GPS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.46364014
2DNA deamination (GO:0045006)5.21930151
3telomere maintenance via semi-conservative replication (GO:0032201)4.53312902
4viral transcription (GO:0019083)4.33297552
5GDP-mannose metabolic process (GO:0019673)4.30013595
6DNA strand elongation involved in DNA replication (GO:0006271)4.28096688
7rRNA modification (GO:0000154)4.26842426
8translational termination (GO:0006415)4.14118722
9DNA strand elongation (GO:0022616)4.09916385
10telomere maintenance via recombination (GO:0000722)4.06023956
11ribosomal small subunit biogenesis (GO:0042274)4.05417817
12cytidine metabolic process (GO:0046087)4.03021597
13cytidine catabolic process (GO:0006216)4.03021597
14cytidine deamination (GO:0009972)4.03021597
15positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95500747
16purine deoxyribonucleotide catabolic process (GO:0009155)3.81914595
17negative regulation of cell killing (GO:0031342)3.77254610
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77254610
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71923756
20translational elongation (GO:0006414)3.71604379
21mitotic recombination (GO:0006312)3.65979701
22cotranslational protein targeting to membrane (GO:0006613)3.60242018
23protein targeting to ER (GO:0045047)3.59587556
24DNA replication checkpoint (GO:0000076)3.56401119
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52489938
26rRNA methylation (GO:0031167)3.51024826
27DNA replication initiation (GO:0006270)3.50074588
28maturation of SSU-rRNA (GO:0030490)3.45550333
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45435837
30autophagic vacuole fusion (GO:0000046)3.44892562
31negative regulation of B cell apoptotic process (GO:0002903)3.42945289
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.40325328
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39418938
34protein localization to endoplasmic reticulum (GO:0070972)3.38599070
35telomere maintenance via telomere lengthening (GO:0010833)3.35154639
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34451406
37positive thymic T cell selection (GO:0045059)3.34025074
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30553271
39translational initiation (GO:0006413)3.28264289
40deoxyribonucleotide catabolic process (GO:0009264)3.26329913
41viral life cycle (GO:0019058)3.22877006
42pyrimidine ribonucleoside catabolic process (GO:0046133)3.22846216
43purine deoxyribonucleotide metabolic process (GO:0009151)3.21861626
44cellular protein complex disassembly (GO:0043624)3.18854304
45nucleotide salvage (GO:0043173)3.14000620
46organelle membrane fusion (GO:0090174)3.12972602
47response to interferon-beta (GO:0035456)3.12368801
48purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.12174272
49positive regulation of defense response to virus by host (GO:0002230)3.10995543
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10764274
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.08832637
52positive regulation of gamma-delta T cell activation (GO:0046645)3.06607845
53negative regulation of DNA-templated transcription, elongation (GO:0032785)3.03700806
54regulation of autophagic vacuole assembly (GO:2000785)3.02005184
55negative regulation of T-helper cell differentiation (GO:0045623)3.00496834
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00496834
57protoporphyrinogen IX metabolic process (GO:0046501)2.97866409
58pyrimidine nucleoside salvage (GO:0043097)2.97665643
59pyrimidine-containing compound salvage (GO:0008655)2.97665643
60cellular response to interferon-beta (GO:0035458)2.97260828
61positive regulation of B cell differentiation (GO:0045579)2.96793729
62protein complex disassembly (GO:0043241)2.96226036
63base-excision repair, AP site formation (GO:0006285)2.94558177
64deoxyribose phosphate catabolic process (GO:0046386)2.94043461
65protoporphyrinogen IX biosynthetic process (GO:0006782)2.89894416
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89874668
67heme biosynthetic process (GO:0006783)2.88828637
68positive T cell selection (GO:0043368)2.87921243
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86362374
70formation of translation preinitiation complex (GO:0001731)2.85607599
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84235304
72antigen processing and presentation of endogenous antigen (GO:0019883)2.82032425
73erythrocyte maturation (GO:0043249)2.79960190
74purinergic nucleotide receptor signaling pathway (GO:0035590)2.79014800
75regulation of B cell apoptotic process (GO:0002902)2.78237372
762-deoxyribonucleotide metabolic process (GO:0009394)2.77825522
77macromolecular complex disassembly (GO:0032984)2.77637773
78negative T cell selection (GO:0043383)2.77331887
79cellular response to ATP (GO:0071318)2.76402489
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75744951
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75744951
82megakaryocyte development (GO:0035855)2.75654567
83nuclear-transcribed mRNA catabolic process (GO:0000956)2.75487622
84proteasome assembly (GO:0043248)2.75382509
85cytochrome complex assembly (GO:0017004)2.73984714
86ubiquinone biosynthetic process (GO:0006744)2.71815554
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71286712
88regulation of T-helper 1 cell differentiation (GO:0045625)2.70107346
89DNA unwinding involved in DNA replication (GO:0006268)2.69764095
90regulation of defense response to virus by host (GO:0050691)2.68062254
91translation (GO:0006412)2.65302745
92ribonucleoprotein complex biogenesis (GO:0022613)2.65171452
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.64960722
