GPS2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.93252969
2cytidine metabolic process (GO:0046087)5.21319083
3cytidine catabolic process (GO:0006216)5.21319083
4cytidine deamination (GO:0009972)5.21319083
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.73556371
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.47252887
7purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.85155795
8L-fucose catabolic process (GO:0042355)3.74936784
9fucose catabolic process (GO:0019317)3.74936784
10L-fucose metabolic process (GO:0042354)3.74936784
11metallo-sulfur cluster assembly (GO:0031163)3.68091027
12iron-sulfur cluster assembly (GO:0016226)3.68091027
13positive regulation of defense response to virus by host (GO:0002230)3.64941345
14piRNA metabolic process (GO:0034587)3.62921136
15cellular response to interleukin-15 (GO:0071350)3.60791242
16tryptophan metabolic process (GO:0006568)3.49830263
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39045248
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39045248
19platelet dense granule organization (GO:0060155)3.37679618
20indole-containing compound catabolic process (GO:0042436)3.36955338
21indolalkylamine catabolic process (GO:0046218)3.36955338
22tryptophan catabolic process (GO:0006569)3.36955338
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35575124
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29235790
25deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.18088430
26purine deoxyribonucleotide metabolic process (GO:0009151)3.12700145
27chaperone mediated protein folding requiring cofactor (GO:0051085)3.11158160
28regulation of T cell receptor signaling pathway (GO:0050856)3.09625885
29sleep (GO:0030431)3.07731457
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06108667
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02175948
32negative regulation of cell killing (GO:0031342)3.02175948
33branched-chain amino acid catabolic process (GO:0009083)3.01417860
34L-methionine salvage (GO:0071267)3.00919972
35L-methionine biosynthetic process (GO:0071265)3.00919972
36amino acid salvage (GO:0043102)3.00919972
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97095133
38positive regulation of antigen processing and presentation (GO:0002579)2.94705919
39regulation of defense response to virus by host (GO:0050691)2.93874200
40actin nucleation (GO:0045010)2.93544505
41adaptation of signaling pathway (GO:0023058)2.92047222
42sequestering of actin monomers (GO:0042989)2.91080054
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89962596
44regulation of gamma-delta T cell differentiation (GO:0045586)2.87621121
45protein-cofactor linkage (GO:0018065)2.87325340
46negative regulation of T cell apoptotic process (GO:0070233)2.86496482
47indolalkylamine metabolic process (GO:0006586)2.84610005
48negative regulation of thymocyte apoptotic process (GO:0070244)2.83529118
49positive regulation of T-helper 1 type immune response (GO:0002827)2.83052079
50S-adenosylmethionine metabolic process (GO:0046500)2.81707285
51antigen processing and presentation of endogenous antigen (GO:0019883)2.81373203
52mannosylation (GO:0097502)2.79639567
53organelle membrane fusion (GO:0090174)2.78794140
54DNA methylation involved in gamete generation (GO:0043046)2.78281850
55proteasome assembly (GO:0043248)2.77109454
56positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76439428
57adenosine metabolic process (GO:0046085)2.74677877
58kynurenine metabolic process (GO:0070189)2.72334451
59negative regulation of calcium ion transport into cytosol (GO:0010523)2.69705119
60response to pheromone (GO:0019236)2.67152811
61positive regulation of prostaglandin secretion (GO:0032308)2.66753511
62negative regulation of lymphocyte apoptotic process (GO:0070229)2.65740237
63regulation of B cell apoptotic process (GO:0002902)2.63625328
64autophagic vacuole fusion (GO:0000046)2.63586690
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62084317
66positive regulation of uterine smooth muscle contraction (GO:0070474)2.61161468
67negative regulation of T cell differentiation in thymus (GO:0033085)2.60402657
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60378975
