GPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cullin deneddylation (GO:0010388)4.90150474
2DNA deamination (GO:0045006)4.88717533
3formation of translation preinitiation complex (GO:0001731)4.80141690
4DNA strand elongation involved in DNA replication (GO:0006271)4.78378798
5* protein deneddylation (GO:0000338)4.70395917
6telomere maintenance via semi-conservative replication (GO:0032201)4.55764767
7nucleobase biosynthetic process (GO:0046112)4.53157945
8DNA strand elongation (GO:0022616)4.53143557
9protein maturation by protein folding (GO:0022417)4.53086041
10regulation of mammary gland epithelial cell proliferation (GO:0033599)4.40928634
11DNA replication initiation (GO:0006270)4.26540589
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.24542906
13histone arginine methylation (GO:0034969)4.23590798
14protein retention in ER lumen (GO:0006621)4.23586598
15purine nucleobase biosynthetic process (GO:0009113)4.18990696
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11665273
17peptidyl-arginine omega-N-methylation (GO:0035247)4.00665608
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.99243773
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.91808558
20telomere maintenance via recombination (GO:0000722)3.89349553
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.85982991
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.85712013
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.85038477
24proline metabolic process (GO:0006560)3.84706329
25DNA replication checkpoint (GO:0000076)3.82998463
26negative regulation of ligase activity (GO:0051352)3.81144980
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81144980
28negative regulation of cell size (GO:0045792)3.79686917
29L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.78220842
30regulation of translational fidelity (GO:0006450)3.75912507
31proteasome assembly (GO:0043248)3.74104139
32DNA unwinding involved in DNA replication (GO:0006268)3.73851235
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.73312842
34L-serine metabolic process (GO:0006563)3.70686649
35spliceosomal snRNP assembly (GO:0000387)3.69541215
36ribosome biogenesis (GO:0042254)3.68247589
37folic acid-containing compound biosynthetic process (GO:0009396)3.59650856
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59396152
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59153523
40IMP biosynthetic process (GO:0006188)3.56677777
41mitotic recombination (GO:0006312)3.55411659
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54138091
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54138091
44telomere maintenance via telomere lengthening (GO:0010833)3.53204175
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52585690
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49104372
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49104372
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49104372
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.47983985
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43912816
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.43912816
52DNA replication-dependent nucleosome assembly (GO:0006335)3.42137701
53DNA replication-dependent nucleosome organization (GO:0034723)3.42137701
54regulation of cellular amino acid metabolic process (GO:0006521)3.42051748
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.41082964
56de novo posttranslational protein folding (GO:0051084)3.38331432
57COPI coating of Golgi vesicle (GO:0048205)3.37734701
58Golgi transport vesicle coating (GO:0048200)3.37734701
59transcription-coupled nucleotide-excision repair (GO:0006283)3.37304492
60NADH metabolic process (GO:0006734)3.36493893
61melanin biosynthetic process (GO:0042438)3.36462635
62de novo protein folding (GO:0006458)3.36264741
63proline biosynthetic process (GO:0006561)3.34049696
647-methylguanosine mRNA capping (GO:0006370)3.32966856
65mitotic chromosome condensation (GO:0007076)3.32918876
66positive regulation of ligase activity (GO:0051351)3.32581302
67peptidyl-arginine N-methylation (GO:0035246)3.32153340
68peptidyl-arginine methylation (GO:0018216)3.32153340
69mitotic nuclear envelope reassembly (GO:0007084)3.32095357
70nuclear envelope reassembly (GO:0031468)3.32095357
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31878948
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31878948
73tRNA aminoacylation for protein translation (GO:0006418)3.30389808
74viral mRNA export from host cell nucleus (GO:0046784)3.29640305
75pseudouridine synthesis (GO:0001522)3.29625354
76cell cycle G1/S phase transition (GO:0044843)3.29019317
77G1/S transition of mitotic cell cycle (GO:0000082)3.29019317
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.28874010
79gluconeogenesis (GO:0006094)3.27399077
80regulation of ubiquitin-protein transferase activity (GO:0051438)3.25848271
81amino acid activation (GO:0043038)3.24475019
82tRNA aminoacylation (GO:0043039)3.24475019
837-methylguanosine RNA capping (GO:0009452)3.24276229
84RNA capping (GO:0036260)3.24276229
85monosaccharide biosynthetic process (GO:0046364)3.23741186
86pentose-phosphate shunt (GO:0006098)3.19695904
87maturation of 5.8S rRNA (GO:0000460)3.19028164
88postreplication repair (GO:0006301)3.18572443
89UV protection (GO:0009650)3.14848624
90protein complex localization (GO:0031503)3.12562924
91base-excision repair, AP site formation (GO:0006285)3.11694331
92hexose biosynthetic process (GO:0019319)3.11532175
93regulation of ligase activity (GO:0051340)3.10124612
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06936357
95oxidative phosphorylation (GO:0006119)3.04784670
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.04770473
97somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04770473
