physiology1.97364809
35MP0009780_abnormal_chondrocyte_physiolo1.91647205
36MP0002405_respiratory_system_inflammati1.85482791
37MP0005310_abnormal_salivary_gland1.85304967
38MP0009785_altered_susceptibility_to1.84378886
39MP0003868_abnormal_feces_composition1.83488496
40MP0002118_abnormal_lipid_homeostasis1.82568409
41MP0002148_abnormal_hypersensitivity_rea1.78466094
42MP0003195_calcinosis1.76192807
43MP0003806_abnormal_nucleotide_metabolis1.74401765
44MP0009840_abnormal_foam_cell1.70906309
45MP0000465_gastrointestinal_hemorrhage1.69860005
46MP0000716_abnormal_immune_system1.68903653
47MP0002166_altered_tumor_susceptibility1.68744515
48MP0000609_abnormal_liver_physiology1.66834341
49MP0002138_abnormal_hepatobiliary_system1.65383665
50MP0010234_abnormal_vibrissa_follicle1.64978534
51MP0002398_abnormal_bone_marrow1.64594664
52MP0010155_abnormal_intestine_physiology1.58725148
53MP0003635_abnormal_synaptic_transmissio1.57342638
54MP0000015_abnormal_ear_pigmentation1.52770084
55MP0001851_eye_inflammation1.51670604
56MP0009745_abnormal_behavioral_response1.51157721
57MP0001845_abnormal_inflammatory_respons1.50045195
58MP0000703_abnormal_thymus_morphology1.47476097
59MP0001873_stomach_inflammation1.47351994
60MP0000689_abnormal_spleen_morphology1.46228550
61MP0005464_abnormal_platelet_physiology1.44967525
62MP0004381_abnormal_hair_follicle1.41979320
63MP0003828_pulmonary_edema1.41137378
64MP0002063_abnormal_learning/memory/cond1.40433181
65MP0002909_abnormal_adrenal_gland1.39132019
66MP0003191_abnormal_cellular_cholesterol1.38139553
67MP0001533_abnormal_skeleton_physiology1.36347530
68MP0003880_abnormal_central_pattern1.35871519
69MP0002722_abnormal_immune_system1.33050356
70MP0004019_abnormal_vitamin_homeostasis1.32213485
71MP0002638_abnormal_pupillary_reflex1.31085298
72MP0002876_abnormal_thyroid_physiology1.30496593
73MP0004947_skin_inflammation1.29801867
74MP0002998_abnormal_bone_remodeling1.29500399
75MP0003300_gastrointestinal_ulcer1.25691336
76MP0001501_abnormal_sleep_pattern1.24184238
77MP0002933_joint_inflammation1.23485261
78MP0003787_abnormal_imprinting1.22183153
79MP0005535_abnormal_body_temperature1.21868469
80MP0009697_abnormal_copulation1.21710405
81MP0005058_abnormal_lysosome_morphology1.21007111
82MP0005584_abnormal_enzyme/coenzyme_acti1.20994022
83MP0002429_abnormal_blood_cell1.20263911
84MP0000604_amyloidosis1.20072195
85MP0002572_abnormal_emotion/affect_behav1.19495445
86MP0004270_analgesia1.18599210
87MP0002396_abnormal_hematopoietic_system1.15224926
88MP0005174_abnormal_tail_pigmentation1.14755434
89MP0004510_myositis1.13599581
90MP0005084_abnormal_gallbladder_morpholo1.12014969
91MP0003329_amyloid_beta_deposits1.11322616
92MP0005448_abnormal_energy_balance1.09730357
93MP0005075_abnormal_melanosome_morpholog1.08154880
94MP0008961_abnormal_basal_metabolism1.05074458
95MP0001486_abnormal_startle_reflex1.04558741
96MP0002254_reproductive_system_inflammat1.03507789
97MP0002064_seizures1.02314415
98MP0002078_abnormal_glucose_homeostasis1.01589537
99MP0005319_abnormal_enzyme/_coenzyme1.00521877
100MP0001764_abnormal_homeostasis0.97747246
101MP0001853_heart_inflammation0.97692218
102MP0008057_abnormal_DNA_replication0.94500992
103MP0008469_abnormal_protein_level0.93110830
104MP0008872_abnormal_physiological_respon0.92754017
105MP0003183_abnormal_peptide_metabolism0.92367797
106MP0005386_behavior/neurological_phenoty0.91210178
107MP0004924_abnormal_behavior0.91210178
108MP0008874_decreased_physiological_sensi0.90349939
109MP0002006_tumorigenesis0.89221893
110MP0005646_abnormal_pituitary_gland0.87922813
111MP0000013_abnormal_adipose_tissue0.87522298
112MP0004883_abnormal_blood_vessel0.86522090
113MP0003705_abnormal_hypodermis_morpholog0.84327322