69regulation of T cell mediated cytotoxicity (GO:0001914)2.57777433
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.57652289
71aggressive behavior (GO:0002118)2.56720873
72protein complex biogenesis (GO:0070271)2.54532296
73response to interleukin-15 (GO:0070672)2.51272383
74regulation of memory T cell differentiation (GO:0043380)2.50497715
75negative regulation of telomere maintenance (GO:0032205)2.50180200
76regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.50130310
77regulation of cellular amino acid metabolic process (GO:0006521)2.49735028
78purine deoxyribonucleotide catabolic process (GO:0009155)2.49658304
79negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.48185901
80regulation of leukocyte mediated cytotoxicity (GO:0001910)2.46561123
81response to gravity (GO:0009629)2.46495240
82regulation of thymocyte apoptotic process (GO:0070243)2.44918698
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44146973
84negative regulation of B cell apoptotic process (GO:0002903)2.42082155
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.41986727
86protein maturation by protein folding (GO:0022417)2.41565026
87regulation of gamma-delta T cell activation (GO:0046643)2.41311899
88regulation of chronic inflammatory response (GO:0002676)2.40978950
89regulation of T-helper 1 type immune response (GO:0002825)2.39016213
90cellular ketone body metabolic process (GO:0046950)2.38835969
91negative T cell selection (GO:0043383)2.37708844
92regulation of antigen processing and presentation (GO:0002577)2.37385589
93pyrimidine nucleoside catabolic process (GO:0046135)2.36621707
94protein deneddylation (GO:0000338)2.35579448
95respiratory chain complex IV assembly (GO:0008535)2.35476562
96ATP synthesis coupled proton transport (GO:0015986)2.33678833
97energy coupled proton transport, down electrochemical gradient (GO:0015985)2.33678833
98water-soluble vitamin biosynthetic process (GO:0042364)2.30847792
99negative regulation of innate immune response (GO:0045824)2.30668576
100positive thymic T cell selection (GO:0045059)2.30322223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.54656626
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.54170489
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22401494
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.20392005
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91073663
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90447749
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75778961
8ZNF274_21170338_ChIP-Seq_K562_Hela2.72095713
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.71252672
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70634542
11VDR_23849224_ChIP-Seq_CD4+_Human2.53533044
12VDR_22108803_ChIP-Seq_LS180_Human2.47287701
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42725852
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41769089
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41274799
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.39500006
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.34254118
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33270063
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27657270
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.10308000
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04994287
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03131288
23FOXP3_21729870_ChIP-Seq_TREG_Human1.87852629
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78753490
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78746864
26MYB_26560356_Chip-Seq_TH2_Human1.74458236
27TP53_22573176_ChIP-Seq_HFKS_Human1.74295136
28TAF15_26573619_Chip-Seq_HEK293_Human1.72332190
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69109824
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.68492156
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67382716
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66264350
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65322106
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64659832
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61347361
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61150764