98mitotic nuclear envelope disassembly (GO:0007077)3.03278404
99base-excision repair (GO:0006284)3.02945277
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02390243
101folic acid metabolic process (GO:0046655)3.01879863
102glucose catabolic process (GO:0006007)3.01660666
103histone H2A acetylation (GO:0043968)3.00993498
104termination of RNA polymerase III transcription (GO:0006386)3.00690910
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.00690910
106pyrimidine nucleotide catabolic process (GO:0006244)2.99448106
107deoxyribonucleotide biosynthetic process (GO:0009263)2.99126082
108regulation of mitochondrial translation (GO:0070129)2.98015150
109establishment of protein localization to mitochondrial membrane (GO:0090151)2.97769185
1102-deoxyribonucleotide biosynthetic process (GO:0009265)2.97386445
111deoxyribose phosphate biosynthetic process (GO:0046385)2.97386445
112rRNA transcription (GO:0009303)2.97366520
113melanin metabolic process (GO:0006582)2.96374403
114establishment of integrated proviral latency (GO:0075713)2.96157499
115positive regulation of cell cycle arrest (GO:0071158)2.95967146
116mitochondrial fusion (GO:0008053)2.95421026
117GDP-mannose metabolic process (GO:0019673)2.94798135
118apoptotic process involved in morphogenesis (GO:0060561)2.93996607
119pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93858863
120IMP metabolic process (GO:0046040)2.91677599
121NADPH regeneration (GO:0006740)2.90953644
122regulation of translational termination (GO:0006449)2.90767482
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.90042807
124pentose metabolic process (GO:0019321)2.89683497
125nucleobase-containing small molecule interconversion (GO:0015949)2.88654485
126chaperone-mediated protein transport (GO:0072321)2.88515381
127protein insertion into membrane (GO:0051205)2.88501705
128DNA double-strand break processing (GO:0000729)2.87366824
129ribonucleoprotein complex biogenesis (GO:0022613)2.87216903
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86300187
131amino acid salvage (GO:0043102)2.84580575
132L-methionine biosynthetic process (GO:0071265)2.84580575
133heterochromatin organization (GO:0070828)2.84139043
134adenine nucleotide transport (GO:0051503)2.83482559
135pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.80809578
136mitotic sister chromatid segregation (GO:0000070)2.79144896
137nucleosome disassembly (GO:0006337)2.76661342
138protein-DNA complex disassembly (GO:0032986)2.76661342
139glycolytic process (GO:0006096)2.72206801
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71007109
141snRNA metabolic process (GO:0016073)2.69253434
142pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.68331365
143guanosine-containing compound biosynthetic process (GO:1901070)2.67974195
144purine ribonucleotide transport (GO:0015868)2.67003490
145ribosomal small subunit biogenesis (GO:0042274)2.65258515
146adherens junction assembly (GO:0034333)2.65021935
147barbed-end actin filament capping (GO:0051016)2.58771788
148positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.58611548
149purine nucleotide transport (GO:0015865)2.55524650
150pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.55140715
151pinocytosis (GO:0006907)2.54250549
152tricarboxylic acid cycle (GO:0006099)2.54135646
153regulation of early endosome to late endosome transport (GO:2000641)2.53430379
154glucose 6-phosphate metabolic process (GO:0051156)2.53285146
155positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.53010317
156metallo-sulfur cluster assembly (GO:0031163)2.51696285
157iron-sulfur cluster assembly (GO:0016226)2.51696285
158ncRNA 3-end processing (GO:0043628)2.48752140
159basement membrane organization (GO:0071711)2.47216022
160UTP biosynthetic process (GO:0006228)2.47118033
1614-hydroxyproline metabolic process (GO:0019471)2.46051468
162regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.45759684
163cellular protein complex localization (GO:0034629)2.45212894
164mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.43569097
165mitotic G1 DNA damage checkpoint (GO:0031571)2.43563615
166cell-substrate adherens junction assembly (GO:0007045)2.42327771
167focal adhesion assembly (GO:0048041)2.42327771
168CTP metabolic process (GO:0046036)2.41519303
169CTP biosynthetic process (GO:0006241)2.41519303
170oxaloacetate metabolic process (GO:0006107)2.41109471
171tricarboxylic acid metabolic process (GO:0072350)2.41075052
172snRNA processing (GO:0016180)2.41005237
173mitochondrial DNA metabolic process (GO:0032042)2.40395706
174regulation of cholesterol biosynthetic process (GO:0045540)2.39404241
175maternal placenta development (GO:0001893)2.39345647
176negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.39061526
177establishment of viral latency (GO:0019043)2.38677651
178activation of Rac GTPase activity (GO:0032863)2.38364618
179pyrimidine nucleoside salvage (GO:0043097)2.38225614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19986930
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34307177
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.30195979
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86654920
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75060756
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.47126879
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.38878020
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.35591549
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33074948
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30984755
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20645995
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06528417
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93429954
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87090405