114MP0009643_abnormal_urine_homeostasis0.84143026
115MP0004484_altered_response_of0.83784310
116MP0002837_dystrophic_cardiac_calcinosis0.83518109
117MP0001986_abnormal_taste_sensitivity0.83424411
118MP0001177_atelectasis0.82296419
119MP0002163_abnormal_gland_morphology0.80551341
120MP0001440_abnormal_grooming_behavior0.79170677
121MP0001968_abnormal_touch/_nociception0.78389029
122MP0005379_endocrine/exocrine_gland_phen0.78216273
123MP0002272_abnormal_nervous_system0.76981851
124MP0000371_diluted_coat_color0.76969901
125MP0008569_lethality_at_weaning0.76199309
126MP0003879_abnormal_hair_cell0.76130001
127MP0002277_abnormal_respiratory_mucosa0.75902482
128MP0002971_abnormal_brown_adipose0.73517917
129MP0004043_abnormal_pH_regulation0.73495145
130MP0008260_abnormal_autophagy0.73273845
131MP0006276_abnormal_autonomic_nervous0.73093617
132MP0009642_abnormal_blood_homeostasis0.72983921
133MP0005220_abnormal_exocrine_pancreas0.71917096
134MP0000920_abnormal_myelination0.71890807
135MP0004130_abnormal_muscle_cell0.71878968
136MP0000249_abnormal_blood_vessel0.70447026
137MP0001663_abnormal_digestive_system0.70313649
138MP0005334_abnormal_fat_pad0.69813705
139MP0005636_abnormal_mineral_homeostasis0.68859142
140MP0008877_abnormal_DNA_methylation0.67585084
141MP0009765_abnormal_xenobiotic_induced0.67579431
142MP0009046_muscle_twitch0.67308851
143MP0003633_abnormal_nervous_system0.67191624
144MP0002557_abnormal_social/conspecific_i0.66811638
145MP0002069_abnormal_eating/drinking_beha0.66650937
146MP0009278_abnormal_bone_marrow0.66618940
147MP0010368_abnormal_lymphatic_system0.66295822
148MP0004808_abnormal_hematopoietic_stem0.65870532
149MP0001944_abnormal_pancreas_morphology0.64379131
150MP0009764_decreased_sensitivity_to0.63891479
151MP0004142_abnormal_muscle_tone0.63536697
152MP0002693_abnormal_pancreas_physiology0.62685371
153MP0000230_abnormal_systemic_arterial0.62280469
154MP0003959_abnormal_lean_body0.62256972
155MP0003953_abnormal_hormone_level0.62194087
156MP0001529_abnormal_vocalization0.62032613
157MP0005451_abnormal_body_composition0.60957309
158MP0003091_abnormal_cell_migration0.60595345
159MP0009115_abnormal_fat_cell0.59919758
160MP0000598_abnormal_liver_morphology0.59882762
161MP0003656_abnormal_erythrocyte_physiolo0.58939997
162MP0005647_abnormal_sex_gland0.58546297
163MP0005166_decreased_susceptibility_to0.58006755
164MP0009384_cardiac_valve_regurgitation0.57757716
165MP0002928_abnormal_bile_duct0.57704846
166MP0009763_increased_sensitivity_to0.57067312
167MP0003690_abnormal_glial_cell0.56565435
168MP0003866_abnormal_defecation0.55879314
169MP0001756_abnormal_urination0.55738017
170MP0005397_hematopoietic_system_phenotyp0.55639460
171MP0001545_abnormal_hematopoietic_system0.55639460
172MP0001502_abnormal_circadian_rhythm0.55629386
173MP0003632_abnormal_nervous_system0.55558033
174MP0001765_abnormal_ion_homeostasis0.55257280
175MP0003045_fibrosis0.54742783
176MP0001984_abnormal_olfaction0.53705381
177MP0000639_abnormal_adrenal_gland0.52838998
178MP0005187_abnormal_penis_morphology0.52615136
179MP0002734_abnormal_mechanical_nocicepti0.51337940
180MP0002733_abnormal_thermal_nociception0.50780559
181MP0001661_extended_life_span0.49473300
182MP0006035_abnormal_mitochondrial_morpho0.49060953

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.12397971
2Deep venous thrombosis (HP:0002625)6.06782287
3Hypobetalipoproteinemia (HP:0003563)5.93244809
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.76038645
5Prolonged partial thromboplastin time (HP:0003645)5.45012067
6Xanthomatosis (HP:0000991)5.34499742
7Eczematoid dermatitis (HP:0000976)5.33509980
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.14134275
9T lymphocytopenia (HP:0005403)5.01712016
