GPSM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.87261095
2leukocyte aggregation (GO:0070486)5.52027632
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.48167696
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.48167696
5antigen processing and presentation of endogenous antigen (GO:0019883)5.18418176
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.07462455
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99300520
8regulation of B cell receptor signaling pathway (GO:0050855)4.92996407
9negative regulation of cell killing (GO:0031342)4.82737859
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.82737859
11detection of other organism (GO:0098543)4.78530759
12detection of bacterium (GO:0016045)4.74326162
13regulation of gamma-delta T cell differentiation (GO:0045586)4.53951073
14regulation of gamma-delta T cell activation (GO:0046643)4.31055307
15negative T cell selection (GO:0043383)4.27528600
16negative thymic T cell selection (GO:0045060)4.25688173
17positive thymic T cell selection (GO:0045059)4.13373965
18negative regulation of lymphocyte mediated immunity (GO:0002707)4.07512299
19neutrophil activation involved in immune response (GO:0002283)4.04027739
20T cell migration (GO:0072678)4.01928196
21immunoglobulin mediated immune response (GO:0016064)3.97571194
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90478052
23positive regulation by symbiont of host defense response (GO:0052509)3.88631478
24modulation by symbiont of host defense response (GO:0052031)3.88631478
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88631478
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88631478
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.88631478
28modulation by symbiont of host immune response (GO:0052553)3.88631478
29regulation of B cell differentiation (GO:0045577)3.86533262
30detection of external biotic stimulus (GO:0098581)3.85302097
31respiratory burst (GO:0045730)3.81723310
32response to interleukin-15 (GO:0070672)3.79548509
33interferon-gamma production (GO:0032609)3.71225190
34positive regulation of B cell differentiation (GO:0045579)3.69699245
35B cell receptor signaling pathway (GO:0050853)3.68470329
36negative regulation of leukocyte mediated immunity (GO:0002704)3.68355940
37thymic T cell selection (GO:0045061)3.64897382
38regulation of mast cell degranulation (GO:0043304)3.62477907
39cellular response to interleukin-15 (GO:0071350)3.62286044
40cellular extravasation (GO:0045123)3.60886186
41negative regulation of T cell mediated immunity (GO:0002710)3.56720947
42negative regulation of phagocytosis (GO:0050765)3.55672294
43response to peptidoglycan (GO:0032494)3.54857078
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54307650
45leukocyte migration involved in inflammatory response (GO:0002523)3.52495160
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47809915
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.47769343
48T cell selection (GO:0045058)3.46545781
49neutrophil activation (GO:0042119)3.44895757
50tolerance induction (GO:0002507)3.43771071
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43042783
52regulation of tolerance induction (GO:0002643)3.42428596
53mast cell activation (GO:0045576)3.42357568
54positive T cell selection (GO:0043368)3.40960247
55detection of biotic stimulus (GO:0009595)3.36976740
56negative regulation of erythrocyte differentiation (GO:0045647)3.36341696
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35960929
58regulation of interferon-beta biosynthetic process (GO:0045357)3.35322141
59antigen processing and presentation via MHC class Ib (GO:0002475)3.34525554
60regulation of mast cell activation involved in immune response (GO:0033006)3.31669141
61leukocyte cell-cell adhesion (GO:0007159)3.31154692
62regulation of natural killer cell mediated immunity (GO:0002715)3.29756678
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.29756678
64granulocyte activation (GO:0036230)3.29338481
65response to type I interferon (GO:0034340)3.29096740
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27674519
67regulation of interleukin-12 biosynthetic process (GO:0045075)3.27351502
68detection of molecule of bacterial origin (GO:0032490)3.26456901
69response to host (GO:0075136)3.26182898
70response to host defenses (GO:0052200)3.26182898
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26182898
72type I interferon signaling pathway (GO:0060337)3.25330971
73cellular response to type I interferon (GO:0071357)3.25330971
