GPSM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.45079911
2cell communication by electrical coupling (GO:0010644)4.18703698
3layer formation in cerebral cortex (GO:0021819)4.15029372
4pyrimidine nucleobase catabolic process (GO:0006208)4.14226310
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.08004617
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.04059727
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03074531
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.01358343
9dendritic spine morphogenesis (GO:0060997)4.00601404
10cardiac myofibril assembly (GO:0055003)3.91428994
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.80016653
12protein heterotrimerization (GO:0070208)3.77907394
13regulation of synapse structural plasticity (GO:0051823)3.70524839
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69381020
15synaptic vesicle maturation (GO:0016188)3.62179614
16detection of calcium ion (GO:0005513)3.55009160
17negative regulation of potassium ion transmembrane transport (GO:1901380)3.53536985
18response to pheromone (GO:0019236)3.51088926
19sarcomere organization (GO:0045214)3.50896895
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.49705784
21vocalization behavior (GO:0071625)3.45233619
22regulation of synaptic vesicle exocytosis (GO:2000300)3.39969532
23cerebellar Purkinje cell layer development (GO:0021680)3.39293247
24cell communication involved in cardiac conduction (GO:0086065)3.38480774
25neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.34641868
26regulation of membrane repolarization (GO:0060306)3.33670918
27axonal fasciculation (GO:0007413)3.32137938
28positive regulation of synapse maturation (GO:0090129)3.30487616
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29767524
30central nervous system projection neuron axonogenesis (GO:0021952)3.29628502
31growth hormone secretion (GO:0030252)3.26905520
32neuron recognition (GO:0008038)3.26268528
33dendrite morphogenesis (GO:0048813)3.24472260
34Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.24048203
35protein localization to synapse (GO:0035418)3.23867662
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.23447213
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.22424724
38cell migration in hindbrain (GO:0021535)3.21979528
39neuron cell-cell adhesion (GO:0007158)3.19470747
40cardiac muscle contraction (GO:0060048)3.17547242
41dermatan sulfate metabolic process (GO:0030205)3.14493003
42convergent extension (GO:0060026)3.13455599
43protein retention in ER lumen (GO:0006621)3.13402275
44cochlea morphogenesis (GO:0090103)3.13014751
45cell migration involved in heart development (GO:0060973)3.10696887
46synaptic vesicle exocytosis (GO:0016079)3.08846640
47semaphorin-plexin signaling pathway (GO:0071526)3.08609516
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07900833
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.07055327
50regulation of establishment of planar polarity (GO:0090175)3.06742881
51myofibril assembly (GO:0030239)3.05869651
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04448643
53regulation of synaptic vesicle transport (GO:1902803)3.04041389
54establishment of nucleus localization (GO:0040023)3.02902627
55locomotory exploration behavior (GO:0035641)3.01866312
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01152941
57renal system development (GO:0072001)3.00558963
58camera-type eye morphogenesis (GO:0048593)3.00437999
59cranial nerve morphogenesis (GO:0021602)3.00166781
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98950178
61plasma membrane repair (GO:0001778)2.98760729
62dermatan sulfate biosynthetic process (GO:0030208)2.98223536
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95502498
64cerebellum development (GO:0021549)2.94202901
65regulation of axon extension involved in axon guidance (GO:0048841)2.94192558
66positive regulation of potassium ion transmembrane transport (GO:1901381)2.93020271
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92994204
68postsynaptic membrane organization (GO:0001941)2.92119284
69negative regulation of catenin import into nucleus (GO:0035414)2.91931940
70nucleobase catabolic process (GO:0046113)2.87754873
71auditory behavior (GO:0031223)2.87741106
72regulation of synapse maturation (GO:0090128)2.87467396
73bone trabecula formation (GO:0060346)2.86802234
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85757358
75axon extension involved in axon guidance (GO:0048846)2.84869468
76neuron projection extension involved in neuron projection guidance (GO:1902284)2.84869468
77neuron projection extension (GO:1990138)2.84461903
78regulation of glutamate receptor signaling pathway (GO:1900449)2.83773801
79activation of protein kinase A activity (GO:0034199)2.82696132
80negative regulation of microtubule polymerization (GO:0031115)2.81803546
81neuromuscular process controlling balance (GO:0050885)2.76213175
82maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75571130
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75239703
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.74092900
85membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71954291
86cerebellar granule cell differentiation (GO:0021707)2.70385795
87adult heart development (GO:0007512)2.70069636
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69660643
89mitochondrion transport along microtubule (GO:0047497)2.69660643
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67104237
91sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66627772
