Rank | Gene Set | Z-score |
---|---|---|
1 | protein neddylation (GO:0045116) | 6.43463474 |
2 | neutrophil activation involved in immune response (GO:0002283) | 5.47945556 |
3 | immunoglobulin mediated immune response (GO:0016064) | 4.54125816 |
4 | adenosine metabolic process (GO:0046085) | 3.93111891 |
5 | B cell mediated immunity (GO:0019724) | 3.92871947 |
6 | platelet dense granule organization (GO:0060155) | 3.89842065 |
7 | purine nucleotide salvage (GO:0032261) | 3.89026624 |
8 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.88305639 |
9 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.76201306 |
10 | DNA deamination (GO:0045006) | 3.63357473 |
11 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.59986162 |
12 | lipoxygenase pathway (GO:0019372) | 3.44764707 |
13 | response to xenobiotic stimulus (GO:0009410) | 3.36915502 |
14 | xenobiotic catabolic process (GO:0042178) | 3.36647576 |
15 | skeletal muscle tissue regeneration (GO:0043403) | 3.36421535 |
16 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.15215951 |
17 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.06646393 |
18 | heart process (GO:0003015) | 3.05927444 |
19 | heart contraction (GO:0060047) | 3.05927444 |
20 | positive regulation of mast cell activation (GO:0033005) | 3.04097493 |
21 | purine-containing compound salvage (GO:0043101) | 3.00793038 |
22 | regulation of mast cell activation (GO:0033003) | 2.98522821 |
23 | response to interferon-beta (GO:0035456) | 2.96588174 |
24 | neutrophil activation (GO:0042119) | 2.91399501 |
25 | fusion of sperm to egg plasma membrane (GO:0007342) | 2.90492548 |
26 | regulation of platelet activation (GO:0010543) | 2.89268423 |
27 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.87657685 |
28 | cellular biogenic amine catabolic process (GO:0042402) | 2.86932547 |
29 | amine catabolic process (GO:0009310) | 2.86932547 |
30 | regulation of B cell apoptotic process (GO:0002902) | 2.86234839 |
31 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.86193203 |
32 | response to gravity (GO:0009629) | 2.85531488 |
33 | autophagic vacuole fusion (GO:0000046) | 2.83185317 |
34 | negative regulation of heart rate (GO:0010459) | 2.79263315 |
35 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.78735188 |
36 | deoxyribonucleotide catabolic process (GO:0009264) | 2.77475677 |
37 | GMP metabolic process (GO:0046037) | 2.75569065 |
38 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.74316884 |
39 | positive regulation of endothelial cell differentiation (GO:0045603) | 2.73815740 |
40 | mitochondrial calcium ion transport (GO:0006851) | 2.72693145 |
41 | positive regulation of mast cell degranulation (GO:0043306) | 2.72635669 |
42 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.72635669 |
43 | leukocyte migration involved in inflammatory response (GO:0002523) | 2.72243601 |
44 | granulocyte activation (GO:0036230) | 2.71169984 |
45 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.71104079 |
46 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.70370856 |
47 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.69575411 |
48 | ATP synthesis coupled proton transport (GO:0015986) | 2.69575411 |
49 | protein complex biogenesis (GO:0070271) | 2.69556232 |
50 | thrombin receptor signaling pathway (GO:0070493) | 2.67213549 |
51 | protein maturation by protein folding (GO:0022417) | 2.66631056 |
52 | deoxyribose phosphate catabolic process (GO:0046386) | 2.66468897 |
53 | nucleotide salvage (GO:0043173) | 2.66141248 |
54 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.65656372 |
55 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.65533572 |
56 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.64831361 |
57 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.64831361 |
58 | NADH dehydrogenase complex assembly (GO:0010257) | 2.64831361 |
59 | response to hydroperoxide (GO:0033194) | 2.64472414 |
60 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.61036729 |
61 | regulation of skeletal muscle contraction (GO:0014819) | 2.60861169 |
62 | intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631) | 2.60757716 |
63 | regulation of thymocyte apoptotic process (GO:0070243) | 2.57415199 |