74B cell mediated immunity (GO:0019724)3.24987109
75regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24707240
76microglial cell activation (GO:0001774)3.24082617
77germinal center formation (GO:0002467)3.23659726
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22953166
79positive regulation of antigen processing and presentation (GO:0002579)3.22109377
80antigen receptor-mediated signaling pathway (GO:0050851)3.21314209
81myeloid dendritic cell activation (GO:0001773)3.18271331
82regulation of T cell mediated cytotoxicity (GO:0001914)3.16726679
83interferon-gamma-mediated signaling pathway (GO:0060333)3.14578510
84regulation of leukocyte degranulation (GO:0043300)3.13258064
85T cell costimulation (GO:0031295)3.13104931
86positive regulation of interferon-alpha production (GO:0032727)3.12498022
87defense response to protozoan (GO:0042832)3.11657366
88regulation of mast cell activation (GO:0033003)3.11247845
89negative regulation of interleukin-12 production (GO:0032695)3.11220859
90T cell receptor signaling pathway (GO:0050852)3.10657244
91sequestering of actin monomers (GO:0042989)3.10596546
92lymphocyte costimulation (GO:0031294)3.08445539
93cellular response to zinc ion (GO:0071294)3.07669019
94response to protozoan (GO:0001562)3.07198933
95positive regulation of T cell mediated cytotoxicity (GO:0001916)3.06791107
96neutrophil mediated immunity (GO:0002446)3.05073756
97macrophage activation (GO:0042116)3.04970530
98production of molecular mediator involved in inflammatory response (GO:0002532)3.04239175
99myeloid cell activation involved in immune response (GO:0002275)3.03927089
100regulation of T cell receptor signaling pathway (GO:0050856)3.03849540
101negative regulation of innate immune response (GO:0045824)3.02574867
102regulation of alpha-beta T cell proliferation (GO:0046640)3.02154874
103NIK/NF-kappaB signaling (GO:0038061)3.02132464
104regulation of interferon-alpha production (GO:0032647)3.00482285
105myeloid dendritic cell differentiation (GO:0043011)3.00474778
106regulation of regulatory T cell differentiation (GO:0045589)2.99829247
107regulation of T cell tolerance induction (GO:0002664)2.95985321
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95911291
109negative regulation of T-helper cell differentiation (GO:0045623)2.95911291
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.95896269
111negative regulation of cytokine production involved in immune response (GO:0002719)2.95828757
112regulation of T-helper 2 cell differentiation (GO:0045628)2.94401833
113positive regulation of mast cell activation (GO:0033005)2.93401171
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.93167889
115negative regulation of alpha-beta T cell activation (GO:0046636)2.92930650
116positive regulation of isotype switching (GO:0045830)2.92458390
117T cell homeostasis (GO:0043029)2.92299266
118positive regulation of lamellipodium assembly (GO:0010592)2.92221132
119lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90676321
120regulation of response to interferon-gamma (GO:0060330)2.90435293
121response to muramyl dipeptide (GO:0032495)2.89702353
122actin nucleation (GO:0045010)2.89291088
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86794639
124positive regulation of interleukin-2 production (GO:0032743)2.84889768
125positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83715528
126regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.83214148
127mature B cell differentiation (GO:0002335)2.81578810
128macrophage activation involved in immune response (GO:0002281)2.79650969
129natural killer cell activation (GO:0030101)2.78739109
130leukocyte degranulation (GO:0043299)2.78618689
131regulation of antigen processing and presentation (GO:0002577)2.78281143
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75072959
133response to host immune response (GO:0052572)2.75072959
134negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73775144
135ribosomal small subunit assembly (GO:0000028)2.73583852
136positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72651826
137positive regulation of B cell mediated immunity (GO:0002714)2.72651826
138lymphocyte homeostasis (GO:0002260)2.72492810
139regulation of interleukin-2 biosynthetic process (GO:0045076)2.71939210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.73349905
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36972152
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.17662748