92ventricular cardiac muscle cell action potential (GO:0086005)2.65231282
93synaptic vesicle docking involved in exocytosis (GO:0016081)2.64403031
94regulation of axon guidance (GO:1902667)2.63836829
95positive regulation of axon extension (GO:0045773)2.63743173
96glutamate secretion (GO:0014047)2.62638253
97regulation of calcium ion transmembrane transport (GO:1903169)2.62367198
98regulation of calcium ion transmembrane transporter activity (GO:1901019)2.62367198
99collagen fibril organization (GO:0030199)2.59873210
100exploration behavior (GO:0035640)2.58474125
101establishment of mitochondrion localization (GO:0051654)2.57188347
102spinal cord development (GO:0021510)2.56946910
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.56779950
104central nervous system neuron axonogenesis (GO:0021955)2.56005165
105kidney mesenchyme development (GO:0072074)2.55485630
106dendritic spine organization (GO:0097061)2.55302330
107neurotransmitter secretion (GO:0007269)2.54942196
108hippocampus development (GO:0021766)2.53443590
109innervation (GO:0060384)2.52584777
110neuronal ion channel clustering (GO:0045161)2.51826465
111regulation of respiratory system process (GO:0044065)2.50758269
112organelle transport along microtubule (GO:0072384)2.49437236
113regulation of cell communication by electrical coupling (GO:0010649)2.49259727
114DNA damage induced protein phosphorylation (GO:0006975)2.48635453
115cerebellar Purkinje cell differentiation (GO:0021702)2.48571359
116cell-cell junction maintenance (GO:0045217)2.48216976
117regulation of neuronal synaptic plasticity (GO:0048168)2.48022168
118proline transport (GO:0015824)2.46279489
119positive regulation of potassium ion transport (GO:0043268)2.46200119
120negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.45818848
121non-canonical Wnt signaling pathway (GO:0035567)2.45816301
122axon extension (GO:0048675)2.45775145
123membrane repolarization during action potential (GO:0086011)2.45535574
124relaxation of cardiac muscle (GO:0055119)2.45496740
125actomyosin structure organization (GO:0031032)2.45402240
126chondrocyte proliferation (GO:0035988)2.44894569
127regulation of potassium ion transmembrane transport (GO:1901379)2.44012832
128membrane repolarization (GO:0086009)2.43303199
129cardiac muscle cell development (GO:0055013)2.43244593
130adherens junction assembly (GO:0034333)2.42827278
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41942876
132chondroitin sulfate catabolic process (GO:0030207)2.41592728
133sodium ion export (GO:0071436)2.40780088
134positive regulation of synapse assembly (GO:0051965)2.40553005
135response to auditory stimulus (GO:0010996)2.40104033
136potassium ion import (GO:0010107)2.39946255
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.39757703
138striatum development (GO:0021756)2.39689478
139COPI coating of Golgi vesicle (GO:0048205)2.39597517
140protein targeting to plasma membrane (GO:0072661)2.39588259
141positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38552946
142neural tube development (GO:0021915)2.37743828
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.36109744
144developmental cell growth (GO:0048588)2.35062854
145dopamine receptor signaling pathway (GO:0007212)2.34133647
146eye morphogenesis (GO:0048592)2.33453132
147hemidesmosome assembly (GO:0031581)2.33366273
148neurotransmitter-gated ion channel clustering (GO:0072578)2.32175058
149cerebral cortex radially oriented cell migration (GO:0021799)2.32058799
150positive regulation of axonogenesis (GO:0050772)2.30182610
151cellular potassium ion homeostasis (GO:0030007)2.28956267
152cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.28932725
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28260441
154endodermal cell differentiation (GO:0035987)2.26525988
155regulation of axon extension (GO:0030516)2.24720207
156ionotropic glutamate receptor signaling pathway (GO:0035235)2.23859609
157presynaptic membrane organization (GO:0097090)2.23125079
158mating behavior (GO:0007617)2.22548959
159cell adhesion mediated by integrin (GO:0033627)2.21973191
160cell-substrate junction assembly (GO:0007044)2.21889567
161axon ensheathment in central nervous system (GO:0032291)2.21779086
162central nervous system myelination (GO:0022010)2.21779086
163positive regulation of dendrite development (GO:1900006)2.20568794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09185706
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89507869
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88255304
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.87345471
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82313742
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78999387
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.74626694
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.64893221
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62162919
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62162919
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56537902
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.56469982
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.52823083
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51588066
15GBX2_23144817_ChIP-Seq_PC3_Human2.49707799
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48062415
17DROSHA_22980978_ChIP-Seq_HELA_Human2.44877779
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41862607
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32696889
20LXR_22292898_ChIP-Seq_THP-1_Human2.31378820
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.29305527