64 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.55633387 |
65 | plasma membrane fusion (GO:0045026) | 2.55135397 |
66 | positive regulation of antigen processing and presentation (GO:0002579) | 2.53932431 |
67 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.53375849 |
68 | sulfur amino acid catabolic process (GO:0000098) | 2.52755907 |
69 | response to peptidoglycan (GO:0032494) | 2.52252608 |
70 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.51705660 |
71 | leukocyte degranulation (GO:0043299) | 2.50042590 |
72 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.49759000 |
73 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.49669975 |
74 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.49011277 |
75 | positive regulation of systemic arterial blood pressure (GO:0003084) | 2.47423033 |
76 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 2.45520988 |
77 | positive regulation of protein homodimerization activity (GO:0090073) | 2.44080016 |
78 | cullin deneddylation (GO:0010388) | 2.42960885 |
79 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.42108051 |
80 | myeloid cell activation involved in immune response (GO:0002275) | 2.41312972 |
81 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 2.40764130 |
82 | sequestering of actin monomers (GO:0042989) | 2.39290531 |
83 | mitochondrial calcium ion homeostasis (GO:0051560) | 2.38700877 |
84 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.37385483 |
85 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.37289503 |
86 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.37289503 |
87 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.36711272 |
88 | positive regulation of prostaglandin secretion (GO:0032308) | 2.36513186 |
89 | regulation of mast cell degranulation (GO:0043304) | 2.36471771 |
90 | protein deneddylation (GO:0000338) | 2.36053052 |
91 | negative regulation of mast cell activation (GO:0033004) | 2.35549051 |
92 | phagosome maturation (GO:0090382) | 2.35213590 |
93 | respiratory chain complex IV assembly (GO:0008535) | 2.33752704 |
94 | cytochrome complex assembly (GO:0017004) | 2.33658128 |
95 | angiogenesis involved in wound healing (GO:0060055) | 2.33444072 |
96 | mature B cell differentiation involved in immune response (GO:0002313) | 2.33266459 |
97 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.33202433 |
98 | L-phenylalanine catabolic process (GO:0006559) | 2.33202433 |
99 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.32351126 |
100 | regulation of germinal center formation (GO:0002634) | 2.31216925 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.65328275 |
2 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.69197122 |
3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.54623151 |
4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.44491122 |
5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.12233814 |
6 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 3.05312213 |
7 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.93092928 |
8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.87942327 |
9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.71592608 |
10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.71526990 |
11 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.69301969 |
12 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.67006016 |
13 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.47633048 |
14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.42020562 |
15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.34418523 |
16 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.31636044 |
17 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.30212797 |
18 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.23837428 |
19 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.23591533 |
20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16211110 |
21 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.14277446 |
22 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.07006263 |
23 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.99134740 |
24 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.88695082 |
25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.87730553 |
