GPT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26370121
2L-phenylalanine catabolic process (GO:0006559)7.26370121
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.94491755
4L-phenylalanine metabolic process (GO:0006558)6.94491755
5aromatic amino acid family catabolic process (GO:0009074)6.40755997
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.96561209
7alpha-linolenic acid metabolic process (GO:0036109)5.79926338
8tryptophan catabolic process (GO:0006569)5.68348555
9indole-containing compound catabolic process (GO:0042436)5.68348555
10indolalkylamine catabolic process (GO:0046218)5.68348555
11kynurenine metabolic process (GO:0070189)5.66525268
12bile acid biosynthetic process (GO:0006699)5.66164855
13urea metabolic process (GO:0019627)5.54867477
14urea cycle (GO:0000050)5.54867477
15sulfur amino acid catabolic process (GO:0000098)5.49374110
16glyoxylate metabolic process (GO:0046487)5.36689116
17tryptophan metabolic process (GO:0006568)5.35707202
18cysteine metabolic process (GO:0006534)5.28111302
19complement activation, alternative pathway (GO:0006957)5.25517407
20high-density lipoprotein particle remodeling (GO:0034375)5.18495464
21negative regulation of fibrinolysis (GO:0051918)5.15028900
22regulation of protein activation cascade (GO:2000257)5.11623689
23serine family amino acid catabolic process (GO:0009071)5.10864109
24nitrogen cycle metabolic process (GO:0071941)5.09806973
25peptidyl-glutamic acid carboxylation (GO:0017187)5.03891820
26protein carboxylation (GO:0018214)5.03891820
27regulation of fibrinolysis (GO:0051917)4.92305690
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89378400
29bile acid metabolic process (GO:0008206)4.85667074
30homocysteine metabolic process (GO:0050667)4.82586904
31regulation of complement activation (GO:0030449)4.80472252
32regulation of triglyceride catabolic process (GO:0010896)4.79365432
33lysine metabolic process (GO:0006553)4.73853320
34lysine catabolic process (GO:0006554)4.73853320
35L-serine metabolic process (GO:0006563)4.71007455
36aromatic amino acid family metabolic process (GO:0009072)4.61664673
37reverse cholesterol transport (GO:0043691)4.60728802
38tyrosine metabolic process (GO:0006570)4.56062584
39* alpha-amino acid catabolic process (GO:1901606)4.55957000
40amino-acid betaine metabolic process (GO:0006577)4.55286153
41acylglycerol homeostasis (GO:0055090)4.50922397
42triglyceride homeostasis (GO:0070328)4.50922397
43plasma lipoprotein particle remodeling (GO:0034369)4.49653456
44protein-lipid complex remodeling (GO:0034368)4.49653456
45macromolecular complex remodeling (GO:0034367)4.49653456
46negative regulation of sterol transport (GO:0032372)4.39296827
47negative regulation of cholesterol transport (GO:0032375)4.39296827
48regulation of cholesterol esterification (GO:0010872)4.39217976
49coenzyme catabolic process (GO:0009109)4.36423513
50glycine metabolic process (GO:0006544)4.31581909
51plasma lipoprotein particle clearance (GO:0034381)4.30501475
52* cellular amino acid catabolic process (GO:0009063)4.27912916
53cellular modified amino acid catabolic process (GO:0042219)4.22960585
54glutamate metabolic process (GO:0006536)4.21597168
55ethanol oxidation (GO:0006069)4.16605715
56serine family amino acid metabolic process (GO:0009069)4.15989504
57phospholipid efflux (GO:0033700)4.15093663
58cellular ketone body metabolic process (GO:0046950)4.14719029
59bile acid and bile salt transport (GO:0015721)4.05437145
60acetyl-CoA metabolic process (GO:0006084)4.04366478
61cellular glucuronidation (GO:0052695)3.99589049
62dicarboxylic acid biosynthetic process (GO:0043650)3.99503322
63indolalkylamine metabolic process (GO:0006586)3.97578321
64imidazole-containing compound metabolic process (GO:0052803)3.93937414
65serine family amino acid biosynthetic process (GO:0009070)3.93661013
66intestinal cholesterol absorption (GO:0030299)3.91616078
67cholesterol efflux (GO:0033344)3.91208588
68cellular biogenic amine catabolic process (GO:0042402)3.88057372
69amine catabolic process (GO:0009310)3.88057372
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.86734364
71positive regulation of lipid catabolic process (GO:0050996)3.84282262
72short-chain fatty acid metabolic process (GO:0046459)3.83816328
73proline metabolic process (GO:0006560)3.83476047
74arginine metabolic process (GO:0006525)3.79084503
75benzene-containing compound metabolic process (GO:0042537)3.78926218
76* organic acid catabolic process (GO:0016054)3.75408200
77* carboxylic acid catabolic process (GO:0046395)3.75408200
78drug catabolic process (GO:0042737)3.73265211
79phospholipid homeostasis (GO:0055091)3.72397025
80regulation of cholesterol homeostasis (GO:2000188)3.70942378
81plasma lipoprotein particle assembly (GO:0034377)3.67654007
82cytolysis (GO:0019835)3.67169202
83fibrinolysis (GO:0042730)3.65460970
84negative regulation of lipase activity (GO:0060192)3.64670466
85valine metabolic process (GO:0006573)3.63674879
86low-density lipoprotein particle remodeling (GO:0034374)3.63219806
87aspartate family amino acid catabolic process (GO:0009068)3.60964177
88regulation of cholesterol biosynthetic process (GO:0045540)3.60717896
89regulation of bile acid biosynthetic process (GO:0070857)3.59450218
90ketone body metabolic process (GO:1902224)3.58375210
91protein-lipid complex assembly (GO:0065005)3.55626258
92fatty acid beta-oxidation (GO:0006635)3.55113228
93cholesterol homeostasis (GO:0042632)3.54489450
94fatty acid oxidation (GO:0019395)3.54394669
95complement activation (GO:0006956)3.54338263
96complement activation, classical pathway (GO:0006958)3.53859268