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.08774299
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.88512892
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.61412200
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.60272829
8E2F7_22180533_ChIP-Seq_HELA_Human3.15488277
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03063698
10MYC_22102868_ChIP-Seq_BL_Human3.01925784
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87491110
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.87285772
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.86089446
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84695534
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78072824
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73318084
17VDR_21846776_ChIP-Seq_THP-1_Human2.70487838
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70041746
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68448140
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64390738
21SCL_19346495_ChIP-Seq_HPC-7_Human2.63045930
22MYB_26560356_Chip-Seq_TH2_Human2.55532175
23MAF_26560356_Chip-Seq_TH1_Human2.50300493
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46561082
25RUNX_20019798_ChIP-Seq_JUKART_Human2.46509327
26* SPI1_23547873_ChIP-Seq_NB4_Human2.45252755
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42696813
28* UTX_26944678_Chip-Seq_JUKART_Human2.22103132
29MYB_26560356_Chip-Seq_TH1_Human2.18287631
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.18286730
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16837139
32VDR_24763502_ChIP-Seq_THP-1_Human2.14161925
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13054817
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03209478
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95021784
36* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93672100
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.90370056
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87813591
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79300496
40SPI1_23127762_ChIP-Seq_K562_Human1.74981333
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74535172
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71685143
43MAF_26560356_Chip-Seq_TH2_Human1.70599059
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69133412
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67967253
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63426810
47GATA3_27048872_Chip-Seq_THYMUS_Human1.55792844
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.54913784
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50212426
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50116007
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45686444
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45203564
53PU_27001747_Chip-Seq_BMDM_Mouse1.43252954
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42737502
55KDM2B_26808549_Chip-Seq_DND41_Human1.41538339
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37495730
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.37375660
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34811676
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34506632
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30636650
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28942075
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28158687
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26847654
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24825535
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23312216
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22991542
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21614170
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21575794
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21133012
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19161153
71BCOR_27268052_Chip-Seq_Bcells_Human1.17963312
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17539780
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17163234
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15838332
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15773207
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.13896382
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12622838
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10899241
79GATA3_26560356_Chip-Seq_TH2_Human1.10855628