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.82089441
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.78899737
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59240539
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48623145
19XRN2_22483619_ChIP-Seq_HELA_Human2.45392876
20DCP1A_22483619_ChIP-Seq_HELA_Human2.41862309
21GABP_19822575_ChIP-Seq_HepG2_Human2.41150627
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39389908
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34900476
24VDR_21846776_ChIP-Seq_THP-1_Human2.27414330
25LXR_22292898_ChIP-Seq_THP-1_Human2.27166267
26VDR_23849224_ChIP-Seq_CD4+_Human2.23679601
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23169035
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21220836
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20898534
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.16566394
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16080143
32FOXP3_21729870_ChIP-Seq_TREG_Human2.01046813
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.00930973
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00749513
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97525883
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95175847
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95020737
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.94767026
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94565138
40ZNF263_19887448_ChIP-Seq_K562_Human1.94075200
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.91253392
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.89941588
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89441859
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.86660648
45TTF2_22483619_ChIP-Seq_HELA_Human1.85097436
46RACK7_27058665_Chip-Seq_MCF-7_Human1.83211054
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77975374
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76233265
49AR_21909140_ChIP-Seq_LNCAP_Human1.75206375
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69263015
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68565111
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66481519
53P68_20966046_ChIP-Seq_HELA_Human1.63589740
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60353979
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58189168
56KDM5A_27292631_Chip-Seq_BREAST_Human1.55607669
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54626398
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54123697
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51601690
60CIITA_25753668_ChIP-Seq_RAJI_Human1.48755822
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44781872
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.43988398
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.42732881
64* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40254440
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38478590
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38239712
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35311519
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34590071
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32880952
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32711375
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31844163
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31392421
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.31053111
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30146735
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29933122
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29620007
77ELK1_19687146_ChIP-ChIP_HELA_Human1.29584121
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27852033
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27061230
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.25815396
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25683840
82* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24260471
83KDM2B_26808549_Chip-Seq_DND41_Human1.23431610
84TFEB_21752829_ChIP-Seq_HELA_Human1.21572190
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21046773
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20914007
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20580493
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19970333
89SMC4_20622854_ChIP-Seq_HELA_Human1.19951144
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.19931428
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18921978
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18758057
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18514361
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17316683
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17185561
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17087560
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15227288
98* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14654150
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14633684
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13862129
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13404795
102SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13326972
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12202494
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11984496
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11306786
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11130573
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10905063
108MYC_22102868_ChIP-Seq_BL_Human1.10902881
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10454598
110TCF7_22412390_ChIP-Seq_EML_Mouse1.10406818
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.10046586
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10023809