37ELK1_19687146_ChIP-ChIP_HELA_Human1.59264655
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53846874
39GATA3_26560356_Chip-Seq_TH2_Human1.52770106
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52559346
41MYC_18940864_ChIP-ChIP_HL60_Human1.50095722
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44112779
43AR_20517297_ChIP-Seq_VCAP_Human1.44031441
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43373438
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.41957560
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40137205
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.40029447
48GABP_19822575_ChIP-Seq_HepG2_Human1.38711239
49IRF1_19129219_ChIP-ChIP_H3396_Human1.38515089
50GBX2_23144817_ChIP-Seq_PC3_Human1.38367163
51RUNX_20019798_ChIP-Seq_JUKART_Human1.37364666
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36813705
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33637342
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32998748
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29579910
56CIITA_25753668_ChIP-Seq_RAJI_Human1.28949651
57GATA3_27048872_Chip-Seq_THYMUS_Human1.28740047
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28679736
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.25972264
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25972264
61NCOR_22424771_ChIP-Seq_293T_Human1.22058178
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21852860
63FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19347552
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.19144966
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18970019
66TAF2_19829295_ChIP-Seq_ESCs_Human1.16441978
67SPI1_23547873_ChIP-Seq_NB4_Human1.14405623
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13326954
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12125813
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.11994953
71DCP1A_22483619_ChIP-Seq_HELA_Human1.09495921
72STAT1_20625510_ChIP-Seq_HELA_Human1.07058298
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.07013685
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06789241
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05944162
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05807805
77IGF1R_20145208_ChIP-Seq_DFB_Human1.04240076
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01280034
79BCL6_27268052_Chip-Seq_Bcells_Human1.00989374
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00356618
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.99061981
82ERA_21632823_ChIP-Seq_H3396_Human0.98238581
83MYC_19829295_ChIP-Seq_ESCs_Human0.97418585
84MYB_26560356_Chip-Seq_TH1_Human0.97278302
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97170147
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96904780
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96801472
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96688517
89RAC3_21632823_ChIP-Seq_H3396_Human0.94372449
90ERG_20517297_ChIP-Seq_VCAP_Human0.92917509
91NANOG_20526341_ChIP-Seq_ESCs_Human0.92798396
92HOXB7_26014856_ChIP-Seq_BT474_Human0.92753536
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.92140104
94P300_27268052_Chip-Seq_Bcells_Human0.91635546
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91627987
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91182447
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89439984
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88445674
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87663253
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86401097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.88049299
2MP0005671_abnormal_response_to3.90631655
3MP0003724_increased_susceptibility_to3.16895068
4MP0008877_abnormal_DNA_methylation2.98726218
5MP0003787_abnormal_imprinting2.91999146
6MP0003806_abnormal_nucleotide_metabolis2.55521606
7MP0001835_abnormal_antigen_presentation2.37917080
8MP0005084_abnormal_gallbladder_morpholo2.33662471
9MP0006072_abnormal_retinal_apoptosis2.24783055
10MP0004147_increased_porphyrin_level2.20487093
11MP0002148_abnormal_hypersensitivity_rea2.20387807
12MP0009785_altered_susceptibility_to2.16460270
13MP0002138_abnormal_hepatobiliary_system1.98126447