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09459825
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08924352
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08820578
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.08774029
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08694096
85* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08643816
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.07910888
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06863305
88CIITA_25753668_ChIP-Seq_RAJI_Human1.05958253
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04133139
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02877879
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02362956
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.02033836
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.94350460
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92291105
95VDR_23849224_ChIP-Seq_CD4+_Human0.91810198
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91785691
97GATA2_19941826_ChIP-Seq_K562_Human0.91655444
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.91633958
99NCOR1_26117541_ChIP-Seq_K562_Human0.88308458
100LXR_22292898_ChIP-Seq_THP-1_Human0.87292581
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86482238
102BCL6_27268052_Chip-Seq_Bcells_Human0.84639066
103FOXP3_21729870_ChIP-Seq_TREG_Human0.83949970
104TFEB_21752829_ChIP-Seq_HELA_Human0.83794257
105* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81769822
106SPI1_20517297_ChIP-Seq_HL60_Human0.81736841
107VDR_24787735_ChIP-Seq_THP-1_Human0.81554559
108E2F4_17652178_ChIP-ChIP_JURKAT_Human0.80445738
109GATA1_22025678_ChIP-Seq_K562_Human0.80117832
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78447414
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76419270
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.74311238
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73787387
114GATA1_19941826_ChIP-Seq_K562_Human0.73229420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.17821967
2MP0005671_abnormal_response_to3.47636789
3MP0003436_decreased_susceptibility_to3.40811508
4MP0000685_abnormal_immune_system3.34058532
5MP0009785_altered_susceptibility_to3.21805681
6MP0003303_peritoneal_inflammation3.10390076
7MP0001800_abnormal_humoral_immune3.09242112
8MP0003763_abnormal_thymus_physiology3.02924677
9MP0001790_abnormal_immune_system3.01865316
10MP0005387_immune_system_phenotype3.01865316
11MP0005000_abnormal_immune_tolerance3.01227226
12MP0005025_abnormal_response_to2.83828110
13MP0002452_abnormal_antigen_presenting2.82392432
14MP0002723_abnormal_immune_serum2.75091670
15MP0002420_abnormal_adaptive_immunity2.73709310
16MP0002419_abnormal_innate_immunity2.72649998
17MP0001819_abnormal_immune_cell2.72200596
18MP0006082_CNS_inflammation2.58477209
19MP0002148_abnormal_hypersensitivity_rea2.58044661
20MP0002398_abnormal_bone_marrow2.46260785
21MP0003724_increased_susceptibility_to2.36984403
22MP0002405_respiratory_system_inflammati2.35712673
23MP0005464_abnormal_platelet_physiology2.28464195
24MP0009333_abnormal_splenocyte_physiolog2.26915506
25MP0000716_abnormal_immune_system2.26751286
26MP0002166_altered_tumor_susceptibility2.26671050
27MP0004510_myositis2.12683544
28MP0002396_abnormal_hematopoietic_system2.12353996
29MP0000689_abnormal_spleen_morphology2.05084737
30MP0003300_gastrointestinal_ulcer2.02295659
31MP0009278_abnormal_bone_marrow2.01984472
32MP0002722_abnormal_immune_system2.01741023
33MP0010155_abnormal_intestine_physiology1.99592288
34MP0001853_heart_inflammation1.97505654
35MP0002006_tumorigenesis1.92085496
36MP0002429_abnormal_blood_cell1.90823606
37MP0001845_abnormal_inflammatory_respons1.88126636
38MP0004947_skin_inflammation1.85966599
39MP0005397_hematopoietic_system_phenotyp1.79632900
40MP0001545_abnormal_hematopoietic_system1.79632900
41MP0004808_abnormal_hematopoietic_stem1.79272908
42MP0000703_abnormal_thymus_morphology1.74930580
43MP0001873_stomach_inflammation1.74716086
44MP0001533_abnormal_skeleton_physiology1.70606695
45MP0002933_joint_inflammation1.59454438
46MP0000465_gastrointestinal_hemorrhage1.55008849
47MP0000858_altered_metastatic_potential1.53863024
48MP0005058_abnormal_lysosome_morphology1.53609798
49MP0008260_abnormal_autophagy1.49907866
50MP0005310_abnormal_salivary_gland1.48302223
51MP0003866_abnormal_defecation1.43200020
52MP0008469_abnormal_protein_level1.43070286
53MP0003448_altered_tumor_morphology1.41574934
54MP0005174_abnormal_tail_pigmentation1.33532388