10Conjugated hyperbilirubinemia (HP:0002908)4.76850543
11Abnormality of T cell number (HP:0011839)4.75156425
12Recurrent bacterial skin infections (HP:0005406)4.52883149
13Complement deficiency (HP:0004431)4.40326545
14Stomatitis (HP:0010280)4.28879829
15Epidermoid cyst (HP:0200040)4.27953532
16Hyperlipoproteinemia (HP:0010980)4.18235546
17Abnormality of the common coagulation pathway (HP:0010990)4.15060069
18Recurrent abscess formation (HP:0002722)4.08449557
19Hypolipoproteinemia (HP:0010981)4.04087555
20Fat malabsorption (HP:0002630)3.92645967
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.76519333
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.62230694
23Ketosis (HP:0001946)3.60615091
24Recurrent fungal infections (HP:0002841)3.60084907
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.54373227
26Abnormality of glycolipid metabolism (HP:0010969)3.54373227
27Abnormality of liposaccharide metabolism (HP:0010968)3.54373227
28Acanthocytosis (HP:0001927)3.52283284
29Myositis (HP:0100614)3.51631147
30Joint hemorrhage (HP:0005261)3.46369001
31Abnormality of macrophages (HP:0004311)3.41762269
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.41155265
33Optic neuritis (HP:0100653)3.37202494
34Retrobulbar optic neuritis (HP:0100654)3.37202494
35Spontaneous hematomas (HP:0007420)3.35114389
36Elevated erythrocyte sedimentation rate (HP:0003565)3.31291602
37Abnormality of T cells (HP:0002843)3.30924499
38Hypoglycemic coma (HP:0001325)3.25435480
39Recurrent cutaneous fungal infections (HP:0011370)3.21780794
40Chronic mucocutaneous candidiasis (HP:0002728)3.21780794
41Abnormality of the intrinsic pathway (HP:0010989)3.20731355
42Pustule (HP:0200039)3.17764274
43Mediastinal lymphadenopathy (HP:0100721)3.15995380
44Hypercholesterolemia (HP:0003124)3.14582194
45Orchitis (HP:0100796)3.13385287
46Hyperammonemia (HP:0001987)3.12504577
47Recurrent skin infections (HP:0001581)3.06613843
48Hyperglycinemia (HP:0002154)3.06477390
49Abnormality of sulfur amino acid metabolism (HP:0004339)3.05738375
50Hypoalphalipoproteinemia (HP:0003233)3.05123912
51Abnormality of aspartate family amino acid metabolism (HP:0010899)3.03806801
52Abnormality of complement system (HP:0005339)2.91757004
53Recurrent gram-negative bacterial infections (HP:0005420)2.88616520
54Ketoacidosis (HP:0001993)2.87533918
55Autoimmune hemolytic anemia (HP:0001890)2.86912244
56Skin nodule (HP:0200036)2.84935123
57Increased cerebral lipofuscin (HP:0011813)2.84222516
58Chronic diarrhea (HP:0002028)2.78291896
59Autoimmune thrombocytopenia (HP:0001973)2.75414390
60Hypoglycemic seizures (HP:0002173)2.74037118
61Abnormality of methionine metabolism (HP:0010901)2.73799009
62Meningitis (HP:0001287)2.73699365
63Gastrointestinal infarctions (HP:0005244)2.73522865
64Pulmonary infiltrates (HP:0002113)2.72703100
65Vasculitis (HP:0002633)2.68228063
66Hypochromic microcytic anemia (HP:0004840)2.66826814
67Myokymia (HP:0002411)2.65476327
68Hyperbilirubinemia (HP:0002904)2.65228395
69Abnormality of glycine metabolism (HP:0010895)2.64798332
70Abnormality of serine family amino acid metabolism (HP:0010894)2.64798332
71Spontaneous abortion (HP:0005268)2.64571962
72Delayed CNS myelination (HP:0002188)2.62723547
73Hyperglycinuria (HP:0003108)2.62663723
74Papilledema (HP:0001085)2.61924179
75Hemoptysis (HP:0002105)2.61905447
76Hematochezia (HP:0002573)2.59208008
77Encephalitis (HP:0002383)2.56860878
78Hyperventilation (HP:0002883)2.56414330
79Dysostosis multiplex (HP:0000943)2.53743156
80Recurrent viral infections (HP:0004429)2.53721183
81Focal motor seizures (HP:0011153)2.48597325
82Gingivitis (HP:0000230)2.47662122
83Leukocytosis (HP:0001974)2.45817263
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.45786122