26 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.87673508 |
27 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.87063532 |
28 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.84068962 |
29 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.83095424 |
30 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.76860389 |
31 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.71979325 |
32 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.69322018 |
33 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.65384276 |
34 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.63651136 |
35 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.62060761 |
36 | SPI1_23127762_ChIP-Seq_K562_Human | 1.59757093 |
37 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.59352436 |
38 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.58225834 |
39 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.56658719 |
40 | VDR_22108803_ChIP-Seq_LS180_Human | 1.49926563 |
41 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.49242428 |
42 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.43614577 |
43 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35448083 |
44 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.35207357 |
45 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.33508106 |
46 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.32967872 |
47 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.31423303 |
48 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.31415782 |
49 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.30894012 |
50 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.29469420 |
51 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.29455258 |
52 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.28000899 |
53 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.26767907 |
54 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.26117295 |
55 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.26043780 |
56 | GATA3_26560356_Chip-Seq_TH2_Human | 1.25216760 |
57 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.23776507 |
58 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.23631682 |
59 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.23487249 |
60 | MYB_26560356_Chip-Seq_TH2_Human | 1.22866214 |
61 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.21209609 |
62 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.19671987 |
63 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.17796126 |
64 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.15669604 |
65 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.11321546 |
66 | AR_20517297_ChIP-Seq_VCAP_Human | 1.10536245 |
67 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.09549240 |
68 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.08157625 |
69 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.07255433 |
70 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.06541520 |
71 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.06348025 |
72 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.06031216 |
73 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.02478867 |
74 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01868738 |
75 | P300_27268052_Chip-Seq_Bcells_Human | 1.01469494 |
76 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.00847573 |
77 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.00678075 |
78 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.00676414 |
79 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.00506404 |
80 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.99988914 |
81 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.99985742 |
82 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.99947448 |
83 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.99333249 |
84 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.99054426 |
85 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.98695339 |
86 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.98489997 |
87 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.96996490 |
88 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.96664040 |