55MP0000490_abnormal_crypts_of1.32750476
56MP0005451_abnormal_body_composition1.28516201
57MP0000343_altered_response_to1.27864355
58MP0003172_abnormal_lysosome_physiology1.26055688
59MP0003191_abnormal_cellular_cholesterol1.22455993
60MP0001851_eye_inflammation1.17508580
61MP0009764_decreased_sensitivity_to1.17035795
62MP0008004_abnormal_stomach_pH1.05705989
63MP0004883_abnormal_blood_vessel1.05534361
64MP0002998_abnormal_bone_remodeling1.01013424
65MP0002019_abnormal_tumor_incidence0.99672121
66MP0005075_abnormal_melanosome_morpholog0.96675758
67MP0003183_abnormal_peptide_metabolism0.92338750
68MP0009840_abnormal_foam_cell0.91291796
69MP0002132_abnormal_respiratory_system0.90336665
70MP0003806_abnormal_nucleotide_metabolis0.87487338
71MP0005166_decreased_susceptibility_to0.86715642
72MP0005023_abnormal_wound_healing0.84189310
73MP0003075_altered_response_to0.83813010
74MP0005164_abnormal_response_to0.83704042
75MP0003690_abnormal_glial_cell0.82015255
76MP0010352_gastrointestinal_tract_polyps0.81876337
77MP0010307_abnormal_tumor_latency0.81366866
78MP0009763_increased_sensitivity_to0.80457315
79MP0000604_amyloidosis0.76509323
80MP0003828_pulmonary_edema0.73447712
81MP0005076_abnormal_cell_differentiation0.72549365
82MP0005390_skeleton_phenotype0.72536395
83MP0001986_abnormal_taste_sensitivity0.71905471
84MP0000015_abnormal_ear_pigmentation0.68686651
85MP0001663_abnormal_digestive_system0.68280944
86MP0003566_abnormal_cell_adhesion0.67820166
87MP0002138_abnormal_hepatobiliary_system0.66690812
88MP0000249_abnormal_blood_vessel0.64802455
89MP0008874_decreased_physiological_sensi0.64153170
90MP0003795_abnormal_bone_structure0.63585177
91MP0003693_abnormal_embryo_hatching0.61780972
92MP0002095_abnormal_skin_pigmentation0.59872180
93MP0003656_abnormal_erythrocyte_physiolo0.58896516
94MP0003279_aneurysm0.58723053
95MP0003077_abnormal_cell_cycle0.58072287
96MP0000313_abnormal_cell_death0.57185408
97MP0002136_abnormal_kidney_physiology0.57119005
98MP0003453_abnormal_keratinocyte_physiol0.56593564
99MP0004381_abnormal_hair_follicle0.55481514
100MP0009765_abnormal_xenobiotic_induced0.53947870
101MP0005167_abnormal_blood-brain_barrier0.53315124
102MP0005381_digestive/alimentary_phenotyp0.52321765
103MP0000371_diluted_coat_color0.51757785
104MP0006054_spinal_hemorrhage0.51363891
105MP0002693_abnormal_pancreas_physiology0.50973038
106MP0002277_abnormal_respiratory_mucosa0.50626895
107MP0008873_increased_physiological_sensi0.49096486
108MP0000477_abnormal_intestine_morphology0.48701164
109MP0000609_abnormal_liver_physiology0.48426016
110MP0005319_abnormal_enzyme/_coenzyme0.48280428
111MP0008057_abnormal_DNA_replication0.46560540
112MP0003045_fibrosis0.45822135
113MP0008007_abnormal_cellular_replicative0.45677761
114MP0003091_abnormal_cell_migration0.44979925
115MP0004130_abnormal_muscle_cell0.44528890
116MP0005083_abnormal_biliary_tract0.44425455
117MP0002009_preneoplasia0.42992807
118MP0005535_abnormal_body_temperature0.40066182
119MP0000920_abnormal_myelination0.38752360

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.03487744
2Recurrent abscess formation (HP:0002722)5.99654195
3Recurrent bacterial skin infections (HP:0005406)5.16260442
4Recurrent fungal infections (HP:0002841)4.69487312
5Elevated erythrocyte sedimentation rate (HP:0003565)4.68247848
6Myositis (HP:0100614)4.36385888
7Recurrent gram-negative bacterial infections (HP:0005420)4.21577897
8IgM deficiency (HP:0002850)4.19171345
9Recurrent viral infections (HP:0004429)4.17828706
10T lymphocytopenia (HP:0005403)4.08361690
11Mediastinal lymphadenopathy (HP:0100721)4.05693640
12Abnormality of T cell number (HP:0011839)4.03109172
13Chronic otitis media (HP:0000389)3.96554768
14Obstructive lung disease (HP:0006536)3.95500111
15Chronic obstructive pulmonary disease (HP:0006510)3.95500111
16Stomatitis (HP:0010280)3.95429212
17Recurrent skin infections (HP:0001581)3.90954807
18Recurrent cutaneous fungal infections (HP:0011370)3.86833515
19Chronic mucocutaneous candidiasis (HP:0002728)3.86833515
20Abnormality of macrophages (HP:0004311)3.85546836
21Recurrent bronchitis (HP:0002837)3.78225841
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.73103227
23Meningitis (HP:0001287)3.71391712
24Spontaneous hematomas (HP:0007420)3.61646264
25Abnormality of T cells (HP:0002843)3.58856267
26Autoimmune thrombocytopenia (HP:0001973)3.56843413
27Panhypogammaglobulinemia (HP:0003139)3.54088878
28Cellulitis (HP:0100658)3.51836536