14MP0005000_abnormal_immune_tolerance1.96941251
15MP0002102_abnormal_ear_morphology1.84332068
16MP0003763_abnormal_thymus_physiology1.82977459
17MP0008875_abnormal_xenobiotic_pharmacok1.82426101
18MP0001984_abnormal_olfaction1.76622974
19MP0002723_abnormal_immune_serum1.69682478
20MP0005646_abnormal_pituitary_gland1.66150073
21MP0001800_abnormal_humoral_immune1.65458698
22MP0000685_abnormal_immune_system1.63558958
23MP0002876_abnormal_thyroid_physiology1.59956984
24MP0003045_fibrosis1.58337648
25MP0002420_abnormal_adaptive_immunity1.54137555
26MP0003191_abnormal_cellular_cholesterol1.53375358
27MP0005025_abnormal_response_to1.52314950
28MP0001819_abnormal_immune_cell1.51789040
29MP0001790_abnormal_immune_system1.49968215
30MP0005387_immune_system_phenotype1.49968215
31MP0003252_abnormal_bile_duct1.49538160
32MP0010234_abnormal_vibrissa_follicle1.49159193
33MP0005377_hearing/vestibular/ear_phenot1.47221685
34MP0003878_abnormal_ear_physiology1.47221685
35MP0002452_abnormal_antigen_presenting1.46061024
36MP0004043_abnormal_pH_regulation1.43921002
37MP0005645_abnormal_hypothalamus_physiol1.42587815
38MP0003195_calcinosis1.41521161
39MP0009333_abnormal_splenocyte_physiolog1.41282734
40MP0005253_abnormal_eye_physiology1.40459026
41MP0005551_abnormal_eye_electrophysiolog1.38112726
42MP0003011_delayed_dark_adaptation1.36589691
43MP0001501_abnormal_sleep_pattern1.35247144
44MP0003786_premature_aging1.34389203
45MP0005332_abnormal_amino_acid1.30831199
46MP0001905_abnormal_dopamine_level1.30166575
47MP0003866_abnormal_defecation1.29400643
48MP0001968_abnormal_touch/_nociception1.27384630
49MP0003646_muscle_fatigue1.26691920
50MP0008872_abnormal_physiological_respon1.24369743
51MP0002139_abnormal_hepatobiliary_system1.23225959
52MP0001845_abnormal_inflammatory_respons1.22648539
53MP0002419_abnormal_innate_immunity1.21107663
54MP0002837_dystrophic_cardiac_calcinosis1.18146450
55MP0005075_abnormal_melanosome_morpholog1.18063475
56MP0003718_maternal_effect1.17898684
57MP0001764_abnormal_homeostasis1.17395300
58MP0000013_abnormal_adipose_tissue1.15055504
59MP0006082_CNS_inflammation1.14895489
60MP0009764_decreased_sensitivity_to1.10567233
61MP0000689_abnormal_spleen_morphology1.10030238
62MP0002254_reproductive_system_inflammat1.09954618
63MP0002277_abnormal_respiratory_mucosa1.09223221
64MP0002163_abnormal_gland_morphology1.09119595
65MP0001756_abnormal_urination1.09107037
66MP0009046_muscle_twitch1.09004275
67MP0002166_altered_tumor_susceptibility1.06852388
68MP0002693_abnormal_pancreas_physiology1.00897113
69MP0000716_abnormal_immune_system1.00470540
70MP0005083_abnormal_biliary_tract0.97351534
71MP0002398_abnormal_bone_marrow0.96399173
72MP0006276_abnormal_autonomic_nervous0.94879442
73MP0005410_abnormal_fertilization0.93520447
74MP0005636_abnormal_mineral_homeostasis0.93394838
75MP0002722_abnormal_immune_system0.91757818
76MP0008469_abnormal_protein_level0.91408676
77MP0002405_respiratory_system_inflammati0.91193000
78MP0002006_tumorigenesis0.89862046
79MP0000538_abnormal_urinary_bladder0.89646553
80MP0001873_stomach_inflammation0.88391463
81MP0004142_abnormal_muscle_tone0.87710081
82MP0009643_abnormal_urine_homeostasis0.86954040
83MP0009745_abnormal_behavioral_response0.86308546
84MP0002736_abnormal_nociception_after0.86206197
85MP0005165_increased_susceptibility_to0.85829428
86MP0001661_extended_life_span0.85604879
87MP0006036_abnormal_mitochondrial_physio0.84005610
88MP0010155_abnormal_intestine_physiology0.83190345
89MP0003638_abnormal_response/metabolism_0.81920953
90MP0008058_abnormal_DNA_repair0.79831179
91MP0001986_abnormal_taste_sensitivity0.79775292
92MP0005310_abnormal_salivary_gland0.78079432
93MP0003075_altered_response_to0.77775641
94MP0002877_abnormal_melanocyte_morpholog0.77448023
95MP0002429_abnormal_blood_cell0.77434116
96MP0004145_abnormal_muscle_electrophysio0.77017506
97MP0005379_endocrine/exocrine_gland_phen0.75087010
98MP0006035_abnormal_mitochondrial_morpho0.74286526
99MP0000465_gastrointestinal_hemorrhage0.73970627
100MP0010329_abnormal_lipoprotein_level0.73617436

Predicted human phenotypes

RankGene SetZ-score
1Tongue fasciculations (HP:0001308)3.69012052
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.61274113