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29218654
23REST_21632747_ChIP-Seq_MESCs_Mouse2.27963910
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27671800
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26840418
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21603378
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.21266594
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18755186
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.16122602
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12372323
31ZNF274_21170338_ChIP-Seq_K562_Hela2.06182632
32RARB_27405468_Chip-Seq_BRAIN_Mouse2.03306941
33REST_18959480_ChIP-ChIP_MESCs_Mouse2.00048680
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90191375
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.83264987
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76149571
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72358754
38KDM2B_26808549_Chip-Seq_DND41_Human1.72031125
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.64240543
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.63955491
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62315056
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60813743
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.59851550
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59597061
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59533817
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.59211110
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56825563
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.52604913
49RACK7_27058665_Chip-Seq_MCF-7_Human1.49222486
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.48976977
51* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47827551
52AR_21572438_ChIP-Seq_LNCaP_Human1.45319857
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42775563
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42300629
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41134820
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40400861
57KDM2B_26808549_Chip-Seq_K562_Human1.39643498
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38330670
59* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38028156
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.32399406
61TP53_22127205_ChIP-Seq_IMR90_Human1.31899663
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31286607
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30776116
64CREB1_26743006_Chip-Seq_LNCaP_Human1.30238314
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29540196
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25999450
67* TP53_23651856_ChIP-Seq_MEFs_Mouse1.25661791
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24562094
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23248173
70* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23056454
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22787716
72AR_19668381_ChIP-Seq_PC3_Human1.21447238
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20983849
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20800992
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20758701
76* P68_20966046_ChIP-Seq_HELA_Human1.20312328
77VDR_21846776_ChIP-Seq_THP-1_Human1.20143161
78SMC4_20622854_ChIP-Seq_HELA_Human1.20115042
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20083197
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18180303
81IGF1R_20145208_ChIP-Seq_DFB_Human1.18026818
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.17286922
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16979152
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16480214
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16011779
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15399953
87TCF7_22412390_ChIP-Seq_EML_Mouse1.14797404
88SMAD4_21799915_ChIP-Seq_A2780_Human1.14441657
89* ESR2_21235772_ChIP-Seq_MCF-7_Human1.14224669
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12986004
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11404114
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.11075482
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10472859
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10355395
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10242574
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.08763108
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08641189
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08571602
99SOX3_22085726_ChIP-Seq_NPCs_Mouse1.06179080
100SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05462794
101CTCF_27219007_Chip-Seq_Bcells_Human1.05103883
102RNF2_27304074_Chip-Seq_NSC_Mouse1.04797723
103* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04693126
104SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04370058
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.00535065
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00475678
107SMAD4_21741376_ChIP-Seq_HESCs_Human1.00393647
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00391364
109CLOCK_20551151_ChIP-Seq_293T_Human0.99795745
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99401754
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99339543
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98002365
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97394149
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95741316
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95299023
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95279612