29Nasal polyposis (HP:0100582)3.41662633
30Pustule (HP:0200039)3.35314844
31Abnormality of the nasal mucosa (HP:0000433)3.33074674
32Hypochromic microcytic anemia (HP:0004840)3.29465483
33Severe combined immunodeficiency (HP:0004430)3.25411279
34Orchitis (HP:0100796)3.24907172
35Petechiae (HP:0000967)3.24491886
36Vasculitis (HP:0002633)3.24361572
37Combined immunodeficiency (HP:0005387)3.21987880
38Inflammation of the large intestine (HP:0002037)3.16650649
39Agammaglobulinemia (HP:0004432)3.10793529
40Keratoconjunctivitis (HP:0001096)3.10442998
41Gingivitis (HP:0000230)3.10161974
42Hypochromic anemia (HP:0001931)3.09811596
43Gastrointestinal inflammation (HP:0004386)3.09273742
44Thyroiditis (HP:0100646)3.08632081
45Lymphopenia (HP:0001888)3.02602842
46Leukocytosis (HP:0001974)3.01762349
47Abnormality of T cell physiology (HP:0011840)3.00043749
48Thrombocytosis (HP:0001894)2.98632634
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.96276194
50Optic neuritis (HP:0100653)2.95941613
51Retrobulbar optic neuritis (HP:0100654)2.95941613
52Prolonged bleeding time (HP:0003010)2.91777720
53Vacuolated lymphocytes (HP:0001922)2.90806065
54IgG deficiency (HP:0004315)2.84311450
55Episodic fever (HP:0001954)2.83653455
56Eosinophilia (HP:0001880)2.75654245
57Abnormality of eosinophils (HP:0001879)2.73008314
58Interstitial pulmonary disease (HP:0006530)2.69656902
59Epistaxis (HP:0000421)2.65563617
60Increased cerebral lipofuscin (HP:0011813)2.65540655
61Colitis (HP:0002583)2.63803771
62Urticaria (HP:0001025)2.62394447
63Increased IgE level (HP:0003212)2.61837379
64Hemoptysis (HP:0002105)2.60279701
65Pulmonary embolism (HP:0002204)2.59490705
66Anorexia (HP:0002039)2.53735746
67Granulocytopenia (HP:0001913)2.53496701
68Abnormality of B cell number (HP:0010975)2.53484483
69B lymphocytopenia (HP:0010976)2.53484483
70Encephalitis (HP:0002383)2.52454237
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.50042757
72Pulmonary infiltrates (HP:0002113)2.46497614
73Increased IgM level (HP:0003496)2.45710002
74Gingival bleeding (HP:0000225)2.44702897
75Recurrent sinusitis (HP:0011108)2.43457230
76Abnormality of the fingertips (HP:0001211)2.42878239
77Periodontitis (HP:0000704)2.42386077
78Hypergammaglobulinemia (HP:0010702)2.39090631
79Systemic lupus erythematosus (HP:0002725)2.37857751
80Microcytic anemia (HP:0001935)2.37083944
81Osteomyelitis (HP:0002754)2.36279363
82Gastrointestinal stroma tumor (HP:0100723)2.35739846
83Verrucae (HP:0200043)2.32515219
84Papilloma (HP:0012740)2.32515219
85Hepatosplenomegaly (HP:0001433)2.29805773
86Abnormality of the pleura (HP:0002103)2.28344516
87Chest pain (HP:0100749)2.27757849
88Arterial thrombosis (HP:0004420)2.27535043
89Hematochezia (HP:0002573)2.27335180
90Gangrene (HP:0100758)2.25379261
91Amyloidosis (HP:0011034)2.24258864
92Increased serum ferritin (HP:0003281)2.22229611
93Lymphoma (HP:0002665)2.21464787
94Sepsis (HP:0100806)2.20005916
95Chronic diarrhea (HP:0002028)2.19996327
96Skin ulcer (HP:0200042)2.18496292
97Abnormal platelet function (HP:0011869)2.17804845
98Impaired platelet aggregation (HP:0003540)2.17804845
99Abnormality of glycolipid metabolism (HP:0010969)2.16804403
100Abnormality of liposaccharide metabolism (HP:0010968)2.16804403
101Abnormality of glycosphingolipid metabolism (HP:0004343)2.16804403
102Chronic sinusitis (HP:0011109)2.15393105
103Recurrent pneumonia (HP:0006532)2.15377209
104Abnormal platelet volume (HP:0011876)2.12327351
105Glomerulopathy (HP:0100820)2.12150408
106Recurrent lower respiratory tract infections (HP:0002783)2.10975077
107Autoimmune hemolytic anemia (HP:0001890)2.10133046
108Purpura (HP:0000979)2.09517017
109Emphysema (HP:0002097)2.09004016
110Abnormality of iron homeostasis (HP:0011031)2.08495558
111Keratoconjunctivitis sicca (HP:0001097)2.06930206
112IgA deficiency (HP:0002720)2.06864363
113Bronchitis (HP:0012387)2.05577085
114Restrictive lung disease (HP:0002091)2.04391919
115Loss of speech (HP:0002371)2.03367526
116Peritonitis (HP:0002586)2.03095496
117Joint swelling (HP:0001386)2.02765599
118Gastrointestinal infarctions (HP:0005244)2.02441178
119Cheilitis (HP:0100825)2.01625570
120Premature loss of primary teeth (HP:0006323)2.00785711
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99299871
122Skin rash (HP:0000988)1.96265479
123Abnormality of the peritoneum (HP:0002585)1.94874959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.32053270
2TXK3.58467075
3BLK2.94264783
4ZAP702.73877190
5IRAK42.70769089
6TYK22.64160318