113ATF3_27146783_Chip-Seq_COLON_Human1.09955800
114BCOR_27268052_Chip-Seq_Bcells_Human1.08622647
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06408140
116PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06303551
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.05669696
118MAF_26560356_Chip-Seq_TH2_Human1.05569686
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05267273
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04981035
121BCL6_27268052_Chip-Seq_Bcells_Human1.04396249
122RARB_24833708_ChIP-Seq_LIVER_Mouse1.04014599
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03973048
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02847095
125PHF8_20622854_ChIP-Seq_HELA_Human1.02174989
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01354007
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01040046
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98213207
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.97472527
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.96756973
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96552552
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95014942
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94343260
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.92554546
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91478962
136FOXP1_21924763_ChIP-Seq_HESCs_Human0.91053995
137MYC_18940864_ChIP-ChIP_HL60_Human0.89816169
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88891823
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87692006
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87267662
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.86037179
142SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85636380
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84311942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.21438231
2MP0004957_abnormal_blastocyst_morpholog4.15903892
3MP0010094_abnormal_chromosome_stability3.89042161
4MP0003111_abnormal_nucleus_morphology3.50547834
5MP0008058_abnormal_DNA_repair3.46559846
6MP0003705_abnormal_hypodermis_morpholog3.36344572
7MP0005058_abnormal_lysosome_morphology3.33931012
8MP0003077_abnormal_cell_cycle3.18380495
9MP0005451_abnormal_body_composition3.13293171
10MP0003123_paternal_imprinting3.09870187
11MP0008877_abnormal_DNA_methylation2.97530087
12MP0008260_abnormal_autophagy2.94067976
13MP0008007_abnormal_cellular_replicative2.86481995
14MP0008932_abnormal_embryonic_tissue2.74302441
15MP0002653_abnormal_ependyma_morphology2.74236757
16MP0008057_abnormal_DNA_replication2.71337919
17MP0005171_absent_coat_pigmentation2.64408340
18MP0002877_abnormal_melanocyte_morpholog2.56056850
19MP0010030_abnormal_orbit_morphology2.46125922
20MP0003786_premature_aging2.44569809
21MP0004233_abnormal_muscle_weight2.34292195
22MP0004858_abnormal_nervous_system2.25109095
23MP0004185_abnormal_adipocyte_glucose2.21814623
24MP0003122_maternal_imprinting2.17308691
25MP0001730_embryonic_growth_arrest2.10689920
26MP0001849_ear_inflammation2.09587049
27MP0002249_abnormal_larynx_morphology1.95384892
28MP0001529_abnormal_vocalization1.93685320
29MP0003121_genomic_imprinting1.85999369
30MP0005076_abnormal_cell_differentiation1.84621014
31MP0000350_abnormal_cell_proliferation1.82112808
32MP0001661_extended_life_span1.80889124
33MP0005501_abnormal_skin_physiology1.76238545
34MP0000747_muscle_weakness1.74007872
35MP0004133_heterotaxia1.73664582
36MP0005330_cardiomyopathy1.71738220
37MP0001697_abnormal_embryo_size1.66828911
38MP0005257_abnormal_intraocular_pressure1.63030668
39MP0002160_abnormal_reproductive_system1.62995193
40MP0000358_abnormal_cell_content/1.61800100
41MP0000003_abnormal_adipose_tissue1.60972242
42MP0006036_abnormal_mitochondrial_physio1.60200179
43MP0009840_abnormal_foam_cell1.57336447
44MP0003806_abnormal_nucleotide_metabolis1.56597126
45MP0002080_prenatal_lethality1.56401234
46MP0003119_abnormal_digestive_system1.54275677
47MP0009672_abnormal_birth_weight1.49195438
48MP0003136_yellow_coat_color1.46822704
49MP0001346_abnormal_lacrimal_gland1.42894873
50MP0005623_abnormal_meninges_morphology1.42235020
51MP0006035_abnormal_mitochondrial_morpho1.41587053
52MP0001672_abnormal_embryogenesis/_devel1.37058679
53MP0005380_embryogenesis_phenotype1.37058679
54MP0000750_abnormal_muscle_regeneration1.36123723
55MP0001929_abnormal_gametogenesis1.35987659
56MP0000759_abnormal_skeletal_muscle1.35228350
57MP0003890_abnormal_embryonic-extraembry1.34746199
58MP0002085_abnormal_embryonic_tissue1.32858133
59MP0002210_abnormal_sex_determination1.32355715
60MP0002084_abnormal_developmental_patter1.30450067
61MP0002796_impaired_skin_barrier1.29647596
62MP0003566_abnormal_cell_adhesion1.28817964
63MP0001145_abnormal_male_reproductive1.28035178
64MP0003718_maternal_effect1.26013163
65MP0003984_embryonic_growth_retardation1.25624123
66MP0002088_abnormal_embryonic_growth/wei1.22404640
67MP0005670_abnormal_white_adipose1.21933807
68MP0005666_abnormal_adipose_tissue1.21208866
69MP0000013_abnormal_adipose_tissue1.21066717
70MP0000313_abnormal_cell_death1.19336203
71MP0000749_muscle_degeneration1.18915261
72MP0004197_abnormal_fetal_growth/weight/1.18901829
73MP0000372_irregular_coat_pigmentation1.17748956
74MP0003453_abnormal_keratinocyte_physiol1.17719354
75MP0000733_abnormal_muscle_development1.17022924
76MP0010234_abnormal_vibrissa_follicle1.15718661
77MP0002269_muscular_atrophy1.14048241
78MP0003283_abnormal_digestive_organ1.14039550
79MP0004087_abnormal_muscle_fiber1.12828424
80MP0000566_synostosis1.12686500
81MP0003880_abnormal_central_pattern1.11327522
82MP0005410_abnormal_fertilization1.11324839
83MP0008438_abnormal_cutaneous_collagen1.10650828
84MP0005375_adipose_tissue_phenotype1.10432455
85MP0003329_amyloid_beta_deposits1.08800887
86MP0000490_abnormal_crypts_of1.08551590