3Decreased activity of mitochondrial respiratory chain (HP:0008972)3.61274113
4Generalized aminoaciduria (HP:0002909)3.50551304
5Congenital stationary night blindness (HP:0007642)3.48030451
6Hepatic necrosis (HP:0002605)3.47305839
7Abnormal mitochondria in muscle tissue (HP:0008316)3.47129578
8Muscle fibrillation (HP:0010546)3.40548013
9IgG deficiency (HP:0004315)3.33367307
10Methylmalonic acidemia (HP:0002912)3.29705409
11Hepatocellular necrosis (HP:0001404)3.28383647
12Acute necrotizing encephalopathy (HP:0006965)3.27978177
13Mitochondrial inheritance (HP:0001427)3.26472884
14Severe combined immunodeficiency (HP:0004430)3.26432602
15Increased CSF lactate (HP:0002490)3.25565045
16Stomatitis (HP:0010280)3.20193502
17Abolished electroretinogram (ERG) (HP:0000550)3.19984120
18Methylmalonic aciduria (HP:0012120)2.96987918
19Hypothermia (HP:0002045)2.88695222
20Type I transferrin isoform profile (HP:0003642)2.84877211
21Progressive macrocephaly (HP:0004481)2.81823229
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79313157
23T lymphocytopenia (HP:0005403)2.75885079
24Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75141244
25Dicarboxylic aciduria (HP:0003215)2.75141244
26Thyroiditis (HP:0100646)2.74054696
27Elevated erythrocyte sedimentation rate (HP:0003565)2.73721824
28Prostate neoplasm (HP:0100787)2.71306582
29Abnormality of T cell number (HP:0011839)2.67319669
30Acute encephalopathy (HP:0006846)2.63557952
31Increased muscle lipid content (HP:0009058)2.61391089
32Increased intramyocellular lipid droplets (HP:0012240)2.59245387
33Abnormality of the prostate (HP:0008775)2.59156599
34Abnormal protein N-linked glycosylation (HP:0012347)2.59108771
35Abnormal protein glycosylation (HP:0012346)2.59108771
36Abnormal glycosylation (HP:0012345)2.59108771
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59108771
38Ketosis (HP:0001946)2.58407952
39Renal cortical cysts (HP:0000803)2.57758524
40Ketoacidosis (HP:0001993)2.55930352
413-Methylglutaconic aciduria (HP:0003535)2.55488313
42Lactic acidosis (HP:0003128)2.50901027
43Lipid accumulation in hepatocytes (HP:0006561)2.48186721
44Hypoalbuminemia (HP:0003073)2.46713809
45Abnormal albumin level (HP:0012116)2.46713809
46Delayed CNS myelination (HP:0002188)2.42024075
47Cerebral edema (HP:0002181)2.39130191
48Chronic diarrhea (HP:0002028)2.38890447
49Abnormality of vitamin B metabolism (HP:0004340)2.37738344
50Increased serum lactate (HP:0002151)2.37408786
51Combined immunodeficiency (HP:0005387)2.37153134
52Lethargy (HP:0001254)2.35539119
53Opisthotonus (HP:0002179)2.29383045
54Type II lissencephaly (HP:0007260)2.29378153
55Reduced antithrombin III activity (HP:0001976)2.28024132
56Aplasia/hypoplasia of the uterus (HP:0008684)2.23519619
57Abnormality of the renal cortex (HP:0011035)2.19582627
58Attenuation of retinal blood vessels (HP:0007843)2.16183176
59Abnormality of eosinophils (HP:0001879)2.14244419
60Agitation (HP:0000713)2.13649760
61Acute hepatic failure (HP:0006554)2.08133564
62Optic neuritis (HP:0100653)2.02289619
63Retrobulbar optic neuritis (HP:0100654)2.02289619
64Abnormality of T cells (HP:0002843)2.00396964
65Pancreatic cysts (HP:0001737)2.00266950
66Hypomagnesemia (HP:0002917)1.99785930
67Respiratory failure (HP:0002878)1.99180757
68Retinal dysplasia (HP:0007973)1.99121517
69Lissencephaly (HP:0001339)1.97247680
70Severe muscular hypotonia (HP:0006829)1.96538395
71Pancreatitis (HP:0001733)1.95704224
72Abnormality of fatty-acid metabolism (HP:0004359)1.94531886
73Increased hepatocellular lipid droplets (HP:0006565)1.93305616
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.90966406
75Myositis (HP:0100614)1.89760455
76Abnormality of liposaccharide metabolism (HP:0010968)1.88467514
77Abnormality of glycosphingolipid metabolism (HP:0004343)1.88467514
78Abnormality of glycolipid metabolism (HP:0010969)1.88467514
79Oligomenorrhea (HP:0000876)1.87694530
80Medial flaring of the eyebrow (HP:0010747)1.87622784
81Optic disc pallor (HP:0000543)1.87451837
82Progressive microcephaly (HP:0000253)1.86452101
83Hypoproteinemia (HP:0003075)1.81721109
84Glycosuria (HP:0003076)1.81414272
85Abnormality of urine glucose concentration (HP:0011016)1.81414272