94ribosomal large subunit biogenesis (GO:0042273)2.64608483
95mRNA catabolic process (GO:0006402)2.64126570
96oxygen transport (GO:0015671)2.63905862
97immunoglobulin mediated immune response (GO:0016064)2.61775538
98RNA catabolic process (GO:0006401)2.61653163
99positive regulation of antigen processing and presentation (GO:0002579)2.60811709
100negative regulation of lymphocyte apoptotic process (GO:0070229)2.60565229
101respiratory chain complex IV assembly (GO:0008535)2.59490686
102mast cell activation involved in immune response (GO:0002279)2.59367497
103mast cell degranulation (GO:0043303)2.59367497
104regulation of T cell mediated cytotoxicity (GO:0001914)2.59214923
105telomere maintenance (GO:0000723)2.58129582
106B cell mediated immunity (GO:0019724)2.57577230
107regulation of B cell receptor signaling pathway (GO:0050855)2.57533369
108pseudouridine synthesis (GO:0001522)2.57442523
109UV protection (GO:0009650)2.56793157
110telomere organization (GO:0032200)2.56081037
111pyrimidine nucleoside catabolic process (GO:0046135)2.55911494
112regulation of skeletal muscle contraction (GO:0014819)2.55337300
113thymic T cell selection (GO:0045061)2.54854501
114kinetochore organization (GO:0051383)2.54766048
115CENP-A containing nucleosome assembly (GO:0034080)2.54696862
116viral mRNA export from host cell nucleus (GO:0046784)2.54111711
117rRNA processing (GO:0006364)2.53957070
118regulation of B cell differentiation (GO:0045577)2.53125655
119protein localization to chromosome, centromeric region (GO:0071459)2.51394581
120NIK/NF-kappaB signaling (GO:0038061)2.50887886
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50399160
122purine nucleotide salvage (GO:0032261)2.50296567
123regulation of vacuole organization (GO:0044088)2.49960266
124pyrimidine nucleotide catabolic process (GO:0006244)2.49521551
125tRNA modification (GO:0006400)2.49390260
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.48877164
127protein complex biogenesis (GO:0070271)2.48674588
128G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.48420955
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48151485
130transcription-coupled nucleotide-excision repair (GO:0006283)2.47351965
131regulation of memory T cell differentiation (GO:0043380)2.46728030
132rRNA metabolic process (GO:0016072)2.46370314
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45774221
134DNA replication-independent nucleosome assembly (GO:0006336)2.45770581
135DNA replication-independent nucleosome organization (GO:0034724)2.45770581
136exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45213770
137chromatin remodeling at centromere (GO:0031055)2.44953698
138negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44739881
139deoxyribose phosphate metabolic process (GO:0019692)2.43938980
140AMP metabolic process (GO:0046033)2.43713083
141mast cell activation (GO:0045576)2.42245323
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.41842997
143termination of RNA polymerase III transcription (GO:0006386)2.41842997
144positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.41832032
145regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.41447974
146cellular metabolic compound salvage (GO:0043094)2.41210255
147ADP metabolic process (GO:0046031)2.41058212
148negative regulation of T cell apoptotic process (GO:0070233)2.40251242
149porphyrin-containing compound biosynthetic process (GO:0006779)2.39734682
150leukocyte degranulation (GO:0043299)2.36678247
151granulocyte differentiation (GO:0030851)2.36457357
152regulation of T cell receptor signaling pathway (GO:0050856)2.36451231
153adenosine receptor signaling pathway (GO:0001973)2.36314207
154negative regulation of innate immune response (GO:0045824)2.36112957
155positive regulation of granulocyte differentiation (GO:0030854)2.35672013
156mature B cell differentiation involved in immune response (GO:0002313)2.35278392
157embryonic hemopoiesis (GO:0035162)2.35086756
158regulation of gamma-delta T cell activation (GO:0046643)2.35012261
159positive regulation of T cell differentiation in thymus (GO:0033089)2.34256673
160kinetochore assembly (GO:0051382)2.34121349
161translesion synthesis (GO:0019985)2.34111684
162heme metabolic process (GO:0042168)2.33939027
163regulation of T-helper 2 cell differentiation (GO:0045628)2.33499721
164negative regulation of phagocytosis (GO:0050765)2.33183424
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.32673184
166antigen processing and presentation via MHC class Ib (GO:0002475)2.32284919
167erythrocyte development (GO:0048821)2.31352861
168attachment of spindle microtubules to kinetochore (GO:0008608)2.31204367
169protein localization to kinetochore (GO:0034501)2.30979829
170ncRNA 3-end processing (GO:0043628)2.30891863
171antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.28983409
172negative regulation of RNA splicing (GO:0033119)2.28638669
173protein targeting to membrane (GO:0006612)2.28537785
174cellular response to zinc ion (GO:0071294)2.28126735
175termination of RNA polymerase II transcription (GO:0006369)2.27552562
1763-UTR-mediated mRNA stabilization (GO:0070935)2.27232622
177base-excision repair (GO:0006284)2.26285614
178regulation of gamma-delta T cell differentiation (GO:0045586)2.26097813
179spliceosomal snRNP assembly (GO:0000387)2.25987429
180DNA-dependent DNA replication (GO:0006261)2.25783128
181iron-sulfur cluster assembly (GO:0016226)2.25606801
182metallo-sulfur cluster assembly (GO:0031163)2.25606801
183antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.25250490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40975638