87MP0005409_darkened_coat_color1.07032090
88MP0003698_abnormal_male_reproductive1.06588273
89MP0003115_abnormal_respiratory_system1.06118632
90MP0000653_abnormal_sex_gland1.06107610
91MP0005408_hypopigmentation1.05532320
92MP0002751_abnormal_autonomic_nervous1.04683982
93MP0003942_abnormal_urinary_system1.04501863
94MP0005389_reproductive_system_phenotype1.02331328
95MP0006054_spinal_hemorrhage1.01484535
96MP0001293_anophthalmia1.00406907
97MP0005083_abnormal_biliary_tract1.00280042
98MP0002086_abnormal_extraembryonic_tissu0.99454425
99MP0005220_abnormal_exocrine_pancreas0.99014456
100MP0000015_abnormal_ear_pigmentation0.98926198
101MP0003191_abnormal_cellular_cholesterol0.98297955
102MP0005621_abnormal_cell_physiology0.96611242
103MP0003172_abnormal_lysosome_physiology0.95958326
104MP0004381_abnormal_hair_follicle0.95170225
105MP0002822_catalepsy0.94929424
106MP0008789_abnormal_olfactory_epithelium0.94000677
107MP0004272_abnormal_basement_membrane0.93491598
108MP0002060_abnormal_skin_morphology0.92777779
109MP0002736_abnormal_nociception_after0.92272704
110MP0002396_abnormal_hematopoietic_system0.92218182
111MP0004859_abnormal_synaptic_plasticity0.91797723
112MP0009278_abnormal_bone_marrow0.91362702
113MP0009333_abnormal_splenocyte_physiolog0.90242219
114MP0002019_abnormal_tumor_incidence0.90128016
115MP0003787_abnormal_imprinting0.90076854
116MP0000537_abnormal_urethra_morphology0.89544125
117MP0003186_abnormal_redox_activity0.87898280
118MP0000858_altered_metastatic_potential0.87320880
119MP0005499_abnormal_olfactory_system0.87033912
120MP0005394_taste/olfaction_phenotype0.87033912
121MP0010630_abnormal_cardiac_muscle0.85772924
122MP0003385_abnormal_body_wall0.83836720
123MP0002161_abnormal_fertility/fecundity0.83797175
124MP0000681_abnormal_thyroid_gland0.83534473
125MP0005266_abnormal_metabolism0.83477750
126MP0004811_abnormal_neuron_physiology0.83243307
127MP0001348_abnormal_lacrimal_gland0.81450627
128MP0006138_congestive_heart_failure0.79955273
129MP0000678_abnormal_parathyroid_gland0.79872991
130MP0000049_abnormal_middle_ear0.79290774
131MP0002075_abnormal_coat/hair_pigmentati0.78935234
132MP0005384_cellular_phenotype0.78005138
133MP0002111_abnormal_tail_morphology0.77483580
134MP0000534_abnormal_ureter_morphology0.75931589
135MP0003861_abnormal_nervous_system0.74712126
136MP0005646_abnormal_pituitary_gland0.70668658
137MP0002970_abnormal_white_adipose0.70403750
138MP0002938_white_spotting0.70300730
139MP0001186_pigmentation_phenotype0.69818454
140MP0006292_abnormal_olfactory_placode0.69677955
141MP0009384_cardiac_valve_regurgitation0.68337889
142MP0001119_abnormal_female_reproductive0.67691107
143MP0010352_gastrointestinal_tract_polyps0.67474510
144MP0002063_abnormal_learning/memory/cond0.66451365
145MP0001545_abnormal_hematopoietic_system0.66300759
146MP0005397_hematopoietic_system_phenotyp0.66300759
147MP0004147_increased_porphyrin_level0.66184016
148MP0001984_abnormal_olfaction0.63975380
149MP0003315_abnormal_perineum_morphology0.63868147
150MP0002102_abnormal_ear_morphology0.63867682
151MP0006276_abnormal_autonomic_nervous0.63676952
152MP0001905_abnormal_dopamine_level0.63299018
153MP0004142_abnormal_muscle_tone0.62354506
154MP0002184_abnormal_innervation0.60961853
155MP0003221_abnormal_cardiomyocyte_apopto0.60614103
156MP0002089_abnormal_postnatal_growth/wei0.60611958
157MP0002114_abnormal_axial_skeleton0.59527594
158MP0002282_abnormal_trachea_morphology0.58680091
159MP0000751_myopathy0.58068928

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.17592660
2Birth length less than 3rd percentile (HP:0003561)4.15863106
3Increased serum pyruvate (HP:0003542)3.95041193
4Abnormality of glycolysis (HP:0004366)3.95041193
5Abnormal mitochondria in muscle tissue (HP:0008316)3.79925202
6Acute necrotizing encephalopathy (HP:0006965)3.78252013
7Abnormality of the anterior horn cell (HP:0006802)3.71314146
8Degeneration of anterior horn cells (HP:0002398)3.71314146
9Ulnar bowing (HP:0003031)3.44068753
10Hepatocellular necrosis (HP:0001404)3.41982523
11Testicular atrophy (HP:0000029)3.38736550
12Myopathic facies (HP:0002058)3.30350813
13Hyperacusis (HP:0010780)3.29329835
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.24280255
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.24280255
16Increased CSF lactate (HP:0002490)3.23369266
17Mitochondrial inheritance (HP:0001427)3.22089464
18Vertebral compression fractures (HP:0002953)3.21607142
19Oral leukoplakia (HP:0002745)3.12194061
20Acute encephalopathy (HP:0006846)3.10849649
21Achilles tendon contracture (HP:0001771)2.97940071
22Unsteady gait (HP:0002317)2.97774413
23Increased serum lactate (HP:0002151)2.96364632
24Aplastic anemia (HP:0001915)2.95612531
25Hepatic necrosis (HP:0002605)2.91558655
26Hypoplasia of the pons (HP:0012110)2.85212584
27Selective tooth agenesis (HP:0001592)2.84946733
28Abnormality of the labia minora (HP:0012880)2.84852298
29Microvesicular hepatic steatosis (HP:0001414)2.84620793
30Progressive muscle weakness (HP:0003323)2.84588562
31Patellar aplasia (HP:0006443)2.80226272
32Stridor (HP:0010307)2.76653969
33Progressive macrocephaly (HP:0004481)2.75857008
34Emotional lability (HP:0000712)2.74276340
35Poor suck (HP:0002033)2.68630556
36Postnatal microcephaly (HP:0005484)2.67653939
37Abnormality of the Achilles tendon (HP:0005109)2.64791713
38Broad distal phalanx of finger (HP:0009836)2.64685084
39Upper limb amyotrophy (HP:0009129)2.64006913
40Distal upper limb amyotrophy (HP:0007149)2.64006913
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.61722624
42Abnormality of cells of the erythroid lineage (HP:0012130)2.61233414
4311 pairs of ribs (HP:0000878)2.60102603
44Abnormal number of erythroid precursors (HP:0012131)2.59864772
45Distal lower limb amyotrophy (HP:0008944)2.59671817
