GPX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants and multiple pseudogenes of this gene have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.79625619
2protoporphyrinogen IX metabolic process (GO:0046501)4.41337589
3protoporphyrinogen IX biosynthetic process (GO:0006782)4.32945525
4negative regulation of interleukin-12 production (GO:0032695)4.10576042
5regulation of mast cell degranulation (GO:0043304)4.05000289
6positive regulation by symbiont of host defense response (GO:0052509)3.90270770
7modulation by symbiont of host defense response (GO:0052031)3.90270770
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.90270770
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.90270770
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.90270770
11modulation by symbiont of host immune response (GO:0052553)3.90270770
12killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.87002244
13disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.87002244
14positive regulation of mast cell activation (GO:0033005)3.85393947
15pinocytosis (GO:0006907)3.83468572
16ribosomal small subunit assembly (GO:0000028)3.83207389
17amino sugar catabolic process (GO:0046348)3.82595629
18heme biosynthetic process (GO:0006783)3.81088430
19negative regulation of erythrocyte differentiation (GO:0045647)3.80077406
20barbed-end actin filament capping (GO:0051016)3.72272887
21positive regulation of mast cell activation involved in immune response (GO:0033008)3.71364860
22positive regulation of mast cell degranulation (GO:0043306)3.71364860
23glycosphingolipid catabolic process (GO:0046479)3.67366232
24regulation of mast cell activation involved in immune response (GO:0033006)3.65625359
25heme metabolic process (GO:0042168)3.65371752
26cellular response to thyroid hormone stimulus (GO:0097067)3.64910560
27indole-containing compound catabolic process (GO:0042436)3.59751081
28indolalkylamine catabolic process (GO:0046218)3.59751081
29tryptophan catabolic process (GO:0006569)3.59751081
30regulation of leukocyte degranulation (GO:0043300)3.58221587
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57893928
32regulation of myeloid leukocyte mediated immunity (GO:0002886)3.57066824
33aromatic amino acid family catabolic process (GO:0009074)3.45631445
34macrophage activation involved in immune response (GO:0002281)3.41893520
35regulation of superoxide anion generation (GO:0032928)3.39922667
36glyoxylate metabolic process (GO:0046487)3.37262531
37adenosine receptor signaling pathway (GO:0001973)3.35701268
38tryptophan metabolic process (GO:0006568)3.34547230
39aldehyde catabolic process (GO:0046185)3.29714468
40positive regulation of leukocyte degranulation (GO:0043302)3.29369015
41positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.26963260
42L-phenylalanine catabolic process (GO:0006559)3.26936680
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.26936680
44L-phenylalanine metabolic process (GO:0006558)3.26801989
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26801989
46DNA deamination (GO:0045006)3.26519788
47positive regulation of gamma-delta T cell activation (GO:0046645)3.26467612
48detection of other organism (GO:0098543)3.25531871
49glycolipid catabolic process (GO:0019377)3.25360411
50granulocyte activation (GO:0036230)3.25087165
51B cell mediated immunity (GO:0019724)3.20390686
52regulation of mast cell activation (GO:0033003)3.18047400
53kynurenine metabolic process (GO:0070189)3.15093597
54detection of bacterium (GO:0016045)3.15035192
55killing of cells of other organism (GO:0031640)3.14095005
56disruption of cells of other organism (GO:0044364)3.14095005
57neutrophil activation involved in immune response (GO:0002283)3.13178249
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12973510
59cysteine metabolic process (GO:0006534)3.12070479
60porphyrin-containing compound biosynthetic process (GO:0006779)3.11182476
61reactive oxygen species biosynthetic process (GO:1903409)3.11060210
62myeloid cell activation involved in immune response (GO:0002275)3.08771918
63neutrophil activation (GO:0042119)3.08614322
64response to thyroid hormone (GO:0097066)3.07938384
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06305137
66porphyrin-containing compound metabolic process (GO:0006778)3.04607471
67low-density lipoprotein particle remodeling (GO:0034374)3.02673538
68negative regulation of nitric oxide biosynthetic process (GO:0045019)2.99067679
69urea metabolic process (GO:0019627)2.94229662
70urea cycle (GO:0000050)2.94229662
71sulfur amino acid catabolic process (GO:0000098)2.94193441
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92756677
73negative regulation of myeloid cell apoptotic process (GO:0033033)2.92605134
74triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92441675
75NIK/NF-kappaB signaling (GO:0038061)2.90678931
76complement activation, alternative pathway (GO:0006957)2.90073736
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87763047
78negative regulation of cell killing (GO:0031342)2.87763047
79response to muramyl dipeptide (GO:0032495)2.86423987
80glycine metabolic process (GO:0006544)2.86208488
81detection of external biotic stimulus (GO:0098581)2.86184001
82respiratory burst (GO:0045730)2.85351010
83oligosaccharide catabolic process (GO:0009313)2.84313966
84telomere maintenance via semi-conservative replication (GO:0032201)2.83179931
85NAD biosynthetic process (GO:0009435)2.82294014
86N-acetylneuraminate metabolic process (GO:0006054)2.81458654
87modulation of growth of symbiont involved in interaction with host (GO:0044144)2.80709590
88regulation of growth of symbiont in host (GO:0044126)2.80709590
89negative regulation of growth of symbiont in host (GO:0044130)2.80709590
90negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.80709590
91bile acid biosynthetic process (GO:0006699)2.80103116
92ceramide catabolic process (GO:0046514)2.79591382
93serine family amino acid biosynthetic process (GO:0009070)2.79382996
94cellular response to arsenic-containing substance (GO:0071243)2.79309347