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56476161
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.79632253
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63018943
5* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62352673
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.56427413
7* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54008073
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53036893
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48783209
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40638132
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39333503
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.38226428
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37303020
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34763555
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.32210072
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29680408
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27111285
18MYC_22102868_ChIP-Seq_BL_Human2.26541108
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.23132895
20SCL_19346495_ChIP-Seq_HPC-7_Human2.22128979
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20675510
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17636476
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17560156
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17146887
25* ETS1_20019798_ChIP-Seq_JURKAT_Human2.17114255
26VDR_21846776_ChIP-Seq_THP-1_Human2.15956672
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.15529927
28VDR_23849224_ChIP-Seq_CD4+_Human2.07911536
29BCL6_27268052_Chip-Seq_Bcells_Human2.07533824
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07459874
31P68_20966046_ChIP-Seq_HELA_Human2.06929008
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00507362
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.99002590
34LXR_22292898_ChIP-Seq_THP-1_Human1.97906197
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97393385
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94179945
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91679192
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88124691
39BCOR_27268052_Chip-Seq_Bcells_Human1.88100233
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83568629
41* XRN2_22483619_ChIP-Seq_HELA_Human1.82885402
42FOXP3_21729870_ChIP-Seq_TREG_Human1.82011530
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81513808
44CIITA_25753668_ChIP-Seq_RAJI_Human1.81308235
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80899906
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.78891544
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.78388352
48SPI1_23547873_ChIP-Seq_NB4_Human1.78386659
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77874013
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.74169869
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68768329
52E2F1_20622854_ChIP-Seq_HELA_Human1.65665069
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.62509320
54PHF8_20622854_ChIP-Seq_HELA_Human1.62054873
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61698451
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60602046
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59899530
58* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59104243
59DCP1A_22483619_ChIP-Seq_HELA_Human1.59053363
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58578612
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.57713105
62* GABP_19822575_ChIP-Seq_HepG2_Human1.54881605
63MAF_26560356_Chip-Seq_TH1_Human1.53555342
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52697647
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52238639
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51010597
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50725750
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.50364863
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.49840837
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47876227
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47711567
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46980995
73* FOXP1_21924763_ChIP-Seq_HESCs_Human1.46531630
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46335416
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.44935860
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.44771130
77MYB_26560356_Chip-Seq_TH2_Human1.43158487
78TTF2_22483619_ChIP-Seq_HELA_Human1.42855404
79* RUNX1_22412390_ChIP-Seq_EML_Mouse1.41331686
80VDR_24763502_ChIP-Seq_THP-1_Human1.40869334
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.40601850
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39466310
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39204477
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.39125228
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38063641
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37182353
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36876084
88UTX_26944678_Chip-Seq_JUKART_Human1.36577206
89CTCF_20526341_ChIP-Seq_ESCs_Human1.36301188
90KDM2B_26808549_Chip-Seq_DND41_Human1.36065415
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35225552
92SA1_27219007_Chip-Seq_Bcells_Human1.34904401
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34715889
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34535377
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33902429
96MYB_26560356_Chip-Seq_TH1_Human1.33608466
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.32074944