85Global brain atrophy (HP:0002283)2.44339120
86Panhypogammaglobulinemia (HP:0003139)2.43303310
87Hepatocellular carcinoma (HP:0001402)2.43133968
88Chest pain (HP:0100749)2.42827532
89Sensorimotor neuropathy (HP:0007141)2.41010920
90Keratoconjunctivitis (HP:0001096)2.39137770
91Hemiplegia (HP:0002301)2.38880787
92Abnormality of eosinophils (HP:0001879)2.38167994
93Keratoconjunctivitis sicca (HP:0001097)2.37539260
94Myocardial infarction (HP:0001658)2.34820538
95Severe combined immunodeficiency (HP:0004430)2.34796509
96Steatorrhea (HP:0002570)2.34411305
97Recurrent bronchitis (HP:0002837)2.33921209
98Fair hair (HP:0002286)2.32844663
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30488827
100Gout (HP:0001997)2.30343971
101Obstructive lung disease (HP:0006536)2.28871226
102Chronic obstructive pulmonary disease (HP:0006510)2.28871226
103Hyperinsulinemic hypoglycemia (HP:0000825)2.24704051
104Abnormality of T cell physiology (HP:0011840)2.22054861
105IgM deficiency (HP:0002850)2.21612392
106Abnormality of purine metabolism (HP:0004352)2.21432381
107Eosinophilia (HP:0001880)2.21401729
108Decreased circulating renin level (HP:0003351)2.20419822
109Torticollis (HP:0000473)2.19610312
110IgG deficiency (HP:0004315)2.18352828
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17069818
112Scanning speech (HP:0002168)2.16689223
113Status epilepticus (HP:0002133)2.16125634
114Symptomatic seizures (HP:0011145)2.15942089
115Ocular albinism (HP:0001107)2.15768108
116Limb hypertonia (HP:0002509)2.14253088
117Mitral stenosis (HP:0001718)2.14183186
118Metabolic acidosis (HP:0001942)2.13233808
119Urinary glycosaminoglycan excretion (HP:0003541)2.11586556
120Mucopolysacchariduria (HP:0008155)2.11586556
121Abnormality of nucleobase metabolism (HP:0010932)2.11379305
122Inflammation of the large intestine (HP:0002037)2.10440570
123Vacuolated lymphocytes (HP:0001922)2.10299352
124Increased CSF protein (HP:0002922)2.10010544
125Focal seizures (HP:0007359)2.09068393
126Abnormality of polysaccharide metabolism (HP:0011012)2.07459839
127Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07459839
128Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07459839
129Disinhibition (HP:0000734)2.07095934
130Dysmetric saccades (HP:0000641)2.06578919
131Neonatal onset (HP:0003623)2.06314553
132Subacute progressive viral hepatitis (HP:0006572)2.06029895
133Abnormal gallbladder morphology (HP:0012437)2.05006175
134Prolonged bleeding time (HP:0003010)2.04636359
135Combined immunodeficiency (HP:0005387)2.04423842
136Neoplasm of the tracheobronchial system (HP:0100552)2.04189174
137Arterial thrombosis (HP:0004420)2.04173030
138Granulocytopenia (HP:0001913)2.03417589
139Thyroiditis (HP:0100646)2.03287584
140Abnormal gallbladder physiology (HP:0012438)2.02768264
141Cholecystitis (HP:0001082)2.02768264
142Gingival bleeding (HP:0000225)2.02320379
143Hyperglycemia (HP:0003074)2.01064534
144Abnormal social behavior (HP:0012433)2.00552003
145Impaired social interactions (HP:0000735)2.00552003
146Craniofacial dystonia (HP:0012179)2.00527484
147Abnormality of the fingertips (HP:0001211)2.00493252
148Poikilocytosis (HP:0004447)2.00447423
149Loss of speech (HP:0002371)2.00061683
150Slow saccadic eye movements (HP:0000514)1.99892553
151Irritability (HP:0000737)1.97400251
152Pancreatitis (HP:0001733)1.97307313
153Vascular calcification (HP:0004934)1.96828668
154Hypophosphatemic rickets (HP:0004912)1.94897670
155Cerebral inclusion bodies (HP:0100314)1.93155187
156Epistaxis (HP:0000421)1.92562824
157Focal dystonia (HP:0004373)1.91443148
158Abnormality of pyrimidine metabolism (HP:0004353)1.91273152
159Acute hepatic failure (HP:0006554)1.90955707
160Joint swelling (HP:0001386)1.90473289