46Premature rupture of membranes (HP:0001788)2.58198997
47Breast hypoplasia (HP:0003187)2.56799512
48Aplasia/Hypoplasia of the patella (HP:0006498)2.56433229
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.56140135
50Distal lower limb muscle weakness (HP:0009053)2.52400026
51Abnormality of the umbilical cord (HP:0010881)2.51837864
52Abnormality of the pons (HP:0007361)2.51664248
53Tongue fasciculations (HP:0001308)2.48773583
54Biconcave vertebral bodies (HP:0004586)2.46598480
55Cholelithiasis (HP:0001081)2.45360344
56CNS hypomyelination (HP:0003429)2.45160655
57Rough bone trabeculation (HP:0100670)2.43760946
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42415520
59Abnormality of alanine metabolism (HP:0010916)2.42415520
60Hyperalaninemia (HP:0003348)2.42415520
61Delusions (HP:0000746)2.41953198
62CNS demyelination (HP:0007305)2.41917372
63Microretrognathia (HP:0000308)2.37586520
64Broad face (HP:0000283)2.37362501
65Lactic acidosis (HP:0003128)2.35364932
66Premature graying of hair (HP:0002216)2.33553537
67Neuroendocrine neoplasm (HP:0100634)2.33474713
68Abnormality of the lower motor neuron (HP:0002366)2.32520990
69Increased connective tissue (HP:0009025)2.30923198
70Exercise intolerance (HP:0003546)2.28089430
71Abnormality of the distal phalanges of the toes (HP:0010182)2.27143411
72Ependymoma (HP:0002888)2.26513227
73Trismus (HP:0000211)2.25900316
74Neoplasm of the peripheral nervous system (HP:0100007)2.23199043
75Long palpebral fissure (HP:0000637)2.19161189
76Insomnia (HP:0100785)2.18686041
77Hand muscle atrophy (HP:0009130)2.18383986
78Secondary amenorrhea (HP:0000869)2.14558611
79Pheochromocytoma (HP:0002666)2.14421505
80Muscle fibrillation (HP:0010546)2.14017332
81Respiratory failure (HP:0002878)2.10853831
82Facial cleft (HP:0002006)2.10145373
83Proximal placement of thumb (HP:0009623)2.08664363
84Missing ribs (HP:0000921)2.08206398
85Premature skin wrinkling (HP:0100678)2.07586154
86Protrusio acetabuli (HP:0003179)2.07565392
87Slender long bone (HP:0003100)2.07280775
88Shoulder girdle muscle weakness (HP:0003547)2.07222102
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07053667
90Prominent metopic ridge (HP:0005487)2.07038496
91Cervical subluxation (HP:0003308)2.06094328
92Turricephaly (HP:0000262)2.05533158
93Type I transferrin isoform profile (HP:0003642)2.03813585
94Abnormality of the gallbladder (HP:0005264)2.03625905
95Exercise-induced myalgia (HP:0003738)2.03505816
96Abnormal gallbladder morphology (HP:0012437)2.01657651
97Progressive external ophthalmoplegia (HP:0000590)1.99467228
98Deviation of the thumb (HP:0009603)1.99256621
99Thin bony cortex (HP:0002753)1.98617502
100Abnormality of the fetal cardiovascular system (HP:0010948)1.95387753
101Abnormal umbilical cord blood vessels (HP:0011403)1.95387753
102Single umbilical artery (HP:0001195)1.95387753
103Orthostatic hypotension (HP:0001278)1.95195937
104Lower limb amyotrophy (HP:0007210)1.94558994
105Disproportionate tall stature (HP:0001519)1.92958449
106Generalized amyotrophy (HP:0003700)1.91592632
107Megaloblastic anemia (HP:0001889)1.91132239
108Congenital primary aphakia (HP:0007707)1.90910202
109Multiple enchondromatosis (HP:0005701)1.90641796
110Hemorrhage of the eye (HP:0011885)1.90220346
111Agnosia (HP:0010524)1.90040794
112Elbow flexion contracture (HP:0002987)1.89415297
113Neoplasm of the adrenal gland (HP:0100631)1.89134384
114Vaginal fistula (HP:0004320)1.88619072
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87901288
116Short nail (HP:0001799)1.87837960
117Adenoma sebaceum (HP:0009720)1.87600997
118Angiofibromas (HP:0010615)1.87600997
119Pointed chin (HP:0000307)1.87453160
120Premature ovarian failure (HP:0008209)1.86517695
121Ragged-red muscle fibers (HP:0003200)1.86040937
122Carpal bone hypoplasia (HP:0001498)1.85496491
123Type 2 muscle fiber atrophy (HP:0003554)1.84131222
124Thin ribs (HP:0000883)1.82610458
125Gait imbalance (HP:0002141)1.82364275
126Difficulty climbing stairs (HP:0003551)1.82128335
127Annular pancreas (HP:0001734)1.82073990
128Leukodystrophy (HP:0002415)1.81489897
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81424708
130Abnormal protein N-linked glycosylation (HP:0012347)1.81424708
131Abnormal protein glycosylation (HP:0012346)1.81424708
132Abnormal glycosylation (HP:0012345)1.81424708
133Colon cancer (HP:0003003)1.81409329
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81134751
135Truncus arteriosus (HP:0001660)1.80685783
136Reticulocytosis (HP:0001923)1.80019505
137Back pain (HP:0003418)1.79928917
138Rhabdomyolysis (HP:0003201)1.79190527
139Abnormality of the motor neurons (HP:0002450)1.78434702
140Abnormal neuron morphology (HP:0012757)1.78434702
141Nephrogenic diabetes insipidus (HP:0009806)1.78366804
142Neoplasm of the pancreas (HP:0002894)1.77193465
143Abnormalities of placenta or umbilical cord (HP:0001194)1.76855786
144Prolonged neonatal jaundice (HP:0006579)1.75247369
145Cellular immunodeficiency (HP:0005374)1.75034363
146Muscle fiber atrophy (HP:0100295)1.74959087
147Abnormality of the metopic suture (HP:0005556)1.74833697
148Hypokinesia (HP:0002375)1.73101072
149J-shaped sella turcica (HP:0002680)1.72437789
150Cerebral edema (HP:0002181)1.71270310
151Bulbar palsy (HP:0001283)1.70255874
152Dysautonomia (HP:0002459)1.70115571
153Poor head control (HP:0002421)1.69977657
154Abnormality of the thoracic spine (HP:0100711)1.69901499
155Medial flaring of the eyebrow (HP:0010747)1.69789519
156Spinal rigidity (HP:0003306)1.68659727
157Reticulocytopenia (HP:0001896)1.67621282
158Flattened epiphyses (HP:0003071)1.67459811
159Lissencephaly (HP:0001339)1.67457767
160Abnormality of dentin (HP:0010299)1.66678689
161Abnormality of the calcaneus (HP:0008364)1.66296780
162Cholecystitis (HP:0001082)1.66078744
163Abnormal gallbladder physiology (HP:0012438)1.66078744