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.31358979
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30726507
100CTCF_21964334_Chip-Seq_Bcells_Human1.30588789
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30307904
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.29941243
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28955345
104* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28935573
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.28088489
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26591481
107P300_27268052_Chip-Seq_Bcells_Human1.25508393
108SMC4_20622854_ChIP-Seq_HELA_Human1.24829298
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23742343
110CTCF_27219007_Chip-Seq_Bcells_Human1.23598508
111* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23180235
112ELK1_19687146_ChIP-ChIP_HELA_Human1.23067849
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22696119
114* MAF_26560356_Chip-Seq_TH2_Human1.21740446
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21350414
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21241410
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20359690
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19571776
119* ERA_21632823_ChIP-Seq_H3396_Human1.19319180
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18538074
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17981248
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17932925
123CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16167360
124* RARA_24833708_ChIP-Seq_LIVER_Mouse1.15518478
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15513675
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15196265
127STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14911004
128ETS1_21867929_ChIP-Seq_TH2_Mouse1.14820755
129* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13351442
130IRF8_27001747_Chip-Seq_BMDM_Mouse1.12753160
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12527165
132SPI1_20517297_ChIP-Seq_HL60_Human1.12264230
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10571212
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08619788
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07992346
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07826611
137KDM5A_27292631_Chip-Seq_BREAST_Human1.07292661
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05897257
139TCF7_22412390_ChIP-Seq_EML_Mouse1.05845839
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05345971
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05134001
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02668940
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02242303
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01290434
145GATA1_19941827_ChIP-Seq_MEL_Mouse1.01266957
146* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00809704
147GATA1_22025678_ChIP-Seq_K562_Human1.00515589
148AR_21909140_ChIP-Seq_LNCAP_Human0.99629212
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97747683
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97221196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.62399101
2MP0003693_abnormal_embryo_hatching3.54456869
3MP0001835_abnormal_antigen_presentation3.29468044
4MP0002396_abnormal_hematopoietic_system3.12914981
5MP0010094_abnormal_chromosome_stability2.77534989
6MP0008057_abnormal_DNA_replication2.70417792
7MP0000685_abnormal_immune_system2.70006595
8MP0005671_abnormal_response_to2.68464452
9MP0003763_abnormal_thymus_physiology2.66985754
10MP0003656_abnormal_erythrocyte_physiolo2.64526952
11MP0003111_abnormal_nucleus_morphology2.62721688
12MP0001545_abnormal_hematopoietic_system2.45631062
13MP0005397_hematopoietic_system_phenotyp2.45631062
14MP0003077_abnormal_cell_cycle2.36577746
15MP0002398_abnormal_bone_marrow2.31507675
16MP0009333_abnormal_splenocyte_physiolog2.30860471
17MP0001800_abnormal_humoral_immune2.29939746
18MP0008058_abnormal_DNA_repair2.29674022
19MP0004381_abnormal_hair_follicle2.24627651
20MP0009785_altered_susceptibility_to2.16342447
21MP0004957_abnormal_blastocyst_morpholog2.09392449
22MP0002452_abnormal_antigen_presenting2.07464320
23MP0002420_abnormal_adaptive_immunity2.06595279
24MP0005000_abnormal_immune_tolerance2.05499280
25MP0001819_abnormal_immune_cell2.04347386
26MP0005025_abnormal_response_to2.03471983
27MP0002723_abnormal_immune_serum2.00116571
28MP0005387_immune_system_phenotype1.99629015
29MP0001790_abnormal_immune_system1.99629015
30MP0000490_abnormal_crypts_of1.99345137
31MP0003436_decreased_susceptibility_to1.99307577
32MP0000689_abnormal_spleen_morphology1.97120016
33MP0004147_increased_porphyrin_level1.95605200
34MP0002722_abnormal_immune_system1.94223511
35MP0000716_abnormal_immune_system1.90663142
36MP0002148_abnormal_hypersensitivity_rea1.90194601
37MP0004808_abnormal_hematopoietic_stem1.85414073
38MP0003878_abnormal_ear_physiology1.83065357
39MP0005377_hearing/vestibular/ear_phenot1.83065357
40MP0002405_respiratory_system_inflammati1.83051319
41MP0002429_abnormal_blood_cell1.82241087
42MP0008007_abnormal_cellular_replicative1.82090102
43MP0005360_urolithiasis1.74119134
44MP0002419_abnormal_innate_immunity1.73030577
45MP0000703_abnormal_thymus_morphology1.71037524
46MP0005075_abnormal_melanosome_morpholog1.69366834
47MP0003646_muscle_fatigue1.68237274
48MP0002132_abnormal_respiratory_system1.66759080
49MP0006054_spinal_hemorrhage1.65678489
50MP0002166_altered_tumor_susceptibility1.61390320
51MP0002653_abnormal_ependyma_morphology1.61241526
52MP0005464_abnormal_platelet_physiology1.61009403
