GPX1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.43463474
2neutrophil activation involved in immune response (GO:0002283)5.47945556
3immunoglobulin mediated immune response (GO:0016064)4.54125816
4adenosine metabolic process (GO:0046085)3.93111891
5B cell mediated immunity (GO:0019724)3.92871947
6platelet dense granule organization (GO:0060155)3.89842065
7purine nucleotide salvage (GO:0032261)3.89026624
8negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.88305639
9negative regulation of thymocyte apoptotic process (GO:0070244)3.76201306
10DNA deamination (GO:0045006)3.63357473
11negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.59986162
12lipoxygenase pathway (GO:0019372)3.44764707
13response to xenobiotic stimulus (GO:0009410)3.36915502
14xenobiotic catabolic process (GO:0042178)3.36647576
15skeletal muscle tissue regeneration (GO:0043403)3.36421535
16positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.15215951
17purine deoxyribonucleotide catabolic process (GO:0009155)3.06646393
18heart contraction (GO:0060047)3.05927444
19heart process (GO:0003015)3.05927444
20positive regulation of mast cell activation (GO:0033005)3.04097493
21purine-containing compound salvage (GO:0043101)3.00793038
22regulation of mast cell activation (GO:0033003)2.98522821
23response to interferon-beta (GO:0035456)2.96588174
24neutrophil activation (GO:0042119)2.91399501
25fusion of sperm to egg plasma membrane (GO:0007342)2.90492548
26regulation of platelet activation (GO:0010543)2.89268423
27positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.87657685
28amine catabolic process (GO:0009310)2.86932547
29cellular biogenic amine catabolic process (GO:0042402)2.86932547
30regulation of B cell apoptotic process (GO:0002902)2.86234839
31phosphatidylinositol acyl-chain remodeling (GO:0036149)2.86193203
32response to gravity (GO:0009629)2.85531488
33autophagic vacuole fusion (GO:0000046)2.83185317
34negative regulation of heart rate (GO:0010459)2.79263315
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78735188
36deoxyribonucleotide catabolic process (GO:0009264)2.77475677
37GMP metabolic process (GO:0046037)2.75569065
38regulation of inflammatory response to antigenic stimulus (GO:0002861)2.74316884
39positive regulation of endothelial cell differentiation (GO:0045603)2.73815740
40mitochondrial calcium ion transport (GO:0006851)2.72693145
41positive regulation of mast cell degranulation (GO:0043306)2.72635669
42positive regulation of mast cell activation involved in immune response (GO:0033008)2.72635669
43leukocyte migration involved in inflammatory response (GO:0002523)2.72243601
44granulocyte activation (GO:0036230)2.71169984
45negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.71104079
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70370856
47ATP synthesis coupled proton transport (GO:0015986)2.69575411
48energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69575411
49protein complex biogenesis (GO:0070271)2.69556232
50thrombin receptor signaling pathway (GO:0070493)2.67213549
51protein maturation by protein folding (GO:0022417)2.66631056
52deoxyribose phosphate catabolic process (GO:0046386)2.66468897
53nucleotide salvage (GO:0043173)2.66141248
54regulation of T-helper 1 cell differentiation (GO:0045625)2.65656372
55negative regulation of nitric-oxide synthase activity (GO:0051001)2.65533572
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64831361
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.64831361
58NADH dehydrogenase complex assembly (GO:0010257)2.64831361
59response to hydroperoxide (GO:0033194)2.64472414
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.61036729
61regulation of skeletal muscle contraction (GO:0014819)2.60861169
62intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.60757716
63regulation of thymocyte apoptotic process (GO:0070243)2.57415199
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55633387
65plasma membrane fusion (GO:0045026)2.55135397
66positive regulation of antigen processing and presentation (GO:0002579)2.53932431
67chaperone mediated protein folding requiring cofactor (GO:0051085)2.53375849
68sulfur amino acid catabolic process (GO:0000098)2.52755907