164Absent epiphyses (HP:0010577)1.65759773
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65759773
166Diaphragmatic weakness (HP:0009113)1.65694523
167Deep venous thrombosis (HP:0002625)1.65537969
168Opisthotonus (HP:0002179)1.65470377
169Broad foot (HP:0001769)1.65089712
170Bowing of the arm (HP:0006488)1.63662192
171Bowed forearm bones (HP:0003956)1.63662192
172Mildly elevated creatine phosphokinase (HP:0008180)1.63201082
173Poikiloderma (HP:0001029)1.62627364
174Cerebral aneurysm (HP:0004944)1.62278025
175Abnormality of skeletal muscle fiber size (HP:0012084)1.62114156
176Abnormal trabecular bone morphology (HP:0100671)1.61120047
177Self-mutilation (HP:0000742)1.59430609
178Congenital hip dislocation (HP:0001374)1.58797262
179Nonimmune hydrops fetalis (HP:0001790)1.58760565
180Short clavicles (HP:0000894)1.57661906
181Abnormality of the tricuspid valve (HP:0001702)1.55927179
182Increased variability in muscle fiber diameter (HP:0003557)1.55870472
183Atelectasis (HP:0100750)1.55235480
184Reduced antithrombin III activity (HP:0001976)1.52821879
185High anterior hairline (HP:0009890)1.52588750
186Mitral regurgitation (HP:0001653)1.52061404
187Squamous cell carcinoma (HP:0002860)1.51499116
188Impaired pain sensation (HP:0007328)1.50641496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.10988614
2SMG13.83030281
3EIF2AK13.75043878
4CDC73.16219191
5TSSK63.03562647
6WEE12.81504011
7NEK12.69105099
8TESK22.55366370
9TESK12.37062915
10EIF2AK32.33159304
11IRAK32.27958716
12DAPK12.21501356
13STK162.20947029
14PASK2.08700173
15SIK12.06305641
16PDK32.04646362
17PDK42.04646362
18MAP3K122.04448736
19ERN12.03991543
20VRK21.95700161
21CCNB11.86144500
22SCYL21.80094733
23NME11.77379606
24CDK81.76284706
25BRAF1.67766064
26TTN1.58605982
27NME21.53350851
28VRK11.52270186
29BRSK11.49121863
30MST1R1.48758789
31PLK11.44239447
32PRPF4B1.41783922
33TLK11.41598239
34MAP3K101.38691090
35ARAF1.37921134
36NEK21.37041041
37ACVR1B1.36546045
38LIMK11.35862820
39AURKA1.34219672
40PKN21.33948947
41MAP3K111.33916064
42MAP2K31.33833103
43SRPK11.31363711
44PIM21.29814429
45PLK31.29732334
46PRKD31.26818675
47CDK121.24546033
48PAK41.24307396
49DYRK31.21202211
50TTK1.11041660
51BCKDK1.09208572
52BRSK21.08494311
53TGFBR11.06916199
54* ATR1.03147123
55CHEK21.01238321
56CDK70.99492862
57RIPK10.97817460
58AURKB0.93064050
59DYRK20.92000215
60FGFR40.91896164
61MINK10.90796728
62PDK20.90763896
63ILK0.89739588
64LMTK20.86527780
65STK38L0.86455304
66PLK20.85157773
67MAP2K70.84940871
68MTOR0.83617037
69CDK180.83281644
70MKNK10.83239137
71PBK0.82669640
72PRKD20.82163349
73RPS6KB20.80488545
74MYLK0.79894908
75PTK20.79841262
76RAF10.78363686
77MAPK110.78291663
78AKT20.76444280
79CDK150.76082022
80AKT30.75887903
81LRRK20.74950738
82PTK60.74371267
83CHEK10.73294221
84PAK10.72715541
85SIK30.72662346
86ERBB30.72227360
87IRAK20.71850677
88CDK140.69029918
89CDK190.68498120
90LATS20.67817789
91CDK11A0.67391690
92UHMK10.67184712
93MAP3K30.66189017
94KSR10.64695640
95PRKCI0.63451830
96NTRK10.62767110
97KDR0.61902832
98PDGFRA0.60379983
99MAP3K40.59017448
100RPS6KA20.58203318
101MAPKAPK30.55786287
102CSNK2A10.55756629
103PLK40.55604205
104BMX0.55542766
105MARK20.55282241
106ABL20.55261474
107MET0.54870829
108PDPK10.54589033
109CASK0.53305566
110CSNK2A20.52147505
111CDK20.51521107
112MAP3K60.51464058
113TAOK20.50804201
114EPHA20.50278791
115PAK60.49488363
116GRK60.49294484
117BCR0.48728042
118TBK10.48560286
119TAOK10.47129062
120DDR20.47060659
121FGFR10.46455328
122MAP2K20.45763080
123MAP3K80.45382084
124TRIB30.44868239
125RPS6KB10.43452806
126EEF2K0.43118468
127PRKCG0.41908866
128CDK40.40857068
129CSNK1A1L0.40157896
130DYRK1B0.39309000
131CAMK2G0.37348068
132PAK20.36583857
133CDK10.35644121
134KSR20.34829372
135DAPK30.31642178
136ATM0.31517623
137ICK0.29720005
138PINK10.29494042
139CSNK1G30.29170926
140NTRK30.28679820
141RPS6KA40.28472687
142RPS6KL10.27397100
143RPS6KC10.27397100

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72407088
2Proteasome_Homo sapiens_hsa030504.35754268
3Mismatch repair_Homo sapiens_hsa034303.91174291
4Base excision repair_Homo sapiens_hsa034103.36139404
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14568823
6RNA polymerase_Homo sapiens_hsa030202.98639864
7RNA transport_Homo sapiens_hsa030132.83686037
8Spliceosome_Homo sapiens_hsa030402.83681327
9Nucleotide excision repair_Homo sapiens_hsa034202.82542219
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82314789
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81107174
12Pyrimidine metabolism_Homo sapiens_hsa002402.35438180
13Ribosome_Homo sapiens_hsa030102.25014164
14Homologous recombination_Homo sapiens_hsa034402.16507201
15Cell cycle_Homo sapiens_hsa041102.05449199
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95606000
17Other glycan degradation_Homo sapiens_hsa005111.94080610
18Oxidative phosphorylation_Homo sapiens_hsa001901.89607178
19One carbon pool by folate_Homo sapiens_hsa006701.85735510
20Parkinsons disease_Homo sapiens_hsa050121.83499659
21Protein export_Homo sapiens_hsa030601.78330575
22Biosynthesis of amino acids_Homo sapiens_hsa012301.63023712
23Basal transcription factors_Homo sapiens_hsa030221.52093154
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.51826828
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.51596700
26Huntingtons disease_Homo sapiens_hsa050161.50169194
27mRNA surveillance pathway_Homo sapiens_hsa030151.49226661
28RNA degradation_Homo sapiens_hsa030181.47218397
29Fatty acid elongation_Homo sapiens_hsa000621.36863945
30Purine metabolism_Homo sapiens_hsa002301.36126673
31Carbon metabolism_Homo sapiens_hsa012001.27705850
32Vibrio cholerae infection_Homo sapiens_hsa051101.24257079
33Fanconi anemia pathway_Homo sapiens_hsa034601.23930674
34Synaptic vesicle cycle_Homo sapiens_hsa047211.21847427