97very-low-density lipoprotein particle assembly (GO:0034379)3.51839335
98positive regulation of lipoprotein lipase activity (GO:0051006)3.51703499
99positive regulation of triglyceride lipase activity (GO:0061365)3.51703499
100monocarboxylic acid catabolic process (GO:0072329)3.51686878
101uronic acid metabolic process (GO:0006063)3.49491317
102glucuronate metabolic process (GO:0019585)3.49491317
103sterol homeostasis (GO:0055092)3.49376713
104cofactor catabolic process (GO:0051187)3.48943335
105lipid oxidation (GO:0034440)3.48095504
106embryonic retina morphogenesis in camera-type eye (GO:0060059)3.39587794
107proline biosynthetic process (GO:0006561)3.34592835
108fatty acid homeostasis (GO:0055089)3.28707445
109regulation of plasminogen activation (GO:0010755)3.27861135
110biotin metabolic process (GO:0006768)3.24065286
111blood coagulation, intrinsic pathway (GO:0007597)3.20736374
112plasma lipoprotein particle organization (GO:0071827)3.14747663
113protein-lipid complex subunit organization (GO:0071825)3.07926351
114creatine metabolic process (GO:0006600)3.06278116
115regulation of apoptotic cell clearance (GO:2000425)3.04917811
116gluconeogenesis (GO:0006094)2.96211812
1174-hydroxyproline metabolic process (GO:0019471)2.93618062
118oxaloacetate metabolic process (GO:0006107)2.89303474
119response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.88777537
120acylglycerol catabolic process (GO:0046464)2.88494421
121neutral lipid catabolic process (GO:0046461)2.88494421
122lung epithelium development (GO:0060428)2.88153673
123hexose biosynthetic process (GO:0019319)2.87249816
124NADH metabolic process (GO:0006734)2.85689549
125low-density lipoprotein particle clearance (GO:0034383)2.84507292
126diacylglycerol metabolic process (GO:0046339)2.78928389
127glycogen catabolic process (GO:0005980)2.72287154
128response to muscle activity (GO:0014850)2.66376731
129regulation of cholesterol metabolic process (GO:0090181)2.61179969
130monosaccharide biosynthetic process (GO:0046364)2.60767614
131ethanol metabolic process (GO:0006067)2.59048998
132response to mercury ion (GO:0046689)2.57254602
133muscle filament sliding (GO:0030049)2.54463249
134actin-myosin filament sliding (GO:0033275)2.54463249
135triglyceride catabolic process (GO:0019433)2.53101453
136positive regulation of synapse maturation (GO:0090129)2.51055961
137sarcoplasmic reticulum calcium ion transport (GO:0070296)2.48928938
138central nervous system myelination (GO:0022010)2.47064280
139axon ensheathment in central nervous system (GO:0032291)2.47064280
140glutamine family amino acid catabolic process (GO:0009065)2.43765168
141glutamine family amino acid biosynthetic process (GO:0009084)2.43497723
142positive regulation of fatty acid biosynthetic process (GO:0045723)2.39847184
143glucan catabolic process (GO:0009251)2.39048101
144regulation of fatty acid biosynthetic process (GO:0042304)2.38544909
145positive regulation of dendritic spine morphogenesis (GO:0061003)2.37907445
146exogenous drug catabolic process (GO:0042738)2.34947760
147negative regulation of lipid transport (GO:0032369)2.33541112
148negative regulation of fatty acid biosynthetic process (GO:0045717)2.31949899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.94599868
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.81547430
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.27517433
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.19002534
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.74531177
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08334837
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.54403205
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.10200892
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51878951
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49540407
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29212653
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17232775
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.12576060
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09037134
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02398529
16* CLOCK_20551151_ChIP-Seq_293T_Human2.01797082
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2728093
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87428267
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87181331
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83277393
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75082490
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.74461919
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61883188
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60889544
25POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57108437
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54543077
27EZH2_22144423_ChIP-Seq_EOC_Human1.50181392
28CTCF_27219007_Chip-Seq_Bcells_Human1.47214826
29KDM2B_26808549_Chip-Seq_K562_Human1.45262916
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.41223550
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40848604
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39157769
33HTT_18923047_ChIP-ChIP_STHdh_Human1.34976189
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.32551294
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32245413
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30048157
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28159948
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26576693
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24961645
40* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20941590
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20713351
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20713351
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20388790
44SMC4_20622854_ChIP-Seq_HELA_Human1.19854961
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18990959
46GATA1_22025678_ChIP-Seq_K562_Human1.18209089
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17895214
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.16806183
49AR_21909140_ChIP-Seq_LNCAP_Human1.16509897
50ZNF263_19887448_ChIP-Seq_K562_Human1.15747280
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12427956
52* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11919076
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11665409
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10186179
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.08105915
56* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07674640
57P68_20966046_ChIP-Seq_HELA_Human1.07278209
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06750550
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06431422
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05915233
61AR_21572438_ChIP-Seq_LNCaP_Human1.05577331
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.03702311
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02806541
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01531058
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01363620
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99903842
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97210101
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96424928
69RING1B_27294783_Chip-Seq_NPCs_Mouse0.95561120
70TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95150527
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95137507
72* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95063132
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95005429
74SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94550003
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93559115
76TET1_21451524_ChIP-Seq_MESCs_Mouse0.93096199
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90965599
78DROSHA_22980978_ChIP-Seq_HELA_Human0.90849235
79* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90770661
80TP53_20018659_ChIP-ChIP_R1E_Mouse0.90214673
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89842354
82MYC_18555785_ChIP-Seq_MESCs_Mouse0.89198226
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88880293
84NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87718141
85SOX3_22085726_ChIP-Seq_NPCs_Mouse0.86557407
86SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86551430
87RING1B_27294783_Chip-Seq_ESCs_Mouse0.86322081
88* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85244189
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85040769
90* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84636095
91* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84070503
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83954487
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83947880
94ISL1_27105846_Chip-Seq_CPCs_Mouse0.83725414
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83361722
96ESR1_21235772_ChIP-Seq_MCF-7_Human0.82919156
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82080844
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81789312
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81232071
100* GATA4_25053715_ChIP-Seq_YYC3_Human0.81103292
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81000938
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.80812977
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80435284
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79974091
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.79594963
106* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73674563
107* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73674563
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70464755
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68765201
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68362644
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.67560795
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.66067033
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65991807
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62293959
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.61756423
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60318838
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.60056262
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.58384655
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.56646186
120* LXR_22292898_ChIP-Seq_THP-1_Human0.56522082
121CEBPB_22108803_ChIP-Seq_LS180_Human0.56210051
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55942093
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.54654790
124CBP_21632823_ChIP-Seq_H3396_Human0.54551069
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53621234
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.52904142
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.51161833
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.50816031
129* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.50094906
130BCAT_22108803_ChIP-Seq_LS180_Human0.49928786
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.49146868
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48249213
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.48151285