161Abnormality of fatty-acid metabolism (HP:0004359)1.90384473
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90355647
163Urticaria (HP:0001025)1.89925126
164Malnutrition (HP:0004395)1.89131314
165Amyloidosis (HP:0011034)1.88823248
166Abnormality of the prostate (HP:0008775)1.88537044
167Esophageal varix (HP:0002040)1.88522971
168Stomach cancer (HP:0012126)1.88435931
169Cholelithiasis (HP:0001081)1.88231739
170Gastrointestinal inflammation (HP:0004386)1.88042328
171Generalized hypopigmentation of hair (HP:0011358)1.85626621
172Pulmonary embolism (HP:0002204)1.83616334
173Anxiety (HP:0000739)1.83202250
174Colitis (HP:0002583)1.82687062
175Rickets (HP:0002748)1.82184026
176Late onset (HP:0003584)1.81252706
177Neurofibrillary tangles (HP:0002185)1.81206289
178Menorrhagia (HP:0000132)1.80984497
179Polyneuropathy (HP:0001271)1.79646968
180Iris hypopigmentation (HP:0007730)1.79491196
181Abnormality of the pleura (HP:0002103)1.78262569
182Cardiovascular calcification (HP:0011915)1.78194537
183Thrombophlebitis (HP:0004418)1.77975932
184Increased IgM level (HP:0003496)1.75561819
185Alveolar cell carcinoma (HP:0006519)1.75345734
186Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74972112
187Enlarged kidneys (HP:0000105)1.74195586
188Dysdiadochokinesis (HP:0002075)1.73627213
189Albinism (HP:0001022)1.73478897
190Papilloma (HP:0012740)1.72935386
191Verrucae (HP:0200043)1.72935386
192Blue irides (HP:0000635)1.71098152
193Lymphopenia (HP:0001888)1.70999731
194Abnormality of proline metabolism (HP:0010907)1.70771684
195Hydroxyprolinuria (HP:0003080)1.70771684
196Glomerulonephritis (HP:0000099)1.69248643
197Death in childhood (HP:0003819)1.68884020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.85250718
2NTRK33.19638111
3FRK2.88359207
4FGFR42.67319301
5INSRR2.39636698
6PRPF4B2.34611384
7BLK2.28962220
8DAPK22.23262048
9SIK11.97869716
10MAP3K21.85174078
11ZAP701.84053658
12MAP3K91.82168502
13MAP2K41.81521333
14FGFR21.79051503
15IRAK41.66194281
16MAP3K41.63967611
17SIK21.59070994
18BTK1.53917746
19MARK11.48941245
20SYK1.48590062
21NTRK11.47481342
22ACVR1B1.46559962
23NTRK21.45854673
24HCK1.44648301
25GRK61.43384507
26KSR11.42013722
27RIPK11.41353479
28LCK1.41097274
29MAP3K131.39938211
30MINK11.39251731
31KSR21.39204257
32PIK3CG1.36708402
33TEC1.34057281
34FGFR31.32366541
35BCKDK1.32106925
36JAK11.28106975
37ITK1.23502334
38TAOK31.23317121
39CAMKK11.22441221
40PRKCH1.21070208
41MAP3K71.19132440
42SGK21.18626058
43MAP3K121.17309425
44RIPK41.13737284
45GRK71.12018076
46LYN1.10626328
47PRKCQ1.09020740
48PAK31.08374199
49SGK31.06235919
50MAP3K101.04724827
51MST1R1.04092355
52TAOK11.00505686
53PASK1.00159958
54MAPK120.99869210
55TXK0.98575549
56STK110.98494186
57CDK50.95940528
58IRAK10.95715661
59TGFBR20.94982479
60RET0.94743941
61MAP3K10.93884762
62FES0.92011810
63IKBKB0.91386040
64ERBB40.91111441
65CAMK40.90783471
66TNIK0.90666209
67CSF1R0.88812739
68EPHA30.88539940
69SGK2230.88113018
70SGK4940.88113018
71MAP2K70.87243601
72CASK0.86638168
73TNK20.85386858
74CAMKK20.84229195
75MARK30.82915331
76MAPK70.81437560
77DAPK10.80448720
78NUAK10.79212645
79BMPR20.78267969
80JAK20.77949081
81TRPM70.72794566
82YES10.72696009
83IKBKE0.72497802
84EPHB10.72493681
85JAK30.72299518
86STK380.72160668
87MAPK110.71863079
88PRKCZ0.71628667
89MARK20.70883285
90CAMK2A0.70752875
91MAP2K30.69837371
92TBK10.69667195
93PDGFRA0.69478424
94RAF10.68549222
95PRKCG0.68243858
96CAMK2B0.67943776
97CSK0.66511594
98PIM10.65908199
99PDK10.64664157
100LATS10.64598322
101FGR0.64560948
102BRD40.64477954
103TYRO30.63927705
104SGK10.63080956
105NLK0.61590358
106TYK20.60948132
107MAP2K10.59720159
108WNK10.58120502
109SIK30.57653929
110CAMK1D0.56021905
111ADRBK20.54845931
112PTK60.54755739
113CAMK1G0.54567423