89 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.95994107 |
90 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.95766588 |
91 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.94127984 |
92 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92320831 |
93 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91485439 |
94 | MYB_26560356_Chip-Seq_TH1_Human | 0.90788668 |
95 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.90275277 |
96 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.88929435 |
97 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.87908418 |
98 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.87862350 |
99 | UTX_26944678_Chip-Seq_JUKART_Human | 0.87813912 |
100 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.86874456 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005464_abnormal_platelet_physiology | 4.66713104 |
2 | MP0003724_increased_susceptibility_to | 3.69598789 |
3 | MP0003806_abnormal_nucleotide_metabolis | 3.69594719 |
4 | MP0001835_abnormal_antigen_presentation | 3.55666971 |
5 | MP0002138_abnormal_hepatobiliary_system | 3.17731004 |
6 | MP0002148_abnormal_hypersensitivity_rea | 3.02922912 |
7 | MP0005058_abnormal_lysosome_morphology | 2.59373529 |
8 | MP0003303_peritoneal_inflammation | 2.46016634 |
9 | MP0005000_abnormal_immune_tolerance | 2.15585434 |
10 | MP0009785_altered_susceptibility_to | 2.08731127 |
11 | MP0005084_abnormal_gallbladder_morpholo | 2.04577210 |
12 | MP0005671_abnormal_response_to | 2.01618366 |
13 | MP0003186_abnormal_redox_activity | 2.00270663 |
14 | MP0002419_abnormal_innate_immunity | 1.98929755 |
15 | MP0003075_altered_response_to | 1.98529062 |
16 | MP0000343_altered_response_to | 1.98126309 |
17 | MP0008004_abnormal_stomach_pH | 1.94758861 |
18 | MP0002139_abnormal_hepatobiliary_system | 1.91614078 |
19 | MP0003436_decreased_susceptibility_to | 1.91176982 |
20 | MP0008875_abnormal_xenobiotic_pharmacok | 1.91030817 |
21 | MP0006292_abnormal_olfactory_placode | 1.86844144 |
22 | MP0009764_decreased_sensitivity_to | 1.83730446 |
23 | MP0002452_abnormal_antigen_presenting | 1.82665741 |
24 | MP0002723_abnormal_immune_serum | 1.81099070 |
25 | MP0001800_abnormal_humoral_immune | 1.78659098 |
26 | MP0005257_abnormal_intraocular_pressure | 1.74584268 |
27 | MP0006036_abnormal_mitochondrial_physio | 1.72093046 |
28 | MP0005410_abnormal_fertilization | 1.65454181 |
29 | MP0005025_abnormal_response_to | 1.65128235 |
30 | MP0000685_abnormal_immune_system | 1.58289111 |
31 | MP0001764_abnormal_homeostasis | 1.57836075 |
32 | MP0002420_abnormal_adaptive_immunity | 1.57199291 |
33 | MP0001819_abnormal_immune_cell | 1.55310498 |
34 | MP0005360_urolithiasis | 1.54114299 |
35 | MP0001533_abnormal_skeleton_physiology | 1.51319738 |
36 | MP0001790_abnormal_immune_system | 1.48793416 |
37 | MP0005387_immune_system_phenotype | 1.48793416 |
38 | MP0005397_hematopoietic_system_phenotyp | 1.47391014 |
39 | MP0001545_abnormal_hematopoietic_system | 1.47391014 |
40 | MP0010155_abnormal_intestine_physiology | 1.46247873 |
41 | MP0005646_abnormal_pituitary_gland | 1.43732928 |
42 | MP0001845_abnormal_inflammatory_respons | 1.42616358 |
43 | MP0005165_increased_susceptibility_to | 1.41865505 |
44 | MP0006082_CNS_inflammation | 1.31036270 |
45 | MP0000465_gastrointestinal_hemorrhage | 1.30843978 |
46 | MP0002736_abnormal_nociception_after | 1.29974336 |
47 | MP0008469_abnormal_protein_level | 1.29319194 |
48 | MP0002398_abnormal_bone_marrow | 1.26298167 |
49 | MP0005083_abnormal_biliary_tract | 1.25635364 |
50 | MP0003638_abnormal_response/metabolism_ | 1.25157528 |
51 | MP0008789_abnormal_olfactory_epithelium | 1.24690560 |
52 | MP0003828_pulmonary_edema | 1.22570160 |
53 | MP0000858_altered_metastatic_potential | 1.21793239 |
54 | MP0000689_abnormal_spleen_morphology | 1.18607990 |
55 | MP0000716_abnormal_immune_system | 1.17161264 |
56 | MP0005166_decreased_susceptibility_to | 1.10531109 |
57 | MP0002837_dystrophic_cardiac_calcinosis | 1.08793275 |
58 | MP0002638_abnormal_pupillary_reflex | 1.08691322 |
59 | MP0002429_abnormal_blood_cell | 1.08459005 |
60 | MP0001663_abnormal_digestive_system | 1.07761757 |
61 | MP0006054_spinal_hemorrhage | 1.07593557 |
62 | MP0008260_abnormal_autophagy | 1.07217162 |