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47491307
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.46675604
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.46196025
137GATA6_25053715_ChIP-Seq_YYC3_Human0.46040255
138MYC_19915707_ChIP-ChIP_AK7_Human0.45867446
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.45691318
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.45542615
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.45542615
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.44898903
143* GATA3_24758297_ChIP-Seq_MCF-7_Human0.44844923
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44748112
145P53_21459846_ChIP-Seq_SAOS-2_Human0.44485943
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.44210003
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.43823329
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.43732701
149CDX2_22108803_ChIP-Seq_LS180_Human0.43639012
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.43444670
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.43429663
152* SOX2_20726797_ChIP-Seq_SW620_Human0.43263959
153* CREB1_26743006_Chip-Seq_LNCaP_Human0.43219065
154* ESET_19884257_ChIP-Seq_ESCs_Mouse0.42997092
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.42847577
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41294718
157RACK7_27058665_Chip-Seq_MCF-7_Human0.41099983
158AR_20517297_ChIP-Seq_VCAP_Human0.40745201
159TRIM28_21343339_ChIP-Seq_HEK293_Human0.38814971
160NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.38540981
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.38128648
162* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38031846
163* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.37933384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14176696
2MP0005360_urolithiasis7.16975343
3MP0005085_abnormal_gallbladder_physiolo6.22608674
4MP0005365_abnormal_bile_salt6.14838666
5MP0008875_abnormal_xenobiotic_pharmacok4.87328811
6MP0003806_abnormal_nucleotide_metabolis4.07864470
7MP0003252_abnormal_bile_duct3.85346276
8MP0010329_abnormal_lipoprotein_level3.67273525
9MP0000566_synostosis3.41076099
10MP0009840_abnormal_foam_cell2.98917033
11MP0005083_abnormal_biliary_tract2.91636617
12MP0003122_maternal_imprinting2.88242988
13MP0005332_abnormal_amino_acid2.83567570
14MP0001666_abnormal_nutrient_absorption2.59821103
15MP0003195_calcinosis2.48422402
16MP0000751_myopathy2.28159346
17MP0003123_paternal_imprinting2.25387722
18MP0002118_abnormal_lipid_homeostasis2.22101075
19MP0003191_abnormal_cellular_cholesterol2.20445301
20MP0000609_abnormal_liver_physiology2.15767528
21MP0003646_muscle_fatigue2.06555469
22MP0004270_analgesia1.98585968
23MP0004019_abnormal_vitamin_homeostasis1.97782863
24MP0004145_abnormal_muscle_electrophysio1.92782003
25MP0003868_abnormal_feces_composition1.92050304
26MP0005319_abnormal_enzyme/_coenzyme1.83460918
27MP0004233_abnormal_muscle_weight1.71139490
28MP0005670_abnormal_white_adipose1.69305774
29MP0002138_abnormal_hepatobiliary_system1.66022758
30MP0003705_abnormal_hypodermis_morpholog1.62664414
31MP0002089_abnormal_postnatal_growth/wei1.60703737
32MP0000749_muscle_degeneration1.56785990
33MP0004130_abnormal_muscle_cell1.55165297
34MP0005584_abnormal_enzyme/coenzyme_acti1.54132945
35MP0001764_abnormal_homeostasis1.52282299
36MP0004087_abnormal_muscle_fiber1.51530605
37MP0010030_abnormal_orbit_morphology1.47717569
38MP0004858_abnormal_nervous_system1.46405451
39MP0002249_abnormal_larynx_morphology1.44118239
40MP0005647_abnormal_sex_gland1.40463790
41MP0002106_abnormal_muscle_physiology1.33076494
42MP0005451_abnormal_body_composition1.30060087
43MP0003011_delayed_dark_adaptation1.23411341
44MP0009643_abnormal_urine_homeostasis1.22513237
45MP0003186_abnormal_redox_activity1.21783679
46MP0003942_abnormal_urinary_system1.20802188
47MP0003941_abnormal_skin_development1.20174244
48MP0004859_abnormal_synaptic_plasticity1.19994972
49MP0005369_muscle_phenotype1.19391537
50MP0009697_abnormal_copulation1.17369980
51MP0003890_abnormal_embryonic-extraembry1.16606224
52MP0002697_abnormal_eye_size1.15794898
53MP0000759_abnormal_skeletal_muscle1.15601262
54MP0005666_abnormal_adipose_tissue1.13421241
55MP0003656_abnormal_erythrocyte_physiolo1.13296791
56MP0003121_genomic_imprinting1.13139274
57MP0000598_abnormal_liver_morphology1.11564596
58MP0000762_abnormal_tongue_morphology1.10579078
59MP0003136_yellow_coat_color1.07279625
60MP0001299_abnormal_eye_distance/1.05378467
61MP0010630_abnormal_cardiac_muscle1.05170095
62MP0005423_abnormal_somatic_nervous1.04586264
63MP0002254_reproductive_system_inflammat1.04340101
64MP0002971_abnormal_brown_adipose1.03530029
65MP0004036_abnormal_muscle_relaxation1.00323855
66MP0001346_abnormal_lacrimal_gland0.99786170
67MP0000604_amyloidosis0.99029065
68MP0003315_abnormal_perineum_morphology0.97764349
69MP0005076_abnormal_cell_differentiation0.97193496
70MP0003567_abnormal_fetal_cardiomyocyte0.97143178
71MP0006292_abnormal_olfactory_placode0.97140696
72MP0003119_abnormal_digestive_system0.96915985
73MP0009764_decreased_sensitivity_to0.96218059
74MP0005330_cardiomyopathy0.96071041
75MP0002876_abnormal_thyroid_physiology0.95412867
76MP0003879_abnormal_hair_cell0.94345175
77MP0006138_congestive_heart_failure0.93805990
78MP0004272_abnormal_basement_membrane0.93302503
79MP0005409_darkened_coat_color0.93249757
80MP0005334_abnormal_fat_pad0.92823683
81MP0000003_abnormal_adipose_tissue0.90556146
82MP0003115_abnormal_respiratory_system0.89658636
83MP0003690_abnormal_glial_cell0.89361883
84MP0002837_dystrophic_cardiac_calcinosis0.89253740
85MP0002078_abnormal_glucose_homeostasis0.89035688