69response to peptidoglycan (GO:0032494)2.52252608
70regulation of mast cell activation involved in immune response (GO:0033006)2.51705660
71leukocyte degranulation (GO:0043299)2.50042590
72G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.49759000
73pyrimidine nucleoside catabolic process (GO:0046135)2.49669975
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49011277
75positive regulation of systemic arterial blood pressure (GO:0003084)2.47423033
76purinergic nucleotide receptor signaling pathway (GO:0035590)2.45520988
77positive regulation of protein homodimerization activity (GO:0090073)2.44080016
78cullin deneddylation (GO:0010388)2.42960885
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.42108051
80myeloid cell activation involved in immune response (GO:0002275)2.41312972
81negative regulation of calcium ion transport into cytosol (GO:0010523)2.40764130
82sequestering of actin monomers (GO:0042989)2.39290531
83mitochondrial calcium ion homeostasis (GO:0051560)2.38700877
84negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37385483
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37289503
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37289503
87interferon-gamma-mediated signaling pathway (GO:0060333)2.36711272
88positive regulation of prostaglandin secretion (GO:0032308)2.36513186
89regulation of mast cell degranulation (GO:0043304)2.36471771
90protein deneddylation (GO:0000338)2.36053052
91negative regulation of mast cell activation (GO:0033004)2.35549051
92phagosome maturation (GO:0090382)2.35213590
93respiratory chain complex IV assembly (GO:0008535)2.33752704
94cytochrome complex assembly (GO:0017004)2.33658128
95angiogenesis involved in wound healing (GO:0060055)2.33444072
96mature B cell differentiation involved in immune response (GO:0002313)2.33266459
97L-phenylalanine catabolic process (GO:0006559)2.33202433
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.33202433
99mitochondrial respiratory chain complex assembly (GO:0033108)2.32351126
100regulation of germinal center formation (GO:0002634)2.31216925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.65328275
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.69197122
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54623151
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.44491122
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12233814
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.05312213
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.93092928
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.87942327
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71592608
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71526990
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.69301969
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67006016
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.47633048
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42020562
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34418523
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31636044
17SPI1_23547873_ChIP-Seq_NB4_Human2.30212797
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23837428
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23591533
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.16211110
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.14277446
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07006263
23LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99134740
24MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88695082
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87730553
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87673508
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.87063532
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84068962
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83095424
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76860389
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71979325
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.69322018
33VDR_23849224_ChIP-Seq_CD4+_Human1.65384276
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63651136