53MP0003724_increased_susceptibility_to1.59387838
54MP0000465_gastrointestinal_hemorrhage1.56967915
55MP0001853_heart_inflammation1.49753173
56MP0010155_abnormal_intestine_physiology1.48983913
57MP0005451_abnormal_body_composition1.44385392
58MP0009278_abnormal_bone_marrow1.44183530
59MP0005171_absent_coat_pigmentation1.41608980
60MP0005174_abnormal_tail_pigmentation1.40826518
61MP0001188_hyperpigmentation1.40554082
62MP0001873_stomach_inflammation1.39294690
63MP0005330_cardiomyopathy1.38850892
64MP0003136_yellow_coat_color1.37480728
65MP0003172_abnormal_lysosome_physiology1.37324360
66MP0002019_abnormal_tumor_incidence1.37289652
67MP0003786_premature_aging1.37129564
68MP0002277_abnormal_respiratory_mucosa1.33137647
69MP0005083_abnormal_biliary_tract1.32330940
70MP0001845_abnormal_inflammatory_respons1.26852885
71MP0000313_abnormal_cell_death1.24754868
72MP0002837_dystrophic_cardiac_calcinosis1.23020767
73MP0002006_tumorigenesis1.19423303
74MP0000858_altered_metastatic_potential1.17818621
75MP0006035_abnormal_mitochondrial_morpho1.15516916
76MP0003866_abnormal_defecation1.14332690
77MP0002095_abnormal_skin_pigmentation1.14002719
78MP0001905_abnormal_dopamine_level1.13502560
79MP0005410_abnormal_fertilization1.09815777
80MP0006082_CNS_inflammation1.09070791
81MP0000350_abnormal_cell_proliferation1.08859709
82MP0005423_abnormal_somatic_nervous1.07545154
83MP0008932_abnormal_embryonic_tissue1.06910499
84MP0008469_abnormal_protein_level1.04010816
85MP0008260_abnormal_autophagy1.00542071
86MP0001968_abnormal_touch/_nociception0.95473878
87MP0004947_skin_inflammation0.91674227
88MP0002693_abnormal_pancreas_physiology0.90804055
89MP0005166_decreased_susceptibility_to0.90759678
90MP0008877_abnormal_DNA_methylation0.90353696
91MP0000015_abnormal_ear_pigmentation0.90138812
92MP0010307_abnormal_tumor_latency0.89634875
93MP0003303_peritoneal_inflammation0.89250746
94MP0000749_muscle_degeneration0.87470156
95MP0009764_decreased_sensitivity_to0.87234779
96MP0003186_abnormal_redox_activity0.86036701
97MP0006036_abnormal_mitochondrial_physio0.84348080
98MP0001533_abnormal_skeleton_physiology0.83548414
99MP0001929_abnormal_gametogenesis0.82552403
100MP0005084_abnormal_gallbladder_morpholo0.81698935
101MP0001730_embryonic_growth_arrest0.80846361
102MP0000678_abnormal_parathyroid_gland0.80333738
103MP0001765_abnormal_ion_homeostasis0.79172114
104MP0001502_abnormal_circadian_rhythm0.75469207
105MP0001756_abnormal_urination0.75037494
106MP0003011_delayed_dark_adaptation0.74876727
107MP0000358_abnormal_cell_content/0.74212072
108MP0002933_joint_inflammation0.73661830
109MP0001986_abnormal_taste_sensitivity0.73425932
110MP0000750_abnormal_muscle_regeneration0.73209365
111MP0002138_abnormal_hepatobiliary_system0.72955006
112MP0002210_abnormal_sex_determination0.72592830
113MP0003448_altered_tumor_morphology0.71034723
114MP0000343_altered_response_to0.70229514
115MP0008004_abnormal_stomach_pH0.69739338
116MP0009643_abnormal_urine_homeostasis0.68938198
117MP0003943_abnormal_hepatobiliary_system0.68559511
118MP0003828_pulmonary_edema0.67427315
119MP0003075_altered_response_to0.66684442
120MP0000013_abnormal_adipose_tissue0.66332887
121MP0005584_abnormal_enzyme/coenzyme_acti0.65984531
122MP0003191_abnormal_cellular_cholesterol0.65965947
123MP0002080_prenatal_lethality0.65853086
124MP0009931_abnormal_skin_appearance0.60724414
125MP0001145_abnormal_male_reproductive0.60692653
126MP0005310_abnormal_salivary_gland0.58808406
127MP0009840_abnormal_foam_cell0.57697942
128MP0000477_abnormal_intestine_morphology0.55112256
129MP0001663_abnormal_digestive_system0.54953684
130MP0001764_abnormal_homeostasis0.54906514
131MP0004510_myositis0.54726940
132MP0001697_abnormal_embryo_size0.54585929
133MP0008995_early_reproductive_senescence0.54129502
134MP0003183_abnormal_peptide_metabolism0.53009739
135MP0003300_gastrointestinal_ulcer0.52382840
136MP0005058_abnormal_lysosome_morphology0.51680727
137MP0009379_abnormal_foot_pigmentation0.51604617
138MP0003567_abnormal_fetal_cardiomyocyte0.51250224

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.49853537
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35822331
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.75800886
4Reticulocytopenia (HP:0001896)4.32866082
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.22671894
6Increased muscle lipid content (HP:0009058)4.09952594
7Increased intramyocellular lipid droplets (HP:0012240)3.84067718
8Hepatocellular necrosis (HP:0001404)3.79569078
9Petechiae (HP:0000967)3.75812665
10Recurrent abscess formation (HP:0002722)3.70669521
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56491283
12Thrombocytosis (HP:0001894)3.52049925
13IgM deficiency (HP:0002850)3.50433159
14Mitochondrial inheritance (HP:0001427)3.33377678
15Recurrent bronchitis (HP:0002837)3.30296497
16Hepatic necrosis (HP:0002605)3.29437487
17Stomatitis (HP:0010280)3.27761524
18Aplastic anemia (HP:0001915)3.21171549
19Pallor (HP:0000980)3.19439876
20Rib fusion (HP:0000902)3.18141254
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.17867782
22Birth length less than 3rd percentile (HP:0003561)3.15462965
23Testicular atrophy (HP:0000029)3.13447017
24Abnormal mitochondria in muscle tissue (HP:0008316)3.12578601
25Renal Fanconi syndrome (HP:0001994)3.05587372
26Recurrent bacterial skin infections (HP:0005406)3.01810420
27Chronic otitis media (HP:0000389)3.01410806
28Agammaglobulinemia (HP:0004432)2.99632790
29Elevated erythrocyte sedimentation rate (HP:0003565)2.97877379
30Prolonged bleeding time (HP:0003010)2.91066650
31Panhypogammaglobulinemia (HP:0003139)2.89739932