63 | MP0000230_abnormal_systemic_arterial | 1.04932917 |
64 | MP0005167_abnormal_blood-brain_barrier | 1.03916488 |
65 | MP0009333_abnormal_splenocyte_physiolog | 1.03293940 |
66 | MP0001542_abnormal_bone_strength | 1.01452872 |
67 | MP0002102_abnormal_ear_morphology | 1.00911200 |
68 | MP0008872_abnormal_physiological_respon | 1.00135713 |
69 | MP0009763_increased_sensitivity_to | 0.98633410 |
70 | MP0003183_abnormal_peptide_metabolism | 0.98495187 |
71 | MP0009697_abnormal_copulation | 0.97646179 |
72 | MP0002132_abnormal_respiratory_system | 0.96541344 |
73 | MP0002722_abnormal_immune_system | 0.95920073 |
74 | MP0003011_delayed_dark_adaptation | 0.95913321 |
75 | MP0006276_abnormal_autonomic_nervous | 0.94966789 |
76 | MP0009278_abnormal_bone_marrow | 0.93461944 |
77 | MP0000372_irregular_coat_pigmentation | 0.92707413 |
78 | MP0005319_abnormal_enzyme/_coenzyme | 0.92318150 |
79 | MP0005085_abnormal_gallbladder_physiolo | 0.90915024 |
80 | MP0006035_abnormal_mitochondrial_morpho | 0.88925841 |
81 | MP0005332_abnormal_amino_acid | 0.88437334 |
82 | MP0003866_abnormal_defecation | 0.87751454 |
83 | MP0005365_abnormal_bile_salt | 0.86856291 |
84 | MP0001905_abnormal_dopamine_level | 0.84699048 |
85 | MP0002405_respiratory_system_inflammati | 0.84627603 |
86 | MP0004147_increased_porphyrin_level | 0.84026606 |
87 | MP0001968_abnormal_touch/_nociception | 0.83098876 |
88 | MP0000358_abnormal_cell_content/ | 0.82214115 |
89 | MP0004808_abnormal_hematopoietic_stem | 0.81695716 |
90 | MP0009643_abnormal_urine_homeostasis | 0.81500529 |
91 | MP0002332_abnormal_exercise_endurance | 0.79776281 |
92 | MP0004510_myositis | 0.79231952 |
93 | MP0000490_abnormal_crypts_of | 0.79157921 |
94 | MP0000249_abnormal_blood_vessel | 0.78876883 |
95 | MP0001756_abnormal_urination | 0.77481772 |
96 | MP0003252_abnormal_bile_duct | 0.76273802 |
97 | MP0002733_abnormal_thermal_nociception | 0.75876568 |
98 | MP0005535_abnormal_body_temperature | 0.75306689 |
99 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.74270953 |
100 | MP0009053_abnormal_anal_canal | 0.72908809 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Petechiae (HP:0000967) | 4.99935627 |
2 | Dyschromatopsia (HP:0007641) | 4.60498637 |
3 | Prolonged bleeding time (HP:0003010) | 4.24428734 |
4 | Generalized aminoaciduria (HP:0002909) | 4.06867653 |
5 | Purpura (HP:0000979) | 3.88387276 |
6 | Epistaxis (HP:0000421) | 3.61483894 |
7 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.30224393 |
8 | 3-Methylglutaconic aciduria (HP:0003535) | 3.29360528 |
9 | Hyperlipoproteinemia (HP:0010980) | 3.23839740 |
10 | Menorrhagia (HP:0000132) | 3.14139516 |
11 | Acute necrotizing encephalopathy (HP:0006965) | 3.11894632 |
12 | Decreased central vision (HP:0007663) | 3.10762068 |
13 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.07947823 |
14 | Abnormality of alanine metabolism (HP:0010916) | 3.07947823 |
15 | Hyperalaninemia (HP:0003348) | 3.07947823 |
16 | Abnormality of the prostate (HP:0008775) | 3.03166977 |
17 | Abnormality of macrophages (HP:0004311) | 3.01618758 |
18 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.00543938 |
19 | Hypoplasia of the fovea (HP:0007750) | 3.00543938 |
20 | Type 2 muscle fiber atrophy (HP:0003554) | 2.96780293 |
21 | Mitochondrial inheritance (HP:0001427) | 2.91177624 |
22 | Abnormality of glycolipid metabolism (HP:0010969) | 2.85090546 |
23 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.85090546 |
24 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.85090546 |
25 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.81527102 |
26 | Recurrent bacterial skin infections (HP:0005406) | 2.79485129 |
27 | Recurrent abscess formation (HP:0002722) | 2.77895500 |
28 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.77007588 |
29 | Hepatic necrosis (HP:0002605) | 2.74308234 |
30 | Muscle fiber atrophy (HP:0100295) | 2.73779709 |
31 | Vacuolated lymphocytes (HP:0001922) | 2.72225719 |
32 | Chronic obstructive pulmonary disease (HP:0006510) | 2.71767393 |
33 | Obstructive lung disease (HP:0006536) | 2.71767393 |
34 | Nausea (HP:0002018) | 2.70515628 |
35 | Hepatosplenomegaly (HP:0001433) | 2.69567464 |
36 | Stomatitis (HP:0010280) | 2.69567221 |
37 | Abnormality of lateral ventricle (HP:0030047) | 2.67398931 |