114CDK60.54363432
115MAP4K10.54070052
116PRKACG0.53807450
117PDPK10.53273154
118PRKD30.53217183
119FER0.53198736
120KIT0.52948157
121FYN0.52766572
122ERBB20.52241145
123MAPK150.52086535
124PKN20.51831636
125CAMK10.51760203
126PAK60.51449929
127CDC42BPA0.51193614
128MAP3K60.50687268
129HIPK20.50401171
130PRKAA20.49833714
131MELK0.49436296
132LMTK20.49273494
133PRKCB0.49219362
134PDGFRB0.48699612
135RPS6KA30.47790264
136CHUK0.47664487
137ERN10.47279494
138DYRK1B0.46416355
139CSNK1G20.46413143
140UHMK10.46070029
141FGFR10.45855116
142MAP3K140.45724854
143PTK20.40707335
144IGF1R0.40374797
145MAP2K60.39950455
146PIK3CA0.39204425
147RPS6KA60.38132338
148IRAK20.37874936

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.09860155
2Nitrogen metabolism_Homo sapiens_hsa009103.91721064
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82125711
4Arginine biosynthesis_Homo sapiens_hsa002202.81088777
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73165535
6Tryptophan metabolism_Homo sapiens_hsa003802.44830193
7Graft-versus-host disease_Homo sapiens_hsa053322.30755751
8Osteoclast differentiation_Homo sapiens_hsa043802.23586680
9Butanoate metabolism_Homo sapiens_hsa006502.19415241
10Complement and coagulation cascades_Homo sapiens_hsa046102.18262646
11Allograft rejection_Homo sapiens_hsa053302.12838487
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12029526
13Autoimmune thyroid disease_Homo sapiens_hsa053202.10395156
14Primary immunodeficiency_Homo sapiens_hsa053402.05534652
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99824773
16Type I diabetes mellitus_Homo sapiens_hsa049401.96975201
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96097742
18Fatty acid degradation_Homo sapiens_hsa000711.92471661
19Leishmaniasis_Homo sapiens_hsa051401.92226916
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.90695627
21B cell receptor signaling pathway_Homo sapiens_hsa046621.84178695
22Bile secretion_Homo sapiens_hsa049761.81374071
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78395441
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78329404
25PPAR signaling pathway_Homo sapiens_hsa033201.69773218
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.69155870
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67195302
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.66227649
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58573990
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53105722
31Histidine metabolism_Homo sapiens_hsa003401.51937642
32Peroxisome_Homo sapiens_hsa041461.50879606
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48967167
34Measles_Homo sapiens_hsa051621.48785074
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48636370
36Tuberculosis_Homo sapiens_hsa051521.46642461
37Fat digestion and absorption_Homo sapiens_hsa049751.45609063
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45558183
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44559073
40Fatty acid metabolism_Homo sapiens_hsa012121.37580563
41Sulfur metabolism_Homo sapiens_hsa009201.36468244
42ABC transporters_Homo sapiens_hsa020101.35673286
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.35347933
44Chemokine signaling pathway_Homo sapiens_hsa040621.34818361
45Chemical carcinogenesis_Homo sapiens_hsa052041.34674672
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33538981
47beta-Alanine metabolism_Homo sapiens_hsa004101.31791152
48Propanoate metabolism_Homo sapiens_hsa006401.30958567
49Phenylalanine metabolism_Homo sapiens_hsa003601.29781773
50Antigen processing and presentation_Homo sapiens_hsa046121.29742400
51Rheumatoid arthritis_Homo sapiens_hsa053231.28584045
52Hematopoietic cell lineage_Homo sapiens_hsa046401.27065778