32Recurrent viral infections (HP:0004429)2.89360764
33Increased CSF lactate (HP:0002490)2.89175994
34Methylmalonic aciduria (HP:0012120)2.87091574
35Abnormality of the nasal mucosa (HP:0000433)2.85612868
36Lipid accumulation in hepatocytes (HP:0006561)2.83856228
37Ragged-red muscle fibers (HP:0003200)2.82154446
38Abnormality of the preputium (HP:0100587)2.81870050
39Macrocytic anemia (HP:0001972)2.80318990
40Nasal polyposis (HP:0100582)2.78736614
41Myopathic facies (HP:0002058)2.77704537
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72085709
43Dicarboxylic aciduria (HP:0003215)2.72085709
44Pustule (HP:0200039)2.71839742
45Acute necrotizing encephalopathy (HP:0006965)2.71348612
46Poikilocytosis (HP:0004447)2.69388683
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.62995601
48Myelodysplasia (HP:0002863)2.62621403
49Abnormality of T cells (HP:0002843)2.61721265
50Recurrent fungal infections (HP:0002841)2.61013341
51Abnormality of reticulocytes (HP:0004312)2.60974813
52Severe visual impairment (HP:0001141)2.56154983
53Meningitis (HP:0001287)2.54511674
54Abnormality of T cell physiology (HP:0011840)2.52451079
55Chromsome breakage (HP:0040012)2.51037084
56Type I transferrin isoform profile (HP:0003642)2.50400209
57Lymphoma (HP:0002665)2.49621513
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47262833
59Recurrent sinusitis (HP:0011108)2.45705023
60Eosinophilia (HP:0001880)2.45599329
61Eczematoid dermatitis (HP:0000976)2.45281812
62Gastrointestinal inflammation (HP:0004386)2.43741430
63Exercise intolerance (HP:0003546)2.43686158
64Increased serum lactate (HP:0002151)2.43450190
65Abnormality of the fingertips (HP:0001211)2.42691502
66Facial diplegia (HP:0001349)2.41515420
67Inflammation of the large intestine (HP:0002037)2.40710101
68Lactic acidosis (HP:0003128)2.39652289
69Abnormality of B cell number (HP:0010975)2.39532045
70B lymphocytopenia (HP:0010976)2.39532045
71Meckel diverticulum (HP:0002245)2.38852243
72Exertional dyspnea (HP:0002875)2.37164967
73Poikiloderma (HP:0001029)2.36982782
74T lymphocytopenia (HP:0005403)2.35489175
75Progressive muscle weakness (HP:0003323)2.35250270
76Abnormality of chromosome stability (HP:0003220)2.34960140
77Microcytic anemia (HP:0001935)2.34883540
78Mediastinal lymphadenopathy (HP:0100721)2.34055405
79Increased hepatocellular lipid droplets (HP:0006565)2.33820651
80Abnormality of the ileum (HP:0001549)2.33150449
81Spontaneous hematomas (HP:0007420)2.29408507
82Rhabdomyolysis (HP:0003201)2.29105424
83Cellulitis (HP:0100658)2.28983964
84Obstructive lung disease (HP:0006536)2.28243016
85Chronic obstructive pulmonary disease (HP:0006510)2.28243016
86Bone marrow hypocellularity (HP:0005528)2.27397707
87Epistaxis (HP:0000421)2.27012946
88Abnormality of T cell number (HP:0011839)2.26418174
89Methylmalonic acidemia (HP:0002912)2.24820075
90Recurrent skin infections (HP:0001581)2.24493419
91Severe combined immunodeficiency (HP:0004430)2.24173126
92Combined immunodeficiency (HP:0005387)2.24102434
93Myositis (HP:0100614)2.22993999
94IgG deficiency (HP:0004315)2.22319007
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21218219
96Orchitis (HP:0100796)2.19197551
97Recurrent cutaneous fungal infections (HP:0011370)2.18885951
98Chronic mucocutaneous candidiasis (HP:0002728)2.18885951
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.17632087
100Progressive microcephaly (HP:0000253)2.17607031
101Acute encephalopathy (HP:0006846)2.17423655
102Absent thumb (HP:0009777)2.17303348
103Clubbing of toes (HP:0100760)2.16578177
104Pancytopenia (HP:0001876)2.16325029
105Abnormality of cells of the lymphoid lineage (HP:0012140)2.14317348
106Progressive macrocephaly (HP:0004481)2.13712115
107Muscle fiber atrophy (HP:0100295)2.11458858
108Lymphopenia (HP:0001888)2.10777923
109Hemorrhage of the eye (HP:0011885)2.10684280
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.10575452
111Bronchitis (HP:0012387)2.09160355
112Optic neuritis (HP:0100653)2.08720751
113Retrobulbar optic neuritis (HP:0100654)2.08720751
114Oral leukoplakia (HP:0002745)2.07096631
11511 pairs of ribs (HP:0000878)2.07047020
116Reduced antithrombin III activity (HP:0001976)2.06656337
117Hypochromic anemia (HP:0001931)2.05995936
118Mesangial abnormality (HP:0001966)2.05993815
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05760734
120Abnormal protein N-linked glycosylation (HP:0012347)2.05760734
121Abnormal protein glycosylation (HP:0012346)2.05760734
122Abnormal glycosylation (HP:0012345)2.05760734
123Congenital stationary night blindness (HP:0007642)2.04440642
124Cutaneous photosensitivity (HP:0000992)2.01738513
125Type 2 muscle fiber atrophy (HP:0003554)2.00411983
126Recurrent pneumonia (HP:0006532)1.99788543
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98542784
128Neutropenia (HP:0001875)1.98325810
129Recurrent lower respiratory tract infections (HP:0002783)1.97523142
130Colitis (HP:0002583)1.96836487
131Granulocytopenia (HP:0001913)1.96769321
132Leukopenia (HP:0001882)1.95831913
133Abnormality of DNA repair (HP:0003254)1.95587883
134Autoimmune thrombocytopenia (HP:0001973)1.94801649
135Increased IgE level (HP:0003212)1.94622477
136Microretrognathia (HP:0000308)1.93611644
137Encephalitis (HP:0002383)1.93459304
138Poor head control (HP:0002421)1.92947102
139Purpura (HP:0000979)1.92046746
140Bulbar palsy (HP:0001283)1.91723699
141Impaired platelet aggregation (HP:0003540)1.91174826
142Abnormal platelet function (HP:0011869)1.91174826
143Exercise-induced myalgia (HP:0003738)1.91103740
144Abnormality of the anterior horn cell (HP:0006802)1.91000170