86Inability to walk (HP:0002540)1.80109477
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79381230
88Facial diplegia (HP:0001349)1.79132425
89Pachygyria (HP:0001302)1.78418652
90Anorexia (HP:0002039)1.76514066
91Exercise intolerance (HP:0003546)1.75754596
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75697549
93Abnormality of alanine metabolism (HP:0010916)1.75697549
94Hyperalaninemia (HP:0003348)1.75697549
95Progressive inability to walk (HP:0002505)1.74421369
96Renal Fanconi syndrome (HP:0001994)1.74352491
97Failure to thrive in infancy (HP:0001531)1.73449320
98Abnormality of magnesium homeostasis (HP:0004921)1.72879355
99Orchitis (HP:0100796)1.72517876
100Hemiparesis (HP:0001269)1.72142579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.86188080
2TAOK34.34235193
3BCKDK3.54269665
4MAP4K23.45891109
5TXK3.18503775
6KDR2.82514989
7GRK12.57270579
8LIMK12.20081789
9TESK12.20008153
10VRK22.17430700
11FRK2.06442826
12ZAK2.05823652
13MAP3K141.93448401
14EIF2AK31.87737322
15MST41.82282473
16ADRBK21.75940136
17MAP2K21.64327702
18GRK61.63425875
19TLK11.59110375
20MAPKAPK31.57430657
21FES1.45447107
22ITK1.43430556
23PHKG11.37287124
24PHKG21.37287124
25OXSR11.36736072
26NUAK11.33776533
27IKBKB1.29281852
28PINK11.25046194
29PRKCQ1.18255283
30BUB11.12695922
31BMPR1B1.04512313
32SIK31.04007777
33MAP4K11.02992631
34CSNK1G10.98604642
35CSNK1G30.98014736
36RPS6KA50.97395451
37MAP3K120.97020571
38MAPKAPK50.96513622
39TBK10.94240179
40DAPK10.93944222
41MAP3K110.90552741
42CDK190.88887859
43KIT0.87836597
44SYK0.87278629
45IKBKE0.83961026
46SCYL20.83864876
47MUSK0.83645112
48ARAF0.83425771
49WNK40.82711635
50BMPR20.77249683
51TEC0.75974385
52INSRR0.73733510
53SRPK10.69737534
54STK390.68907243
55PRKCI0.68459818
56SIK20.66718399
57MATK0.66263587
58DAPK20.66097287
59TNK20.65385617
60CSNK1G20.64820990
61TIE10.64586753
62CSNK1A1L0.63980370
63ERBB30.60380054
64VRK10.58776518
65BTK0.58002856
66LCK0.57099004
67TAOK20.55658913
68IRAK40.53441051
69PIM20.52785763
70LYN0.52539878
71FLT30.52240144
72JAK30.51674247
73FER0.50029967
74CSK0.48692017
75MAP2K70.46331419
76PAK60.45048761
77DYRK20.44672443
78TRIM280.44398426
79ADRBK10.43934756
80PRKCE0.41931641
81HCK0.41752081
82GRK70.41069344
83BCR0.40615322
84STK160.38558015
85MAP2K60.36780067
86PASK0.35282974
87MAP3K130.34691832
88PRKCG0.32876992
89PAK30.32562782
90CDK30.31938235
91CHUK0.31641089
92CCNB10.31216720
93CAMK2A0.30845151
94TSSK60.30721911
95MAPK110.29271547
96PRKCA0.28055724
97MYLK0.27534564
98TAOK10.27243651
99TAF10.27100972
100IGF1R0.26992512

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.12194461
2Phototransduction_Homo sapiens_hsa047442.95738850
3Primary immunodeficiency_Homo sapiens_hsa053402.82397070
4Oxidative phosphorylation_Homo sapiens_hsa001902.54526631
5Graft-versus-host disease_Homo sapiens_hsa053322.52007210
6Type I diabetes mellitus_Homo sapiens_hsa049402.38994156
7Autoimmune thyroid disease_Homo sapiens_hsa053202.30149386
8Allograft rejection_Homo sapiens_hsa053302.27833795
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.19956523
10Fatty acid elongation_Homo sapiens_hsa000622.12394338
11Asthma_Homo sapiens_hsa053102.11255493
12Protein export_Homo sapiens_hsa030602.03593454
13Parkinsons disease_Homo sapiens_hsa050122.02832856
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99862529
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88073847
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81369497
17Antigen processing and presentation_Homo sapiens_hsa046121.76827953
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72137999
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.69568309
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61815244
21Rheumatoid arthritis_Homo sapiens_hsa053231.61614719
22Tryptophan metabolism_Homo sapiens_hsa003801.58266330
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57169855
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54427460
25RNA polymerase_Homo sapiens_hsa030201.52801928
26Sulfur metabolism_Homo sapiens_hsa009201.44817110
27Selenocompound metabolism_Homo sapiens_hsa004501.38706346
28Propanoate metabolism_Homo sapiens_hsa006401.34767428
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32428357