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25596232
54Caffeine metabolism_Homo sapiens_hsa002321.25457609
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25387582
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.24551287
57Other glycan degradation_Homo sapiens_hsa005111.24477407
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22256353
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22181861
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20926513
61Dorso-ventral axis formation_Homo sapiens_hsa043201.20213342
62Viral myocarditis_Homo sapiens_hsa054161.20188301
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20126797
64Toxoplasmosis_Homo sapiens_hsa051451.19628939
65Staphylococcus aureus infection_Homo sapiens_hsa051501.17598524
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17518796
67Lysosome_Homo sapiens_hsa041421.16684743
68Acute myeloid leukemia_Homo sapiens_hsa052211.15514395
69Non-small cell lung cancer_Homo sapiens_hsa052231.15323175
70Starch and sucrose metabolism_Homo sapiens_hsa005001.14881026
71TNF signaling pathway_Homo sapiens_hsa046681.13959345
72Retinol metabolism_Homo sapiens_hsa008301.10169717
73Platelet activation_Homo sapiens_hsa046111.09946927
74Tyrosine metabolism_Homo sapiens_hsa003501.07597567
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05290774
76Asthma_Homo sapiens_hsa053101.04510924
77Prolactin signaling pathway_Homo sapiens_hsa049171.03531295
78Inositol phosphate metabolism_Homo sapiens_hsa005621.00218907
79Cocaine addiction_Homo sapiens_hsa050301.00205164
80Amphetamine addiction_Homo sapiens_hsa050310.99506873
81Nicotine addiction_Homo sapiens_hsa050330.98234267
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96641184
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.95728448
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.94909538
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94294533
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93435477
87Influenza A_Homo sapiens_hsa051640.91711088
88Hepatitis B_Homo sapiens_hsa051610.90426319
89FoxO signaling pathway_Homo sapiens_hsa040680.89866262
90Circadian rhythm_Homo sapiens_hsa047100.88101862
91Glycerolipid metabolism_Homo sapiens_hsa005610.86659753
92VEGF signaling pathway_Homo sapiens_hsa043700.86179950
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.85449907
94Selenocompound metabolism_Homo sapiens_hsa004500.84994651
95Malaria_Homo sapiens_hsa051440.84621563
96Phagosome_Homo sapiens_hsa041450.83728542
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.83549527
98Pyruvate metabolism_Homo sapiens_hsa006200.82804550
99Olfactory transduction_Homo sapiens_hsa047400.82622600
100mTOR signaling pathway_Homo sapiens_hsa041500.82138335
101GABAergic synapse_Homo sapiens_hsa047270.82020065
102Renin secretion_Homo sapiens_hsa049240.81651340
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.80710742
104Legionellosis_Homo sapiens_hsa051340.80285247
105Fatty acid elongation_Homo sapiens_hsa000620.79583412
106Morphine addiction_Homo sapiens_hsa050320.77996060
107Long-term potentiation_Homo sapiens_hsa047200.77099202
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75613516
109Herpes simplex infection_Homo sapiens_hsa051680.74342365
110Renal cell carcinoma_Homo sapiens_hsa052110.73589366
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73509227
112Insulin secretion_Homo sapiens_hsa049110.69935774
113Pertussis_Homo sapiens_hsa051330.69623943
114Prion diseases_Homo sapiens_hsa050200.69222732
115Apoptosis_Homo sapiens_hsa042100.69190424
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68140808
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67971559
118Circadian entrainment_Homo sapiens_hsa047130.67795150