7PRPF4B2.47601557
8JAK32.39693162
9TBK12.37683483
10IKBKE2.31419142
11BTK2.26569665
12STK102.25272930
13KIT2.22171777
14GRK62.14099381
15ERN12.11144479
16TEC1.92722568
17MAP3K141.90714843
18SYK1.84834527
19ITK1.83362810
20CSK1.77984483
21RIPK41.72200989
22MAP3K101.71849770
23CSF1R1.64737022
24JAK11.63841574
25TGFBR21.63524941
26KDR1.63262830
27HCK1.58830649
28MAP3K31.58774685
29NME21.58467802
30LRRK21.55020043
31LCK1.54831552
32FGFR41.51049812
33IKBKB1.47289967
34TESK21.46316973
35IRAK31.40366167
36PKN21.39766482
37CLK11.34187362
38FES1.32023380
39EPHB11.31049793
40EEF2K1.29136025
41RPS6KA41.25200653
42MAP2K31.25083236
43TRIB31.24558597
44PIM11.23621602
45LYN1.19789584
46FGFR31.17778338
47MAP3K11.13748463
48TAOK21.12287658
49NLK1.06769487
50MARK30.98370233
51BMPR20.95659828
52MAP3K130.93710373
53TNK20.93622313
54JAK20.93027923
55SIK20.90988701
56KSR20.89407895
57TAOK30.89406775
58PIM20.88575183
59MAP3K120.82108332
60MARK20.81940607
61FLT30.81604821
62YES10.80524490
63SMG10.80345543
64CDK190.76566398
65CHUK0.76304060
66MST40.73957520
67MAP3K110.73656694
68TGFBR10.68646299
69PDPK10.65703326
70STK40.65297099
71CDK120.65233700
72PRKCQ0.64776028
73CDC42BPA0.63938433
74FGR0.63003410
75IRAK20.60648280
76CDK40.60339972
77PTK60.58632906
78SIK30.58382067
79PRKCH0.58134611
80PAK40.58082415
81TRPM70.56065513
82SIK10.55627553
83MAPK70.55605701
84GRK70.53567975
85MATK0.50323920
86NEK90.49964419
87CAMKK10.49089328
88ALK0.48208958
89PTK2B0.47785147
90CAMKK20.47359944
91DYRK1B0.46887419
92RPS6KA60.46828751
93TAOK10.46707507
94HIPK20.46377662
95MAPK40.45923937
96MAP3K50.45175645
97MAPKAPK20.43561198
98PDK10.41423071
99NEK20.41299944
100MAPK110.40340701
101PRKG20.39785448
102ABL10.39378989
103PRKCD0.38694713
104MAP3K60.38308690
105MAP3K80.36912435
106CDK60.36722915
107FYN0.36173621
108PIK3CG0.36065503
109RPS6KC10.35065812
110RPS6KL10.35065812
111RET0.34875135
112TESK10.34222698
113TTN0.34054871
114EGFR0.33475882
115STK110.33163719
116MAP2K60.32930228
117MAP2K20.32604625
118CDK90.29412408
119BMX0.27651159
120IRAK10.26604183
121MAP3K70.25699530
122MAPK120.24129881
123EPHA30.23700481
124STK240.22406008
125PRKD20.22362944
126ILK0.22196397
127CAMK1D0.20806459

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.80309126
2Leishmaniasis_Homo sapiens_hsa051403.01312611
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.45720444
4Osteoclast differentiation_Homo sapiens_hsa043802.44241009
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.43528200
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43431925
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.39846247
8B cell receptor signaling pathway_Homo sapiens_hsa046622.34993691
9Measles_Homo sapiens_hsa051622.34779036
10Antigen processing and presentation_Homo sapiens_hsa046122.23279013
11Hematopoietic cell lineage_Homo sapiens_hsa046402.18942865
12Staphylococcus aureus infection_Homo sapiens_hsa051502.14045020
13T cell receptor signaling pathway_Homo sapiens_hsa046602.11736085
14Graft-versus-host disease_Homo sapiens_hsa053322.03831668
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89983681
16Allograft rejection_Homo sapiens_hsa053301.89479564
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84277344
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81197243
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80774194
20Asthma_Homo sapiens_hsa053101.78217138
21Herpes simplex infection_Homo sapiens_hsa051681.67409792
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.63289817
23Tuberculosis_Homo sapiens_hsa051521.61929975
24Shigellosis_Homo sapiens_hsa051311.61615785
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58335822
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57807730
27Pertussis_Homo sapiens_hsa051331.56662432
28Legionellosis_Homo sapiens_hsa051341.53593130
29Toxoplasmosis_Homo sapiens_hsa051451.51647636
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51611447
31Chemokine signaling pathway_Homo sapiens_hsa040621.47947831
32Other glycan degradation_Homo sapiens_hsa005111.47769929
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.45906973
34Malaria_Homo sapiens_hsa051441.44938170
35Acute myeloid leukemia_Homo sapiens_hsa052211.39921080
36Influenza A_Homo sapiens_hsa051641.39459709
37Ribosome_Homo sapiens_hsa030101.31905018
38Viral myocarditis_Homo sapiens_hsa054161.31163752
39Hepatitis B_Homo sapiens_hsa051611.30676947
40Apoptosis_Homo sapiens_hsa042101.28923039
41TNF signaling pathway_Homo sapiens_hsa046681.27504789