30Peroxisome_Homo sapiens_hsa041461.30250994
31Butanoate metabolism_Homo sapiens_hsa006501.29734219
32Alzheimers disease_Homo sapiens_hsa050101.25839792
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23346470
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18466183
35Linoleic acid metabolism_Homo sapiens_hsa005911.18053732
36Regulation of autophagy_Homo sapiens_hsa041401.16259949
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14893016
38Base excision repair_Homo sapiens_hsa034101.14017544
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14003315
40Hematopoietic cell lineage_Homo sapiens_hsa046401.12938859
41Purine metabolism_Homo sapiens_hsa002301.11812419
42Homologous recombination_Homo sapiens_hsa034401.11207254
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.05504421
44Folate biosynthesis_Homo sapiens_hsa007901.05071532
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03647734
46Huntingtons disease_Homo sapiens_hsa050161.03005277
47Collecting duct acid secretion_Homo sapiens_hsa049660.95526573
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90306611
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88931347
50One carbon pool by folate_Homo sapiens_hsa006700.87560303
51Legionellosis_Homo sapiens_hsa051340.83181759
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82980296
53Pyrimidine metabolism_Homo sapiens_hsa002400.81678301
54Caffeine metabolism_Homo sapiens_hsa002320.81269161
55Retinol metabolism_Homo sapiens_hsa008300.81210202
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80709182
57Non-homologous end-joining_Homo sapiens_hsa034500.73605989
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73268030
59Basal transcription factors_Homo sapiens_hsa030220.71352611
60Ether lipid metabolism_Homo sapiens_hsa005650.71091109
61RNA degradation_Homo sapiens_hsa030180.69307828
62Viral myocarditis_Homo sapiens_hsa054160.68232304
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68177619
64T cell receptor signaling pathway_Homo sapiens_hsa046600.67839233
65Herpes simplex infection_Homo sapiens_hsa051680.67088224
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.67053643
67Nitrogen metabolism_Homo sapiens_hsa009100.65145281
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64344696
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63974496
70Arachidonic acid metabolism_Homo sapiens_hsa005900.63164039
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62909857
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61554416
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.59799816
74Shigellosis_Homo sapiens_hsa051310.59032660
75Cardiac muscle contraction_Homo sapiens_hsa042600.57750231
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57098224
77Leishmaniasis_Homo sapiens_hsa051400.56717214
78Salivary secretion_Homo sapiens_hsa049700.56578999
79Staphylococcus aureus infection_Homo sapiens_hsa051500.56337095
80Metabolic pathways_Homo sapiens_hsa011000.56285701
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50731193
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49342692
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49196968
84Mismatch repair_Homo sapiens_hsa034300.47241305
85Olfactory transduction_Homo sapiens_hsa047400.45289039
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44811716
87Ovarian steroidogenesis_Homo sapiens_hsa049130.44746843
88Chemical carcinogenesis_Homo sapiens_hsa052040.44459727
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40468140
90Pyruvate metabolism_Homo sapiens_hsa006200.40108276
91Fatty acid metabolism_Homo sapiens_hsa012120.39885878
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39226114
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38803668
94Nucleotide excision repair_Homo sapiens_hsa034200.38316396
95Sulfur relay system_Homo sapiens_hsa041220.36419939
96Lysosome_Homo sapiens_hsa041420.35924191
97Fanconi anemia pathway_Homo sapiens_hsa034600.34571069
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34327545
99beta-Alanine metabolism_Homo sapiens_hsa004100.34256744
100Fatty acid degradation_Homo sapiens_hsa000710.33908764

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