145Degeneration of anterior horn cells (HP:0002398)1.91000170
146Abnormality of macrophages (HP:0004311)1.90585499
147Gastrointestinal infarctions (HP:0005244)1.89539781
148Abnormality of the prostate (HP:0008775)1.89134662
149Duodenal stenosis (HP:0100867)1.88719866
150Small intestinal stenosis (HP:0012848)1.88719866
151Squamous cell carcinoma (HP:0002860)1.87687903
152Abnormality of eosinophils (HP:0001879)1.87146150
153Pulmonary fibrosis (HP:0002206)1.86990518
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86621456
155Attenuation of retinal blood vessels (HP:0007843)1.86339381
156Rectal fistula (HP:0100590)1.85986434
157Rectovaginal fistula (HP:0000143)1.85986434
158Leukocytosis (HP:0001974)1.84681756
159Increased IgM level (HP:0003496)1.84468381
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.84364833
161Acute hepatic failure (HP:0006554)1.83598998
162Generalized aminoaciduria (HP:0002909)1.82510177
163Fetal akinesia sequence (HP:0001989)1.80032907
164Respiratory difficulties (HP:0002880)1.79100868
165Hypertensive crisis (HP:0100735)1.78509059
166Ketosis (HP:0001946)1.77665613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.81548151
2STK163.17343246
3PINK13.15988089
4VRK22.93959307
5NME22.84690984
6BUB12.46694834
7BCKDK2.25650582
8IRAK42.17021980
9WEE12.13519997
10ARAF2.08011293
11NEK22.07005791
12PIM22.05431111
13TXK2.02945663
14CDC71.97614691
15BLK1.96794549
16VRK11.92591825
17SIK21.84044922
18STK101.83568639
19BTK1.79667847
20TLK11.79267958
21ZAP701.74407502
22EIF2AK11.73524988
23TEC1.71186871
24TBK11.68584651
25TGFBR21.64140499
26SRPK11.60532341
27STK41.57794218
28DYRK31.54850800
29KDR1.52372604
30KIT1.49257107
31IKBKE1.46130148
32MAPKAPK31.40825692
33MAP3K101.40668309
34ACVR1B1.40356858
35RPS6KA41.37795075
36IKBKB1.35856493
37TYK21.34696481
38OBSCN1.33700544
39TESK21.33483929
40JAK31.32901882
41FES1.30511489
42MAP3K141.27686015
43CLK11.26023604
44ERN11.25759905
45MAP3K131.25025813
46CDK71.20240725
47CSF1R1.20175378
48SYK1.20125538
49PIM11.19002339
50BRSK21.18710710
51MAP3K111.16604492
52LRRK21.16069792
53MOS1.15148121
54MAP3K11.14554534
55IRAK31.12315835
56ABL21.09525596
57ATR1.06756250
58CDK41.06106904
59CDK121.03805120
60IRAK21.03548474
61ITK1.02450833
62ZAK1.00999191
63PLK41.00190897
64MAP2K30.97847087
65MAPK150.96232679
66GRK60.91643127
67TAOK10.91635173
68PRKCQ0.90316896
69NLK0.89941035
70LYN0.88927948
71EPHB10.87947868
72PLK10.86702007
73AURKB0.86129950
74CSNK1G30.84523502
75MAP2K60.84254615
76BRSK10.83634216
77PHKG20.82873546
78PHKG10.82873546
79TNK20.82307664
80CHUK0.81908144
81MUSK0.81199624
82LCK0.80539572
83TGFBR10.80145856
84MAP3K80.79399305
85MKNK10.79314703
86EEF2K0.77506019
87FLT30.77090324
88NUAK10.75542635
89CCNB10.75402555
90CHEK20.75258371
91RPS6KA50.74588429
92PDK20.74331929
93EIF2AK30.71907868
94TAOK30.70219089
95MAPK120.69494811
96PRKCI0.68812449
97MAP2K20.67886982
98TAOK20.62926178
99TESK10.61559663
100RPS6KB20.59193975
101PAK10.58461893
102EIF2AK20.58404455
103MKNK20.58126802
104CSNK1G10.57546233
105RPS6KA60.57545934
106PKN20.57536036
107SIK30.56646408
108MAPKAPK20.56074270
109MAPK110.55777896
110IRAK10.53464976
111CSK0.51467873
112DAPK10.50985600
113MAPKAPK50.50770044
114MST40.50650306
115YES10.50413359
116HCK0.50217702
117HIPK20.50173260
118CSNK1G20.50165882
119BRAF0.50143800
120PDPK10.49806253
121RPS6KC10.49258048
122RPS6KL10.49258048
123AURKA0.47653673
124ILK0.47612179
125CSNK2A10.46649987
126DYRK20.46296183
127SIK10.46203173
128CHEK10.45866867
129PASK0.45275131
130CSNK1A1L0.43414175
131DYRK1B0.43082725
132TSSK60.42732489
133TTK0.41652480
134CDK80.41321713
135CSNK2A20.39604776
136ATM0.39499514
137LIMK10.39151435
138PRKD20.38892457
139AKT20.38889918
140MARK30.38801400
141PDK10.38617155
142MAPK40.37041520
143GRK10.36311526
144RPS6KA10.32185408
145CDK90.31384591
146CDK190.31380519
147BMX0.29437825
148ADRBK20.28019466
149CDK30.27851644

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57863266
2Ribosome_Homo sapiens_hsa030103.78029789
3Mismatch repair_Homo sapiens_hsa034303.51632049
4Base excision repair_Homo sapiens_hsa034103.24145013
5Homologous recombination_Homo sapiens_hsa034402.74028488
6RNA polymerase_Homo sapiens_hsa030202.60016335
7Spliceosome_Homo sapiens_hsa030402.58414822
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53079996
9Oxidative phosphorylation_Homo sapiens_hsa001902.45284997
10Primary immunodeficiency_Homo sapiens_hsa053402.43030937
11Proteasome_Homo sapiens_hsa030502.33047983
12Nucleotide excision repair_Homo sapiens_hsa034202.30811094
13Pyrimidine metabolism_Homo sapiens_hsa002402.24734057
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06551428
15Fanconi anemia pathway_Homo sapiens_hsa034602.06046081
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02187026
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.82601436
18Non-homologous end-joining_Homo sapiens_hsa034501.82261657
19Cell cycle_Homo sapiens_hsa041101.80866682
20RNA transport_Homo sapiens_hsa030131.73527716
21Antigen processing and presentation_Homo sapiens_hsa046121.73336492
22Type I diabetes mellitus_Homo sapiens_hsa049401.57638985
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.50632059
24Herpes simplex infection_Homo sapiens_hsa051681.48692937
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43969269
26Fructose and mannose metabolism_Homo sapiens_hsa000511.41376896
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.38513055
28RNA degradation_Homo sapiens_hsa030181.37278277
29Measles_Homo sapiens_hsa051621.34825638
30Hematopoietic cell lineage_Homo sapiens_hsa046401.33390842
31Leishmaniasis_Homo sapiens_hsa051401.31382830