38 | Renal Fanconi syndrome (HP:0001994) | 2.65933841 |
39 | Abnormality of the fovea (HP:0000493) | 2.63912196 |
40 | Progressive macrocephaly (HP:0004481) | 2.61434337 |
41 | Acute encephalopathy (HP:0006846) | 2.59081308 |
42 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.58019723 |
43 | Increased CSF lactate (HP:0002490) | 2.51570649 |
44 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.49881951 |
45 | Conjunctival telangiectasia (HP:0000524) | 2.47492691 |
46 | Hepatocellular necrosis (HP:0001404) | 2.44642516 |
47 | Paralysis (HP:0003470) | 2.39086400 |
48 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.37160155 |
49 | Increased mean platelet volume (HP:0011877) | 2.32029645 |
50 | Exertional dyspnea (HP:0002875) | 2.29761707 |
51 | Abnormal platelet volume (HP:0011876) | 2.29374236 |
52 | Impaired platelet aggregation (HP:0003540) | 2.28172432 |
53 | Abnormal platelet function (HP:0011869) | 2.28172432 |
54 | Cerebral edema (HP:0002181) | 2.24100893 |
55 | Constricted visual fields (HP:0001133) | 2.18549575 |
56 | Gingival bleeding (HP:0000225) | 2.16187535 |
57 | Myositis (HP:0100614) | 2.13260065 |
58 | Spontaneous hematomas (HP:0007420) | 2.13230161 |
59 | Abnormal drinking behavior (HP:0030082) | 2.10811706 |
60 | Polydipsia (HP:0001959) | 2.10811706 |
61 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.08405922 |
62 | Dysostosis multiplex (HP:0000943) | 2.07690965 |
63 | Pulmonary embolism (HP:0002204) | 2.07486700 |
64 | Lactic acidosis (HP:0003128) | 2.05097673 |
65 | Abnormality of magnesium homeostasis (HP:0004921) | 2.04991517 |
66 | Attenuation of retinal blood vessels (HP:0007843) | 2.04229326 |
67 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.03574212 |
68 | Abnormal pupillary function (HP:0007686) | 2.03453634 |
69 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.02654636 |
70 | Increased IgM level (HP:0003496) | 2.02207047 |
71 | Abolished electroretinogram (ERG) (HP:0000550) | 2.01349393 |
72 | Increased serum ferritin (HP:0003281) | 1.97549467 |
73 | Ketoacidosis (HP:0001993) | 1.96628963 |
74 | Progressive neurologic deterioration (HP:0002344) | 1.96191899 |
75 | Increased serum lactate (HP:0002151) | 1.96133536 |
76 | Polyuria (HP:0000103) | 1.93841129 |
77 | Encephalitis (HP:0002383) | 1.93156133 |
78 | Anorexia (HP:0002039) | 1.92965484 |
79 | Abnormality of iron homeostasis (HP:0011031) | 1.91572817 |
80 | Prostate neoplasm (HP:0100787) | 1.89683199 |
81 | Urticaria (HP:0001025) | 1.89221376 |
82 | Glycosuria (HP:0003076) | 1.88440079 |
83 | Abnormality of urine glucose concentration (HP:0011016) | 1.88440079 |
84 | Amyloidosis (HP:0011034) | 1.87863847 |
85 | Meningitis (HP:0001287) | 1.84639496 |
86 | Pulmonary fibrosis (HP:0002206) | 1.82762689 |
87 | Tongue fasciculations (HP:0001308) | 1.80805966 |
88 | Hypomagnesemia (HP:0002917) | 1.79176168 |
89 | Autoimmune thrombocytopenia (HP:0001973) | 1.77822452 |
90 | Palpebral edema (HP:0100540) | 1.77787943 |
91 | Type I transferrin isoform profile (HP:0003642) | 1.77648973 |
92 | Basal ganglia calcification (HP:0002135) | 1.77284306 |
93 | Hypoplasia of the uterus (HP:0000013) | 1.75309028 |
94 | Absent/shortened dynein arms (HP:0200106) | 1.75111721 |
95 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.75111721 |
96 | Episodic fever (HP:0001954) | 1.74559518 |
97 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.74299390 |
98 | Severe visual impairment (HP:0001141) | 1.73361197 |
99 | Thyroid-stimulating hormone excess (HP:0002925) | 1.73131608 |
100 | Delayed CNS myelination (HP:0002188) | 1.72952166 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 3.25472974 |
2 | MST4 | 2.87913293 |
3 | CDK19 | 2.46006542 |
4 | PTK2B | 2.32077546 |
5 | MAP2K3 | 2.28503917 |
6 | NME2 | 2.25835932 |
7 | TLK1 | 2.25012680 |
8 | ARAF | 2.07092394 |
9 | CSF1R | 2.05895697 |
10 | KIT | 2.05667493 |
11 | TEC | 1.95616574 |
12 | KDR | 1.95104225 |
13 | RIPK4 | 1.91301555 |
14 | FES | 1.87332658 |
15 | BCKDK | 1.86149865 |
16 | TESK2 | 1.82901486 |
17 | MYLK | 1.79924554 |
18 | SYK | 1.78782495 |
19 | MATK | 1.68090653 |
20 | BLK | 1.68009734 |
21 | PIM2 | 1.67892444 |
22 | BMPR2 | 1.64557038 |
23 | GRK7 | 1.62529168 |