95positive regulation of antigen processing and presentation (GO:0002579)2.79270041
96regulation of mononuclear cell migration (GO:0071675)2.78349772
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.77760430
98positive regulation of monocyte chemotaxis (GO:0090026)2.77713968
99amino-acid betaine metabolic process (GO:0006577)2.77707610
100peptidyl-glutamic acid carboxylation (GO:0017187)2.77270900
101protein carboxylation (GO:0018214)2.77270900
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77151635
103response to host immune response (GO:0052572)2.77151635
104valine metabolic process (GO:0006573)2.76553530
105mature B cell differentiation involved in immune response (GO:0002313)2.75602545
106nitrogen cycle metabolic process (GO:0071941)2.75470708
107nicotinamide nucleotide biosynthetic process (GO:0019359)2.74704970
108pyridine nucleotide biosynthetic process (GO:0019363)2.74704970
109tetrapyrrole biosynthetic process (GO:0033014)2.74259214
110G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.74025184
111lysine catabolic process (GO:0006554)2.73985693
112lysine metabolic process (GO:0006553)2.73985693
113negative regulation of phagocytosis (GO:0050765)2.73297126
114DNA strand elongation involved in DNA replication (GO:0006271)2.72701065
115phagosome maturation (GO:0090382)2.71430224
116detection of molecule of bacterial origin (GO:0032490)2.70836493
117regulation of platelet activation (GO:0010543)2.69776273
118urate metabolic process (GO:0046415)2.69217097
119positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.69087772
120regulation of regulated secretory pathway (GO:1903305)2.69043070
121modulation by symbiont of host cellular process (GO:0044068)2.68365895
122serine family amino acid metabolic process (GO:0009069)2.67238639
123macrophage differentiation (GO:0030225)2.65581134
124regulation of antigen processing and presentation (GO:0002577)2.65384117
125plasma lipoprotein particle remodeling (GO:0034369)2.63285187
126protein-lipid complex remodeling (GO:0034368)2.63285187
127macromolecular complex remodeling (GO:0034367)2.63285187
128cellular extravasation (GO:0045123)2.62622977
129positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62053113
130pentose metabolic process (GO:0019321)2.61684911
131DNA strand elongation (GO:0022616)2.61642876
132protein localization to endosome (GO:0036010)2.60496299
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60307152
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60307152
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60294300
136interferon-gamma-mediated signaling pathway (GO:0060333)2.60039220
137serine family amino acid catabolic process (GO:0009071)2.59926345
138myeloid dendritic cell differentiation (GO:0043011)2.59185744
139amine catabolic process (GO:0009310)2.59130374
140cellular biogenic amine catabolic process (GO:0042402)2.59130374
141regulation of protein activation cascade (GO:2000257)2.58553782
142modulation by virus of host process (GO:0019054)2.58246922
143alpha-linolenic acid metabolic process (GO:0036109)2.58214005
144macrophage activation (GO:0042116)2.58169732
145response to interferon-beta (GO:0035456)2.58162483
146myeloid dendritic cell activation (GO:0001773)2.58116243
147immunoglobulin mediated immune response (GO:0016064)2.55830242
148detection of biotic stimulus (GO:0009595)2.55443451
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54793882
150T-helper 1 type immune response (GO:0042088)2.54734256
151negative regulation of cytokine production involved in immune response (GO:0002719)2.54638027
152phagocytosis, engulfment (GO:0006911)2.53793930
153positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.53320075
154imidazole-containing compound metabolic process (GO:0052803)2.52693901
155regulation of triglyceride catabolic process (GO:0010896)2.52690321
156Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52653861
157cyclooxygenase pathway (GO:0019371)2.52477985
158high-density lipoprotein particle remodeling (GO:0034375)2.52227735
159regulation of cholesterol esterification (GO:0010872)2.51683723
160low-density lipoprotein particle clearance (GO:0034383)2.51287200
161negative regulation of granulocyte differentiation (GO:0030853)2.50970232
162telomere maintenance via recombination (GO:0000722)2.50926164
163response to host (GO:0075136)2.49911152
164response to host defenses (GO:0052200)2.49911152
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49911152
166antigen processing and presentation of endogenous antigen (GO:0019883)2.49883085
167production of molecular mediator involved in inflammatory response (GO:0002532)2.49501842
168purine deoxyribonucleotide catabolic process (GO:0009155)2.49351724
169positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.49033892
170response to fungus (GO:0009620)2.48682565
171regulation of macrophage chemotaxis (GO:0010758)2.47929530
172aromatic amino acid family metabolic process (GO:0009072)2.47928094
173regulation of cholesterol storage (GO:0010885)2.47484927
174regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.46918280
175regulation of hypersensitivity (GO:0002883)2.46849799
176regulation of interferon-beta biosynthetic process (GO:0045357)2.46680138
177cofactor catabolic process (GO:0051187)2.46678319
178pyrimidine-containing compound salvage (GO:0008655)2.46507477
179pyrimidine nucleoside salvage (GO:0043097)2.46507477
180negative regulation of fibrinolysis (GO:0051918)2.45967516
181regulation of complement activation (GO:0030449)2.45855079
182drug transmembrane transport (GO:0006855)2.43250776
183hydrogen peroxide biosynthetic process (GO:0050665)2.43187044
184very-low-density lipoprotein particle assembly (GO:0034379)2.42837320
185drug transport (GO:0015893)2.42021621
186carnitine metabolic process (GO:0009437)2.41738489
187phospholipid efflux (GO:0033700)2.41285493
188indolalkylamine metabolic process (GO:0006586)2.41052908
189positive regulation of B cell differentiation (GO:0045579)2.40186903
190neutrophil mediated immunity (GO:0002446)2.39610234
191plasma lipoprotein particle assembly (GO:0034377)2.39031316
192cellular response to zinc ion (GO:0071294)2.38006780
193homocysteine metabolic process (GO:0050667)2.37767548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.49120634
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.34318001
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48591297
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.11083684
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.93484991
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.81125385
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.65958814
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.65480578
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62983077
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61912766
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.35356994
12LXR_22292898_ChIP-Seq_THP-1_Human2.33597177
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.32954923
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25838299
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.24559845
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24492799
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22468757
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21497783
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21473827
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18280763
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17708317
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09290990
23GATA1_22025678_ChIP-Seq_K562_Human1.98625764
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97934642
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91743061
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91112934
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.86816322
28* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86654614
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.86591400
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.86079646
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85627042
32* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85374150
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84747427
34SCL_19346495_ChIP-Seq_HPC-7_Human1.84467009
35* LXR_22158963_ChIP-Seq_LIVER_Mouse1.83199565
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82847915
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81877862
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80799582
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80690375
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76596774
41SPI1_23127762_ChIP-Seq_K562_Human1.76478326
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74076388
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73495346
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70321975
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67432124
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67295904
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64130328
48SPI1_23547873_ChIP-Seq_NB4_Human1.63437558
49* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61406597
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.57792028
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56845743
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.56629409
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54884367
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54779026
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54149810
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.53986789
57* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53740708
58UTX_26944678_Chip-Seq_JUKART_Human1.52153493
59BCL6_27268052_Chip-Seq_Bcells_Human1.49307775
60* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48761582
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.47731588
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47173980
63* VDR_21846776_ChIP-Seq_THP-1_Human1.46726369
64VDR_23849224_ChIP-Seq_CD4+_Human1.46362730
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45480935
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44962882
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.44854359
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43037441
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42209392
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40996537
71BCOR_27268052_Chip-Seq_Bcells_Human1.40167456
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40139711
73TCF7_22412390_ChIP-Seq_EML_Mouse1.39759173
74* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39039654
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37969397
76KDM2B_26808549_Chip-Seq_DND41_Human1.37066026
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36394971
78* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36278081
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35481343
80MAF_26560356_Chip-Seq_TH2_Human1.33980920
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.33896259
82DCP1A_22483619_ChIP-Seq_HELA_Human1.33659406
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32440053
84FOXP3_21729870_ChIP-Seq_TREG_Human1.31417267
85P68_20966046_ChIP-Seq_HELA_Human1.27844660
86XRN2_22483619_ChIP-Seq_HELA_Human1.27224489
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26932196
88RACK7_27058665_Chip-Seq_MCF-7_Human1.26190336
89* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24120795
90* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23743394
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.22349762
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22219979
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20922095
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.20294892
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20290753
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19991212
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19926346
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18733758
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.18166876
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17700154
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14519905
102* TFEB_21752829_ChIP-Seq_HELA_Human1.14510128
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14279893
104AR_21909140_ChIP-Seq_LNCAP_Human1.14123073
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13669798
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.13660309
107NCOR1_26117541_ChIP-Seq_K562_Human1.13353873
108* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12457293
109CTCF_26484167_Chip-Seq_Bcells_Mouse1.11130385
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09974069
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09832322
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09574665
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09239942
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08651958
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07823942
116* VDR_24763502_ChIP-Seq_THP-1_Human1.07403373
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07303199
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06978107
119MYC_22102868_ChIP-Seq_BL_Human1.06920151
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06621208
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05699331
122GABP_19822575_ChIP-Seq_HepG2_Human1.04811649
123GATA1_19941826_ChIP-Seq_K562_Human1.04621832
124MAF_26560356_Chip-Seq_TH1_Human1.03884878
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03492641
126* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03195573
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02949730
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02858930
129SPI1_20517297_ChIP-Seq_HL60_Human1.02665567
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01735655
131CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01574449
132ELK1_19687146_ChIP-ChIP_HELA_Human1.01357189
133MYB_26560356_Chip-Seq_TH2_Human1.01157086
134IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00545443
135* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00059731
136CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00056975
137ZNF263_19887448_ChIP-Seq_K562_Human0.99692498
138MYB_26560356_Chip-Seq_TH1_Human0.98190008
139* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98001741
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97660624
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97344144
142STAT1_20625510_ChIP-Seq_HELA_Human0.97138985
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96157579
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.96010883
145* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94919961
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93660276
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91322154
148Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90990599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.02048388
2MP0005360_urolithiasis3.97412650
3MP0003806_abnormal_nucleotide_metabolis3.04053113
4MP0005085_abnormal_gallbladder_physiolo2.98817408
5MP0003656_abnormal_erythrocyte_physiolo2.96924156
6MP0001835_abnormal_antigen_presentation2.91786404
7MP0005365_abnormal_bile_salt2.90618416
8MP0003436_decreased_susceptibility_to2.67441587
9MP0008875_abnormal_xenobiotic_pharmacok2.51276592
10MP0009785_altered_susceptibility_to2.40549791
11* MP0003186_abnormal_redox_activity2.23233288
12MP0004147_increased_porphyrin_level2.22732924
13MP0004510_myositis2.17603899
14MP0002396_abnormal_hematopoietic_system2.16582876
15MP0003724_increased_susceptibility_to2.14264283
16MP0003191_abnormal_cellular_cholesterol2.13968229
17MP0009840_abnormal_foam_cell2.11889901
18MP0002148_abnormal_hypersensitivity_rea2.05877449
19MP0003300_gastrointestinal_ulcer2.04707936
20MP0009278_abnormal_bone_marrow2.03913628
21MP0005025_abnormal_response_to2.00860816
22MP0002419_abnormal_innate_immunity1.99848118
23MP0001853_heart_inflammation1.88547628
24MP0008260_abnormal_autophagy1.86211026
25MP0005397_hematopoietic_system_phenotyp1.81686138
26MP0001545_abnormal_hematopoietic_system1.81686138
27* MP0003075_altered_response_to1.81167026
28MP0010329_abnormal_lipoprotein_level1.79445108
29MP0003828_pulmonary_edema1.78696254
30MP0000604_amyloidosis1.77194894
31MP0000685_abnormal_immune_system1.75408810
32MP0001764_abnormal_homeostasis1.73607151
33MP0005083_abnormal_biliary_tract1.71143305
34* MP0005464_abnormal_platelet_physiology1.70788653
35MP0005000_abnormal_immune_tolerance1.70155559
36MP0008004_abnormal_stomach_pH1.69223996
37MP0009764_decreased_sensitivity_to1.67990479
38MP0005332_abnormal_amino_acid1.66307936
39MP0003693_abnormal_embryo_hatching1.66091754
40MP0002998_abnormal_bone_remodeling1.65806587
41MP0003252_abnormal_bile_duct1.64364600
42MP0002138_abnormal_hepatobiliary_system1.58277480
43MP0008469_abnormal_protein_level1.58074951
44MP0000609_abnormal_liver_physiology1.50119850
45MP0008057_abnormal_DNA_replication1.50034116
46MP0005671_abnormal_response_to1.49253251
47MP0002452_abnormal_antigen_presenting1.48368264
48MP0001800_abnormal_humoral_immune1.46747407
49* MP0005319_abnormal_enzyme/_coenzyme1.46713074
50MP0004019_abnormal_vitamin_homeostasis1.45697682
51MP0002723_abnormal_immune_serum1.40996064
52* MP0001845_abnormal_inflammatory_respons1.37058923
53MP0002420_abnormal_adaptive_immunity1.34734043
54MP0001819_abnormal_immune_cell1.34715909
55MP0002166_altered_tumor_susceptibility1.34709819
56MP0003195_calcinosis1.33962888
57MP0010094_abnormal_chromosome_stability1.32965906
58MP0009643_abnormal_urine_homeostasis1.32060636
59MP0009333_abnormal_splenocyte_physiolog1.31909058
60MP0001666_abnormal_nutrient_absorption1.28623445
61MP0005387_immune_system_phenotype1.28272717
62MP0001790_abnormal_immune_system1.28272717
63MP0002398_abnormal_bone_marrow1.27989464
64MP0009763_increased_sensitivity_to1.27677642
65MP0000689_abnormal_spleen_morphology1.27509512
66MP0005166_decreased_susceptibility_to1.25166600
67MP0005058_abnormal_lysosome_morphology1.24408889
68MP0005636_abnormal_mineral_homeostasis1.24287977
69MP0005167_abnormal_blood-brain_barrier1.24060249
70MP0000858_altered_metastatic_potential1.23186398
71MP0003448_altered_tumor_morphology1.22334625
72MP0004782_abnormal_surfactant_physiolog1.21967115
73MP0002405_respiratory_system_inflammati1.21435364
74MP0002006_tumorigenesis1.20933098
75MP0003453_abnormal_keratinocyte_physiol1.20087188
76MP0003111_abnormal_nucleus_morphology1.20078905
77* MP0005584_abnormal_enzyme/coenzyme_acti1.19606195
78MP0002429_abnormal_blood_cell1.17758011
79MP0002722_abnormal_immune_system1.17072802
80MP0000716_abnormal_immune_system1.16388830
81MP0000343_altered_response_to1.16053232
82MP0000598_abnormal_liver_morphology1.16019774
83MP0002132_abnormal_respiratory_system1.15450927
84* MP0010155_abnormal_intestine_physiology1.12995679
85MP0001533_abnormal_skeleton_physiology1.12678704
86MP0006082_CNS_inflammation1.11797111
87* MP0000490_abnormal_crypts_of1.09598618
88* MP0006036_abnormal_mitochondrial_physio1.04054619
89MP0003303_peritoneal_inflammation1.03191907
90MP0001851_eye_inflammation1.02778181
91MP0001542_abnormal_bone_strength1.01835423
92MP0003183_abnormal_peptide_metabolism1.01831483
93MP0003690_abnormal_glial_cell1.00878113
94MP0009697_abnormal_copulation1.00625149
95MP0003279_aneurysm1.00594237
96MP0005390_skeleton_phenotype1.00558453
97MP0006054_spinal_hemorrhage1.00416439
98* MP0003077_abnormal_cell_cycle0.99712766
99MP0002877_abnormal_melanocyte_morpholog0.97834687
100* MP0002118_abnormal_lipid_homeostasis0.97462503
101MP0004957_abnormal_blastocyst_morpholog0.96570713
102MP0008007_abnormal_cellular_replicative0.95128633
103MP0000465_gastrointestinal_hemorrhage0.94414590
104MP0000249_abnormal_blood_vessel0.94193108
105MP0002019_abnormal_tumor_incidence0.93395160
106MP0008058_abnormal_DNA_repair0.92692711
107MP0005310_abnormal_salivary_gland0.92337927
108MP0001849_ear_inflammation0.91671879
109* MP0005165_increased_susceptibility_to0.91242197
110MP0005164_abnormal_response_to0.90426473
111MP0003566_abnormal_cell_adhesion0.89514828
112MP0003172_abnormal_lysosome_physiology0.89025968
113MP0002136_abnormal_kidney_physiology0.89012871
114MP0005075_abnormal_melanosome_morpholog0.89012711
115MP0005376_homeostasis/metabolism_phenot0.87544090
116MP0003329_amyloid_beta_deposits0.84654795
117MP0005666_abnormal_adipose_tissue0.83524980
118MP0009765_abnormal_xenobiotic_induced0.83359392
119MP0005023_abnormal_wound_healing0.83330260
120MP0004808_abnormal_hematopoietic_stem0.83265684
121MP0008873_increased_physiological_sensi0.83123412
122MP0003705_abnormal_hypodermis_morpholog0.81529726
123MP0004185_abnormal_adipocyte_glucose0.81213510
124MP0010307_abnormal_tumor_latency0.80915266
125MP0008874_decreased_physiological_sensi0.79469287
126MP0003795_abnormal_bone_structure0.79046670
127MP0005174_abnormal_tail_pigmentation0.78022256
128MP0005670_abnormal_white_adipose0.76860205
129MP0004883_abnormal_blood_vessel0.76754534
130MP0004947_skin_inflammation0.76674120
131MP0003763_abnormal_thymus_physiology0.76596768
132MP0009642_abnormal_blood_homeostasis0.73912960
133MP0005408_hypopigmentation0.73561622
134* MP0001663_abnormal_digestive_system0.72994288
135MP0003011_delayed_dark_adaptation0.72035287
136MP0005451_abnormal_body_composition0.71486047
137MP0003091_abnormal_cell_migration0.68106210
138MP0000015_abnormal_ear_pigmentation0.66192780
139MP0002933_joint_inflammation0.61852739
140MP0002332_abnormal_exercise_endurance0.60991430

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.02591532
2Abnormality of liposaccharide metabolism (HP:0010968)6.02591532
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.02591532
4Increased cerebral lipofuscin (HP:0011813)4.63568145
5Dysostosis multiplex (HP:0000943)4.33197636
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.02416696
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.01227037
8Recurrent gram-negative bacterial infections (HP:0005420)3.87178812
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.70239181
10Recurrent abscess formation (HP:0002722)3.69717513
11Joint hemorrhage (HP:0005261)3.66709032
12Recurrent bacterial skin infections (HP:0005406)3.65340188
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.51255733
14Abnormality of pyrimidine metabolism (HP:0004353)3.49467420
15Loss of speech (HP:0002371)3.41859358
16Prolonged partial thromboplastin time (HP:0003645)3.40390212
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.38575521
18Thrombocytosis (HP:0001894)3.30317815
19Eczematoid dermatitis (HP:0000976)3.25339755
20Poikilocytosis (HP:0004447)3.22601806
21Intrahepatic cholestasis (HP:0001406)3.21955767
22Hepatosplenomegaly (HP:0001433)3.20835977
23Systemic lupus erythematosus (HP:0002725)3.17103104
24Amyloidosis (HP:0011034)3.09538411
25Hypobetalipoproteinemia (HP:0003563)3.07305210
26Petechiae (HP:0000967)3.05942198
27Abnormal number of erythroid precursors (HP:0012131)3.05530986
28Elevated erythrocyte sedimentation rate (HP:0003565)3.02755185
29Nausea (HP:0002018)3.01973197
30Abnormality of mucopolysaccharide metabolism (HP:0011020)3.00551267
31Abnormality of polysaccharide metabolism (HP:0011012)3.00551267
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.00551267
33Upper motor neuron abnormality (HP:0002127)3.00327317
34Deep venous thrombosis (HP:0002625)3.00286250
35Disinhibition (HP:0000734)2.93590986
36Xanthomatosis (HP:0000991)2.88941045
37Abnormality of cells of the erythroid lineage (HP:0012130)2.88636689
38Abnormal platelet volume (HP:0011876)2.81916851
39Reduced antithrombin III activity (HP:0001976)2.79922103
40Mucopolysacchariduria (HP:0008155)2.79652044
41Urinary glycosaminoglycan excretion (HP:0003541)2.79652044
42Complement deficiency (HP:0004431)2.78643038
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77665570
44Abnormality of the common coagulation pathway (HP:0010990)2.74469989
45Vertebral compression fractures (HP:0002953)2.72887136