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62060761
36SPI1_23127762_ChIP-Seq_K562_Human1.59757093
37STAT1_20625510_ChIP-Seq_HELA_Human1.59352436
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58225834
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.56658719
40VDR_22108803_ChIP-Seq_LS180_Human1.49926563
41FOXP3_21729870_ChIP-Seq_TREG_Human1.49242428
42SCL_19346495_ChIP-Seq_HPC-7_Human1.43614577
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35448083
44FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35207357
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33508106
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32967872
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31423303
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31415782
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30894012
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.29469420
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29455258
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28000899
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26767907
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26117295
55VDR_24763502_ChIP-Seq_THP-1_Human1.26043780
56GATA3_26560356_Chip-Seq_TH2_Human1.25216760
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23776507
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23631682
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.23487249
60MYB_26560356_Chip-Seq_TH2_Human1.22866214
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21209609
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19671987
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17796126
64MYC_18940864_ChIP-ChIP_HL60_Human1.15669604
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11321546
66AR_20517297_ChIP-Seq_VCAP_Human1.10536245
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.09549240
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08157625
69SPI1_20517297_ChIP-Seq_HL60_Human1.07255433
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06541520
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06348025
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06031216
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02478867
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01868738
75P300_27268052_Chip-Seq_Bcells_Human1.01469494
76TAF2_19829295_ChIP-Seq_ESCs_Human1.00847573
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00678075
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00676414
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00506404
80BCL6_27268052_Chip-Seq_Bcells_Human0.99988914
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99985742
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99947448
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99333249
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99054426
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98695339
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98489997
87ELK1_19687146_ChIP-ChIP_HELA_Human0.96996490
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96664040
89CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95994107
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95766588
91ERG_20517297_ChIP-Seq_VCAP_Human0.94127984
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92320831
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91485439
94MYB_26560356_Chip-Seq_TH1_Human0.90788668
95TFEB_21752829_ChIP-Seq_HELA_Human0.90275277
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88929435
97NANOG_20526341_ChIP-Seq_ESCs_Human0.87908418
98CEBPB_22108803_ChIP-Seq_LS180_Human0.87862350
99UTX_26944678_Chip-Seq_JUKART_Human0.87813912
100GATA3_27048872_Chip-Seq_THYMUS_Human0.86874456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.66713104
2MP0003724_increased_susceptibility_to3.69598789
3MP0003806_abnormal_nucleotide_metabolis3.69594719
4MP0001835_abnormal_antigen_presentation3.55666971
5MP0002138_abnormal_hepatobiliary_system3.17731004
6MP0002148_abnormal_hypersensitivity_rea3.02922912
7MP0005058_abnormal_lysosome_morphology2.59373529
8MP0003303_peritoneal_inflammation2.46016634
9MP0005000_abnormal_immune_tolerance2.15585434