24 | JAK3 | 1.61243662 |
25 | NUAK1 | 1.55791153 |
26 | MAP3K3 | 1.55085913 |
27 | BTK | 1.51413392 |
28 | ZAK | 1.50965532 |
29 | MAPKAPK3 | 1.50149195 |
30 | MAP4K1 | 1.44595280 |
31 | TBK1 | 1.42064848 |
32 | MAP4K2 | 1.38249568 |
33 | IKBKB | 1.30489952 |
34 | IRAK3 | 1.30424275 |
35 | ADRBK2 | 1.30418965 |
36 | TAOK3 | 1.28823100 |
37 | ABL2 | 1.28535215 |
38 | PHKG2 | 1.25357279 |
39 | PHKG1 | 1.25357279 |
40 | MAPK13 | 1.23850125 |
41 | EPHB2 | 1.23104765 |
42 | GRK1 | 1.18487228 |
43 | GRK5 | 1.17626757 |
44 | FGR | 1.17510941 |
45 | FLT3 | 1.16207028 |
46 | CDK8 | 1.13264621 |
47 | FRK | 1.12945600 |
48 | LYN | 1.11433082 |
49 | DAPK1 | 1.05543975 |
50 | ZAP70 | 0.99501653 |
51 | TAOK2 | 0.96675900 |
52 | BMPR1B | 0.94224216 |
53 | MAP3K11 | 0.93452793 |
54 | ILK | 0.93304241 |
55 | HIPK2 | 0.92670138 |
56 | MAPKAPK5 | 0.89511855 |
57 | ITK | 0.89067315 |
58 | EIF2AK3 | 0.87616683 |
59 | PIK3CG | 0.87029876 |
60 | BMX | 0.86889235 |
61 | HCK | 0.84528625 |
62 | CSNK1G3 | 0.83191969 |
63 | OXSR1 | 0.82794993 |
64 | TNK2 | 0.80267635 |
65 | STK16 | 0.80233817 |
66 | MOS | 0.79892678 |
67 | DAPK3 | 0.78556011 |
68 | PAK1 | 0.78080532 |
69 | LIMK1 | 0.77561618 |
70 | VRK1 | 0.75883685 |
71 | LMTK2 | 0.75424637 |
72 | GRK6 | 0.73951966 |
73 | PLK2 | 0.72678667 |
74 | MAP3K5 | 0.69978289 |
75 | TESK1 | 0.69459341 |
76 | ADRBK1 | 0.68997075 |
77 | ACVR1B | 0.67183315 |
78 | DAPK2 | 0.65715954 |
79 | CSK | 0.61239245 |
80 | EIF2AK1 | 0.58735004 |
81 | CSNK1G2 | 0.56690724 |
82 | CCNB1 | 0.56230157 |
83 | MAP3K12 | 0.56214992 |
84 | MUSK | 0.55744315 |
85 | MARK3 | 0.55347741 |
86 | IKBKE | 0.53623133 |
87 | TIE1 | 0.53506258 |
88 | LCK | 0.52405981 |
89 | RPS6KA5 | 0.50481990 |
90 | CSNK1G1 | 0.48947771 |
91 | PRKCI | 0.47448539 |
92 | IRAK4 | 0.47307635 |
93 | STK24 | 0.43086388 |
94 | ABL1 | 0.42296027 |
95 | CSNK1A1L | 0.41544170 |
96 | FER | 0.40104984 |
97 | RAF1 | 0.38838993 |
98 | AURKA | 0.37577113 |
99 | TXK | 0.36955964 |
100 | TAOK1 | 0.36125460 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Asthma_Homo sapiens_hsa05310 | 4.37562273 |
2 | Allograft rejection_Homo sapiens_hsa05330 | 3.53800010 |
3 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.20099175 |
4 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.10835981 |
5 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.07847793 |
6 | Proteasome_Homo sapiens_hsa03050 | 2.86867054 |
7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.64791273 |
8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.50215120 |
9 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.47089968 |
10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.42377461 |
11 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.38348111 |
12 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.36915252 |
13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.03865631 |
14 | Parkinsons disease_Homo sapiens_hsa05012 | 2.02382992 |
15 | Leishmaniasis_Homo sapiens_hsa05140 | 1.92817028 |
16 | Viral myocarditis_Homo sapiens_hsa05416 | 1.75692480 |
17 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.72822387 |
18 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.69780590 |
19 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.65688095 |
20 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.64042957 |
21 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.62196639 |
22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.60335668 |
23 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.32567196 |
24 | Other glycan degradation_Homo sapiens_hsa00511 | 1.27498620 |
25 | Platelet activation_Homo sapiens_hsa04611 | 1.25754221 |
26 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.20768464 |
27 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.20562004 |
28 | Ribosome_Homo sapiens_hsa03010 | 1.20136197 |
29 | Huntingtons disease_Homo sapiens_hsa05016 | 1.19281720 |
30 | Alzheimers disease_Homo sapiens_hsa05010 | 1.18950608 |
31 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.18861252 |
32 | Lysosome_Homo sapiens_hsa04142 | 1.15245820 |
33 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.13030356 |
34 | Phagosome_Homo sapiens_hsa04145 | 1.12945044 |
35 | Tuberculosis_Homo sapiens_hsa05152 | 1.12427379 |