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.94560420
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93977125
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92974596
120STAT3_23295773_ChIP-Seq_U87_Human0.92683694
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92381857
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.92350330
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92102566
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91662160
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91411738
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.91099084
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90912470
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.90855287
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.90289254
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90164176
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90069855
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87851554
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87243102
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87243102
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86366528
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86042655
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85048643
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84711490
139AHR_22903824_ChIP-Seq_MCF-7_Human0.84651415
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84584386
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83872127
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82765093
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81689320
144AR_25329375_ChIP-Seq_VCAP_Human0.81361681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.99867495
2MP0002837_dystrophic_cardiac_calcinosis3.84195879
3MP0003705_abnormal_hypodermis_morpholog3.48594409
4MP0004859_abnormal_synaptic_plasticity3.00198865
5MP0000751_myopathy2.91700823
6MP0005503_abnormal_tendon_morphology2.75039400
7MP0009780_abnormal_chondrocyte_physiolo2.69254535
8MP0005423_abnormal_somatic_nervous2.60264971
9MP0004215_abnormal_myocardial_fiber2.49056781
10MP0001958_emphysema2.43240332
11MP0004084_abnormal_cardiac_muscle2.39332085
12MP0003279_aneurysm2.35491982
13MP0003635_abnormal_synaptic_transmissio2.32365038
14MP0004270_analgesia2.31877695
15MP0005257_abnormal_intraocular_pressure2.30406762
16MP0010030_abnormal_orbit_morphology2.30398371
17MP0002909_abnormal_adrenal_gland2.27008884
18MP0002249_abnormal_larynx_morphology2.20735642
19MP0004272_abnormal_basement_membrane2.18868813
20MP0003283_abnormal_digestive_organ2.14172203
21MP0000778_abnormal_nervous_system2.14130396
22MP0005623_abnormal_meninges_morphology2.10832397
23MP0003137_abnormal_impulse_conducting2.09500307
24MP0003122_maternal_imprinting2.01672082
25MP0009384_cardiac_valve_regurgitation1.98469781
26MP0003880_abnormal_central_pattern1.94876098
27MP0003646_muscle_fatigue1.91374579
28MP0002063_abnormal_learning/memory/cond1.90677438
29MP0000013_abnormal_adipose_tissue1.87985825
30MP0005275_abnormal_skin_tensile1.80974327
31MP0002184_abnormal_innervation1.76770838
32MP0006072_abnormal_retinal_apoptosis1.75470144
33MP0004085_abnormal_heartbeat1.72136592
34MP0000534_abnormal_ureter_morphology1.70976088
35MP0000566_synostosis1.70718128
36MP0004036_abnormal_muscle_relaxation1.65149003
37MP0002234_abnormal_pharynx_morphology1.60643718
38MP0004145_abnormal_muscle_electrophysio1.58753681
39MP0002572_abnormal_emotion/affect_behav1.55831508
40MP0002734_abnormal_mechanical_nocicepti1.52563799
41MP0009745_abnormal_behavioral_response1.52173312
42MP0003942_abnormal_urinary_system1.51990920
43MP0005508_abnormal_skeleton_morphology1.51042947
44MP0002972_abnormal_cardiac_muscle1.49648831
45MP0005409_darkened_coat_color1.47890854
46MP0005394_taste/olfaction_phenotype1.45021934
47MP0005499_abnormal_olfactory_system1.45021934
48MP0002064_seizures1.44690212
49MP0005645_abnormal_hypothalamus_physiol1.44564573
50MP0001348_abnormal_lacrimal_gland1.44137540
51MP0005330_cardiomyopathy1.43550934
52MP0002557_abnormal_social/conspecific_i1.41519650
53MP0005646_abnormal_pituitary_gland1.40448449
54MP0000955_abnormal_spinal_cord1.39363805
55MP0009250_abnormal_appendicular_skeleto1.39244334
56MP0004924_abnormal_behavior1.38327820
57MP0005386_behavior/neurological_phenoty1.38327820
58MP0004811_abnormal_neuron_physiology1.37892459
59MP0003329_amyloid_beta_deposits1.37138443
60MP0009053_abnormal_anal_canal1.35884093
61MP0001486_abnormal_startle_reflex1.35013379
62MP0001849_ear_inflammation1.34211539
63MP0000428_abnormal_craniofacial_morphol1.32770461
64MP0002272_abnormal_nervous_system1.31683295
65MP0004233_abnormal_muscle_weight1.30324073
66MP0008569_lethality_at_weaning1.29967503
67MP0009379_abnormal_foot_pigmentation1.28805397
68MP0005620_abnormal_muscle_contractility1.27700510
69MP0008961_abnormal_basal_metabolism1.27391456
70MP0010368_abnormal_lymphatic_system1.25870727
71MP0002638_abnormal_pupillary_reflex1.25101879
72MP0002733_abnormal_thermal_nociception1.24777316
73MP0010386_abnormal_urinary_bladder1.24227432
74MP0000749_muscle_degeneration1.22453820
75MP0002067_abnormal_sensory_capabilities1.22307677
76MP0005187_abnormal_penis_morphology1.21132873
77MP0003119_abnormal_digestive_system1.20854469
78MP0002882_abnormal_neuron_morphology1.19445002
79MP0008789_abnormal_olfactory_epithelium1.19334670
80MP0004858_abnormal_nervous_system1.19006003
81MP0000631_abnormal_neuroendocrine_gland1.18789035
82MP0001440_abnormal_grooming_behavior1.16948085
83MP0002116_abnormal_craniofacial_bone1.16398118
84MP0009046_muscle_twitch1.16219792
85MP0002932_abnormal_joint_morphology1.14389303
86MP0000462_abnormal_digestive_system1.14169129
87MP0003634_abnormal_glial_cell1.13291279
88MP0004087_abnormal_muscle_fiber1.13231546
89MP0004043_abnormal_pH_regulation1.12574920
90MP0003787_abnormal_imprinting1.12317871
91MP0001502_abnormal_circadian_rhythm1.10463404
92MP0001970_abnormal_pain_threshold1.09950843
93MP0002822_catalepsy1.09908232
94MP0002735_abnormal_chemical_nociception1.09466125
95MP0000579_abnormal_nail_morphology1.09252019
96* MP0006276_abnormal_autonomic_nervous1.08471749
97MP0005551_abnormal_eye_electrophysiolog1.07147385
98MP0002152_abnormal_brain_morphology1.04475964
99MP0001968_abnormal_touch/_nociception1.04363635
100MP0002106_abnormal_muscle_physiology1.04287241
101MP0004484_altered_response_of1.03183256
102MP0003091_abnormal_cell_migration1.01868396
103MP0000537_abnormal_urethra_morphology1.01635733
104MP0002108_abnormal_muscle_morphology1.00727490
105MP0000049_abnormal_middle_ear0.99945099
106MP0000733_abnormal_muscle_development0.99798658
107MP0005253_abnormal_eye_physiology0.98051774
108MP0002066_abnormal_motor_capabilities/c0.96849122
109MP0000759_abnormal_skeletal_muscle0.96774827
110MP0005171_absent_coat_pigmentation0.96713973
111MP0002653_abnormal_ependyma_morphology0.96439764
112MP0000767_abnormal_smooth_muscle0.96402746
113MP0003121_genomic_imprinting0.95378292
114MP0004885_abnormal_endolymph0.95091626
115MP0003115_abnormal_respiratory_system0.94084226
116MP0002114_abnormal_axial_skeleton0.94009559
117MP0005369_muscle_phenotype0.93940155
118MP0000003_abnormal_adipose_tissue0.93830638
119MP0003861_abnormal_nervous_system0.93819178
120MP0000750_abnormal_muscle_regeneration0.93709032
121MP0001529_abnormal_vocalization0.93693824
122MP0003890_abnormal_embryonic-extraembry0.93292997
123MP0003755_abnormal_palate_morphology0.92979940
124MP0001299_abnormal_eye_distance/0.92901263
125MP0003566_abnormal_cell_adhesion0.92407129
126MP0006138_congestive_heart_failure0.92298606
127MP0003123_paternal_imprinting0.92136482
128MP0004133_heterotaxia0.91290997
129MP0003385_abnormal_body_wall0.90778887
130MP0000762_abnormal_tongue_morphology0.90674061
131MP0002896_abnormal_bone_mineralization0.90662197
132MP0005385_cardiovascular_system_phenoty0.90551629
133MP0001544_abnormal_cardiovascular_syste0.90551629
134MP0000678_abnormal_parathyroid_gland0.89705751
135MP0008775_abnormal_heart_ventricle0.89677512
136MP0001944_abnormal_pancreas_morphology0.89044924
137MP0010630_abnormal_cardiac_muscle0.85890943
138MP0000569_abnormal_digit_pigmentation0.85506875
139MP0002081_perinatal_lethality0.85229254
140MP0002089_abnormal_postnatal_growth/wei0.85092182
141MP0000432_abnormal_head_morphology0.84802744
142MP0002269_muscular_atrophy0.83544827
143MP0001984_abnormal_olfaction0.83225419
144MP0002751_abnormal_autonomic_nervous0.83094496
145MP0002693_abnormal_pancreas_physiology0.82973095
146* MP0005595_abnormal_vascular_smooth0.82682765
147MP0009278_abnormal_bone_marrow0.82658931
148MP0006292_abnormal_olfactory_placode0.82437144
149MP0003935_abnormal_craniofacial_develop0.81255982
150MP0000681_abnormal_thyroid_gland0.79494414
151MP0002697_abnormal_eye_size0.77481780
152MP0002092_abnormal_eye_morphology0.74654308
153MP0001177_atelectasis0.73952379
154MP0002233_abnormal_nose_morphology0.72857818
155MP0000163_abnormal_cartilage_morphology0.72500366
156MP0001943_abnormal_respiration0.72087154
157MP0001188_hyperpigmentation0.71765691

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.70229168
2Protrusio acetabuli (HP:0003179)4.59458874
3Sudden death (HP:0001699)4.06821089
4Shallow orbits (HP:0000586)3.64576275
5Prolonged QT interval (HP:0001657)3.59068068
6Atrophic scars (HP:0001075)3.48676367
7Bladder diverticulum (HP:0000015)3.44460877
8Atrial fibrillation (HP:0005110)3.40040390
9Fragile skin (HP:0001030)3.30046795
10Primary atrial arrhythmia (HP:0001692)3.29383280
11Obstructive sleep apnea (HP:0002870)3.26426958
12Pheochromocytoma (HP:0002666)3.25418274
13Visual hallucinations (HP:0002367)3.25066775
14Supraventricular tachycardia (HP:0004755)3.14432496
15Supraventricular arrhythmia (HP:0005115)3.08917237
16Bundle branch block (HP:0011710)3.01908762
17Neonatal short-limb short stature (HP:0008921)2.96597968
18Broad metatarsal (HP:0001783)2.90966558
19Ankle contracture (HP:0006466)2.88962663
20Syncope (HP:0001279)2.86655694
21Ventricular fibrillation (HP:0001663)2.85912925
22Turricephaly (HP:0000262)2.83477024
23Ventricular tachycardia (HP:0004756)2.82412708
24Abnormality of the aortic arch (HP:0012303)2.81780272
25Ulnar bowing (HP:0003031)2.80961668
26Abnormal EKG (HP:0003115)2.72770397
27Abnormality of dentin (HP:0010299)2.70567463
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69851117
29Neuroendocrine neoplasm (HP:0100634)2.69308205
30Mitral regurgitation (HP:0001653)2.68441956
31Spinal rigidity (HP:0003306)2.64994221
32Abnormality of the calf musculature (HP:0001430)2.62286600
33Genu recurvatum (HP:0002816)2.60414946
34Calf muscle hypertrophy (HP:0008981)2.55558602
35Hyperinsulinemic hypoglycemia (HP:0000825)2.52749499
36Soft skin (HP:0000977)2.51769185
37Cerebral aneurysm (HP:0004944)2.50726209
38Subaortic stenosis (HP:0001682)2.49830618
39Abnormality of the left ventricular outflow tract (HP:0011103)2.49830618
40Poor eye contact (HP:0000817)2.47253785
41Central scotoma (HP:0000603)2.43411290
42Cervical subluxation (HP:0003308)2.43238837
43Aortic dissection (HP:0002647)2.41458580
44Exercise-induced myalgia (HP:0003738)2.41359705
45Ankle clonus (HP:0011448)2.37163095
46Vascular tortuosity (HP:0004948)2.36455532
47Hamartoma of the eye (HP:0010568)2.35979413
48Amyotrophic lateral sclerosis (HP:0007354)2.35816051
49Wormian bones (HP:0002645)2.35067469
50Aortic aneurysm (HP:0004942)2.29152831
51Focal seizures (HP:0007359)2.28571899
52Limb dystonia (HP:0002451)2.26527659
53Focal motor seizures (HP:0011153)2.24844302
54Biconcave vertebral bodies (HP:0004586)2.23553507
55Large for gestational age (HP:0001520)2.22244110
56Hypoglycemic seizures (HP:0002173)2.21795299
57Type 1 muscle fiber predominance (HP:0003803)2.21620051
58Muscle hypertrophy of the lower extremities (HP:0008968)2.21358357
59Epileptic encephalopathy (HP:0200134)2.20973591
60Insomnia (HP:0100785)2.20946091
61EEG with generalized epileptiform discharges (HP:0011198)2.20214964
62Wide anterior fontanel (HP:0000260)2.20157344
63Coronal craniosynostosis (HP:0004440)2.19237063
64Upper limb amyotrophy (HP:0009129)2.19175164
65Distal upper limb amyotrophy (HP:0007149)2.19175164
66Hypsarrhythmia (HP:0002521)2.19005744
67Annular pancreas (HP:0001734)2.18725278
68Depression (HP:0000716)2.18645104
69Neoplasm of the adrenal gland (HP:0100631)2.18611675
70Agitation (HP:0000713)2.17278354
71Disproportionate tall stature (HP:0001519)2.16925901
72Hyperextensible skin (HP:0000974)2.16872864
73Neoplasm of the heart (HP:0100544)2.16713961
74Myokymia (HP:0002411)2.16661806
75Joint laxity (HP:0001388)2.15751884
76Failure to thrive in infancy (HP:0001531)2.15440197
77Supranuclear gaze palsy (HP:0000605)2.13984934
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12287198
79Hypoplasia of the brainstem (HP:0002365)2.12287198
80Ventricular arrhythmia (HP:0004308)2.10695862
81Mildly elevated creatine phosphokinase (HP:0008180)2.10090141
82Macroorchidism (HP:0000053)2.10027048
83Blue sclerae (HP:0000592)2.09183694
84Abnormal pancreas size (HP:0012094)2.09115384
85Arterial tortuosity (HP:0005116)2.08964808
86Renovascular hypertension (HP:0100817)2.08738007
87Epileptiform EEG discharges (HP:0011182)2.08545407
88Renal duplication (HP:0000075)2.08190391
89Broad face (HP:0000283)2.05954069
90Thin ribs (HP:0000883)2.04677917
91Achilles tendon contracture (HP:0001771)2.03861501
92Deviation of the hallux (HP:0010051)2.03515813
93Hyperacusis (HP:0010780)2.03372872
94Mitral valve prolapse (HP:0001634)2.03370122
95Abnormal social behavior (HP:0012433)2.03060733
96Impaired social interactions (HP:0000735)2.03060733
97Heart block (HP:0012722)2.02195011
98Hallux valgus (HP:0001822)2.01285347
99Aplasia involving bones of the upper limbs (HP:0009823)2.00067776
100Aplasia of the phalanges of the hand (HP:0009802)2.00067776
101Aplasia involving bones of the extremities (HP:0009825)2.00067776
102Lipoatrophy (HP:0100578)1.99257928
103Follicular hyperkeratosis (HP:0007502)1.99170971
104Hepatoblastoma (HP:0002884)1.98037475
105Long toe (HP:0010511)1.97666441
106Megalocornea (HP:0000485)1.97536132
107Ketoacidosis (HP:0001993)1.96859573
108Left ventricular hypertrophy (HP:0001712)1.96468715
109Truncal ataxia (HP:0002078)1.96100085
110Broad-based gait (HP:0002136)1.95820269
111Athetosis (HP:0002305)1.94327379
112Megalencephaly (HP:0001355)1.93135639
113Abnormality of the metopic suture (HP:0005556)1.93005786
114Elfin facies (HP:0004428)1.92743171
115Short 4th metacarpal (HP:0010044)1.92538090
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92538090
117Lymphangioma (HP:0100764)1.92120182
118Neoplasm of the peripheral nervous system (HP:0100007)1.90799021
119Lissencephaly (HP:0001339)1.89453476
120Myotonia (HP:0002486)1.89055057
121Bronchomalacia (HP:0002780)1.87887769
122Insulin-resistant diabetes mellitus (HP:0000831)1.87605423
123Lower limb amyotrophy (HP:0007210)1.87468896
124Shawl scrotum (HP:0000049)1.86041898
125Aortic regurgitation (HP:0001659)1.85107347
126Partial duplication of the phalanx of hand (HP:0009999)1.85077576
127Hand muscle atrophy (HP:0009130)1.84804410
128Buphthalmos (HP:0000557)1.84595280
129Congenital glaucoma (HP:0001087)1.84542556
130Prominent metopic ridge (HP:0005487)1.84288666
131Natal tooth (HP:0000695)1.84269133
132Spinal canal stenosis (HP:0003416)1.84243620
133Abnormal atrioventricular conduction (HP:0005150)1.83990418
134Camptodactyly of toe (HP:0001836)1.83960532
135Broad long bones (HP:0005622)1.83880654
136Arnold-Chiari malformation (HP:0002308)1.83852682
137Torticollis (HP:0000473)1.83803771
138Bowed forearm bones (HP:0003956)1.83112852
139Bowing of the arm (HP:0006488)1.83112852
140Exotropia (HP:0000577)1.81818695
141Abnormality of the 4th metacarpal (HP:0010012)1.81676785
142Symptomatic seizures (HP:0011145)1.80980352
143Progressive cerebellar ataxia (HP:0002073)1.80756646
144Anxiety (HP:0000739)1.79633101
145Drooling (HP:0002307)1.78788950
146Excessive salivation (HP:0003781)1.78788950
147Atrioventricular block (HP:0001678)1.78541077
148Patellar dislocation (HP:0002999)1.76808975
149Partial duplication of thumb phalanx (HP:0009944)1.76323349
150Stridor (HP:0010307)1.75310132
151Dilated cardiomyopathy (HP:0001644)1.75242915
152Abnormality of the lower motor neuron (HP:0002366)1.75022113
153Palpitations (HP:0001962)1.74942211
154Back pain (HP:0003418)1.74504150
155Aneurysm (HP:0002617)1.74413685
156Amblyopia (HP:0000646)1.74216867
157Limb-girdle muscle atrophy (HP:0003797)1.73824119
158Premature skin wrinkling (HP:0100678)1.73758108
159Wrist flexion contracture (HP:0001239)1.73609335
160Muscle fiber splitting (HP:0003555)1.73397059
161Mild short stature (HP:0003502)1.72984470
162Difficulty climbing stairs (HP:0003551)1.72612635
163Action tremor (HP:0002345)1.71876003
164Pancreatic islet-cell hyperplasia (HP:0004510)1.71531179
165Hypoventilation (HP:0002791)1.71354405
166Flat cornea (HP:0007720)1.71154509
167Broad distal phalanx of finger (HP:0009836)1.69998348
168Dilatation of the ascending aorta (HP:0005111)1.69446132
169Slender build (HP:0001533)1.69019800
170Short nail (HP:0001799)1.67916248
171Abnormality of the Achilles tendon (HP:0005109)1.66551365
172Abnormality of the phalanges of the hallux (HP:0010057)1.65976047
173Papillary thyroid carcinoma (HP:0002895)1.65965258
174Pointed chin (HP:0000307)1.65446051
175Pachygyria (HP:0001302)1.65422723
176Broad finger (HP:0001500)1.65289155
177Overriding aorta (HP:0002623)1.65272934
178Broad phalanx (HP:0006009)1.64966104
179Atelectasis (HP:0100750)1.64960679
180Abnormality of the parathyroid morphology (HP:0011766)1.62288352
181Overgrowth (HP:0001548)1.59872999
182Bowel diverticulosis (HP:0005222)1.59800661
183Scotoma (HP:0000575)1.59370567
184Sacral dimple (HP:0000960)1.59329731
185Increased variability in muscle fiber diameter (HP:0003557)1.56372318
186Impaired smooth pursuit (HP:0007772)1.55783133
187Bradycardia (HP:0001662)1.55007923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.33785128
2TAOK23.43706979
3INSRR2.77987914
4PHKG12.63822782
5PHKG22.63822782
6MAP3K42.42537329
7EEF2K2.36392185
8NTRK32.33339961
9UHMK12.03865911
10SIK12.02605108
11NTRK22.00887720
12PAK61.97471030
13PRKD31.94800959
14MINK11.92243390
15MAPK131.89526484
16PAK31.85713259
17DDR21.80148001
18ERBB31.79468053
19PASK1.71823859
20SIK21.70197839
21KSR11.69358643
22PDGFRA1.65358493
23TTN1.63657785
24MAP2K71.61652886
25TRIB31.56295839
26DYRK21.55479871
27EPHB21.43272089
28RIPK11.40069408
29MAP2K61.37682588
30MAP3K91.37089753
31CDC42BPA1.36367291
32LMTK21.34235480
33NTRK11.32285046
34HIPK21.28920752
35PRKD21.24712289
36CDK51.22464337
37PAK21.21987458
38PKN21.20673246
39MTOR1.18970298
40SMG11.16088107
41MARK21.14391533
42PRPF4B1.12605150
43DMPK1.10508183
44DYRK1A1.08218621
45MUSK1.07686662
46MAP3K61.03549111
47RPS6KA21.03143031
48MAP3K101.02779064
49CAMK1D1.00265250
50CAMKK10.99820477
51SGK2230.98084677
52SGK4940.98084677
53DAPK20.96562720
54LATS20.95361529
55MAP2K40.93599328
56EPHA30.92618152
57TYRO30.91234604
58MYLK0.91164155
59CCNB10.88781558
60FGFR20.88035734
61RET0.87308799
62SGK20.85761130
63TAOK10.85116221
64ARAF0.83597736
65WNK40.81578459
66DYRK1B0.80793589
67ROCK10.80735811
68PRKCH0.79417408
69TESK10.78886362
70RPS6KC10.77546399
71RPS6KL10.77546399
72LIMK10.75861549
73AKT30.75825655
74CAMK40.75182544
75CAMK2D0.74688530
76PRKCE0.74627470
77CDK180.74453080
78PINK10.74418878
79PKN10.73536226
80WNK30.72848396
81PDGFRB0.72706809
82DAPK30.72309816
83WNK10.71488318
84CAMKK20.71324721
85CDK150.71197614
86CDK140.68040153
87BRAF0.67927214
88EPHA40.67552015
89STK380.66643117
90PRKD10.65426159
91PRKAA10.64797836
92MAPK90.64461247
93CASK0.64001719
94PRKCG0.63981932
95CAMK2B0.63587460
96MAP3K110.63367823
97CAMK2G0.63213804
98CDK11A0.62956988
99CAMK2A0.62550238
100EPHB10.61878673
101PIM20.61382522
102KSR20.61056534
103SGK30.60492884
104STK110.59922970
105RPS6KA60.59632257
106MET0.59596021
107CAMK1G0.58286558
108ABL20.55897928
109ERN10.54857554
110TNIK0.54522955
111CAMK10.52519817
112LATS10.51834162
113CDK120.51721701
114ICK0.51644725
115MAP3K70.51601363
116MOS0.51424531
117ADRBK10.51203092
118SGK10.50376457
119BCR0.49249698
120ILK0.49182369
121IRAK30.48879761
122ROCK20.48859025
123PRKCZ0.48605282
124FGFR10.48228145
125BMX0.47762348
126ALK0.46719221
127NEK60.46655559
128CSNK1G20.45300978
129MAP3K20.44510582
130MAPK150.43917639
131GRK50.43443630
132OBSCN0.42943893
133MAPK120.42941973
134MAP3K50.42397538
135MAPK100.41860195
136NEK10.40180304
137FER0.40177566
138PTK20.40033005
139BMPR1B0.39497732
140PLK20.39173935

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049112.39943934
2Circadian entrainment_Homo sapiens_hsa047132.20552513
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.20119800
4ECM-receptor interaction_Homo sapiens_hsa045122.13150883
5Dilated cardiomyopathy_Homo sapiens_hsa054142.11420701
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.10343732
7Cardiac muscle contraction_Homo sapiens_hsa042602.09759976
8GABAergic synapse_Homo sapiens_hsa047272.06680014
9Nicotine addiction_Homo sapiens_hsa050332.03760108
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.00370062
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99814251
12Synaptic vesicle cycle_Homo sapiens_hsa047211.92023071
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91039841
14Morphine addiction_Homo sapiens_hsa050321.88441726
15Dopaminergic synapse_Homo sapiens_hsa047281.86541258
16Type II diabetes mellitus_Homo sapiens_hsa049301.83440956
17Glutamatergic synapse_Homo sapiens_hsa047241.78983674
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77560254
19Cholinergic synapse_Homo sapiens_hsa047251.76459329
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70644375
21Long-term potentiation_Homo sapiens_hsa047201.69648711
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67181435
23Taste transduction_Homo sapiens_hsa047421.64502802
24Olfactory transduction_Homo sapiens_hsa047401.62684730
25Amphetamine addiction_Homo sapiens_hsa050311.62089499
26* Cocaine addiction_Homo sapiens_hsa050301.58896485
27Axon guidance_Homo sapiens_hsa043601.57693330
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51067434
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49998167
30Gap junction_Homo sapiens_hsa045401.38833610
31Oxytocin signaling pathway_Homo sapiens_hsa049211.35625672
32Serotonergic synapse_Homo sapiens_hsa047261.35170908
33Renin secretion_Homo sapiens_hsa049241.34271616
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31800490
35Chronic myeloid leukemia_Homo sapiens_hsa052201.24849576
36Phototransduction_Homo sapiens_hsa047441.23275176
37Prion diseases_Homo sapiens_hsa050201.22784265
38Estrogen signaling pathway_Homo sapiens_hsa049151.19621165
39Gastric acid secretion_Homo sapiens_hsa049711.17442779
40cAMP signaling pathway_Homo sapiens_hsa040241.14209679
41Long-term depression_Homo sapiens_hsa047301.14102340
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14071864
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.13215649
44Bladder cancer_Homo sapiens_hsa052191.09946420
45Salivary secretion_Homo sapiens_hsa049701.09267685
46Protein digestion and absorption_Homo sapiens_hsa049741.09056137
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07226634
48Parkinsons disease_Homo sapiens_hsa050121.06310942
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06182182
50GnRH signaling pathway_Homo sapiens_hsa049121.03670520
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03513496
52MicroRNAs in cancer_Homo sapiens_hsa052061.03343566
53Calcium signaling pathway_Homo sapiens_hsa040201.03270903
54Proteoglycans in cancer_Homo sapiens_hsa052051.01030740
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00852834
56Endometrial cancer_Homo sapiens_hsa052131.00187158
57Glioma_Homo sapiens_hsa052140.98707399
58Alzheimers disease_Homo sapiens_hsa050100.95984267
59Melanogenesis_Homo sapiens_hsa049160.92803767
60ErbB signaling pathway_Homo sapiens_hsa040120.92461754
61Melanoma_Homo sapiens_hsa052180.91287336
62Circadian rhythm_Homo sapiens_hsa047100.91226443
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89886133
64Amoebiasis_Homo sapiens_hsa051460.88493422
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.86603983
66Renal cell carcinoma_Homo sapiens_hsa052110.86091651
67Glucagon signaling pathway_Homo sapiens_hsa049220.85540483
68Vibrio cholerae infection_Homo sapiens_hsa051100.84449553
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83802196
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83143603
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82567929
72Insulin signaling pathway_Homo sapiens_hsa049100.82374049
73Pathways in cancer_Homo sapiens_hsa052000.81818361
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81562072
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81380589
76Hedgehog signaling pathway_Homo sapiens_hsa043400.81225594
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81083500
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80397298
79Colorectal cancer_Homo sapiens_hsa052100.79542335
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79486044
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.79465857
82Small cell lung cancer_Homo sapiens_hsa052220.79279565
83Alcoholism_Homo sapiens_hsa050340.78972635
84Viral myocarditis_Homo sapiens_hsa054160.78404638
85Wnt signaling pathway_Homo sapiens_hsa043100.77321832
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76893495
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76187056
88mTOR signaling pathway_Homo sapiens_hsa041500.75043773
89Pancreatic secretion_Homo sapiens_hsa049720.70693194
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69607114
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69004831
92Oxidative phosphorylation_Homo sapiens_hsa001900.68907086
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67788248
94MAPK signaling pathway_Homo sapiens_hsa040100.67430422
95Pancreatic cancer_Homo sapiens_hsa052120.67107874
96Adherens junction_Homo sapiens_hsa045200.67065050
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.66170843
98Notch signaling pathway_Homo sapiens_hsa043300.65682925
99Insulin resistance_Homo sapiens_hsa049310.65438200
100N-Glycan biosynthesis_Homo sapiens_hsa005100.65387413
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.61447871
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.60858200
103AMPK signaling pathway_Homo sapiens_hsa041520.60803373
104Endocytosis_Homo sapiens_hsa041440.60028563
105Basal cell carcinoma_Homo sapiens_hsa052170.59464459
106Huntingtons disease_Homo sapiens_hsa050160.58728268
107Oocyte meiosis_Homo sapiens_hsa041140.58550613
108Hippo signaling pathway_Homo sapiens_hsa043900.58166326
109Sulfur relay system_Homo sapiens_hsa041220.57842830
110Butanoate metabolism_Homo sapiens_hsa006500.57432737
111Prostate cancer_Homo sapiens_hsa052150.57349521
112Focal adhesion_Homo sapiens_hsa045100.57072744
113VEGF signaling pathway_Homo sapiens_hsa043700.56903093
114Ras signaling pathway_Homo sapiens_hsa040140.55834849
115Inositol phosphate metabolism_Homo sapiens_hsa005620.55607700
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55505892
117Prolactin signaling pathway_Homo sapiens_hsa049170.55177529
118Choline metabolism in cancer_Homo sapiens_hsa052310.54000048
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53701557
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53505927
121Thyroid hormone synthesis_Homo sapiens_hsa049180.53034379
122Rap1 signaling pathway_Homo sapiens_hsa040150.52444574
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51856607
124Non-small cell lung cancer_Homo sapiens_hsa052230.48833494
125Tight junction_Homo sapiens_hsa045300.48461571
126Dorso-ventral axis formation_Homo sapiens_hsa043200.47810795
127Lysine degradation_Homo sapiens_hsa003100.46764967

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