86MP0010234_abnormal_vibrissa_follicle0.88920211
87MP0001661_extended_life_span0.88713991
88MP0002108_abnormal_muscle_morphology0.87809353
89MP0004133_heterotaxia0.87737541
90MP0009763_increased_sensitivity_to0.87144385
91MP0005636_abnormal_mineral_homeostasis0.85053938
92MP0000534_abnormal_ureter_morphology0.84561588
93MP0006036_abnormal_mitochondrial_physio0.83617464
94MP0003937_abnormal_limbs/digits/tail_de0.82817466
95MP0005220_abnormal_exocrine_pancreas0.82704051
96MP0000955_abnormal_spinal_cord0.81422114
97MP0000537_abnormal_urethra_morphology0.81057071
98MP0001915_intracranial_hemorrhage0.80238523
99MP0003861_abnormal_nervous_system0.80233280
100MP0000778_abnormal_nervous_system0.79998908
101MP0009642_abnormal_blood_homeostasis0.79630166
102MP0002233_abnormal_nose_morphology0.77672758
103MP0001529_abnormal_vocalization0.77314163
104MP0005535_abnormal_body_temperature0.77124088
105MP0005257_abnormal_intraocular_pressure0.76893215
106MP0004185_abnormal_adipocyte_glucose0.76446722
107MP0005376_homeostasis/metabolism_phenot0.75775473
108MP0009765_abnormal_xenobiotic_induced0.74059735
109MP0005620_abnormal_muscle_contractility0.73796480
110MP0003329_amyloid_beta_deposits0.72511538
111MP0001730_embryonic_growth_arrest0.71723622
112MP0001984_abnormal_olfaction0.70693606
113MP0002092_abnormal_eye_morphology0.70581719
114MP0001756_abnormal_urination0.70439281
115MP0001293_anophthalmia0.69820900
116MP0004197_abnormal_fetal_growth/weight/0.69515575
117MP0003878_abnormal_ear_physiology0.68455554
118MP0005377_hearing/vestibular/ear_phenot0.68455554
119MP0009703_decreased_birth_body0.68439074
120MP0001286_abnormal_eye_development0.68349999
121MP0002938_white_spotting0.68070855
122MP0005266_abnormal_metabolism0.67931026
123MP0000467_abnormal_esophagus_morphology0.67858107
124MP0000733_abnormal_muscle_development0.67415486
125MP0000750_abnormal_muscle_regeneration0.66328931
126MP0009053_abnormal_anal_canal0.65107796
127MP0003938_abnormal_ear_development0.65046221
128MP0002234_abnormal_pharynx_morphology0.64608158
129MP0005408_hypopigmentation0.64486926
130MP0005448_abnormal_energy_balance0.64131059
131MP0008469_abnormal_protein_level0.63168690
132MP0010368_abnormal_lymphatic_system0.61694453
133MP0005248_abnormal_Harderian_gland0.58798371
134MP0009384_cardiac_valve_regurgitation0.58254245
135MP0005084_abnormal_gallbladder_morpholo0.58075805
136MP0005375_adipose_tissue_phenotype0.56980276
137MP0009115_abnormal_fat_cell0.54959439
138MP0006035_abnormal_mitochondrial_morpho0.54037049
139MP0002796_impaired_skin_barrier0.53458382
140MP0000639_abnormal_adrenal_gland0.52894697
141MP0002269_muscular_atrophy0.52497139
142MP0005395_other_phenotype0.48998971
143MP0009672_abnormal_birth_weight0.47200219
144MP0003953_abnormal_hormone_level0.47058977
145MP0002970_abnormal_white_adipose0.45808886
146MP0001881_abnormal_mammary_gland0.45619032
147MP0002822_catalepsy0.42051580
148MP0008874_decreased_physiological_sensi0.41707850
149MP0003959_abnormal_lean_body0.41180393
150MP0000579_abnormal_nail_morphology0.40994811
151MP0002136_abnormal_kidney_physiology0.40366563
152MP0003718_maternal_effect0.39557491
153MP0003638_abnormal_response/metabolism_0.38681791
154MP0002168_other_aberrant_phenotype0.38639088
155MP0003075_altered_response_to0.38463607
156MP0000427_abnormal_hair_cycle0.37804327
157MP0002060_abnormal_skin_morphology0.36665965
158MP0004043_abnormal_pH_regulation0.36344179
159MP0005166_decreased_susceptibility_to0.34244401
160MP0002928_abnormal_bile_duct0.34134294
161MP0000230_abnormal_systemic_arterial0.33076431
162MP0005187_abnormal_penis_morphology0.31782712
163MP0009780_abnormal_chondrocyte_physiolo0.31221594
164MP0008873_increased_physiological_sensi0.30894266
165MP0000747_muscle_weakness0.30741701
166MP0003300_gastrointestinal_ulcer0.30450446
167MP0002090_abnormal_vision0.29764610
168MP0008872_abnormal_physiological_respon0.29549348
169MP0005452_abnormal_adipose_tissue0.28712766
170MP0008438_abnormal_cutaneous_collagen0.28026416

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.14027870
2Intrahepatic cholestasis (HP:0001406)7.01353011
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.94589753
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.48630048
5Xanthomatosis (HP:0000991)6.18629286
6Hypobetalipoproteinemia (HP:0003563)6.09777364
7Prolonged partial thromboplastin time (HP:0003645)6.02745154
8Complement deficiency (HP:0004431)5.50017490
9Hyperlipoproteinemia (HP:0010980)5.46005511
10Hypolipoproteinemia (HP:0010981)4.81206115
11Hyperglycinemia (HP:0002154)4.79310254
12Hyperammonemia (HP:0001987)4.73201501
13Epidermoid cyst (HP:0200040)4.62627199
14Nemaline bodies (HP:0003798)4.60093985
15Muscle fiber inclusion bodies (HP:0100299)4.57434264
16Ketosis (HP:0001946)4.51194073
17Hyperglycinuria (HP:0003108)4.50994086
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.44828795
19Abnormality of glycine metabolism (HP:0010895)4.44144858
20Abnormality of serine family amino acid metabolism (HP:0010894)4.44144858
21Hypoalphalipoproteinemia (HP:0003233)4.43300625
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41933897
23Abnormality of the common coagulation pathway (HP:0010990)4.22774656
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.22196608
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.19548258
26Joint hemorrhage (HP:0005261)4.17161919
27Abnormality of methionine metabolism (HP:0010901)4.07024866
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97668096
29Exercise-induced myalgia (HP:0003738)3.94921320
30Abnormality of complement system (HP:0005339)3.93206312