10MP0009785_altered_susceptibility_to2.08731127
11MP0005084_abnormal_gallbladder_morpholo2.04577210
12MP0005671_abnormal_response_to2.01618366
13MP0003186_abnormal_redox_activity2.00270663
14MP0002419_abnormal_innate_immunity1.98929755
15MP0003075_altered_response_to1.98529062
16MP0000343_altered_response_to1.98126309
17MP0008004_abnormal_stomach_pH1.94758861
18MP0002139_abnormal_hepatobiliary_system1.91614078
19MP0003436_decreased_susceptibility_to1.91176982
20MP0008875_abnormal_xenobiotic_pharmacok1.91030817
21MP0006292_abnormal_olfactory_placode1.86844144
22MP0009764_decreased_sensitivity_to1.83730446
23MP0002452_abnormal_antigen_presenting1.82665741
24MP0002723_abnormal_immune_serum1.81099070
25MP0001800_abnormal_humoral_immune1.78659098
26MP0005257_abnormal_intraocular_pressure1.74584268
27MP0006036_abnormal_mitochondrial_physio1.72093046
28MP0005410_abnormal_fertilization1.65454181
29MP0005025_abnormal_response_to1.65128235
30MP0000685_abnormal_immune_system1.58289111
31MP0001764_abnormal_homeostasis1.57836075
32MP0002420_abnormal_adaptive_immunity1.57199291
33MP0001819_abnormal_immune_cell1.55310498
34MP0005360_urolithiasis1.54114299
35MP0001533_abnormal_skeleton_physiology1.51319738
36MP0005387_immune_system_phenotype1.48793416
37MP0001790_abnormal_immune_system1.48793416
38MP0001545_abnormal_hematopoietic_system1.47391014
39MP0005397_hematopoietic_system_phenotyp1.47391014
40MP0010155_abnormal_intestine_physiology1.46247873
41MP0005646_abnormal_pituitary_gland1.43732928
42MP0001845_abnormal_inflammatory_respons1.42616358
43MP0005165_increased_susceptibility_to1.41865505
44MP0006082_CNS_inflammation1.31036270
45MP0000465_gastrointestinal_hemorrhage1.30843978
46MP0002736_abnormal_nociception_after1.29974336
47MP0008469_abnormal_protein_level1.29319194
48MP0002398_abnormal_bone_marrow1.26298167
49MP0005083_abnormal_biliary_tract1.25635364
50MP0003638_abnormal_response/metabolism_1.25157528
51MP0008789_abnormal_olfactory_epithelium1.24690560
52MP0003828_pulmonary_edema1.22570160
53MP0000858_altered_metastatic_potential1.21793239
54MP0000689_abnormal_spleen_morphology1.18607990
55MP0000716_abnormal_immune_system1.17161264
56MP0005166_decreased_susceptibility_to1.10531109
57MP0002837_dystrophic_cardiac_calcinosis1.08793275
58MP0002638_abnormal_pupillary_reflex1.08691322
59MP0002429_abnormal_blood_cell1.08459005
60MP0001663_abnormal_digestive_system1.07761757
61MP0006054_spinal_hemorrhage1.07593557
62MP0008260_abnormal_autophagy1.07217162
63MP0000230_abnormal_systemic_arterial1.04932917
64MP0005167_abnormal_blood-brain_barrier1.03916488
65MP0009333_abnormal_splenocyte_physiolog1.03293940
66MP0001542_abnormal_bone_strength1.01452872
67MP0002102_abnormal_ear_morphology1.00911200
68MP0008872_abnormal_physiological_respon1.00135713
69MP0009763_increased_sensitivity_to0.98633410
70MP0003183_abnormal_peptide_metabolism0.98495187
71MP0009697_abnormal_copulation0.97646179
72MP0002132_abnormal_respiratory_system0.96541344
73MP0002722_abnormal_immune_system0.95920073
74MP0003011_delayed_dark_adaptation0.95913321
75MP0006276_abnormal_autonomic_nervous0.94966789
76MP0009278_abnormal_bone_marrow0.93461944
77MP0000372_irregular_coat_pigmentation0.92707413
78MP0005319_abnormal_enzyme/_coenzyme0.92318150
79MP0005085_abnormal_gallbladder_physiolo0.90915024
80MP0006035_abnormal_mitochondrial_morpho0.88925841
81MP0005332_abnormal_amino_acid0.88437334
82MP0003866_abnormal_defecation0.87751454
83MP0005365_abnormal_bile_salt0.86856291
84MP0001905_abnormal_dopamine_level0.84699048
85MP0002405_respiratory_system_inflammati0.84627603
86MP0004147_increased_porphyrin_level0.84026606
87MP0001968_abnormal_touch/_nociception0.83098876
88MP0000358_abnormal_cell_content/0.82214115
89MP0004808_abnormal_hematopoietic_stem0.81695716
90MP0009643_abnormal_urine_homeostasis0.81500529
91MP0002332_abnormal_exercise_endurance0.79776281
92MP0004510_myositis0.79231952
93MP0000490_abnormal_crypts_of0.79157921
94MP0000249_abnormal_blood_vessel0.78876883
95MP0001756_abnormal_urination0.77481772
96MP0003252_abnormal_bile_duct0.76273802
97MP0002733_abnormal_thermal_nociception0.75876568
98MP0005535_abnormal_body_temperature0.75306689
99MP0005584_abnormal_enzyme/coenzyme_acti0.74270953
100MP0009053_abnormal_anal_canal0.72908809

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)4.99935627
2Dyschromatopsia (HP:0007641)4.60498637
3Prolonged bleeding time (HP:0003010)4.24428734
4Generalized aminoaciduria (HP:0002909)4.06867653
5Purpura (HP:0000979)3.88387276
6Epistaxis (HP:0000421)3.61483894
7Elevated erythrocyte sedimentation rate (HP:0003565)3.30224393
83-Methylglutaconic aciduria (HP:0003535)3.29360528
9Hyperlipoproteinemia (HP:0010980)3.23839740
10Menorrhagia (HP:0000132)3.14139516
11Acute necrotizing encephalopathy (HP:0006965)3.11894632
12Decreased central vision (HP:0007663)3.10762068
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07947823
14Abnormality of alanine metabolism (HP:0010916)3.07947823
15Hyperalaninemia (HP:0003348)3.07947823
16Abnormality of the prostate (HP:0008775)3.03166977
17Abnormality of macrophages (HP:0004311)3.01618758
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.00543938
19Hypoplasia of the fovea (HP:0007750)3.00543938
20Type 2 muscle fiber atrophy (HP:0003554)2.96780293
21Mitochondrial inheritance (HP:0001427)2.91177624
22Abnormality of glycolipid metabolism (HP:0010969)2.85090546
23Abnormality of liposaccharide metabolism (HP:0010968)2.85090546
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.85090546
25Decreased electroretinogram (ERG) amplitude (HP:0000654)2.81527102
26Recurrent bacterial skin infections (HP:0005406)2.79485129
27Recurrent abscess formation (HP:0002722)2.77895500
28Abnormal mitochondria in muscle tissue (HP:0008316)2.77007588
29Hepatic necrosis (HP:0002605)2.74308234
30Muscle fiber atrophy (HP:0100295)2.73779709
31Vacuolated lymphocytes (HP:0001922)2.72225719
32Chronic obstructive pulmonary disease (HP:0006510)2.71767393
33Obstructive lung disease (HP:0006536)2.71767393
34Nausea (HP:0002018)2.70515628
35Hepatosplenomegaly (HP:0001433)2.69567464
36Stomatitis (HP:0010280)2.69567221
37Abnormality of lateral ventricle (HP:0030047)2.67398931
38Renal Fanconi syndrome (HP:0001994)2.65933841
39Abnormality of the fovea (HP:0000493)2.63912196
40Progressive macrocephaly (HP:0004481)2.61434337
41Acute encephalopathy (HP:0006846)2.59081308
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.58019723
43Increased CSF lactate (HP:0002490)2.51570649
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49881951
45Conjunctival telangiectasia (HP:0000524)2.47492691
46Hepatocellular necrosis (HP:0001404)2.44642516
47Paralysis (HP:0003470)2.39086400
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37160155
49Increased mean platelet volume (HP:0011877)2.32029645
50Exertional dyspnea (HP:0002875)2.29761707
51Abnormal platelet volume (HP:0011876)2.29374236
52Abnormal platelet function (HP:0011869)2.28172432
53Impaired platelet aggregation (HP:0003540)2.28172432
54Cerebral edema (HP:0002181)2.24100893
55Constricted visual fields (HP:0001133)2.18549575
56Gingival bleeding (HP:0000225)2.16187535
57Myositis (HP:0100614)2.13260065
58Spontaneous hematomas (HP:0007420)2.13230161
59Abnormal drinking behavior (HP:0030082)2.10811706
60Polydipsia (HP:0001959)2.10811706
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08405922
62Dysostosis multiplex (HP:0000943)2.07690965
63Pulmonary embolism (HP:0002204)2.07486700
64Lactic acidosis (HP:0003128)2.05097673
65Abnormality of magnesium homeostasis (HP:0004921)2.04991517
66Attenuation of retinal blood vessels (HP:0007843)2.04229326
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.03574212
68Abnormal pupillary function (HP:0007686)2.03453634
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02654636
70Increased IgM level (HP:0003496)2.02207047
71Abolished electroretinogram (ERG) (HP:0000550)2.01349393
72Increased serum ferritin (HP:0003281)1.97549467
73Ketoacidosis (HP:0001993)1.96628963
74Progressive neurologic deterioration (HP:0002344)1.96191899
75Increased serum lactate (HP:0002151)1.96133536
76Polyuria (HP:0000103)1.93841129
77Encephalitis (HP:0002383)1.93156133
78Anorexia (HP:0002039)1.92965484
79Abnormality of iron homeostasis (HP:0011031)1.91572817
80Prostate neoplasm (HP:0100787)1.89683199
81Urticaria (HP:0001025)1.89221376
82Glycosuria (HP:0003076)1.88440079
83Abnormality of urine glucose concentration (HP:0011016)1.88440079
84Amyloidosis (HP:0011034)1.87863847
85Meningitis (HP:0001287)1.84639496
86Pulmonary fibrosis (HP:0002206)1.82762689
87Tongue fasciculations (HP:0001308)1.80805966
88Hypomagnesemia (HP:0002917)1.79176168
89Autoimmune thrombocytopenia (HP:0001973)1.77822452
90Palpebral edema (HP:0100540)1.77787943
91Type I transferrin isoform profile (HP:0003642)1.77648973
92Basal ganglia calcification (HP:0002135)1.77284306
93Hypoplasia of the uterus (HP:0000013)1.75309028
94Absent/shortened dynein arms (HP:0200106)1.75111721
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.75111721
96Episodic fever (HP:0001954)1.74559518
97Abnormal rod and cone electroretinograms (HP:0008323)1.74299390
98Severe visual impairment (HP:0001141)1.73361197
99Thyroid-stimulating hormone excess (HP:0002925)1.73131608
100Delayed CNS myelination (HP:0002188)1.72952166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.25472974
2MST42.87913293
3CDK192.46006542
4PTK2B2.32077546
5MAP2K32.28503917
6NME22.25835932
7TLK12.25012680
8ARAF2.07092394
9CSF1R2.05895697
10KIT2.05667493
11TEC1.95616574
12KDR1.95104225
13RIPK41.91301555
14FES1.87332658
15BCKDK1.86149865
16TESK21.82901486
17MYLK1.79924554
18SYK1.78782495
19MATK1.68090653
20BLK1.68009734
21PIM21.67892444
22BMPR21.64557038
23GRK71.62529168
24JAK31.61243662
25NUAK11.55791153
26MAP3K31.55085913
27BTK1.51413392
28ZAK1.50965532
29MAPKAPK31.50149195
30MAP4K11.44595280
31TBK11.42064848
32MAP4K21.38249568
33IKBKB1.30489952
34IRAK31.30424275
35ADRBK21.30418965
36TAOK31.28823100
37ABL21.28535215
38PHKG21.25357279
39PHKG11.25357279
40MAPK131.23850125
41EPHB21.23104765
42GRK11.18487228
43GRK51.17626757
44FGR1.17510941
45FLT31.16207028
46CDK81.13264621
47FRK1.12945600
48LYN1.11433082
49DAPK11.05543975
50ZAP700.99501653
51TAOK20.96675900
52BMPR1B0.94224216
53MAP3K110.93452793
54ILK0.93304241
55HIPK20.92670138
56MAPKAPK50.89511855
57ITK0.89067315
58EIF2AK30.87616683
59PIK3CG0.87029876
60BMX0.86889235
61HCK0.84528625
62CSNK1G30.83191969
63OXSR10.82794993
64TNK20.80267635
65STK160.80233817
66MOS0.79892678
67DAPK30.78556011
68PAK10.78080532
69LIMK10.77561618
70VRK10.75883685
71LMTK20.75424637
72GRK60.73951966
73PLK20.72678667
74MAP3K50.69978289
75TESK10.69459341
76ADRBK10.68997075
77ACVR1B0.67183315
78DAPK20.65715954
79CSK0.61239245
80EIF2AK10.58735004
81CSNK1G20.56690724
82CCNB10.56230157
83MAP3K120.56214992
84MUSK0.55744315
85MARK30.55347741
86IKBKE0.53623133
87TIE10.53506258
88LCK0.52405981
89RPS6KA50.50481990
90CSNK1G10.48947771
91PRKCI0.47448539
92IRAK40.47307635
93STK240.43086388
94ABL10.42296027
95CSNK1A1L0.41544170
96FER0.40104984
97RAF10.38838993
98AURKA0.37577113
99TXK0.36955964
100TAOK10.36125460

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.37562273
2Allograft rejection_Homo sapiens_hsa053303.53800010
3Autoimmune thyroid disease_Homo sapiens_hsa053203.20099175
4Graft-versus-host disease_Homo sapiens_hsa053323.10835981
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.07847793
6Proteasome_Homo sapiens_hsa030502.86867054
7Type I diabetes mellitus_Homo sapiens_hsa049402.64791273
8Oxidative phosphorylation_Homo sapiens_hsa001902.50215120
9Caffeine metabolism_Homo sapiens_hsa002322.47089968
10Sulfur metabolism_Homo sapiens_hsa009202.42377461
11Staphylococcus aureus infection_Homo sapiens_hsa051502.38348111
12Rheumatoid arthritis_Homo sapiens_hsa053232.36915252
13Antigen processing and presentation_Homo sapiens_hsa046122.03865631
14Parkinsons disease_Homo sapiens_hsa050122.02382992
15Leishmaniasis_Homo sapiens_hsa051401.92817028
16Viral myocarditis_Homo sapiens_hsa054161.75692480
17Collecting duct acid secretion_Homo sapiens_hsa049661.72822387
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69780590
19Arachidonic acid metabolism_Homo sapiens_hsa005901.65688095
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64042957
21Hematopoietic cell lineage_Homo sapiens_hsa046401.62196639
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60335668
23Glutathione metabolism_Homo sapiens_hsa004801.32567196
24Other glycan degradation_Homo sapiens_hsa005111.27498620
25Platelet activation_Homo sapiens_hsa046111.25754221
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20768464
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20562004
28Ribosome_Homo sapiens_hsa030101.20136197
29Huntingtons disease_Homo sapiens_hsa050161.19281720
30Alzheimers disease_Homo sapiens_hsa050101.18950608
31Systemic lupus erythematosus_Homo sapiens_hsa053221.18861252
32Lysosome_Homo sapiens_hsa041421.15245820
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.13030356
34Phagosome_Homo sapiens_hsa041451.12945044
35Tuberculosis_Homo sapiens_hsa051521.12427379
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10294590
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07973326
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.07953511
39Base excision repair_Homo sapiens_hsa034101.03956799
40Legionellosis_Homo sapiens_hsa051341.03472557
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.01099750
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99480942
43Linoleic acid metabolism_Homo sapiens_hsa005910.98363441
44Pentose phosphate pathway_Homo sapiens_hsa000300.96803716
45Regulation of autophagy_Homo sapiens_hsa041400.93357030
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92721269
47Chemical carcinogenesis_Homo sapiens_hsa052040.91897529
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86235140
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.85994774
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85482850
51Primary immunodeficiency_Homo sapiens_hsa053400.84483198
52Fatty acid elongation_Homo sapiens_hsa000620.83498876
53RNA polymerase_Homo sapiens_hsa030200.79878168
54Pyrimidine metabolism_Homo sapiens_hsa002400.77868674
55Mismatch repair_Homo sapiens_hsa034300.76703976
56One carbon pool by folate_Homo sapiens_hsa006700.71976216
57Nucleotide excision repair_Homo sapiens_hsa034200.70714942
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70603785
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69882271
60Shigellosis_Homo sapiens_hsa051310.66586188
61Herpes simplex infection_Homo sapiens_hsa051680.66368785
62Purine metabolism_Homo sapiens_hsa002300.66237450
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64570081
64Pertussis_Homo sapiens_hsa051330.63355320
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61176785
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59598682
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59174960
68Ether lipid metabolism_Homo sapiens_hsa005650.57321913
69Nitrogen metabolism_Homo sapiens_hsa009100.56430159
70Peroxisome_Homo sapiens_hsa041460.56300085
71Malaria_Homo sapiens_hsa051440.55411700
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54497446
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54296766
74Protein export_Homo sapiens_hsa030600.52834637
75DNA replication_Homo sapiens_hsa030300.52244763
76Toxoplasmosis_Homo sapiens_hsa051450.51855707
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50322015
78Galactose metabolism_Homo sapiens_hsa000520.50292704
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49722486
80Tryptophan metabolism_Homo sapiens_hsa003800.48366821
81Influenza A_Homo sapiens_hsa051640.48080602
82Phototransduction_Homo sapiens_hsa047440.46274257
83Serotonergic synapse_Homo sapiens_hsa047260.45758555
84Salmonella infection_Homo sapiens_hsa051320.45587103
85Osteoclast differentiation_Homo sapiens_hsa043800.45552799
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.44367355
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43731684
88Cardiac muscle contraction_Homo sapiens_hsa042600.42849527
89Sulfur relay system_Homo sapiens_hsa041220.41843912
90Retinol metabolism_Homo sapiens_hsa008300.39258946
91Metabolic pathways_Homo sapiens_hsa011000.38478322
92RNA degradation_Homo sapiens_hsa030180.37544194
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35449151
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35320616
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33933386
96Vibrio cholerae infection_Homo sapiens_hsa051100.33750376
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32013980
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.31140279
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28385790
100Olfactory transduction_Homo sapiens_hsa047400.23312567

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