119Lysine degradation_Homo sapiens_hsa003100.67138144
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66705375
121Pancreatic cancer_Homo sapiens_hsa052120.66679660
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66316704
123Vitamin digestion and absorption_Homo sapiens_hsa049770.66017327
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65921740
125Type II diabetes mellitus_Homo sapiens_hsa049300.64965808
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64884026
127Glutamatergic synapse_Homo sapiens_hsa047240.63804854
128Dopaminergic synapse_Homo sapiens_hsa047280.63275566
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.63236781
130Salivary secretion_Homo sapiens_hsa049700.62953025
131Fatty acid biosynthesis_Homo sapiens_hsa000610.62850138
132Hepatitis C_Homo sapiens_hsa051600.62469488
133Choline metabolism in cancer_Homo sapiens_hsa052310.60562960
134Regulation of autophagy_Homo sapiens_hsa041400.60531536
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60226854
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59999998
137Collecting duct acid secretion_Homo sapiens_hsa049660.59843980
138MAPK signaling pathway_Homo sapiens_hsa040100.59740529
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58044967
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56657382
141Colorectal cancer_Homo sapiens_hsa052100.56415078
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.55552261
143Endometrial cancer_Homo sapiens_hsa052130.54256631
144Cholinergic synapse_Homo sapiens_hsa047250.53547823
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52936509
146HIF-1 signaling pathway_Homo sapiens_hsa040660.52756703
147Glucagon signaling pathway_Homo sapiens_hsa049220.51970936
148Ether lipid metabolism_Homo sapiens_hsa005650.49024194
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48936336
150Ras signaling pathway_Homo sapiens_hsa040140.48724315
151Chronic myeloid leukemia_Homo sapiens_hsa052200.47749784
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.47326135
153Insulin resistance_Homo sapiens_hsa049310.44883238
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44222323
155Biosynthesis of amino acids_Homo sapiens_hsa012300.41488738
156Taste transduction_Homo sapiens_hsa047420.41154394
157Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40742556
158Carbon metabolism_Homo sapiens_hsa012000.40613864
159Steroid biosynthesis_Homo sapiens_hsa001000.40368509
160Gastric acid secretion_Homo sapiens_hsa049710.39660292
161Thyroid hormone synthesis_Homo sapiens_hsa049180.37911836
162Calcium signaling pathway_Homo sapiens_hsa040200.37376538
163Folate biosynthesis_Homo sapiens_hsa007900.36703794
164Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33663237
165T cell receptor signaling pathway_Homo sapiens_hsa046600.33458437
166Arginine and proline metabolism_Homo sapiens_hsa003300.31680402
167Adipocytokine signaling pathway_Homo sapiens_hsa049200.31189766
168cAMP signaling pathway_Homo sapiens_hsa040240.30718313
169Oxytocin signaling pathway_Homo sapiens_hsa049210.30269505
170Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29887066
171Synaptic vesicle cycle_Homo sapiens_hsa047210.28292625
172Serotonergic synapse_Homo sapiens_hsa047260.26718047
173GnRH signaling pathway_Homo sapiens_hsa049120.26657099
174Long-term depression_Homo sapiens_hsa047300.26471859
175Pancreatic secretion_Homo sapiens_hsa049720.25014421
176Estrogen signaling pathway_Homo sapiens_hsa049150.23866825
177Glycerophospholipid metabolism_Homo sapiens_hsa005640.23486750
178Gap junction_Homo sapiens_hsa045400.22567261
179Insulin signaling pathway_Homo sapiens_hsa049100.20333352

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