31Fat malabsorption (HP:0002630)3.91656557
32Hypoglycemic coma (HP:0001325)3.75098446
33Abnormality of the intrinsic pathway (HP:0010989)3.71642340
34Abnormality of pyrimidine metabolism (HP:0004353)3.61410156
35Exercise-induced muscle cramps (HP:0003710)3.59230749
36Hypercholesterolemia (HP:0003124)3.51653011
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46010013
38Abnormality of fatty-acid metabolism (HP:0004359)3.41017153
39Type 1 muscle fiber predominance (HP:0003803)3.39855815
40Conjugated hyperbilirubinemia (HP:0002908)3.33134093
41Ketoacidosis (HP:0001993)3.27428874
42Abnormality of serum amino acid levels (HP:0003112)3.20093759
43Myopathic facies (HP:0002058)3.14605301
44Abnormality of nucleobase metabolism (HP:0010932)3.05531129
45Hyperbilirubinemia (HP:0002904)2.99969912
46Delayed CNS myelination (HP:0002188)2.98789929
47Hepatocellular carcinoma (HP:0001402)2.96168978
48Myocardial infarction (HP:0001658)2.95081766
49Steatorrhea (HP:0002570)2.93894281
50Skin nodule (HP:0200036)2.88093600
51Spastic diplegia (HP:0001264)2.85973415
52Spontaneous abortion (HP:0005268)2.78718362
53Abnormality of purine metabolism (HP:0004352)2.77591616
54Metabolic acidosis (HP:0001942)2.66687412
55Hepatoblastoma (HP:0002884)2.62277232
56Calcaneovalgus deformity (HP:0001848)2.61016738
57Gout (HP:0001997)2.59016958
58Hypochromic microcytic anemia (HP:0004840)2.57888013
59Bronchomalacia (HP:0002780)2.57195746
60Lethargy (HP:0001254)2.55296385
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47198299
62Dicarboxylic aciduria (HP:0003215)2.47198299
63Abnormal gallbladder morphology (HP:0012437)2.45790139
64Rhabdomyolysis (HP:0003201)2.45075785
65Systemic lupus erythematosus (HP:0002725)2.45059617
66Cholelithiasis (HP:0001081)2.43386096
67Abnormality of glycolysis (HP:0004366)2.42908593
68Distal arthrogryposis (HP:0005684)2.42158840
69Muscle hypertrophy of the lower extremities (HP:0008968)2.41936943
70Increased serum pyruvate (HP:0003542)2.39174544
71Neonatal onset (HP:0003623)2.38731847
72Vascular calcification (HP:0004934)2.38629668
73Hypoglycemic seizures (HP:0002173)2.37551598
74Cholecystitis (HP:0001082)2.32868505
75Abnormal gallbladder physiology (HP:0012438)2.32868505
76Cerebral edema (HP:0002181)2.31080217
77Acanthocytosis (HP:0001927)2.28349243
78Sensorimotor neuropathy (HP:0007141)2.26522250
79Irritability (HP:0000737)2.24101404
80Deformed tarsal bones (HP:0008119)2.22306311
81Malnutrition (HP:0004395)2.21038880
82Pancreatitis (HP:0001733)2.17560676
83Mitral stenosis (HP:0001718)2.16293900
84Brushfield spots (HP:0001088)2.15595695
85Pterygium (HP:0001059)2.15495029
86Cardiovascular calcification (HP:0011915)2.15356679
87Round ear (HP:0100830)2.15351687
88Amyloidosis (HP:0011034)2.15168681
89Small epiphyses (HP:0010585)2.13527316
90Esophageal varix (HP:0002040)2.12772280
91Bifid scrotum (HP:0000048)2.12415825
92Aplasia involving bones of the extremities (HP:0009825)2.11693748
93Aplasia involving bones of the upper limbs (HP:0009823)2.11693748
94Aplasia of the phalanges of the hand (HP:0009802)2.11693748
95Choanal stenosis (HP:0000452)2.11596179
96Calf muscle hypertrophy (HP:0008981)2.09999794
97Hemorrhage of the eye (HP:0011885)2.08976152
98Hydroxyprolinuria (HP:0003080)2.08920553
99Abnormality of proline metabolism (HP:0010907)2.08920553
100Late onset (HP:0003584)2.06752516
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03719407
102Glomerulonephritis (HP:0000099)2.03281697
103Abnormal cartilage morphology (HP:0002763)2.02204622
104Hyperglycemia (HP:0003074)2.01310668
105Enlarged kidneys (HP:0000105)1.99451025
106Vomiting (HP:0002013)1.98693220
107Abnormality of the gallbladder (HP:0005264)1.97594037
108Abnormality of the calcaneus (HP:0008364)1.96879641
109Myoglobinuria (HP:0002913)1.96066577
110Vaginal fistula (HP:0004320)1.95028513
111Hyperinsulinemic hypoglycemia (HP:0000825)1.94855552
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.93089395
113EMG: myopathic abnormalities (HP:0003458)1.92678816
114Difficulty running (HP:0009046)1.92577650
115Recurrent gram-negative bacterial infections (HP:0005420)1.92388108
116Back pain (HP:0003418)1.92382768
117Status epilepticus (HP:0002133)1.90575856
118Muscle stiffness (HP:0003552)1.90492011
119Abnormality of the Achilles tendon (HP:0005109)1.90416167
120Hypertriglyceridemia (HP:0002155)1.89204361
121Rimmed vacuoles (HP:0003805)1.88280230
122Hyperuricemia (HP:0002149)1.87037222
123Increased purine levels (HP:0004368)1.87037222
124Renal duplication (HP:0000075)1.86210020
125Opisthotonus (HP:0002179)1.83200340
126Ulnar deviation of the wrist (HP:0003049)1.83094748
127Rickets (HP:0002748)1.81744677
128Turricephaly (HP:0000262)1.80323629
129Renovascular hypertension (HP:0100817)1.80217894
130Pancreatic islet-cell hyperplasia (HP:0004510)1.77875412
131Partial duplication of thumb phalanx (HP:0009944)1.77771309
132Broad alveolar ridges (HP:0000187)1.77204823
133Hypophosphatemic rickets (HP:0004912)1.76474626
134Abnormality of transition element cation homeostasis (HP:0011030)1.76318894
135Thrombophlebitis (HP:0004418)1.75762623
136Generalized aminoaciduria (HP:0002909)1.75116031
137Coronal craniosynostosis (HP:0004440)1.75039815
138Menorrhagia (HP:0000132)1.74541379
139Hyperacusis (HP:0010780)1.73065926
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71227357
141Ulnar bowing (HP:0003031)1.71093140
142Poikilocytosis (HP:0004447)1.70927702
143Neck muscle weakness (HP:0000467)1.69519096
144Gingival bleeding (HP:0000225)1.69492891
145Abnormality of carpal bone ossification (HP:0006257)1.68676302
146Abnormality of skeletal muscle fiber size (HP:0012084)1.67486752
147Abnormality of the left ventricular outflow tract (HP:0011103)1.65142042
148Subaortic stenosis (HP:0001682)1.65142042
149Hyporeflexia of lower limbs (HP:0002600)1.64494816
150Malignant hyperthermia (HP:0002047)1.61954474
151Shallow orbits (HP:0000586)1.59629325
152Neonatal short-limb short stature (HP:0008921)1.58116263
153Adducted thumb (HP:0001181)1.55196646
154Transposition of the great arteries (HP:0001669)1.53221962
155Abnormal connection of the cardiac segments (HP:0011545)1.53221962
156Abnormal ventriculo-arterial connection (HP:0011563)1.53221962
157Abnormality of the calf musculature (HP:0001430)1.52908516
158Protrusio acetabuli (HP:0003179)1.52726738
159Alacrima (HP:0000522)1.51564508
160Achilles tendon contracture (HP:0001771)1.50487631
161Myotonia (HP:0002486)1.50229627
162Stridor (HP:0010307)1.50083125
163Increased variability in muscle fiber diameter (HP:0003557)1.49774140
164Trigonocephaly (HP:0000243)1.49583485
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49552655
166Absent epiphyses (HP:0010577)1.49552655
167Increased nuchal translucency (HP:0010880)1.47447826
168Abnormality of pain sensation (HP:0010832)1.46625576
169Impaired pain sensation (HP:0007328)1.46625576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.67980356
2SIK14.75379371
3ERN13.95026290
4FGFR43.28078268
5TRIB32.89038859
6ERBB42.73709322
7LATS12.69584348
8INSRR2.56940072
9MAP2K42.30539244
10PKN22.21652870
11TAOK32.19240365
12CDK122.01410293
13FRK1.96701504
14MST1R1.91136060
15WNK41.87955439
16CAMK1D1.75489407
17SMG11.75331479
18MARK11.68485265
19FGFR21.68103643
20MAPK111.63818076
21PIK3CG1.63309948
22PTK61.61763474
23PRKD31.51204720
24MAP3K91.49987795
25PINK11.45260398
26STK38L1.43219719
27DAPK21.36553051
28PRKAA21.31938713
29MAP3K71.28778560
30NTRK21.24714899
31CAMK1G1.22015322
32PDK41.21187984
33PDK31.21187984
34NEK11.19892648
35LATS21.15575956
36MET1.15278687
37FLT31.14384477
38EPHA21.13752335
39NTRK31.12022844
40NEK91.11228893
41ICK1.07533291
42AKT31.05161785
43PDGFRA1.04791199
44RIPK11.03007752
45PHKG11.02392139
46PHKG21.02392139
47CDK61.01274794
48JAK21.01142459
49ERBB21.00882776
50ABL20.96327041
51PRKAA10.91498633
52PDK20.81576019
53PIK3CA0.81051854
54MAPK120.79825366
55ARAF0.79334215
56MAP2K30.78402589
57CDC70.78147743
58TTN0.77298197
59FER0.76512741
60CSNK1E0.76347344
61PRKCZ0.75689655
62CAMK2G0.71602178
63JAK10.70631496
64RET0.70178810
65OBSCN0.69670433
66WNK10.69123704
67GSK3A0.67388993
68RPS6KB10.66848634
69MTOR0.66818048
70TYK20.66775254
71EEF2K0.66377512
72EPHB10.65658161
73MARK20.65275571
74CDK70.65153810
75KSR20.63812834
76PRKACG0.62993039
77EPHA40.62696947
78BMX0.62600097
79NME10.62509999
80PDPK10.62398997
81SGK30.62351739
82STK380.61199148
83MAPK100.60649762
84FGFR30.60214389
85PNCK0.60005005
86MAP3K30.59749092
87MAP2K10.59557238
88DYRK20.58468196
89SGK10.57348866
90PTK20.57252982
91CASK0.56799271
92BRSK10.55957184
93RPS6KB20.54680830
94UHMK10.54634565
95TTK0.54381548
96DMPK0.52718646
97LMTK20.51552327
98CAMK10.51548284
99MAP3K100.50570049
100CAMK2B0.49477154
101RPS6KA30.49356118
102MAPK40.49318036
103CSNK1G10.49191861
104NEK20.48296941
105MAP3K20.47920755
106CDK11A0.47817545
107CDK150.46716738
108GSK3B0.46683639
109STK390.46488343
110DYRK1B0.46059215
111MAPKAPK30.45295853
112PKN10.44860209
113CDK10.44043604
114CAMK40.43924313
115RPS6KA10.43536638
116MAP3K40.43470537
117PAK30.42783315
118CAMK2D0.41969589
119ALK0.41576941
120SIK20.41487049
121TYRO30.40474616
122CDK180.40019265
123CDK50.39563860
124CDK20.39343001
125MAP3K110.39303501
126MAPK70.39207707
127PRKDC0.38980215
128DDR20.38951504
129IGF1R0.38896508
130PAK20.38735714
131FGFR10.38154595
132BRAF0.38100647
133PDK10.37796207
134CSNK1G20.37544561
135SGK20.35600615
136MAP2K60.35576054
137MAPK140.35559173
138CSNK1D0.35510519
139SGK2230.35260713
140SGK4940.35260713
141STK30.34176858
142EPHA30.33866142
143MAP3K60.33594285
144CSK0.32445692
145TAOK20.30588591
146NTRK10.30448835
147MAP3K50.29177716
148PRKCG0.28479892
149AKT20.27677104

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34005280
2Nitrogen metabolism_Homo sapiens_hsa009103.92912836
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40582141
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15353654
5* Arginine biosynthesis_Homo sapiens_hsa002202.96485305
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68060527
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66358405
8Fatty acid degradation_Homo sapiens_hsa000712.59919200
9Tryptophan metabolism_Homo sapiens_hsa003802.59640287
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58970037
11Complement and coagulation cascades_Homo sapiens_hsa046102.55341659
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55204695
13Propanoate metabolism_Homo sapiens_hsa006402.26167694
14Butanoate metabolism_Homo sapiens_hsa006502.16197703
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10389206
16PPAR signaling pathway_Homo sapiens_hsa033202.07922748
17Peroxisome_Homo sapiens_hsa041462.03206197
18Fatty acid metabolism_Homo sapiens_hsa012122.00504623
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95885047
20beta-Alanine metabolism_Homo sapiens_hsa004101.76128381
21Chemical carcinogenesis_Homo sapiens_hsa052041.75571957
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73966480
23Caffeine metabolism_Homo sapiens_hsa002321.73714040
24* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73481788
25Histidine metabolism_Homo sapiens_hsa003401.70389979
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.70352462
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63350491
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.54569285
29* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54202786
30Retinol metabolism_Homo sapiens_hsa008301.53256890
31Phenylalanine metabolism_Homo sapiens_hsa003601.53004789
32Pyruvate metabolism_Homo sapiens_hsa006201.52950644
33Staphylococcus aureus infection_Homo sapiens_hsa051501.51145263
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50833787
35Bile secretion_Homo sapiens_hsa049761.47673669
36Selenocompound metabolism_Homo sapiens_hsa004501.46968729
37Tyrosine metabolism_Homo sapiens_hsa003501.37895721
38Sulfur metabolism_Homo sapiens_hsa009201.37563164
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32942104
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32249866
41Starch and sucrose metabolism_Homo sapiens_hsa005001.30406270
42* Biosynthesis of amino acids_Homo sapiens_hsa012301.27453337
43Fatty acid elongation_Homo sapiens_hsa000621.25538410
44Fat digestion and absorption_Homo sapiens_hsa049751.24880822
45* Carbon metabolism_Homo sapiens_hsa012001.21986716
46ABC transporters_Homo sapiens_hsa020101.13880045
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08616465
48Vitamin B6 metabolism_Homo sapiens_hsa007501.07776894
49Steroid biosynthesis_Homo sapiens_hsa001001.02703278
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02628689
51Fatty acid biosynthesis_Homo sapiens_hsa000611.02330332
52Arginine and proline metabolism_Homo sapiens_hsa003301.02045791
53Folate biosynthesis_Homo sapiens_hsa007901.01274044
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.93744325
55Sulfur relay system_Homo sapiens_hsa041220.88833991
56Lysine degradation_Homo sapiens_hsa003100.88090062
57Glycerolipid metabolism_Homo sapiens_hsa005610.87598787
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.80355940
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77158417
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76883125
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76211350
62Vitamin digestion and absorption_Homo sapiens_hsa049770.75489653
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71376991
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71227420
65One carbon pool by folate_Homo sapiens_hsa006700.68654226
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68493849
67Basal cell carcinoma_Homo sapiens_hsa052170.62561418
68Dilated cardiomyopathy_Homo sapiens_hsa054140.57589344
69Glutathione metabolism_Homo sapiens_hsa004800.56821449
70Pentose phosphate pathway_Homo sapiens_hsa000300.55096106
71Cardiac muscle contraction_Homo sapiens_hsa042600.54509607
72Hippo signaling pathway_Homo sapiens_hsa043900.53481303
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51958476
74Tight junction_Homo sapiens_hsa045300.45418263
75Wnt signaling pathway_Homo sapiens_hsa043100.44243379
76* Metabolic pathways_Homo sapiens_hsa011000.42010008
77Prion diseases_Homo sapiens_hsa050200.41750158
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.41228049
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40857326
80Insulin resistance_Homo sapiens_hsa049310.39351335
81Axon guidance_Homo sapiens_hsa043600.35709829
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35393914
83Long-term potentiation_Homo sapiens_hsa047200.35110401
84Fructose and mannose metabolism_Homo sapiens_hsa000510.34618417
85Notch signaling pathway_Homo sapiens_hsa043300.33913724
86Adherens junction_Homo sapiens_hsa045200.32465290
87ECM-receptor interaction_Homo sapiens_hsa045120.31963049
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31428892
89mRNA surveillance pathway_Homo sapiens_hsa030150.30181540
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29774288
91AMPK signaling pathway_Homo sapiens_hsa041520.28276544
92Glucagon signaling pathway_Homo sapiens_hsa049220.27465711
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27302573
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25572935
95Galactose metabolism_Homo sapiens_hsa000520.22779105
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.22200228
97Melanogenesis_Homo sapiens_hsa049160.21556590
98Linoleic acid metabolism_Homo sapiens_hsa005910.20827941
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19055427
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17420264
101Insulin signaling pathway_Homo sapiens_hsa049100.11454829
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06261587
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2143695
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.2143415
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2099003
106Circadian rhythm_Homo sapiens_hsa04710-0.2012577
107Hepatitis C_Homo sapiens_hsa05160-0.1933724
108Protein digestion and absorption_Homo sapiens_hsa04974-0.1803334
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.1695925
110Renin-angiotensin system_Homo sapiens_hsa04614-0.1623786
111Amoebiasis_Homo sapiens_hsa05146-0.1551694
112Bladder cancer_Homo sapiens_hsa05219-0.1372350
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1159624
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1069773
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0962019
116Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0902645
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0809530
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0709933
119Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0548126
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0267848
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0089216

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