46Hypochromic microcytic anemia (HP:0004840)2.72147819
47* Hyperbilirubinemia (HP:0002904)2.71480266
48Generalized aminoaciduria (HP:0002909)2.71224112
49Vacuolated lymphocytes (HP:0001922)2.70576200
50Abnormality of fatty-acid metabolism (HP:0004359)2.66161424
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66105475
52Mutism (HP:0002300)2.62063755
53Hyperammonemia (HP:0001987)2.60240066
54Autoimmune thrombocytopenia (HP:0001973)2.59270125
55Abnormality of complement system (HP:0005339)2.58927309
56Menorrhagia (HP:0000132)2.57574031
57Increased mean platelet volume (HP:0011877)2.56250126
58Myocardial infarction (HP:0001658)2.55316825
59Myositis (HP:0100614)2.54664792
60Acanthocytosis (HP:0001927)2.52635900
61Stomatitis (HP:0010280)2.51284171
62Epistaxis (HP:0000421)2.49338014
63Abnormality of macrophages (HP:0004311)2.48442340
64Cellulitis (HP:0100658)2.46186088
65Reticulocytopenia (HP:0001896)2.45130920
66Abnormality of nucleobase metabolism (HP:0010932)2.44068829
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43138761
68Progressive neurologic deterioration (HP:0002344)2.41437087
69Urticaria (HP:0001025)2.40297273
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.35042030
71Increased serum ferritin (HP:0003281)2.33197228
72Microcytic anemia (HP:0001935)2.32798571
73Abnormality of iron homeostasis (HP:0011031)2.31964468
74Hyperlipoproteinemia (HP:0010980)2.31787360
75Hyperglycinuria (HP:0003108)2.31774186
76Recurrent skin infections (HP:0001581)2.30993455
77Gingival bleeding (HP:0000225)2.29088001
78Abnormality of methionine metabolism (HP:0010901)2.28379223
79Abnormality of sulfur amino acid metabolism (HP:0004339)2.27751912
80Prolonged neonatal jaundice (HP:0006579)2.27505602
81Hypoglycemic coma (HP:0001325)2.26321746
82Hepatocellular carcinoma (HP:0001402)2.25857932
83IgM deficiency (HP:0002850)2.25710283
84Aplastic anemia (HP:0001915)2.24787068
85Nuclear cataract (HP:0100018)2.24205247
86Abnormality of the prostate (HP:0008775)2.23760541
87Hypochromic anemia (HP:0001931)2.21850553
88Meningitis (HP:0001287)2.21555809
89Abnormality of reticulocytes (HP:0004312)2.20981200
90Fat malabsorption (HP:0002630)2.19249833
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18121544
92Dicarboxylic aciduria (HP:0003215)2.18121544
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17940283
94Thrombophlebitis (HP:0004418)2.17800169
95Periodontitis (HP:0000704)2.17248516
96Recurrent fungal infections (HP:0002841)2.16468404
97Abnormality of the intrinsic pathway (HP:0010989)2.14435268
98Hypertensive crisis (HP:0100735)2.14245629
99Mediastinal lymphadenopathy (HP:0100721)2.13750803
100Glomerulonephritis (HP:0000099)2.12939698
101Abnormality of transition element cation homeostasis (HP:0011030)2.10946851
102Neurofibrillary tangles (HP:0002185)2.10515359
103Pustule (HP:0200039)2.09942283
104Polygenic inheritance (HP:0010982)2.09704105
105Purpura (HP:0000979)2.09267314
106Conjunctival telangiectasia (HP:0000524)2.08814184
107Reticulocytosis (HP:0001923)2.07396983
108Proximal tubulopathy (HP:0000114)2.07013685
109Thoracic kyphosis (HP:0002942)2.06418149
110Neuronal loss in central nervous system (HP:0002529)2.06167925
111Increased IgM level (HP:0003496)2.03164008
112Chronic obstructive pulmonary disease (HP:0006510)2.03041801
113Obstructive lung disease (HP:0006536)2.03041801
114Abnormality of T cell physiology (HP:0011840)2.02572086
115Hypolipoproteinemia (HP:0010981)1.99885027
116Abnormality of serine family amino acid metabolism (HP:0010894)1.99823053
117Abnormality of glycine metabolism (HP:0010895)1.99823053
118Pathologic fracture (HP:0002756)1.99234777
119Hypertriglyceridemia (HP:0002155)1.98236015
120Steatorrhea (HP:0002570)1.98203970
121Cholelithiasis (HP:0001081)1.96889116
122Spontaneous hematomas (HP:0007420)1.96577285
123Abnormal platelet function (HP:0011869)1.96391630
124Impaired platelet aggregation (HP:0003540)1.96391630
125Hepatic necrosis (HP:0002605)1.96165447
126Nonimmune hydrops fetalis (HP:0001790)1.95871893
127Abnormality of the nasal mucosa (HP:0000433)1.95582272
128Orchitis (HP:0100796)1.95333192
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93603652
130Recurrent viral infections (HP:0004429)1.93521555
131Prolonged bleeding time (HP:0003010)1.92546254
132Delayed CNS myelination (HP:0002188)1.91746031
133Personality changes (HP:0000751)1.91552161
134Abnormality of purine metabolism (HP:0004352)1.91369533
135Diminished motivation (HP:0000745)1.91103259
136Axonal loss (HP:0003447)1.89051350
137Distal lower limb muscle weakness (HP:0009053)1.88746479
138Type I transferrin isoform profile (HP:0003642)1.88510105
139Basal ganglia calcification (HP:0002135)1.87926342
140Colitis (HP:0002583)1.87848375
141Gastrointestinal inflammation (HP:0004386)1.87187960
142Inflammation of the large intestine (HP:0002037)1.86475424
143Hypercholesterolemia (HP:0003124)1.86384933
144Ketosis (HP:0001946)1.85733238
145Macrocytic anemia (HP:0001972)1.84759947
146Abnormality of urine glucose concentration (HP:0011016)1.84564433
147Glycosuria (HP:0003076)1.84564433
148Poor head control (HP:0002421)1.84435413
149Gingivitis (HP:0000230)1.83676266
150Hyperglycinemia (HP:0002154)1.83631284
151Polycythemia (HP:0001901)1.82762774
152Bone pain (HP:0002653)1.81778842
153Increased IgE level (HP:0003212)1.80940589
154Vasculitis (HP:0002633)1.80901740
155Dementia (HP:0000726)1.80344989
156Apathy (HP:0000741)1.79251614
157Cerebral inclusion bodies (HP:0100314)1.77461823
158Chronic mucocutaneous candidiasis (HP:0002728)1.77019408
159Recurrent cutaneous fungal infections (HP:0011370)1.77019408
160Optic neuritis (HP:0100653)1.74711343
161Retrobulbar optic neuritis (HP:0100654)1.74711343
162Pulmonary infiltrates (HP:0002113)1.73662680
163Abnormality of lateral ventricle (HP:0030047)1.73364933
164Achilles tendon contracture (HP:0001771)1.72729039
165Asymmetric septal hypertrophy (HP:0001670)1.71827357
166Abnormality of the Achilles tendon (HP:0005109)1.71530640
167Agnosia (HP:0010524)1.68728146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.05599394
2NME22.87221298
3PIM22.83830542
4IRAK42.63133560
5BLK2.48437852
6BCKDK2.48276384
7MAP3K142.43189034
8ARAF2.42195618
9STK162.39539117
10IRAK32.37516173
11ERN12.33473006
12PRPF4B2.07020073
13TAOK32.05079209
14MAP4K12.04085750
15MAP2K31.99985207
16TYK21.94171950
17KIT1.84116033
18FLT31.83128192
19TBK11.82567773
20TEC1.79352667
21WEE11.78082671
22BUB11.77955933
23FES1.76714768
24BTK1.73998361
25EIF2AK31.64611790
26PIM11.59030942
27PBK1.54019642
28IKBKB1.49574786
29VRK11.47626644
30FGR1.43208531
31STK41.40010869
32TAOK11.38771108
33MAP3K111.35634443
34KDR1.33815957
35BRSK21.33630166
36NEK91.32995440
37IKBKE1.32060732
38SMG11.29206634
39GRK71.27496606
40ACVR1B1.23436702
41VRK21.23161670
42JAK31.22210217
43BMX1.19305573
44CDC71.17820594
45RPS6KA41.17374621
46MOS1.17187543
47ZAP701.15421143
48ZAK1.15097601
49STK101.15062515
50TLK11.09560299
51SYK1.08943886
52CSF1R1.05305660
53MAP3K11.04130344
54DDR21.01228107
55LIMK11.00855212
56PIK3CG1.00782166
57HCK1.00689000
58SCYL21.00477909
59TNK21.00417962
60TRIB30.98744411
61EIF2AK20.97570875
62LRRK20.95437003
63BRAF0.95375635
64LYN0.94595239
65MAP3K130.93438709
66EPHB20.93361710
67TXK0.92609216
68MAP3K120.91875119
69DYRK30.91167169
70MAP3K30.89991660
71DAPK30.89396129
72TRPM70.87406128
73CDK70.85938952
74NEK10.85436258
75MAPK110.84858255
76MST1R0.84463533
77TGFBR20.84330030
78GRK60.83878556
79TESK20.83407175
80JAK20.82196972
81MAP3K80.82108218
82PKN20.81845056
83MATK0.81000517
84CDK190.80856322
85NEK20.80222324
86PAK40.79790391
87PDPK10.79004311
88CDK40.77690036
89ATR0.77641121
90CDC42BPA0.76195598
91CLK10.75363116
92* ABL20.74188896
93TGFBR10.74036454
94MAPKAPK30.72513457
95RPS6KA60.72304796
96AURKB0.71542681
97ILK0.70743889
98CDK60.69457443
99BRSK10.68860640
100CHUK0.68195811
101PRKD20.67943194
102CAMKK20.66008855
103PAK10.65548507
104RPS6KB20.65127654
105MYLK0.64573597
106RIPK40.63675084
107RPS6KC10.63116834
108RPS6KL10.63116834
109TAOK20.58977470
110PLK40.58700814
111SRPK10.58114740
112TESK10.57040625
113JAK10.56832151
114RPS6KA20.56282944
115MAPK120.55809656
116PLK10.55679639
117FGFR40.54221386
118IRAK20.53547289
119MST40.52992229
120DAPK10.52986343
121MARK30.52441896
122MAPK40.51831594
123SIK10.50166764
124TTN0.49636579
125CSK0.49259433
126PRKG20.48670778
127LCK0.48599473
128PDK10.48523753
129GRK50.48468805
130RIPK10.47983124
131PRKCD0.47278813
132EPHB10.47158086
133CSNK2A10.45683698
134MAP3K50.45095278
135ICK0.44465586
136MAP2K60.44350913
137SIK30.44291632
138BMPR20.43227973
139CAMK1D0.42659655
140TIE10.41847934
141HIPK20.40955993
142TTK0.40687636
143MAP3K60.38774221
144PTK2B0.34866062
145MARK20.34419981
146MAPKAPK20.33266634
147LMTK20.30263770

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.68396376
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.67802874
3DNA replication_Homo sapiens_hsa030302.61223496
4Asthma_Homo sapiens_hsa053102.52535747
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50593410
6Osteoclast differentiation_Homo sapiens_hsa043802.49754327
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24167055
8Rheumatoid arthritis_Homo sapiens_hsa053232.23174414
9Graft-versus-host disease_Homo sapiens_hsa053322.12406112
10Staphylococcus aureus infection_Homo sapiens_hsa051502.06159132
11Autoimmune thyroid disease_Homo sapiens_hsa053202.05503948
12Tuberculosis_Homo sapiens_hsa051522.05093270
13Complement and coagulation cascades_Homo sapiens_hsa046101.93793435
14Phagosome_Homo sapiens_hsa041451.92431154
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91634545
16Ribosome_Homo sapiens_hsa030101.88456243
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.85793355
18One carbon pool by folate_Homo sapiens_hsa006701.75778638
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75454897
20Proteasome_Homo sapiens_hsa030501.71475339
21Peroxisome_Homo sapiens_hsa041461.71434256
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70203744
23Mismatch repair_Homo sapiens_hsa034301.69732472
24Tryptophan metabolism_Homo sapiens_hsa003801.69600281
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62769326
26Fatty acid degradation_Homo sapiens_hsa000711.55825324
27Folate biosynthesis_Homo sapiens_hsa007901.55136395
28Caffeine metabolism_Homo sapiens_hsa002321.54811675
29Viral myocarditis_Homo sapiens_hsa054161.51853712
30Salmonella infection_Homo sapiens_hsa051321.51734180
31Selenocompound metabolism_Homo sapiens_hsa004501.51256427
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50651555
33Arginine biosynthesis_Homo sapiens_hsa002201.49529767
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48977572
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45342236
36Pentose phosphate pathway_Homo sapiens_hsa000301.44332647
37B cell receptor signaling pathway_Homo sapiens_hsa046621.44329241
38Type I diabetes mellitus_Homo sapiens_hsa049401.43329740
39Base excision repair_Homo sapiens_hsa034101.42443619
40Histidine metabolism_Homo sapiens_hsa003401.42331086
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40254276
42Toxoplasmosis_Homo sapiens_hsa051451.39153621
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39113080
44beta-Alanine metabolism_Homo sapiens_hsa004101.36060326
45Chemical carcinogenesis_Homo sapiens_hsa052041.35319127
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35034052
47Collecting duct acid secretion_Homo sapiens_hsa049661.32593190
48Shigellosis_Homo sapiens_hsa051311.32134766
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29748297
50Pyrimidine metabolism_Homo sapiens_hsa002401.28068235
51Platelet activation_Homo sapiens_hsa046111.25808213
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24607353
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22576985
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21387166
55Homologous recombination_Homo sapiens_hsa034401.20723871
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20267737
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.19939086
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19785457
59Sulfur relay system_Homo sapiens_hsa041221.16726471
60Nitrogen metabolism_Homo sapiens_hsa009101.16093915
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.15956318
62Leishmaniasis_Homo sapiens_hsa051401.15136550
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13419403
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09813889
65Acute myeloid leukemia_Homo sapiens_hsa052211.09235308
66Starch and sucrose metabolism_Homo sapiens_hsa005001.07971449
67* Glutathione metabolism_Homo sapiens_hsa004801.07010903
68Legionellosis_Homo sapiens_hsa051341.06357282
69Biosynthesis of amino acids_Homo sapiens_hsa012301.04659727
70Carbon metabolism_Homo sapiens_hsa012001.04369670
71Propanoate metabolism_Homo sapiens_hsa006401.03812762
72Cyanoamino acid metabolism_Homo sapiens_hsa004601.02809221
73Nucleotide excision repair_Homo sapiens_hsa034201.01230974
74Retinol metabolism_Homo sapiens_hsa008301.01229030
75PPAR signaling pathway_Homo sapiens_hsa033201.00711909
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00583528
77TNF signaling pathway_Homo sapiens_hsa046681.00439945
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99778582
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98889403
80Phenylalanine metabolism_Homo sapiens_hsa003600.97581289
81Prion diseases_Homo sapiens_hsa050200.96763858
82Primary immunodeficiency_Homo sapiens_hsa053400.95848186
83Other glycan degradation_Homo sapiens_hsa005110.95129697
84Chemokine signaling pathway_Homo sapiens_hsa040620.94795345
85Systemic lupus erythematosus_Homo sapiens_hsa053220.93721900
86Vibrio cholerae infection_Homo sapiens_hsa051100.93605782
87Bladder cancer_Homo sapiens_hsa052190.92266492
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90839679
89Vitamin B6 metabolism_Homo sapiens_hsa007500.88635892
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86248121
91RNA polymerase_Homo sapiens_hsa030200.85293693
92ABC transporters_Homo sapiens_hsa020100.82612799
93Galactose metabolism_Homo sapiens_hsa000520.80665400
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.79641476
95Pyruvate metabolism_Homo sapiens_hsa006200.78782273
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78364612
97Fatty acid metabolism_Homo sapiens_hsa012120.77416506
98Pertussis_Homo sapiens_hsa051330.76712160
99Vitamin digestion and absorption_Homo sapiens_hsa049770.75702044
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75417732
101* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75163924
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74724892
103Sulfur metabolism_Homo sapiens_hsa009200.74476191
104Amoebiasis_Homo sapiens_hsa051460.73437747
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.72853569
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72688219
107Endocytosis_Homo sapiens_hsa041440.72329910
108Tyrosine metabolism_Homo sapiens_hsa003500.71238405
109Protein export_Homo sapiens_hsa030600.71057668
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.70941168
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.70892723
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69778913
113Herpes simplex infection_Homo sapiens_hsa051680.69637807
114African trypanosomiasis_Homo sapiens_hsa051430.69359121
115Non-homologous end-joining_Homo sapiens_hsa034500.68504939
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68121108
117Butanoate metabolism_Homo sapiens_hsa006500.65907392
118Antigen processing and presentation_Homo sapiens_hsa046120.65320246
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64867951
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64012047
121Arginine and proline metabolism_Homo sapiens_hsa003300.63471682
122Measles_Homo sapiens_hsa051620.61273376
123Malaria_Homo sapiens_hsa051440.60930869
124Hepatitis C_Homo sapiens_hsa051600.58387333
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56249872
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56231256
127Epstein-Barr virus infection_Homo sapiens_hsa051690.55921843
128Metabolic pathways_Homo sapiens_hsa011000.55500773
129VEGF signaling pathway_Homo sapiens_hsa043700.55103325
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55055746
131Hepatitis B_Homo sapiens_hsa051610.54702194
132Pancreatic cancer_Homo sapiens_hsa052120.54659463
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54101045
134Spliceosome_Homo sapiens_hsa030400.53726884
135Fatty acid elongation_Homo sapiens_hsa000620.52225640
136Fructose and mannose metabolism_Homo sapiens_hsa000510.52033570
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.50255391
138p53 signaling pathway_Homo sapiens_hsa041150.49991807
139Chronic myeloid leukemia_Homo sapiens_hsa052200.49488110
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48846552
141Notch signaling pathway_Homo sapiens_hsa043300.48818158
142Lysosome_Homo sapiens_hsa041420.47758088
143Oxidative phosphorylation_Homo sapiens_hsa001900.47258608
144Allograft rejection_Homo sapiens_hsa053300.46502341
145Cell cycle_Homo sapiens_hsa041100.45873604
146Apoptosis_Homo sapiens_hsa042100.45605175
147Hematopoietic cell lineage_Homo sapiens_hsa046400.45155555
148Influenza A_Homo sapiens_hsa051640.45149918
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.44816932
150Renin-angiotensin system_Homo sapiens_hsa046140.43925962
151Fat digestion and absorption_Homo sapiens_hsa049750.43373794
152HTLV-I infection_Homo sapiens_hsa051660.42753342
153Fanconi anemia pathway_Homo sapiens_hsa034600.42573788
154Sphingolipid metabolism_Homo sapiens_hsa006000.40468043
155Viral carcinogenesis_Homo sapiens_hsa052030.37887048
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37167062
157T cell receptor signaling pathway_Homo sapiens_hsa046600.35112519
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.34318219
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32879370
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.31874653
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28905380

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