36 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.10294590 |
37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.07973326 |
38 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.07953511 |
39 | Base excision repair_Homo sapiens_hsa03410 | 1.03956799 |
40 | Legionellosis_Homo sapiens_hsa05134 | 1.03472557 |
41 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.01099750 |
42 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.99480942 |
43 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.98363441 |
44 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.96803716 |
45 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.93357030 |
46 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.92721269 |
47 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.91897529 |
48 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.86235140 |
49 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.85994774 |
50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.85482850 |
51 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.84483198 |
52 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.83498876 |
53 | RNA polymerase_Homo sapiens_hsa03020 | 0.79878168 |
54 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.77868674 |
55 | Mismatch repair_Homo sapiens_hsa03430 | 0.76703976 |
56 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.71976216 |
57 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.70714942 |
58 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.70603785 |
59 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.69882271 |
60 | Shigellosis_Homo sapiens_hsa05131 | 0.66586188 |
61 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.66368785 |
62 | Purine metabolism_Homo sapiens_hsa00230 | 0.66237450 |
63 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.64570081 |
64 | Pertussis_Homo sapiens_hsa05133 | 0.63355320 |
65 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.61176785 |
66 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.59598682 |
67 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.59174960 |
68 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.57321913 |
69 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56430159 |
70 | Peroxisome_Homo sapiens_hsa04146 | 0.56300085 |
71 | Malaria_Homo sapiens_hsa05144 | 0.55411700 |
72 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.54497446 |
73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54296766 |
74 | Protein export_Homo sapiens_hsa03060 | 0.52834637 |
75 | DNA replication_Homo sapiens_hsa03030 | 0.52244763 |
76 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.51855707 |
77 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.50322015 |
78 | Galactose metabolism_Homo sapiens_hsa00052 | 0.50292704 |
79 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.49722486 |
80 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.48366821 |
81 | Influenza A_Homo sapiens_hsa05164 | 0.48080602 |
82 | Phototransduction_Homo sapiens_hsa04744 | 0.46274257 |
83 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.45758555 |
84 | Salmonella infection_Homo sapiens_hsa05132 | 0.45587103 |
85 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.45552799 |
86 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.44367355 |
87 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43731684 |
88 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.42849527 |
89 | Sulfur relay system_Homo sapiens_hsa04122 | 0.41843912 |
90 | Retinol metabolism_Homo sapiens_hsa00830 | 0.39258946 |
91 | Metabolic pathways_Homo sapiens_hsa01100 | 0.38478322 |
92 | RNA degradation_Homo sapiens_hsa03018 | 0.37544194 |
93 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.35449151 |
94 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.35320616 |
95 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.33933386 |
96 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.33750376 |
97 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.32013980 |
98 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.31140279 |
99 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.28385790 |
100 | Olfactory transduction_Homo sapiens_hsa04740 | 0.23312567 |