42Salmonella infection_Homo sapiens_hsa051321.27114165
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18368788
44Platelet activation_Homo sapiens_hsa046111.12828149
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.08602004
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08267482
47DNA replication_Homo sapiens_hsa030301.07211119
48Lysosome_Homo sapiens_hsa041421.05332425
49Pancreatic cancer_Homo sapiens_hsa052121.01113847
50Chronic myeloid leukemia_Homo sapiens_hsa052201.00123332
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99083631
52Autoimmune thyroid disease_Homo sapiens_hsa053200.98739820
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94294362
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90363970
55Epstein-Barr virus infection_Homo sapiens_hsa051690.89760826
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89657779
57Rheumatoid arthritis_Homo sapiens_hsa053230.87667943
58Base excision repair_Homo sapiens_hsa034100.84297436
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84074503
60Hepatitis C_Homo sapiens_hsa051600.81579712
61HTLV-I infection_Homo sapiens_hsa051660.78069855
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.74152738
63Caffeine metabolism_Homo sapiens_hsa002320.73817659
64Viral carcinogenesis_Homo sapiens_hsa052030.70472193
65VEGF signaling pathway_Homo sapiens_hsa043700.69520496
66Mismatch repair_Homo sapiens_hsa034300.69215168
67Prolactin signaling pathway_Homo sapiens_hsa049170.67080539
68Phagosome_Homo sapiens_hsa041450.64710689
69Colorectal cancer_Homo sapiens_hsa052100.63125246
70Type I diabetes mellitus_Homo sapiens_hsa049400.61442564
71Non-small cell lung cancer_Homo sapiens_hsa052230.59797392
72African trypanosomiasis_Homo sapiens_hsa051430.59186215
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.56465046
74Notch signaling pathway_Homo sapiens_hsa043300.55133018
75Endocytosis_Homo sapiens_hsa041440.53023325
76p53 signaling pathway_Homo sapiens_hsa041150.51707951
77Small cell lung cancer_Homo sapiens_hsa052220.50003657
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49955095
79Pentose phosphate pathway_Homo sapiens_hsa000300.49823915
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49022573
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46896528
82Choline metabolism in cancer_Homo sapiens_hsa052310.46512392
83Spliceosome_Homo sapiens_hsa030400.46358607
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45729209
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.45408327
86Non-homologous end-joining_Homo sapiens_hsa034500.43372510
87Endometrial cancer_Homo sapiens_hsa052130.43007910
88HIF-1 signaling pathway_Homo sapiens_hsa040660.39353222
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.39102518
90Homologous recombination_Homo sapiens_hsa034400.38726235
91GnRH signaling pathway_Homo sapiens_hsa049120.37598830
92Amoebiasis_Homo sapiens_hsa051460.37538858
93FoxO signaling pathway_Homo sapiens_hsa040680.36484523
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36081168
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35016839
96Regulation of autophagy_Homo sapiens_hsa041400.33725270
97Systemic lupus erythematosus_Homo sapiens_hsa053220.31363820
98Insulin resistance_Homo sapiens_hsa049310.31211825
99mTOR signaling pathway_Homo sapiens_hsa041500.30036090
100Inositol phosphate metabolism_Homo sapiens_hsa005620.29540388
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29208271
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.26730572
103Type II diabetes mellitus_Homo sapiens_hsa049300.26358941
104Collecting duct acid secretion_Homo sapiens_hsa049660.25993595
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25435424
106Sulfur relay system_Homo sapiens_hsa041220.24498716
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24071002
108Pathways in cancer_Homo sapiens_hsa052000.23519551
109Dorso-ventral axis formation_Homo sapiens_hsa043200.23464311
110MAPK signaling pathway_Homo sapiens_hsa040100.23234312
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22325594
112Rap1 signaling pathway_Homo sapiens_hsa040150.21957542
113Proteoglycans in cancer_Homo sapiens_hsa052050.21727842
114Nucleotide excision repair_Homo sapiens_hsa034200.21184568
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20319305
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20101214
117Renal cell carcinoma_Homo sapiens_hsa052110.18646288

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