32Basal transcription factors_Homo sapiens_hsa030221.30570180
33Alzheimers disease_Homo sapiens_hsa050101.27417738
34One carbon pool by folate_Homo sapiens_hsa006701.25696738
35Systemic lupus erythematosus_Homo sapiens_hsa053221.25680031
36Protein export_Homo sapiens_hsa030601.25423247
37B cell receptor signaling pathway_Homo sapiens_hsa046621.24920413
38p53 signaling pathway_Homo sapiens_hsa041151.23166698
39Purine metabolism_Homo sapiens_hsa002301.18907509
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15863792
41Epstein-Barr virus infection_Homo sapiens_hsa051691.15811448
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99220021
43Legionellosis_Homo sapiens_hsa051340.99024604
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97306274
45Other glycan degradation_Homo sapiens_hsa005110.97029075
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95596073
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92954516
48Osteoclast differentiation_Homo sapiens_hsa043800.92484395
49Allograft rejection_Homo sapiens_hsa053300.92017767
50Sulfur relay system_Homo sapiens_hsa041220.91846668
51Rheumatoid arthritis_Homo sapiens_hsa053230.91304424
52mRNA surveillance pathway_Homo sapiens_hsa030150.89023268
53Apoptosis_Homo sapiens_hsa042100.88465278
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87834179
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86791339
56Pentose phosphate pathway_Homo sapiens_hsa000300.85725441
57Graft-versus-host disease_Homo sapiens_hsa053320.84915906
58Acute myeloid leukemia_Homo sapiens_hsa052210.81733071
59Influenza A_Homo sapiens_hsa051640.81480260
60Shigellosis_Homo sapiens_hsa051310.81411756
61Viral carcinogenesis_Homo sapiens_hsa052030.81222459
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80625371
63Lysosome_Homo sapiens_hsa041420.80316402
64Phagosome_Homo sapiens_hsa041450.78373863
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.77989765
66Fatty acid elongation_Homo sapiens_hsa000620.77620766
67Hepatitis B_Homo sapiens_hsa051610.75950303
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75252455
69T cell receptor signaling pathway_Homo sapiens_hsa046600.75136163
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73415427
71Folate biosynthesis_Homo sapiens_hsa007900.72039276
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71667781
73* HTLV-I infection_Homo sapiens_hsa051660.70015012
74Malaria_Homo sapiens_hsa051440.67436693
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65333688
76Viral myocarditis_Homo sapiens_hsa054160.62700294
77Notch signaling pathway_Homo sapiens_hsa043300.61619583
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60605256
79Toxoplasmosis_Homo sapiens_hsa051450.59905235
80Pertussis_Homo sapiens_hsa051330.58980060
81N-Glycan biosynthesis_Homo sapiens_hsa005100.55615940
82Chronic myeloid leukemia_Homo sapiens_hsa052200.54432268
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53346552
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53274407
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51897534
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51180692
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.51058805
88Arachidonic acid metabolism_Homo sapiens_hsa005900.50503024
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50318473
90Tuberculosis_Homo sapiens_hsa051520.49298731
91Cardiac muscle contraction_Homo sapiens_hsa042600.49243851
92Metabolic pathways_Homo sapiens_hsa011000.48640245
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47911126
94Small cell lung cancer_Homo sapiens_hsa052220.47467790
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46630639
96Glutathione metabolism_Homo sapiens_hsa004800.46327085
97Peroxisome_Homo sapiens_hsa041460.46197914
98Endocytosis_Homo sapiens_hsa041440.45754023
99Asthma_Homo sapiens_hsa053100.45487606
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.43906056
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.42468975
102Autoimmune thyroid disease_Homo sapiens_hsa053200.42439090
103Huntingtons disease_Homo sapiens_hsa050160.42403018
104Vitamin B6 metabolism_Homo sapiens_hsa007500.42380375
105Collecting duct acid secretion_Homo sapiens_hsa049660.42148003
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41955915
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40022842
108Circadian rhythm_Homo sapiens_hsa047100.38872374
109Parkinsons disease_Homo sapiens_hsa050120.37580230
110Staphylococcus aureus infection_Homo sapiens_hsa051500.36750664
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.35050982
112Sulfur metabolism_Homo sapiens_hsa009200.34944439
113Platelet activation_Homo sapiens_hsa046110.34313381
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34076730
115Nitrogen metabolism_Homo sapiens_hsa009100.33860037
116TNF signaling pathway_Homo sapiens_hsa046680.33771554
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33422755
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33193373
119Galactose metabolism_Homo sapiens_hsa000520.31807355
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31691258
121Thyroid cancer_Homo sapiens_hsa052160.30308700
122Chemokine signaling pathway_Homo sapiens_hsa040620.29116885
123Regulation of autophagy_Homo sapiens_hsa041400.28815839
124Salmonella infection_Homo sapiens_hsa051320.27711516
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.27165624
126Pancreatic cancer_Homo sapiens_hsa052120.26556441
127Olfactory transduction_Homo sapiens_hsa047400.24185206
128Carbon metabolism_Homo sapiens_hsa012000.24045453

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