35Pyruvate metabolism_Homo sapiens_hsa006201.21613300
36N-Glycan biosynthesis_Homo sapiens_hsa005101.21399945
37Phenylalanine metabolism_Homo sapiens_hsa003601.18886000
38Oocyte meiosis_Homo sapiens_hsa041141.17382176
39Non-homologous end-joining_Homo sapiens_hsa034501.15107006
40Fructose and mannose metabolism_Homo sapiens_hsa000511.13559443
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12806863
42Collecting duct acid secretion_Homo sapiens_hsa049661.10634427
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09924661
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04797778
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02369765
46Arginine biosynthesis_Homo sapiens_hsa002200.97115098
47Folate biosynthesis_Homo sapiens_hsa007900.96629219
48Alzheimers disease_Homo sapiens_hsa050100.93021869
49p53 signaling pathway_Homo sapiens_hsa041150.90636722
50Notch signaling pathway_Homo sapiens_hsa043300.85565306
51Chronic myeloid leukemia_Homo sapiens_hsa052200.85511078
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.85204278
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81968536
54Pentose phosphate pathway_Homo sapiens_hsa000300.81900344
55Epstein-Barr virus infection_Homo sapiens_hsa051690.81319448
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81011143
57Prion diseases_Homo sapiens_hsa050200.80936096
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79920095
59Fatty acid metabolism_Homo sapiens_hsa012120.78165820
60Non-small cell lung cancer_Homo sapiens_hsa052230.77726678
61Selenocompound metabolism_Homo sapiens_hsa004500.76588685
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76446609
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74258146
64Sulfur relay system_Homo sapiens_hsa041220.73246203
65Tyrosine metabolism_Homo sapiens_hsa003500.73077082
66AMPK signaling pathway_Homo sapiens_hsa041520.72691967
67Sulfur metabolism_Homo sapiens_hsa009200.69718399
68Acute myeloid leukemia_Homo sapiens_hsa052210.68490514
69Insulin signaling pathway_Homo sapiens_hsa049100.67035662
70Lysine degradation_Homo sapiens_hsa003100.64957962
71Galactose metabolism_Homo sapiens_hsa000520.61319400
72VEGF signaling pathway_Homo sapiens_hsa043700.60584160
73Vitamin B6 metabolism_Homo sapiens_hsa007500.60542728
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57988519
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57806390
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57056408
77Alcoholism_Homo sapiens_hsa050340.56931864
78Pancreatic cancer_Homo sapiens_hsa052120.56182481
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55929360
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.53614840
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51543940
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51487189
83Metabolic pathways_Homo sapiens_hsa011000.49594693
84Lysosome_Homo sapiens_hsa041420.48973318
85Systemic lupus erythematosus_Homo sapiens_hsa053220.48420992
86Thyroid cancer_Homo sapiens_hsa052160.48106948
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48060744
88Small cell lung cancer_Homo sapiens_hsa052220.45801121
89Endocytosis_Homo sapiens_hsa041440.45705306
90Viral carcinogenesis_Homo sapiens_hsa052030.44465790
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44180188
92Endometrial cancer_Homo sapiens_hsa052130.43168102
93Bladder cancer_Homo sapiens_hsa052190.42721445
94Glioma_Homo sapiens_hsa052140.42225701
95Apoptosis_Homo sapiens_hsa042100.39133000
96Legionellosis_Homo sapiens_hsa051340.39013166
97Steroid biosynthesis_Homo sapiens_hsa001000.37680284
98Glutathione metabolism_Homo sapiens_hsa004800.37655717
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35695427
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35308910
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34168080
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33798082
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33651978
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32506067
105Regulation of autophagy_Homo sapiens_hsa041400.31028362
106Arginine and proline metabolism_Homo sapiens_hsa003300.30796523
107Hippo signaling pathway_Homo sapiens_hsa043900.28979718
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.28927051
109Cardiac muscle contraction_Homo sapiens_hsa042600.28753541
110Shigellosis_Homo sapiens_hsa051310.25059066
111Phagosome_Homo sapiens_hsa041450.23678218
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22540878
113HTLV-I infection_Homo sapiens_hsa051660.22306746
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21584401
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21121822
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20969480
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20920648
118Type I diabetes mellitus_Homo sapiens_hsa049400.20735142
119Hedgehog signaling pathway_Homo sapiens_hsa043400.20380727
120Propanoate metabolism_Homo sapiens_hsa006400.18623734
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.17149990
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16342708
123Colorectal cancer_Homo sapiens_hsa052100.13063266
124Amphetamine addiction_Homo sapiens_hsa050310.11966834
125Dopaminergic synapse_Homo sapiens_hsa047280.11777535
126Antigen processing and presentation_Homo sapiens_hsa046120.10470343
127mTOR signaling pathway_Homo sapiens_hsa041500.09472307
128Gap junction_Homo sapiens_hsa045400.09242514
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08767671
130Glucagon signaling pathway_Homo sapiens_hsa049220.06342820
131HIF-1 signaling pathway_Homo sapiens_hsa040660.04936394
132Nicotine addiction_Homo sapiens_hsa050330.02979270
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.02925327

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »